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3. Sound-Induced Flash Illusions Support Cortex Hyperexcitability in Fibromyalgia

Author

Di Stefano, V, Iacono, S, Gagliardo, A, Maggio, B, Guggino, G, Gangitano, M, Monastero, R, Maggio, V, Bolognini, N, Brighina, F, Di Stefano V., Iacono S., Gagliardo A., Maggio B., Guggino G., Gangitano M., Monastero R., Maggio V. R., Bolognini N., Brighina F., Di Stefano, V, Iacono, S, Gagliardo, A, Maggio, B, Guggino, G, Gangitano, M, Monastero, R, Maggio, V, Bolognini, N, Brighina, F, Di Stefano V., Iacono S., Gagliardo A., Maggio B., Guggino G., Gangitano M., Monastero R., Maggio V. R., Bolognini N., and Brighina F.

Abstract

Objectives. Fibromyalgia (FM) is characterized by spontaneous chronic widespread pain in combination with hyperalgesia to pressure stimuli. Sound-induced flash illusions (SIFIs) reflect cross-modal interactions between senses allowing to assess a visual cortical hoerexcitability (VCH) by evaluating the fission and fusion illusions disruption. The aims of the present study were to explore whether SIFIs are perceived differently in patients with fibromyalgia as compared to healthy controls (HCs) and how migraine affects fission and fusion illusions in fibromyalgia. Methods. A single flash (F) accompanied by 0 to 4 beeps (B) was presented to induce the fission illusion while multiple flash (i.e., 2 to 4) accompanied by 0 or 1 beep was presented to induce fusion illusion. The mean number of perceived flashes in fission and fusion illusion trials was compared between the groups (i.e., FM, FM with migraine, and HCs) using repeated-measures analysis of variance. Medication history was recorded along with the administration of Fibromyalgia Impact Questionnaire and Hospital Anxiety and Depression scales. Results. Twenty-four patients with FM (mean age 51, 2 ± 10, 6 years; 22 females), seventeen patients with FM and migraine without aura (mean age 47.8 ± 11.4 years; 16 females; 13 chronic, 4 episodic migraine), and forty-one age- and sex-matched HCs (mean age 47.3 ± 6.9 years; 34 females) participated in the study. Fission and fusion illusory effects were detected in all the participants. However, in FM patients, the fission illusion was reduced and almost abolished as compared to HCs (1F1B, p=0.02; 1F2B, p<0.0001; 1F3B, p<0.0001; 1F4B, p=0.0001), while there were no differences between groups in fusion trials. Migraine did not affect the fission and the fusion illusions. Conclusion. Results from this study confirm that patients with FM have a VCH suggesting that the pathological changes in cortical excitability might have important roles in the pathophysiology of FM. S

Published
2022

7. Preliminary report in treatment of proximal humeral fracture with closed reduction and DOS external fixation System: a multicentric study

Author

Scaravilli G, Mercurio J, Grazioli A, Gioia C, D’Arienzo A, Toro G, Galvano N, Monteleone G, Battaglini G, Di Santo F, Sepe S, Pagliuca S, Cesarano E, Mastrobuono G, Italiano M, D’Arienzo M, Maniscalco P, Ciatti C, Di Maggio B., Scaravilli, G, Mercurio, J, Grazioli, A, Gioia, C, D’Arienzo, A, Toro, G, Galvano, N, Monteleone, G, Battaglini, G, Di Santo, F, Sepe, S, Pagliuca, S, Cesarano, E, Mastrobuono, G, Italiano, M, D’Arienzo, M, Maniscalco, P, Ciatti, C, and Di Maggio, B.

Abstract

Introduction: Proximal humerus fractures are the seventh most frequent fracture in adults, and the third in patients over 65 years old, 5.7% of whole diagnosed fractures. Most of these fractures can be treated conservatively and achieve good results. However, more and more frequently we are confronted with dislo-cated and multifragmentary fractures, and with elderly and high functional demanding patients. In patients with osteoporosis and poor general conditions external fixation can be performed as rapid and mininvasive procedure with good outcome and low complication rates. The authors investigated the use of external fixa-tion in the treatment of proximal humerus fractures. The objective is to demonstrate the effectiveness of this method as a valid alternative to other surgical techniques. Materials and Methods: A multicentre study was conducted at 7 hospitals in Italy from 2014 through 2018. We recruited all proximal humeral fractures (as classified with the Neer system) that are surgically treated with the same external fixator DOS, for a total of 110 patients, evaluated later with Oxford Shoulder Scale (OSS) and disability of the arm, shoulder and hand score (DASH) at 1, 2 and 6 months. Results:The patients have passed from a score of 75,37 in the first month to a score of 29,47in the sixth month at the DASH and from 47,02 to 27,71 at the OSS. The data further confirm the increased incidence of these fractures in women and in a mean age of about 65. Conclusions:Al-though it does not represent the golden standard in the treatment of fractures of the proximal humerus, in our experience the minimal osteosynthesis with external fixator turned out to be a very valid help especially for the simplicity and speed of the method, as well as for the exciting functional results. sometimes superior to other methods. The preliminary results from the different centers have confirmed this hypothesis. We hope this will be a good starting point for further in-depth studies.

