1. Exploring botulinum toxin’s impact on masseter hypertrophy: a randomized, triple-blinded clinical trial
- Author
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Bryanne Brissian de Souza Nobre, Luciana Rezende, Mariana Barbosa Câmara-Souza, Alfonso Sanchez-Ayala, Rodrigo Blass, Ana Claudia Carbone, Ana Cristina Manso, Malin Ernberg, Nikolaos Christidis, and Giancarlo De la Torre Canales
- Subjects
Botulinum toxin type A ,Masseter hypertrophy ,Muscle thickness ,Masticatory performance ,Medicine ,Science - Abstract
Abstract The present study aimed to assess the effectiveness and functional adverse effects of a single and multiple injections of botulinum toxin A (BoNT-A) for masseter hypertrophy (MH). Twenty-six women complaining about lower third facial enlargement due to MH, received 75 U of BoNT-A (abobotulinum toxin) in each masseter muscles. After 3 months, patients were randomly assigned to receive a second treatment session of Saline Solution: (G1; n = 11) or BoNT-A: (G2; n = 12). Muscle thickness (ultrasound), electrical activity (electromyography; EMG), masticatory performance, and subjective perception of MH were evaluated. Follow-up was performed at 1, 3 and 6 months. Muscle thickness, EMG activity, and masticatory performance were analyzed using ANOVA two-way and Sidak test as post-hoc. Masticatory performance was analyzed by the Friedman’s test and Mann–Whitney test. Regarding inter-groups comparisons, there was a significant decrease in the left masseter muscle thickness in the G2 group at the 6 month follow-up (p 0.05) and a higher improvement in subjective perception of MH was observed in the 1 month follow-up for G2 (p
- Published
- 2024
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