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354 results on '"Ohashi, Takuma"'

7. Comparison of standardized prophylactic high-dose and intrathecal methotrexate for DLBCL with a high risk of CNS relapse

Author

Akimoto, Masahiro, Miyazaki, Takuya, Takahashi, Hiroyuki, Saigusa, Yusuke, Takeda, Takaaki, Hibino, Yuto, Tokunaga, Mayumi, Ohashi, Takuma, Matsumura, Ayako, Teshigawara, Haruka, Suzuki, Taisei, Teranaka, Hiroshi, Nakajima, Yuki, Matsumoto, Kenji, Hashimoto, Chizuko, Fujimaki, Katsumichi, Fujita, Hiroyuki, Sakai, Rika, Fujisawa, Shin, and Nakajima, Hideaki

Published
2024
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16. Impact of standard-dose dipeptidyl peptidase-4 inhibitors on the incidence of graft-versus-host disease after allogeneic hematopoietic cell transplantation

Author

Kimura, Shun-ichi, Shimizu, Hiroaki, Miyazaki, Takuya, Sakurai, Masatoshi, Tanoue, Susumu, Kayamori, Kensuke, Ohwada, Chikako, Yoshimura, Kazuki, Nakasone, Hideki, Ohashi, Takuma, Shono, Katsuhiro, Tachibana, Takayoshi, Hatano, Kaoru, Okada, Keigo, Kimura, Yuta, Seo, Sachiko, Doki, Noriko, Tanaka, Masatsugu, Hatta, Yoshihiro, Takahashi, Satoshi, and Kanda, Yoshinobu

Published
2023
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25. Extracellular glypican‐1 affects tumor progression and prognosis in esophageal cancer.

Author

Shibata, Rie, Konishi, Hirotaka, Arita, Tomohiro, Yamamoto, Yusuke, Matsuda, Hayato, Yamamoto, Taiga, Ohashi, Takuma, Shimizu, Hiroki, Komatsu, Shuhei, Shiozaki, Atsushi, Kubota, Takeshi, Fujiwara, Hitoshi, and Otsuji, Eigo

Subjects
CANCER cell motility, METASTASIS, CANCER invasiveness, CANCER patients, TUMOR growth, ESOPHAGEAL cancer
Abstract

Introduction: Cells are covered with a glycan surface layer that is referred to as the glycocalyx (GCX). It has been reported that the formation of the GCX is promoted on cancer cells and is associated with tumor growth and metastasis. Heparan sulfate proteoglycan glypican‐1 (GPC1) is a core protein of the GCX that is overexpressed in esophageal squamous cell carcinoma (ESCC) and is involved in the development and progression of cancer cells. The purpose of the present study is to analyze the utility of GPC1 as a new biomarker ralated to glycocalyx that reflects therapeutic effect and prognosis of ESCC. Methods: We measured the concentration of GPC1 protein in preoperative plasma from advanced esophageal cancer patients and examined its relationships with clinicopathological factors and therapeutic efficacy, and the effects of extracellular GPC1 were investigated. Results: The following clinical factors were significantly correlated with the preoperative high GPC1 concentration: male, tumor size ≥30 mm, venous invasion, pT factor ≥2, pStage ≥3, residual tumor, and distant metastatic recurrence. Both overall and recurrence‐free survival were significantly worse in the high GPC1 group. Extracellular GPC1 protein concentration reflected intracellular GPC1 expression. Furthermore, we examined the effects of extracellular recombinant human (rh)GPC1 on ESCC cells, and found that extracellular rhGPC1 affects cell motility, including migration and invasion. Conclusions: These results demonstrated the utility of extracellular GPC1 as a biomarker, which can be assayed from a less invasive blood sample‐based liquid biopsy. Extracellular GPC1 protein plays a role in both tumor cell motility and cancer progression. Thus, plasma GPC1 is a useful biomarker for esophageal cancer progression and may be a potential candidate of therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Dropped head syndrome suspected due to oxaliplatin used in adjuvant chemotherapy for gastric cancer: a case report.

