291 results on '"Nalos, Marek"'
Search Results
2. How often are infusion sets for central venous catheters changed in Australian and New Zealand Intensive Care Units? A point prevalence survey
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Hammond, Naomi, Freeman-Sanderson, Amy, Ganu, Subodh, Howe, Belinda, Litton, Ed, Mackle, Diane, Saxena, Manoj, Seppelt, Ian, Towns, Miriam, Yarad, Elizabeth, Knowles, Serena, Gao, Annie, Li, Yang, Myburgh, John, Nangla, Conrad, Butt, Fatima, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Gilder, Eileen, Robertson, Melissa, McMahon, Ellie, Ali, Farisha, Cowdrey, Keri-Anne, McArthur, Colin, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, O'Connor, Caroline, El-Khawas, Khaled, Hill, Dianne, Cattigan, Claire, Horton, Michelle, Trickey, Jemma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Sara, Treena, Nand, Kiran, Ramanan, Mahesh, Marella, Prashanti, Affleck, Julia, Simpson, Shannon, Ellem, Katrina, McKenna, Toni, Nourse, Mary, Leung, Kristine, Edmunds, Tash, McDonald, Bree, Mehrtens, Jan, Cross, Rosalba, Wong, Helen, Twardowski, Pawel, France, Dawn, Hanlon, Gabrielle, Barrett, Jonathan, Palermo, Annamaria, Pellicano, Susan, Eroglu, Ege, Bihari, Shailesh, Brown, Julia, Grear, Laura, Jin, Xia, French, Craig, Bates, Samantha, Marshall, Fiona, McEldrew, Rebecca, McCullough, James, Tallott, Mandy, Gough, Maimoonbe, Nalos, Marek, Younger, Laura, Krishnamurphy, Ravi, Trent, Louise, How, Janet, Stuart, Anne, Chadwick, Llesley, Bhadange, Neeraj, Tyler, Steven, Sosnowski, Kellie, Morrison, Lynette, Sutton, Joanne, Soar, Natalie, Lee, David, Doyle, Marina, Jongebloed, Katherine, Finnis, Mackenzie, Wilson, Jane, Williams, Tony, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Habraken, Hannah, Browne, Alex, Koelle, Jette, McNab, Charlotte, Masters, Kristy, Gresham, Rebecca, Lowrey, Julie, Whitehead, Christina, Liang, Janet, Harward, Meg, Jones, Cassie, Peake, Sandra, Williams, Tricia, Kurenda, Catherine, Tabah, Alexis, Duroux, Maree, Warhurst, Timothy, Ratcliffe, Megan, Pollock, Hamish, Baker, Stuart, Sonawane, Ravikiran, O'Connor, Stephanie, Brown, Nerissa, Glasby, Kathleen, Rivett, Justine, Campbell, Lewis, Tabuzo, Vera, Smyth, Kirsty, Bass, Frances, O'Connor, Anne, Leonard, Anton, Waterson, Sharon, Coles, Jennifer, Buhr, Heidi, Newman, Duncan, Boorawong, Piyaporn, Bregolin, Vanessa, Yun, Ji-Hyun, Anstey, Matthew, Rock, Lara, Endemann, Anthadene, Lo, Wei, Ferrier, Janet, Reynolds, Claire, Santamaria, John, Holmes, Jennifer, Beca, John, Sherring, Claire, Garrett, Peter, Murray, Lauren, Brailsford, Jane, Browne, Troy, Goodson, Jennifer, Udy, Andrew, Young, Meredith, Board, Jasmin, McCracken, Phoebe, Martin, Emma-Leah, Martynoga, Robert, Butler, Amelia, Trask, Kara, Olatunji, Shaanti, Cruz, Rhoze Sol, Cruz, Raulle Sol, Navarra, Leanlove, Delaney, Kirsha, Lesona, Eden, Young, Chelsea, Spring, Amelia, Aguilar, April, Young, Paul, Law, Erin, Anstey, Matthew H., Maxwell, Nicky, Rickard, Claire M., Hammond, Naomi E., and McGain, Forbes
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- 2024
- Full Text
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3. Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
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Kjær, Maj-Brit Nørregaard, Meyhoff, Tine Sylvest, Sivapalan, Praleene, Granholm, Anders, Hjortrup, Peter Buhl, Madsen, Martin Bruun, Møller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jørn, Lange, Theis, Cronhjort, Maria, Laake, Jon Henrik, Jakob, Stephan M., Nalos, Marek, Ostermann, Marlies, Gould, Doug, Cecconi, Maurizio, Malbrain, Manu L. N. G., Ahlstedt, Christian, Kiel, Louise Bendix, Bestle, Morten H., Nebrich, Lars, Hildebrandt, Thomas, Russell, Lene, Vang, Marianne, Rasmussen, Michael Lindhart, Sølling, Christoffer, Brøchner, Anne Craveiro, Krag, Mette, Pfortmueller, Carmen, Kriz, Miroslav, Siegemund, Martin, Albano, Giovanni, Aagaard, Søren Rosborg, Bundgaard, Helle, Crone, Vera, Wichmann, Sine, Johnstad, Bror, Martin, Yvonne Karin, Seidel, Philipp, Mårtensson, Johan, Hollenberg, Jacob, Wistrand, Mats, Donati, Abele, Barbara, Enrico, Karvunidis, Thomas, Hollinger, Alexa, Carsetti, Andrea, Lumlertgul, Nuttha, Joelsson-Alm, Eva, Lambiris, Nikolas, Aslam, Tayyba Naz, Friberg, Fredrik Femtehjell, Vesterlund, Gitte Kingo, Mortensen, Camilla Bekker, Vestergaard, Stine Rom, Caspersen, Sidsel Fjordbak, Jensen, Diana Bertelsen, Borup, Morten, Rasmussen, Bodil Steen, and Perner, Anders
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- 2023
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4. Host transcriptomics and machine learning for secondary bacterial infections in patients with COVID-19: a prospective, observational cohort study
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Carney, Meagan, Pelaia, Tiana M, Chew, Tracy, Teoh, Sally, Phu, Amy, Kim, Karan, Wang, Ya, Iredell, Jonathan, Cirmena, Gabriella, Ballestrero, Alberto, Cripps, Allan, Cox, Amanda, De Maria, Andrea, Kulasinghe, Arutha, Feng, Carl, Chaussabel, Damien, Rinchai, Darawan, Bedognetti, Davide, Zoppoli, Gabriele, Gunawan, Gunawan, Thevarajan, Irani, Audsley, Jennifer, Eden, John-Sebastian, Kralovcova, Marcela, Nalos, Marek, Radic, Marko, Matejovic, Martin, Bedognetti, Michele, Prucha, Miroslav, Toufiq, Mohammed, Teluguakula, Narasaraju, West, Nicholas, Cremonesi, Paolo, Britton, Philip, Branco, Ricardo G, Bilyy, Rostyslav, MacDonald, Stephen, Karvunidis, Thomas, Kwan, Tim, Herwanto, Velma, Kuan, Win Sen, Zerbib, Yoann, McLean, Anthony, Schughart, Klaus, Tang, Benjamin, Shojaei, Maryam, Short, Kirsty R, and Pelaia, Tiana Maria
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- 2024
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5. How much do we throw away in the intensive care unit? An observational point prevalence study of Australian and New Zealand ICUs
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Hammond, Naomi, Knowles, Serena, Freeman-Sanderson, Amy, Ganu, Subodh, Howe, Belinda, Litton, Ed, Mackle, Diane, Saxena, Manoj, Seppelt, Ian, Towns, Miriam, Yarad, Elizabeth, Hammond, Gao, Annie, Li, Yang, Myburgh, John, Nangla, Conrad, Butt, Fatima, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Gilder, Eileen, Robertson, Melissa, McMahon, Ellie, Ali, Farisha, Cowdrey, Keri-Anne, McArthur, Colin, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, O'Connor, Caroline, El-Khawas, Khaled, Hill, Dianne, Cattigan, Claire, Horton, Michelle, Trickey, Jemma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Sara, Treena, Nand, Kiran, Ramanan, Mahesh, Marella, Prashanti, Affleck, Julia, Simpson, Shannon, Ellem, Katrina, McKenna, Toni, Nourse, Mary, Leung, Kristine, Edmunds, Tash, McDonald, Bree, Mehrtens, Jan, Cross, Rosalba, Wong, Helen, Twardowski, Pawel, France, Dawn, Hanlon, Gabrielle, Barrett, Jonathan, Palermo, Annamaria, Pellicano, Susan, Eroglu, Ege, Bihari, Shailesh, Brown, Julia, Grear, Laura, Jin, Xia, French, Craig, Bates, Samantha, Marshall, Fiona, McEldrew, Rebecca, McCullough, James, Tallott, Mandy, Gough, Maimoonbe, Nalos, Marek, Younger, Laura, Krishnamurphy, Ravi, Trent, Louise, How, Janet, Stuart, Anne, Chadwick, Llesley, Bhadange, Neeraj, Tyler, Steven, Sosnowski, Kellie, Morrison, Lynette, Sutton, Joanne, Soar, Natalie, Lee, David, Doyle, Marina, Jongebloed, Katherine, Finnis, Mackenzie, Wilson, Jane, Williams, Tony, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Habraken, Hannah, Browne, Alex, Koelle, Jette, McNab, Charlotte, Masters, Kristy, Gresham, Rebecca, Lowrey, Julie, Whitehead, Christina, Liang, Janet, Harward, Meg, Jones, Cassie, Peake, Sandra, Williams, Tricia, Kurenda, Catherine, Tabah, Alexis, Duroux, Maree, Warhurst, Timothy, Ratcliffe, Megan, Pollock, Hamish, Baker, Stuart, Sonawane, Ravikiran, O'Connor, Stephanie, Brown, Nerissa, Glasby, Kathleen, Rivett, Justine, Campbell, Lewis, Tabuzo, Vera, Smyth, Kirsty, Bass, Frances, O'Connor, Anne, Leonard, Anton, Waterson, Sharon, Coles, Jennifer, Buhr, Heidi, Newman, Duncan, Boorawong, Piyaporn, Bregolin, Vanessa, Yun, Ji-Hyun, Anstey, Matthew, Rock, Lara, Endemann, Anthadene, Lo, Wei, Ferrier, Janet, Reynolds, Claire, Santamaria, John, Holmes, Jennifer, Beca, John, Sherring, Claire, Garrett, Peter, Murray, Lauren, Brailsford, Jane, Browne, Troy, Goodson, Jennifer, Udy, Andrew, Young, Meredith, Board, Jasmin, McCracken, Phoebe, Martin, Emma-Leah, Martynoga, Robert, Butler, Amelia, Trask, Kara, Olatunji, Shaanti, Cruz, Rhoze