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2. P658: COMPARISON OF CHARACTERISTICS AND OUTCOME OF COVID-19 INFECTION IN PATIENTS WITH LYMPHOPROLIFERATIVE DISEASE AND IN PATIENTS FROM THE GENERAL POPULATION - EXPERIENCE FROM THREE UNIVERSITY CENTERS

Author

Markovic, O., primary, Divac, A., additional, Cvetkovic, Z., additional, Stanisavljevic, D., additional, Markovic, K., additional, Bukurecki, I., additional, Bibic, T., additional, Stanisavljevic, N., additional, Bila, J., additional, and Zdravkovic, M., additional

Published
2022
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5. Corrigendum to 'Non-indigenous macrozoobenthic species on hard substrata of selected harbours in the Adriatic Sea' (Marine Pollution Bulletin (2019) 147 (150–158), (S0025326X17310585), (10.1016/j.marpolbul.2017.12.031))

Author

Spagnolo A., Auriemma R., Bacci T., Balkovic I., Bertasi F., Bolognini L., Cabrini M., Cilenti L., Cuicchi C., Cvitkovic I., Despalatovic M., Grati F., Grossi L., Jaklin A., Lipej L., Markovic O., Mavric B., Mikac B., Nasi F., Nerlovic V., Pelosi S., Penna M., Petovic S., Punzo E., Santucci A., Scirocco T., Strafella P., Trabucco B., Travizi A., Zuljevic A., Spagnolo A., Auriemma R., Bacci T., Balkovic I., Bertasi F., Bolognini L., Cabrini M., Cilenti L., Cuicchi C., Cvitkovic I., Despalatovic M., Grati F., Grossi L., Jaklin A., Lipej L., Markovic O., Mavric B., Mikac B., Nasi F., Nerlovic V., Pelosi S., Penna M., Petovic S., Punzo E., Santucci A., Scirocco T., Strafella P., Trabucco B., Travizi A., and Zuljevic A.

Subjects
Erratum
Abstract

No abstract available

Published
2021

6. Cervical acid phosphatase detection: A guide to abnormal cells in cytology smear screening for cervical cancer

Author

Deb Prabal, Iyer Venkateswaran, Bhatla Neerja, Markovic O, and Verma Kusum

Subjects
Cervical cancer, cytology, cervical acid phosphatase, screening., Cytology, QH573-671
Abstract

Background: Cervical acid phosphatase-Papanicolaou (CAP-PAP) test has recently been described for detection of acid phosphatase enzyme in abnormal squamous cells, and has been proposed as a biomarker-based technology for the screening of cervical cancer. Materials and Methods: Eighty-one consecutive cervical smears were subjected to routine Papanicolaou (Pap) staining as well as CAP-PAP, which combined cytochemical staining for acid phosphatase with modified Pap stain. Statistical evaluation of its utility was examined. Results: Of 81 smears, 16 (19.75%) showed the presence of mature squamous cells with acid phosphatase by CAP-PAP technique and were considered positive. Of these 16, atypical squamous cells of undetermined significance (ASCUS) or above were initially diagnosed in five of the corresponding routine Pap smears. After re-evaluation with CAP-PAP, eight of the routine Pap smears were considered to have ASCUS or above. Of these eight, three were reported as low-grade squamous intraepithelial lesions and five as ASCUS on conventional Pap smears. The remaining 8/16 CAP-PAP-positive cases were negative for atypical squamous cells on the corresponding Pap smears. None of the CAP-PAP-negative smears were positive on routine Pap smear screening. Conclusions: This study highlights the efficacy of CAP-PAP in quality assurance of cervical smear screening. It is also an inexpensive method for segregating smears for subsequent re-screening. In the absence of trained cytologists in peripheral laboratories, this technique can be adopted for identifying smears that would require proper evaluation.

