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195 results on '"Napodano, Cecilia"'

1. Spotlight on Syndecan 1 Role in Systemic Autoimmune Rheumatic Diseases: Main Actor or Guest Appearance?

Author

Carnazzo, Valeria, primary, Gulli, Francesca, additional, Basile, Valerio, additional, Di Santo, Riccardo, additional, Niccolini, Benedetta, additional, Redi, Serena, additional, Vinante, Ilaria, additional, Napodano, Cecilia, additional, Pocino, Krizia, additional, Rapaccini, Gian Ludovico, additional, Marino, Mariapaola, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2024
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3. Salivary biomarkers in COVID-19 patients: the rabbit out of the hat!

Author

Napodano, Cecilia, primary, Callà, Cinzia Anna, additional, Fiorito, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Cesare, Tiziana Di, additional, Passali, Giulio Cesare, additional, Santo, Riccardo Di, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2024
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8. Serological and Molecular Characterization of Hepatitis C Virus-Related Cryoglobulinemic Vasculitis in Patients without Cryoprecipitate

Author

Napodano, Cecilia, primary, Ciasca, Gabriele, additional, Chiusolo, Patrizia, additional, Pocino, Krizia, additional, Gragnani, Laura, additional, Stefanile, Annunziata, additional, Gulli, Francesca, additional, Lorini, Serena, additional, Minnella, Gessica, additional, Fosso, Federica, additional, Di Santo, Riccardo, additional, Romanò, Sabrina, additional, Basile, Valerio, additional, De Stefano, Valerio, additional, Rapaccini, Gian Ludovico, additional, Zignego, Anna Linda, additional, Di Stasio, Enrico, additional, Marino, Mariapaola, additional, and Basile, Umberto, additional

Published
2023
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10. Free light chains: novel serum biomarkers for NASH stratification, an update

Author

Liguori, Antonio, primary, Basile, Umberto, additional, D’Ambrosio, Francesca, additional, Napodano, Cecilia, additional, Tomasello, Lidia, additional, Mancuso, Fabrizio, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Rapaccini, Gianludovico, additional, Gasbarrini, Antonio, additional, Grieco, Antonio, additional, and Miele, Luca, additional

Published
2023
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12. Urinary lithogenic profile of patients with non-alcoholic fatty liver disease

Author

Bargagli, Matteo, primary, Liguori, Antonio, additional, Napodano, Cecilia, additional, Baroni, Silvia, additional, Tomasello, Lidia, additional, Pizzolante, Fabrizio, additional, De Matthaeis, Nicoletta, additional, De Ninno, Grazia, additional, Grieco, Antonio, additional, Gasbarrini, Antonio, additional, Gambaro, Giovanni, additional, Ferraro, Pietro Manuel, additional, and Miele, Luca, additional

Published
2023
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13. Laboratory and Clinical Settings of Heavy/Light Chain (HLC) Assays in the Management of Monoclonal Gammopathies and Multiple Myeloma

Author

Napodano, Cecilia, primary, Ioannilli, Laura, additional, Basile, Valerio, additional, Gulli, Francesca, additional, Carnazzo, Valeria, additional, Pignalosa, Stefano, additional, Di Biase, Luigi, additional, Cavaleri, Erica, additional, Racco, Cosimo, additional, Equitani, Francesco, additional, Marino, Mariapaola, additional, and Basile, Umberto, additional

Published
2023
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15. Crioproteinemia: nuove frontiere per i clinici e il laboratorio.

Author

Natali, Patrizia, Debbia, Daria, Troiano, Teresa, Napodano, Cecilia, Spinella, Amelia, Amati, Gabriele, Filippini, Davide, Zani, Roberta, Alfano, Gaetano, Colaci, Elisabetta, Maccaferri, Monica, Galassi, Giuliana, Mazzoli, Marco, Ariatti, Alessandra, Basile, Umberto, Mascia, Maria Teresa, Palladini, Giovanni, Giuggioli, Dilia, and Sandri, Gilda

