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28 results on '"Mangoni, G."'

13. Effect of hyperbaric oxygen therapy in experimental subcutaneous and pulmonary infections due to Pseudomonas aeruginosa

Author

Carlo Luongo, Imperatore, F., Matera, M. G., Mangoni, G., Marmo, M., Baroni, A., Catalanotti, P., Rossi, F., Filippelli, A., Luongo, Carlo, Imperatore, F, Matera, Maria Gabriella, Mangoni, G, Marmo, M, Baroni, Adone, Catalanotti, Piergiorgio, Rossi, Francesco, and Filippelli, A.

Subjects
Lung Diseases, Male, Hyperbaric Oxygenation, Amikacin, therapeutic use, Animals, Anti-Bacterial Agents, therapeutic use, Combined Modality Therapy, Hyperbaric Oxygenation, Lung Diseases, drug therapy/microbiology/therapy, Male, Pseudomonas Infections, drug therapy/microbiology/therapy, Pseudomonas aeruginosa, Rats, Rats, Wistar, Skin Diseases, Bacterial, drug therapy/microbiology/therapy, Wistar, Skin Diseases, Bacterial, Combined Modality Therapy, Skin Diseases, Anti-Bacterial Agents, Rats, therapeutic use, Pseudomonas aeruginosa, Animals, Pseudomonas Infections, Rats, Wistar
Abstract

About 80% of nosocomial infections are caused by aerobic bacteria. Pseudomonas aeruginosa is a Gram-negative bacterium belonging to the Pseudomonadaceae family; P. aeruginosa is responsible for 6-22% of all hospital infections. The aim of this study was to evaluate the efficacy of hyperbaric oxygen (HBO2) therapy (2 atm abs x 55 min.day-1) alone for 8 days and combined with antibiotic chemotherapy (amikacin 15 mg.kg-1.day-1 for 8 days by intraperitoneal route) in rats infected subcutaneously and via the pulmonary route. In the rats infected by P. aeruginosa, HBO2 induced a reduction in mortality and morbidity with bacteria eradication in blood culture, bronchial aspirate, and skin biopsies when compared to control. These effects were increased by the use of amikacin, an antibiotic used for the treatment of sensitive Gram-negative bacteria.

Published
1999

17. 'Treatment of acute non lymphocytic leukemia. Results of a perspective trial of Daunorubicin, Arabinosyl-Cytosine and 6-Thioguanine (DAT) versus DAT plus Vindesine and Etoposide'

Author

5. Bandini G., Baccarani, M., Cavazzini, G., Battista, R., Leoni, F., Morra, E., Comotti, B., Scapoli, G., Todeschini, G., Mangoni, G., Zuffa, E., Giudice, V., Zaccaria, A., Fanin, Renato, Fasola, G., Damiani, Daniela, Gallizia, C., Michieli, M., Dini, E., Rossi Ferrini, P., Bernasconi, C., Barbui, T., Castoldi, G. L., Perona, G., Rizzoli, V., Di Prisco, U., and Tura, S.

Published
1987

18. Local infiltration of tramadol as an effective strategy to reduce post-operative pain: a systematic review protocol and meta-analysis

Author

Maria Caterina Pace, Vincenzo Pota, Giuseppe Mangoni, Aniello Alfieri, Maria Beatrice Passavanti, Sveva Di Franco, Giacomo Piccinno, Pasquale Sansone, Marco Fiore, Caterina Aurilio, Passavanti, M. B., Piccinno, G., Alfieri, A., Di Franco, S., Sansone, P., Mangoni, G., Pota, V., Aurilio, C., Pace, M. C., and Fiore, M.

