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Modular integrated construction (MiC) is an innovative construction method that is widely used in practice, but high transportation cost is an obstacle to its wider implementation. This paper is motivated by the real-world need for a scientific approach for MiC transport scheduling, and addresses the practical problem of how to achieve on-time door-to-door MiC delivery in an economical manner. An innovative integer programming model is formulated with the objective of minimising the total transportation costs, including trailer rental, fuel costs, and worker salaries. A case study based on Hong Kong data validates that the developed model can be efficiently solved for problems of practical size. The results also demonstrate that the derived MiC schedule plan can reduce transportation costs by 58.7% compared with a just-in-time (JIT) strategy, thus bringing great economic benefits to off-site construction practitioners. Useful managerial implications related to on-site MiC storage areas are derived through sensitivity analysis. Overall, this paper sets the ground for the application of mathematical programming methodology to the off-site construction field. Future research may be devoted to MiC transport scheduling under uncertainty. [ABSTRACT FROM AUTHOR]

Stimuli-responsive luminescent materials can be used to design anti-counterfeit barcodes because even small changes in environmental conditions, such as temperature or the molecules present, can lead to changes in the fluorescence behavior of the materials, enabling dynamic information encoding. Metal–organic frameworks (MOFs) are promising materials for the design of stimuli-responsive barcodes, as their modular structure allows fine tuning of the fluorescence, which in turn can be switched in response to external stimuli. In this work, we present a humidity-responsive fluorescent barcode prototype based on europium- and cobalt-modified MOF-808, which exhibits fluorescence switching in response to changes in relative humidity. The combination of cobalt and europium cations in the same material, along with the coordination ligands on the cobalt cations, are crucial for the functionality of this barcode. By selectively suppressing the fluorescence of europium through the absorption of cobalt complexes in the same energy range, the initial fluorescence intensity of the material can be adjusted. The additional coordination of water molecules to the cobalt centers leads to the formation of cobalt complexes with higher ligand field splitting energy, resulting in a stepwise reactivation of the emission of the europium cations. This can be readily accomplished by exposing the material to different relative humidities. As a result, the barcode provides a higher level of security, as its decoding must be performed under controlled atmospheric conditions, and it is user-friendly since no harmful chemicals are required during the reading process. Additionally, the initial state must be restored before each decoding by heating, as the fluorescence changes dynamically according to the environmental conditions. These characteristics of the material underline the anti-counterfeiting capabilities of the barcode. [ABSTRACT FROM AUTHOR]

Recent advances in neural engineering have opened new ways to investigate the impact of topology on neural network function. Leveraging microfluidic technologies, it is possible to establish modular circuit motifs that promote both segregation and integration of information processing in the engineered neural networks, similar to those observed in vivo. However, the impact of the underlying topologies on network dynamics and response to pathological perturbation remains largely unresolved. In this work, we demonstrate the utilization of microfluidic platforms with 12 interconnected nodes to structure modular, cortical engineered neural networks. By implementing geometrical constraints inspired by a Tesla valve within the connecting microtunnels, we additionally exert control over the direction of axonal outgrowth between the nodes. Interfacing these platforms with nanoporous microelectrode arrays reveals that the resulting laminar cortical networks exhibit pronounced segregated and integrated functional dynamics across layers, mirroring key elements of the feedforward, hierarchical information processing observed in the neocortex. The multi-nodal configuration also facilitates selective perturbation of individual nodes within the networks. To illustrate this, we induced hypoxia, a key factor in the pathogenesis of various neurological disorders, in well-connected nodes within the networks. Our findings demonstrate that such perturbations induce ablation of information flow across the hypoxic node, while enabling the study of plasticity and information processing adaptations in neighboring nodes and neural communication pathways. In summary, our presented model system recapitulates fundamental attributes of the microcircuit organization of neocortical neural networks, rendering it highly pertinent for preclinical neuroscience research. This model system holds promise for yielding new insights into the development, topological organization, and neuroplasticity mechanisms of the neocortex across the micro- and mesoscale level, in both healthy and pathological conditions. [ABSTRACT FROM AUTHOR]

To improve the fault-tolerant ability of switched reluctance motor (SRM) drive systems and ensure the braking performance of the electric vehicle driven by in-wheel SRMs, a novel fault-tolerant control method that includes the open circuit and the short circuit is presented in this study. First, a novel modular fault-tolerant power converter, which includes traditional driving topology and modular fault-tolerant construction, is built in accordance with the traditional half-bridge power converter. This novel converter provides an advanced fault-tolerant solution for the faults of SRM drive systems. Then, combined with the corresponding detection signals, a new fault detection method is presented for accurately detecting the faults of the system. Furthermore, a new fault-tolerant control method is proposed to improve the fault-tolerant ability of the system. Notably, the fault-tolerant process is completed by employing the circuit of the traditional power converter to replace the fault circuit of the modular construct when faults are detected. Moreover, simulation results are obtained and compared. The results indicate that the proposed method can ensure vehicle braking performance, including braking comfort, braking safety, endurance mileage, and braking stability. Finally, hardware-in-the-loop is conducted, and the results demonstrate the real-time performance and validity of the proposed method. [ABSTRACT FROM AUTHOR]

Accumulating evidence have documented sex differences in brain anatomy from early childhood to late adulthood. However, whether sex difference of brain structure emerges in the neonatal brain and how sex modulates the development of cortical morphology during the perinatal stage remains unclear. Here, we utilized T2-weighted MRI from the Developing Human Connectome Project (dHCP) database, consisting of 41 male and 40 female neonates born between 35 and 43 postmenstrual weeks (PMW). Neonates of each sex were arranged in a continuous ascending order of age to capture the progressive changes in cortical thickness and curvature throughout the developmental continuum. The maturational covariance network (MCN) was defined as the coupled developmental fluctuations of morphology measures between cortical regions. We constructed MCNs based on the two features, respectively, to illustrate their developmental interdependencies, and then compared the network topology between sexes. Our results showed that cortical structural development exhibited a localized pattern in both males and females, with no significant sex differences in the developmental trajectory of cortical morphology, overall organization, nodal importance, and modular structure of the MCN. Furthermore, by merging male and female neonates into a unified cohort, we identified evident dependencies influences in structural development between different brain modules using the Granger causality analysis (GCA), emanating from high-order regions toward primary cortices. Our findings demonstrate that the maturational pattern of cortical morphology may not differ between sexes during the perinatal period, and provide evidence for the developmental causality among cortical structures in perinatal brains. [ABSTRACT FROM AUTHOR]

The challenge of implementing industrialized construction to achieve sustainable future-proof healthcare facilities is not only about construction methods themselves but also about how to shift design methodologies. COVID-19 has raised the attention of research and practices in using modular design and construction for healthcare facilities. However, the lifespan and functional differences between general and emergency healthcare facilities mean that their sustainable design requirements are not exactly the same. Drawing from 27 interviews and design review sessions with 19 international groups of experts, this research proposes a modular adaptable hospital design (MAHD) approach based on the Open Building Concept (OBC). This includes an evaluation framework composed of five design categories and 23 subcategories complemented with a set of design guidelines and it concludes by identifying a future implementation pathway. This research extends the implementation of OBC through theoretical contributions for modular and adaptable designs and practical guidelines for future design implementation. [ABSTRACT FROM AUTHOR]