Abstract

Cryoproteinaemia is characterised by the presence of detectable proteins in both serum and plasma that precipitate at 4°C and dissolve at 37°C. Cryoglobulins are constituted by immunoglobulins and are detectable in both serum and plasma, whereas cryofibrinogen is detectable only in plasma. The importance of studying cryoproteinemia was the main theme of the meeting held in Modena in March 2023, entitled: Cryoglobulinemia. Laboratory and clinic, a fruitful collaboration for the correct management of a rare pathology - 4th edition, organised by the Italian Society of Clinical Biochemistry and Molecular Biology (SIBioC) and the Italian Association for the fight against Cryoglobulinaemia (ALCRI). The aim of this conference is to promote a dialogue between clinicians and laboratory professionals, highlighting the information that the clinician expects from the laboratory and the critical points that the laboratory faces when performing a test that is still predominantly performed manually. During the meeting, data from three laboratories were presented and compared, and a group of clinicians who deal with cryoproteinemia in different medical fields -- rheumatologists, nephrologists, haematologists, and neurologists -- contributed their experience in treating patients with cryoproteinemia. The collaboration between laboratory and clinic and the respective scientific societies (SIBioC and ALCRI) have made possible to draw a common line to guide both entities in their daily activity. The road seems long and complex, but a common system is emerging from this interaction, the fruits from which patient will benefit. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace

Author

Pocino, Krizia, primary, Stefanile, Annunziata, additional, Basile, Valerio, additional, Napodano, Cecilia, additional, D’Ambrosio, Francesca, additional, Di Santo, Riccardo, additional, Callà, Cinzia Anna Maria, additional, Gulli, Francesca, additional, Saporito, Raffaele, additional, Ciasca, Gabriele, additional, Equitani, Francesco, additional, Basile, Umberto, additional, and Marino, Mariapaola, additional

Published
2022
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19. Circulating and Salivary NGF and BDNF Levels in SARS-CoV-2 Infection: Potential Predictor Biomarkers of COVID-19 Disease—Preliminary Data

Author

Biamonte, Filippo, primary, Re, Agnese, additional, Balzamino, Bijorn Omar, additional, Ciasca, Gabriele, additional, Santucci, Daniela, additional, Napodano, Cecilia, additional, Nocca, Giuseppina, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Basile, Umberto, additional, Micera, Alessandra, additional, and Callà, Cinzia Anna Maria, additional

Published
2022
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20. PMON255 Inflammation and Oxidative Stress in Seminal Plasma: Role of Free Light Chains of Immunoglobulins and Antioxidants as Biomarkers in Male Infertility

Author

Bruno, Carmine, primary, Vergani, Edoardo, additional, Oliva, Alessandro, additional, Basile, Umberto, additional, Napodano, Cecilia, additional, Gulli, Francesca, additional, Silvestrini, Andrea, additional, Meucci, Elisabetta, additional, Orlando, Patrick, additional, Silvestri, Sonia, additional, Tiano, Luca, additional, and Mancini, Antonio, additional

Published
2022
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21. Free Light Chains as a potential biomarker of inflammation and fibrosis in non-alcoholic steatohepatitis

Author

Liguori, Antonio, primary, Basile, Umberto, additional, Napodano, Cecilia, additional, Tomasello, Lidia, additional, Mancuso, Fabrizio, additional, Di Gialleonardo, Luca, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Gasbarrini, Antonio, additional, Rapaccini, Gian Ludovico, additional, Grieco, Antonio, additional, and Miele, Luca, additional

Published
2022
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24. Inflammation and Oxidative Stress in Seminal Plasma: Search for Biomarkers in Diagnostic Approach to Male Infertility

Author

Bruno, Carmine, primary, Basile, Umberto, additional, Vergani, Edoardo, additional, Napodano, Cecilia, additional, Oliva, Alessandro, additional, Gulli, Francesca, additional, Meucci, Elisabetta, additional, Silvestrini, Andrea, additional, Orlando, Patrick, additional, Silvestri, Sonia, additional, Tiano, Luca, additional, and Mancini, Antonio, additional

Published
2022
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26. Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace.

