1. Height deficit and impairment of the GH/IGF-1 axis in patients treated for acute lymphoblastic leukemia during childhood
- Author
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Marcos Borato Viana, Marina de Oliveira Serravite, Patrícia Carneiro de Brito, Natália Bragança Oliveira, Maria Ivone Oliveira Pinto Vilela, and Antônio Ribeiro-Oliveira
- Subjects
Male ,medicine.medical_specialty ,Drug-Related Side Effects and Adverse Reactions ,Endocrinology, Diabetes and Metabolism ,Lymphoblastic Leukemia ,medicine.medical_treatment ,Overweight ,Body Mass Index ,Young Adult ,Endocrinology ,Risk Factors ,Internal medicine ,medicine ,Endocrine system ,Humans ,In patient ,Insulin-Like Growth Factor I ,Testosterone ,Growth Disorders ,Retrospective Studies ,Chemotherapy ,Radiotherapy ,business.industry ,Age Factors ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Combined Modality Therapy ,Body Height ,Radiation therapy ,Child, Preschool ,Growth Hormone ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,Cranial Irradiation ,business ,Body mass index ,Follow-Up Studies ,Signal Transduction - Abstract
Background: Endocrine complications after acute lymphoblastic leukemia (ALL) are common. Methods: Final height, GH/IGF-1 axis, and body mass index were analyzed after 13.7 (7.0–20.7) years from diagnosis in 34 boys aged 4 and estradiol/testosterone were determined. Results: Final height was significantly reduced (mean Z-score for height between final height and diagnosis, ΔHAZ = –0.61, p = 0.0001). At that point, 3 patients were obese (4%) and 17 were overweight (22.7%). Patients aged ≤4 years at diagnosis and those irradiated had a greater loss in final height (p = 0.001 and p = 0.008, respectively). Abnormalities in GH/IGF-1 axis were observed in 4 patients: 3 had a GH peak Conclusions: Treatment of ALL during childhood is associated with final height deficit. Young age at diagnosis and radiotherapy were the major risk factors. GH/IGF-1 deficiency was found particularly in irradiated patients, even though it was detected in 1 non-irradiated patient.
- Published
- 2012