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Modular integrated construction (MiC) becomes a promising solution to improve production efficiency in the construction industry. However, the off‐site production and on‐site installation processes of MiC pose challenges to collaboration efficiency among the multiple stakeholders involved, including subcontractors, contractors, and consumers. These challenges stem from information dispersion, which impedes effective collaboration and communication. Such problems can be solved by introducing a blockchain‐based cyber‐physical service platform, which can facilitate information sharing and collaboration across the supply chain. In this paper, we study the impacts of MiC and blockchain technology on construction supply chains and reveal several important insights. First, we find that there exists a first‐mover advantage in the traditional construction supply chain, where subcontractors engage in a sequential game, and the subcontractor who produces first obtains more profit than the counterparts. Moreover, the contractor's ability to increase profits by reducing the unit cost of construction time is limited, but it can improve the effectiveness of the time gap due to early delivery. Second, we show that MiC should not be introduced if it significantly reduces collaboration efficiency in the supply chain. Interestingly, increasing the unit cost of construction for subcontractors can actually result in greater profits for all members of the supply chain. Regarding adopting blockchain technology, our findings suggest that supply chain members generally hold similar attitudes. Specifically, when the value of blockchain in improving collaboration efficiency is below a certain threshold, its adoption may not be beneficial, despite its potential to enable rapid production and early delivery. [ABSTRACT FROM AUTHOR]

Translation abstract Material‐saving concrete ceiling made from 3D‐printed interlocking blocksA new modular design principle has the potential to revolutionize concrete construction: the concept of topological interlocking of building blocks. The innovative arrangement of these interlocking blocks effectively prevents kinematic loading of individual blocks by the entire assembly by immobilising each other. This study investigates the synergy between topological interlocking and 3D concrete printing and conducts a comprehensive analysis of the manufacturing processes and structural performance. The interlocking blocks, which interlock without binders, offer outstanding prospects for sustainable construction. The study presents a method for optimising block geometries for 3D printing to ensure interlocking integrity. Three specific block geometries are developed and tested for 3D concrete printing. Different methods are used to produce interlocking blocks in 3D concrete printing. A geometry is selected and tested on both a small and large scale in the form of a plate system. This is followed by experimental tests, including precise 3D photogrammetry measurements, to evaluate the structural behaviour of these plate systems. The results impressively demonstrate the feasibility and enormous potential of integrating topological interlocking and 3D concrete printing for sustainable construction applications. [ABSTRACT FROM AUTHOR]

Electrochemical reactors, powered by renewable electricity, have garnered widespread attention for chemical synthesis due to their low energy consumption and pollution‐free features. However, the inherent design flaw of traditional electrochemical reactors has persistently hindered the advancement of electrochemical synthesis, as they result in low product concentrations, low purity, and continuous production issues. As a novel electrochemical reactor, the porous solid‐state electrolyte (PSE) reactor is elaborately designed to overcome the limitation by enabling the direct and continuous synthesis of pure products, possessing a modular and scalable structure with high efficiency, safety, and long stability. In this work, first, the distinctive design of the PSE reactor, highlighting its structural features, core components, and variable configurations, is introduced. Furthermore, the configuration‐relevant applications in electrosynthesis, such as formic acid, acetic acid, and hydrogen peroxide (H2O2) production, are summarized. Integrated applications are also discussed, along with potential domains for improvements and optimization. Finally, the future developmental directions of the PSE devices are thoroughly explored. By addressing its unique design attributes, showcasing its capabilities, and envisioning prospective refinements and diverse applications, the aim is to boost the progression of this transformative technology toward widespread commercialization and industrial adoption, thereby revolutionizing sustainable electrochemical synthesis. [ABSTRACT FROM AUTHOR]

The loss of a single chromosome in a diploid organism halves the dosage of many genes and is usually accompanied by a substantial decrease in fitness. We asked whether this decrease simply reflects the joint damage caused by individual gene dosage deficiencies. We measured the fitness effects of single heterozygous gene deletions in yeast and combined them for each chromosome. This predicted a negative growth rate, that is, lethality, for multiple monosomies. However, monosomic strains remained alive and grew as if much (often most) of the damage caused by single mutations had disappeared, revealing an exceptionally large and positive epistatic component of fitness. We looked for functional explanations by analyzing the transcriptomes. There was no evidence of increased (compensatory) gene expression on the monosomic chromosomes. Nor were there signs of the cellular stress response that would be expected if monosomy led to protein destabilization and thus cytotoxicity. Instead, all monosomic strains showed extensive upregulation of genes encoding ribosomal proteins, but in an indiscriminate manner that did not correspond to their altered dosage. This response did not restore the stoichiometry required for efficient biosynthesis, which probably became growth limiting, making all other mutation- induced metabolic defects much less important. In general, the modular structure of the cell leads to an effective fragmentation of the total mutational load. Defects outside the module(s) currently defining fitness lose at least some of their relevance, producing the epiphenomenon of positive interactions between individually negative effects. [ABSTRACT FROM AUTHOR]

Dithieno[3,2‐b:2',3'‐d]thiophene (DTT) derivative contains three annulated thiophene rings, which have attracted great attention in the field of materials due to its planar and conjugated molecular, structural rigidity, and increased solubility. Herein, the one‐step modular construction of a series of structurally well‐defined 2,6‐disubstituted dithieno[3,2‐b:2',3'‐d]thiophenes (2,6‐DTT) involves Pd/Cu(I)‐catalyzed Sonogashira coupling and LiNH2‐mediated ring‐closing reaction with element sulfur was reported. The method allows the selective and straightforward introduction of different aryl substitution into DTT without otherwise tedious separation and purification processes. The preliminary study of the thermal and photophysical properties demonstrated that the introduction of substituent in phenyl has great impact for the parent molecule, which enable this protocol to synthesis high‐performance 2,6‐DTT through the different alkynes. [ABSTRACT FROM AUTHOR]

Adaptor proteins play central roles in the assembly of molecular complexes and coordinated activation of specific pathways. Through their modular domain structure, the NCK family of adaptor proteins (NCK1 and NCK2) link protein targets via their single SRC Homology (SH) 2 and three SH3 domains. Classically, their SH2 domain binds to phosphotyrosine motif-containing receptors (e.g. receptor tyrosine kinases), while their SH3 domains bind polyproline motif-containing cytoplasmic effectors. Due to these functions being established for both NCK1 and NCK2, their roles were inaccurately assumed to be redundant. However, in contrast with this previously held view, NCK1 and NCK2 now have a growing list of paralog-specific functions, which underscores the need to further explore their differences. Here we review current evidence detailing how these two paralogs are unique, including differences in their gene/protein regulation, binding partners and overall contributions to cellular functions. To help explain these contrasting characteristics, we then discuss SH2/SH3 structural features, disordered interdomain linker regions and post-translational modifications. Together, this review seeks to highlight the importance of distinguishing NCK1 and NCK2 in research and to pave the way for investigations into the origins of their interaction specificity. [ABSTRACT FROM AUTHOR]

