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This paper is concerned with the problem of H ∞ filtering for discrete-time Markov jump linear system with parametric uncertainties and quantized measurements, when the jumping mode information is not accessible. By converting the quantized errors into a sector-bounded nonlinearity, the parametric uncertainties and measurements quantization are dealt with in a unified framework. The mode-independent H ∞ filter is designed, and sufficient conditions are established via Lyapunov function approach, such that for all possible uncertain parameters and quantization errors, the resulting filtering error system is robustly stochastically stable and achieves a guaranteed H ∞ filtering error performance index. A numerical example is provided to demonstrate the feasibility and effectiveness of the proposed approach. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The problem of robust H∞ filtering is investigated for discrete-time Markov jump linear system (DMJLS) with uncertain parameters and missing measurements. The missing measurements process is modelled as a Bernoulli distributed sequence. A robust H∞ filter is designed and sufficient conditions are established in terms of linear matrix inequalities via a mode-dependent Lyapunov function approach, such that, for all admissible uncertain parameters and missing measurements, the resulting filtering error system is robustly stochastically stable and a guaranteed H∞ performance constraint is achieved. Furthermore, the optimal H∞ performance index is subsequently obtained by solving a convex optimisation problem and the missing measurements effects on the H∞ performance are evaluated. A numerical example is given to illustrate the feasibility and effectiveness of the proposed filter. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression of cluster of differentiation 44 variant 6 (CD(44V6)) and proliferating cell nuclear antigen (PCNA) in ocular squamous cell carcinomas., Methods: Streptavidin-biotin complex (SABC) immunohistochemistry was used to explore the expression of CD(44V6) and PCNA in 35 cases of ocular squamous cell carcinomas, 20 cases of papillomas, and 11 cases of normal eyelid tissue., Results: The CD(44V6) positive rate was 62.9% (22/35) in ocular squamous cell carcinomas, 15.0% (3/20) in papillomas, but not detectable in the 11 cases of normal eyelid tissue. The positive expression rates of CD(44V6) in ocular squamous cell carcinomas were significantly higher than in benign tumors (chi(2) = 11.57, P < 0.01) or control tissue (P = 0.001), and the positive expression rates of CD(44V6) in metastasis were significantly higher than without metastasis (P = 0.049). PCNA labeling indexes (PI) in tumors with CD(44V6) expression were significantly higher than those without (t = 20.21, P < 0.01)., Conclusions: Overexpression of CD(44V6) is correlated with the progress and metastasis of ocular squamous cell carcinomas. CD(44V6) protein positive staining is associated with high PI. CD(44V6) and PCNA are useful for evaluating prognosis.

Objective: To evaluate the therapeutic effect of basic fibroblast growth factor (bFGF) injected into the vitreous cavity on experimental retinal ischemia/reperfusion injury., Method: The Wistar rat model of experimental retinal ischemia/reperfusion injury was made by increasing the intraocular pressure. The rats were divided into normal, ischemia and treatment groups randomly. At the beginning of reperfusion, normal saline was injected into the vitreous cavity in ischemia group and 2 micro g of bFGF was injected into the treatment group. The histological and ultrastructural changes in retina of different time after reperfusion were observed. The retinal ganglion cell number was counted by using microscope. The thickness of inner layer of retina was measured by using Image Diagnosis System., Result: In the early period of retinal ischemia/reperfusion injury, the edematous status of retina of treatment group was lighter than that of the ischemia group. The retinal inner layer thickness and the RGC number of treatment group were greater than that of the ischemia group during all the post-reperfusion stages. At 168 hours after reperfusion, the thickness of the retinal nerve fiber layer and the RGC numbers of ischemia groups were obviously lower than that of the normal groups. But the differences of thickness of the nerve fiber layer and RGC number between the treatment and normal group were of no statistical importance. The nuclear membranes of RGCs were edematous and the mitochondrial cristae were unclear at 24th hour after reperfusion, the apoptotic body can be found, and the microtubules in nerve fibers became unclear and even disappeared in the ischemic group. While in the treatment group, the nucleus was clear, only part of the nuclear membrane was edematous, the cell organs were abundant and the structures of mitochondria and microtubules were clear., Conclusion: Injection of bFGF into the vitreous cavity has the therapeutic effect on experimental retinal ischemia/reperfusion injury.

Objective: To investigate the relationship between P16 gene (the tumor suppressor gene) and the bcl-2 gene (the apoptosis inhibitor gene) and the incidence and development of malignant eyelid tumors., Methods: The streptavidin-biotin-peroxidase complex immunohistochemistry method was used to study the expression of P16 gene and the bcl-2 gene in 96 cases of malignant eyelid tumors., Results: Among the 96 cases, there were 40 basal cell carcinomas (BCCs), 33 squamous carcinomas and 23 sebaceous carcinoma, with P16 protein positive (nuclear staining) rates 70%, 54.6% and 56.5%, respectively. The P16 positive rate was negatively correlated with the degree of tumor histological differentiation, and the rate difference between the high differentiated carcinomas was significant (P < 0.05). Positive Bcl-2 protein expression was detected in the cytoplasm. All 40 BCC cases were Bcl-2 positive, and nearly all of the tumor cells showed positive cytoplasmic expression, while in the 33 squamous cell carcinoma cases only one showed positive focal reaction, and the staining in the other 32 cases was relatively faint. None of the 23 sebaceous carcinomas expressed Bcl-2., Conclusions: The expression of the P16 protein was related to the occurrence and degree of differentiation of malignant eyelid tumors. The overexpression of the Bcl-2 protein suggests that suppression of apoptosis might play a role in the tumorigenesis of BCC.