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468 results on '"Mukai Tsuyoshi"'

1. A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus

Author

Hamada Kazu, Shimode Yuzo, Hata Yoshiyuki, Kunou Hiroaki, Kobayashi Rika, Matsunaga Kazuhiro, Kawaura Ken, Mukai Tsuyoshi, Kitakata Hidekazu, Itoh Tohru, Okuro Masashi, and Yamada Sohsuke

Subjects
biopsy, endoscopy, esophagus, hypopharynx, neurofibroma, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract A 50‐year‐old female was admitted to our hospital because of mild throat discomfort. Esophagogastroduodenoscopy demonstrated multiple 2–3 mm diameter whitish granules in her hypopharynx and cervical esophagus. Based on biopsy specimens, we considered the lesions to represent normal tissue or very mild mucosal dysplasia. However, S‐100 immunohistochemical staining 3 years later led to a diagnosis of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus. Histological finding characteristics of neurofibroma were present in 72.7% of hypopharyngeal biopsy specimens and 33.3% of esophageal specimens. When diagnosing neurofibroma, it is important to perform biopsies at multiple locations and at different times and to enlist the cooperation of endoscopists and pathologists for immunohistochemical staining with S‐100.

Published
2023
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4. Artificial intelligence–based skeletal muscle estimates and outcomes of EUS-guided treatment of pancreatic fluid collections

Author

Sakai, Arata, Nakano, Ryota, Iwasa, Yuhei, Takenaka, Mamoru, Gonoi, Wataru, Sato, Tatsuya, Saito, Tomotaka, Hanaoka, Shouhei, Hamada, Tsuyoshi, Omoto, Shunsuke, Masuda, Atsuhiro, Tsujimae, Masahiro, Iwashita, Takuji, Uemura, Shinya, Ota, Shogo, Shiomi, Hideyuki, Fujisawa, Toshio, Takahashi, Sho, Matsubara, Saburo, Suda, Kentaro, Maruta, Akinori, Yoshida, Kensaku, Iwata, Keisuke, Okuno, Mitsuru, Hayashi, Nobuhiko, Mukai, Tsuyoshi, Isayama, Hiroyuki, Yasuda, Ichiro, and Nakai, Yousuke

Published
2024
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7. WONDER-01: immediate necrosectomy vs. drainage-oriented step-up approach after endoscopic ultrasound-guided drainage of walled-off necrosis—study protocol for a multicentre randomised controlled trial

Author

Sato, Tatsuya, Saito, Tomotaka, Takenaka, Mamoru, Iwashita, Takuji, Shiomi, Hideyuki, Fujisawa, Toshio, Hayashi, Nobuhiko, Iwata, Keisuke, Maruta, Akinori, Mukai, Tsuyoshi, Masuda, Atsuhiro, Matsubara, Saburo, Hamada, Tsuyoshi, Inoue, Tadahisa, Ohyama, Hiroshi, Kuwatani, Masaki, Kamada, Hideki, Hashimoto, Shinichi, Shiratori, Toshiyasu, Yamada, Reiko, Kogure, Hirofumi, Ogura, Takeshi, Nakahara, Kazunari, Doi, Shinpei, Chinen, Kenji, Isayama, Hiroyuki, Yasuda, Ichiro, and Nakai, Yousuke

Published
2023
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9. Prospective multicenter surveillance study of branch-duct intraductal papillary mucinous neoplasm of the pancreas; risk of dual carcinogenesis

Author

Ohtsuka, Takao, Maguchi, Hiroyuki, Tokunaga, Shoji, Hijioka, Susumu, Takayama, Yukiko, Koshita, Shinsuke, Hanada, Keiji, Sudo, Kentaro, Uehara, Hiroyuki, Tanno, Satoshi, Tada, Minoru, Kimura, Wataru, Nakamura, Masafumi, Kin, Toshifumi, Kamata, Ken, Masamune, Atsushi, Iwashita, Takuji, Akahoshi, Kazuya, Ueki, Toshiharu, Okamura, Keiya, Kato, Hironari, Kumagi, Teru, Kawabe, Ken, Yoshida, Koji, Mukai, Tsuyoshi, Sakagami, Junichi, Hirono, Seiko, Abue, Makoto, Nakafusa, Tomoki, Morita, Makiko, Shimosegawa, Toru, and Tanaka, Masao

Published
2024
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10. Utility of bilateral intraductal plastic stent for malignant hilar biliary obstruction compared with bilateral self-expandable metal stent: a propensity score–matched cohort analysis

Author

Okuno, Mitsuru, Iwata, Keisuke, Iwashita, Takuji, Mukai, Tsuyoshi, Shimojo, Kota, Ohashi, Yosuke, Iwasa, Yuhei, Senju, Akihiko, Iwata, Shota, Tezuka, Ryuichi, Ichikawa, Hironao, Mita, Naoki, Uemura, Shinya, Yoshida, Kensaku, Maruta, Akinori, Tomita, Eiichi, Yasuda, Ichiro, and Shimizu, Masahito

Published
2023
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11. Supportive treatment during the periprocedural period of endoscopic treatment for pancreatic fluid collections: a critical review of current knowledge and future perspectives

