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Your search keyword '"Mikołajewska H"' showing total 11 results
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11 results on '"Mikołajewska H"'

1. [Trends in the search for new compounds with potential anti- trichomonal and anti-fungal effects].

Author

Kotełko B, Guryn R, and Mikołajewska H

Subjects
Animals, Antifungal Agents chemistry, Antitrichomonal Agents chemistry, Candida growth & development, Culture Media, Drug Evaluation, Preclinical, Econazole chemistry, In Vitro Techniques, Miconazole chemistry, Trichomonas growth & development, Antifungal Agents pharmacology, Antitrichomonal Agents pharmacology, Candida drug effects, Econazole pharmacology, Miconazole pharmacology, Trichomonas drug effects
Published
1990

2. [Estimated number of expected stochastic changes in the population occupationally exposed to X-rays].

Author

Swiderski P, Mikołajewska H, and Jankowski J

Subjects
Dose-Response Relationship, Radiation, Female, Humans, Male, Poland, Stochastic Processes, Neoplasms, Radiation-Induced epidemiology, Occupational Diseases epidemiology, Radiation Injuries epidemiology
Abstract

In this paper the life-time effective dose equivalent and expected postradiation stochastic effects number in various subpopulations occupationally exposed to X-rays have been estimated. The prognosis of life-time doses absorbed by those occupationally exposed to X-rays and the relationship between the effective dose equivalent and surface exposure dose registered in the individual dosimetry system constituted the basis for this evaluation. The obtained results indicate that under the present X-ray exposure conditions the probability of the occurrence of X-ray adverse health effects in form of post-radiation cancers is insignificantly low.

Published
1987

3. [Synthesis and pharmacological properties of new 4-chlorophenoxyacetic acid derivatives].

Author

Szadowska A, Mazur M, Graczyk J, Kiełek MB, Guryn R, Mikołajewska H, Glinka R, and Kotełko B

Subjects
2,4-Dichlorophenoxyacetic Acid chemical synthesis, 2,4-Dichlorophenoxyacetic Acid pharmacology, Animals, Antihypertensive Agents, Blood Pressure drug effects, Body Temperature drug effects, Chemical Phenomena, Chemistry, Depression, Chemical, Guinea Pigs, Humans, Ileum drug effects, Mice, Mice, Inbred BALB C, Motor Activity drug effects, Muscle, Smooth drug effects, Rabbits, Rats, Rats, Inbred Strains, Sleep drug effects, Stereotyped Behavior drug effects, Tranquilizing Agents, 2,4-Dichlorophenoxyacetic Acid analogs & derivatives
Published
1982

4. [Effective and exposure doses in persons occupationally exposed to x-ray radiation].

Author

Mikołajewska H and Jankowski J

Subjects
Humans, Occupational Diseases prevention & control, Occupational Medicine, Radiation Injuries prevention & control, Radiation Monitoring methods
Abstract

Individual dosimetry of doses received by persons working with radiation is made by film badges which are worn by workers at the chest. These dosimeters measured the exposure at the body surface, but it is well known that the real risk of ionizing radiation is due to the doses absorbed by radiosensitive organs and so called "effective dose equivalent". In the paper the results showing the relationship between the exposure and effective dose equivalent are presented vs x-radiation energy. In the case when the phantom was irradiated from the front the effective dose equivalent was only 40% of exposure. When the phantom was irradiated from the back the effective dose equivalent was 70% higher than the exposure from the film badge.

Published
1983

5. [The search for antiparasitic and antifungal agents. III. Synthesis of 2-(piperazinyl)-, (perhydroazepinyl)- and (perhydro-1,4-diazepinyl)-ethyl-chlorobenzene ethers with potential antiparasitic action].

Author

Majchrzak M, Mikołajewska H, Krakowiak K, Sikorska R, and Kotełko B

Subjects
Animals, Antinematodal Agents pharmacology, Azepines pharmacology, Chemical Phenomena, Chemistry, Chlorobenzenes chemical synthesis, Chlorobenzenes pharmacology, Drug Evaluation, Preclinical, Ethyl Ethers chemical synthesis, Mice, Nematoda drug effects, Piperazines pharmacology, Antinematodal Agents chemical synthesis, Azepines chemical synthesis, Oligochaeta drug effects, Piperazines chemical synthesis
Published
1981

7. New derivatives of hexahydroazepine, hexahydro(1,4,5)oxadiazepine and hexahydro(1,4,5)oxadiazocine with expected pharmacological activity.

Author

Glinka R, Kotełko B, Mikołajewska H, and Mikiciuk-Olasik E

Subjects
Animals, Azepines pharmacology, Azepines toxicity, Azocines pharmacology, Azocines toxicity, Chemical Phenomena, Chemistry, Drug Interactions, Lethal Dose 50, Levodopa pharmacology, Mice, Motor Activity drug effects, Seizures physiopathology, Sleep drug effects, Azepines chemical synthesis, Azocines chemical synthesis
Abstract

New derivatives with the expected pharmacological activity of heterocyclic systems mentioned above having ether (1-6) and ester (7-10) groups were obtained.

Published
1979

8. [Synthesis of derivatives of perhydroazepine, perhydro-1,5-oxazocine, morpholine and piperazine containing 3-(isopropylamino)-propan-2-ol group--compounds with potential effect on the circulatory system and central nervous system].

Author

Kotełko B, Mikołajewska H, Glinka R, and Guryn R

Subjects
Azepines chemical synthesis, Humans, Morpholines chemical synthesis, Oxazocines chemical synthesis, Piperazine, Piperazines chemical synthesis, Azepines pharmacology, Blood Circulation drug effects, Central Nervous System drug effects, Morpholines pharmacology, Oxazocines pharmacology, Piperazines pharmacology
Published
1985

9. Investigations of anthelminthic activity and synthesis of new derivatives of perhydroazepine, perhydro-1,4-diazepine, perhydro-1,4-oxazepine and perhydro-1,5-oxazocine.

Author

Glinka R, Grzywacz M, Kotełko B, Majchrzak M, Malinowski H, Mikołajewska H, Mikiciukolasik E, and Szkukliński J

Subjects
Animals, Anthelmintics pharmacology, Anthelmintics toxicity, Mice, Nematode Infections drug therapy, Anthelmintics chemical synthesis, Azepines chemical synthesis, Oxazocines chemical synthesis
Abstract

Anthelminthic activity of new esters of 3,4,5-trimethoxybenzoic acid containing rests of the title heterocyclic amines has been determined. 3-(Perhydroazepinyl)-propyl ester 6 acts on enchytraeids in vitro 56-fold stronger than piperazine adipate, 2-(perhydroazepinyl)-ethyl ester 5 is the most effective in a therapy of mice infested with nematodes.

Published
1980

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