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1,145 results on '"Mackay, Mark"'

1. Probabilistic emotion and sentiment modelling of patient-reported experiences

Author

Murray, Curtis, Mitchell, Lewis, Tuke, Jonathan, and Mackay, Mark

Subjects
Computer Science - Computation and Language
Abstract

This study introduces a novel methodology for modelling patient emotions from online patient experience narratives. We employed metadata network topic modelling to analyse patient-reported experiences from Care Opinion, revealing key emotional themes linked to patient-caregiver interactions and clinical outcomes. We develop a probabilistic, context-specific emotion recommender system capable of predicting both multilabel emotions and binary sentiments using a naive Bayes classifier using contextually meaningful topics as predictors. The superior performance of our predicted emotions under this model compared to baseline models was assessed using the information retrieval metrics nDCG and Q-measure, and our predicted sentiments achieved an F1 score of 0.921, significantly outperforming standard sentiment lexicons. This method offers a transparent, cost-effective way to understand patient feedback, enhancing traditional collection methods and informing individualised patient care. Our findings are accessible via an R package and interactive dashboard, providing valuable tools for healthcare researchers and practitioners., Comment: 23 pages, 10 figures, 5 tables

Published
2024

2. Revealing Patient-Reported Experiences in Healthcare from Social Media using the DAPMAV Framework

Author

Murray, Curtis, Mitchell, Lewis, Tuke, Jonathan, and Mackay, Mark

Subjects
Computer Science - Computation and Language
Abstract

Understanding patient experience in healthcare is increasingly important and desired by medical professionals in a patient-centered care approach. Healthcare discourse on social media presents an opportunity to gain a unique perspective on patient-reported experiences, complementing traditional survey data. These social media reports often appear as first-hand accounts of patients' journeys through the healthcare system, whose details extend beyond the confines of structured surveys and at a far larger scale than focus groups. However, in contrast with the vast presence of patient-experience data on social media and the potential benefits the data offers, it attracts comparatively little research attention due to the technical proficiency required for text analysis. In this paper, we introduce the Design-Acquire-Process-Model-Analyse-Visualise (DAPMAV) framework to provide an overview of techniques and an approach to capture patient-reported experiences from social media data. We apply this framework in a case study on prostate cancer data from /r/ProstateCancer, demonstrate the framework's value in capturing specific aspects of patient concern (such as sexual dysfunction), provide an overview of the discourse, and show narrative and emotional progression through these stories. We anticipate this framework to apply to a wide variety of areas in healthcare, including capturing and differentiating experiences across minority groups, geographic boundaries, and types of illnesses., Comment: 25 pages, 8 figures, 4 tables

Published
2022

5. A quantitative EEG index for the recognition of arterial ischemic stroke in children

Author

Armstrong, Jennifer, Chavez, Marta, deVeber, Gabrielle, Dlamini, Noma, Dowling, Michael, Felling, Ryan, Fullerton, Heather, Guilliams, Kristin, Hassanein, Sahar, Jordan, Lori, Kirton, Adam, Lefond, Catherine, Lehman, Laura, Mackay, Mark, Pergami, Paola, Rafay, Mubeen, Tatishvili, Nana, Victorio, Maria, Caffarelli, Mauro, Karukonda, Vishnu, Aghaeeaval, Mahsa, McQuillen, Patrick S., Numis, Adam L., Mackay, Mark T., Press, Craig A., Wintermark, Max, Fox, Christine K., and Amorim, Edilberto

Published
2023
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7. Symptom extraction from the narratives of personal experiences with COVID-19 on Reddit

Author

Murray, Curtis, Mitchell, Lewis, Tuke, Jonathan, and Mackay, Mark

Subjects
Computer Science - Computation and Language, Computer Science - Social and Information Networks, Statistics - Applications
Abstract

Social media discussion of COVID-19 provides a rich source of information into how the virus affects people's lives that is qualitatively different from traditional public health datasets. In particular, when individuals self-report their experiences over the course of the virus on social media, it can allow for identification of the emotions each stage of symptoms engenders in the patient. Posts to the Reddit forum r/COVID19Positive contain first-hand accounts from COVID-19 positive patients, giving insight into personal struggles with the virus. These posts often feature a temporal structure indicating the number of days after developing symptoms the text refers to. Using topic modelling and sentiment analysis, we quantify the change in discussion of COVID-19 throughout individuals' experiences for the first 14 days since symptom onset. Discourse on early symptoms such as fever, cough, and sore throat was concentrated towards the beginning of the posts, while language indicating breathing issues peaked around ten days. Some conversation around critical cases was also identified and appeared at a roughly constant rate. We identified two clear clusters of positive and negative emotions associated with the evolution of these symptoms and mapped their relationships. Our results provide a perspective on the patient experience of COVID-19 that complements other medical data streams and can potentially reveal when mental health issues might appear.

Published
2020

8. A Prospective Multicenter Registry on Feasibility, Safety, and Outcome of Endovascular Recanalization in Childhood Stroke (Save ChildS Pro)

Author

Sporns, Peter B, Kemmling, André, Lee, Sarah, Fullerton, Heather, Kunz, Wolfgang G, Wilson, Jenny L, Mackay, Mark T, Steinlin, Maja, Fiehler, Jens, Psychogios, Marios, and Wildgruber, Moritz

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Clinical Research, Pediatric, Clinical Trials and Supportive Activities, Stroke, Brain Disorders, stroke, ischemic stroke, arterial ischemic stroke, thrombectomy, mechanical thrombectomy, intravenous thrombolysis, childhood stroke, pediatric stroke, Psychology, Clinical sciences, Biological psychology
Abstract

Rationale: Early evidence for the benefit of mechanical thrombectomy (MT) in pediatric patients with intracranial large vessel occlusion has been shown in previous retrospective cohorts. Higher-level evidence is needed to overcome the limitations of these studies such as the lack of a control group and the retrospective design. Randomized trials will very likely not be feasible, and several open questions remain, for example, the impact of arteriopathic etiologies or a possible lower age limit for MT. Save ChildS Pro therefore aims to demonstrate the safety and effectiveness of MT in pediatric patients compared to the best medical management and intravenous thrombolysis. Design: Save ChildS Pro is designed as a worldwide multicenter prospective registry comparing the safety and effectiveness of MT to the best medical care alone in the treatment of pediatric arterial ischemic stroke (AIS). It will include pediatric patients (

Published
2021

9. Spectrum of cerebral arteriopathies in children with arterial ischemic stroke.

Author

Rafay, Mubeen F, Shapiro, Kevin A, Surmava, Ann-Marie, deVeber, Gabrielle A, Kirton, Adam, Fullerton, Heather J, Amlie-Lefond, Catherine, Weschke, Bernhard, Dlamini, Nomazulu, Carpenter, Jessica L, Mackay, Mark T, Rivkin, Michael, Linds, Alexandra, and Bernard, Timothy J

Subjects
Neurosciences, Stroke, Clinical Research, Brain Disorders, Pediatric, Adolescent, Age of Onset, Aneurysm, Dissecting, Anticoagulants, Brain Ischemia, Cerebral Arterial Diseases, Cerebral Infarction, Child, Child, Preschool, Female, Fibrinolytic Agents, Global Health, Headache, Humans, Infant, Infant, Newborn, Intracranial Aneurysm, Male, Prospective Studies, Recurrence, Registries, Risk Factors, Treatment Outcome, Vasculitis, Central Nervous System, International Pediatric Stroke Study (IPSS) Group, Aortic Dissection, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveTo determine that children with arterial ischemic stroke (AIS) due to an identifiable arteriopathy are distinct from those without arteriopathy and that each arteriopathy subtype has unique and recognizable clinical features.MethodsWe report a large, observational, multicenter cohort of children with AIS, age 1 month to 18 years, enrolled in the International Pediatric Stroke Study from 2003 to 2014. Clinical and demographic differences were compared by use of the Fisher exact test, with linear step-up permutation min-p adjustment for multiple comparisons. Exploratory analyses were conducted to evaluate differences between cases of AIS with and without arteriopathy and between arteriopathy subtypes.ResultsOf 2,127 children with AIS, 725 (34%) had arteriopathy (median age 7.45 years). Arteriopathy subtypes included dissection (27%), moyamoya (24.5%), focal cerebral arteriopathy-inflammatory subtype (FCA-i; 15%), diffuse cerebral vasculitis (15%), and nonspecific arteriopathy (18.5%). Children with arteriopathic AIS were more likely to present between 6 and 9 years of age (odds ratio [OR] 1.93, p = 0.029) with headache (OR 1.55, p = 0.023), multiple infarctions (OR 2.05, p < 0.001), sickle cell anemia (OR 2.9, p = 0.007), and head/neck trauma (OR 1.93, p = 0.018). Antithrombotic use and stroke recurrence were higher in children with arteriopathy. Among arteriopathy subtypes, dissection was associated with male sex, older age, headache, and anticoagulant use; FCA-i was associated with hemiparesis and single infarcts; moyamoya was associated with seizures and recurrent strokes; and vasculitis was associated with bilateral infarctions.ConclusionSpecific clinical profiles are associated with cerebral arteriopathies in children with AIS. These observations may be helpful indicators in guiding early diagnosis and defining subgroups who may benefit most from future therapeutic trials.