Published
2022

12. Protein-mediated surface structuring in biomembranes

Author

Maggio B., Rosetti C.M., Borioli G.A., Fanani M.L., and Del Boca M.

Subjects
Lipid monolayers, Sphingomyelinase, c-Fos, Segregated lipid domains, Lipid-protein interaction, Anphitropic proteins, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

The lipids and proteins of biomembranes exhibit highly dissimilar conformations, geometrical shapes, amphipathicity, and thermodynamic properties which constrain their two-dimensional molecular packing, electrostatics, and interaction preferences. This causes inevitable development of large local tensions that frequently relax into phase or compositional immiscibility along lateral and transverse planes of the membrane. On the other hand, these effects constitute the very codes that mediate molecular and structural changes determining and controlling the possibilities for enzymatic activity, apposition and recombination in biomembranes. The presence of proteins constitutes a major perturbing factor for the membrane sculpturing both in terms of its surface topography and dynamics. We will focus on some results from our group within this context and summarize some recent evidence for the active involvement of extrinsic (myelin basic protein), integral (Folch-Lees proteolipid protein) and amphitropic (c-Fos and c-Jun) proteins, as well as a membrane-active amphitropic phosphohydrolytic enzyme (neutral sphingomyelinase), in the process of lateral segregation and dynamics of phase domains, sculpturing of the surface topography, and the bi-directional modulation of the membrane biochemical reactivity.

