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Early-life experience influences subsequent maturation and function of the adult brain, sometimes even in a sex-specific manner, but underlying molecular mechanisms are poorly understood. We describe here how juvenile experience defines sexually dimorphic synaptic connectivity in the adult Caenorhabditis elegans nervous system. Starvation of juvenile males disrupts serotonin-dependent activation of the CREB transcription factor in a nociceptive sensory neuron, PHB. CREB acts through a cascade of transcription factors to control expression of an atypical cadherin protein, FMI-1/Flamingo/CELSR. During postembryonic development, FMI-1 promotes and maintains synaptic connectivity of PHB to a command interneuron, AVA, in both sexes, but a serotonin-dependent transcriptional regulatory cassette antagonizes FMI-1 expression in males, thereby establishing sexually dimorphic connectivity between PHB and AVA. A critical regulatory node is the CREB-target LIN-29, a Zn finger transcription factor that integrates four layers of information: sexual specificity, past experience, time and cell-type specificity. Our findings provide the mechanistic details of how an early juvenile experience defines sexually dimorphic synaptic connectivity. [ABSTRACT FROM AUTHOR]

Expanding the industrial component through investment in R&D is a crucial objective of the region's current industrial strategy. Significant research and investment opportunities must complement the effectiveness of the region's industrial policy. Few studies have attempted to understand the interactions between inter-organizational clusters and the capacity to sustain those clusters; most studies on innovation capacity focus on the business level. This article suggests using the One Belt All Road (OBAR) strategic framework to assess regional industry's cluster innovation capacity (CIC) and international trade and investment. The cluster innovation capability was developed using a theoretical framework through qualitative textual assessment. As a result, information management, diffusion, and acquisition capacity are the three primary abilities that make up the cluster innovation capacity. The degree of investment effort in the region's industrial sectors and the factors influencing corporate innovation have been found to be correlated. The research highlighted obstacles and potential remedies for encouraging creative thinking and financial backing among regional manufacturers. Compared to the current system, the suggested system (OBAR) achieves superior results in accuracy (87.6%), system dependability (94.8%), the F-1 measure (87.1%), and error rate (8.1%). [ABSTRACT FROM AUTHOR]

Resource Management in Physical Education (RMPE) is the term used to describe the management of the curriculum, materials, and human resources needed for Physical Education (PE). Due to increased sports and physical activity participation, student performance in PE classes across all schools and universities has decreased. According to the analysis, it is hard for the available PE educators and managers to establish a relationship between all the resources. This study uses a robotic system with 5G capability for RMPE. The Big Data Analytics-based Artificial Neural Network method (BDA-ANNA) handles all PE resources in this computerized system. The BDA-ANNA can efficiently increase RMPE work quality and efficiency, enabling managers to obtain and save appropriate information accurately and quickly. With assistance from the robotic system, the material stock may be maintained. With the aid of BDA-ANNA, the mechanical system can keep the material stored. Automated systems with 5G capabilities can provide PE instructors with complete remote-control access with a 2-millisecond latency. These two clauses mandate that the RMPE supervise athletic events and physical activity. The suggested 5 G-enabled robotic systems for RMPE can manage all the resources effectively and efficiently with a low error rate. The advanced system and BDA-ANNA were put through a simulation exercise, demonstrating their independence in classifying and managing resources while reducing processing time. The experimental result improves a prediction ratio of 95.5 %, a learning ratio of 90.5%, an error rate of 92.3%, an Efficiency ratio of 96.6%, an Accuracy ratio of 92.5%, and performance ratio of 96.7%, a Movement Detection ratio of 90.7% compared to other methods. [ABSTRACT FROM AUTHOR]

Athletes health monitoring plays a vital role because the changes in their heart rate reduce their physical activity and contribution. The changes in athlete activities cause developing risk that affects their outcome. Therefore, athletes' heart rates should be monitored frequently to minimize the risk factors and improve their health. This work uses wearable sensor devices to monitor their health condition continuously. The wearable devices on their health record their Electrocardiogram (ECG), which is transferred to the health care centre. With the help of the ECG, this work Sportsperson Heart Rate Monitoring (HRMS-SP) is created. The gathered ECG information is processed using the Fuzzy Clustering (FC) algorithm to predict the Heart Rate Variability (HRV). According to the HRV value, athlete's mental stress level and their sports contribution were also investigated to minimize the computation complexity. In addition, the wearable device-based collected information was investigated using the fuzzy and big data analytics used to monitor people frequently. The predicted information is used to monitor, treat, prevent, and predict the sports person's activities effectively. During the analysis, Hadoop, Visualization, and data mining processes are applied to extract the health information from large datasets that are used to improve the athlete health monitoring systems. [ABSTRACT FROM AUTHOR]