Published
2020

10. Seizures and Outcome One Year After Neonatal and Childhood Cerebral Sinovenous Thrombosis

Author

Mineyko, Aleksandra, Kirton, Adam, Billinghurst, Lori, Tatishvili, Nana Nino, Wintermark, Max, deVeber, Gabrielle, Fox, Christine, Investigators, SIPS, Abdalla, Abdalla, Zafeiriou, Dimitrios, Friedman, Neil, Aprasidze, Tatia, Kolk, Anneli, Armstrong, Jennifer, Ichord, Rebecca, Amlie-Lefond, Kovacevic, Gordana, Chavez, Marta Hernandez, Mackay, Mark, Titomanlio, Luigi, Guilliams, Kristin, Elbers, Jorina, Fullerton, Heather, Benedict, Susan, Dowling, Michael, Jordan, Lori, and Pergami, Paola

Subjects
Paediatrics, Biomedical and Clinical Sciences, Neurosciences, Minority Health, Neurodegenerative, Brain Disorders, Cerebrovascular, Pediatric, Clinical Research, Stroke, Epilepsy, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Childhood Injury, Hematology, 2.1 Biological and endogenous factors, 4.2 Evaluation of markers and technologies, Neurological, Adolescent, Anticonvulsants, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Ischemic Stroke, Male, Outcome Assessment, Health Care, Seizures, Sinus Thrombosis, Intracranial, Pediatric stroke, Cerebral sinovenous thrombosis, Outcomes, SIPS Investigators, Paediatrics and Reproductive Medicine, Neurology & Neurosurgery
Abstract

BackgroundPediatric cerebral sinovenous thrombosis is a treatable cause of brain injury, acute symptomatic seizures, and remote epilepsy. Our objective was to prospectively study epilepsy and outcomes in neonates and children one year after cerebral sinovenous thrombosis diagnosis.MethodsPatients with cerebral sinovenous thrombosis were enrolled prospectively from 21 international sites through the Seizures in Pediatric Stroke Study. Clinical data, including acute symptomatic seizures and cerebral sinovenous thrombosis risk factors, were collected at diagnosis. A neuroradiologist who was unaware of the diagnosis reviewed acute imaging. At one year, outcomes including seizure recurrence, epilepsy diagnosis, antiepileptic drug use, and modified Engel score were collected. Outcomes were assessed using the modified Rankin score and the King's Outcome Scale for Childhood Head Injury.ResultsTwenty-four participants with cerebral sinovenous thrombosis were enrolled (67% male, 21% neonates). Headache was the most common presenting symptom in non-neonates (47%, nine of 19). Nine (37.5%) presented with acute symptomatic seizures. Six (25%; 95% confidence interval, 10% to 47%) developed epilepsy by one-year follow-up. No clinical predictors associated with epilepsy were identified. King's Outcome Scale for Childhood Head Injury and modified Rankin scores at one year were favorable in 71%. Half of the patients who developed epilepsy (three of six) did not have infarcts, hemorrhage, or seizures identified during the acute hospitalization.ConclusionOur study provides a prospective estimate that epilepsy occurs in approximately one-quarter of patients by one year after diagnosis of cerebral sinovenous thrombosis. Later epilepsy can develop in the absence of acute seizures or parenchymal injury associated with the acute presentation.

Published
2020

11. Comparative study of posterior and anterior circulation stroke in childhood: Results from the International Pediatric Stroke Study.

Author

Goeggel Simonetti, Barbara, Rafay, Mubeen F, Chung, Melissa, Lo, Warren D, Beslow, Lauren A, Billinghurst, Lori L, Fox, Christine K, Pagnamenta, Alberto, Steinlin, Maja, and Mackay, Mark T

Subjects
Neurosciences, Pediatric, Clinical Research, Stroke, Brain Disorders, Adolescent, Brain Ischemia, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Risk Factors, IPSS Study Group, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveTo compare risk factors, clinical presentation, and outcomes after posterior circulation arterial ischemic stroke (PCAIS) and anterior circulation arterial ischemic stroke (ACAIS) in neonates and children.MethodsIn this international multicenter observational study including neonates and children up to 18 years of age with arterial ischemic stroke (AIS), we compared clinical and radiologic features according to stroke location.ResultsOf 2,768 AIS cases, 507 (18%) were located in the posterior circulation, 1,931 (70%) in the anterior circulation, and 330 (12%) involved both. PCAIS was less frequent in neonates compared to children (8.8% vs 22%, p < 0.001). Children with PCAIS were older than children with ACAIS (median age 7.8 [interquartile range (IQR) 3.1-14] vs 5.1 [IQR 1.5-12] years, p < 0.001), and more often presented with headache (54% vs 32%, p < 0.001) and a lower Pediatric NIH Stroke Scale score (4 [IQR 2-8] vs 8 [IQR 3-13], p = 0.001). Cervicocephalic artery dissections (CCAD) were more frequent (20% vs 8.5%, p < 0.001), while cardioembolic strokes were less frequent (19% vs 32%, p < 0.001) in PCAIS. Case fatality rates were equal in both groups (2.9%). PCAIS survivors had a better outcome (normal neurologic examination at hospital discharge in 29% vs 21%, p = 0.002) than ACAIS survivors, although this trend was only observed in children and not in neonates.ConclusionPCAIS is less common than ACAIS in both neonates and children. Children with PCAIS are older and have a higher rate of CCAD, lower clinical stroke severity, and better outcome than children with ACAIS.

Published
2020

12. Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials

Author

Osborne, John P., Edwards, Stuart W., Alber, Fabienne Dietrich, Hancock, Eleanor, Johnson, Anthony L., Kennedy, Colin R., Likeman, Marcus, Lux, Andrew L., Mackay, Mark, Mallick, Andrew, Newton, Richard W., Nolan, Melinda, Pressler, Ronit, Rating, Dietz, Schmitt, Bernhard, Verity, Christopher M., and O'Callaghan, FinbarJ.K.

Published
2023
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14. Building a Career as a Pediatric Stroke Neurologist

Author

Fullerton, Heather J, Ganesan, Vijeya, Jordan, Lori C, Kirton, Adam, Mackay, Mark T, and Steinlin, Maja

Subjects
Biomedical and Clinical Sciences, Allied Health and Rehabilitation Science, Clinical Sciences, Health Sciences, Neurosciences, Career Choice, Humans, Neurologists, Neurology, Pediatrics, Stroke, blood transfusion, pediatrics, risk factors, stroke, thrombophilia, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Published
2019

15. Focal Cerebral Arteriopathy of Childhood

Author

Fullerton, Heather J, Stence, Nicholas, Hills, Nancy K, Jiang, Bin, Amlie-Lefond, Catherine, Bernard, Timothy J, Friedman, Neil R, Ichord, Rebecca, Mackay, Mark T, Rafay, Mubeen F, Chabrier, Stéphane, Steinlin, Maja, Elkind, Mitchell SV, deVeber, Gabrielle A, and Wintermark, Max

Subjects
Allied Health and Rehabilitation Science, Biomedical and Clinical Sciences, Health Sciences, Pediatric, Brain Disorders, Stroke, Neurosciences, Adolescent, Anterior Cerebral Artery, Brain Infarction, Carotid Artery, Internal, Carotid Stenosis, Cerebral Angiography, Cerebral Arterial Diseases, Child, Child, Preschool, Computed Tomography Angiography, Disease Progression, Female, Humans, Infant, Magnetic Resonance Angiography, Male, Middle Cerebral Artery, Posterior Cerebral Artery, Severity of Illness Index, brain ischemia, cerebrovascular disorders, child, follow-up studies, humans, VIPS Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and Purpose- Focal cerebral arteriopathy (FCA)-a common cause of arterial ischemic stroke in previously healthy children-often progresses over days to weeks, increasing the risk of recurrent stroke. We developed a novel severity scoring system designed to quantify FCA progression and correlate with clinical outcomes. Methods- The VIPS study (Vascular Effects of Infection in Pediatric Stroke) prospectively enrolled 355 children with arterial ischemic stroke (2010-2014), including 41 with centrally confirmed FCA. Two neuroradiologists independently reviewed FCA cerebrovascular imaging, assigning a graded severity score of zero (no involvement) to 4 (occlusion) to individual arterial segments. The FCA severity score (FCASS) was the unweighted sum. In an iterative process, we modeled scores derived from different combinations of arterial segments to identify the model that optimized correlation with clinical outcome, simplicity, and reliability. Results- The optimal FCASS summed scores from 5 arterial segments: supraclinoid internal carotid artery, A1, A2, M1, and M2. The median (interquartile range) baseline FCASS was 4 (2-6). Of 33 children with follow-up imaging, the maximum FCASS (at any time point) was 7 (5-9). Twenty-four (73%) had FCA progression on follow-up with their maximum FCASS at a median of 8 (5-35.5) days poststroke; their median FCASS increase was 4 (2.5-6). FCASS did not correlate with recurrent arterial ischemic stroke. Maximum (but not baseline) FCASS correlated with 1-year pediatric stroke outcome measures ( P=0.037). Conclusions- Our novel scoring system for FCA severity correlates with neurological outcomes in the VIPS cohort and provides a tool for FCA treatment trials under development.