Translation abstract Influence of rapid heat treatment on the short‐term creep of high‐strength concreteAssembly of modular load‐bearing structures requires high precision geometry of precast concrete parts. Besides the manufacturing tolerances, transient, material‐related deviations due to shrinkage and creep must be taken into account. Regarding deformations [1] has already shown that rapid heat treatment significantly reduces shrinkage in high‐performance concretes. In this paper, the influence of heat treatment on creep deformation will be investigated. The focus is on short‐term creep within the first 28 days after concreting in order to mimic early construction stages experimentally. Heat treatment immediately after concreting in durations of 2, 4 and 24 h at 80 °C and 60 % RH as well as samples without heat treatment for reference are investigated. Loading starts 48 hours after concreting to cover minimum times between production and assembly. The experiments are performed on cylinders (D/H=100/200 mm) at load levels of 20 and 40 % of the early concrete strength. It is shown that heat treatment effectively reduces creep strains by up to 66 % (24 h) or 21 % (2 h), depending on the duration. Despite the high initial strength of the concrete, non‐linear creep is observed. The test results are generalized for different durations of heat treatment and load levels and processed into functional relationships by polynomial response surfaces. [ABSTRACT FROM AUTHOR]

Translation abstract Erection of modularised shell structures with prestressed dry jointsThe exponential growth of concrete production in recent decades has led to a high raw material consumption and a large amount of CO2 emissions. To minimise the use of resources, material‐efficient structures such as shell structures, which are adapted to the distribution of forces, can be used as a basis. However, due to their curved geometry, these structures involve a complex construction process. Modular construction with industrially prefabricated concrete components can contribute to more efficient production and construction processes, combining the advantages of prefabrication with the benefits of material‐efficient load‐bearing structures. This article presents a concept for the modularisation of simply curved shell structures and demonstrates a method for the rapid erection of curved structures with prefabricated individual precast elements and prestressed dry joints. The feasibility is demonstrated by experimental investigations. [ABSTRACT FROM AUTHOR]

Acridine frameworks stand as pivotal architectural elements in pharmaceuticals and photocatalytic applications, owing to their chemical adaptability, biological activity, and unique excited‐state dynamics. Conventional synthetic routes often entail specialized starting materials, anaerobic or moisture‐free conditions, and elaborate multi‐stage manipulations for incorporating diverse functionalities. Herein, we present a convergent approach integrating photo‐excitation of readily available ortho‐alkyl nitroarenes with copper‐promoted cascade annulation. This innovative system enables an aerobic, one‐pot reaction of o‐alkyl nitroarenes with arylboronic acids, thereby streamlining the modular construction of a wide array of acridine derivatives with various functional groups. This encompasses symmetrical, unsymmetrical and polysubstituted varieties, some of which are otherwise exceptionally difficult to synthesize. Furthermore, it significantly improves the production of structurally varied acridinium salts, featuring enhanced photophysical properties, high excited state potentials (E*red=2.08–3.15 V), and exhibiting superior performance in intricate photoredox transformations. [ABSTRACT FROM AUTHOR]

In this article we study combinatorial non-positive curvature aspects of various simplicial complexes with natural A ˜ n shaped simplices, including Euclidean buildings of type A ˜ n and Cayley graphs of Garside groups and their quotients by the Garside elements. All these examples fit into the more general setting of lattices with order-increasing Z -actions and the associated lattice quotients proposed in a previous work by the first named author. We show that both the lattice quotients and the lattices themselves give rise to weakly modular graphs, which is a form of combinatorial non-positive curvature. We also show that several other objects fit into this setting of lattices/lattice quotients, including Artin complexes of Artin-Tits groups of type A ˜ n , a class of arc complexes and weak Garside groups arising from a categorical Garside structure in the sense of Bessis. Hence our result also implies to these objects and shows that they give weakly modular graphs. Along the way, we also clarify the relationship between categorical Garside structures, lattices with Z action and different classes of complexes studied this article. We use this point of view to describe the first examples of Garside groups with exotic properties, like non-linearity or rigidity results. [ABSTRACT FROM AUTHOR]

This paper presents the experimental validation of a connections system to connect segmented precast long‐span thin‐shell structures made with lightweight ultra‐high‐performance fiber‐reinforced concrete (UHPFRC). The work comprises the segmentation of the large‐span ultra‐thin shell to meet the requirements of prefabrication (construction and transport limitations), and the design and characterization of the connections. Once the assembling of the shell required the use of post‐tensioned unbonded prestressing, an indented dry connection was chosen. The connections are experimentally characterized with in‐plane and out‐of‐plane shear tests for different prestressing levels. The results are presented and discussed, demonstrating the balanced behavior of the indented dry connection under shear loading. The connections exhibited high ductility in shear, capitalizing on the use of a UHPFRC to fabricate the shell. The prestressing also demonstrated its efficacy, significantly enhancing both the stiffness and the capacity of the indented dry connection. [ABSTRACT FROM AUTHOR]

Errors in stimulus estimation reveal how stimulus representation changes during cognitive processes. Repulsive bias and minimum variance observed near cardinal axes are well- known error patterns typically associated with visual orientation perception. Recent experiments suggest that these errors continuously evolve during working memory, posing a challenge that neither static sensory models nor traditional memory models can address. Here, we demonstrate that these evolving errors, maintaining characteristic shapes, require network interaction between two distinct modules. Each module fulfills efficient sensory encoding and memory maintenance, which cannot be achieved simultaneously in a single- module network. The sensory module exhibits heterogeneous tuning with strong inhibitory modulation reflecting natural orientation statistics. While the memory module, operating alone, supports homogeneous representation via continuous attractor dynamics, the fully connected network forms discrete attractors with moderate drift speed and nonuniform diffusion processes. Together, our work underscores the significance of sensory- memory interaction in continuously shaping stimulus representation during working memory. [ABSTRACT FROM AUTHOR]

Social media may have an impact on people’s interaction patterns and social relationships. Investigating the interaction patterns of learners across various social media platforms can provide profound insights into the characteristics and mechanisms of connectivist learning. This study explores interaction network characteristics and the dynamic evolution of interaction patterns across multiple social media platforms within a cMOOC by using SNA and SIENA. The results show that cMOOC learners' interaction patterns have evolved with different characteristics on WeChat, blogs, and forums, eventually forming distinct interaction networks on each platform. The interaction networks on WeChat demonstrate superior performance in terms of size, cohesion, and connectivity, followed by the networks on blogs, and lastly, those on forums. WeChat and blog interaction networks exhibit a multi-center structure and modular characteristics, while forum interaction networks display a single-center structure. The evolution of interaction patterns on WeChat reveals more significant effects, such as reciprocity, transitivity, homophily, and preferential attachment, in contrast to blogs and forums, where transitivity and homophily are not prominent. The paper concludes with a discussion on the interaction patterns and network characteristics supported by three types of social media. Additionally, it highlights the significance and implications of these findings for educational practice. [ABSTRACT FROM AUTHOR]