A smart city's smart economy thrives in various areas, including political strategy, operational efficiency, and innovation management. Business models in smart urban must be based on a new sustainable development strategy, one that conserves natural resources while safeguarding the environment. Therefore, this paper proposes Statistical Business Models (SBM) to enhance the business strategies for developing the economy in smart cities. Economic status in smart cities and changes in business models are part of SBM, a set of design concepts. Smart Business Models (SBM) are business strategies that take advantage of current economic situations by leveraging the power of influential smart communities. The implementation of data systems and business models is the foundation for a systematic study of managing the economy in a smart city. There are several connections between SDM's critical assessments of business models and the global economy and the business models. The experimental findings suggest that the proposed SBM achieves the highest statistical rate with sales revenue up to 95.23 %, gross margin ratio of 80.5%, consumer satisfaction ratio of 96.34%, efficiency ratio of 93.82%, and maintenance cost ratio of 15.08% compared to another existing method. [ABSTRACT FROM AUTHOR]

The science of achieving a healthy mind, body, and spirit through objectives and activities is known as personal health (PH). We must be aware of our mental, bodily, and social well-being. The term "hygiene" refers to a wide variety of healthy behaviours. Individuals' healthcare costs and quality of life increased by avoiding or reducing the long-term effects of the disease through knowledge and skills. Biomedical apparel includes sutures, vascular grafts, and biodegradable clothes (BC). Biomedical clothing is anything implanted or incorporated into the human body and used near tissue, blood, or cells. Quick, dependable, and energyefficient connectivity between wireless sensor networks is necessary (WSNs). Physical layers, media access control, networking layers, and control requirements must be co-designed. For those with lesser means, health insurance will increase in cost. There are difficulties with privacy and cyber security, a higher chance of malpractice claims, and increased time and financial expenditures for doctors and patients. In this study, wireless sensor networks-based personal health biomedical clothing (PH-BC-WSN) was utilized to increase access to high-quality healthcare, increase food production through precision agriculture, and raise the standard of human resources. More effective healthcare and medical asset monitoring systems can be developed thanks to the Internet of Things. Eavesdropping on medical data, modification, fabrication of warnings, denial of service, user tracking and location, physical interference with equipment, and electromagnetic threats were extensively discussed. The article gives several instances of current technology, discusses design challenges including energy efficiency, security, and scalability, provides various demonstrations of current technology, and provides a complete analysis of all the advantages and disadvantages. Despite their many benefits, body sensor networks have several significant obstacles and unresolved research problems, which are described along with some potential answers. As a result, the experimental findings demonstrate that PH-BC-WSN enhances accuracy and reduces response time in inpatient health monitoring. [ABSTRACT FROM AUTHOR]

Background: Acute kidney injury (AKI) is common among cardiac arrest survivors. However, the outcomes and predictors are not well studied. Methods: This is a cohort study of cardiac arrest patients enrolled from January 2012 to December 2016 who were able to survive for 24 hours post-cardiopulmonary resuscitation. Patients with anuria, chronic kidney disease (stage 5), and end-stage renal disease were excluded. Acute kidney injury (stage 1) or higher was defined using Kidney Disease: Improving Global Outcomes classification. Multivariable adjusted regression models were used to compute hazard ratio (HR) for association of AKI with risk of mortality and odds ratio (OR) with risk of poor neurological outcomes after adjusting for demographics, comorbidities, and medical therapy. Multivariable logistic regression model was used to compute OR for association of various predictors with AKI. Results: Of 842 cardiac arrest survivors, 588 (69.8%) developed AKI. Among AKI patients, 69.4% died compared with 52.0% among non-AKI patients. In multivariable adjusted Cox proportional hazard model, development of AKI post-cardiac arrest was significantly associated with mortality (HR: 1.35; 95% confidence interval [CI]: 1.07-1.71, P = .01) and poor neurological outcomes defined as cerebral performance category >2 (OR: 2.27; 95% CI: 1.45-3.57, P < .001) and modified Rankin scale >3 (OR: 2.22; 95% CI: 1.43-3.45, P < .001). Postdischarge dialysis was also associated with increased risk of mortality (HR: 2.57; 95% CI: 1.57-4.23, P < .001). Use of vasopressors was strongly associated with development of AKI and continued need for postdischarge dialysis. Conclusions: Acute kidney injury was associated with increased risk of mortality and poor neurological outcomes. There is need for further studies to prevent AKI in cardiac arrest survivors. [ABSTRACT FROM AUTHOR]