Sol, Cruz, Raulle Sol, Navarra, Leanlove, Delaney, Kirsha, Lesona, Eden, Young, Chelsea, Spring, Amelia, Aguilar, April, Young, Paul, Law, Erin, Anstey, Matthew H., Bhonagiri, Deepak, Hammond, Naomi E., and McGain, Forbes
- Published
- 2023
- Full Text
- View/download PDF
6. Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
- Author
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Kjær, Maj Brit Nørregaard, primary, Meyhoff, Tine S., additional, Sivapalan, Praleene, additional, Granholm, Andrers, additional, Hjortrup, Peter B., additional, Madsen, Martin B., additional, Hylander, Morten H., additional, Egerod, Ingrid, additional, Wetterslev, Jørn, additional, Lange, Theis, additional, Cronhjort, Maria, additional, Laake, Jon H., additional, Jakob, Stephan M., additional, Nalos, Marek, additional, Ostermann, Marlies, additional, Gould, Doug, additional, Cecconi, Maurizio, additional, Malbrain, Manu L.N.G., additional, Ahlstedt, Christian, additional, Kiel, Louise B., additional, Bestle, Morten H., additional, Nebrich, Lars, additional, Hildebrandt, Thomas, additional, Russell, Lene, additional, Vang, Marianne, additional, Rasmussen, Michael L., additional, Sølling, Christioffer, additional, Brøchner, Anne C., additional, Krag, Mette, additional, and Perner, Anders, additional
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- 2024
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7. How often are infusion sets for central venous catheters changed in Australian and New Zealand Intensive Care Units? A point prevalence survey
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Anstey, Matthew H., primary, Maxwell, Nicky, additional, Rickard, Claire M., additional, Hammond, Naomi E., additional, Knowles, Serena, additional, McGain, Forbes, additional, Hammond, Naomi, additional, Freeman-Sanderson, Amy, additional, Ganu, Subodh, additional, Howe, Belinda, additional, Litton, Ed, additional, Mackle, Diane, additional, Saxena, Manoj, additional, Seppelt, Ian, additional, Towns, Miriam, additional, Yarad, Elizabeth, additional, Gao, Annie, additional, Li, Yang, additional, Myburgh, John, additional, Nangla, Conrad, additional, Butt, Fatima, additional, Duke, Graeme, additional, Hunter, Stephanie, additional, Evans, Julie, additional, Parker, Dianne, additional, Loughnan, Clare, additional, Thomas, Blessy, additional, Gilder, Eileen, additional, Robertson, Melissa, additional, McMahon, Ellie, additional, Ali, Farisha, additional, Cowdrey, Keri-Anne, additional, McArthur, Colin, additional, Chen, Yan, additional, Simmonds, Catherine, additional, McConnochie, Rachael, additional, O'Connor, Caroline, additional, El-Khawas, Khaled, additional, Hill, Dianne, additional, Cattigan, Claire, additional, Horton, Michelle, additional, Trickey, Jemma, additional, Knott, Cameron, additional, Smith, Julie, additional, Boschert, Catherine, additional, Sara, Treena, additional, Nand, Kiran, additional, Ramanan, Mahesh, additional, Marella, Prashanti, additional, Affleck, Julia, additional, Simpson, Shannon, additional, Ellem, Katrina, additional, McKenna, Toni, additional, Nourse, Mary, additional, Leung, Kristine, additional, Edmunds, Tash, additional, McDonald, Bree, additional, Mehrtens, Jan, additional, Cross, Rosalba, additional, Wong, Helen, additional, Twardowski, Pawel, additional, France, Dawn, additional, Hanlon, Gabrielle, additional, Barrett, Jonathan, additional, Palermo, Annamaria, additional, Pellicano, Susan, additional, Eroglu, Ege, additional, Bihari, Shailesh, additional, Brown, Julia, additional, Grear, Laura, additional, Jin, Xia, additional, French, Craig, additional, Bates, Samantha, additional, Marshall, Fiona, additional, McEldrew, Rebecca, additional, McCullough, James, additional, Tallott, Mandy, additional, Gough, Maimoonbe, additional, Nalos, Marek, additional, Younger, Laura, additional, Krishnamurphy, Ravi, additional, Trent, Louise, additional, How, Janet, additional, Stuart, Anne, additional, Chadwick, Llesley, additional, Bhadange, Neeraj, additional, Tyler, Steven, additional, Sosnowski, Kellie, additional, Morrison, Lynette, additional, Sutton, Joanne, additional, Soar, Natalie, additional, Lee, David, additional, Doyle, Marina, additional, Jongebloed, Katherine, additional, Finnis, Mackenzie, additional, Wilson, Jane, additional, Williams, Tony, additional, Song, Rima, additional, Lai, Vivian, additional, Girijadevi, Dinu, additional, Habraken, Hannah, additional, Browne, Alex, additional, Koelle, Jette, additional, McNab, Charlotte, additional, Masters, Kristy, additional, Gresham, Rebecca, additional, Lowrey, Julie, additional, Whitehead, Christina, additional, Liang, Janet, additional, Harward, Meg, additional, Jones, Cassie, additional, Peake, Sandra, additional, Williams, Tricia, additional, Kurenda, Catherine, additional, Tabah, Alexis, additional, Duroux, Maree, additional, Warhurst, Timothy, additional, Ratcliffe, Megan, additional, Pollock, Hamish, additional, Baker, Stuart, additional, Sonawane, Ravikiran, additional, O'Connor, Stephanie, additional, Brown, Nerissa, additional, Glasby, Kathleen, additional, Rivett, Justine, additional, Campbell, Lewis, additional, Tabuzo, Vera, additional, Smyth, Kirsty, additional, Bass, Frances, additional, O'Connor, Anne, additional, Leonard, Anton, additional, Waterson, Sharon, additional, Coles, Jennifer, additional, Buhr, Heidi, additional, Newman, Duncan, additional, Boorawong, Piyaporn, additional, Bregolin, Vanessa, additional, Yun, Ji-Hyun, additional, Anstey, Matthew, additional, Rock, Lara, additional, Endemann, Anthadene, additional, Lo, Wei, additional, Ferrier, Janet, additional, Reynolds, Claire, additional, Santamaria, John, additional, Holmes, Jennifer, additional, Beca, John, additional, Sherring, Claire, additional, Garrett, Peter, additional, Murray, Lauren, additional, Brailsford, Jane, additional, Browne, Troy, additional, Goodson, Jennifer, additional, Udy, Andrew, additional, Young, Meredith, additional, Board, Jasmin, additional, McCracken, Phoebe, additional, Martin, Emma-Leah, additional, Martynoga, Robert, additional, Butler, Amelia, additional, Trask, Kara, additional, Olatunji, Shaanti, additional, Cruz, Rhoze Sol, additional, Cruz, Raulle Sol, additional, Navarra, Leanlove, additional, Delaney, Kirsha, additional, Lesona, Eden, additional, Young, Chelsea, additional, Spring, Amelia, additional, Aguilar, April, additional, Young, Paul, additional, and Law, Erin, additional