Author

Pocino, Krizia, Stefanile, Annunziata, Basile, Valerio, Napodano, Cecilia, D'Ambrosio, Francesca, Di Santo, Riccardo, Callà, Cinzia Anna Maria, Gulli, Francesca, Saporito, Raffaele, Ciasca, Gabriele, Equitani, Francesco, Basile, Umberto, and Marino, Mariapaola

Subjects
HEPATOCELLULAR carcinoma, SOMATIC mutation, CYTOKINES, GROWTH factors, ANGIOPOIETINS
Abstract

Hepatocellular carcinoma (HCC) represents a worldwide health matter with a major care burden, high prevalence, and poor prognosis. Its pathogenesis mainly varies depending on the underlying etiological factors, although it develops from liver cirrhosis in the majority of cases. This review summarizes the role of the most interesting soluble factors as biomarkers for early diagnosis and as recommended targets for treatment in accordance with the new challenges in precision medicine. In the premalignant environment, inflammatory cells release a wide range of cytokines, chemokines, growth factors, prostaglandins, and proangiogenic factors, making the liver environment more suitable for hepatocyte tumor progression that starts from acquired genetic mutations. A complex interaction of pro-inflammatory (IL-6, TNF-α) and anti-inflammatory cytokines (TGF-α and -β), pro-angiogenic molecules (including the Angiopoietins, HGF, PECAM-1, HIF-1α, VEGF), different transcription factors (NF-kB, STAT-3), and their signaling pathways are involved in the development of HCC. Since cytokines are expressed and released during the different stages of HCC progression, their measurement, by different available methods, can provide in-depth information on the identification and management of HCC. [ABSTRACT FROM AUTHOR]

Published
2023
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35. The diagnostic performance of PIVKA-II in metabolic and viral hepatocellular carcinoma: a pilot study

Author

Basile, Umberto, Miele, Luca, Napodano, Cecilia, Ciasca, Gabriele, Gulli, F., Pocino, Krizia, De Matthaeis, Nicoletta, Liguori, Antonio, DE MAGISTRIS, A., Marrone, Giuseppe, Biolato, Marco, Marino, Mariapaola, Di Giacinto, Flavio, Gasbarrini, Antonio, Grieco, Antonio, and Rapaccini, Gian Ludovico

Subjects
Carcinoma, Hepatocellular, Settore MED/12 - GASTROENTEROLOGIA, Liver Neoplasms, Pilot Projects, Metabolic Hepatocellular carcinoma, Settore MED/05 - PATOLOGIA CLINICA, α-fetoprotein, PIVKA-II, Biomarkers, Tumor, Viral Hepatocellular carcinoma, Humans, Prothrombin, alpha-Fetoproteins, Protein Precursors, Biomarkers
Abstract

Hepatocellular carcinoma (HCC) is a primary liver tumor derived from metabolic or viral chronic hepatitis, with few treatment options in advanced cases. New biomarkers that allow improving diagnosis and staging are widely desired. Here, we aim to evaluate the performance of Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) in combination with α-fetoprotein (AFP), in the diagnosis of HCC in patients with metabolic or viral hepatitis.We enrolled 60 HCC patients (20 metabolic and 40 viral) and 20 healthy subjects (HS) as negative controls. PIVKA-II, AFP, Matrix metalloproteinase-9 (MMP-9) and Fibroblast growth factor (FGF) serum levels were assessed by immunoassays.AFP and PIVKA-II levels were obviously higher in patients than in HS. AFP displayed a better diagnostic performance than PIVKA-II for viral HCC while PIVKA-II was better for metabolic HCC. The combination of the two biomarkers did not improve the discriminating ability.PIVKA-II may be considered an independent predictor of macrovascular invasion from HCC cells and it can be used to better stratify HCC patients and should be evaluated in prospective studies for early detection of advanced HCC in metabolic subjects.