Author

Iwashita, Takuji, Iwata, Keisuke, Hamada, Tsuyoshi, Saito, Tomotaka, Shiomi, Hideyuki, Takenaka, Mamoru, Maruta, Akinori, Uemura, Shinya, Masuda, Atsuhiro, Matsubara, Saburo, Mukai, Tsuyoshi, Takahashi, Sho, Hayashi, Nobuhiko, Isayama, Hiroyuki, Yasuda, Ichiro, and Nakai, Yousuke

Published
2023
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15. Risk of Pancreatitis Following Biliary Stenting With/Without Endoscopic Sphincterotomy: A Randomized Controlled Trial

Author

Kato, Shin, Kuwatani, Masaki, Onodera, Manabu, Kudo, Taiki, Sano, Itsuki, Katanuma, Akio, Uebayashi, Minoru, Eto, Kazunori, Fukasawa, Mitsuharu, Hashigo, Shunpei, Iwashita, Takuji, Yoshida, Makoto, Taya, Yoko, Kawakami, Hiroshi, Kato, Hironari, Nakai, Yousuke, Kobashigawa, Kasen, Kawahata, Shuhei, Shinoura, Susumu, Ito, Kei, Kubo, Kimitoshi, Yamato, Hiroaki, Hara, Kazuo, Maetani, Iruru, Mukai, Tsuyoshi, Shibukawa, Goro, and Itoi, Takao

Published
2022
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17. Evaluating optimal bilateral biliary stenting in endoscopic reintervention after initial plastic stent dysfunction for unresectable malignant hilar biliary obstruction: Retrospective cross‐sectional study.

Author

Okuno, Mitsuru, Iwata, Keisuke, Iwashita, Takuji, Mukai, Tsuyoshi, Shimojo, Kota, Ohashi, Yosuke, Iwasa, Yuhei, Senju, Akihiko, Iwata, Shota, Tezuka, Ryuichi, Ichikawa, Hironao, Mita, Naoki, Uemura, Shinya, Yoshida, Kensaku, Maruta, Akinori, Tomita, Eiichi, Yasuda, Ichiro, and Shimizu, Masahito

Subjects
OVERALL survival, MULTIVARIATE analysis, CONFIDENCE intervals, DRAINAGE, RETROSPECTIVE studies
Abstract

Objectives: The placement of plastic stents (PS), including intraductal PS (IS), is useful in patients with unresectable malignant hilar biliary obstruction (UMHBO) because of patency and ease of endoscopic reintervention (ERI). However, the optimal stent replacement method for PS remains unclear. Methods: This retrospective study included 322 patients with UMHBO. Among them, 146 received PS placement as initial drainage (across‐the‐papilla PS [aPS], 54; IS, 92), whereas 75 required ERI. Eight bilateral aPS, 21 bilateral IS, and 17 bilateral self‐expandable metallic stent (SEMS) placements met the inclusion criteria. Rates of technical and clinical success, adverse events, recurrent biliary obstruction (RBO), time to RBO (TRBO), overall survival, and secondary ERI were compared. Results: There were no significant intergroup differences in rates of technical or clinical success, adverse events, RBO occurrence, or overall survival. The median TRBO was significantly shorter in the aPS group (47 days) than IS (91 days; P = 0.0196) and SEMS (143 days; P < 0.01) groups. Median TRBO did not differ significantly between the IS and SEMS groups (P = 0.44). On Cox multivariate analysis, the aPS group had the shortest stent patency (hazard ratio 2.67 [95% confidence interval 1.05–6.76], P = 0.038). For secondary ERI, the median endoscopic procedure time was significantly shorter in the IS (22 min) vs. SEMS (40 min) group (P = 0.034). Conclusions: Bilateral IS and SEMS placement featured prolonged patency after first ERI. Because bilateral IS placement is faster than SEMS placement and IS can be removed during secondary ERI, it may be a good option for first ERI. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