Author

Marunaka, Yuta, Ohashi, Takuma, Kubota, Takeshi, Nishibeppu, Keiji, Konishi, Hirotaka, Shiozaki, Atsushi, Fujiwara, Hitoshi, and Otsuji, Eigo

Subjects
DROPPED head syndrome, ADJUVANT chemotherapy, CANCER chemotherapy, STOMACH cancer, NECK pain, OXALIPLATIN
Abstract

Background: Dropped head syndrome (DHS) is caused by dysfunction of the cervical musculature. It is classified into two groups according to the cause: one is weakness of the neck extensors and the other is hypercontraction of the cervical flexors associated with Parkinson's disease and other disorders. Although some drugs have previously been reported as suspected causes of DHS, we are unaware of any reports in which oxaliplatin was suspected. In this report, we describe a case of DHS during adjuvant chemotherapy for gastric cancer, along with a review of the relevant literature. Case presentation: A 72-year-old man was diagnosed with gastric cancer, cT3N0M0 cStage IIB, and underwent laparoscopic total gastrectomy with D2 lymphnode dissection and Roux-en-Y reconstruction. The operative time was 311 min, intraoperative blood loss was 40 g, and he was discharged without any post-operative complications. The histopathological diagnosis was pT4aN2M0 pStage IIIA, and S-1 + oxaliplatin (SOX) therapy was started as adjuvant chemotherapy. On the 4th course of SOX, he complained of neck heaviness and a blood test revealed that his creatine kinase (CK) level was elevated to 2464 IU/L. After consultation with an orthopedic surgeon and a neurologist, DHS due to localized cervical extensor myositis was suspected. Therefore, the 6th course of SOX was postponed, and 30 mg of oral steroids were initiated. His symptoms improved, and his CK level decreased within 2 weeks. After resuming S-1 monotherapy and tapering off oral steroids, no recurrence of symptoms has been observed. Conclusions: We experienced one case of DHS during adjuvant chemotherapy for gastric cancer. If DHS develops after starting oxaliplatin, involvement of the drug should be suspected, and discontinuation of chemotherapy and introduction of oral steroids should be considered. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Low blood level of tumour suppressor miR-5193 as a target of immunotherapy to PD-L1 in gastric cancer

Author

Kamiya, Hajime, primary, Komatsu, Shuhei, additional, Takashima, Yusuke, additional, Ishida, Ryo, additional, Arakawa, Hiroshi, additional, Nishibeppu, Keiji, additional, Kiuchi, Jun, additional, Imamura, Taisuke, additional, Ohashi, Takuma, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Shiozaki, Atsushi, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Yagyu, Shigeki, additional, Iehara, Tomoko, additional, and Otsuji, Eigo, additional

Published
2023
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39. Mott transition in the Hubbard model on the anisotropic kagom\'e lattice

Author

Furukawa, Yuta, Ohashi, Takuma, Koyama, Yohta, and Kawakami, Norio

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the Mott transition in the anisotropic kagom\'e lattice Hubbard model using the cellular dynamical mean field theory combined with continuous-time quantum Monte Carlo simulations. By calculating the double occupancy and the density of states, we determine the interaction strength of the first-order Mott transition and show that it becomes small as the anisotropy increases. We also calculate the spin correlation functions and the single-particle spectrum, and reveal that the quasiparticle and magnetic properties change dramatically around the Mott transition; the spin correlations are strongly enhanced and the quasiparticle bands are deformed. We conclude that such dramatic changes are due to the enhancement of anisotropy associated with the relaxation of frustration around the Mott transition., Comment: 4 pages, 6 figures

Published
2010
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40. Quantum condensation in electron-hole bilayers with density imbalance

Author

Yamashita, Kazuo, Asano, Kenichi, and Ohashi, Takuma

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We study the two-dimensional spatially separated electron-hole system with density imbalance at absolute zero temperature. By means of the mean-field theory, we find that the Fulde-Ferrell state is fairly stabilized by the order parameter mixing effect., Comment: 5 pages, 5 figures

Published
2009
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41. Lymphovascular invasion is associated with poor long-term outcomes in patients with pT1N0-3 or pT2-3N0 remnant gastric cancer: a retrospective cohort study.

Author

Sumiyoshi, Shutaro, Ohashi, Takuma, Kubota, Takeshi, Nishibeppu, Keiji, Owada, Kaho, Kiuchi, Jun, Shimizu, Hiroki, Arita, Tomohiro, Iitaka, Daisuke, Yamamoto, Yusuke, Konishi, Hirotaka, Morimura, Ryo, Watanabe, Kenji, Kuriu, Yoshiaki, Shiozaki, Atsushi, Ikoma, Hisashi, Fujiwara, Hitoshi, Yamaoka, Nobuki, and Otsuji, Eigo

Subjects
*STOMACH cancer, *PROPORTIONAL hazards models, *TREATMENT effectiveness, *ADJUVANT chemotherapy, *COHORT analysis
Abstract