Published
2018

18. Childhood stroke

Author

Sporns, Peter B., Fullerton, Heather J., Lee, Sarah, Kim, Helen, Lo, Warren D., Mackay, Mark T., and Wildgruber, Moritz

Published
2022
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20. Children with post-stroke epilepsy have poorer outcomes one year after stroke

Author

Fox, Christine K, Jordan, Lori C, Beslow, Lauren A, Armstrong, Jennifer, Mackay, Mark T, and deVeber, Gabrielle

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Neurosciences, Rehabilitation, Clinical Research, Epilepsy, Stroke, Neurodegenerative, Brain Disorders, Pediatric, Adolescent, Brain Ischemia, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Risk Factors, Young Adult, Ischemic stroke, risk factors, seizures, pediatric, outcomes, neurology, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background Epilepsy is a common complication of pediatric stroke. Aim In this study, we aim to measure the association between epilepsy and neurologic outcome after childhood arterial ischemic stroke. Methods Prospective cohort study of children (29 days-19 years) enrolled after an acute arterial ischemic stroke at 21 international pediatric stroke centers and followed to identify epilepsy. One year post-stroke, outcomes were scored using the examination-based Pediatric Stroke Outcome Measure (range = 0-10); higher values reflect greater disability. Ordinal logistic regression was used to measure the association of Pediatric Stroke Outcome Measure scores (categorized as 0-1, 1.5-3, 3.5-6, 6.5-10) with epilepsy. Results Investigators enrolled 86 children (median age = 6.1 years, interquartile range (IQR) = 1.4-12.2 years) with acute stroke. At 1 year, 18/80 (23%) remained on an anticonvulsant including 8/80 (10%) with epilepsy. Among the 70 with Pediatric Stroke Outcome Measure scored, the median was 0.5 (IQR = 0-1.5) for children without epilepsy ( n = 63), and 6 (IQR = 0.5-10) for children with epilepsy ( n = 7). In univariable analyses, poorer 1-year outcome was associated with middle cerebral artery stroke, cortical infarcts, hemorrhagic transformation, hospital disposition not to home, and epilepsy. In multivariable analysis, middle cerebral artery stroke (odds ratio (OR) = 4.9, 95% confidence intervals (CI) = 1.1-21.3) and epilepsy (OR = 24.1, CI = 1.5-380) remained associated with poorer outcome. Conclusions Children who developed epilepsy during the first year post-stroke had poorer neurologic outcomes than those without epilepsy.

Published
2018

21. Abstract 109: Towards Individualised Prediction of Neurodevelopmental Outcomes After Neonatal Stroke: A Brain Lesion Network Mapping Study Leveraging Large-Scale Datasets

Author

Kelly, Claire, primary, Chen, Jian, additional, Beare, Richard, additional, Stojanovski, Belinda, additional, Grunt, Sebastian, additional, Slavova, Nedelina, additional, Pastore-Wapp, Manuela, additional, Steinlin, Maja I, additional, Mackay, Mark T, additional, and Yang, Joseph, additional

Published
2024
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23. Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Author