Mineralized hydrogels have attracted significant attention in the field of bone repair. Herein, an innovative strategy of "freezing, salting‐out and mineralizing" (FSM) is proposed for the construction of mineralized hydrogels. Based on this strategy, a collagen/hydroxyapatite (HA) mineralized hydrogel is synthesized as the template of mineralized hydrogels, and the critical roles of freezing and salting‐out in the formation of hydrogels are demonstrated. Comparative analyses with collagen/HA mineralized hydrogels synthesized through two other traditional methods reveal that the hydrogel constructed by FSM exhibits satisfactory operation simplicity, mineralization degree, uniformity distribution, mechanical property, degradation stability, cytocompatibility, and osteogenic property, indicating that it can serve as an ideal mineralized hydrogel scaffold for bone repair. Furthermore, 16 other kinds of mineralized hydrogels with different systems are constructed by modularly expanding the raw materials used in the FSM process to nine common biomedical polymers, four metal cations and three anions, confirming the universality of the proposed FSM strategy for most mineralized hydrogel. Overall, the three‐step FSM strategy, which integrates the salting‐out effect with mineralization, represents a groundbreaking approach for the fabrication of mineralized hydrogels, offering a simple, universal and modular method for their construction. [ABSTRACT FROM AUTHOR]

Targeted protein degradation (TPD) has emerged as a revolutionary paradigm in drug discovery and development, offering a promising avenue to tackle challenging therapeutic targets. Unlike traditional drug discovery approaches that focus on inhibiting protein function, TPD aims to eliminate proteins of interest (POIs) using modular chimeric structures. This is achieved through the utilization of proteolysis-targeting chimeras (PROTACs), which redirect POIs to E3 ubiquitin ligases, rendering them for degradation by the cellular ubiquitin–proteasome system (UPS). Additionally, other TPD technologies such as lysosome-targeting chimeras (LYTACs) and autophagy-based protein degraders facilitate the transportation of proteins to endo-lysosomal or autophagy-lysosomal pathways for degradation, respectively. Despite significant growth in preclinical TPD research, many chimeras fail to progress beyond this stage in the drug development. Various factors contribute to the limited success of TPD agents, including a significant hurdle of inadequate delivery to the target site. Integrating TPD into delivery platforms could surmount the challenges of in vivo applications of TPD strategies by reshaping their pharmacokinetics and pharmacodynamic profiles. These proteolysis-targeting drug delivery systems (ProDDSs) exhibit superior delivery performance, enhanced targetability, and reduced off-tissue side effects. In this review, we will survey the latest progress in TPD-inspired drug delivery systems, highlight the importance of introducing delivery ideas or technologies to the development of protein degraders, outline design principles of protein degrader-inspired delivery systems, discuss the current challenges, and provide an outlook on future opportunities in this field. [ABSTRACT FROM AUTHOR]

The relevance of the subject matter is conditioned by the high-efficiency use of reconfigurable manufacturing systems during construction work and the associated need to develop and implement technological machines with replaceable working bodies. The purpose of this study is to analyze the invariance of the equipment used by types of work in landscape and landscape construction. The study used theoretical methods of analysis and synthesis of information on the principles of the practical application of a universal machine with a wide range of mounted technological working bodies. The results obtained indicate the high relevance of the issue of the rapid changeability of mounted technological working bodies. Its effective solution lies in the creation of reconfigurable production machines based on a universal wheelbase with replaceable working bodies of variable layout by type of work, for which a new design of an inter-module basing and fastening device is proposed. The possibility of its practical application in the BobCat loader system is considered. It is established that, in general, the use of the BobTach mounting frame during various technological operations ensures an increase in the efficiency of this technological equipment. In addition, it significantly increases the performance of the entire model range of equipment and testifies to the versatility of the specified mounting frame. The practical significance of the results obtained is conditioned by the possibility of their application in the development and implementation of modern technological machines with rapidly replaceable working bodies in the agricultural sector and road construction. [ABSTRACT FROM AUTHOR]

Modular construction (MC) is an innovative approach to enhancing productivity and sustainability, but its complex and dynamic supply chain is challenging. This paper develops and validates a dialectical system framework for understanding and enhancing the MC supply chain, through the combination of a literature review, interviews with 59 professionals and a case study of modular integrated construction development in Hong Kong, China. The developed framework encompasses seven key components of the MC supply chain technical system – namely, pre-approval, building plan pre-submission, detailed design, module production, logistics, module installation, and quality assurance and quality control – considering various stakeholders embedded in broader contexts. The case study validates the framework as a theoretical lens to comprehend the complex MC supply chain and as a novel analytical model to enhance the MC supply chain from different stakeholder and contextual perspectives. Future research directions are suggested regarding strategy establishment, performance measurement and policy road map development to achieve a mature and sustainable supply chain. [ABSTRACT FROM AUTHOR]

In this paper we study the modular structure of the Foulkes module H (2 m) of the symmetric group S 2 m acting on set partitions of a set of size 2m into m sets each of size 2, defined over a field of positive characteristic p. We aim to understand the decomposition of the tensor powers of H (2 m) . In particular, we study the asymptotics of the non-projective part of tensor powers of these modules by computing the gamma invariant as defined by Dave Benson and Peter Symonds. [ABSTRACT FROM AUTHOR]

This research addresses energy consumption challenges in the design and construction of concrete freeform surface architecture. It proposes an integrated design approach centered on smooth poly-hypar surfaces, serving as a mediator to amalgamate architectural smoothness, structural stiffness, construction convenience, and building energy efficiency from the initial design phase. To testify the versatile functionality of smooth poly-hypar surfaces beyond structural loadbearing, they are employed in the design and construction of a Solar house—a prototype aimed at establishing an energy-efficient modular design and construction system for concrete-freeform surface buildings. This approach capitalizes on the unique structural and geometrical properties offered by smooth poly-hypar surfaces. By leveraging this special geometry, the methodology transcends individual stages, encompassing the entire integrated process and overcoming limitations associated with traditional sequential design strategies. It underscores the interconnected nature of design, construction, and sustainability considerations. [ABSTRACT FROM AUTHOR]

Optimization of tower crane positioning is essential in precast building construction to ensure that a crane is in the right position to offer the best value for placing precast elements. The first goal is the optimization of transportation distances made by tower cranes, which will address the issues of efficiency and cost. This is done in a way that provides for minimization of the distances that lie between the trailer parking where elements are parked, the tower crane, and the construction installation point. However, current research fails to address the dynamic movement efficiency of trailers, especially when handling multiple trailers and several models of tower cranes, making this scenario an optimization problem that is classified as NP-hard due to the likelihood of causing a combinatorial explosion. This work endeavors to present a new mathematical model that has been applied to the Genetic Algorithm (GA). The ideal demand-generated model is designed to solve the optimal model and position of tower cranes and the prospective positioning of trailers for parking. The feasibility and applicability of the method exploited in the study are also established through a project case study. When adopting the proposed planning model compared to the earlier planning scale, comparisons highlight a small yet significant saving of 6% in time and cost when lifting elements instead of providing them from the trailers by setting up a new on-site stockyard. In addition, a great deal of enhancement is also observed in the final solution aspects, where the developed GA has even reduced the operational time and cost by half a percent each. The results of this research offer best-practice approaches to the position analysis of tower cranes in precast building construction to bring scalability and cost optimization to bear on the construction business. [ABSTRACT FROM AUTHOR]