- Published
- 2024
- Full Text
- View/download PDF
8. Effects of IV fluid restriction according to site‐specific intensity of standard fluid treatment—protocol.
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Sivapalan, Praleene, Kaas‐Hansen, Benjamin Skov, Meyhoff, Tine Sylvest, Hjortrup, Peter Buhl, Kjær, Maj‐Brit N., Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L. N. G., Møller, Morten Hylander, Perner, Anders, and Granholm, Anders
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MACHINE learning ,BOOSTING algorithms ,SEPTIC shock ,FLUID therapy ,SHOCK therapy - Abstract
Background: Variation in usual practice in fluid trials assessing lower versus higher volumes may affect overall comparisons. To address this, we will evaluate the effects of heterogeneity in treatment intensity in the Conservative versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care trial. This will reflect the effects of differences in site‐specific intensities of standard fluid treatment due to local practice preferences while considering participant characteristics. Methods: We will assess the effects of heterogeneity in treatment intensity across one primary (all‐cause mortality) and three secondary outcomes (serious adverse events or reactions, days alive without life support and days alive out of hospital) after 90 days. We will classify sites based on the site‐specific intensity of standard fluid treatment, defined as the mean differences in observed versus predicted intravenous fluid volumes in the first 24 h in the standard‐fluid group while accounting for differences in participant characteristics. Predictions will be made using a machine learning model including 22 baseline predictors using the extreme gradient boosting algorithm. Subsequently, sites will be grouped into fluid treatment intensity subgroups containing at least 100 participants each. Subgroups differences will be assessed using hierarchical Bayesian regression models with weakly informative priors. We will present the full posterior distributions of relative (risk ratios and ratios of means) and absolute differences (risk differences and mean differences) in each subgroup. Discussion: This study will provide data on the effects of heterogeneity in treatment intensity while accounting for patient characteristics in critically ill adult patients with septic shock. Registrations: The European Clinical Trials Database (EudraCT): 2018‐000404‐42, ClinicalTrials. gov: NCT03668236. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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9. Albumin use in patients with septic shock—Post-hoc analyses of an international randomised fluid trial
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Meyhoff, Tine Sylvest, Granholm, Anders, Hjortrup, Peter Buhl, Sivapalan, Praleene, Lange, Theis, Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L.N.G., Møller, Morten Hylander, Perner, Anders, Meyhoff, Tine Sylvest, Granholm, Anders, Hjortrup, Peter Buhl, Sivapalan, Praleene, Lange, Theis, Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L.N.G., Møller, Morten Hylander, and Perner, Anders
- Abstract
Background Albumin administration is suggested in patients with sepsis and septic shock who have received large volumes of crystalloids. Given lack of firm evidence, clinical practice variation may exist. To address this, we investigated if patient characteristics or trial site were associated with albumin use in septic shock. Methods We conducted a post-hoc study of the CLASSIC international, randomised clinical trial of fluid volumes in septic shock. Associations between selected baseline variables and trial site with albumin use during ICU stay were assessed in Cox models considering death, ICU discharge, and loss-to-follow-up as competing events. Baseline variables were first assessed individually, adjusted for treatment allocation (restrictive vs. standard IV fluid), and then adjusted for allocation and the other baseline variables. Site was assessed in a model adjusted for allocation and baseline variables. Results We analysed 1541 of 1554 patients randomised in CLASSIC (99.2%). During ICU stay, 36.3% of patients in the restrictive-fluid group and 52.6% in the standard-fluid group received albumin. Gastrointestinal focus of infection and higher doses of norepinephrine were most strongly associated with albumin use (subgroup with highest quartile of norepinephrine doses, hazard ratio (HR) 2.58, 95% CI 1.89 to 3.53). HRs for associations between site and albumin use ranged from 0.11 (95% CI 0.05 to 0.26) to 1.70 (95% CI 1.06 to 2.74); test for overall effect of site: p < .001. Conclusions In adults with septic shock, gastrointestinal focus of infection and higher doses of norepinephrine at baseline were associated with albumin use, which also varied substantially between sites., Background: Albumin administration is suggested in patients with sepsis and septic shock who have received large volumes of crystalloids. Given lack of firm evidence, clinical practice variation may exist. To address this, we investigated if patient characteristics or trial site were associated with albumin use in septic shock. Methods: We conducted a post-hoc study of the CLASSIC international, randomised clinical trial of fluid volumes in septic shock. Associations between selected baseline variables and trial site with albumin use during ICU stay were assessed in Cox models considering death, ICU discharge, and loss-to-follow-up as competing events. Baseline variables were first assessed individually, adjusted for treatment allocation (restrictive vs. standard IV fluid), and then adjusted for allocation and the other baseline variables. Site was assessed in a model adjusted for allocation and baseline variables. Results: We analysed 1541 of 1554 patients randomised in CLASSIC (99.2%). During ICU stay, 36.3% of patients in the restrictive-fluid group and 52.6% in the standard-fluid group received albumin. Gastrointestinal focus of infection and higher doses of norepinephrine were most strongly associated with albumin use (subgroup with highest quartile of norepinephrine doses, hazard ratio (HR) 2.58, 95% CI 1.89 to 3.53). HRs for associations between site and albumin use ranged from 0.11 (95% CI 0.05 to 0.26) to 1.70 (95% CI 1.06 to 2.74); test for overall effect of site: p <.001. Conclusions: In adults with septic shock, gastrointestinal focus of infection and higher doses of norepinephrine at baseline were associated with albumin use, which also varied substantially between sites.
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- 2024
10. Restrictive versus standard IV fluid therapy in adult ICU patients with septic shock—Bayesian analyses of the CLASSIC trial
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Sivapalan, Praleene, Meyhoff, Tine Sylvest, Hjortrup, Peter Buhl, Lange, Theis, Kaas-Hansen, Benjamin Skov, Kjær, Maj Brit N., Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L.N.G., Møller, Morten Hylander, Perner, Anders, Granholm, Anders, Sivapalan, Praleene, Meyhoff, Tine Sylvest, Hjortrup, Peter Buhl, Lange, Theis, Kaas-Hansen, Benjamin Skov, Kjær, Maj Brit N., Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L.N.G., Møller, Morten Hylander, Perner, Anders, and Granholm, Anders
- Abstract
Background The CLASSIC trial assessed the effects of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock. This pre-planned study provides a probabilistic interpretation and evaluates heterogeneity in treatment effects (HTE). Methods We analysed mortality, serious adverse events (SAEs), serious adverse reactions (SARs) and days alive without life-support within 90 days using Bayesian models with weakly informative priors. HTE on mortality was assessed according to five baseline variables: disease severity, vasopressor dose, lactate levels, creatinine values and IV fluid volumes given before randomisation. Results The absolute difference in mortality was 0.2%-points (95% credible interval: −5.0 to 5.4; 47% posterior probability of benefit [risk difference <0.0%-points]) with restrictive IV fluid. The posterior probabilities of benefits with restrictive IV fluid were 72% for SAEs, 52% for SARs and 61% for days alive without life-support. The posterior probabilities of no clinically important differences (absolute risk difference ≤2%-points) between the groups were 56% for mortality, 49% for SAEs, 90% for SARs and 38% for days alive without life-support. There was 97% probability of HTE for previous IV fluid volumes analysed continuously, that is, potentially relatively lower mortality of restrictive IV fluids with higher previous IV fluids. No substantial evidence of HTE was found in the other analyses. Conclusion We could not rule out clinically important effects of restrictive IV fluid therapy on mortality, SAEs or days alive without life-support, but substantial effects on SARs were unlikely. IV fluids given before randomisation might interact with IV fluid strategy., Background: The CLASSIC trial assessed the effects of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock. This pre-planned study provides a probabilistic interpretation and evaluates heterogeneity in treatment effects (HTE). Methods: We analysed mortality, serious adverse events (SAEs), serious adverse reactions (SARs) and days alive without life-support within 90 days using Bayesian models with weakly informative priors. HTE on mortality was assessed according to five baseline variables: disease severity, vasopressor dose, lactate levels, creatinine values and IV fluid volumes given before randomisation. Results: The absolute difference in mortality was 0.2%-points (95% credible interval: −5.0 to 5.4; 47% posterior probability of benefit [risk difference <0.0%-points]) with restrictive IV fluid. The posterior probabilities of benefits with restrictive IV fluid were 72% for SAEs, 52% for SARs and 61% for days alive without life-support. The posterior probabilities of no clinically important differences (absolute risk difference ≤2%-points) between the groups were 56% for mortality, 49% for SAEs, 90% for SARs and 38% for days alive without life-support. There was 97% probability of HTE for previous IV fluid volumes analysed continuously, that is, potentially relatively lower mortality of restrictive IV fluids with higher previous IV fluids. No substantial evidence of HTE was found in the other analyses. Conclusion: We could not rule out clinically important effects of restrictive IV fluid therapy on mortality, SAEs or days alive without life-support, but substantial effects on SARs were unlikely. IV fluids given before randomisation might interact with IV fluid strategy.