Published
2005

15. Monitoring of the radio galaxy M 87 during a low-emission state from 2012 to 2015 with MAGIC

Author

Acciari, V A, Ansoldi, Antonelli, S, L A, Arbet&nbsp, Engels, Arcaro, A, Baack, C, Babić, D, Banerjee, A, Bangale, B, Barres&nbsp, de&nbsp, Almeida, P, Barrio, U, J A, Becerra&nbsp, González, Bednarek, J, Bellizzi, W, Bernardini, L, Berti, E, Besenrieder, A, Bhattacharyya, J, Bigongiari, W, Biland, C, Blanch, A, Bonnoli, O, Bošnjak, G, Busetto, Ž, Carosi, G, Ceribella, R, Chai, G, Chilingaryan, Y, Cikota, A, Colak, S, S M, Colin, Colombo, U, Contreras, E, J L, Cortina, Covino, J, D’Elia, S, Da&nbsp, Vela, V, Dazzi, P, De&nbsp, Angelis, F, Lotto, A, Delfino, B, Delgado, M, Depaoli, J, Di&nbsp, Pierro, D, Venere, F, Do&nbsp, Souto&nbsp, Espiñeira, L, Dominis&nbsp, Prester, E, Donini, D, Dorner, A, Doro, D, Elsaesser, M, Fallah&nbsp, Ramazani, D, Fattorini, V, Fernández-Barral, A, Ferrara, A, Fidalgo, G, Foffano, D, Fonseca, L, M V, Font, Fruck, L, Fukami, C, García&nbsp, López, S, R J, Garczarczyk, Gasparyan, M, Gaug, S, Giglietto, M, Giordano, N, Godinović, F, Green, N, Guberman, D, Hadasch, D, Hahn, D, Herrera, A, Hoang, J, Hrupec, J, Hütten, D, Inada, M, Inoue, T, Ishio, S, Iwamura, K, Jouvin, Y, Kerszberg, L, Kubo, D, Kushida, H, Lamastra, J, Lelas, A, D, Leone, F., Lindfors, E., Lombardi, Longo, S, López, F, López-Coto, M, López-Oramas, R, Loporchio, A, Machado&nbsp, Oliveira&nbsp, Fraga, S, Maggio, B, Majumdar, C, Makariev, P, Mallamaci, M, Maneva, M, Manganaro, G, Mannheim, M, Maraschi, K, Mariotti, L, Martínez, M, Masuda, M, Mazin, S, Mićanović, D, Miceli, S, Minev, D, Miranda, M, J M, Mirzoyan, Molina, R, Moralejo, E, Morcuende, A, Moreno, D, Moretti, V, Munar-Adrover, E, Neustroev, P, Nigro, V, Nilsson, C, Ninci, K, Nishijima, D, Noda, K, Nogués, K, Nöthe, L, Nozaki, M, Paiano, S, Palacio, S, Palatiello, J, Paneque, M, Paoletti, D, Paredes, R, Peñil, Peresano, P, Persic, M, Prada&nbsp, Moroni, M, P G, Prandini, Puljak, E, Rhode, I, Ribó, W, Rico, M, Righi, J, Rugliancich, C, Saha, A, Sahakyan, L, Saito, N, Sakurai, T, Satalecka, S, Schmidt, K, Schweizer, K, Sitarek, T, Šnidarić, J, Sobczynska, I, Somero, D, Stamerra, A, Strom, A, Strzys, D, Suda, M, Surić, Y, Takahashi, T, Tavecchio, M, Temnikov, F, Terzić, P, Teshima, T, Torres-Albà, M, Tosti, N, Tsujimoto, L, Vagelli, S, van&nbsp, Scherpenberg, V, Vanzo, J, Acosta, G, M Vazquez, Vigorito, C F, Vitale, Vovk, V, Will, I, Zarić, M, Asano, D, Collaborators: K, Hada, Harris, K, D E, Giroletti, Jermak, M, H E, Madrid, J P, Massaro, Richter, F, Spanier, S, Steele, F, I A, Walker, R, C, European Space Agency, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), National Aeronautics and Space Administration (US), Agencia Estatal de Investigación (España), European Commission, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Arcaro, C., Baack, D., Babic, A., Banerjee, B., Bangale, P., Barres de Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., da Vela, P., Dazzi, F., de Angelis, A., de Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Tsujimoto, S., Vagelli, V., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., Asano, K., Hada, K., Harris, D. E., Giroletti, M., Jermak, H. E., Madrid, J. P., Massaro, F., Richter, S., Spanier, F., Steele, I. A., Walker, R. C., 30588766 - Arcaro, Cornelia, 25433822 - Richter, Stephan, and 25161814 - Spanier, Felix Alexander

Subjects
galaxies [Gamma rays], Photon, Radio galaxy, VHE [gamma ray], radiation mechanisms non-thermal, galaxies active, galaxies individual M 87, galaxies jets, gamma rays galaxies, magnetic field, Astrophysics, jet [Galaxies], 01 natural sciences, Power law, law.invention, galaxies: individual: M 87, law, flux [gamma ray], radiation mechanisms: non-thermal, galaxies: active, galaxies: jets, gamma rays: galaxies, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics, QC, QB, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Physics, galaxie [Gamma rays], photon, Synchrotron, Magnetic field, Wavelength, Galaxies: active, Galaxies: individual: M 87, Galaxies: jets, Gamma rays: galaxies, Radiation mechanisms: non-thermal, Spectral energy distribution, Astrophysics and Astronomy, active [Galaxies], Astrophysics::High Energy Astrophysical Phenomena, radio wave [galaxy], FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, GLAST, GeneralLiterature_MISCELLANEOUS, Telescope, emission [gamma ray], synchrotron, 0103 physical sciences, Astrophysics::Galaxy Astrophysics, non-thermal [Radiation mechanisms], hybrid, 010308 nuclear & particles physics, ComputingMilieux_PERSONALCOMPUTING, individual: M 87 [galaxies], Astronomy and Astrophysics, MAGIC, monitoring, Space and Planetary Science, ddc:520, spectral, jets [Galaxies], individual: M 87 [Galaxies], non-thermal [adiation mechanisms]
Abstract