Three 4-amino-1,8-naphthalimide analogues were synthesized, consisting of the tridentate chelators di-2-picolylamine, (pyridin-2-ylmethyl)glycinate, and iminodiacetate conjugated to the naphthalimide scaffold. Coordination with fac-99mTc/Re(CO)3 resulted in metal complexes with overall charges of −1, 0, or +1. Upon coordination of Re(I), the initial naphthalimide-based fluorescence is largely maintained for both negative and neutral complexes compared to their free ligand forms, while an increase in fluorescence quantum yield was observed for the positively charged complex. OVCAR-8 ovarian cancer cells were stained with each of the complexes, demonstrating that the positive complex is more lipophilic and cell membrane permeable than the neutral and negative complexes. Each of the three technetium-99m labelled naphthalimide complexes were successfully produced from fac-[99mTc(CO)3(H2O)3]+ in 15 minutes at 70 °C and isolated in radiochemical yields ranging from 60–95% with radiochemical purities greater than 95%. These fluorescent metal complexes of various charges can be used to tune pharmacokinetic and cellular uptake properties of 99mTc/Re-naphthalimide-bioconjugates, while still maintaining desirable fluorescence properties. [ABSTRACT FROM AUTHOR]

Background: The objective of the current study was to adapt the Index of Dental Anxiety and Fear (IDAF-4C) in the Urdu language and measure its validity and reliability. Methods: Original English questionnaire of IDAF-4C was translated into Urdu language by a panel of dentists and language experts (Urdu and English) followed by critical evaluation, modification and back translation into English language. A final Urdu questionnaire was distributed among 250 patients visiting the Endodontics section at Margalla Institute of Health Sciences (MIHS), Rawalpindi, Pakistan. Cronbach's alpha was used to determine the reliability of the Index whereas validity was assessed by exploratory factor analysis (EFA). Mean rank scores of IDAF-4C for male and female participants were evaluated using Mann-Whitney U tests (P < 0.05). Results: Of 250 questionnaires, 209 were returned with a response rate of 84%. Cronbach's alpha for the Urdu version of IDAF-4C was 0.88. Exploratory factor analysis of the IDAF-4C revealed one factor explaining 55.55% of the common variance (Eigenvalue = 4.5). The mean rank scores of all eight items of IDAF-4C were greater for female participants as compared to male participants with a statistically significant association (P < 0.05). Conclusion: The psychometric analysis of the Urdu version of IDAF-4C showed good reliability and consistency compared to the original version as well as other translated versions. [ABSTRACT FROM AUTHOR]

Early-life experience influences subsequent maturation and function of the adult brain, sometimes even in a sex-specific manner, but underlying molecular mechanisms are poorly understood. We describe here how juvenile experience defines sexually dimorphic synaptic connectivity in the adult Caenorhabditis elegans nervous system. Starvation of juvenile males disrupts serotonin-dependent activation of the CREB transcription factor in a nociceptive sensory neuron, PHB. CREB acts through a cascade of transcription factors to control expression of an atypical cadherin protein, FMI-1/Flamingo/CELSR. During postembryonic development, FMI-1 promotes and maintains synaptic connectivity of PHB to a command interneuron, AVA, in both sexes, but a serotonin-dependent transcriptional regulatory cassette antagonizes FMI-1 expression in males, thereby establishing sexually dimorphic connectivity between PHB and AVA. A critical regulatory node is the CREB-target LIN-29, a Zn finger transcription factor that integrates four layers of information: sexual specificity, past experience, time and cell-type specificity. Our findings provide the mechanistic details of how an early juvenile experience defines sexually dimorphic synaptic connectivity.

Three 4-amino-1,8-naphthalimide analogues were synthesized, consisting of the tridentate chelators di-2-picolylamine, (pyridin-2-ylmethyl)glycinate, and iminodiacetate conjugated to the naphthalimide scaffold. Coordination with fac- 99m Tc/Re(CO) 3 resulted in metal complexes with overall charges of -1, 0, or +1. Upon coordination of Re(i), the initial naphthalimide-based fluorescence is largely maintained for both negative and neutral complexes compared to their free ligand forms, while an increase in fluorescence quantum yield was observed for the positively charged complex. OVCAR-8 ovarian cancer cells were stained with each of the complexes, demonstrating that the positive complex is more lipophilic and cell membrane permeable than the neutral and negative complexes. Each of the three technetium-99m labelled naphthalimide complexes were successfully produced from fac-[ 99m Tc(CO) 3 (H 2 O) 3 ] + in 15 minutes at 70 °C and isolated in radiochemical yields ranging from 60-95% with radiochemical purities greater than 95%. These fluorescent metal complexes of various charges can be used to tune pharmacokinetic and cellular uptake properties of 99m Tc/Re-naphthalimide-bioconjugates, while still maintaining desirable fluorescence properties.