Author

Furumatsu, Keisuke, Sawai, Shigeaki, Goto, Takuma, Okumura, Toshikatsu, Suzuki, Daisuke, Otsuka, Masayuki, Kobori, Ikuhiro, Tamano, Masaya, Koizumi, Mitsuhito, Hiasa, Yoichi, Kawabe, Naoto, Hirooka, Yoshiki, Yamamoto, Satoshi, Asano, Yukio, Inui, Kazuo, Horiguchi, Akihiko, Watanabe, Hiroyuki, Toya, Daishu, Hatayama, Katsuko, Ueki, Toshiharu, Kinoshita, Norikatsu, Sugimoto, Mitsuru, Ohira, Hiromasa, Mukai, Tsuyoshi, Tomita, Eiichi, Iwata, Keisuke, Shimizu, Shogo, Suetsugu, Jun, Shimizu, Masahito, Tsuji, Keiji, Ishida, Ryoko, Ito, Masanori, Furukawa, Ryutaro, Sakamoto, Naoya, Araki, Masahiro, Tanno, Satoshi, Sakamoto, Yasunari, Ito, Tetsuhide, Takai, Satoshi, Ikeya, Shinichi, Yamada, Takanori, Kudara, Norihiko, Shimizu, Akinori, Hanada, Keiji, Ichiki, Yasunori, Kitada, Hideki, Hifumi, Michio, Kimura, Hiroyuki, Kurosaki, Masayuki, Izumi, Namiki, Sumi, Hajime, Haruta, Jun-ichi, Hayashi, Katsumi, Harada, Ryo, Inoue, Masafumi, Nakamura, Shinichiro, Ito, Tetsuya, Tomishima, Ko, Isayama, Hiroyuki, Oura, Kyoko, Masaki, Tsutomu, Shimokawahara, Naoto, Tanoue, Shirou, Maemura, Kousei, Ido, Akio, Mizushima, Ichiro, Kawano, Mitsuhiro, Yoshida, Katsunori, Naganuma, Makoto, Murata, Miki, Nishio, Akiyoshi, Fujita, Yuji, Teratani, Takuma, Matsubara, Shohei, Tamai, Hironao, Yoshida, Yuu, Azemoto, Ryousaku, Kamata, Ken, Watanabe, Tomohiro, Kurosu, Takahiro, Koizumi, Wasaburou, Fujita, Jun, Seki, Hideyuki, Ueda, Yasuhiro, Fukumoto, Takumi, Kousaki, Takuhiro, Uchida, Kazushige, Ochiai, Toshimasa, Kawasaki, Takeshi, Tanaka, Motohiko, Ishida, Etsuji, Notohara, Kenji, Mori, Hideaki, Mori, Toshiyuki, Kawabata, Hideaki, Miyata, Masatoshi, Sakagami, Junichi, Itoh, Yoshito, Shiokawa, Masahiro, Seno, Hiroshi, Watanabe, Noriko, Naitoh, Itaru, Kataoka, Hiromi, Aoki, Toshinori, Fujishiro, Mitsuhiro, Niihara, Toru, Nishimata, Hiroto, Mitoro, Akira, Yoshiji, Hitoshi, Yoshida, Motoyuki, Ikeda, Masafumi, Tomita, Kengo, Hokari, Ryota, Hayasaka, Kenji, Amano, Yuji, Shioji, Kazuhiko, Hayashi, Kazunao, Terai, Shuji, Nakajima, Michiko, Yamahana, Junya, Matsumoto, Ryusuke, Kikuchi, Hideaki, Kanamori, Akira, Kiriyama, Seiki, Iwatsu, Shinichi, Kato, Yuji, Horiguchi, Shigeru, Yagi, Takahito, Okada, Hiroyuki, Ohkawa, Kazuyoshi, Hirao, Motohiro, Hiramatsu, Naoki, Oza, Noriko, Imamura, Haruo, Baba, Takeshi, Nakano, Shigeru, Shinobi, Tetsuya, Ryozawa, Shomei, Motoya, Masayo, Nakase, Hiroshi, Kinoshita, Noboru, Ito, Kei, Miyake, Tatsuya, Kohge, Naruaki, Tobita, Hiroshi, Joshita, Satoru, Umemura, Takeji, Kawaguchi, Shinya, Ohno, Kazuya, Sonobe, Koichi, Satoh, Akihiko, Shimosegawa, Tooru, Miura, Fumihiko, Yagi, Minami, Sano, Keiji, Tanaka, Atsushi, Kin, Toshifumi, Katanuma, Akio, Koike, Kazuhiko, Miura, Shin, Masamune, Atsushi, Kawashima, Youhei, Kagawa, Tatehiro, Azuma, Seishin, Watanabe, Mamoru, Honjyo, Mitsuyoshi, Itoi, Takao, Honda, Akira, Kobayashi, Katsumasa, Asano, Toru, Kamisawa, Terumi, Mizuno, Suguru, Nishino, Takayoshi, Taniguchi, Hideaki, Tajiri, Kazuto, Yasuda, Ichiro, Tanaka, Yoshiya, Oe, Shinji, Harada, Masaru, Kurata, Masanao, Fukasawa, Mituharu, Enomoto, Nobuyuki, Kawaji, Yuki, Kitano, Masayuki, Nishise, Yuko, Hirakawa, Hidetoshi, Ishizawa, Tetsuya, Ueno, Yoshiyuki, Kaino, Miyuki, Fujimoto, Yuko, Sakaida, Isao, Kubota, Kensuke, Nakazawa, Takahiro, Takikawa, Hajime, Unno, Michiaki, Kawa, Shigeyuki, Nakamura, Seiji, and Okazaki, Kazuichi

Published
2021
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19. WONDER-02: plastic stent vs. lumen-apposing metal stent for endoscopic ultrasound-guided drainage of pancreatic pseudocysts—study protocol for a multicentre randomised non-inferiority trial.