Published
2008

7. Corrigendum to “Non-indigenous macrozoobenthic species on hard substrata of selected harbours in the Adriatic Sea” [Mar. Pollut. Bull. 147 (2019); 150–158]

Author

Spagnolo, A., Auriemma, R., Bacci, T., Balković, I., Bertasi, F., Bolognini, L., Cabrini, M., Cilenti, L., Cuicchi, C., Cvitković, I., Despalatović, M., Grati, F., Grossi, L., Jaklin, A., Lipej, L., Marković, O., Mavrič, B., Mikac, B., Nasi, F., Nerlović, V., Pelosi, S., Penna, M., Petović, S., Punzo, E., Santucci, A., Scirocco, T., Strafella, P., Trabucco, B., Travizi, A., and Žuljević, A.

Published
2021
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14. Spatiotemporal abundance pattern of deep-water rose shrimp, Parapenaeus longirostris, and Norway lobster, Nephrops norvegicus, in European Mediterranean waters

Author

Sbrana, M. (Mario), Zupa, W., Ligas, A. (Alessandro), Capezzuto, F., Chatzispyrou, A., Follesa, M.C. (Maria Cristina), Gancitano, Vita, Guijarro, B. (Beatriz), Jadaud, A. (Angélique), Markovic, O., Micallef, R. (Reno), Peristeraki, P. (Panagiota), Piccinetti, C., Thasitis, I. (Ioannis), and Carbonara, P.

Subjects
Nephrops norvegicus, Centro Oceanográfico de Baleares, Mediterranean Sea, distribution, Pesquerías, trawl survey, Parapenaeus longirostris
Abstract

The main characteristics concerning the distribution of two of the most important decapod crustaceans of commercial interest in the Mediterranean Sea, the deep-water rose shrimp, Parapenaeus longirostris, and the Norway lobster, Nephrops norvegicus, are studied in the European Mediterranean waters. The study is based on data collected under the MEDITS trawl surveys from 1994 to 2015 from the Gibraltar Straits to the northeastern Levantine Basin (Cyprus waters). The observed differences can be interpreted as different responses to environmental drivers related to the differing life history traits of the two species. In fact, N. norvegicus is a long-living, benthic burrowing species with low growth and mortality rates, while P. longirostris is an epibenthic, short-living species characterized by higher rates of growth and mortality., Sí

Published
2019

16. Spatial and temporal patterns in the Mediterranean populations of Aristaeomorpha foliacea and Aristeus antennatus (Crustacea: Decapoda: Aristeidae) based on the MEDITS surveys

Author

Guijarro, Beatriz, Bitetto, Isabella, D'onghia, G., Follesa, Maria Cristina, Kapiris, K., Mannini, Alessandro, Markovic, O., Micallef, Reno, Ragonese, Sergio, Skarvelis, K., Cau, A., Guijarro, Beatriz, Bitetto, Isabella, D'onghia, G., Follesa, Maria Cristina, Kapiris, K., Mannini, Alessandro, Markovic, O., Micallef, Reno, Ragonese, Sergio, Skarvelis, K., and Cau, A.

Abstract

The aristeids Aristaeomorpha foliacea and Aristeus antennatus are two species of great economic importance in the Mediterranean Sea, where they are exploited almost exclusively by bottom trawlers. We analysed their geographical and inter-annual patterns using data collected, following a standardized protocol, during the MEDITS international experimental bottom trawl surveys. The data used consisted of standardized abundance and biomass indices, size structure and individual biological information collected in the northern Mediterranean for more than two decades. Several univariate and multivari-ate methodologies were used to analyse the data. The current study confirms previous findings, such as the longitudinal gra-dient in the relative presence of the aristeids, but also offers additional information for a better understanding of the intrinsic variability of the data over the years and between areas. Moreover, geographical variability in the somatic condition index is discussed, taking into account the role of environmental conditions and fishing pressure. The large geographical variability found for both species in this regional approach reflects the importance of additional studies at a small-scale geographical level. Such studies could be particularly important for managing and ensuring the stability of these species, for which large regional approaches may be inadequate

Published
2019

17. Spatiotemporal abundance pattern of deep-water rose shrimp, Parapenaeus longirostris, and Norway lobster, Nephrops norvegicus, in European Mediterranean waters