Background: Lymphovascular invasion (LVI) is a poor prognostic factor in various malignancies. However, its prognostic effect in remnant gastric cancer (RGC) remains unclear. We examined the correlation between LVI and disease prognosis in patients with T1N0-3 or T2-3N0 RGC in whom adjuvant chemotherapy was not indicated and a treatment strategy was not established. Methods: We retrospectively analyzed patients with T1N0-3 and T2-3N0 RGC who underwent curative surgery at the Kyoto Prefectural University of Medicine between 1997 and 2019 and at the Kyoto Chubu Medical Center between 2009 and 2019. Results: Fifteen of 38 patients (39.5%) with RGC were positive for LVI. Patients with LVI had a significantly poorer prognosis for both overall survival ([OS]: P = 0.006) and recurrence-free survival ([RFS]: P = 0.001) than those without LVI. Multivariate analyses using the Cox proportional hazards model revealed LVI as an independent prognostic factor affecting OS (P = 0.024; hazard ratio 8.27, 95% confidence interval:1.285–161.6) and RFS (P = 0.013; hazard ratio 8.98, 95% confidence interval:1.513–171.2). Conclusions: LVI is a prognostic factor for patients with T1N0-3 or T2-3N0 RGC. Evaluating LVI may be useful for determining treatment strategies for RGC. [ABSTRACT FROM AUTHOR]

Published
2024
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42. MO49-1 The efficacy of high-dose versus intrathecal methotrexate for DLBCL with high risk of CNS relapse: A multicenter retrospective study

Author

Akimoto, Masahiro, primary, Miyazaki, Takuya, additional, Takahashi, Hiroyuki, additional, Saigusa, Yusuke, additional, Takeda, Takaaki, additional, Hibino, Yuto, additional, Tokunaga, Mayumi, additional, Ohashi, Takuma, additional, Matsumura, Ayako, additional, Teshigawara, Haruka, additional, Suzuki, Taisei, additional, Teranaka, Hiroshi, additional, Nakajima, Yuki, additional, Matsumoto, Kenji, additional, Hashimoto, Chizuko, additional, Fujimaki, Katsumichi, additional, Fujita, Hiroyuki, additional, Sakai, Rika, additional, Fujisawa, Shin, additional, and Nakajima, Hideaki, additional

Published
2023
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43. Preoperative oral antibiotic administration in patients undergoing curative resection with stoma creation for colorectal cancer: effectiveness in preventing surgical site infection and the possibility of peristomal candidiasis induced by enterobacterial alteration

Author

Kiuchi, Jun, primary, Kuriu, Yoshiaki, additional, Arita, Tomohiro, additional, Shimizu, Hiroki, additional, Nanishi, Kenji, additional, Takaki, Wataru, additional, Ohashi, Takuma, additional, Konishi, Hirotaka, additional, Yamamoto, Yusuke, additional, Morimura, Ryo, additional, Shiozaki, Atsuishi, additional, Ikoma, Hisashi, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, and Otsuji, Eigo, additional

Published
2023
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44. Spatial fluctuations of spin and orbital in two-orbital Hubbard model

Author

Kita, Tomoko, Ohashi, Takuma, and Suga, Sei-ichiro

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the quasiparticle dynamics in the two-orbital Hubbard model on the square lattice at quarter filling by means of the cellular dynamical mean field theory. We show that the Fermi-liquid state is stabilized up to the large Hubbard interactions in the symmetric case without the Hund's coupling, and find the heavy quasiparticles around the metal-insulator boundary. It is elucidated that the Hund's coupling enhances the antiferro-orbital correlations, which give rise to the pseudo gap behavior in the single-particle excitations. We also find the nonmonotonic temperature dependence in the quasiparticle dynamics for intermediate strength of the Hund's coupling, and clarify that it is caused by the competition between the Fermi-liquid formation and the antiferro-orbital fluctuations., Comment: 6 pages, 7 figures, revised version accepted for publication in Phys. Rev. B

Published
2008
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45. Finite-Temperature Mott Transition in Two-Dimensional Frustrated Hubbard Models

Author

Ohashi, Takuma, Momoi, Tsutomu, Tsunetsugu, Hirokazu, and Kawakami, Norio

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the Hubbard model on two typical frustrated lattices in two dimensions, the kagome lattice and the anisotropic triangular lattice, by means of the cellular dynamical mean field theory. We show that the metallic phase is stabilized up to fairly large Hubbard interactions under strong geometrical frustration in both cases, which results in heavy fermion behavior and several anomalous properties around the Mott transition point. In particular, for the anisotropic triangular lattice, we find novel reentrant behavior in the Mott transition in the moderately frustrated parameter regime, which is caused by the competition between Fermi-liquid formation and magnetic correlations. It is demonstrated that the reentrant behavior is a generic feature inherent in the Mott transition with intermediate geometrical frustration, and indeed in accordance with recent experimental findings for organic materials., Comment: 20 pages, 19 figures, to be published in the proceedings of YKIS2007 conference as a special issue of Prog. Theor. Phys. Suppl