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- 2024
11. Blood transcriptome analysis of patients with uncomplicated bacterial infection and sepsis
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Herwanto, Velma, Tang, Benjamin, Wang, Ya, Shojaei, Maryam, Nalos, Marek, Shetty, Amith, Lai, Kevin, McLean, Anthony S., and Schughart, Klaus
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- 2021
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12. Lactate – from villain to guardian
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Nalos, Marek, primary
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- 2023
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13. Implementation and Evaluation of a 24/7 eICU (Enhanced ICU) Model of Care in Regional and Rural NSW ICUs
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Bhonagiri, Deepak, primary, Hillman, Ken, additional, Lakshmanan, Ramanthan, additional, Shah, Umesh, additional, Harrison, Reema, additional, Ali, Irshad, additional, Nalos, Marek, additional, Sharma, Anurag, additional, parr, michael, additional, Lombardo, Lein, additional, pervez-Iqbal, Maha, additional, Singh, Florence, additional, Descaller, Joseph, additional, Featon, Karen, additional, Jones, Peta, additional, Varghese, Sobha, additional, Pulletz, Mark, additional, Gray, Nicole, additional, Hangar, Gail, additional, chen, Jack, additional, and Andersen, Janice, additional
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- 2023
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14. The comparative effects of 3% saline and 0.5M sodium lactate on cardiac function: a randomised, crossover study in volunteers
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Nalos, Marek, Kholodniak, Euguenia, Smith, Louise, Orde, Sam, Ting, Iris, Slama, Michel, Seppelt, Ian, McLean, Anthony S., and Huang, Stephen
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- 2018
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15. Bedside lung ultrasound in the care of the critically ill
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Rudas, Mate, Orde, Sam, and Nalos, Marek
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- 2017
16. The Computational Acid–Base Chemistry of Hepatic Ketoacidosis
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Torrens, Samuel L., primary, Robergs, Robert A., additional, Curry, Steven C., additional, and Nalos, Marek, additional
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- 2023
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17. Albumin administration in septic shock—Protocol for post‐hoc analyses of data from a multicentre RCT
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Meyhoff, Tine Sylvest, primary, Granholm, Anders, additional, Hjortrup, Peter Buhl, additional, Sivapalan, Praleene, additional, Lange, Theis, additional, Laake, Jon Henrik, additional, Cronhjort, Maria, additional, Jakob, Stephan M., additional, Cecconi, Maurizio, additional, Nalos, Marek, additional, Ostermann, Marlies, additional, Malbrain, Manu L. N. G., additional, Møller, Morten Hylander, additional, and Perner, Anders, additional
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- 2023
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18. Correction to: The association between premorbid beta blocker exposure and mortality in sepsis—a systematic review
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Tan, Kaiquan, Harazim, Martin, Tang, Benjamin, Mclean, Anthony, and Nalos, Marek
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- 2020
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19. Albumin administration in septic shock-Protocol for post-hoc analyses of data from a multicentre RCT
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Meyhoff, Tine Sylvest, Granholm, Anders, Hjortrup, Peter Buhl, Sivapalan, Praleene, Lange, Theis, Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M, Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L N G, Møller, Morten Hylander, and Perner, Anders
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Anesthesiology and Pain Medicine ,610 Medicine & health ,General Medicine - Abstract
BACKGROUND Intravenous (IV) albumin is suggested for patients with septic shock who have received large amounts of IV crystalloids; a conditional recommendation based on moderate certainty of evidence. Clinical variation in the administration of IV albumin in septic shock may exist according to patient characteristics and location. METHODS This is a protocol and statistical analysis plan for a post-hoc secondary study of the Conservative versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) RCT of 1554 adult ICU patients with septic shock. We will assess if specific baseline characteristics or trial site are associated with the administration of IV albumin during ICU stay using Cox models with competing events. All models will be adjusted for the treatment allocation in CLASSIC (restrictive vs. standard IV fluid), and all analyses will consider competing events (death, ICU discharge and loss-to-follow-up). We will present results as hazard ratios with 95% confidence intervals and p-values for the associations of baseline characteristics or site with IV albumin administration. Between-group differences (interactions) will be assessed using p-values from likelihood ratio tests. All results will be considered exploratory only. DISCUSSION This secondary study of the CLASSIC RCT may yield important insight into potential practice variation in the administration of albumin in septic shock.
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- 2023
20. The use of echocardiographic indices in defining and assessing right ventricular systolic function in critical care research
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Huang, Stephen J., Nalos, Marek, Smith, Louise, Rajamani, Arvind, and McLean, Anthony S.
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Pulmonary embolism -- Diagnosis -- Care and treatment ,Echocardiography -- Methods ,Critically ill -- Care and treatment ,Acute respiratory distress syndrome -- Diagnosis -- Care and treatment ,Health care industry - Abstract
Purpose Many echocardiographic indices (or methods) for assessing right ventricular (RV) function are available, but each has its strengths and limitations. In some cases, there might be discordance between the indices. We conducted a systematic review to audit the echocardiographic RV assessments in critical care research to see if a consistent pattern existed. We specifically looked into the kind and number of RV indices used, and how RV dysfunction was defined in each study. Methods Studies conducted in critical care settings and reported echocardiographic RV function indices from 1997 to 2017 were searched systematically from three databases. Non-adult studies, case reports, reviews and secondary studies were excluded. These studies' characteristics and RV indices reported were summarized. Results Out of 495 non-duplicated publications found, 81 studies were included in our systematic review. There has been an increasing trend of studying RV function by echocardiography since 2001, and most were conducted in ICU. Thirty-one studies use a single index, mostly TAPSE, to define RV dysfunction; 33 used composite indices and the combinations varied between studies. Seventeen studies did not define RV dysfunction. For those using composite indices, many did not explain their choices. Conclusions TAPSE seemed to be the most popular index in the last 2-3 years. Many studies used combinations of indices but, apart from cor pulmonale, we could not find a consistent pattern of RV assessment and definition of RV dysfunction amongst these studies., Author(s): Stephen J. Huang [sup.1] , Marek Nalos [sup.1] , Louise Smith [sup.2] , Arvind Rajamani [sup.1] , Anthony S. McLean [sup.1] Author Affiliations: (1) 0000 0004 1936 834X, grid.1013.3, [...]