Author

Sbrana, Mario, Zupa, W., Ligas, Alessandro, Capezzuto, F., Chatzispyrou, A., Follesa, Maria Cristina, Gancitano, Vita, Guijarro, Beatriz, Jadaud, Angélique, Markovic, O., Micallef, Reno, Peristeraki, Panagiota, Piccinetti, C., Thasitis, Ioannis, Carbonara, P., Sbrana, Mario, Zupa, W., Ligas, Alessandro, Capezzuto, F., Chatzispyrou, A., Follesa, Maria Cristina, Gancitano, Vita, Guijarro, Beatriz, Jadaud, Angélique, Markovic, O., Micallef, Reno, Peristeraki, Panagiota, Piccinetti, C., Thasitis, Ioannis, and Carbonara, P.

Abstract

The main characteristics concerning the distribution of two of the most important decapod crustaceans of commercial interest in the Mediterranean Sea, the deep-water rose shrimp, Parapenaeus longirostris, and the Norway lobster, Nephrops norvegicus, are studied in the European Mediterranean waters. The study is based on data collected under the MEDITS trawl surveys from 1994 to 2015 from the Gibraltar Straits to the northeastern Levantine Basin (Cyprus waters). The observed differences can be interpreted as different responses to environmental drivers related to the differing life history traits of the two species. In fact, N. norvegicus is a long-living, benthic burrowing species with low growth and mortality rates, while P. longirostris is an epibenthic, short-living species characterized by higher rates of growth and mortality.

Published
2019

18. Cardiopoietic cell therapy for advanced ischemic heart failure : results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Author