Paulson, Katherine R, Kamath, Aruna M, Alam, Tahiya, Bienhoff, Kelly, Abady, Gdiom Gebreheat, Abbas, Jaffar, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Allah, Foad, Abd-Elsalam, Sherief M, Abdoli, Amir, Abedi, Aidin, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Abushouk, Abdelrahman I, Adamu, Aishatu L, Adebayo, Oladimeji M, Adegbosin, Adeyinka Emmanuel, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adeyinka, Daniel Adedayo, Adsuar, Jose C, Afshari, Khashayar, Aghaali, Mohammad, Agudelo-Botero, Marcela, Ahinkorah, Bright Opoku, Ahmad, Tauseef, Ahmadi, Keivan, Ahmed, Muktar Beshir, Aji, Budi, Akalu, Yonas, Akinyemi, Oluwaseun Oladapo, Aklilu, Addis, Al-Aly, Ziyad, Alam, Khurshid, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alcalde-Rabanal, Jacqueline Elizabeth, Al-Eyadhy, Ayman, Ali, Tilahun, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Almasi-Hashiani, Amir, Almasri, Nihad A, Al-Mekhlafi, Hesham M, Alonso, Jordi, Al-Raddadi, Rajaa M, Altirkawi, Khalid A, Alumran, Arwa Khalid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Ameyaw, Edward Kwabena, Amini, Saeed, Amini-Rarani, Mostafa, Amit, Arianna Maever L, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Andrei, Catalina Liliana, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Aqeel, Muhammad, Arabloo, Jalal, Arab-Zozani, Morteza, Aripov, Timur, Ärnlöv, Johan, Artanti, Kurnia Dwi, Arzani, Afsaneh, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A, Asghari Jafarabadi, Mohammad, Athari, Seyyed Shamsadin, Athari, Seyyede Masoume, Atnafu, Desta Debalkie, Atreya, Alok, Atteraya, Madhu Sudhan, Ausloos, Marcel, Awan, Asma Tahir, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, B, Darshan B, Babaee, Ebrahim, Badiye, Ashish D, Baig, Atif Amin, Banach, Maciej, Banik, Palash Chandra, Barker-Collo, Suzanne Lyn, Barqawi, Hiba Jawdat, Bassat, Quique, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Bedi, Neeraj, Beghi, Ettore, Beghi, Massimiliano, Bell, Michelle L, Bendak, Salaheddine, Bennett, Derrick A, Bensenor, Isabela M, Berhe, Kidanemaryam, Berman, Adam E, Bezabih, Yihienew Mequanint, Bhagavathula, Akshaya Srikanth, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bhattarai, Suraj, Bhutta, Zulfiqar A, Bikbov, Boris, Biondi, Antonio, Birihane, Binyam Minuye, Biswas, Raaj Kishore, Bohlouli, Somayeh, Bragazzi, Nicola Luigi, Breusov, Alexey V, Brunoni, Andre R, Burkart, Katrin, Burugina Nagaraja, Sharath, Busse, Reinhard, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cahuana-Hurtado, Lucero, Camargos, Paulo, Cámera, Luis Alberto, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Cerin, Ester, Chang, Jung-Chen, Chanie, Wagaye Fentahun, Charan, Jaykaran, Chatterjee, Souranshu, Chattu, Soosanna Kumary, Chattu, Vijay Kumar, Chaturvedi, Sarika, Chen, Simiao, Cho, Daniel Youngwhan, Choi, Jee-Young Jasmine, Chu, Dinh-Toi, Ciobanu, Liliana G, Cirillo, Massimo, Conde, Joao, Costa, Vera Marisa, Couto, Rosa A S, Dachew, Berihun Assefa, Dahlawi, Saad M A, Dai, Hancheng, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Darmstadt, Gary L, Das, Jai K, Dávila-Cervantes, Claudio Alberto, Davis, Adrian C, Davletov, Kairat, De la Hoz, Fernando Pio, De Leo, Diego, Deeba, Farah, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Desalew, Assefa, Deuba, Keshab, Dey, Sagnik, Dharmaratne, Samath Dhamminda, Dhingra, Sameer, Dhungana, Govinda Prasad, Dias da Silva, Diana, Diaz, Daniel, Dorostkar, Fariba, Doshmangir, Leila, Dubljanin, Eleonora, Duraes, Andre Rodrigues, Eagan, Arielle Wilder, Edinur, Hisham Atan, Efendi, Ferry, Eftekharzadeh, Sahar, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, Elgendy, Islam Y, El-Jaafary, Shaimaa I, Emami, Amir, Enany, Shymaa, Eyawo, Oghenowede, Ezzikouri, Sayeh, Faris, Pawan Sirwan, Farzadfar, Farshad, Fattahi, Nazir, Fauk, Nelsensius Klau, Fazlzadeh, Mehdi, Feigin, Valery L, Ferede, Tomas Y, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferrara, Pietro, Filip, Irina, Fischer, Florian, Fisher, James L, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Foroutan, Masoud, Franklin, Richard Charles, Freitas, Marisa, Friedman, Sara D, Fukumoto, Takeshi, Gad, Mohamed M, Gaidhane, Abhay Motiramji, Gaidhane, Shilpa, Gaihre, Santosh, Gallus, Silvano, Garcia-Basteiro, Alberto L, Garcia-Gordillo, MA, Gardner, William M, Gaspar Fonseca, Mariana, Gebremedhin, Ketema Bizuwork, Getacher, Lemma, Ghashghaee, Ahmad, Gholamian, Asadollah, Gilani, Syed Amir, Gill, Tiffany K, Giussani, Giorgia, Gnedovskaya, Elena V, Godinho, Myron Anthony, Goel, Amit, Golechha, Mahaveer, Gona, Philimon N, Gopalani, Sameer Vali, Goudarzi, Houman, Grivna, Michal, Gugnani, Harish Chander, Guido, Davide, Guimarães, Rafael Alves, Gupta, Rajat Das, Gupta, Rajeev, Hafezi-Nejad, Nima, Haider, Mohammad Rifat, Haj-Mirzaian, Arvin, Hamidi, Samer, Hanif, Asif, Hankey, Graeme J, Hargono, Arief, Hasaballah, Ahmed I, Hasan, Md Mehedi, Hasan, Syed Shahzad, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J, Hayat, Khezar, Heidari-Soureshjani, Reza, Henry, Nathaniel J, Herteliu, Claudiu, Hole, Michael K, Holla, Ramesh, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Huang, Junjie, Humayun, Ayesha, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Inamdar, Sumant, Inbaraj, Leeberk Raja, Iqbal, Khalid, Iqbal, Usman, Islam, M Mofizul, Islam, Sheikh Mohammed Shariful, Iso, Hiroyasu, Iwagami, Masao, Iwu, Chidozie C D, Jaafari, Jalil, Jacobsen, Kathryn H, Jagnoor, Jagnoor, Jain, Vardhmaan, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Javanmardi, Fatemeh, Jayaram, Shubha, Jayatilleke, Achala Upendra, Jenabi, Ensiyeh, Jha, Ravi Prakash, Ji, John S, John, Oommen, Jonas, Jost B, Joo, Tamas, Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalankesh, Leila R, Kamyari, Naser, Kanchan, Tanuj, Kapoor, Neeti, Karami Matin, Behzad, Karch, André, Karimi, Salah Eddin, Kassahun, Getinet, Kayode, Gbenga A, Kazemi Karyani, Ali, Kemmer, Laura, Khalid, Nauman, Khalilov, Rovshan, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Maseer, Khan, Md Nuruzzaman, Khang, Young-Ho, Khatab, Khaled, Khater, Amir M, Khater, Mona M, Khayamzadeh, Maryam, Khosravi, Ardeshir, Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kissoon, Niranjan, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kulkarni, Vaman, Kumar, G Anil, Kumar, Manasi, Kumar, Nithin, Kurmi, Om P, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lalloo, Ratilal, Lami, Faris Hasan, Landires, Iván, Larsson, Anders O, Lasrado, Savita, Lassi, Zohra S, Lauriola, Paolo, Lee, Paul H, Lee, Shaun Wen Huey, Lee, Yo Han, Leigh, James, Leonardi, Matilde, Lewycka, Sonia, Li, Bingyu, Li, Shanshan, Liang, Juan, Lim, Lee-Ling, Limenih, Miteku Andualem, Lin, Ro-Ting, Liu, Xuefeng, Lodha, Rakesh, Lopez, Alan D, Lozano, Rafael, Lugo, Alessandra, Lunevicius, Raimundas, Mackay, Mark T, Madhava Kunjathur, Shilpashree, Magnani, Francesca Giulia, Mahadeshwara Prasad, D R, Maheri, Mina, Mahmoudi, Morteza, Majeed, Azeem, Maled, Venkatesh, Maleki, Afshin, Maleki, Shokofeh, Malekzadeh, Reza, Malik, Ahmad Azam, Malta, Deborah Carvalho, Mamun, Abdullah A, Mansouri, Borhan, Mansournia, Mohammad Ali, Martinez, Gabriel, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masoumi, Seyedeh Zahra, Maulik, Pallab K, McAlinden, Colm, McGrath, John J, Medina-Solís, Carlo Eduardo, Mehrabi Nasab, Entezar, Mejia-Rodriguez, Fabiola, Memish, Ziad A, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mersha, Abera M, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R, Mini, GK, Miri, Mohammad, Mirica, Andreea, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Moazen, Babak, Moghadaszadeh, Masoud, Mohajer, Bahram, Mohamad, Osama, Mohammad, Yousef, Mohammadi, Seyyede Momeneh, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Mondello, Stefania, Moni, Mohammad Ali, Moore, Catrin E, Moradi, Ghobad, Moradi, Masoud, Moradzadeh, Rahmatollah, Moraga, Paula, Morawska, Lidia, Morrison, Shane Douglas, Mosser, Jonathan F, Mousavi Khaneghah, Amin, Mustafa, Ghulam, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Nagaraju, Shankar Prasad, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naimzada, Mukhammad David, Nangia, Vinay, Narasimha Swamy, Sreenivas, Nascimento, Bruno Ramos, Naveed, Muhammad, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ionut, Negoi, Ruxandra Irina, Nena, Evangelia, Nepal, Samata, Netsere, Henok Biresaw, Nguefack-Tsague, Georges, Ngunjiri, Josephine W, Nguyen, Chi Thi Yen, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nigatu, Yeshambel T, Nigussie, Samuel Negash, Nixon, Molly R, Nnaji, Chukwudi A, Nomura, Shuhei, Noor, Nurulamin M, Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Nwatah, Vincent Ebuka, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Ogbo, Felix Akpojene, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omar Bali, Ahmed, Onwujekwe, Obinna E, Ortiz, Alberto, Otoiu, Adrian, Otstavnov, Nikita, Otstavnov, Stanislav S, Owolabi, Mayowa O, P A, Mahesh, Padubidri, Jagadish Rao, Pakhale, Smita, Pakshir, Keyvan, Pal, Pramod Kumar, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Pandey, Anamika, Pandey, Ashok, Pandi-Perumal, Seithikurippu R, Pangaribuan, Helena Ullyartha, Pardo-Montaño, Ana Melisa, Park, Eun-Kee, Patel, Sangram Kishor, Patton, George C, Pawar, Shrikant, Pazoki Toroudi, Hamidreza, Peden, Amy E, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K, Pereira, Jeevan, Pérez-Gómez, Jorge, Perico, Norberto, Pesudovs, Konrad, Pilgrim, Thomas, Pinheiro, Marina, Piradov, Michael A, Pirsaheb, Meghdad, Platts-Mills, James A, Pokhrel, Khem Narayan, Postma, Maarten J, Pourjafar, Hadi, Prada, Sergio I, Prakash, Sanjay, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Rabiee, Navid, Radfar, Amir, Rafiee, Ata, Rafiei, Alireza, Raggi, Alberto, Rahimzadeh, Shadi, Rahman, Mohammad Hifz Ur, Rahmani, Amir Masoud, Ramezanzadeh, Kiana, Rana, Juwel, Ranabhat, Chhabi Lal, Rao, Sowmya J, Rasella, Davide, Rastogi, Prateek, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rawasia, Wasiq Faraz, Rawassizadeh, Reza, Reiner Jr, Robert C, Remuzzi, Giuseppe, Renzaho, Andre M N, Reshmi, Bhageerathy, Resnikoff, Serge, Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Riahi, Seyed Mohammad, Ribeiro, Daniela, Rickard, Jennifer, Roever, Leonardo, Ronfani, Luca, Rothenbacher, Dietrich, Rubagotti, Enrico, Rumisha, Susan Fred, Ryan, Paul MacDaragh, Saddik, Basema, Sadeghi, Ehsan, Saeedi Moghaddam, Sahar, Sagar, Rajesh, Sahebkar, Amirhossein, Salahshoor, Mohammad Reza, Salehi, Sana, Salem, Marwa Rashad, Salimzadeh, Hamideh, Salomon, Joshua A, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sarker, Abdur Razzaque, Sarrafzadegan, Nizal, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saxena, Sonia, Saya, Ganesh Kumar, Saylan, Mete, Schiavolin, Silvia, Schlaich, Markus P, Schwebel, David C, Schwendicke, Falk, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serván-Mori, Edson, Sha, Feng, Shafaat, Omid, Shahabi, Saeed, Shahbaz, Mohammad, Shaheen, Amira A, Shahid, Izza, Shaikh, Masood Ali, Shakiba, Saeed, Shalash, Ali S, Shams-Beyranvand, Mehran, Shannawaz, Mohammed, Sharafi, Kiomars, Sheikh, Aziz, Sheikhbahaei, Sara, Shiferaw, Wondimeneh Shibabaw, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Shiue, Ivy, Shuval, Kerem, Siddiqi, Tariq Jamal, Sidemo, Negussie Boti, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, João Pedro, Silverberg, Jonathan I S, Simonetti, Biagio, Singh, Balbir Bagicha, Singh, Jasvinder A, Singhal, Deepika, Sinha, Dhirendra Narain, Skiadaresi, Eirini, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Sobaih, Badr Hasan, Sobhiyeh, Mohammad Reza, Soltani, Shahin, Soriano, Joan B, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Steiropoulos, Paschalis, Stokes, Mark A, Stortecky, Stefan, Sufiyan, Mu'awiyyah Babale, Suliankatchi Abdulkader, Rizwan, Sulo, Gerhard, Swope, Carolyn B, Sykes, Bryan L, Szeto, Mindy D, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tadesse, Eyayou Girma, Taherkhani, Amir, Tamiru, Animut Tagele, Tareque, Md Ismail, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Tesfay, Fisaha Haile, Tessema, Gizachew Assefa, Tessema, Zemenu Tadesse, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Tolani, Musliu Adetola, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Bach Xuan, Tripathy, Jaya Prasad, Tsapparellas, Giorgos, Tsatsakis, Aristidis, Tudor Car, Lorainne, Uddin, Riaz, Ullah, Anayat, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Usman, Muhammad Shariq, Vacante, Marco, Vaezi, Maryam, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Verma, Madhur, Violante, Francesco S, Vlassov, Vasily, Vo, Bay, Vu, Giang Thu, Wado, Yohannes Dibaba, Waheed, Yasir, Wamai, Richard G, Wang, Yanping, Wang, Yanzhong, Wang, Yuan-Pang, Ward, Paul, Werdecker, Andrea, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Wilner, Lauren B, Wiysonge, Charles Shey, Wu, Ai-Min, Wu, Chenkai, Xie, Yang, Yahyazadeh Jabbari, Seyed Hossein, Yamagishi, Kazumasa, Yandrapalli, Srikanth, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yu, Chuanhua, Yusuf, Sifat Shahana, Zaidi, Syed Saoud, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Xiu-Ju George, Ziapour, Arash, Hay, Simon I, Murray, Christopher J L, Wang, Haidong, and Kassebaum, Nicholas J