To ensure the fire resistance performance of modular construction, various methods such as spray-applied fire resistive material (SFRM), intumescent paint, and gypsum board can be used. Rectangular steel tube columns, commonly used in modular construction units, are fireproofed by attaching fireproofing boards. The required thickness of the fireproof board increases with the duration of fire exposure, which in turn increases the self-weight. To address these issues, this study proposes two conditions for improving fire resistance: (1) SFRM application, and (2) mortar filling or finishing on both the inside and outside of small-sized rectangular steel tube columns in modular units. Experimental and analytical approaches were employed to evaluate the behavior of these columns over time under fire exposure and to analyze the required sheathing thickness according to the fire-resistant sheathing method. The results indicated that mortar filling suppressed the temperature rise due to its thermal storage effect. The application of fireproofing spray after mortar filling extended the fire resistance time by approximately 143 to 146% compared to the unfilled specimen. It was also found that SFRM provided a 149% higher fireproofing performance compared to finishing mortar. [ABSTRACT FROM AUTHOR]

This manuscript critically evaluates the potential of modular construction as a viable remedy to the ongoing housing crisis in the UK. In light of the escalating construction costs and the long-standing lack of productivity gains in the residential construction sector, there is in fact an urgent need to explore innovative solutions to address the scarcity of affordable housing. The study delves then into the feasibility and effectiveness of modular construction in providing cost-efficient and sustainable housing alternatives, particularly for the working-class population. Through a comprehensive analysis of construction trends and methodologies, and stakeholder perspectives, this research aims to illuminate the advantages and limitations of modular construction compared to traditional building techniques. Drawing upon data sourced from construction professionals, and government records, the study assesses crucial factors such as construction timelines, financial implications, design adaptability, and overall efficacy in tackling the housing crisis. The findings of this study are poised to offer valuable insights into the potential role of modular construction in transforming housing solutions in the UK. By examining the intersection of housing demand, construction practices, and technological advancements, the manuscript seeks to inform decision-making processes in both public and private sectors. Ultimately, the objective is to identify strategies that can facilitate the widespread adoption of modular construction as a sustainable and scalable solution to the housing crisis, in line also with the principles of the circular economy, thereby enhancing access to safe, affordable, and high-quality housing for all segments of society. [ABSTRACT FROM AUTHOR]

Programmable matter refers to material that can be programmed to alter its physical properties, including its shape. Such matter can be built as a lattice of attached robotic modules, each seen as an autonomous agent with communication and motion capabilities. Self-reconfiguration consists in changing the initial arrangement of modules to form a desired goal shape, and is known to be a complex problem due to its algorithmic complexity and motion constraints. In this paper, we propose to use a max-flow algorithm as a centralized global planner to determine the concurrent paths to be traversed by modules through a porous structure composed of 3D Catoms meta-modules with the aim of increasing the parallelism of motions, and hence decreasing the self-reconfiguration time. We implement a traffic light system as a distributed asynchronous local planning algorithm to control the motions to avoid collisions. We evaluated our algorithm using VisibleSim simulator on different self-reconfiguration scenarios and compared the performance with an existing fully distributed synchronous self-reconfiguration algorithm for similar structures. The results show that the new method provides a significant gain in self-reconfiguration time and energy efficiency. [ABSTRACT FROM AUTHOR]

Decentralized applications (DApps) built on blockchain platforms such as Ethereum and coded in languages such as Solidity, have recently gained attention for their potential to disrupt traditional centralized systems. Despite their rapid adoption, limited research has been conducted to understand the underlying code structure of these applications. In particular, each DApp is composed of multiple smart contracts, each containing a number of functions that can be called to trigger a specific event, e.g., a token transfer. In this paper, we reconstruct and analyse the network of contracts and functions calls within the DApp, which is helpful to unveil vulnerabilities that can be exploited by malicious attackers. We show how decentralization is architecturally implemented, identifying common development patterns and anomalies that could influence the system's robustness and efficiency. We find a consistent network structure characterized by modular, self-sufficient contracts and a complex web of function interactions, indicating common coding practices across the blockchain community. Critically, a small number of key functions within each DApp play a central role in maintaining network connectivity, making them potential targets for cyber attacks and highlighting the need for robust security measures. [ABSTRACT FROM AUTHOR]

Translation abstract Additive flow production of lightweight precision concrete elementsIn modern flow production, the focus is on the continuously digitally controlled tools in the context of the digital twin. Spray extrusion, especially when combined with a thin layer of shotcrete and ribbed support structures, e. g. for façade elements, results in highly efficient components with high load‐bearing capacity and high‐quality surfaces. The developed combined spray extrusion nozzle offers the possibility of both spraying and extrusion, adaption of mortar and concrete. In addition, the automated integration of anchors is the focus of flow production, for which anchors and tooling systems have been developed. Based on the determination of characteristic values, the practicability and the increase in productivity will be proven. This data will form the basis of a digital twin, in preparation for Industry 4.0. This increase in productivity in additive manufacturing leads to positive economic effects. Applications of high‐strength lightweight structures in the construction industry are becoming more attractive and enable the serial implementation of free‐form modular constructions. [ABSTRACT FROM AUTHOR]

The modular structure of functional connectomes in the human brain undergoes substantial reorganization during development. However, previous studies have implicitly assumed that each region participates in one single module, ignoring the potential spatial overlap between modules. How the overlapping functional modules develop and whether this development is related to gray and white matter features remain unknown. Using longitudinal multimodal structural, functional, and diffusion MRI data from 305 children (aged 6 to 14 years), we investigated the maturation of overlapping modules of functional networks and further revealed their structural associations. An edge-centric network model was used to identify the overlapping modules, and the nodal overlap in module affiliations was quantified using the entropy measure. We showed a regionally heterogeneous spatial topography of the overlapping extent of brain nodes in module affiliations in children, with higher entropy (i.e., more module involvement) in the ventral attention, somatomotor, and subcortical regions and lower entropy (i.e., less module involvement) in the visual and default-mode regions. The overlapping modules developed in a linear, spatially dissociable manner, with decreased entropy (i.e., decreased module involvement) in the dorsomedial prefrontal cortex, ventral prefrontal cortex, and putamen and increased entropy (i.e., increased module involvement) in the parietal lobules and lateral prefrontal cortex. The overlapping modular patterns captured individual brain maturity as characterized by chronological age and were predicted by integrating gray matter morphology and white matter microstructural properties. Our findings highlight the maturation of overlapping functional modules and their structural substrates, thereby advancing our understanding of the principles of connectome development. [ABSTRACT FROM AUTHOR]