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- 2018
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21. Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
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Kjær, Maj-Brit Nørregaard, primary, Meyhoff, Tine Sylvest, additional, Sivapalan, Praleene, additional, Granholm, Anders, additional, Hjortrup, Peter Buhl, additional, Madsen, Martin Bruun, additional, Møller, Morten Hylander, additional, Egerod, Ingrid, additional, Wetterslev, Jørn, additional, Lange, Theis, additional, Cronhjort, Maria, additional, Laake, Jon Henrik, additional, Jakob, Stephan M., additional, Nalos, Marek, additional, Ostermann, Marlies, additional, Gould, Doug, additional, Cecconi, Maurizio, additional, Malbrain, Manu L. N. G., additional, Ahlstedt, Christian, additional, Kiel, Louise Bendix, additional, Bestle, Morten H, additional, Nebrich, Lars, additional, Hildebrandt, Thomas, additional, Russell, Lene, additional, Vang, Marianne, additional, Lindhart, Michael, additional, Søllling, Christoffer, additional, Brøchner, Anne Craveiro, additional, Krag, Mette, additional, Pfortmueller, Carmen, additional, Kriz, Miroslav, additional, Siegemund, Martin, additional, Albano, Giovanni, additional, Aagaard, Søren Rosborg, additional, Bundgaard, Helle, additional, Crone, Vera, additional, Wichmann, Sine, additional, Johnstad, Bror, additional, Martin, Yvonne Karin, additional, Seidel, Philipp, additional, Mårtensson, Johan, additional, Hollenberg, Jacob, additional, Witstrand, Mats, additional, Donati, Abele, additional, Barbara, Enrico, additional, Karvunidis, Thomas, additional, Hollinger, Alexa, additional, Carsetti, Andrea, additional, Lumlertgul, Nuttha, additional, Joelsson-Alm, Eva, additional, Lambiris, Nikolas, additional, Aslam, Tayyba Naz, additional, Friberg, Fredrik Femtehjell, additional, Vesterlund, Gitte Kingo, additional, Mortensen, Camilla Bekker, additional, Vestergaard, Stine Rom, additional, Caspersen, Sidsel Fjordbak, additional, Jensen, Diana Bertelsen, additional, Brorup, Morten, additional, Rasmussen, Bodil Steen, additional, and Perner, Anders, additional
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- 2023
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22. Blood urea nitrogen - independent marker of mortality in sepsis
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Harazim, Martin, primary, Tan, Kaiquan, additional, Nalos, Marek, additional, and Matejovic, Martin, additional
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- 2023
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23. Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
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Kjær, Maj Brit Nørregaard, Meyhoff, Tine Sylvest, Sivapalan, Praleene, Granholm, Anders, Hjortrup, Peter Buhl, Madsen, Martin Bruun, Møller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jørn, Lange, Theis, Cronhjort, Maria, Laake, Jon Henrik, Jakob, Stephan M., Nalos, Marek, Ostermann, Marlies, Gould, Doug, Cecconi, Maurizio, Malbrain, Manu L.N.G., Ahlstedt, Christian, Kiel, Louise Bendix, Bestle, Morten H., Nebrich, Lars, Hildebrandt, Thomas, Russell, Lene, Vang, Marianne, Rasmussen, Michael Lindhart, Sølling, Christoffer, Brøchner, Anne Craveiro, Krag, Mette, Pfortmueller, Carmen, Kriz, Miroslav, Siegemund, Martin, Albano, Giovanni, Aagaard, Søren Rosborg, Bundgaard, Helle, Crone, Vera, Wichmann, Sine, Johnstad, Bror, Martin, Yvonne Karin, Seidel, Philipp, Mårtensson, Johan, Hollenberg, Jacob, Wistrand, Mats, Donati, Abele, Barbara, Enrico, Karvunidis, Thomas, Hollinger, Alexa, Carsetti, Andrea, Lumlertgul, Nuttha, Joelsson-Alm, Eva, Lambiris, Nikolas, Aslam, Tayyba Naz, Friberg, Fredrik Femtehjell, Vesterlund, Gitte Kingo, Mortensen, Camilla Bekker, Vestergaard, Stine Rom, Caspersen, Sidsel Fjordbak, Jensen, Diana Bertelsen, Borup, Morten, Rasmussen, Bodil Steen, Perner, Anders, Kjær, Maj Brit Nørregaard, Meyhoff, Tine Sylvest, Sivapalan, Praleene, Granholm, Anders, Hjortrup, Peter Buhl, Madsen, Martin Bruun, Møller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jørn, Lange, Theis, Cronhjort, Maria, Laake, Jon Henrik, Jakob, Stephan M., Nalos, Marek, Ostermann, Marlies, Gould, Doug, Cecconi, Maurizio, Malbrain, Manu L.N.G., Ahlstedt, Christian, Kiel, Louise Bendix, Bestle, Morten H., Nebrich, Lars, Hildebrandt, Thomas, Russell, Lene, Vang, Marianne, Rasmussen, Michael Lindhart, Sølling, Christoffer, Brøchner, Anne Craveiro, Krag, Mette, Pfortmueller, Carmen, Kriz, Miroslav, Siegemund, Martin, Albano, Giovanni, Aagaard, Søren Rosborg, Bundgaard, Helle, Crone, Vera, Wichmann, Sine, Johnstad, Bror, Martin, Yvonne Karin, Seidel, Philipp, Mårtensson, Johan, Hollenberg, Jacob, Wistrand, Mats, Donati, Abele, Barbara, Enrico, Karvunidis, Thomas, Hollinger, Alexa, Carsetti, Andrea, Lumlertgul, Nuttha, Joelsson-Alm, Eva, Lambiris, Nikolas, Aslam, Tayyba Naz, Friberg, Fredrik Femtehjell, Vesterlund, Gitte Kingo, Mortensen, Camilla Bekker, Vestergaard, Stine Rom, Caspersen, Sidsel Fjordbak, Jensen, Diana Bertelsen, Borup, Morten, Rasmussen, Bodil Steen, and Perner, Anders
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Purpose: To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial. Methods: We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function. Results: Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385/746 (51.3%) in the restrictive-fluid group versus 383/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) − 4.8 to 7.8]. Mean differences were 0.00 (99% CI − 0.06 to 0.05) for EQ-5D-5L index values, − 0.65 for EQ VAS (− 5.40 to 4.08), and − 0.14 for Mini MoCA (− 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups. Conclusions: Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out.
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- 2023
24. IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study
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Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Teo, Siok Min, Rodrigues Rossi, Gustavo, McCulloch, Timothy R., Nalos, Marek, Raei, Maedeh, Razavi, Alireza, Ghasemian, Roya, Gheibi, Mobina, Roozbeh, Fatemeh, Sly, Peter D., Spann, Kirsten M., Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Kuniyoshi, Carmen Lúcia, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, Noronha, Lucia de, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin, Gogna, Rajan, Madan, Esha, Alizadeh-Navaei, Reza, Lamperti, Liliana, Zuñiga, Felipe, Nova-Lamperti, Estefania, Labarca, Gonzalo, Knippenberg, Ben, Herwanto, Velma, Wang, Ya, Phu, Amy, Chew, Tracy, Kwan, Timothy, Kim, Karan, Teoh, Sally, Pelaia, Tiana M., Kuan, Win Sen, Jee, Yvette, Iredell, Jon, O’Byrne, Ken, Fraser, John F., Davis, Melissa J., Belz, Gabrielle T., Warkiani, Majid E., Gallo, Carlos Salomon, Souza-Fonseca-Guimaraes, Fernando, Nguyen, Quan, Mclean, Anthony, Kulasinghe, Arutha, Short, Kirsty R., Tang, Benjamin, Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Teo, Siok Min, Rodrigues Rossi, Gustavo, McCulloch, Timothy R., Nalos, Marek, Raei, Maedeh, Razavi, Alireza, Ghasemian, Roya, Gheibi, Mobina, Roozbeh, Fatemeh, Sly, Peter D., Spann, Kirsten M., Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Kuniyoshi, Carmen Lúcia, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, Noronha, Lucia de, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin, Gogna, Rajan, Madan, Esha, Alizadeh-Navaei, Reza, Lamperti, Liliana, Zuñiga, Felipe, Nova-Lamperti, Estefania, Labarca, Gonzalo, Knippenberg, Ben, Herwanto, Velma, Wang, Ya, Phu, Amy, Chew, Tracy, Kwan, Timothy, Kim, Karan, Teoh, Sally, Pelaia, Tiana M., Kuan, Win Sen, Jee, Yvette, Iredell, Jon, O’Byrne, Ken, Fraser, John F., Davis, Melissa J., Belz, Gabrielle T., Warkiani, Majid E., Gallo, Carlos Salomon, Souza-Fonseca-Guimaraes, Fernando, Nguyen, Quan, Mclean, Anthony, Kulasinghe, Arutha, Short, Kirsty R., and Tang, Benjamin
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Purpose: Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, there is no consensus on the best diagnostic approach to predict outcomes in infected patients. Moreover, it is not clear whether such tools would apply to other potentially pandemic pathogens and therefore of use as stockpile for future pandemic preparedness. Methods: We conducted a multi-cohort observational study to investigate the biology and the prognostic role of interferon alpha-inducible protein 27 (IFI27) in COVID-19 patients. Results: We show that IFI27 is expressed in the respiratory tract of COVID-19 patients and elevated IFI27 expression in the lower respiratory tract is associated with the presence of a high viral load. We further demonstrate that the systemic host response, as measured by blood IFI27 expression, is associated with COVID-19 infection. For clinical outcome prediction (e.g., respiratory failure), IFI27 expression displays a high sensitivity (0.95) and specificity (0.83), outperforming other known predictors of COVID-19 outcomes. Furthermore, IFI27 is upregulated in the blood of infected patients in response to other respiratory viruses. For example, in the pandemic H1N1/09 influenza virus infection, IFI27-like genes were highly upregulated in the blood samples of severely infected patients. Conclusion: These data suggest that prognostic biomarkers targeting the family of IFI27 genes could potentially supplement conventional diagnostic tools in future virus pandemics, independent of whether such pandemics are caused by a coronavirus, an influenza virus or another as yet-to-be discovered respiratory virus.
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- 2023
25. Bedside lung ultrasound, mobile radiography and physical examination: a comparative analysis of diagnostic tools in the critically ill
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Inglis, Andrew J., Nalos, Marek, Sue, Kwan-Hing, Hruby, Jan, Campbell, Daniel M., Braham, Rachel M., and Orde, Sam R.