Published
2008
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46. Three-orbital Kondo effect in single quantum dot system with plural electrons

Author

Kita, Tomoko, Sakano, Rui, Ohashi, Takuma, and Suga, Sei-ichiro

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We study the Kondo effect and related transport properties in orbitally degenerate vertical quantum dot systems with plural electrons. Applying the non-crossing approximation to the three-orbital Anderson impurity model with the finite Coulomb interaction and Hund-coupling, we investigate the magnetic-field dependence of the conductance and thermopower. We also introduce an additional orbital splitting to take account of the realistic many-body effect in the vertical quantum dot system. It is clarified how the three-orbital Kondo effect influences the transport properties via the modulation of the Kondo temperature and unitary limit of transport quantities due to the change of the symmetry in the system., Comment: 11 pages, 10 figures, accepted for publication in J. Phys. Soc. Jpn

Published
2008
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47. Finite temperature Mott transition in Hubbard model on anisotropic triangular lattice

Author

Ohashi, Takuma, Momoi, Tsutomu, Tsunetsugu, Hirokazu, and Kawakami, Norio

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the Hubbard model on the anisotropic triangular lattice by means of the cellular dynamical mean field theory. The phase diagram determined in the Hubbard interaction versus temperature plane shows novel reentrant behavior in the Mott transition due to the competition between Fermi-liquid formation and magnetic correlations under geometrical frustration. We demonstrate that the reentrant behavior is characteristic of the Mott transition with intermediate geometrical frustration and indeed consistent with recent experimental results of organic materials., Comment: 5 pages, 6 figures

Published
2007
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48. Magnetic correlations around the Mott transition in the Kagom\'e lattice Hubbard model

Author

Ohashi, Takuma, Suga, Sei-ichiro, Kawakami, Norio, and Tsunetsugu, Hirokazu

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We study the magnetic properties around the Mott transition in the Kagom\'e lattice Hubbard model by the cellular dynamical mean field theory combined with quantum Monte Carlo simulations. By investigating the q-dependence of the susceptibility, we find a dramatic change of the dominant spin fluctuations around the Mott transition. The spin fluctuations in the insulating phase favor down to the lowest temperature a spatial spin configuration in which antiferromagnetic correlations are strong only in one chain direction but almost vanishing in the others., Comment: 6 pages, 4 figures, accepted for publication in J. Phys. Condens. Matter. (Proceedings of Highly Frustrated Magnetism 2006)

Published
2006
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49. Anomalous magnetic properties near Mott transition in Kagom\'e lattice Hubbard model

Author

Ohashi, Takuma, Suga, Sei-ichiro, Kawakami, Norio, and Tsunetsugu, Hirokazu

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the characteristics of the metallic phase near the Mott transition in the Kagom\'e lattice Hubbard model using the cellular dynamical mean field theory. By calculating the specific heat and spin correlation functions, we demonstrate that the quasiparticles show anomalous properties in the metallic phase close to the Mott transition. We find clear evidence for the multi-band heavy quasiparticles in the specific heat, which gives rise to unusual temperature dependence of the spin correlation functions., Comment: 2 pages, 3 figures, accepted for publication in J. Mag. Mag. Mater. (Proceedings of the ICM, Kyoto, Japan, August 2006)

Published
2006
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50. Non-Crossing Approximation Study of Multi-Orbital Kondo Effect in Quantum Dot Systems

Author

Kita, Tomoko, Sakano, Rui, Ohashi, Takuma, and Suga, Sei-ichiro

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract

We study the three-orbital Kondo effect in quantum dot (QD) systems by applying the non-crossing approximation to the three-orbital Anderson impurity model. By investigating the tunneling conductance through a QD, we show that the competition between the Hund-coupling and the orbital level-splitting gives rise to characteristic behavior in transport properties. It is found that the Hund-coupling becomes more important in the three-orbital case than in the two-orbital case. We also show that the enhancement of Kondo temperature due to the singlet-triplet mechanism suggested for the two-orbital model tends to be suppressed by the existence of the third orbital., Comment: 6 pages, 5 figures, submitted to the Proceedings of the International Symposium on Mesoscopic Superconductivity and Spintronics 2006 (MS+S2006)

Published
2006

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