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39 results on '"Nakasatomi, Masao"'

1. Clinical differences among patients with myeloperoxidase–antineutrophil cytoplasmic antibody–positive interstitial lung disease

Author

Yamaguchi, Koichi, Yamaguchi, Aya, Ito, Masashi, Wakamatsu, Ikuo, Itai, Miki, Muto, Sohei, Uno, Shogo, Aikawa, Masaki, Kouno, Shunichi, Takemura, Masao, Yatomi, Masakiyo, Aoki-Saito, Haruka, Koga, Yasuhiko, Hara, Kenichiro, Motegi, Shinsuke, Tsukida, Mayuko, Ota, Fumie, Tsukada, Yoshito, Motegi, Mitsuru, Nakasatomi, Masao, Sakairi, Toru, Ikeuchi, Hidekazu, Kaneko, Yoriaki, Hiromura, Keiju, and Maeno, Toshitaka

Published
2023
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2. Quantitative CT analysis of interstitial pneumonia in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: a single center, retrospective study

Author

Yamaguchi, Koichi, Nakajima, Takahito, Yamaguchi, Aya, Itai, Miki, Onuki, Yuji, Shin, Yuki, Uno, Shogo, Muto, Sohei, Kouno, Shunichi, Yatomi, Masakiyo, Aoki-Saito, Haruka, Hara, Kenichiro, Endo, Yukie, Motegi, Sei-ichiro, Muro, Yoshinao, Nakasatomi, Masao, Sakairi, Toru, Hiromura, Keiju, Katsumata, Natsumi, Hirasawa, Hiromi, Tsushima, Yoshito, and Maeno, Toshitaka

Published
2022
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3. Influence of obesity in interstitial lung disease associated with anti-aminoacyl-tRNA synthetase antibodies

Author

Yamaguchi, Koichi, Fukushima, Yasuhiro, Yamaguchi, Aya, Itai, Miki, Shin, Yuki, Uno, Shogo, Muto, Sohei, Kouno, Shunichi, Tsurumaki, Hiroaki, Yatomi, Masakiyo, Aoki-Saito, Haruka, Hara, Kenichiro, Koga, Yasuhiko, Sunaga, Noriaki, Endo, Yukie, Motegi, Sei-ichiro, Nakasatomi, Masao, Sakairi, Toru, Ikeuchi, Hidekazu, Hiromura, Keiju, Hisada, Takeshi, Tsushima, Yoshito, Kuwana, Masataka, and Maeno, Toshitaka

Published
2022
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4. Interstitial lung disease with myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis in elderly patients

Author

Yamaguchi, Koichi, Yamaguchi, Aya, Itai, Miki, Onuki, Yuji, Shin, Yuki, Uno, Shogo, Hanazato, Chiharu, Taguchi, Kohei, Umetsu, Kazue, Aikawa, Masaki, Kouno, Shunichi, Takemura, Masao, Hara, Kenichiro, Motegi, Shinsuke, Tsukida, Mayuko, Ota, Fumie, Tsukada, Yoshito, Motegi, Mitsuru, Nakasatomi, Masao, Sakairi, Toru, Ikeuchi, Hidekazu, Kaneko, Yoriaki, Hiromura, Keiju, and Maeno, Toshitaka

Published
2021
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7. Clinical features of patients with anti-melanoma differentiation-associated gene-5 antibody-positive dermatomyositis complicated by spontaneous pneumomediastinum

Author

Yamaguchi, Koichi, Yamaguchi, Aya, Itai, Miki, Kashiwagi, Chiharu, Takehara, Kazutaka, Aoki, Shuhei, Sawada, Yuri, Taguchi, Kohei, Umetsu, Kazue, Oshima, Kazuma, Uchida, Megumi, Takemura, Masao, Hara, Kenichiro, Motegi, Sei-ichiro, Muro, Yoshinao, Nakasatomi, Masao, Sakairi, Toru, Hiromura, Keiju, Kurabayashi, Masahiko, and Maeno, Toshitaka

Published
2019
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9. Clinical differences among patients with myeloperoxidase–antineutrophil cytoplasmic antibody–positive interstitial lung disease