Author

Saito, Tomotaka, Takenaka, Mamoru, Kuwatani, Masaki, Doi, Shinpei, Ohyama, Hiroshi, Fujisawa, Toshio, Masuda, Atsuhiro, Iwashita, Takuji, Shiomi, Hideyuki, Hayashi, Nobuhiko, Iwata, Keisuke, Maruta, Akinori, Mukai, Tsuyoshi, Matsubara, Saburo, Hamada, Tsuyoshi, Inoue, Tadahisa, Matsumoto, Kazuyuki, Hirose, Sumio, Fujimori, Nao, and Kashiwabara, Kosuke

Subjects
LEUKOCYTE count, ENDOSCOPIC ultrasonography, PANCREATIC fistula, BLOOD proteins, MEDICAL drainage
Abstract

Background: Endoscopic ultrasound (EUS)-guided transluminal drainage has become a first-line treatment modality for symptomatic pancreatic pseudocysts. Despite the increasing popularity of lumen-apposing metal stents (LAMSs), plastic stents may resolve non-necrotic fluid collections effectively with lower costs and no LAMS-specific adverse events. To date, there has been a paucity of data on the appropriate stent type in this setting. This trial aims to assess the non-inferiority of plastic stents to a LAMS for the initial EUS-guided drainage of pseudocysts. Methods: The WONDER-02 trial is a multicentre, open-label, non-inferiority, randomised controlled trial, which will enrol pancreatic pseudocyst patients requiring EUS-guided treatment in 26 centres in Japan. This trial plans to enrol 80 patients who will be randomised at a 1:1 ratio to receive either plastic stents or a LAMS (40 patients per arm). In the plastic stent group, EUS-guided drainage will be performed using two 7-Fr double pigtail stents. In the LAMS group, the treatment will be performed in the same way except for LAMS use. The step-up treatment will be performed via endoscopic and/or percutaneous procedures at the trial investigator's discretion. The primary endpoint is clinical success, which is defined as a decrease in a pseudocyst size to ≤ 2 cm and an improvement in inflammatory indicators (i.e. body temperature, white blood cell count, and serum C-reactive protein). Secondary endpoints include technical success, adverse events including mortality, pseudocyst recurrence, and medical costs. Discussion: The WONDER-02 trial will investigate the efficacy and safety of plastic stents compared to a LAMS in EUS-guided treatment of symptomatic pancreatic pseudocysts with a particular focus on the non-inferior efficacy of plastic stents. The findings will help establish a new treatment algorithm for this population. Trial registration: ClinicalTrials.gov NCT06133023 registered on 9 November 2023. UMIN000052647 registered on 30 October 2023. jRCT1032230444 registered on 7 November 2023. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Possibility of Cell Block Specimens from Overnight-Stored Bile for Next-Generation Sequencing of Cholangiocarcinoma.

Author

Okuno, Mitsuru, Kanayama, Tomohiro, Iwata, Keisuke, Tanaka, Takuji, Tomita, Hiroyuki, Iwasa, Yuhei, Shirakami, Yohei, Watanabe, Naoki, Mukai, Tsuyoshi, Tomita, Eiichi, and Shimizu, Masahito

Subjects
NUCLEOTIDE sequencing, CHOLANGIOCARCINOMA, GENETIC variation, POSSIBILITY
Abstract

The identification of anticancer therapies using next-generation sequencing (NGS) is necessary for the treatment of cholangiocarcinoma. NGS can be easily performed when cell blocks (CB) are obtained from bile stored overnight. We compared NGS results of paired CB and surgically resected specimens (SRS) from the same cholangiocarcinoma cases. Of the prospectively collected 64 bile CBs from 2018 to 2023, NGS was performed for three cases of cholangiocarcinoma that could be compared with the SRS results. The median numbers of DNA and RNA reads were 95,077,806 [CB] vs. 93,161,788 [SRS] and 22,101,328 [CB] vs. 24,806,180 [SRS], respectively. We evaluated 588 genes and found that almost all genetic alterations were attributed to single-nucleotide variants, insertions/deletions, and multi-nucleotide variants. The coverage rate of variants in SRS by those found in CB was 97.9–99.2%, and the coverage rate of SRS genes by CB genes was 99.6–99.7%. The NGS results of CB fully covered the variants and genetic alterations observed in paired SRS samples. As bile CB is easy to prepare in general hospitals, our results suggest the potential use of bile CB as a novel method for NGS-based evaluation of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Clinical practice of acute pancreatitis in Japan: An analysis of nationwide epidemiological survey in 2016