Type-A γ-aminobutyric acid (GABAA) receptors are channel proteins crucial to mediating neuronal balance in the central nervous system (CNS). The structure of GABAA receptors allows for multiple binding sites and is key to drug development. Yet the formation mechanism of the receptor's distinctive pentameric structure is still unknown. This study aims to investigate the role of three predominant subunits of the human GABAA receptor in the formation of protein pentamers. Through purifying and refolding the protein fragments of the GABAA receptor α1, β2, and γ2 subunits, the particle structures were visualised with negative staining electron microscopy (EM). To aid the analysis, AlphaFold2 was used to compare the structures. Results show that α1 and β2 subunit fragments successfully formed homo-oligomers, particularly homopentameric structures, while the predominant heteropentameric GABAA receptor was also replicated through the combination of the three subunits. However, homopentameric structures were not observed with the γ2 subunit proteins. A comparison of the AlphaFold2 predictions and the previously obtained cryo-EM structures presents new insights into the subunits' modular structure and polymerization status. By performing experimental and computational studies, a deeper understanding of the complex structure of GABAA receptors is provided. Hopefully, this study can pave the way to developing novel therapeutics for neuropsychiatric diseases. [ABSTRACT FROM AUTHOR]

In recent years, network science has received significant attention and application. As an important mesoscale structure of networks, community structure reveals the inherent modular structure and potential functionality of networks. Therefore, maintaining the community structure during attacks is crucial. Existing studies on community robustness primarily focus on two attack behaviors: malicious attacks and random failures. However, little is known on the community robustness in the more practical situations where the attackers have limited ability to access precise network information, leading to gray information attack behaviors. Hence, in this paper, we investigate the robustness of network communities under gray information attacks and the enhancing algorithms. Following the community robustness measure for the sequential attacks, we establish a unified evaluation framework for attacks with gray information by introducing a gray attack coefficient, which treats the usual random failures and malicious attacks as the two special situations in the proposed framework. Several enhancing algorithms with local search strategy are exquisitely devised. The efficacy of our framework and algorithms which significantly improve the community robustness against gray attacks is demonstrated by the experimental results on a variety of real-world networks. Our findings have important implications not only in enhancing the community robustness of existing networks but also in designing robust ones from the scratch, which paves the way to further understand and seek strategies and solutions for network community robustness with gray information. [ABSTRACT FROM AUTHOR]

The aim of this paper is to transfer the restrictedness theory to Hom-Lie algebras. The concept of restricted Hom-Lie algebras, which is introduced in [S. Bouarroudj and A. Makhlouf, Hom-lie superalgebras in characteristic 2, Mathematics 11 2023, 24, Paper No. 4955], will be used in this paper. First, the existence and uniqueness of p-structures on a Hom-Lie algebra is studied. Then the definition of a restrictable Hom-Lie algebra is given and the equivalence relation between restrictable Hom-Lie algebras and restricted Hom-Lie algebras is constructed. Finally, the p-envelopes of a Hom-Lie algebra are defined and studied. [ABSTRACT FROM AUTHOR]

Incorporating AC-type flying capacitors (FC) between series-connected devices is an effective way to enhance the rated voltage for high-power applications based on current source converters (CSCs). Through appropriate modulation and FC voltage control, it is possible to achieve improved DC bus voltage quality with reduced common-mode voltage (CMV) and low dv/dt. On the other hand, the parallel CSC is a popular choice for increasing the system's rated current to accommodate higher power applications. The use of interleaved modulation techniques can improve the harmonic performance of parallel converters while reducing the need for passive filters. The modular flying capacitor clamped (FCC)-CSC structure can combine these advantages, achieving higher rated power along with improved power quality on both the DC and AC sides. Moreover, the enhanced AC quality contributes to the regulation of FC voltage and further improves the DC-side voltage quality. This paper analyzes the operation principle of the parallel FCC-CSC structure and proposes an interleaved space vector modulation (SVM) method to enhance the harmonic performance of the AC output. Additionally, an optimized zero-state replacement (ZSR) based FC voltage control and a DC-link current balance strategy built on this control are introduced. Simulation and experimental results validate the effectiveness of the proposed methods. [ABSTRACT FROM AUTHOR]

In order to study the influence of modular filled and composite material forms on the axial crushing and energy absorption properties of structures, modular filled composite structures were constructed, and innovatively applied to the inner side of double-hat beam (DHB) structures in automobiles. The modular filled structures comprise hexagonal, quadrilateral, and triangular sections. By analyzing the collision performance of modular filled DHB structures, significant enhancements were observed in both the sectional characteristics and the specific Mean Crushing Force of modular filled DHBs compared to the conventional double-hat beam structure. These advancements notably improved the plastic deformation characteristics of the structures. Additionally, dynamic weightlessness experiments were conducted to validate the accuracy of the simulation model. Among the proposed schemes, namely QU-5, HE-5, and TR-5, notable improvements in crashworthiness were identified. Specifically, crashworthiness indicators increased by 32.54%, 78.9%, and 116.53%. Compared with other thin-walled structures, modular filled composite DHBs have advantages in axial crushing and energy absorption. By optimizing layout characteristics, the modular filled structures will achieve significant lightweight and energy absorption performance improvements. This work has clear reference value for automotive engineers and scholars to further explore the axial crash safety, platform modularization, and lightweight design of vehicles. [ABSTRACT FROM AUTHOR]

Precast construction offers multiple benefits, encompassing heightened productivity, an enhanced working environment, and significant waste reduction. Timely delivery of precast components (PCs) is of paramount importance in the successful execution of construction projects, mainly because processes involving precast prefabrication are identified frequently as critical activities in the majority of cases. However, current scheduling models for precast production need to meet the demands of dynamic environments in which construction projects contend with uncertainties. Consequently, it is essential to investigate and develop more-resilient and flexible scheduling approaches to address these challenges effectively and guarantee the timely delivery of precast components in these dynamic construction scenarios. To address these challenges, this study introduces an approach that integrates precast tracking, positioning, progress monitoring, and analysis among the multiple stages undertaken by project communities. Each component's status is updated dynamically in the cloud-based Building Information Modeling (BIM) platform using radio-frequency identification (RFID) and ultrawideband (UWB) technologies. Moreover, the collected data are updated to a dynamic production planning engine to be analyzed more accurately and flexibly for prefabrication, fitting-out, installation resources, workerpower planning, scheduling, and execution. To verify the efficiency of the proposed system, on-site testing was performed on a prefabricated prefinished volumetric construction (PPVC) residential building project. The findings show that a precast component can be tracked precisely on-site and that the sensor network can deliver trustworthy data. This research adopted an innovative and comprehensive methodology, centering on the transmission of real-time data collected via RFID and UWB sensing to enable dynamic scheduling in precast construction. By facilitating dynamic planning, scheduling, optimization, and progress monitoring, the study introduces a paradigm shift in construction project management, markedly improving the efficiency and effectiveness of project execution. Practical Applications: Precast construction, known for its efficiency and sustainability, faces a key challenge in ensuring the timely delivery of precast components. This is crucial because PCs assembly often represents critical activities in construction projects. Current scheduling engines struggle to adapt to the unpredictable nature of construction environments, which frequently deal with uncertainties. This study presents an innovative approach that integrates tracking, positioning, and progress monitoring of PCs using advanced technologies. By employing radio-frequency identification and ultrawideband sensors, PCs' status is updated in real-time on a cloud-based Building Information Modeling platform. These data are uploaded into a dynamic production scheduling engine, enhancing the accuracy and flexibility of scheduling and execution, especially for prefabrication and installation stages. This approach was tested in a real-world prefabricated prefinished volumetric construction residential building project. The results demonstrate the system's ability to locate PCs on-site precisely and provide reliable data. This holistic strategy not only allows for dynamic scheduling, optimizing workerpower and resource allocation, but also enhances overall project management. This leads to more-effective planning, optimization, and monitoring of progress, significantly improving project execution in precast construction environments. [ABSTRACT FROM AUTHOR]