Author

Yamaguchi, Koichi, primary, Yamaguchi, Aya, additional, Ito, Masashi, additional, Wakamatsu, Ikuo, additional, Itai, Miki, additional, Muto, Sohei, additional, Uno, Shogo, additional, Aikawa, Masaki, additional, Kouno, Shunichi, additional, Takemura, Masao, additional, Yatomi, Masakiyo, additional, Aoki-Saito, Haruka, additional, Koga, Yasuhiko, additional, Hara, Kenichiro, additional, Motegi, Shinsuke, additional, Tsukida, Mayuko, additional, Ota, Fumie, additional, Tsukada, Yoshito, additional, Motegi, Mitsuru, additional, Nakasatomi, Masao, additional, Sakairi, Toru, additional, Ikeuchi, Hidekazu, additional, Kaneko, Yoriaki, additional, Hiromura, Keiju, additional, and Maeno, Toshitaka, additional

Published
2022
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13. Clinical features of dermatomyositis associated with anti-MDA5 antibodies by age

Author

Yamaguchi, Koichi, primary, Yamaguchi, Aya, additional, Onuki, Yuji, additional, Itai, Miki, additional, Kashiwagi, Chiharu, additional, Takehara, Kazutaka, additional, Aoki, Shuhei, additional, Kanaya, Azusa, additional, Taguchi, Kohei, additional, Umetsu, Kazue, additional, Oshima, Kazuma, additional, Uchida, Megumi, additional, Kimura, Hayato, additional, Kasahara, Morimitsu, additional, Takemura, Masao, additional, Hara, Kenichiro, additional, Sekiguchi, Akiko, additional, Motegi, Sei-ichiro, additional, Muro, Yoshinao, additional, Nakasatomi, Masao, additional, Motohashi, Rena, additional, Sakairi, Toru, additional, Nakagawa, Junichi, additional, Hiromura, Keiju, additional, Obokata, Masaru, additional, Kurabayashi, Masahiko, additional, and Maeno, Toshitaka, additional

Published
2020
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14. Primary central nervous system lymphoma in a patient with neuropsychiatric systemic lupus erythematosus receiving mycophenolate mofetil: A case report and literature review.

Author

Sakairi, Toru, Nakasatomi, Masao, Watanabe, Mitsuharu, Hamatani, Hiroko, Ikeuchi, Hidekazu, Kaneko, Yoriaki, Handa, Hiroshi, and Hiromura, Keiju

Subjects
*CENTRAL nervous system, *LITERATURE reviews, *LUPUS nephritis, *DIFFUSE large B-cell lymphomas, *MYCOPHENOLIC acid, *SYSTEMIC lupus erythematosus, *LYMPHOMAS
Published
2022
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18. The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature

Author

Tabei, Akifumi, primary, Watanabe, Mitsuharu, additional, Ikeuchi, Hidekazu, additional, Nakasatomi, Masao, additional, Sakairi, Toru, additional, Kaneko, Yoriaki, additional, Maeshima, Akito, additional, Kaira, Kyoichi, additional, Hirato, Junko, additional, Nojima, Yoshihisa, additional, and Hiromura, Keiju, additional

Published
2018
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19. Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review

Author

Ikeuchi, Hidekazu, primary, Koinuma, Kana, additional, Nakasatomi, Masao, additional, Sakairi, Toru, additional, Kaneko, Yoriaki, additional, Maeshima, Akito, additional, Yamazaki, Yuichi, additional, Okamoto, Hiroaki, additional, Mimura, Toshihide, additional, Mochida, Satoshi, additional, Nojima, Yoshihisa, additional, and Hiromura, Keiju, additional

Published
2018
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22. Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury

Author

Maeshima, Akito, Takahashi, Shunsuke, Nakasatomi, Masao, and Nojima, Yoshihisa

Subjects
Article Subject, urogenital system
Abstract

Renal tubular epithelium has the capacity to regenerate, repair, and reepithelialize in response to a variety of insults. Previous studies with several kidney injury models demonstrated that various growth factors, transcription factors, and extracellular matrices are involved in this process. Surviving tubular cells actively proliferate, migrate, and differentiate in the kidney regeneration process after injury, and some cells express putative stem cell markers or possess stem cell properties. Using fate mapping techniques, bone marrow-derived cells and endothelial progenitor cells have been shown to transdifferentiate into tubular components in vivo or ex vivo. Similarly, it has been demonstrated that, during tubular cell regeneration, several inflammatory cell populations migrate, assemble around tubular cells, and interact with tubular cells during the repair of tubular epithelium. In this review, we describe recent advances in understanding the regeneration mechanisms of renal tubules, particularly the characteristics of various cell populations contributing to tubular regeneration, and highlight the targets for the development of regenerative medicine for treating kidney diseases in humans.