Bartunek, Jozef, Terzic, Andre, Davison, Beth A, Filippatos, Gerasimos S, Radovanovic, Slavica, Beleslin, Branko, Merkely, Bela, Musialek, Piotr, Wojakowski, Wojciech, Andreka, Peter, Horvath, Ivan G, Katz, Amos, Dolatabadi, Dariouch, El Nakadi, Badih, Arandjelovic, Aleksandra, Edes, Istvan, Seferovic, Petar M, Obradovic, Slobodan, Vanderheyden, Marc, Jagic, Nikola, Petrov, Ivo, Atar, Shaul, Halabi, Majdi, Gelev, Valeri L, Shochat, Michael K, Kasprzak, Jaroslaw D, Sanz Ruiz, Ricardo, Heyndrickx, Guy R, Nyolczas, Noémi, Legrand, Victor, Guédès, Antoine, Heyse, Alex, Moccetti, Tiziano, Fernandez Aviles, Francisco, Jimenez Quevedo, Pilar, Bayes Genis, Antoni, Hernandez Garcia, Jose Maria, Ribichini, Flavio, Gruchala, Marcin, Waldman, Scott A, Teerlink, John R, Gersh, Bernard J, Povsic, Thomas J, Henry, Timothy D, Metra, Marco, Hajjar, Roger J, Tendera, Michal, Behfar, Atta, Alexandre, Bertrand, Seron, Aymeric, Stough, Wendy Gattis, Sherman, Warren, Cotter, Gad, Wijns, W. i. l. l. i. a. m. Collaborators Clinical investigators, Dens, sites Belgium: Ziekenhuis Oost Limburg: J., Dupont, M., Mullens, W., Janssens, M., Dolatabadi, Hoˆpital Civil de Charleroi: D., De Bruyne, Y., Lalmand, J., Dubois, P., El Nakadi, B., Aminian, A., De Vuyst, E., Gurnet, P., Gujic, M., Blankoff, I., Guedes, CHU Mont Godinne UCL: A., Gabriel, L., Seldrum, S., Doyen, C., Andre´, M., Heyse, AZ Glorieux: A., Van Durme, F., Verschuere, J., Legrand, Domaine Universitaire du Sart Tilman: V., Gach, O., D’Orio, V., Davin, L., Lancellotti, P., Baudoux, E., Ancion, A., Dulgheru, R., Vanderheyden, OLV Ziekenhuis Aalst – Cardiologie: M., Bartunek, J., Wijns, W., Verstreken, S., Penicka, . M., Gelev, P. Meeus Bulgaria: Tokuda Hospital Sofia: V., Zheleva Kichukova, I., Parapunova, R., Melamed, R., Sardovski, S., Radev, O., Yordanov, A., Radinov, A., Nenov, D., Amine, I., Petrov, City Hospital Clinic Cardiology Center: I., Kichukov, K., Nikitasov, L., Stankov, Z., Stoyanov, H., Tasheva Dimitrova, I., Angelova, M., Dimitrov, E., Minchev, M., Garvanski, I., Botev, C., Polomski, P., Alexandrovska University Hospital, Vassilev, Sofia: D., Karamfiloff, K., Tarnovska Kadreva, R., Vladimirova, L., Dimitrov, G., Hadzhiev, E., Tzvetkova, G., Andreka, . M. Atanasova Hungary: Gottsegen Gyo¨ rgy Orszagos Kardiologiai Inte´zet: P., Fontos, G., Fabian, J., Csepregi, A., Uzonyi, G., Gelei, A., Edes, Debreceni Egyetem Orvos e´s Ege´szse´gtudomanyi Centrum Altalanos Orvostudomanyi Kar Kardiologia Inte´zet: I., Balogh, L., Vajda, G., Darago, A., Gergely, S., Fulop, T., Jenei, C., Horvath, Pe´csi Tudomanyegyetem Klinikai Ko¨zpont Szıvgyogyaszati Klinika: I., Magyari, B., Nagy, A., Cziraki, A., Faludi, R., Kittka, B., Alizadeh, H., Merkely, Semmelweis Egyetem Varosmajori Szıv e´s Ergyogyaszati Klinika: B., Geller, L., Farkas, P., Szombath, G., Foldes, G., Skopal, J., Kovacs, A., Kosztin, A., Gara, E., Sydo, N., Nyolczas, MH Ege´szse´gu¨gyi Ko¨zpont Kardiologiai Osztaly: N., Kerecsen, G., Korda, A., Kiss, . M., Borsanyi, T., Polgar, B., Muk, B., Sharif, Z. Bari Ireland: HRB Clinical Research Facility: F., Atar, Y. M. Smyth Israel:Western Galilee Hospital: S., Shturman, A., Akria, L., Kilimnik, M., Brezins, M., Halabi, Ziv Medical Center: M., Dally, N., Goldberg, A., Aehab, K., Rosenfeld, I., Levinas, T., Saleem, D., Katz, Barzilai Medical Center: A., Plaev, T., Drogenikov, T., Nemetz, A., Barshay, Y., Jafari, J., Orlov, I., Nazareth Hospital EMMS: M. Omory, N. Kogan Nielsen, Shochat, Hillel Yaffe Medical Center: M., Shotan, A., Frimerman, A., Meisel, S., Asif, A., Sofer, O., Blondheim, D. S., Vazan, A., Metra, L. Arobov Italy: A. O. Spedali Civili di Brescia: M., Bonadei, I., Inama, L., Chiari, E., Lombardi, C., Magatelli, M., Russo, D., Lazzarini, V., Carubelli, V., Vassanelli, AOUI Verona – Borgo Trento Hospital: C., Ribichini, Flavio Luciano, Bergamini, C., Krampera, Mauro, Cicoria, M. A., Zanolla, L., Dalla Mura, D., Gambaro, A., Rossi, A., Pesarini Poland: Jagiellonian University Department of Cardiac, G., Musialek, Vascular Diseases at John Paul II Hospital in Krakow: P., Mazurek, A., Drabik, L., Ka˛dzielski, A., Walter, Z., Dzieciuch Rojek, M., Rubis, P., Plazak, . W., Tekieli, L., Podolec, J., Orczyk, W., Sutor, U., Zmudka, K., Olszowska, M., Podolec, P., Gruchala, Uniwersyteckie Centrum Kliniczne: M., Ciecwierz, D., Mielczarek, M., Burakowski, S., Chmielecki, M., Zielinska, M., Frankiewicz, A., Wdowczyk, J., Stopczynska, I., Bellwon, J., Mosakowska, K., Nadolna, R., Wroblewska, J., Rozmyslowska, M., Rynkiewicz, M., Marciniak, I., Raczak, G., Tarnawska, M., Taszner, M., Kasprzak, Bieganski Hospital: J., Plewka, M., Fiutowska, D., Rechcinski, T., Lipiec, P., Sobczak, M., Weijner Mik, P., Wraga, M., Krecki, R., Markiewicz, M., Haval Qawoq, D., Wojakowski, Gornosla˛skie Centrum Medyczne Sla˛skie j. Akademii Medycznej: W., Ciosek, J., Dworowy, S., Gaszewska Zurek, E., Ochala, A., Cybulski, W., Jadczyk, T., Wanha, W., Parma, Z., Kozlowski, M., Dzierzak, M., Markiewicz Serbia: Clinical Hospital Center Zvezdara, M., Arandjelovic, Cardiology Clinic: A., Sekularac, N., Boljevic, D., Bogdanovic, A., Zivkovic, S., Cvetinovic, N., Loncar, G., Clinical Centre of Serbia, Beleslin, Cardiology Clinic: B., Nedeljkovic, M., Trifunovic, D., Giga, V., Banovic, M., Nedeljkovic, I., Stepanovic, J., Vukcevic, V., Djordjevic Dikic, A., Dobric, M., Obrenovic Kircanski, B., Seferovic, Cardiology Clinic: P., Orlic, D., Tesic, M., Petrovic, O., Milinkovic, I., Simeunovic, D., Jagic, Clinical Center of Kragujevac: N., Tasic, M., Nikolic, D., Miloradovic, V., Djurdjevic, P., Sreckovic, M., Zornic, N., Clinical Hospital Center Bezanijska Kosa, Radovanovic, Cardiology Department: S., Saric, J., Hinic, S., Djokovic, A., Ðordevic, S., Bisenic, V., Markovic, O., Stamenkovic, S., Malenkovic, V., Tresnjak, J., Misic, G., Cotra, D., Tomovic, L., Vuckovic, V., Clinic of Emergency Internal Medicine, Obradovic, Military Medical Academy: S., Jovic, Z., Vukotic, S., Markovic, D., Djenic, N., Ristic Andjelkov, A., Bayes Genis, D. Ljubinka Spain: Hospital Universitario Germans Trias I. Pujol: A., Rodriguez Leor, O., Labata, C., Vallejo, N., Ferrer, E., Batlle, M., Fernandez Aviles, Hospital General Universitario Gregorio Mara~non: F., Sanz Ruiz, R., Casado, A., Loughlin, G., Zatarain, E., Anguita, J., Ferna ndez Santos, M. E., Pascual, C., Bermejo, J., Hernandez Garcia, Hospital Clinico Universitario Virgen de la Victoria: J. M., Jimenez Navarro, M., Dominguez, A., Carrasco, F., Mu~noz, A., Garcia Pinilla, J. M., Ruiz, J., Queipo de Llano, M. P., Hernandez, A., Fernandez, A., Jimenez Quevedo, Hospital Clinico San Carlos: P., Guerra, R., Biagioni, C., Gonzalez, R. A., Gomez deDiego, J. J., Mansson Broberg, L. Perez de Isla Sweden: Karolinska University Hospital: A., Sylve´n, C., Leblanc, K., Winter, R., Blomberg, P., Gunyeli, E., Ruck, A., Silva, C., Fo¨rstedt Switzerland: CardioCentro Ticino, J., Moccetti, Switzerland: T., Rossi, M., Pasotti, E., Petrova, I., Crljenica, C., Monti, C., Murzilli, R., Su¨rder, D., Moccetti, M., Turchetto, L., Locicero, V., Chiumiento, L., Maspoli, S., Mombelli, M., Anesini, A., Biggiogero, M., Ponti, G., Camporini, C., Polledri, S., Hill, G. Dolci United Kingdom: Kings College Hospital: J., Plymen, C., Amin Youssef, G., Mcdonagh, T., Drasar, E., Mijovic, A., Jouhra, F., Mcloman, D., Dworakowski, R., Webb, I., Byrne, J., and Potter, V.