MAGIC Collaboration: et al., M 87 is one of the closest (z = 0.004 36) extragalactic sources emitting at very high energies (VHE, E > 100 GeV). The aim of this work is to locate the region of the VHE gamma-ray emission and to describe the observed broad-band spectral energy distribution (SED) during the low VHE gamma-ray state. The data from M 87 collected between 2012 and 2015 as part of a MAGIC monitoring programme are analysed and combined with multiwavelength data from Fermi-LAT, Chandra, HST, EVN, VLBA, and the Liverpool Telescope. The averaged VHE gamma-ray spectrum can be fitted from ∼100 GeV to ∼10 TeV with a simple power law with a photon index of (−2.41 ± 0.07), while the integral flux above 300 GeV is (1.44±0.13)×10−12cm−2s−1⁠. During the campaign between 2012 and 2015, M 87 is generally found in a low-emission state at all observed wavelengths. The VHE gamma-ray flux from the present 2012–2015M 87 campaign is consistent with a constant flux with some hint of variability (⁠∼3σ⁠) on a daily time-scale in 2013. The low-state gamma-ray emission likely originates from the same region as the flare-state emission. Given the broad-band SED, both a leptonic synchrotron self-Compton and a hybrid photohadronic model reproduce the available data well, even if the latter is preferred. We note, however, that the energy stored in the magnetic field in the leptonic scenario is very low, suggesting a matter-dominated emission region., The financial support of the German BMBF and MPG, the Italian Istituto Nazionale di Fisica Nucleare (INFN) and Istituto Nazionale di Astrofisica (INAF), the Swiss National Fund (SNF), the ERDF under the Spanish Ministry of Economy and Competitiveness (MINECO) (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, and the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia ‘Severo Ochoa’ SEV-2016-0588 and SEV2015-0548, and Unidad de Excelencia ‘Maria de Maeztu’ MDM2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers grants SFB823/C4 and SFB876/C3, by the Polish National Research Centre grant UMO2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq, and FAPERJ. The Very Long Baseline Array is operated by the National Radio Astronomy Observatory, which is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. The work of FM is supported by the ‘Departments of Excellence 2018–2022’ Grant awarded by the Italian Ministry of Education, University and Research (MIUR) (L. 232/2016). His research has made also use of resources provided by the Compagnia di San Paolo for the grant awarded on the BLENV project (S1618 L1 MASF 01) and by the Ministry of Education, Universities and Research for the grant MASF FFABR 17 01. This investigation is supported by the National Aeronautics and Space Administration (NASA) grants GO4-15096X, AR6-17012X, and GO6-17081X. This work made use of the Swinburne University of Technology software correlator, developed as part of the Australian Major National Research Facilities Programme and operated under licence. Based in part on observations made with the NASA/European Space Agency (ESA) Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. These observations are associated with programmes GO 12293, 12671, 13061, and 13759.

Published
2020

16. Second primary neoplasms in patients with lung and gastroenteropancreatic neuroendocrine neoplasms: Data from a retrospective multi-centric study

Author

Massironi, S., Campana, D., Pusceddu c, S., Albertelli, M., Faggiano e, A., Panzuto f, F., Smiroldo g, V., Andreasi h, V., Rossi i, R. E., Maggio b, I., Torchio c, M., Dotto, A., Modica j, R., Rinzivillo f, M., Carnaghi k, C., Partelli h, S., Fanetti l, I., Lamberti b, G., Corti c, F., Ferone, D., Colao j, A., Annibale f, B., M, Invernizzi a, P., Falconi h, M., and ItaNet (Italian Association for Neuroendocrine Tumours) Study Group

Published
2020

19. Sintesi e valutazione biologica di nuovi nitroderivati analoghi della pirrolomicina D attivi su Pseudomonas aeruginosa

Author

Agnese, R., Cusimano, M., Plescia, F., Maggio, B., Daidone, G., Raffa, D., LA FRANCA, M., LI PETRI, G., Ornella, R., Roberta, L., Barone, G., Schillaci, D., and Raimondi, M.

Subjects
Pirrolomina D, Pseudomonas aeruginosa, MIC, Settore CHIM/03 - Chimica Generale E Inorganica, Settore BIO/19 - Microbiologia Generale, Settore CHIM/08 - Chimica Farmaceutica
Published
2018

21. Synthesized benzamido derivatives exert antiproliferative effects by DNA damage and ROS generation

Author

D’Anneo, A., Raffa, D., Plescia, F., Maggio, B., Raimondi, M., Daidone, G., Lauricella, M., D’Anneo, A, Raffa, D, Plescia, F, Maggio, B, Raimondi, MV, Daidone, G, and Lauricella, M.