Subjects
medicine.medical_specialty, Visual analogue scale, Analgesic, MEDLINE, lcsh:Medicine, Medicine (miscellaneous), 03 medical and health sciences, 0302 clinical medicine, Meta-Analysis as Topic, Rating scale, Protocol, Humans, Medicine, Tramadol, Analgesics, Pain, Postoperative, business.industry, lcsh:R, 030206 dentistry, 030220 oncology & carcinogenesis, Meta-analysis, Local infiltration, Physical therapy, business, Post operative pain, Systematic Reviews as Topic, medicine.drug
Abstract

Objective The purpose of this review is to evaluate the use and effectiveness of the local administration of tramadol in reducing post-operative pain during surgical interventions. Methods The PubMed, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases will be searched for this review. This systematic review will include studies evaluating the clinical efficacy of the local infiltration of tramadol, with no study design restrictions. Only studies that present clear descriptions of local tramadol administration are published in peer-reviewed journals in the English, Italian, Spanish, French, Portuguese or German language and are published in full will be taken into consideration. A meta-analysis will be performed when there is sufficient clinical homogeneity among the retrieved studies, and only randomized controlled studies and quasi-randomized controlled studies will be included. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used to assess the certainty in the evidence. If a quantitative analysis cannot be conducted, a qualitative description of the results of the retrieved studies will be provided. Results A high-quality synthesis of the current evidence on the local administration of tramadol for managing post-surgical pain will be illustrated using subjective reports and objective measures of performance. The primary outcomes will include the magnitude of post-operative pain intensity improvement, with improvement being as defined by a reduction by at least 2 points in the visual analogue scale (VAS) score or numerical rating scale (NRS) score. The secondary outcomes will be the magnitude of reduction in tramadol rescue doses and in other analgesic drug doses. Conclusion This protocol will present evidence on the efficacy of tramadol in relieving post-surgical pain. Systemic review registration PROSPERO CRD42018087381

Published
2020
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19. Noterelle di conferma sull'interesse legittimo