Subjects
0301 basic medicine, Male, Cardiopoiesis, Cardiovascular disease, Disease severity, Marker, Precision medicine, Regenerative medicine, Stem cell, Target population, Adult, Aged, Double-Blind Method, Female, Heart Failure, Humans, Mesenchymal Stem Cell Transplantation, Middle Aged, Myocardial Ischemia, Prospective Studies, Treatment Outcome, Young Adult, Cardiology and Cardiovascular Medicine, Cell- and Tissue-Based Therapy, mesenchymal stem-cells, 030204 cardiovascular system & hematology, Cardiorespiratory Medicine and Haematology, outcomes, Fast-Track Clinical Research, Sudden cardiac death, 0302 clinical medicine, Ischemia, cardiovascular disease, Clinical endpoint, target population, CHART Program, Ejection fraction, bone-marrow, Heart Failure/Cardiomyopathy, 3. Good health, Cohort, Cardiology, Fast Track, disease severity, delivery, medicine.medical_specialty, precision medicine, Clinical Sciences, regenerative medicine, 03 medical and health sciences, cardiopoiesis, Internal medicine, medicine, Adverse effect, marker, disease, business.industry, medicine.disease, mortality, Confidence interval, Clinical trial, stem cell, Editor's Choice, 030104 developmental biology, predictors, Cardiovascular System & Hematology, Heart failure, business
Abstract