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- 2016
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26. The association between premorbid beta blocker exposure and mortality in sepsis—a systematic review
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Tan, Kaiquan, Harazim, Martin, Tang, Benjamin, Mclean, Anthony, and Nalos, Marek
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- 2019
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27. IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study
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Shojaei, Maryam, primary, Shamshirian, Amir, additional, Monkman, James, additional, Grice, Laura, additional, Tran, Minh, additional, Tan, Chin Wee, additional, Teo, Siok Min, additional, Rodrigues Rossi, Gustavo, additional, McCulloch, Timothy R., additional, Nalos, Marek, additional, Raei, Maedeh, additional, Razavi, Alireza, additional, Ghasemian, Roya, additional, Gheibi, Mobina, additional, Roozbeh, Fatemeh, additional, Sly, Peter D., additional, Spann, Kirsten M., additional, Chew, Keng Yih, additional, Zhu, Yanshan, additional, Xia, Yao, additional, Wells, Timothy J., additional, Senegaglia, Alexandra Cristina, additional, Kuniyoshi, Carmen Lúcia, additional, Franck, Claudio Luciano, additional, dos Santos, Anna Flavia Ribeiro, additional, Noronha, Lucia de, additional, Motamen, Sepideh, additional, Valadan, Reza, additional, Amjadi, Omolbanin, additional, Gogna, Rajan, additional, Madan, Esha, additional, Alizadeh-Navaei, Reza, additional, Lamperti, Liliana, additional, Zuñiga, Felipe, additional, Nova-Lamperti, Estefania, additional, Labarca, Gonzalo, additional, Knippenberg, Ben, additional, Herwanto, Velma, additional, Wang, Ya, additional, Phu, Amy, additional, Chew, Tracy, additional, Kwan, Timothy, additional, Kim, Karan, additional, Teoh, Sally, additional, Pelaia, Tiana M., additional, Kuan, Win Sen, additional, Jee, Yvette, additional, Iredell, Jon, additional, O’Byrne, Ken, additional, Fraser, John F., additional, Davis, Melissa J., additional, Belz, Gabrielle T., additional, Warkiani, Majid E., additional, Gallo, Carlos Salomon, additional, Souza-Fonseca-Guimaraes, Fernando, additional, Nguyen, Quan, additional, Mclean, Anthony, additional, Kulasinghe, Arutha, additional, Short, Kirsty R., additional, and Tang, Benjamin, additional
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- 2023
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28. Transcriptional reprogramming of metabolic pathways in critically ill patients
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Nalos, Marek, Parnell, Grant, Robergs, Robert, Booth, David, McLean, Anthony S., and Tang, Benjamin M.
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- 2016
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29. Perioperative Nutrition
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Nalos, Marek, primary
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- 2022
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30. Moderate and Severe Acute Respiratory Distress Syndrome: Hemodynamic and Cardiac Effects of an Open Lung Strategy With Recruitment Maneuver Analyzed Using Echocardiography*
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Mercado, Pablo, Maizel, Julien, Kontar, Loay, Nalos, Marek, Huang, Stephen, Orde, Sam, McLean, Anthony, and Slama, Michel
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- 2018
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31. A novel sampling method to detect airborne influenza and other respiratory viruses in mechanically ventilated patients: a feasibility study
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Mitchell, Alicia B., Tang, Benjamin, Shojaei, Maryam, Barnes, Lachlan S., Nalos, Marek, Oliver, Brian G., and McLean, Anthony S.
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- 2018
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32. Restriction of Intravenous Fluid in ICU Patients with Septic Shock
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Meyhoff, Tine S., Hjortrup, Peter B., Wetterslev, Jørn, Sivapalan, Praleene, Laake, Jon H., Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu, Pettilä, Ville, Møller, Morten H., Kjær, Maj-Brit N., Lange, Theis, Overgaard-Steensen, Christian, Brand, Björn A., Winther-Olesen, Marie, White, Jonathan O., Quist, Lars, Westergaard, Bo, Jonsson, Andreas B., Hjortsø, Carl J.S., Meier, Nick, Jensen, Thomas S., Engstrøm, Janus, Nebrich, Lars, Andersen-Ranberg, Nina C., Jensen, Jacob V., Joseph, Neeliya A., Poulsen, Lone M., Herløv, Louise S., Sølling, Christoffer G., Pedersen, Susan K., Knudsen, Kurt K., Straarup, Therese S., Vang, Marianne L., Bundgaard, Helle, Rasmussen, B. S., Aagaard, S. R., Hildebrandt, Thomas, Russell, Lene, Bestle, Morten H., Schønemann-Lund, Martin, Brøchner, Anne C., Elvander, Claes F., Hoffmann, Søren K.L., Rasmussen, Michael L., Martin, Yvonne K., Friberg, Fredrik F., Seter, Herman, Aslam, Tayyba N., Ådnøy, Sigrid, Seidel, Philipp, Strand, Kristian, Johnstad, Bror, Joelsson-Alm, Eva, Christensen, Jens, Ahlstedt, Christian, Pfortmueller, Carmen A., Siegemund, Martin, Greco, Massimiliano, Raděj, Jaroslav, Kříž, Miroslav, Gould, Doug W., Rowan, Kathy M., Mouncey, Paul R., Perner, Anders, Siegumfeldt, Rine Moulvad, and Vestergaard, Stine Rom
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PROTOCOL ,Adult ,SEPSIS ,RESUSCITATION ,MORTALITY ,Critical Care/methods ,ADULTS ,General Medicine ,Intensive Care Units ,TRIALS ,MANAGEMENT ,Humans ,Administration, Intravenous ,610 Medicine & health ,Shock, Septic/mortality ,Fluid Therapy/adverse effects - Abstract
BACKGROUND: Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU).METHODS: In this international, randomized trial, we assigned patients with septic shock in the ICU who had received at least 1 liter of intravenous fluid to receive restricted intravenous fluid or standard intravenous fluid therapy; patients were included if the onset of shock had been within 12 hours before screening. The primary outcome was death from any cause within 90 days after randomization.RESULTS: We enrolled 1554 patients; 770 were assigned to the restrictive-fluid group and 784 to the standard-fluid group. Primary outcome data were available for 1545 patients (99.4%). In the ICU, the restrictive-fluid group received a median of 1798 ml of intravenous fluid (interquartile range, 500 to 4366); the standard-fluid group received a median of 3811 ml (interquartile range, 1861 to 6762). At 90 days, death had occurred in 323 of 764 patients (42.3%) in the restrictive-fluid group, as compared with 329 of 781 patients (42.1%) in the standard-fluid group (adjusted absolute difference, 0.1 percentage points; 95% confidence interval [CI], -4.7 to 4.9; P = 0.96). In the ICU, serious adverse events occurred at least once in 221 of 751 patients (29.4%) in the restrictive-fluid group and in 238 of 772 patients (30.8%) in the standard-fluid group (adjusted absolute difference, -1.7 percentage points; 99% CI, -7.7 to 4.3). At 90 days after randomization, the numbers of days alive without life support and days alive and out of the hospital were similar in the two groups.CONCLUSIONS: Among adult patients with septic shock in the ICU, intravenous fluid restriction did not result in fewer deaths at 90 days than standard intravenous fluid therapy. (Funded by the Novo Nordisk Foundation and others; CLASSIC ClinicalTrials.gov number, NCT03668236.).