Author

GUIDO CLEMENTE DI SAN LUCA, C. Acocella, G. Acocella, S. Amorosino, F.G. Angelini, S. Antoniazzi, M. Antonioli, A. Areddu, G. Armao, F. Armenante, F. Astone, A. Barone, A. Bartolini, A. Benedetti, C. Benetazzo, V. Berlingò, E. Boscolo, C. Bottari, F. Laus, C. Cacciavillani, M. Cafagno, M. Calabrò, V. Caputi Jambrenghi, A. Angiuli, A. Caracciolo La Grotteria, E. Caracciolo La Grotteria, E. Cardi, E. Carloni, G.F. Cartei, G. Carullo, A. Cassatella, A. Catelani, M.C. Cavallaro, C. Celone, G. Chiara, P. Chirulli, M.P. Chiti, F. Cimbali, S. Cimini, F. Cintioli, A. Cioffi, M. Clarich, G. Clemente di San Luca, M. Cocconi, G. Cocozza, S. Cognetti, A. Colavecchio, G. Colombini, G.D. Comporti, A. Contieri, G. Corso, F. Costantino, G. Crepaldi, A. Crismani, A. Crosetti, C. Cudia, C. Cupelli, F. D'Angelo, M. D'Angelosante, S. D'Antonio, M. D'Arienzo, G. D'Emma, D. D'Orsogna, M. D'Orsogna, D. De Carolis, M. De Cristofaro, M. De Donno, G. De Giorgi Cezzi, F. de Leonardis, G. De Maio, E. De Marco, G.C. De Martin, R. De Nictolis, A. De Siano, G. della Cananea, M.G. Della Scala, M. Delsignore, S. Dettori, A. Di Giovanni, M. Dipace, R. Dipace, V. Domenichelli, M. Dugato, V. Fanti, C. Feliziani, L. Ferrara, M.V. Ferroni, F. Figorilli, W. Giulietti, O. Fiumara, E. Follieri, P. Forte, M. Fracanzani, F. Fracchia, F. Francario, F. Gaffuri, D.U. Galetta, C.E. Gallo, F. Gallo, F. Gambardella, G. Gargano, F. Gaspari, V. Gasparini Cesari, W. Gasparri, M.P. Genesin, L. Giani, E. Giardino, F. Giglioni, V. Giomi, A. Giusti, M. Gola, G. Greco, P. Grossi, C. Guacci, N. Gullo, G. Guzzardo, A. Iacopino, G. Iacovone, M. Immordino, I. Impastato, M. Interlandi, M. Ippolito, L. Lamberti, S. Lariccia, A. Lazzaro, G. Leone, G.F. Licata, S. Licciardello, F. Liguori, P. Lombardi, R. Lombardi, N. Longobardi, F. Lubrano, S. Lucattini, M. Luciani, A. Lupo, L. Maccarrone, M. Macchia, A. Maltoni, B. Mameli, F. Manganaro, V. Manzetti, F. Marinelli, D. Marongiu, D. Marrama, G. Martini, A. Massera, A. Masucci, M. Mazzamuto, F. Merusi, S. Mirate, V. Molaschi, G. Morbidelli, L. Murgolo, C.M.A. Orrei, G. Pagliari, C. Pagliarin, G. Palma, M. Palma, G. Palmieri, N. Paolantonio, P. Patrito, S. Pellizzari, L.R. Perfetti, S. Perongini, E. Picozza, G. Piperata, A. Police, P.L. Portaluri, G.A. Primerano, A. Proto Pisani, M. Protto, P. Provenzano, A. Pubusa, F. Pubusa, S. Puddu, M. Ragusa, M. Ramajoli, M. Renna, R. Rolli, E. Romano, M.C. Romano, A. Romeo, G. Rossi, F. Saitta, N. Saitta, F. Salvia, L. Sambucci, A. Sandulli, M.A. Sandulli, F. Satta, E.F. Schlitzer, D. Siclari, A. Simonati, H. Simonetti, B. Sordi, G. Sorrentino, R. Spagnuolo Vigorita, B. Spampinato, M.R. Spasiano, P. Stella Richter, P. Tanda, S. Tarullo, A. Tigano, F. Tigano, M. Timo, R. Titomanlio, M. Trimarchi, W. Troise Mangoni, G. Tropea, A. Giannelli, F.F. Tuccari, S. Tuccillo, G. Urbano, R. Ursi, S. Vasta, G. Vercillo, G. Vesperini, F. Vetrò, N. Vettori, C. Videtta, S. Villamena, R. Villata, P.M. Vipiana, F. Zammartino, A. Zito, and CLEMENTE DI SAN LUCA, Guido

Published
2020

20. Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system

Author

Vito de Novellis, Sabatino Maione, Catia Giordano, Enza Palazzo, Daniela Vita, Giuseppe Mangoni, Ida Marabese, Stefania Petrosino, Francesco Rossi, Vincenzo Di Marzo, Palazzo, Enza, DE NOVELLIS, Vito, Petrosino, S., Marabese, Ida, Vita, D., Giordano, C., DI MARZO, V., Mangoni, G. S., Rossi, Francesco, and Maione, Sabatino

Subjects
Male, Serotonin, Cannabinoid receptor, Hot Temperature, medicine.medical_treatment, Microdialysis, Morpholines, Action Potentials, Arachidonic Acids, Pharmacology, Naphthalenes, Neuropathic pain, Serotonergic, chemistry.chemical_compound, Dorsal raphe nucleus, Piperidines, chronic constriction injury of the sciatic nerve, serotonergic system, Cannabinoid Receptor Modulators, medicine, Reaction Time, Animals, Drug Interactions, endocannabinoid system, Rats, Wistar, Pain Measurement, Neurons, Analysis of Variance, Behavior, Animal, business.industry, General Neuroscience, Anandamide, Endocannabinoid system, Benzoxazines, Rats, Disease Models, Animal, chemistry, Hyperalgesia, Touch, AM404, Pyrazoles, Raphe Nuclei, Cannabinoid, medicine.symptom, Rimonabant, Sciatic Neuropathy, business, Endocannabinoids
Abstract