Tower crane layout planning (TCLP) is key to ensure the safety and productivity of construction projects. Previous studies on TCLP mainly focused on the typical in situ construction method, however, overlooking modular integrated construction (MiC). This study aims to develop an integrated planning approach for optimizing the locations of tower cranes and trucks for MiC across the entire construction site. This approach consists of four objective components. First, identifying potential locations for cranes and trucks by adopting a gridding method and an intersection examination algorithm. Second, estimating the crane operation duration. Third, optimizing the crane and truck locations by developing an integer linear programming (ILP) model while considering various constraints, such as the demand fulfillment, the crane's lifting capacity, and the multiple truck parking areas. Lastly, optimizing the distance between cranes to avoid crane blocking on site. The proposed approach is validated via three high-rise residential MiC projects. The results achieve 19.4%–37.9% reductions in cranes' operation durations, as well as carbon emissions from the original plan. Compared with another existing TCLP method made from limited predefined layout plans, a 29.4% improvement is observed. Moreover, three aspects to extend the application of the approach are discussed: (1) the multiple tower crane layout scenario, (2) the impact of the number of truck points, and (3) the trade-offs between computing effectiveness and performance. The approach realizes the objective of TCLP decision-making for multi-crane multitruck MiC throughout the whole construction site. Construction practitioners can use this approach for decision-making which helps enhance the effectiveness of their tower crane layout designs. [ABSTRACT FROM AUTHOR]

Let N ≥ 3 and r ≥ 1 be integers and p ≥ 2 be a prime such that p ∤ N. One can consider two different integral structures on the space of modular forms over Q , one coming from arithmetic via q -expansions, the other coming from geometry via integral models of modular curves. Both structures are stable under the Hecke operators; furthermore, their quotient is finite torsion. Our goal is to investigate the exponent of the annihilator of the quotient. We will apply methods due to Brian Conrad to the situation of modular forms of even weight and level Γ (N p r) over Q p (ζ N p r ) to obtain an upper bound for the exponent. We also use Klein forms to construct explicit modular forms of level p r whenever p r > 3 , allowing us to compute a lower bound which agrees with the upper bound. Hence we compute the exponent precisely. [ABSTRACT FROM AUTHOR]

Designing a fully modular building, which is without the support of any separate lateral resisting elements, has the advantage of rapid site assembly, but runs the risk of a brittle style of connection failures in a rare earthquake event. Thus, this form of construction is currently limited to low-rise buildings. Isolating the building from its base and allowing the rocking motion to occur has been proven to be effective in dissipating energy and prolonging the natural periods by the lifting of the structure, thereby alleviating high strength demand on the building itself. To avert overturning, the amount of the rotation of the building needs to be controlled, and the use of superelastic tendons as a restraint is a promising solution. Previous studies into the seismic performance with this novel form of construction have been limited to experimenting with a rigid block or a single lumped mass system. In this study, this approach of seismic isolation is extended to a high-rise modular building with distributed mass and stiffness. A scaled-down model of a 19-story fully modular building, which was partially restrained by superelastic tendons, was tested on a shaking table. The key objective was to study the deflection profile and distribution of internal forces up the height of the superelastic tendon–restrained building and examine the contributions by the higher modes. The internal forces predicted by the analytical model developed in the study are shown to be in good agreement with experimental measurements. Practical Applications: Modular construction shortens construction time and reduces environmental impacts. Currently, fully modular buildings, which have a high degree of prefabrication, are limited to low-rise constructions because of concerns over the overturning risk in major earthquake events. A new seismic safe design employing a superelastic tendon is introduced in this article to extend fully modular construction to high-rise buildings. The building is designed to rotate about its base when subjected to high intensity ground shaking. The amount of rotation is controlled by the superelastic tendon in order to avoid overturning from occurring. Meanwhile, internal forces taken up by the structural elements within the building were kept much lower than a conventional fixed base building. The dynamic testing of the miniature model of a 19-story building on the shaking table was featured in the study, which laid down principles that are essential for the formulation of effective guidelines for the structural design of this type of building. [ABSTRACT FROM AUTHOR]

Artificial reefs featuring different shapes and functions have been deployed around the world, causing impacts on marine ecosystems. However, the approaches typically used to deliver topological complexity, flexibility and expanding requirements to prospective structures during the initial design stages are not well established. The aim of this study was to highlight the advantages and provide evidence on how modularity and parametric design can holistically leverage the performance of multifunctional artificial reefs (MFARs). In particular, the goal was to develop a parametric design for MFAR and establish a direct relationship between specific design parameters and the MFAR target functions or design requirements. The idea of implementing the parametric design for generating the initial biomimetic geometry of the individual modular unit was explored. Furthermore, possible ways of manipulating the geometric parameters of the individual module and the whole assembly were proposed. The findings suggest that, by adopting the developed procedure and the examples studied, several functions may be reached within a single assembly: the promotion of marine biodiversity restoration, the support of scientific platforms with various sensors, as well as the development of recreational diving and of touristic attraction areas. Acquired knowledge suggests that the concept of a nature-like design approach was developed for artificial reefs with varying scales, complexity and functions, which widens the range of possibilities of how smart design of human-made underwater structures may contribute to benefiting the near shore ecosystems. [ABSTRACT FROM AUTHOR]

In high-power applications, achieving adequate power quality in power converter design is accomplished by utilizing multilevel inverters instead of using two-level and three-level inverters. The device generates a sinusoidal output voltage, which results in reduced total harmonic distortion and lower voltage stress on the switches and leads to lower electromagnetic interference, making it suitable for use in renewable energy applications. However, to illustrate the advantages mentioned above, a significant number of switching devices and DC sources are necessary while raising the voltage levels. This article proposes an asymmetrical voltage generation method, which operates in a ratio of 1:5 and generates 25 levels using 11 power switches. The topology is modular in structure, and each module has a lower component count, which significantly reduces the overall cost. The proposed topology is capable of generating negative output voltage levels without the use of an H-bridge configuration, where only three switches are used to generate any voltage levels. The functionality of the developed module is amended by fixing different voltage values in DC sources. This article also presents a comprehensive examination of the circuit and the functioning of various voltage levels. The advantages of the proposed inverter have been demonstrated by comparative research with the currently existing MLI topologies. Ultimately, both the simulation and experimental findings validated the practical capabilities. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to identify and assess the barriers to implementing modular construction systems (MCS) in developing country's architecture, engineering and construction (AEC) industry, targeting built environment professionals from Nigeria and South Africa. Design/methodology/approach: The study adopted a quantitative research method, using a structured questionnaire to seek the opinions of the professionals on the identified categories of barriers. Findings: Results indicated that all identified categories of barriers were statistically significant using a one-sample t-test at p = 0.05 significance level which indicates they are critical towards the implementation of MCS in developing countries. Assessment of the opinion of the professionals using the Kruskal–Wallis scale showed that they hold similar views on the barriers to the adoption of MCS. Pearson correlation shows a high correlation coefficient amongst the barrier categories and an acceptable level of significance (p = 0.05). Research limitations/implications: This study is limited to two significant African countries (Nigeria and South Africa) selected based on the gross domestic product (GDP). Further studies can consider developing countries outside Africa and investigate broader respondents. Practical implications: The study provides implications on the barriers affecting MCS in developing countries for the academia, industry and government to have an insight into the barriers and make informed decisions and policies. Originality/value: The research satisfies the need to study the barriers affecting the MCS in developing countries that can mitigate housing deficits. This innovative construction method has been adopted and implemented in developed countries, and the result has been positive. [ABSTRACT FROM AUTHOR]