Altres ajuts: This work was supported by Celyad, SA (Mont-Saint-Guibert, Belgium). Celyad has received research grants from the Walloon Region (Belgium, DG06 funding). Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischaemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion. Those achieving > 24 million mesenchymal stem cells (n = 315) were randomized to cardiopoietic cells delivered endomyocardially with a retention-enhanced catheter (n = 157) or sham procedure (n = 158). Procedures were performed as randomized in 271 patients (n = 120 cardiopoietic cells, n = 151 sham). The primary efficacy endpoint was a Finkelstein–Schoenfeld hierarchical composite (all-cause mortality, worsening heart failure, Minnesota Living with Heart Failure Questionnaire score, 6-min walk distance, left ventricular end-systolic volume, and ejection fraction) at 39 weeks. The primary outcome was neutral (Mann–Whitney estimator 0.54, 95% confidence interval [CI] 0.47–0.61 [value > 0.5 favours cell treatment], P = 0.27). Exploratory analyses suggested a benefit of cell treatment on the primary composite in patients with baseline left ventricular end-diastolic volume 200–370 mL (60% of patients) (Mann–Whitney estimator 0.61, 95% CI 0.52–0.70, P = 0.015). No difference was observed in serious adverse events. One (0.9%) cardiopoietic cell patient and 9 (5.4%) sham patients experienced aborted or sudden cardiac death. The primary endpoint was neutral, with safety demonstrated across the cohort. Further evaluation of cardiopoietic cell therapy in patients with elevated end-diastolic volume is warranted.

Published
2017

19. Sicca-Syndrom: Anamnese und Grundlagen der Therapie

Author

Markovic O, Cernak M, Bilek J, and Nepp J

Subjects
Mineralstoffwechsel, lcsh:R, Sicca-Syndrom, lcsh:Medicine, Optometrie
Abstract