Published
2021
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27. Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk

Author

Fox, Christine K, Mackay, Mark T, Dowling, Michael M, Pergami, Paola, Titomanlio, Luigi, Deveber, Gabrielle, and Investigators, the SIPS

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Brain Disorders, Pediatric, Neurodegenerative, Clinical Research, Stroke, Epilepsy, Management of diseases and conditions, 7.3 Management and decision making, Adolescent, Age Factors, Brain Ischemia, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Online Systems, Recurrence, Risk Factors, SIPS Investigators, Medical and Health Sciences, Pediatrics, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

AimTo determine epilepsy risk factors after pediatric stroke.MethodA cohort of children with arterial ischemic stroke (birth-18y) was enrolled at 21 centers and followed for 1 year. Acute seizures (≤7d after stroke) and active epilepsy (at least one unprovoked remote seizure plus maintenance anticonvulsant at 1y) were identified. Predictors were determined using logistic regression.ResultsAmong 114 patients (28 neonates and 86 children) enrolled, 26 neonates (93%) and 32 children (37%) had an acute seizure. Acute seizures lasted longer than 5 minutes in 23 patients (40%) and were frequently recurrent: 33 (57%) had 2 to 10 seizures and 11 (19%) had more than 10. Among 109 patients with 1-year follow-up, 11 (10%) had active epilepsy. For each year younger, active epilepsy was 20% more likely (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.6-0.99, p=0.041). Prolonged or recurrent acute seizures also increased epilepsy risk. Each additional 10 minutes of the longest acute seizure increased epilepsy risk fivefold (OR 4.7, 95% CI 1.7-13). Patients with more than 10 acute seizures had a 30-fold increased epilepsy risk (OR 30, 95% CI 2.9-305).InterpretationPediatric stroke survivors, especially younger children, have a high risk of epilepsy 1 year after stroke. Prolonged or recurrent acute seizures increase epilepsy risk in a dose-dependent manner.

Published
2017

28. NEXMIF encephalopathy: an X-linked disorder with male and female phenotypic patterns

Author

Stamberger, Hannah, Hammer, Trine B., Gardella, Elena, Vlaskamp, Danique R. M., Bertelsen, Birgitte, Mandelstam, Simone, de Lange, Iris, Zhang, Jing, Myers, Candace T., Fenger, Christina, Afawi, Zaid, Almanza Fuerte, Edith P., Andrade, Danielle M., Balcik, Yunus, Ben Zeev, Bruria, Bennett, Mark F., Berkovic, Samuel F., Isidor, Bertrand, Bouman, Arjan, Brilstra, Eva, Busk, Øyvind L., Cairns, Anita, Caumes, Roseline, Chatron, Nicolas, Dale, Russell C., de Geus, Christa, Edery, Patrick, Gill, Deepak, Granild-Jensen, Jacob Bie, Gunderson, Lauren, Gunning, Boudewijn, Heimer, Gali, Helle, Johan R., Hildebrand, Michael S., Hollingsworth, Georgie, Kharytonov, Volodymyr, Klee, Eric W., Koeleman, Bobby P. C., Koolen, David A., Korff, Christian, Küry, Sébastien, Lesca, Gaetan, Lev, Dorit, Leventer, Richard J., Mackay, Mark T., Macke, Erica L., McEntagart, Meriel, Mohammad, Shekeeb S., Monin, Pauline, Montomoli, Martino, Morava, Eva, Moutton, Sebastien, Muir, Alison M., Parrini, Elena, Procopis, Peter, Ranza, Emmanuelle, Reed, Laura, Reif, Philipp S., Rosenow, Felix, Rossi, Massimiliano, Sadleir, Lynette G., Sadoway, Tara, Schelhaas, Helenius J., Schneider, Amy L., Shah, Krati, Shalev, Ruth, Sisodiya, Sanjay M., Smol, Thomas, Stumpel, Connie T. R. M., Stuurman, Kyra, Symonds, Joseph D., Mau-Them, Frederic Tran, Verbeek, Nienke, Verhoeven, Judith S., Wallace, Geoffrey, Yosovich, Keren, Zarate, Yuri A., Zerem, Ayelet, Zuberi, Sameer M., Guerrini, Renzo, Mefford, Heather C., Patel, Chirag, Zhang, Yue-Hua, Møller, Rikke S., and Scheffer, Ingrid E.

Published
2021
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33. Impact of stroke volume on motor outcome in neonatal arterial ischemic stroke

Author

Mori, Andrea Capone, Bigi, Sandra, Datta, Alexandre, Fluss, Joël, Hackenberg, Annette, Keller, Elmar, MacKay, Mark T., Maier, Olive, Mercati, Danielle, Marcoz, Jean-Pierre, Poloni, Claudia, Ramelli, Gian Paolo, Regényi, Maria, Schmid, Regula, Schmitt-Mechelke, Thomas, Wiedemann, Andreas, Pastore-Wapp, Manuela, Slavova, Nedelina, Steiner, Leonie, Weisstanner, Christian, Regényi, Mária, Steinlin, Maja, and Grunt, Sebastian

Published
2020
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34. Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence.