Subjects
anti-proliferative effect, DNA damage, benzamido derivatives, ROS, anti-proliferative effects
Abstract

In this study we explored the effect and the biological action of synthesized benzamido derivatives bearing the (1S,2S)-2-phenyl-cyclopropane-1-carboxamido, 1,1'-biphen-2-carboxamido and 1,1'-biphen-4-carboxamido moieties on K562, a human leukemia cell line. Among the synthesized compounds a particular antiproliferative action was observed with the benzamido derivative bearing the 2-1,1'-biphenyl moiety with the substitution at the 5 position of the benzamido moiety with iodine. This compound showed cytotoxic effects in K562 leukemic cells at nanomolar concentrations and was, therefore, chosen as compound to explore its mode of action. Our analyses provided evidence that this benzamido derivative induced a reduction in cell number and volume with the appearance of a shrunken cytoplasm at 24h, followed by a widespread cell fragmentation at 48h. As demonstrated by flow cytometry analyses, the effect was dose- and time-dependent, causing a G2/M cell cycle arrest in the first phase of treatment (24h), followed by an apoptotic death at 48h (IC50 0.5 μM ). The elucidation of the underlying mechanism also disclosed that DNA arrest in G2/M phase of cell cycle was consequent to DNA lesions, since an increase in phospho-ATM and yH2AX, two known markers of DNA repair response system, was observed. Prolonging the time of treatment, the effects, which were observed only in leukaemic cells but not in normal bronchial epithelial cells, were accompanied by ROS production, JNK phosphorylation and induction of a caspase-dependent apoptosis.

Published
2016

22. A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

Author

Benedetti, M, Pugliatti, M, Dalessandro, R, BEGHI, ETTORE, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Raschetti, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, AM, Borsato, C, Bortolotto, S, Bottacchi, EF, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, SI, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, AM, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, NA, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, FERRARESE, CARLO, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, DM, Passarella, B, Pavesi, G, Penza, MT, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, GM, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, MR, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., Benedetti, Md, Pugliatti, M, D'Alessandro, R, Beghi, E, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Comi, Giancarlo, Raschetti, R, ITANG Study, Group, Giometto, B, Benedetti, M, Dalessandro, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, A, Borsato, C, Bortolotto, S, Bottacchi, E, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, S, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, A, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, N, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, D, Passarella, B, Pavesi, G, Penza, M, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, G, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, M, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, and Zoccolella, S

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Epidemiology, Population, Guillain-Barre Syndrome, Rate ratio, NO, Young Adult, Axonal and demyelinating GBS, Guillain-Barré syndrome, Incidence, Prospective study, Trend, Neurology (clinical), Aged, Aged, 80 and over, Female, Humans, Italy, Middle Aged, 80 and over, medicine, Young adult, education, Prospective cohort study, education.field_of_study, Guillain-Barre syndrome, business.industry, Medicine (all), Incidence (epidemiology), medicine.disease, Vaccination, Settore MED/26 - NEUROLOGIA, business, Human
Abstract

Background: To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Published
2015

26. NUOVI DERIVATI 2-ACETAMMIDOBENZAMMIDICI: ATTIVITÀ ANTIPROLIFERATIVA E POSSIBILE MECCANISMO DI AZIONE

Author

Cascioferro, S., Raffa, D., Maggio, B., Plescia, F., Raimondi, M., Bai, R., Hamel, E., Daidone, G., Cascioferro, S, Raffa, D, Maggio, B, Plescia, F, Raimondi, MV, Bai, R, Hamel, E, and Daidone,G

Subjects
Settore CHIM/08 - Chimica Farmaceutica, cinnammido benzammidi, antitumorali, microtubuli
Abstract

Le cinnammido benzammidi rappresentano una classe di sostanze biologicamente attive di grande interesse farmaceutico. Nonostante siano state descritte per svariate attività biologiche, nessun dato è stato riportato sulla loro attivita antitumorale. Inizialmente una serie di 2-cinammidobenzammidi variamente sostituite sono state sintetizzate e valutate per la loro attività antiproliferativa. Partendo dal derivato risultato più attivo, il 2-cinnammido-5-iodobenzammide, che ha mostrato una percentuale di inibizione della crescita sulle K562 del 74% a 10μM, sono stati sintetizzati una serie di derivati al fine di approfondirne la SAR.I composti così ottenuti sono risultati attivi nei confronti di numerose linee cellulari tumorali a concentrazioni micromolari e submicromololari inducendo un blocco del ciclo cellulare delle K562 in fase G2M. Inoltre i derivati sintetizzati sono in grado di indurre apoptosi nelle cellule HEP G2.

Published
2014

27. Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives

Author

Maggio, B., Cancemi, G., Raimondi, M., Plescia, F., Cascioferro, S., Cusimano, M., Lauricella, M., Carlisi, D., Daidone, G., Raffa, D., Maggio, B, Cancemi, G, Raimondi, MV, Plescia, F, Cascioferro, SM, Cusimano, MG, Lauricella, M, Carlisi, D, Daidone, G, and Raffa, D

Subjects
Settore BIO/10 - Biochimica, isoxazolo[3,4-d]pyridazin-7(6H)-ones, antiproliferative activity, DNA interaction, Settore CHIM/08 - Chimica Farmaceutica
Abstract

3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.