Author

Matsumoto, Ryotaro, Kume, Kiyoshi, Miura, Shin, Takikawa, Tetsuya, Hongo, Seiji, Tanaka, Yu, Sakai, Toshitaka, Ueno, Masayuki, Unno, Jun, Toki, Masao, Nishimura, Mamoru, Kitamura, Katsuya, Kobashigawa, Kasen, Ashida, Kiyoshi, Takahashi, Kuniyuki, Watanabe, Takashi, Sato, Yuichirou, Satoh, Akihiko, Yoshida, Naoki, Tanaka, Kei, Kondo, Hiromu, Suzuki, Noriaki, Sato, Hiroko, Mitoro, Akira, Minami, Kazuhiro, Iwasaki, Eisuke, Okuwaki, Kosuke, Mukai, Tsuyoshi, Kudo, Yasushi, Azuma, Shunjiro, Takeda, Yasuhito, Setsuda, Morimichi, Tsuchida, Kohei, Irisawa, Atsushi, Motoya, Daisuke, Shirahata, Nakao, Iwata, Keisuke, Oza, Noriko, Kawaguchi, Yasunori, Hoshino, Atsumi, Hirano, Atsuyuki, Sakakihara, Ichiro, Watanabe, Noriko, Funayama, Hiroyuki, Nakamura, Yuji, Yamamoto, Tatuo, Uchida, H.Hiroshi, Iizawa, Yusuke, Imamura, Mahiro, Sekine, Masanari, Inui, Kazuo, Yamamoto, Satoshi, Sato, Syuichi, Ishii, Shuji, Yakushijin, Takayuki, Yamamoto, Katsutoshi, Masaka, Tomohiro, Yoshida, Motoyuki, Arizumi, Toshihiko, Goto, Manabu, Takenaka, Mamoru, Miyakawa, Hiroyuki, Otsuka, Yuichiro, Nishi, Masaaki, Suwa, Kanetoshi, Sakagami, Junichi, Satoh, Masahiro, Koga, Hideaki, Takagi, Tadayuki, Nagahama, Masatsugu, Hatayama, Katsuko, Kaneko, Naoya, Mori, Masafumi, Nakai, Yousuke, Iwashita, Yuji, Iwatsuka, Kunio, Hayashi, Kazunao, Terai, Shuji, Kaneto, Hiroyuki, Nishikawa, Takao, Uchi, Midori, Honjo, Mitsuyoshi, Takagi, Tomofumi, Mizukami, Kazuhiro, Tamura, Tetsuo, Gushima, Toshifumi, Sato, Ai, Shimizu, Kyoko, Aruga, Yukio, Nonogaki, Kouji, Kaino, Miyuki, Iwashita, Takuji, Tsuruoka, Mio, Miura, Masato, Hasegawa, Hirofumi, Takai, Tetsunari, Yokota, Hiroyuki, Fujisawa, Toshio, Uetsuki, Kota, Kobayashi, Takashi, yamaji, Naohisa, Itoi, Takao, Muraki, Takashi, Watanabe, Takayuki, Inatomi, Osamu, Ushijima, Tomoyuki, Takehara, Yusuke, Kawamura, Hiroshi, Fukasawa, Mitsuharu, Hagiwara, Hideki, Tamura, Hiroyuki, Moriya, Takashi, Kuwatani, Masaki, Kawaji, Yuki, Kamisawa, Terumi, Abue, Makoto, Fukunishi, Masanori, Onoyama, Hirohiko, Mochizuki, Satoshi, Sumimoto, Kimi, Koyabu, Masanori, Nishio, Akiyoshi, Sakao, Masayuki, Imamura, Yoshiki, Ohta, Hajime, Nishimura, Naruo, Shiihara, Masahiro, Anan, Hideaki, Motoya, Masayo, Chiba, Mitsuru, Deguchi, Tomohiro, Kofunato, Yasuhide, Sawada, Naoya, Katada, Kazuhiro, Matsumoto, Shimpei, Higashide, Syunichi, Okano, Hiroyuki, Ishida, Masaharu, Yamazaki, Masato, Tamura, Naoshi, Muraoka, Takeshi, Uza, Norimitsu, Kodama, Yuzo, Muro, Shinichiro, Fujimori, Nao, Ikeda, Takaaki, Shimokawahara, Naoto, Otsu, Naoya, Yano, Yoichi, Sugawara, Shuichiro, Takaura, Kenta, Ogura, Yasuhiro, Furuuchi, Takayuki, Shibasaki, Masayuki, Kishimoto, Masanobu, Masamune, Atsushi, Kikuta, Kazuhiro, Hamada, Shin, Tsuji, Ichiro, Takeyama, Yoshifumi, Shimosegawa, Tooru, and Okazaki, Kazuichi

Published
2020
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22. Risk of recurrence with or without plastic stent after EUS-guided treatment of peripancreatic fluid collections: A systematic review and meta-analysis

Author

Iwashita, Takuji, primary, Sato, Tatsuya, primary, Yasuda, Ichiro, primary, Nakai, Yousuke, primary, Hamada, Tsuyoshi, additional, Saito, Tomotaka, additional, Iwata, Keisuke, additional, Shiomi, Hideyuki, additional, Takenaka, Mamoru, additional, Maruta, Akinori, additional, Uemura, Shinya, additional, Masuda, Atsuhiro, additional, Matsubara, Saburo, additional, Mukai, Tsuyoshi, additional, and Isayama, Hiroyuki, additional

Published
2023
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25. Peroral Pancreatoscopy-Guided Lithotripsy Compared with Extracorporeal Shock Wave Lithotripsy in the Management of Pancreatic Duct Stones in Chronic Pancreatitis: A Multicenter Retrospective Cohort Study.