We used a model of neuropathic pain consisting of rats with chronic constriction injury (CCI) of the sciatic nerve, in order to investigate whether endocannabinoid levels are altered in the dorsal raphe (DR) and to assess the effect of repeated treatment with (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate, a synthetic cannabinoid agonist, or N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404), an inhibitor of endocannabinoid reuptake, on DR serotonergic neuronal activity and on behavioural hyperalgesia. CCI resulted in significantly elevated anandamide but not 2-arachidonoylglycerol levels in the DR. Furthermore, as well as thermal and mechanical hyperalgesia, CCI caused serotonergic hyperactivity (as shown by the increase of basal activity of serotonergic neurones, extracellular serotonin levels and expression of 5-HT1A receptor gene). Repeated treatment with either (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[ 1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate or AM404 reverted the hyperalgesia and enhanced serotonergic activity induced by CCI in a way attenuated by N-piperidino-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4-methyl-3- pyrazolecarboxamide, a selective cannabinoid subtype 1 (CB1) receptor antagonist. Despite the elevated levels of anandamide following CCI, N-piperidino-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4-methyl-3-pyrazolecarboxamide did not produce hyperalgesia or any other effect on serotonergic neuronal activity when administered alone. Furthermore, the effects of AM404 were not accompanied by an increase in endocannabinoid levels in the DR. In conclusion, following CCI of the sciatic nerve, the endocannabinoid and serotonergic systems are activated in the DR, where repeated stimulation of CB1 receptors with exogenous compounds restores DR serotonergic activity, as well as thermal and mechanical nociceptive thresholds, to pre-surgery levels. However, an elevated level of endogenous anandamide in the DR does not necessarily contribute to the CB1-mediated tonic control of analgesia and serotonergic neuronal activity.

Published
2006

21. Effects of hyperbaric oxygen exposure on a zymosan-induced shock model

Author

Franco Portolano, Giuseppe Mangoni, Francesco Imperatore, Amelia Filippelli, Francesco Rossi, Maria Antonietta Scafuro, Salvatore Cuzzocrea, Carlo Luongo, Luongo, Carlo, Imperatore, F, Cuzzocrea, S, Filippelli, A, Scafuro, Mariantonietta, Mangoni, G, Portolano, F, and Rossi, Francesco

Subjects
Male, Time Factors, Saccharomyces cerevisiae, chemistry.chemical_element, Inflammation, Peritonitis, Pharmacology, Critical Care and Intensive Care Medicine, Nitric Oxide, Oxygen, Nitric oxide, Rats, Sprague-Dawley, chemistry.chemical_compound, Random Allocation, Hyperbaric oxygen therapy, Intensive care, Medicine, Animals, Hyperbaric oxygen therapy, Nitric oxide, Peritonitis, Shock, Tumor necrosis factor-α, Zymosan, Hyperbaric Oxygenation, biology, business.industry, Tumor Necrosis Factor-alpha, Zymosan, Shock, biology.organism_classification, Survival Analysis, Tumor necrosis factor-α, Rats, Disease Models, Animal, chemistry, Shock (circulatory), Immunology, Tumor necrosis factor alpha, medicine.symptom, business
Abstract