Published
2015
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23. Regenerative Medicine for the Kidney: Renotropic Factors, Renal Stem/Progenitor Cells, and Stem Cell Therapy

Author

Maeshima, Akito, Nakasatomi, Masao, and Nojima, Yoshihisa

Subjects
Article Subject, urogenital system
Abstract

The kidney has the capacity for regeneration and repair after a variety of insults. Over the past few decades, factors that promote repair of the injured kidney have been extensively investigated. By using kidney injury animal models, the role of intrinsic and extrinsic growth factors, transcription factors, and extracellular matrix in this process has been examined. The identification of renal stem cells in the adult kidney as well as in the embryonic kidney is an active area of research. Cell populations expressing putative stem cell markers or possessing stem cell properties have been found in the tubules, interstitium, and glomeruli of the normal kidney. Cell therapies with bone marrow-derived hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, and amniotic fluid-derived stem cells have been highly effective for the treatment of acute or chronic renal failure in animals. Embryonic stem cells and induced pluripotent stem cells are also utilized for the construction of artificial kidneys or renal components. In this review, we highlight the advances in regenerative medicine for the kidney from the perspective of renotropic factors, renal stem/progenitor cells, and stem cell therapies and discuss the issues to be solved to realize regenerative therapy for kidney diseases in humans.

Published
2014
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27. A study on dietary therapy in chronic kidney disease

Author

Uehara, Yumi, primary, Shimada, Mikiko, additional, Yanagisawa, Kazumi, additional, Uchiyama, Kazuhiko, additional, Takeuchi, Shigeru, additional, Nogiwa, Eishi, additional, Nakasatomi, Masao, additional, Suzuno, Hiroko, additional, and Ishida, Hiroshi, additional

Published
2014
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28. Follistatin, an Activin Antagonist, Ameliorates Renal Interstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction

Author

Maeshima, Akito, primary, Mishima, Keiichiro, additional, Yamashita, Shin, additional, Nakasatomi, Masao, additional, Miya, Masaaki, additional, Sakurai, Noriyuki, additional, Sakairi, Toru, additional, Ikeuchi, Hidekazu, additional, Hiromura, Keiju, additional, Hasegawa, Yoshihisa, additional, Kojima, Itaru, additional, and Nojima, Yoshihisa, additional

Published
2014
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37. The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.

Author

Tabei A, Sakairi T, Hamatani H, Ohishi Y, Watanabe M, Nakasatomi M, Ikeuchi H, Kaneko Y, Kopp JB, and Hiromura K

Subjects
Animals, Humans, Mice, TOR Serine-Threonine Kinases metabolism, WT1 Proteins genetics, WT1 Proteins metabolism, Diabetes Mellitus, Type 2 metabolism, Diabetic Nephropathies metabolism, MicroRNAs metabolism, Podocytes metabolism, Transforming Growth Factor beta1 metabolism
Abstract

Transforming growth factor (TGF)-β1 contributes to podocyte injury in various glomerular diseases, including diabetic kidney disease, probably at least in part by attenuating the expression of Wilms' tumor 1 (WT1). However, the precise mechanisms remain to be defined. We performed miRNA microarray analysis in a human podocyte cell line cultured with TGF-β1 to examine the roles of miRNAs in podocyte damage. The microarray analysis identified miR-143-3p as the miRNA with the greatest increase following exposure to TGF-β1. Quantitative RT-PCR confirmed a significant increase in the miR-143-3p/145-5p cluster in TGF-β1-supplemented cultured podocytes and demonstrated upregulation of miR-143-3p in the glomeruli of mice with type 2 diabetes. Ectopic expression of miR-143-3p and miR-145-5p suppressed WT1 expression in cultured podocytes. Furthermore, inhibition of Smad or mammalian target of rapamycin signaling each partially reversed the TGF-β1-induced increase in miR-143-3p/145-5p and decrease in WT1. In conclusion, TGF-β1 induces expression of miR-143-3p/145-5p in part through Smad and mammalian target of rapamycin pathways, and miR-143-3p/145-5p reduces expression of WT1 in cultured human podocytes. miR-143-3p/145-5p may contribute to TGF-β1-induced podocyte injury. NEW & NOTEWORTHY This study by miRNA microarray analysis demonstrated that miR-143-3p expression was upregulated in cultured human podocytes following exposure to transforming growth factor (TGF)-β1. Furthermore, we report that the miR-143/145 cluster contributes to decreased expression of Wilms' tumor 1, which represents a possible mechanism for podocyte injury induced by TGF-β1. This study is important because it presents a novel mechanism for TGF-β-associated glomerular diseases, including diabetic kidney disease (DKD), and suggests potential therapeutic strategies targeting miR-143-3p/145-5p.