Published
2014

29. A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study

Author

Benedetti, M. D., Pugliatti, M., Dalessandro, R., Beghi, E., Chio, A., Logroscino, G., Filippini, G., Galeotti, F., Massari, M., Santuccio, C., Raschetti R., Abruzzi L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, Am, Borsato, C, Bortolotto, S, Bottacchi, Ef, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, Si, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, Am, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, Na, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, Eugenio, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile-Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, Dm, Passarella, B, Pavesi, G, Penza, Mt, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, Gm, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, Mg, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, Mr, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., Magni E (ORCID:0000-0002-2235-2280), Benedetti, M. D., Pugliatti, M., Dalessandro, R., Beghi, E., Chio, A., Logroscino, G., Filippini, G., Galeotti, F., Massari, M., Santuccio, C., Raschetti R., Abruzzi L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, Am, Borsato, C, Bortolotto, S, Bottacchi, Ef, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, Si, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, Am, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, Na, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, Eugenio, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile-Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, Dm, Passarella, B, Pavesi, G, Penza, Mt, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, Gm, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, Mg, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, Mr, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., and Magni E (ORCID:0000-0002-2235-2280)

Abstract

To assess Guillain-Barre syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Published
2015

31. Immune Response and Candidal Colonisation in Denture Associated Stomatitis

Author

Maggio B, David Wynne Williams, Ankur Gupta, Walker Rv, Lewis Mao, Wei X-Q, Jeremy Simon Rees, Helen Rogers, and Patel

Subjects
Colonisation, medicine.anatomical_structure, Immune system, Regulatory T cell, Cytokine profile, Immunology, medicine, Bead array, Biology, medicine.disease, Stomatitis, PALATAL INFLAMMATION
Abstract

Denture stomatitis (DS) is an inflammatory oral condition affecting most frequently the palatal mucosa covered by the fitting surface of a denture. The aim of this study was to determine the local cytokine profile generated in DS, as well as the level and identity of Candida involved. Palatal inflammation was determined by clinical indices in 93 upper denture-wearing subjects (42 with DS). The level of selected cytokines in palatal fluid was measured by cytometric bead array. Grouping of the cytokines associated with Th1, Th2, Th17 and regulatory T cell (Treg) responses, showed significant increases particularly for Th1 and Th17 responses. Using imprint culture, Candida was isolated from 48 patients (29 with DS). DS patients had significantly higher numbers of Candida isolated from the fitting surface of the denture (P=0.0113). However, there was significantly (P=0.03) higher numbers of Candida on the palate of non-DS patients. In summary, it would appear that an appropriate immune response is elicited in DS patients and whilst this appears to reduce Candida levels on inflamed mucosa, it is probable that Candida on the fitting surface of the denture remain protected from local immune responses which results in a continued reservoir of infection.

Published
2013

40. Pyrazolobenzotriazinone derivatives as COX inhibitors: synthesis, biological activity, and molecular-modeling studies.

Author

Raffa, D, Migliara, O, Maggio, B, Plescia, F, Cascioferro, S, Cusimano, Mg, Tringali, Giuseppe, Cannizzaro, C, Plescia, F., Tringali, Giuseppe (ORCID:0000-0002-1030-9429), Raffa, D, Migliara, O, Maggio, B, Plescia, F, Cascioferro, S, Cusimano, Mg, Tringali, Giuseppe, Cannizzaro, C, Plescia, F., and Tringali, Giuseppe (ORCID:0000-0002-1030-9429)

Abstract

Pyrazolylbenzotriazinones are endowed with a structural analogy with the COX-2 selective inhibitor celecoxib. Considering that our research group has long been interested in the 3-pyrazolyl-substituted benzotriazinones as anti-inflammatory agents, six new pyrazolylbenzotriazinone derivatives 16a-c and 18a-c have been prepared by reacting the opportune ethyl 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate or 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxyic acid with sodium nitrite in glacial acetic acid. The biological studies revealed a good pharmacological profile for some pyrazolylbenzotriazinones and, in the case of the ethyl 5-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-pyridin-2-yl-1H-pyrazole-4-carboxylate, a good COX-1/COX-2 selectivity. Molecular modeling studies confirmed the obtained biological results.

Published
2010

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