Relearning to walk requires progressive training in real scenarios—overground—along with assistance in basic tasks, such as balancing. In addition, user ability must be maximized through compliant robotic assistance as needed. Despite decades of research, gait rehabilitation robotic devices yield controversial results. This article presents the conceptual design of a novel walking assistance and rehabilitation robot, the NIMBLE robot, aimed at providing ambulatory, bodyweight-supported gait training, assisting the user's center of mass trajectory to aid weight transfer and dynamic balance during walking. NIMBLE consists of a robotic mobile frame, a partial bodyweight support (PBWS) system, an ambulatory lower-limb exoskeleton (Exo-H3) and a cable-driven pelvis-assisting robot. Designed as a modular structure, it differentiates hierarchical communication levels through a Robot Operating System (ROS) 2 network. We present the mechatronic design and experimental results assessing the impact of the mechatronic coupling between the robotic modules on the walking kinematics and the frame movement control performance. The robotic frame hardly affects the walking kinematics up to 2 degrees in both the sagittal and frontal planes, making it feasible for lateral balance and weight translation training. Moreover, it successfully tracks and follows user trajectories. The NIMBLE robotic frame assessment shows promising results for ambulatory gait rehabilitation. [ABSTRACT FROM AUTHOR]

Though refugee camps are by definition "temporary", many camps endure for decades, where individuals live full lives through childhood, marriage, children, grandchildren, and death. These settlements function no differently than cities in their social life, density, zoning, and operation, yet are "planned" through UNHCR (United Nations High Commissioner for Refugees) templates for camps. The Zaatari camp in Jordan for Syrian asylum seekers, for example, holds a population of 80,000. Rather than viewing refugee camps as temporary human warehouses, this article demonstrates that camps are spaces where individuals build social networks and economic activities flourish. As such, the camp planning templates should include adaptive Construction 4.0 technologies for more socially flexible settlements, even if the camps are considered "temporary". This case study research on the Zaatari camp illustrates how refugees adapt their built environment, identifying adaptation patterns that enhance both livability and sustainability. The work illustrates social and environmental changes that require adaptive housing configurations. The conclusion suggests linking modern tools in the construction industry to empirically derived planning objectives to be efficiently executed in moments of crisis. [ABSTRACT FROM AUTHOR]

An offshore multipurpose floating platform (MPFP) combines different marine technologies to serve industry needs using one infrastructure; the aim of an MPFP is enlarging the synthesis benefits and reducing the negative impacts. Ocean thermal energy conversion (OTEC) in particular has attracted significant attention for its great potential and low environmental risk. This research demonstrates the system design of a conceptual MPFP in the South China Sea, evaluating its economic and environmental sustainability using an inclusive index. The system is based on a modular floating structure with a designed lifetime of 50 years. Tuna aquaculture, microalgae cultivation and processing, and the OTEC energy infrastructure are integrated to increase the profitability of the applications. We adopted a high-yield photobioreactor microalgae cultivation system and a low-cost barge-type floating structure combined with a semisubmergible to reduce the required area and cost of the floating structure and improve the sustainability of the system. The inclusive impact index "Triple-I-light (IIIlight)" was calculated to evaluate the environmental sustainability and economic feasibility of the floating system. The result shows that the new system becomes environmentally neutral (EF = BC) at a lifetime of 11.5 years, showing sustainability (IIIlight ≤ 0) at a lifetime of 20 years. The proposed system can produce fish with no external energy or feed supply. An autonomous system, such as the one proposed here, is considered very effective when it comes to utilizing the ocean and contributing to a sustainable society. [ABSTRACT FROM AUTHOR]

The study aims to identify and categorise the deterrents to adopting modular construction (MC) in affordable housing (AH), revealing their interconnections, and proposing strategies to overcome them. A systematic literature review (SLR) was conducted, followed by Pareto analysis and total interpretive structural modelling (TISM). A total of 75 deterrents were identified from 46 studies, spanning 7 categories: environmental, social and cultural, technical and construction, industry and market, administrative and bureaucratic, economic, and regulatory and policy. The top deterrent category was found to be economic, specifically high initial investment costs and financing challenges. Significant deterrents, particularly economic ones, that impede the adoption of MC in AH are revealed. The interconnectedness of these deterrents highlights the need for comprehensive strategies addressing multiple categories simultaneously. Mitigation strategies and countermeasures are proposed to facilitate the adoption of MC. The study is based on the existing literature, which may have limitations in terms of capturing all possible deterrents. Further empirical research is needed to validate and expand upon these findings. A critical gap is filled by this study, which systematically categorises and analyses deterrents to MC in AH and proposes actionable strategies to mitigate them, thereby contributing to more effective and widespread adoption of MC. The findings are valuable to both global audiences and Australian stakeholders and provide insights that allow the barriers to MC in AH to be overcome. [ABSTRACT FROM AUTHOR]

Chemotherapy drugs often cause various adverse reactions and affect normal tissues, so it is of great significance to design effective targeted anti‐tumor drug delivery methods. We constructed a series of self‐assembled supramolecular modular structures and explored whether they could become an effective targeted antitumor fluorescent agent. UV and fluorescence spectra show that it has fluorescence. The drug release curve was determined by dialysis method and the results showed that the release rate of PCB series composites was the highest under pH = 5. The curcumin pyrimidine derivative was embedded in the structure, and the formation of the complex was confirmed by infrared spectroscopy. The results for the cell imaging indicated that with the decrease of environmental pH value, the ability of PCB‐1 and PCB‐2 to penetrate the biofilm barrier into cells increased, suggesting that they have targeting action. The results of the cell viability test showed that PCB‐1 and PCB‐2 had a good inhibitory effect on MGC and HeLa cells. TEM showed that PCB‐1 was a regular hexahedron structure and PCB‐2 was a rod structure. In addition, the encapsulation efficiency of PCB‐1 and PCB‐2 was tested to be 86.50% and 88.57%, respectively, with drug loading rates of 27.62% and 28.38%, and Zeta potential values of +35 and +32. In conclusion, PCB‐1 and PCB‐2 are good potential anti‐tumor fluorescent agents. [ABSTRACT FROM AUTHOR]