Published
2020

36. Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis

Author

Gragnani, Laura, primary, Lorini, Serena, additional, Marri, Silvia, additional, Basile, Umberto, additional, Santarlasci, Veronica, additional, Monti, Monica, additional, Madia, Francesco, additional, Petraccia, Luisa, additional, Stasi, Cristina, additional, Marello, Niccolò, additional, Napodano, Cecilia, additional, Annunziato, Francesco, additional, and Zignego, Anna Linda, additional

Published
2021
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37. Cryoglobulins: putative effectors of adaptive immune response

Author

Basile, Umberto, primary, Napodano, Cecilia, additional, Marino, Mariapaola, additional, Gulli, Francesca, additional, Colantuono, Stefania, additional, Casato, Milvia, additional, Pocino, Krizia, additional, Basile, Valerio, additional, Todi, Laura, additional, Rapaccini, Gian Ludovico, additional, and Visentini, Marcella, additional

Published
2021
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39. Salivary Biomarkers in COVID-19 Patients: Towards a Wide-Scale Test for Monitoring Disease Activity

Author

Napodano, Cecilia, primary, Callà, Cinzia, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Di Cesare, Tiziana, additional, Passali, Giulio Cesare, additional, Di Santo, Riccardo, additional, Stefanile, Annunziata, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2021
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41. Salivary Biomarkers in COVID-19 Patients: The Rabbit out of the Hat!

Author

Napodano, Cecilia, primary, Callà, Cinzia, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Di Cesare, Tiziana, additional, Passali, Giulio Cesare, additional, Disanto, Riccardo, additional, Stefanile, Annunziata, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2021
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43. Cryoglobulins: Identification, classification, and novel biomarkers of mysterious proteins

Author

Napodano, Cecilia, Gulli, F., Rapaccini, Gian Ludovico, Marino, Mariapaola, and Basile, Umberto

Subjects
Vasculitis, Cryoglobulin, COVID-19, Rheumatoid factor, Hepatitis C, Article, Mixed cryoglobulin, Settore MED/05 - PATOLOGIA CLINICA, Cryoglobulinemia, Animals, Chemical Precipitation, Humans, Cryoglobulins, Biomarkers, Autoantibodies
Abstract

Cryoglobulins consist of serum immunoglobulins that precipitate below 37°C and resolubilize upon warming. The clinical triad of cryoglobulinemia usually includes purpura, weakness, and arthralgia. Cryoglobulinemic syndrome, clinically defined as a systemic vasculitis, is associated with chronic infection with hepatitis C virus (HCV) and autoimmune disorders and can evolve into B-cell malignancies. While the current literature about HCV-associated cryoglobulinemia is not very limited, little is known about the immunologic and serologic profiles of affected patients. Therefore, comprehension of the pathogenetic mechanisms underlying cryoprecipitation could be very helpful. Due to the persistence of viral antigenic stimulation, biomarkers to use after the worsening progression of HCV infection to lymphoproliferative and/or autoimmune diseases are widely needed. Laboratory methods used to detect and characterize low concentrations of cryoprecipitates and immunotyping patterns could improve patient management. The most critical factor affecting cryoglobulin testing is that the pre-analytical phase is not fully completed at 37°C.

Published
2020

44. Evaluation of free light chains of immunoglobulins in normal and pathological seminal fluids: Preliminary data.

Author

Basile, Umberto, Vergan, Edoardo, Napodano, Cecilia, Bruno, Carmine, Marino, Mariapaola, Oliva, Alessandro, Gulli, Francesca, and Mancini, Antonio

Subjects
IMMUNOGLOBULIN light chains, IMMUNOGLOBULINS, SEMEN analysis, FLUIDS
Abstract

Immunoglobulins free light chains (FLCs) are assayable in several biological fluids. Currently, there are no reports on FLCs in seminal plasma. The aims of our study were to investigate the presence and detectability of FLCs in seminal plasma and to evaluate the usefulness of this assay in the diagnostic approach to infertile patients. We enrolled 61 patients aged 18-- 50 years. Semen analysis was performed. They were divided into four groups: controls-- normozoospermic, 10 patients, mean ± SEM age 35 ± 1.5 years; varicoceles (VAR), 18 patients aged 24.3 ± 0.96 years; inflammatory (INF) seminal fluids, 24 patients, aged 38.8 ± 2.2 years; and varicoceles and inflammatory (VAR/INF) seminal fluids, 9 patients, aged 29.5 ± 0.71 years. A trend towards higher λ FLCs levels was evidenced in the INF and VAR/INF groups. FLCs were higher in normozoospermic patients with lower levels in VAR, both isolated and associated with inflammatory parameters. This differential pattern of the two types of FLCs reached statistical significance when comparing /λ ratio, with significant lower levels in VAR vs controls. This is the first report of FLCs assay in seminal plasma. We can hypothesize that λ FLCs are increased in inflammatory processes, whether FLCs seem to be influenced by other molecular mechanisms related to varicocele. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Assessment of immunoglobulins free light chains in serum and urine of patients with system sclerosis: novel biomarkers for activity disease