To evaluate the effects of hyperbaric oxygen (HBO) therapy on zymosan-induced shock in rats. Zymosan, a cell wall component of the yeast Saccharomyces cerevisiae, induces inflammation by causing the production of various cytokines and pro-inflammatory mediators. The administration of zymosan to rats represents a new experimental shock model by inducing acute peritonitis, severe hypotension, and signs of systemic illness. However, it has been recently proposed that the zymosan-induced shock, like septic shock, may be mediated by overproduction of nitric oxide.Experimental study.Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy.Male rats were treated with zymosan (500 mg/kg) by intraperitoneal route, with HBO (2 Absolute Atmosphere) or with zymosan and HBO (2 Absolute Atmosphere).Peritoneal exudate, plasma, and peritoneal nitric oxide metabolites (NOx) and zymosan determined a time-dependent increase in peritoneal and plasma NOx concentrations, and peritoneal leukocytes were determined. Moreover, symptomatology was observed. The administration of zymosan caused the appearance of a severe illness in the rats characterized by ruffled fur, lethargy, conjunctivitis, diarrhea, and a significant loss of body weight. All zymosan-treated rats developed an acute peritonitis, producing turbid exudate. Zymosan determined a time-dependent increase in peritoneal, plasma NOx, and tumor necrosis factor (TNF)-alpha concentrations. Morbidity of zymosan shocked rats has been attenuated and no mortality was observed by treatment with HBO. These findings were associated with a significant reduction either of peritoneal leukocytes and exudate, or plasma and peritoneal NOx concentrations. Moreover, TNF-alpha levels were significantly reduced in animals shocked by zymosan and treated with HBO.

Published
1999

22. Formazione ed espansione dei partiti

Author

MUSELLA, LUIGI, F. BARBAGALLO, F. DE FELICE, M. G. ROSSI, N. TRANFAGLIA, G. MORI, L. MANGONI, G. BARONE., and Musella, Luigi

Subjects
Partiti, Repubblica, Italia
Abstract

La storia dei partiti politici in Italia dal dopoguerra alla metà degli anni Settanta. La nascita e la formazione dei partiti organizzati. Gli aspetti strutturali del sistema. Gli anni Cinquanta. Da De Gasperi a Fanfani. La vecchia e la nuova classe politica. La Dc di Moro. La crisi del Pci e il nuovo ruolo del Psi. La formazione di nuove reti politiche. Gli anni Settanta. L'individualizzarsi del voto. Clientelismo e corruzione.

Published
1995

23. I sindacati nel sistema politico

Author

MUSELLA, LUIGI, F. BARBAGALLO, F. DE FELICE, M. G. ROSSI, N. TRANFAGLIA, G. MORI, L. MANGONI, G. BARONE., and Musella, Luigi

Subjects
sistema politico, sindacato, italia repubblicana
Published
1994

24. Role of hyperbaric oxygen exposure in reduction of lipid peroxidation and in multiple organ failure induced by zymosan administration in the rat.

Author

Cuzzocrea S, Imperatore F, Costantino G, Luongo C, Mazzon E, Scafuro MA, Mangoni G, Caputi AP, Rossi F, and Filippelli A

Subjects
Animals, Male, Malondialdehyde metabolism, Multiple Organ Failure chemically induced, Multiple Organ Failure pathology, Peritonitis chemically induced, Peritonitis complications, Peroxidase metabolism, Rats, Rats, Sprague-Dawley, Tyrosine analogs & derivatives, Tyrosine metabolism, Zymosan toxicity, Hyperbaric Oxygenation adverse effects, Lipid Peroxidation drug effects, Multiple Organ Failure metabolism
Abstract

The aim of the present study was to evaluate the effects of hyperbaric oxygen (HBO) therapy on multiple organ failure induced by zymosan. Administration of zymosan (500 mg/kg) in the rat induced neutrophil infiltration in the lung, liver, and intestine as evaluated by increase in myeloperoxidase (MPO) activity. Therefore, lipid peroxidation was significantly increased in zymosan-treated rats. This inflammatory process coincided with the damage of lung, liver, and small intestine. Immunohistochemical examination demonstrated a marked increase in the immunoreactivity to nitrotyrosine in the lung, liver, and small intestine of zymosan-shocked rats. HBO (2 absolute Atmosphere) exposure attenuates the increase in the tissue levels of MPO and malondialdehyde (MDA) caused by zymosan in the lung, liver, and intestine. In addition, HBO (2 absolute Atmosphere) was effective in preventing the development of lung, liver, and intestine injury. Taken together, the present results demonstrate that HBO may also be an efficacious treatment in multiple organ failure induced by zymosan.

Published
2000
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25. Effect of hyperbaric oxygen therapy in experimental subcutaneous and pulmonary infections due to Pseudomonas aeruginosa.

