39 results on '"Newitt, John A."'
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2. Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
3. Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1
4. The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer
5. Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay
6. Assessing compound binding to the Eg5 motor domain using a thermal shift assay
7. Native Mass Spectrometry and Gas-Phase Fragmentation Provide Rapid and In-Depth Topological Characterization of a PROTAC Ternary Complex
8. Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1)
9. Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis
10. The structure and multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins
11. The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins
12. Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
13. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
14. The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode
15. Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity
16. Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor
17. Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer
18. Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions
19. Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening
20. Discovery of pyrrolo[2,1- f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors
21. 5-Amino-pyrazoles as potent and selective p38α inhibitors
22. Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors
23. The discovery of ( R)-2-( sec-butylamino)- N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)—A potent and efficacious p38α MAP kinase inhibitor
24. Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases
25. Multiple and Single Binding Modes of Fragment-Like Kinase Inhibitors Revealed by Molecular Modeling, Residue Type-Selective Protonation, and Nuclear Overhauser Effects
26. Structural basis for the high-affinity binding of pyrrolotriazine inhibitors of p38 MAP kinase
27. Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors
28. Discovery of Novel P1 Groupsfor Coagulation FactorVIIa Inhibition Using Fragment-Based Screening.
29. Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors
30. The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants
31. Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series
32. The Crystal Structure of Abl Kinase with BMS-354825, a Dual SRC/ABL Kinase Inhibitor.
33. The Structure of Multiple Polypeptide Domains Determines the Signal Recognition Particle Targeting Requirement of Escherichia coli Inner Membrane Proteins
34. A Mutation in the Escherichia coli secY Gene That Produces Distinct Effects on Inner Membrane Protein Insertion and Protein Export
35. The N-Domain of the Signal Recognition Particle 54-kDa Subunit Promotes Efficient Signal Sequence Binding
36. The E. coli signal recognition particle is required for the insertion of the subset of inner...
37. A Highly Conserved Nucleotide in the Alu Domain of SRP RNA Mediates Translation Arrest through High Affinity Binding to SRP9/14.
38. A Mutation in the Escherichia coli secYGene That Produces Distinct Effects on Inner Membrane Protein Insertion and Protein Export*
39. Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
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