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- 2022
33. Restriction of Intravenous Fluid in ICU Patients with Septic Shock
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Meyhoff, Tine S., primary, Hjortrup, Peter B., additional, Wetterslev, Jørn, additional, Sivapalan, Praleene, additional, Laake, Jon H., additional, Cronhjort, Maria, additional, Jakob, Stephan M., additional, Cecconi, Maurizio, additional, Nalos, Marek, additional, Ostermann, Marlies, additional, Malbrain, Manu, additional, Pettilä, Ville, additional, Møller, Morten H., additional, Kjær, Maj-Brit N., additional, Lange, Theis, additional, Overgaard-Steensen, Christian, additional, Brand, Björn A., additional, Winther-Olesen, Marie, additional, White, Jonathan O., additional, Quist, Lars, additional, Westergaard, Bo, additional, Jonsson, Andreas B., additional, Hjortsø, Carl J.S., additional, Meier, Nick, additional, Jensen, Thomas S., additional, Engstrøm, Janus, additional, Nebrich, Lars, additional, Andersen-Ranberg, Nina C., additional, Jensen, Jacob V., additional, Joseph, Neeliya A., additional, Poulsen, Lone M., additional, Herløv, Louise S., additional, Sølling, Christoffer G., additional, Pedersen, Susan K., additional, Knudsen, Kurt K., additional, Straarup, Therese S., additional, Vang, Marianne L., additional, Bundgaard, Helle, additional, Rasmussen, Bodil S., additional, Aagaard, Søren R., additional, Hildebrandt, Thomas, additional, Russell, Lene, additional, Bestle, Morten H., additional, Schønemann-Lund, Martin, additional, Brøchner, Anne C., additional, Elvander, Claes F., additional, Hoffmann, Søren K.L., additional, Rasmussen, Michael L., additional, Martin, Yvonne K., additional, Friberg, Fredrik F., additional, Seter, Herman, additional, Aslam, Tayyba N., additional, Ådnøy, Sigrid, additional, Seidel, Philipp, additional, Strand, Kristian, additional, Johnstad, Bror, additional, Joelsson-Alm, Eva, additional, Christensen, Jens, additional, Ahlstedt, Christian, additional, Pfortmueller, Carmen A., additional, Siegemund, Martin, additional, Greco, Massimiliano, additional, Raděj, Jaroslav, additional, Kříž, Miroslav, additional, Gould, Doug W., additional, Rowan, Kathy M., additional, Mouncey, Paul R., additional, and Perner, Anders, additional
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- 2022
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34. Feeding intolerance in critically ill patients with Covid-19
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Nalos, Marek, primary
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- 2022
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35. How much do we throw away in the intensive care unit? An observational point prevalence study of Australian and New Zealand ICUs
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Anstey, Matthew H., Trent, Louise, Bhonagiri, Deepak, Hammond, Naomi E., Knowles, Serena, McGain, Forbes, Hammond, Naomi, Knowles, Serena, Freeman-Sanderson, Amy, Ganu, Subodh, Howe, Belinda, Litton, Ed, Mackle, Diane, Saxena, Manoj, Seppelt, Ian, Towns, Miriam, Yarad, Elizabeth, Hammond, Knowles, Serena, Gao, Annie, Li, Yang, Myburgh, John, Seppelt, Ian, Nangla, Conrad, Butt, Fatima, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Gilder, Eileen, Robertson, Melissa, McMahon, Ellie, Ali, Farisha, Cowdrey, Keri-Anne, McArthur, Colin, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, O'Connor, Caroline, El-Khawas, Khaled, Hill, Dianne, Cattigan, Claire, Horton, Michelle, Trickey, Jemma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Sara, Treena, Nand, Kiran, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Ramanan, Mahesh, Marella, Prashanti, Affleck, Julia, Simpson, Shannon, Ellem, Katrina, McKenna, Toni, Nourse, Mary, Leung, Kristine, Edmunds, Tash, McDonald, Bree, Mehrtens, Jan, Cross, Rosalba, Wong, Helen, Twardowski, Pawel, France, Dawn, Hanlon, Gabrielle, Barrett, Jonathan, Palermo, Annamaria, Pellicano, Susan, Eroglu, Ege, Bihari, Shailesh, Brown, Julia, Grear, Laura, Jin, Xia, French, Craig, Bates, Samantha, Towns, Miriam, Marshall, Fiona, McEldrew, Rebecca, McCullough, James, Tallott, Mandy, Gough, Maimoonbe, Nalos, Marek, Younger, Laura, Krishnamurphy, Ravi, Trent, Louise, How, Janet, Stuart, Anne, Chadwick, Llesley, Bhadange, Neeraj, Tyler, Steven, Sosnowski, Kellie, Morrison, Lynette, Sutton, Joanne, Soar, Natalie, Lee, David, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Doyle, Marina, Jongebloed, Katherine, Finnis, Mackenzie, Wilson, Jane, Williams, Tony, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Habraken, Hannah, Browne, Alex, Koelle, Jette, McNab, Charlotte, Masters, Kristy, Gresham, Rebecca, Lowrey, Julie, Whitehead, Christina, Liang, Janet, Harward, Meg, Jones, Cassie, Peake, Sandra, Williams, Tricia, Kurenda, Catherine, Tabah, Alexis, Duroux, Maree, Warhurst, Timothy, Ratcliffe, Megan, Pollock, Hamish, Baker, Stuart, Sonawane, Ravikiran, O'Connor, Stephanie, Brown, Nerissa, Glasby, Kathleen, Rivett, Justine, Campbell, Lewis, Tabuzo, Vera, Smyth, Kirsty, Yarad, Elizabeth, Bass, Frances, Hammond, Naomi, O'Connor, Anne, Leonard, Anton, Waterson, Sharon, Coles, Jennifer, Buhr, Heidi, Newman, Duncan, Boorawong, Piyaporn, Bregolin, Vanessa, Yun, Ji-Hyun, Anstey, Matthew, Rock, Lara, Endemann, Anthadene, Lo, Wei, Ferrier, Janet, Palermo, Annamaria, Reynolds, Claire, Santamaria, John, Holmes, Jennifer, Beca, John, Sherring, Claire, Garrett, Peter, Murray, Lauren, Brailsford, Jane, French, Craig, Bates, Samantha, Towns, Miriam, Marshall, Fiona, McEldrew, Rebecca, Browne, Troy, Goodson, Jennifer, Udy, Andrew, Young, Meredith, Board, Jasmin, McCracken, Phoebe, Martin, Emma-Leah, Martynoga, Robert, Butler, Amelia, Trask, Kara, Olatunji, Shaanti, Cruz, Rhoze Sol, Cruz, Raulle Sol, Navarra, Leanlove, Delaney, Kirsha, Lesona, Eden, Young, Chelsea, Spring, Amelia, Aguilar, April, Young, Paul, and Law, Erin
- Abstract
During the current COVID pandemic, waste generation has been more evident with increased use of single use masks, gowns and other personal protective equipment. We aimed to understand the scale of waste generation, recycling rates and participation in Australian and New Zealand (ANZ) ICUs.
- Published
- 2023
- Full Text
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36. IFI27 transcription is an early predictor for COVID-19 outcomes; a multi-cohort observational study
- Author
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Shojaei, Maryam, primary, Shamshirian, Amir, additional, Monkman, James, additional, Grice, Laura, additional, Tran, Minh, additional, Tan, Chin Wee, additional, Rossi, Gustavo Rodrigues, additional, McCulloch, Timothy R., additional, Nalos, Marek, additional, Chew, Keng Yih, additional, Zhu, Yanshan, additional, Xia, Yao, additional, Wells, Timothy J., additional, Senegaglia, Alexandra Cristina, additional, Rebelatto, Carmen Lúcia Kuniyoshi, additional, Franck, Claudio Luciano, additional, dos Santos, Anna Flavia Ribeiro, additional, de Noronha, Lucia, additional, Motamen, Sepideh, additional, Valadan, Reza, additional, Amjadi, Omolbanin, additional, Gogna, Rajan, additional, Madan, Esha, additional, Alizadeh-Navaei, Reza, additional, Lamperti, Liliana, additional, Zuñiga, Felipe, additional, Nova-Lamperti, Estefania, additional, Labarca, Gonzalo, additional, Knippenberg, Ben, additional, Herwanto, Velma, additional, Wang, Ya, additional, Phu, Amy, additional, Chew, Tracy, additional, Kwan, Timothy, additional, Kim, Karan, additional, Teoh, Sally, additional, Pelaia, Tiana M, additional, Kuan, Win Sen, additional, Jee, Yvette, additional, Iredell, Jon, additional, O’Byrne, Ken, additional, Fraser, John F., additional, Davis, Melissa J., additional, Belz, Gabrielle, additional, Warkiani, Majid, additional, Gallo, Carlos Salomon, additional, Souza-Fonseca-Guimaraes, Fernando, additional, Nguyen, Quan, additional, Mclean, Anthony, additional, Kulasinghe, Arutha, additional, Short, Kirsty R., additional, and Tang, Benjamin, additional
- Published
- 2021
- Full Text
- View/download PDF
37. “Host tissue damage” signal ATP impairs IL-12 and IFNγ secretion in LPS stimulated whole human blood
- Author
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Nalos, Marek, Huang, Stephen, Sluyter, Ronald, Khan, Alamgir, Santner-Nanan, Brigitte, Nanan, Ralph, and McLean, Anthony S.