Author

Luongo C, Imperatore F, Matera MG, Mangoni G, Marmo M, Baroni A, Catalanotti P, Rossi F, and Filippelli A

Subjects
Amikacin therapeutic use, Animals, Anti-Bacterial Agents therapeutic use, Combined Modality Therapy, Lung Diseases drug therapy, Lung Diseases microbiology, Male, Pseudomonas Infections drug therapy, Pseudomonas Infections microbiology, Pseudomonas aeruginosa, Rats, Rats, Wistar, Skin Diseases, Bacterial drug therapy, Skin Diseases, Bacterial microbiology, Hyperbaric Oxygenation, Lung Diseases therapy, Pseudomonas Infections therapy, Skin Diseases, Bacterial therapy
Abstract

About 80% of nosocomial infections are caused by aerobic bacteria. Pseudomonas aeruginosa is a Gram-negative bacterium belonging to the Pseudomonadaceae family; P. aeruginosa is responsible for 6-22% of all hospital infections. The aim of this study was to evaluate the efficacy of hyperbaric oxygen (HBO2) therapy (2 atm abs x 55 min.day-1) alone for 8 days and combined with antibiotic chemotherapy (amikacin 15 mg.kg-1.day-1 for 8 days by intraperitoneal route) in rats infected subcutaneously and via the pulmonary route. In the rats infected by P. aeruginosa, HBO2 induced a reduction in mortality and morbidity with bacteria eradication in blood culture, bronchial aspirate, and skin biopsies when compared to control. These effects were increased by the use of amikacin, an antibiotic used for the treatment of sensitive Gram-negative bacteria.

Published
1999

26. Effects of hyperbaric oxygen exposure on a zymosan-induced shock model.

Author

Luongo C, Imperatore F, Cuzzocrea S, Filippelli A, Scafuro MA, Mangoni G, Portolano F, and Rossi F

Subjects
Animals, Male, Nitric Oxide blood, Nitric Oxide physiology, Random Allocation, Rats, Rats, Sprague-Dawley, Shock chemically induced, Shock immunology, Shock metabolism, Survival Analysis, Time Factors, Tumor Necrosis Factor-alpha metabolism, Zymosan, Disease Models, Animal, Hyperbaric Oxygenation methods, Shock therapy
Abstract

Objective: To evaluate the effects of hyperbaric oxygen (HBO) therapy on zymosan-induced shock in rats. Zymosan, a cell wall component of the yeast Saccharomyces cerevisiae, induces inflammation by causing the production of various cytokines and pro-inflammatory mediators. The administration of zymosan to rats represents a new experimental shock model by inducing acute peritonitis, severe hypotension, and signs of systemic illness. However, it has been recently proposed that the zymosan-induced shock, like septic shock, may be mediated by overproduction of nitric oxide., Design: Experimental study., Setting: Institute of Pharmacology and Toxicology, 2nd University of Naples, Naples, Italy., Subjects: Male rats were treated with zymosan (500 mg/kg) by intraperitoneal route, with HBO (2 Absolute Atmosphere) or with zymosan and HBO (2 Absolute Atmosphere)., Measurements and Main Results: Peritoneal exudate, plasma, and peritoneal nitric oxide metabolites (NOx) and zymosan determined a time-dependent increase in peritoneal and plasma NOx concentrations, and peritoneal leukocytes were determined. Moreover, symptomatology was observed. The administration of zymosan caused the appearance of a severe illness in the rats characterized by ruffled fur, lethargy, conjunctivitis, diarrhea, and a significant loss of body weight. All zymosan-treated rats developed an acute peritonitis, producing turbid exudate. Zymosan determined a time-dependent increase in peritoneal, plasma NOx, and tumor necrosis factor (TNF)-alpha concentrations. Morbidity of zymosan shocked rats has been attenuated and no mortality was observed by treatment with HBO. These findings were associated with a significant reduction either of peritoneal leukocytes and exudate, or plasma and peritoneal NOx concentrations. Moreover, TNF-alpha levels were significantly reduced in animals shocked by zymosan and treated with HBO.