Author

Iwata, Keisuke, Iwashita, Takuji, Mukai, Tsuyoshi, Iwasa, Yuhei, Okuno, Mitsuru, Yoshida, Kensaku, Maruta, Akinori, Uemura, Shinya, Yasuda, Ichiro, and Shimizu, Masahito

Subjects
EXTRACORPOREAL shock wave lithotripsy, PANCREATIC duct, CHRONIC pancreatitis, COHORT analysis
Abstract

Background: Extracorporeal shock wave lithotripsy (ESWL) is a common treatment for pancreatic stones in chronic pancreatitis. In contrast, peroral pancreatoscopy-guided lithotripsy (POPS-L) remains underexplored, with limited comparative studies to ESWL. This study compared the treatment outcomes of disposable POPS-L tools and ESWL for pancreatic stones. Methods: A retrospective analysis was conducted on 66 patients who had undergone pancreatic stone treatment at three institutions between 2006 and 2022. The treatment outcomes of POPS-L and ESWL were compared. Results: This study included 19 and 47 patients who had undergone POPS-L and ESWL, respectively. In a comparison between POPS-L and ESWL, the stone clearance rates were 78.9% vs. 70.2% (p = 0.55), while the procedure-related complication rates were 21% vs. 6.3% (p = 0.09). The median total session counts were 1 vs. 5 (p < 0.01). The cumulative stone recurrence rates were comparable in both groups. Multivariate analysis revealed no significant factors influencing the stone clearance rates, and the choice between POPS-L and ESWL did not affect the stone clearance rates. Conclusions: POPS-L and ESWL exhibited comparable treatment outcomes in terms of stone clearance, complications, and recurrence rates. Furthermore, POPS-L is advantageous due to the need for fewer sessions to achieve pancreatic stone clearance. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Comparison of 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma using endoscopic ultrasound fine-needle aspiration.

Author

Okuno, Mitsuru, Iwata, Keisuke, Mukai, Tsuyoshi, Kito, Yusuke, Tanaka, Takuji, Watanabe, Naoki, Kasahara, Senji, Iwasa, Yuhei, Sugiyama, Akihiko, Nishigaki, Youichi, Shibata, Yuhei, Kitagawa, Junichi, Iwashita, Takuji, Tomita, Eiichi, and Shimizu, Masahito

Subjects
ENDOSCOPIC ultrasonography, NEEDLE biopsy, LYMPHADENITIS, LYMPHOMAS, DIAGNOSIS, NEEDLES & pins
Abstract

Background/Aims: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using a 19-gauge needle is an efficient sampling method for the diagnosis of lymphadenopathy. This study compared 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma (ML). Methods: Patient characteristics, number of needle passes, puncture route, sensitivity, specificity, and accuracy of cytology/histology for lymphadenopathy were analyzed in patients diagnosed with lymphadenopathy by EUS-FNA using conventional or Franseen needles. Results: Between 2012 and 2022, 146 patients met the inclusion criteria (conventional [n=70] and Franseen [n=76]). The median number of needle passes was significantly lower in the conventional group than in the Franseen group (3 [1-6] vs. 4 [1-6], p=0.023). There were no significant differences in cytological/histological diagnoses between the two groups. For ML, the immunohistochemical evaluation rate, sensitivity of flow cytometry, and cytogenetic assessment were not significantly different in either group. Bleeding as adverse events (AEs) were observed in three patients in the Franseen group. Conclusions: Both the 19-gauge conventional and Franseen needles showed high accuracy in lymphadenopathy and ML classification. Considering sufficient tissue collection and the avoidance of AEs, the use of 19-gauge conventional needles seems to be a good option for the diagnosis of lymphadenopathy. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Comparison of unilateral and bilateral intraductal plastic stent placement for unresectable malignant hilar biliary obstruction: A propensity score‐matched cohort analysis.

Author

Okuno, Mitsuru, Iwata, Keisuke, Mukai, Tsuyoshi, Iwasa, Yuhei, Uemura, Shinya, Yoshida, Kensaku, Maruta, Akinori, Iwashita, Takuji, Yasuda, Ichiro, and Shimizu, Masahito

Abstract

Background: Although intraductal plastic stent (IS) placement is an effective treatment for unresectable malignant hilar biliary obstruction (UMHBO), the effectiveness of unilateral and bilateral IS drainage remains controversial. This retrospective study investigated the effectiveness of bilateral IS placement for UMHBO using the propensity score matching method. Methods: Patients who underwent transpapillary endoscopic stenting for UMHBO were analyzed for technical and clinical success, adverse events, and time to recurrent biliary obstruction (TRBO). Results: A total of 321 patients were enrolled in the study with 27 patients in each unilateral and bilateral IS group in the propensity score‐based cohort. Technical success was 100%, while clinical success was 93% and 96% in the unilateral and bilateral IS groups, respectively (p = 1.0). Cholecystitis occurred in 4% and 7%, respectively (p = 1.0). The median TRBO was shorter in the unilateral group (129 [5–383] days) than that in the bilateral group (226 [16–563] days) (p =.0281). Bilateral IS placement was an independent long TRBO factor (hazard ratio [HR] 0.46; 95% confidence interval [CI]: 0.21–0.97; p =.041). Conclusions: Unilateral and bilateral IS placement had high technical and clinical success rates in primary stent placement. However, bilateral IS placement showed a longer TRBO. Bilateral IS placement may be a good option for initial UMHBO drainage. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Comparison of unilateral and bilateral intraductal plastic stent placement for unresectable malignant hilar biliary obstruction: A propensity score‐matched cohort analysis

Author

Okuno, Mitsuru, primary, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Iwasa, Yuhei, additional, Uemura, Shinya, additional, Yoshida, Kensaku, additional, Maruta, Akinori, additional, Iwashita, Takuji, additional, Yasuda, Ichiro, additional, and Shimizu, Masahito, additional