Author

Fullerton, Heather J, deVeber, Gabrielle A, Hills, Nancy K, Dowling, Michael M, Fox, Christine K, Mackay, Mark T, Kirton, Adam, Yager, Jerome Y, Bernard, Timothy J, Hod, Eldad A, Wintermark, Max, Elkind, Mitchell SV, and VIPS Investigators

Subjects
VIPS Investigators, Humans, Brain Ischemia, Cerebral Arterial Diseases, Recurrence, Peroxidase, Tumor Necrosis Factor-alpha, C-Reactive Protein, Serum Amyloid A Protein, Risk Factors, Adolescent, Child, Child, Preschool, Female, Male, Stroke, Biomarkers, C-reactive protein, Cox proportional hazards models, biomarkers, inflammation, serum amyloid A protein, stroke, Prevention, Pediatric, Brain Disorders, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

Background and purposeAmong children with arterial ischemic stroke (AIS), those with arteriopathy have the highest recurrence risk. We hypothesized that arteriopathy progression is an inflammatory process and that inflammatory biomarkers would predict recurrent AIS.MethodsIn an international study of childhood AIS, we selected cases classified into 1 of the 3 most common childhood AIS causes: definite arteriopathic (n=103), cardioembolic (n=55), or idiopathic (n=78). We measured serum concentrations of high-sensitivity C-reactive protein, serum amyloid A, myeloperoxidase, and tumor necrosis factor-α. We used linear regression to compare analyte concentrations across the subtypes and Cox proportional hazards models to determine predictors of recurrent AIS.ResultsMedian age at index stroke was 8.2 years (interquartile range, 3.6-14.3); serum samples were collected at median 5.5 days post stroke (interquartile range, 3-10 days). In adjusted models (including age, infarct volume, and time to sample collection) with idiopathic as the reference, the cardioembolic (but not arteriopathic) group had higher concentrations of high-sensitivity C-reactive protein and myeloperoxidase, whereas both cardioembolic and arteriopathic groups had higher serum amyloid A. In the arteriopathic (but not cardioembolic) group, higher high-sensitivity C-reactive protein and serum amyloid A predicted recurrent AIS. Children with progressive arteriopathies on follow-up imaging had higher recurrence rates, and a trend toward higher high-sensitivity C-reactive protein and serum amyloid A, compared with children with stable or improved arteriopathies.ConclusionsAmong children with AIS, specific inflammatory biomarkers correlate with cause and-in the arteriopathy group-risk of stroke recurrence. Interventions targeting inflammation should be considered for pediatric secondary stroke prevention trials.

Published
2016

35. Risk of Recurrent Arterial Ischemic Stroke in Childhood

Author

Fullerton, Heather J, Wintermark, Max, Hills, Nancy K, Dowling, Michael M, Tan, Marilyn, Rafay, Mubeen F, Elkind, Mitchell SV, Barkovich, A James, deVeber, Gabrielle A, Plumb, Patricia A, Benedict, Susan L, Bernard, Timothy J, Fox, Christine K, Friedman, Neil R, Lo, Warren D, Ichord, Rebecca N, Mackay, Mark T, Kirton, Adam, Hernandez-Chavez, Marta I, Humphreys, Peter, Jordan, Lori C, Sultan, Sally, Rivkin, Michael J, Titomanlio, Luigi, Kovacevic, Gordana S, Yager, Jerome Y, Amlie-Lefond, Catherine, Dlamini, Nomazulu, Condie, John, Yeh, Ann, Kneen, Rachel, Bjornson, Bruce, Pergami, Paola, Zou, Li Ping, Elbers, Jorina M, Abdalla, Abdalla, Chan, Anthony K, Farooq, Osman, Lim, Mingming J, Carpenter, Jessica L, Pavlakis, Steven, Wong, Virginia C, and Forsyth, Robert

Subjects
Paediatrics, Biomedical and Clinical Sciences, Brain Disorders, Pediatric, Stroke, Prevention, Neurosciences, Atherosclerosis, Adolescent, Brain Ischemia, Cerebral Arterial Diseases, Child, Child, Preschool, Cohort Studies, Female, Follow-Up Studies, Humans, Infant, Internationality, Male, Prospective Studies, Recurrence, Risk Factors, child, pediatrics, risk factor, stroke, vaccination, VIPS Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposePublished cohorts of children with arterial ischemic stroke (AIS) in the 1990s to early 2000s reported 5-year cumulative recurrence rates approaching 20%. Since then, utilization of antithrombotic agents for secondary stroke prevention in children has increased. We sought to determine rates and predictors of recurrent stroke in the current era.MethodsThe Vascular Effects of Infection in Pediatric Stroke (VIPS) study enrolled 355 children with AIS at 37 international centers from 2009 to 2014 and followed them prospectively for recurrent stroke. Index and recurrent strokes underwent central review and confirmation, as well as central classification of causes of stroke, including arteriopathies. Other predictors were measured via parental interview or chart review.ResultsOf the 355 children, 354 survived their acute index stroke, and 308 (87%) were treated with an antithrombotic medication. During a median follow-up of 2.0 years (interquartile range, 1.0-3.0), 40 children had a recurrent AIS, and none had a hemorrhagic stroke. The cumulative stroke recurrence rate was 6.8% (95% confidence interval, 4.6%-10%) at 1 month and 12% (8.5%-15%) at 1 year. The sole predictor of recurrence was the presence of an arteriopathy, which increased the risk of recurrence 5-fold when compared with an idiopathic AIS (hazard ratio, 5.0; 95% confidence interval, 1.8-14). The 1-year recurrence rate was 32% (95% confidence interval, 18%-51%) for moyamoya, 25% (12%-48%) for transient cerebral arteriopathy, and 19% (8.5%-40%) for arterial dissection.ConclusionsChildren with AIS, particularly those with arteriopathy, remain at high risk for recurrent AIS despite increased utilization of antithrombotic agents. Therapies directed at the arteriopathies themselves are needed.

Published
2016

37. OP85 Cost Effectiveness Of Prednisolone To Treat Bell’s Palsy In Children: An Economic Evaluation Alongside A Randomized Controlled Trial

Author

Xiong, Xiuqin, primary, Huang, Li, additional, Herd, David, additional, Borland, Meredith, additional, Davidson, Andrew, additional, Hearps, Stephen, additional, Mackay, Mark, additional, Lee, Katherine, additional, Dalziel, Stuart, additional, Dalziel, Kim, additional, Cheek, John, additional, and Babl, Franz, additional

Published
2023
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39. Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Children and Youth Aged 0-19 Years: Data from the Global and Regional Burden of Stroke 2013

Author

Krishnamurthi, Rita V, deVeber, Gabrielle, Feigin, Valery L, Barker-Collo, Suzanne, Fullerton, Heather, Mackay, Mark T, O'Callahan, Finbar, Lindsay, M Patrice, Kolk, Anneli, Lo, Warren, Shah, Priyanka, Linds, Alexandra, Jones, Kelly, Parmar, Priya, Taylor, Steve, Norrving, Bo, Mensah, George A, Moran, Andrew E, Naghavi, Mohsen, Forouzanfar, Mohammed H, Nguyen, Grant, Johnson, Catherine O, Vos, Theo, Murray, Christopher JL, and Roth, Gregory A

Subjects
Prevention, Brain Disorders, Neurosciences, Stroke, Emerging Infectious Diseases, Aetiology, 2.4 Surveillance and distribution, Good Health and Well Being, Adolescent, Adult, Child, Child, Preschool, Cost of Illness, Disabled Persons, Female, Global Health, Health Surveys, Humans, Incidence, Infant, Male, Prevalence, Quality-Adjusted Life Years, Young Adult, Childhood stroke, Stroke epidemiology, Deaths, Disability-adjusted life years, GBD 2013 Stroke Panel Experts Group, Public Health and Health Services, Epidemiology
Abstract