Published
2023
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38. Otitis media with ANCA-associated vasculitis: A retrospective study of 30 patients.

Author

Tabei A, Sakairi T, Ohishi Y, Watanabe M, Nakasatomi M, Hamatani H, Ikeuchi H, Kaneko Y, and Hiromura K

Subjects
Antibodies, Antineutrophil Cytoplasmic, Humans, Myeloblastin, Peroxidase, Retrospective Studies, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis drug therapy, Meningitis, Otitis Media complications, Otitis Media therapy
Abstract

Objectives: Otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) is a new category of otitis media in which cases of otitis media due to ANCA-associated vasculitis (AAV) are classified, regardless of ANCA variant or ANCA serotype. We aimed to describe the clinical features and course of patients with OMAAV and identify factors associated with hearing outcomes., Methods: We retrospectively analysed 30 patients with OMAAV, classified based on the criteria proposed by the Japan Otological Society in 2016., Results: Single-positive myeloperoxidase-ANCA, single-positive proteinase 3-ANCA, double-positive ANCA, and double-negative ANCA were identified in 47%, 33%, 7%, and 13% of the patients, respectively. All patients subjected to audiometry showed hearing impairments, and 85% were affected bilaterally. Mixed- and sensorineural-type hearing impairments were identified in 80% and 20% of impaired ears, respectively. Hypertrophic pachymeningitis (HPM) was identified in 37% of the patients. Immunosuppressive therapy was administered to 93% of patients, and the median air conduction hearing levels at pre- and post-treatment were 66.1 dB and 43.4 dB, respectively, indicating significant hearing improvements. HPM and a long interval between disease onset and treatment initiation were significantly correlated with poor hearing prognosis., Conclusions: OMAAV develops under any type of ANCA-serology and typically causes mixed or sensorineural bilateral hearing loss. The early initiation of immunosuppressive therapy and the absence of HPM were associated with good hearing outcomes., (© Japan College of Rheumatology 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2022
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39. Clinical features of dermatomyositis associated with anti-MDA5 antibodies by age.

Author

Yamaguchi K, Yamaguchi A, Onuki Y, Itai M, Kashiwagi C, Takehara K, Aoki S, Kanaya A, Taguchi K, Umetsu K, Oshima K, Uchida M, Kimura H, Kasahara M, Takemura M, Hara K, Sekiguchi A, Motegi SI, Muro Y, Nakasatomi M, Motohashi R, Sakairi T, Nakagawa J, Hiromura K, Obokata M, Kurabayashi M, and Maeno T

Subjects
Adult, Age Factors, Aged, Dermatomyositis drug therapy, Dermatomyositis epidemiology, Dermatomyositis immunology, Female, Humans, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Mortality, Autoantibodies immunology, Dermatomyositis pathology, Interferon-Induced Helicase, IFIH1 immunology
Abstract

Objectives: Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody-positive and age at onset ≥60 years are poor prognosis factors in polymyositis (PM) and dermatomyositis (DM) associated with interstitial lung disease (ILD) among Japanese patients. However, the influence of age on the clinical features of anti-MDA5 autoantibody-positive patients with DM remains unclear., Methods: We retrospectively examined 40 patients with DM and anti-MDA5 autoantibodies according to age. We compared patients aged <60 and ≥60 years with respect to clinical features including laboratory test findings, high-resolution lung computed tomography data, treatment content, and complications such as infections and prognosis. We also examined clinical features between surviving and deceased patients in the older patient group., Results: Of 40 enrolled patients, 13 were classified as old and 27 as young. Older patients had significantly fewer clinical symptoms including arthralgia/arthritis ( p  < .01), skin ulceration ( p  = .02), and higher mortality than younger patients ( p  = .02) complicated with rapidly progressive ILD (RP-ILD), combination immunosuppressive therapy, and strictly controlled infections., Conclusion: Clinical features and mortality of anti-MDA5 autoantibody-positive DM patients were influenced by age. Patients aged ≥60 years had a worse prognosis, and combination immunosuppressive therapy was often ineffective for RP-ILD in older patients.

Published
2021
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