Published
2023
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29. Comparison of covered self-expandable metallic stents with 12-mm and 10-mm diameters for unresectable malignant distal biliary obstructions: A prospective randomized trial

Author

Mukai, Tsuyoshi, primary, Iwata, Keisuke, additional, Iwashita, Takuji, additional, Doi, Shinpei, additional, Kawakami, Hiroshi, additional, Okuno, Mitsuru, additional, Maruta, Akinori, additional, Uemura, Shinya, additional, Shimizu, Masahito, additional, and Yasuda, Ichiro, additional

Published
2023
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30. Comparison of 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma using endoscopic ultrasound fine-needle aspiration

Author

Okuno, Mitsuru, primary, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Kito, Yusuke, additional, Tanaka, Takuji, additional, Watanabe, Naoki, additional, Kasahara, Senji, additional, Iwasa, Yuhei, additional, Sugiyama, Akihiko, additional, Nishigaki, Youichi, additional, Shibata, Yuhei, additional, Kitagawa, Junichi, additional, Iwashita, Takuji, additional, Tomita, Eiichi, additional, and Shimizu, Masahito, additional

Published
2023
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34. INVERSE ASSOCIATION OF HOSPITAL VOLUME WITH IN-HOSPITAL MORTALITY RATE OF PATIENTS RECEIVING ENDOSCOPIC ULTRASOUND-GUIDED INTERVENTIONS FOR PANCREATIC FLUID COLLECTIONS

Author

Saito, Tomotaka, primary, Hamada, Tsuyoshi, additional, Michihata, Nobuaki, additional, Iwashita, Takuji, additional, Shiomi, Hideyuki, additional, Takenaka, Mamoru, additional, Matsui, Hiroki, additional, Fushimi, Kiyohide, additional, Fujisawa, Toshio, additional, Matsubara, Saburo, additional, Maruta, Akinori, additional, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Isayama, Hiroyuki, additional, Yasuda, Ichiro, additional, Yasunaga, Hideo, additional, and Nakai, Yousuke, additional

Published
2023
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39. Response

Author

Okuno, Mitsuru, primary, Iwata, Keisuke, additional, and Mukai, Tsuyoshi, additional

Published
2023
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40. Comparing endoscopic ultrasound‐guided antegrade treatment and balloon endoscopy‐assisted endoscopic retrograde cholangiopancreatography in the management of bile duct stones in patients with surgically altered anatomy: A retrospective cohort study

Author

Iwashita, Takuji, primary, Iwasa, Yuhei, additional, Senju, Akihiko, additional, Tezuka, Ryuichi, additional, Uemura, Shinya, additional, Okuno, Mitsuru, additional, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Yasuda, Ichiro, additional, and Shimizu, Masahito, additional

Published
2023
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41. Management of Pancreatolithiasis: A Nationwide Survey in Japan

Author

Inui, Kazuo, Masamune, Atsushi, Igarashi, Yoshinori, Ohara, Hirotaka, Tazuma, Susumu, Sugiyama, Masanori, Suzuki, Yutaka, Miyoshi, Hironao, Yamamoto, Satoshi, Takeyama, Yosifumi, Nakano, Eriko, Takuma, Kensuke, Sakagami, Junichi, Hayashi, Kazuki, Kogure, Atsuko, Ito, Tetsuya, Mukai, Tsuyoshi, Maetani, Iruru, Nagahama, Masatsugu, Serikawa, Masahiro, Ueki, Toshiharu, Furuya, Ken, Isayama, Hiroyuki, Moriyama, Ichiro, Shigeno, Masaya, Mizukami, Kazuhiro, Nanashima, Atsushi, Oana, Shuhei, Ikehata, Atsushi, Watanabe, Noriko, Hirooka, Yoshiki, Ogoshi, Keiichiro, Sasaki, Yoji, Iwata, Yoshinori, Kudo, Yasushi, Nakayama, Ataru, and Nakamura, Masafumi

Published
2018
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42. Time to think prime times for treatment of necrotizing pancreatitis: Pendulum conundrum.

Author

Nakai, Yousuke, Hamada, Tsuyoshi, Saito, Tomotaka, Shiomi, Hideyuki, Maruta, Akinori, Iwashita, Takuji, Iwata, Keisuke, Takenaka, Mamoru, Masuda, Atsuhiro, Matsubara, Saburo, Sato, Tatsuya, Mukai, Tsuyoshi, Yasuda, Ichiro, Isayama, Hiroyuki, Nakano, Ryota, Ota, Shogo, Yoshida, Kensaku, Tezuka, Ryuichi, Akihiko, Senju, and Uemura, Shinya

Subjects
NECROTIZING pancreatitis, PENDULUMS, TREATMENT effectiveness, ENDOSCOPIC ultrasonography, RHINORRHEA
Abstract