BackgroundThere is increasing recognition of stroke as an important contributor to childhood morbidity and mortality. Current estimates of global childhood stroke burden and its temporal trends are sparse. Accurate and up-to-date estimates of childhood stroke burden are important for planning research and the resulting evidence-based strategies for stroke prevention and management.ObjectivesTo estimate the prevalence, mortality and disability-adjusted life years (DALYs) for ischemic stroke (IS), hemorrhagic stroke (HS) and all stroke types combined globally from 1990 to 2013.MethodologyStroke prevalence, mortality and DALYs were estimated using the Global Burden of Disease 2013 methods. All available data on stroke-related incidence, prevalence, excess mortality and deaths were collected. Statistical models and country-level covariates were employed to produce comprehensive and consistent estimates of prevalence and mortality. Stroke-specific disability weights were used to estimate years lived with disability and DALYs. Means and 95% uncertainty intervals (UIs) were calculated for prevalence, mortality and DALYs. The median of the percent change and 95% UI were determined for the period from 1990 to 2013.ResultsIn 2013, there were 97,792 (95% UI 90,564-106,016) prevalent cases of childhood IS and 67,621 (95% UI 62,899-72,214) prevalent cases of childhood HS, reflecting an increase of approximately 35% in the absolute numbers of prevalent childhood strokes since 1990. There were 33,069 (95% UI 28,627-38,998) deaths and 2,615,118 (95% UI 2,265,801-3,090,822) DALYs due to childhood stroke in 2013 globally, reflecting an approximately 200% decrease in the absolute numbers of death and DALYs in childhood stroke since 1990. Between 1990 and 2013, there were significant increases in the global prevalence rates of childhood IS, as well as significant decreases in the global death rate and DALYs rate of all strokes in those of age 0-19 years. While prevalence rates for childhood IS and HS decreased significantly in developed countries, a decline was seen only in HS, with no change in prevalence rates of IS, in developing countries. The childhood stroke DALY rates in 2013 were 13.3 (95% UI 10.6-17.1) for IS and 92.7 (95% UI 80.5-109.7) for HS per 100,000. While the prevalence of childhood IS compared to childhood HS was similar globally, the death rate and DALY rate of HS was 6- to 7-fold higher than that of IS. In 2013, the prevalence rate of both childhood IS and HS was significantly higher in developed countries than in developing countries. Conversely, both death and DALY rates for all stroke types were significantly lower in developed countries than in developing countries in 2013. Men showed a trend toward higher childhood stroke death rates (1.5 (1.3-1.8) per 100,000) than women (1.1 (0.9-1.5) per 100,000) and higher childhood stroke DALY rates (120.1 (100.8-143.4) per 100,000) than women (90.9 (74.6-122.4) per 100,000) globally in 2013.ConclusionsGlobally, between 1990 and 2013, there was a significant increase in the absolute number of prevalent childhood strokes, while absolute numbers and rates of both deaths and DALYs declined significantly. The gap in childhood stroke burden between developed and developing countries is closing; however, in 2013, childhood stroke burden in terms of absolute numbers of prevalent strokes, deaths and DALYs remained much higher in developing countries. There is an urgent need to address these disparities with both global and country-level initiatives targeting prevention as well as improved access to acute and chronic stroke care.

Published
2015

40. Stroke in Children With Cardiac Disease: Report From the International Pediatric Stroke Study Group Symposium

Author

Sinclair, Adriane J, Fox, Christine K, Ichord, Rebecca N, Almond, Christopher S, Bernard, Timothy J, Beslow, Lauren A, Chan, Anthony KC, Cheung, Michael, deVeber, Gabrielle, Dowling, Michael M, Friedman, Neil, Giglia, Therese M, Guilliams, Kristin P, Humpl, Tilman, Licht, Daniel J, Mackay, Mark T, and Jordan, Lori C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Cardiovascular, Clinical Research, Neurosciences, Brain Disorders, Stroke, Pediatric, Good Health and Well Being, Child, Heart Diseases, Humans, cardiac, stroke, arterial ischemic, congenital heart disease, Paediatrics and Reproductive Medicine, Neurology & Neurosurgery, Paediatrics
Abstract

BackgroundCardiac disease is a leading cause of stroke in children, yet limited data support the current stroke prevention and treatment recommendations. A multidisciplinary panel of clinicians was convened in February 2014 by the International Pediatric Stroke Study group to identify knowledge gaps and prioritize clinical research efforts for children with cardiac disease and stroke.ResultsSignificant knowledge gaps exist, including a lack of data on stroke incidence, predictors, primary and secondary stroke prevention, hyperacute treatment, and outcome in children with cardiac disease. Commonly used diagnostic techniques including brain computed tomography and ultrasound have low rates of stroke detection, and diagnosis is frequently delayed. The challenges of research studies in this population include epidemiologic barriers to research such as small patient numbers, heterogeneity of cardiac disease, and coexistence of multiple risk factors. Based on stroke burden and study feasibility, studies involving mechanical circulatory support, single ventricle patients, early stroke detection strategies, and understanding secondary stroke risk factors and prevention are the highest research priorities over the next 5-10 years. The development of large-scale multicenter and multispecialty collaborative research is a critical next step. The designation of centers of expertise will assist in clinical care and research.ConclusionsThere is an urgent need for additional research to improve the quality of evidence in guideline recommendations for cardiogenic stroke in children. Although significant barriers to clinical research exist, multicenter and multispecialty collaboration is an important step toward advancing clinical care and research for children with cardiac disease and stroke.

