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4. Cover

Author

Nishiyama, Takashi

Published
2014

16. Notes

Author

Nishiyama, Takashi

Published
2014

20. Index

Author

Nishiyama, Takashi

Published
2014

27. Incidence and Risk Factors of Immediate Hypersensitivity Reactions and Immunization Stress-Related Responses With COVID-19 mRNA Vaccine

Author

Imai, Kazuo, Tanaka, Fumika, Kawano, Shuichi, Esaki, Kotoba, Arakawa, Junko, Nishiyama, Takashi, Seno, Soichiro, Hatanaka, Kosuke, Sugiura, Takao, Kodama, Yu, Yamada, Seigo, Iwamoto, Shinichiro, Takeshima, Shigeto, Abe, Nobujiro, Kamae, Chikako, Aono, Shigeaki, Ito, Toshimitsu, Yamamoto, Tetsuo, and Mizuguchi, Yasunori

Published
2022
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32. Progress on the Synthesis of the Aromathecin Family of Compounds: An Overview.

Author

Nishiyama, Takashi, Mizuno, Shota, Hieda, Yuhzo, and Choshi, Tominari

Subjects
*FAMILIES, *MOIETIES (Chemistry), *PYRIDONE, *PYRROLIDINE, *PYRIDINE
Abstract

We present a systematic review of the methods developed for the synthesis of the aromathecin family of compounds (benz[6,7]indolizino[1,2-b]quinolin-11(13H)-ones) and their derivatives. These methods can be broadly classified into four categories based on the construction of pentacyclic structures: Category 1: by constructing a pyridone moiety (D-ring) on the pyrroloquinoline ring (A/B/C-ring), Category 2: by constructing a pyridine moiety (B-ring) on the pyrroloisoquinolone ring (C/D/E-ring), Category 3: by constructing an indolizidinone moiety (C/D-ring) in a tandem reaction, and Category 4: by constructing a pyrrolidine moiety (C-ring) on the isoquinolone ring (D/E-ring). [ABSTRACT FROM AUTHOR]

Published
2024
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36. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Author

Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B, and Hoshi, Minako

Subjects
Alzheimer's Disease, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Neurosciences, Dementia, Aging, Acquired Cognitive Impairment, Aetiology, 2.1 Biological and endogenous factors, Neurological, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Peptides, Animals, Calcium, Cell Death, Cells, Cultured, HEK293 Cells, Homeostasis, Humans, Mass Spectrometry, Models, Biological, Models, Molecular, Molecular Imaging, Molecular Sequence Data, Molecular Weight, Neurons, Peptides, Protein Aggregates, Protein Binding, Rats, Signal Transduction, Sodium, Sodium-Potassium-Exchanging ATPase, NMR, computational modeling, abnormal protein-protein interaction in synapse, hyperexcitotoxicity, protein-protein interaction inhibitors, abnormal protein–protein interaction in synapse, protein–protein interaction inhibitors
Abstract

Neurodegeneration correlates with Alzheimer's disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that cause selective degeneration of mature neurons. Here, we show that the ASPD target is neuron-specific Na(+)/K(+)-ATPase α3 subunit (NAKα3). ASPD-binding to NAKα3 impaired NAKα3-specific activity, activated N-type voltage-gated calcium channels, and caused mitochondrial calcium dyshomeostasis, tau abnormalities, and neurodegeneration. NMR and molecular modeling studies suggested that spherical ASPD contain N-terminal-Aβ-derived "thorns" responsible for target binding, which are distinct from low molecular-weight oligomers and dodecamers. The fourth extracellular loop (Ex4) region of NAKα3 encompassing Asn(879) and Trp(880) is essential for ASPD-NAKα3 interaction, because tetrapeptides mimicking this Ex4 region bound to the ASPD surface and blocked ASPD neurotoxicity. Our findings open up new possibilities for knowledge-based design of peptidomimetics that inhibit neurodegeneration in AD by blocking aberrant ASPD-NAKα3 interaction.

Published
2015

50. Effect of intravenous fluid therapy for acute alcohol intoxication on length of time from arrival at the emergency department until awakening: A prospective observational cohort study

Author

Terayama, Takero, primary, Sasa, Ruka, additional, Nakatani, Yuka, additional, Tanaka, Fumika, additional, Terashige, Sho, additional, Higashiyama, Daishi, additional, Sugiura, Takao, additional, Hatanaka, Kosuke, additional, Nishiyama, Takashi, additional, and Takeshima, Shigeto, additional

Published
2023
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