Pancreatic fluid collections (PFCs) typically develop as local complications of acute pancreatitis and complicate the clinical course of patients with acute pancreatitis and potentially fatal clinical outcomes. Interventions are required in cases of symptomatic walled‐off necrosis (WON) (matured PFCs with necrosis) and pancreatic pseudocysts (matured PFCs without necrosis). In the management of necrotizing pancreatitis and WON, endoscopic ultrasound‐guided transluminal drainage combined with on‐demand endoscopic necrosectomy (i.e. the step‐up approach) is increasingly used as a less invasive treatment modality compared with a surgical or percutaneous approach. Through the substantial research efforts and development of specific devices and stents (e.g. lumen‐apposing metal stents), endoscopic techniques of PFC management have been standardized to some extent. However, there has been no consensus about timing of carrying out each treatment step; for instance, it is uncertain when direct endoscopic necrosectomy should be initiated and finished and when a plastic or metal stent should be removed following clinical treatment success. Despite emerging evidence for the effectiveness of noninterventional supportive treatment (e.g. antibiotics, nutritional support, irrigation of the cavity), there has been only limited data on the timing of starting and stopping the treatment. Large studies are required to optimize the timing of those treatment options and improve clinical outcomes of patients with PFCs. In this review, we summarize the current available evidence on the indications and timing of interventional and supportive treatment modalities for this patient population and discussed clinical unmet needs that should be addressed in future research. [ABSTRACT FROM AUTHOR]

Published
2023
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43. WONDER-01: immediate necrosectomy vs. drainage-oriented step-up approach after endoscopic ultrasound-guided drainage of walled-off necrosis—study protocol for a multicentre randomised controlled trial

Author

Sato, Tatsuya, primary, Saito, Tomotaka, additional, Takenaka, Mamoru, additional, Iwashita, Takuji, additional, Shiomi, Hideyuki, additional, Fujisawa, Toshio, additional, Hayashi, Nobuhiko, additional, Iwata, Keisuke, additional, Maruta, Akinori, additional, Mukai, Tsuyoshi, additional, Masuda, Atsuhiro, additional, Matsubara, Saburo, additional, Hamada, Tsuyoshi, additional, Inoue, Tadahisa, additional, Ohyama, Hiroshi, additional, Kuwatani, Masaki, additional, Kamada, Hideki, additional, Hashimoto, Shinichi, additional, Shiratori, Toshiyasu, additional, Yamada, Reiko, additional, Kogure, Hirofumi, additional, Ogura, Takeshi, additional, Nakahara, Kazunari, additional, Doi, Shinpei, additional, Chinen, Kenji, additional, Isayama, Hiroyuki, additional, Yasuda, Ichiro, additional, and Nakai, Yousuke, additional

Published
2023
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45. Endoscopic ultrasound-guided fine-needle biopsy of solid pancreatic tumors with 3 versus 12 to-and-fro movements: A multicenter prospective randomized controlled study

Author

Takahashi, Kosuke, primary, Yasuda, Ichiro, additional, Hayashi, Nobuhiko, additional, Iwashita, Takuji, additional, Okuno, Mitsuru, additional, Mukai, Tsuyoshi, additional, Mabuchi, Masatoshi, additional, Adachi, Seiji, additional, Doi, Shinpei, additional, Imura, Johji, additional, Ozawa, Eisuke, additional, Miyaaki, Hisamitsu, additional, and Nakao, Kazuhiko, additional

Published
2023
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47. Supportive treatment during the periprocedural period of endoscopic treatment for pancreatic fluid collections: a critical review of current knowledge and future perspectives

Author

Iwashita, Takuji, primary, Iwata, Keisuke, additional, Hamada, Tsuyoshi, additional, Saito, Tomotaka, additional, Shiomi, Hideyuki, additional, Takenaka, Mamoru, additional, Maruta, Akinori, additional, Uemura, Shinya, additional, Masuda, Atsuhiro, additional, Matsubara, Saburo, additional, Mukai, Tsuyoshi, additional, Takahashi, Sho, additional, Hayashi, Nobuhiko, additional, Isayama, Hiroyuki, additional, Yasuda, Ichiro, additional, and Nakai, Yousuke, additional

Published
2022
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48. The effect of ursodeoxycholic acid following self-expandable metallic stent placement in malignant distal biliary obstruction: A propensity score-matched cohort analysis

Author

Okuno, Mitsuru, primary, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Ohashi, Yosuke, additional, Iwata, Shota, additional, Iwasa, Yuhei, additional, Yoshida, Kensaku, additional, Maruta, Akinori, additional, Tezuka, Ryuichi, additional, Ichikawa, Hironao, additional, Mita, Naoki, additional, Uemura, Shinya, additional, Iwashita, Takuji, additional, Tomita, Eiichi, additional, and Shimizu, Masahito, additional

Published
2022
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49. Early versus delayed interventions for necrotizing pancreatitis: A systematic review and meta‐analysis

Author

Nakai, Yousuke, primary, Shiomi, Hideyuki, additional, Hamada, Tsuyoshi, additional, Ota, Shogo, additional, Takenaka, Mamoru, additional, Iwashita, Takuji, additional, Sato, Tatsuya, additional, Saito, Tomotaka, additional, Masuda, Atsuhiro, additional, Matsubara, Saburo, additional, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Isayama, Hiroyuki, additional, and Yasuda, Ichiro, additional

Published
2022
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