Author

Gigante, Antonietta, primary, Pellicano, Chiara, additional, Leodori, Giorgia, additional, Napodano, Cecilia, additional, Vantaggio, Lorenzo, additional, Gulli, Francesca, additional, MARINO, Mariapaola, additional, Visentini, Marcella, additional, Rosato, Edoardo, additional, and Basile, Umberto, additional

Published
2021
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46. Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression

Author

Pocino, Krizia, primary, Napodano, Cecilia, additional, Gragnani, Laura, additional, Ciasca, Gabriele, additional, Colantuono, Stefania , additional, Marri, Silvia, additional, Vantaggio, Lorenzo, additional, Gulli, Francesca, additional, Lorini, Serena, additional, Barini, Antonella, additional, Stefanile, Annunziata, additional, Miele, Luca, additional, Casato, Milvia, additional, Zignego, Anna Linda, additional, Rapaccini, Gian Ludovico, additional, Marino, Mariapaola, additional, Visentini, Marcella, additional, and Basile, Umberto, additional

Published
2021
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47. Biomarkers in HCV-related mixed cryoglobulinemia patients withnon-Hodgkin lymphoma

Author

Gulli, F., Marino, Mariapaola, Napodano, Cecilia, Pocino, Krizia, Pandolfi, Franco, Gasbarrini, Antonio, Rapaccini, Gian Ludovico, and Basile, Umberto

Subjects
Male, Hepatitis C virus, Lymphoma, Non-Hodgkin, Settore MED/12 - GASTROENTEROLOGIA, Hepacivirus, Middle Aged, B cell non-Hodgkin's lymphoma, Mixed cryoglobulins, Syndecan-1 (CD138), Settore MED/05 - PATOLOGIA CLINICA, FLC, Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, Cryoglobulinemia, Biomarkers, Tumor, Humans, Female, Immunoglobulin Light Chains, Syndecan-1, Biomarkers, Retrospective Studies
Abstract

Chronic Hepatitis C virus (HCV) infection can cause severe extrahepatic manifestations, such as mixed cryoglobulins (MC), up to the development of B cell nonHodgkin's lymphoma (B-NHL). Mechanisms transforming of HCV infection into lymphoproliferative and/or autoimmune disorders are still poorly understood. In course of HCV infection, the sustained virus-driven antigenic stimulation may probably induce a B-cell clonal expansion. Measurements of serum free light chains (FLCs) levels, considered as a direct marker of B cell activity, are analyzed with increasing interest in clinical practice, for diagnosis, monitoring and follow-up of plasma cell dyscrasia. Syndecan-1 (CD138) is a transmembrane heparan sulfate proteoglycan expressed and actively shed by most myeloma cells. Membrane CD138 represents the major receptor protein for HCV attachment to the hepatocyte surface and high levels of circulating sCD138 levels are detected in patients at early stage of B-cell chronic lymphocytic leukemia. This study is aimed to evaluate sCD138 and FLC levels as diagnostic biomarkers of HCV-related MC with B-NHL.We enrolled 35 HCV-MC-NHL patients, characterized for the specific type of cryoglobulins, and 25 healthy blood donors (HBD) as negative control. Serum sCD138 levels were determined using ELISA kits specific for human sCD138. Serum FLCs were assessed by means of the turbidimetric assay.We found that serum levels of sCD138, as well as FLCs, were significantly higher in patients than in HBD (p0.001).In agreement with the definition of HCV-driven lymphoproliferative disorders as the consequence of a multifactorial and multistep pathogenetic process, we suggest that sCD138 and FLCs could be considered putative independent markers of worsening progression of the disease.

Published
2020

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