- Published
- 2008
- Full Text
- View/download PDF
38. Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes—The Beta-Blockers in European and Australian/American Septic Patients (BEAST) Study
- Author
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Tan, Kaiquan, primary, Harazim, Martin, additional, Simpson, Andrew, additional, Tan, Yi Chern, additional, Gunawan, Gunawan, additional, Robledo, Kristy P., additional, Whitehead, Christina, additional, Tang, Benjamin, additional, Mclean, Anthony, additional, and Nalos, Marek, additional
- Published
- 2021
- Full Text
- View/download PDF
39. Immunophenotyping of Peripheral Blood Mononuclear Cells in Septic Shock Patients With High-Dimensional Flow Cytometry Analysis Reveals Two Subgroups With Differential Responses to Immunostimulant Drugs
- Author
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Wang, Ya, primary, Gloss, Brian, additional, Tang, Benjamin, additional, Dervish, Suat, additional, Santner-Nanan, Brigitte, additional, Whitehead, Christina, additional, Masters, Kristy, additional, Skarratt, Kristen, additional, Teoh, Sally, additional, Schibeci, Stephen, additional, Fewings, Nicole, additional, Brignone, Chrystelle, additional, Triebel, Frederic, additional, Booth, David, additional, McLean, Anthony, additional, and Nalos, Marek, additional
- Published
- 2021
- Full Text
- View/download PDF
40. Additional file 1 of Pathway mapping of leukocyte transcriptome in influenza patients reveals distinct pathogenic mechanisms associated with progression to severe infection
- Author
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Zerbib, Yoann, Jenkins, Emily, Shojaei, Maryam, Meyers, Adrienne, Ho, John, T. Ball, Keynan, Yoav, Amarnath Pisipati, Aseem Kumar, Kumar, Anand, Nalos, Marek, Tang, Benjamin, Schughart, Klaus, and McLean, Anthony
- Abstract
Additional file 1: Figure S1. Principal component analysis. Figure S2. Number of differentially expressed genes and proportion of interferon-stimulated gene for the three comparisons. Figure S3. Boxplots of Interferon-stimulated genes-expression. Table S1. Top 10 pathways ranked by statistical significance - moderate influenza patients compared to healthy controls. Table S2. Top 10 pathways ranked by statistical significance - severe influenza patients compare to healthy controls. Table S3. Top 10 pathways ranked by statistical significance - severe influenza patients compare to moderate influenza patients. Table S4. Top 30 differentially expressed genes (ranked by expression levels) between moderate and severe infections. Table S5. a Top 20 most upregulated genes in both datasets. b Top 20 most downregulated genes in both datasets.
- Published
- 2020
- Full Text
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41. Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial
- Author
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Kjaer, Maj-Brit N., Meyhoff, Tine S., Madsen, Martin B., Hjortrup, Peter B., Moller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jorn, Lange, Theis, Cronhjort, Maria, Laake, Jon H., Jakob, Stephan M., Nalos, Marek, Pettila, Ville, van der Horst, Iwan C. C., Ostermann, Marlies, Mouncey, Paul, Cecconi, Maurizio, Ferrer, Ricard, Malbrain, Manu L. N. G., Ahlstedt, Christian, Hoffmann, Soren, Bestle, Morten H., Gyldensted, Louise, Nebrich, Lars, Russell, Lene, Vang, Marianne, Solling, Christoffer, Brochner, Anne C., Rasmussen, Bodil S., Perner, Anders, Kjaer, Maj-Brit N., Meyhoff, Tine S., Madsen, Martin B., Hjortrup, Peter B., Moller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jorn, Lange, Theis, Cronhjort, Maria, Laake, Jon H., Jakob, Stephan M., Nalos, Marek, Pettila, Ville, van der Horst, Iwan C. C., Ostermann, Marlies, Mouncey, Paul, Cecconi, Maurizio, Ferrer, Ricard, Malbrain, Manu L. N. G., Ahlstedt, Christian, Hoffmann, Soren, Bestle, Morten H., Gyldensted, Louise, Nebrich, Lars, Russell, Lene, Vang, Marianne, Solling, Christoffer, Brochner, Anne C., Rasmussen, Bodil S., and Perner, Anders
- Published
- 2020
42. Prospective validation study of prognostic biomarkers to predict adverse outcomes in patients with COVID-19: a study protocol
- Author
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Tang, Benjamin, primary, Shojaei, Maryam, additional, Wang, Ya, additional, Nalos, Marek, additional, Mclean, Anthony, additional, Afrasiabi, Ali, additional, Kwan, Tim N, additional, Kuan, Win Sen, additional, Zerbib, Yoann, additional, Herwanto, Velma, additional, Gunawan, Gunawan, additional, Bedognetti, Davide, additional, Zoppoli, Gabriele, additional, Ballestrero, Alberto, additional, Rinchai, Darawan, additional, Cremonesi, Paolo, additional, Bedognetti, Michele, additional, Matejovic, Martin, additional, Karvunidis, Thomas, additional, Macdonald, Stephen P J, additional, Cox, Amanda J, additional, West, Nicholas P, additional, Cripps, Allan William, additional, Schughart, Klaus, additional, Maria, Andrea de, additional, Chaussabel, Damien, additional, Iredell, Jonathan, additional, and Weng, Stephen, additional
- Published
- 2021
- Full Text
- View/download PDF
43. HMR1402, a potassium ATP channel blocker during hyperdynamic porcine endotoxemia: effects on hepato-splanchnic oxygen exchange and metabolism
- Author
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Asfar, Pierre, Iványi, Zsolt, Bracht, Hendrik, Hauser, Balázs, Pittner, Antje, Vassilev, Damian, Nalos, Marek, Leverve, Xavier Maurice, Brückner, Uwe Bernd, Radermacher, Peter, and Fröba, Gebhard
- Published
- 2004
- Full Text
- View/download PDF
44. Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis: A cohort study
- Author
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Herwanto, Velma, primary, Wang, Ya, additional, Shojaei, Maryam, additional, Khan, Alamgir, additional, Lai, Kevin, additional, Shetty, Amith, additional, Huang, Stephen, additional, Chew, Tracy, additional, Teoh, Sally, additional, Nalos, Marek, additional, Chakraborty, Mandira, additional, McLean, Anthony S., additional, and Tang, Benjamin MP., additional
- Published
- 2020
- Full Text
- View/download PDF
45. Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia
- Author
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Pittner, Antje, Nalos, Marek, Asfar, Pierre, Yang, Yan, Ince, Can, Georgieff, Michael, Brückner, Uwe, Radermacher, Peter, and Fröba, Gebhard
- Published
- 2003
- Full Text
- View/download PDF
46. Adenosine triphosphate–magnesium chloride: relevance for intensive care
- Author
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Nalos, Marek, Asfar, Pierre, Ichai, Carole, Radermacher, Peter, Leverve, Xavier, and Fröba, Gebhard
- Published
- 2003
- Full Text
- View/download PDF
47. Immune Effects of Interferon Gamma in Persistent Staphylococcal Sepsis
- Author
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Nalos, Marek, Santner-Nanan, Brigitte, Parnell, Grant, Tang, Benjamin, McLean, Anthony S., and Nanan, Ralph
- Published
- 2012
- Full Text
- View/download PDF
48. COVID-US: a simplified cardiopulmonary ultrasound approach to use in suspected and confirmed COVID-19
- Author
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Nalos, Marek, primary
- Published
- 2020
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49. COVID‐US: A simplified approach to cardiopulmonary ultrasound in suspected and confirmed COVID‐19 patients in surge crisis
- Author
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Yang, Yang, primary, Anstey, James, additional, Yastrebov, Konstantin, additional, Nanjayya, Vinodh Bhagyalakshmi, additional, Orde, Sam, additional, Nalos, Marek, additional, Costello, Cartan, additional, and Ryan, Nicholas Patrick George, additional
- Published
- 2020
- Full Text
- View/download PDF
50. Long‐term patient‐important outcomes after septic shock: A protocol for 1‐year follow‐up of the CLASSIC trial
- Author
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Kjær, Maj‐Brit N., primary, Meyhoff, Tine S., additional, Madsen, Martin B., additional, Hjortrup, Peter B., additional, Møller, Morten Hylander, additional, Egerod, Ingrid, additional, Wetterslev, Jørn, additional, Lange, Theis, additional, Cronhjort, Maria, additional, Laake, Jon H., additional, Jakob, Stephan M., additional, Nalos, Marek, additional, Pettilä, Ville, additional, van der Horst, Iwan C. C., additional, Ostermann, Marlies, additional, Mouncey, Paul, additional, Cecconi, Maurizio, additional, Ferrer, Ricard, additional, Malbrain, Manu L. N. G., additional, Ahlstedt, Christian, additional, Hoffmann, Søren, additional, Bestle, Morten H., additional, Gyldensted, Louise, additional, Nebrich, Lars, additional, Russell, Lene, additional, Vang, Marianne, additional, Sølling, Christoffer, additional, Brøchner, Anne C., additional, Rasmussen, Bodil S., additional, and Perner, Anders, additional
- Published
- 2019
- Full Text
- View/download PDF
Catalog
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