Das Trockene Auge ist eine der am häufigsten gestellten Diagnosen in der Augenheilkunde. Die multifaktorielle Genese und die Vielfalt der zusätzlichen belastenden Faktoren ergeben einen schwierigen therapeutischen Zugang. Als Antwort auf diese Komplexität ist die gezielte Anamnese des Trockenen Auges von höchster Bedeutung. Der gesunde Tränenfilm besteht aus drei Schichten: der innersten Mucin- oder Proteinphase, der mittleren wässrigen Phase und äußeren Lipidphase. Jede einzelne dieser Phasen kann spezifische pathologische Veränderungen aufweisen, häufig sind es aber gemischte Phasenstörungen, die zum Sicca-Syndrom führen. Die Einleitung der Therapie sollte als Produkt der Kenntnisse der Pathophysiologie des Tränenfilms und einer ausführlichen Anamnese erfolgen. Zum Unterschied zum Facharzt, welchem eine breite Palette an Untersuchungsmethoden zur Quantifizierung und Charakterisierung der Erkrankung zur Verfügung steht, hat der fachfremde Arzt vor allem die Beschwerdesymptomatik als Leitlinie zur Therapieeinleitung. Subjektive Beschwerdequalitäten des Patienten können pathologischen Veränderungen am Tränenfilm zugeordnet werden. Aus dieser Zuordnung kann eine zielführende, der Phasenstörung entsprechende Therapie hergeleitet werden.

Published
2009

21. EARLY ELECTROCARDIOGRAM CHANGES IN HIGHLY TRAINED PREADOLESCENT FOOTBALL PLAYERS

Author

Zdravkovic, M., primary, Milovanovic, B., additional, Nedeljkovic, I., additional, Krotin, M., additional, Soldatovic, I., additional, Acimovic, T., additional, Koracevic, G., additional, Zdravkovic, D., additional, Prijic, S., additional, Vukomanovic, V., additional, Dimkovic, S., additional, Markovic, O., additional, Filipovic, B., additional, Stevanovic, P., additional, and Mazic, S., additional

Published
2015
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22. Correlation between ECG changes and early left ventricular remodeling in preadolescent footballers.

Author

Zdravkovic, M, Milovanovic, B, Hinic, S, Soldatovic, I, Durmic, T, Koracevic, G, Prijic, S, Markovic, O, Filipovic, B, and Lovic, D

Subjects
VENTRICULAR remodeling, LEFT ventricular hypertrophy, ELECTROCARDIOGRAPHY, PRETEENS
Abstract

The aim of this study was to assess the early electrocardiogram (ECG) changes induced by physical training in preadolescent elite footballers. This study included 94 preadolescent highly trained male footballers (FG) competing in Serbian Football League (minimum of 7 training hours/week) and 47 age-matched healthy male controls (less than 2 training hours/week) (CG). They were screened by ECG and echocardiography at a tertiary referral cardio center. Sokolow–Lyon index was used as a voltage electrocardiographic criterion for left ventricular hypertrophy diagnosis. Characteristic ECG intervals and voltage were compared and reference range was given for preadolescent footballers. Highly significant differences between FG and CG were registered in all ECG parameters: P-wave voltage (p < 0.001), S-wave (V1 or V2 lead) voltage (p < 0.001), R-wave (V5 and V6 lead) voltage (p < 0.001), ECG sum of S V1–2 + R V5–6 (p < 0.001), T-wave voltage (p < 0.001), QRS complex duration (p < 0.001), T-wave duration (p < 0.001), QTc interval duration (p < 0.001), and R/T ratio (p < 0.001). No differences were found in PQ interval duration between these two groups (p > 0.05). During 6-year follow-up period, there was no adverse cardiac event in these footballers. None of them expressed pathological ECG changes. Benign ECG changes are presented in the early stage of athlete's heart remodeling, but they are not related to pathological ECG changes and they should be regarded as ECG pattern of LV remodeling. [ABSTRACT FROM AUTHOR]

Published
2017
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24. A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1)

Author

Todoric-Živanović, B, Marisavljevic, D, Surace, C, Cemerikic, V, Markovic, O, Krtolica-Žikić, Koviljka, Tatomirovic, Z, Cikota, B, Magic, Z, Rocchi, M, Todoric-Živanović, B, Marisavljevic, D, Surace, C, Cemerikic, V, Markovic, O, Krtolica-Žikić, Koviljka, Tatomirovic, Z, Cikota, B, Magic, Z, and Rocchi, M

Abstract

Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or masked BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9) (p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21. (c) 2006 Elsevier Inc. All rights reserved.

Published
2006

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