Published
1998
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27. Effects of hyperbaric oxygen exposure on non-adrenergic non-cholinergic responses of rat trachea.

Author

Matera MG, Imperatore F, D'Agostino B, Amorena M, Luongo C, Mangoni G, Scafuro MA, Portolano F, and Rossi F

Subjects
Animals, Arginine pharmacology, Electric Stimulation, In Vitro Techniques, Male, Muscle Contraction drug effects, Muscle Contraction physiology, Muscle Relaxation drug effects, Muscle Relaxation physiology, NG-Nitroarginine Methyl Ester pharmacology, Nitric Oxide physiology, Nitric Oxide Synthase antagonists & inhibitors, Rats, Rats, Wistar, Trachea drug effects, Trachea enzymology, Trachea metabolism, Hyperbaric Oxygenation, Receptors, Adrenergic physiology, Receptors, Cholinergic physiology, Trachea physiology
Abstract

The effects of prolonged (20 day) hyperbaric exposure (HBO) to oxygen on non adrenergic non cholinergic (NANC) contractile and relaxant responses of rat trachea were examined. The electrical field stimulation (EFS) of rat tracheal rings was performed at 30 Hz and contractile and relaxant responses were assessed in the absence or in the presence of pretreatment with L-nitro-arginine-methyl-ester (L-NAME), an inhibitor of NO synthase, and L-Arginine (L-ARG), a precursor of NO synthesis, plus L-NAME. Our data demonstrated that L-NAME significantly (p < 0.05) enhanced the contractile responses induced by EFS (controls 30.6 +/- 0.99%; L-NAME 76.07 +/- 2.00%) and statistically (p < 0.05) reduced the relaxant component of EFS (controls 31.10 +/- 0.46; L-NAME 15.00 +/- 0.12); these effects were reversed when tissues were pretreated with L-ARG plus L-NAME, suggesting that NO plays a modulatory role in cholinergic neurotransmission and participates in EFS relaxant responses. Moreover, prolonged HBO exposure (20 days) at 202.6 and 303.9 kPa did not modify the contractile or relaxant responses induced by EFS, nor modify the L-NAME or L-ARG effects on EFS responses.

Published
1997

28. [Effects of hyperbaric oxygenation in skin and pulmonary infections caused by Pseudomonas aeruginosa].

Author

Marmo M, Contaldi G, Luongo C, Imperatore F, Tufano MA, Catalanotti P, Baroni A, Mangoni G, Stefano S, and Rossi F

Subjects
Animals, Combined Modality Therapy, Lung Diseases drug therapy, Male, Pseudomonas Infections drug therapy, Rats, Rats, Sprague-Dawley, Skin Diseases, Bacterial drug therapy, Amikacin therapeutic use, Anti-Bacterial Agents therapeutic use, Hyperbaric Oxygenation, Lung Diseases therapy, Pseudomonas Infections therapy, Skin Diseases, Bacterial therapy
Abstract

About 80% of nosocomial infections are caused by aerobic bacteria. The Pseudomonas aeruginosa is a Gram-negative bacterium pertaining to the Pseudomonadaceae family. P. aeruginosa is responsible for 6-22% of all hospital infections. The aim of this paper is to evaluate the efficacy of both hyperbaric oxygen-therapy (HBO 2 Atm x 35 min/day) alone for 8 days and when associated to the chemoantibiotic therapy (amikacine 15 mg/kg/day for 8 days intraperitoneal), in rats infected through pulmonary and subcutaneous intake. In rats affected by P. aeruginosa, HBO induces a significant reduction in mortality and morbility with bacteria eradication in blood culture findings, bronchial aspirate and skin biopsies. These effects were increased by the use of amikacine which is an antibiotic used for the treatment of Gram-negative bacteria.

Published
1996

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