Published
2015

42. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Feigin, Valery L, Nichols, Emma, Alam, Tahiya, Bannick, Marlena S, Beghi, Ettore, Blake, Natacha, Culpepper, William J, Dorsey, E Ray, Elbaz, Alexis, Ellenbogen, Richard G, Fisher, James L, Fitzmaurice, Christina, Giussani, Giorgia, Glennie, Linda, James, Spencer L, Johnson, Catherine Owens, Kassebaum, Nicholas J, Logroscino, Giancarlo, Marin, Benoît, Mountjoy-Venning, W Cliff, Nguyen, Minh, Ofori-Asenso, Richard, Patel, Anoop P, Piccininni, Marco, Roth, Gregory A, Steiner, Timothy J, Stovner, Lars Jacob, Szoeke, Cassandra E I, Theadom, Alice, Vollset, Stein Emil, Wallin, Mitchell Taylor, Wright, Claire, Zunt, Joseph Raymond, Abbasi, Nooshin, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Aboyans, Victor, Abraha, Haftom Niguse, Acharya, Dilaram, Adamu, Abdu A, Adebayo, Oladimeji M, Adeoye, Abiodun Moshood, Adsuar, Jose C, Afarideh, Mohsen, Agrawal, Sutapa, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Eyadhy, Ayman, Al-Shahi Salman, Rustam, Alahdab, Fares, Alene, Kefyalew Addis, Aljunid, Syed Mohamed, Altirkawi, Khalid, Alvis-Guzman, Nelson, Anber, Nahla Hamed, Antonio, Carl Abelardo T, Arabloo, Jalal, Aremu, Olatunde, Ärnlöv, Johan, Asayesh, Hamid, Asghar, Rana Jawad, Atalay, Hagos Tasew, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayuk, Tambe B, Badawi, Alaa, Banach, Maciej, Banoub, Joseph Adel Mattar, Barboza, Miguel A, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Baune, Bernhard T, Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Béjot, Yannick, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Bennett, Derrick A, Bensenor, Isabela M, Berhane, Adugnaw, Beuran, Mircea, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Biadgo, Belete, Bijani, Ali, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Blazes, Christopher Kynrint, Brayne, Carol, Butt, Zahid A, Campos-Nonato, Ismael R, Cantu-Brito, Carlos, Car, Mate, Cárdenas, Rosario, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castro, Franz, Catalá-López, Ferrán, Cerin, Ester, Chaiah, Yazan, Chang, Jung-Chen, Chatziralli, Irini, Chiang, Peggy Pei-Chia, Christensen, Hanne, Christopher, Devasahayam J, Cooper, Cyrus, Cortesi, Paolo Angelo, Costa, Vera M, Criqui, Michael H, Crowe, Christopher Stephen, Damasceno, Albertino Antonio Moura, Daryani, Ahmad, De la Cruz-Góngora, Vanessa, De la Hoz, Fernando Pio, De Leo, Diego, Demoz, Gebre Teklemariam, Deribe, Kebede, Dharmaratne, Samath Dhamminda, Diaz, Daniel, Dinberu, Mesfin Tadese, Djalalinia, Shirin, Doku, David Teye, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Edvardsson, David, El-Khatib, Ziad, Endres, Matthias, Endries, Aman Yesuf, Eskandarieh, Sharareh, Esteghamati, Alireza, Esteghamati, Sadaf, Farhadi, Farzaneh, Faro, Andre, Farzadfar, Farshad, Farzaei, Mohammad Hosein, Fatima, Batool, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fukumoto, Takeshi, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Garcia-Gordillo, Miguel A, Gebre, Abadi Kahsu, Gebremichael, Teklu Gebrehiwo, Gelaw, Belayneh K, Geleijnse, Johanna M, Geremew, Demeke, Gezae, Kebede Embaye, Ghasemi-Kasman, Maryam, Gidey, Mahari Y, Gill, Paramjit Singh, Gill, Tiffany K, Girma, Efrata Tufa, Gnedovskaya, Elena V, Goulart, Alessandra C, Grada, Ayman, Grosso, Giuseppe, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Haagsma, Juanita A, Hagos, Tekleberhan B, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randah R, Hamidi, Samer, Hankey, Graeme J, Hao, Yuantao, Haro, Josep Maria, Hassankhani, Hadi, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Simon I, Hegazy, Mohamed I, Heidari, Behnam, Henok, Andualem, Heydarpour, Fatemeh, Hoang, Chi Linh, Hole, Michael K, Homaie Rad, Enayatollah, Hosseini, Seyed Mostafa, Hu, Guoqing, Igumbor, Ehimario U, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jakovljevic, Mihajlo, Javanbakht, Mehdi, Jha, Ravi Prakash, Jobanputra, Yash B, Jonas, Jost B, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kahsay, Amaha, Kalani, Rizwan, Kalkonde, Yogeshwar, Kamil, Teshome Abegaz, Kanchan, Tanuj, Karami, Manoochehr, Karch, André, Karimi, Narges, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kassa, Zemenu Yohannes, Kaul, Anil, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khang, Young-Ho, Khazaie, Habibolah, Kiadaliri, Aliasghar A, Kiirithio, Daniel N, Kim, Anthony S, Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kisa, Adnan, Kokubo, Yoshihiro, Koyanagi, Ai, Krishnamurthi, Rita V, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kumar, Manasi, Lacey, Ben, Lafranconi, Alessandra, Lansingh, Van C, Latifi, Arman, Leshargie, Cheru Tesema, Li, Shanshan, Liao, Yu, Linn, Shai, Lo, Warren David, Lopez, Jaifred Christian F, Lorkowski, Stefan, Lotufo, Paulo A, Lucas, Robyn M, Lunevicius, Raimundas, Mackay, Mark T, Mahotra, Narayan Bahadur, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manafi, Navid, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, März, Winfried, Mashamba-Thompson, Tivani Phosa, Massenburg, Benjamin Ballard, Mate, Kedar K V, McAlinden, Colm, McGrath, John J, Mehta, Varshil, Meier, Toni, Meles, Hagazi Gebre, Melese, Addisu, Memiah, Peter T N, Memish, Ziad A, Mendoza, Walter, Mengistu, Desalegn Tadese, Mengistu, Getnet, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Mini, GK, Mirrakhimov, Erkin M, Moazen, Babak, Mohajer, Bahram, Mohammad Gholi Mezerji, Naser, Mohammadi, Moslem, Mohammadi-Khanaposhtani, Maryam, Mohammadibakhsh, Roghayeh, Mohammadnia-Afrouzi, Mousa, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Mondello, Stefania, Moodley, Yoshan, Moosazadeh, Mahmood, Moradi, Ghobad, Moradi-Lakeh, Maziar, Moradinazar, Mehdi, Moraga, Paula, Moreno Velásquez, Ilais, Morrison, Shane Douglas, Mousavi, Seyyed Meysam, Muhammed, Oumer Sada, Muruet, Walter, Musa, Kamarul Imran, Mustafa, Ghulam, Naderi, Mehdi, Nagel, Gabriele, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Negoi, Ionut, Negoi, Ruxandra Irina, Newton, Charles Richard James, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Nguyen, Long Hoang, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nixon, Molly R, Norrving, Bo, Noubiap, Jean Jacques, Nourollahpour Shiadeh, Malihe, Nyasulu, Peter S, Ogah, Okechukwu Samuel, Oh, In-Hwan, Olagunju, Andrew T, Olagunju, Tinuke O, Olivares, Pedro R, Onwujekwe, Obinna E, Oren, Eyal, Owolabi, Mayowa Ojo, PA, Mahesh, Pakpour, Amir H, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Pandian, Jeyaraj Durai, Patel, Sangram Kishor, Pereira, David M, Petzold, Max, Pillay, Julian David, Piradov, Michael A, Polanczyk, Guilherme V, Polinder, Suzanne, Postma, Maarten J, Poulton, Richie, Poustchi, Hossein, Prakash, Swayam, Prakash, V, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rajati, Fatemeh, Ram, Usha, Ranta, Anna, Rawaf, David Laith, Rawaf, Salman, Reinig, Nickolas, Reis, Cesar, Renzaho, Andre M N, Resnikoff, Serge, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Rios González, Carlos Miguel, Roberts, Nicholas L S, Roever, Leonardo, Ronfani, Luca, Roro, Elias Merdassa, Roshandel, Gholamreza, Rostami, Ali, Sabbagh, Parisa, Sacco, Ralph L, Sachdev, Perminder S, Saddik, Basema, Safari, Hosein, Safari-Faramani, Roya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salamati, Payman, Salehi Zahabi, Saleh, Salimi, Yahya, Samy, Abdallah M, Sanabria, Juan, Santos, Itamar S, Santric Milicevic, Milena M, Sarrafzadegan, Nizal, Sartorius, Benn, Sarvi, Shahabeddin, Sathian, Brijesh, Satpathy, Maheswar, Sawant, Arundhati R, Sawhney, Monika, Schneider, Ione J C, Schöttker, Ben, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Shabaninejad, Hosein, Shafieesabet, Azadeh, Shaikh, Masood Ali, Shakir, Raad A, Shams-Beyranvand, Mehran, Shamsizadeh, Morteza, Sharif, Mehdi, Sharif-Alhoseini, Mahdi, She, Jun, Sheikh, Aziz, Sheth, Kevin N, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Siabani, Soraya, Siddiqi, Tariq J, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silberberg, Donald H, Silva, João Pedro, Silveira, Dayane Gabriele Alves, Singh, Jasvinder A, Sinha, Dhirendra Narain, Skiadaresi, Eirini, Smith, Mari, Sobaih, Badr Hasan, Sobhani, Soheila, Soofi, Moslem, Soyiri, Ireneous N, Sposato, Luciano A, Stein, Dan J, Stein, Murray B, Stokes, Mark A, Sufiyan, Mu'awiyyah Babale, Sykes, Bryan L, Sylaja, PN, Tabarés-Seisdedos, Rafael, Te Ao, Braden James, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Temsah, Omar, Thakur, Jarnail Singh, Thrift, Amanda G, Topor-Madry, Roman, Tortajada-Girbés, Miguel, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tran, Khanh Bao, Truelsen, Thomas Clement, Tsadik, Afewerki Gebremeskel, Tudor Car, Lorainne, Ukwaja, Kingsley Nnanna, Ullah, Irfan, Usman, Muhammad Shariq, Uthman, Olalekan A, Valdez, Pascual R, Vasankari, Tommi Juhani, Vasanthan, Rajagopalan, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasily, Vosoughi, Kia, Vu, Giang Thu, Vujcic, Isidora S, Wagnew, Fasil Shiferaw, Waheed, Yasir, Wang, Yuan-Pang, Weiderpass, Elisabete, Weiss, Jordan, Whiteford, Harvey A, Wijeratne, Tissa, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Wolfe, Charles D A, Xu, Gelin, Yadollahpour, Ali, Yamada, Tomohide, Yano, Yuichiro, Yaseri, Mehdi, Yatsuya, Hiroshi, Yimer, Ebrahim M, Yip, Paul, Yisma, Engida, Yonemoto, Naohiro, Yousefifard, Mahmoud, Yu, Chuanhua, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zandian, Hamed, Zare, Zohreh, Zhang, Yunquan, Zodpey, Sanjay, Naghavi, Mohsen, Murray, Christopher J L, and Vos, Theo

Published
2019
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43. Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Johnson, Catherine Owens, Nguyen, Minh, Roth, Gregory A, Nichols, Emma, Alam, Tahiya, Abate, Degu, Abd-Allah, Foad, Abdelalim, Ahmed, Abraha, Haftom Niguse, Abu-Rmeileh, Niveen ME, Adebayo, Oladimeji M, Adeoye, Abiodun Moshood, Agarwal, Gina, Agrawal, Sutapa, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Alahdab, Fares, Ali, Raghib, Alvis-Guzman, Nelson, Anber, Nahla Hamed, Anjomshoa, Mina, Arabloo, Jalal, Arauz, Antonio, Ärnlöv, Johan, Arora, Amit, Awasthi, Ashish, Banach, Maciej, Barboza, Miguel A, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Basu, Sanjay, Belachew, Abate Bekele, Belayneh, Yaschilal Muche, Bennett, Derrick A., Bensenor, Isabela M, Bhattacharyya, Krittika, Biadgo, Belete, Bijani, Ali, Bikbov, Boris, Bin Sayeed, Muhammad Shahdaat, Butt, Zahid A, Cahuana-Hurtado, Lucero, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castro, Franz, Catalá-López, Ferrán, Chaiah, Yazan, Chiang, Peggy Pei-Chia, Choi, Jee-Young J, Christensen, Hanne, Chu, Dinh-Toi, Cortinovis, Monica, Damasceno, Albertino Antonio Moura, Dandona, Lalit, Dandona, Rakhi, Daryani, Ahmad, Davletov, Kairat, de Courten, Barbora, De la Cruz-Góngora, Vanessa, Degefa, Meaza Girma, Dharmaratne, Samath Dhamminda, Diaz, Daniel, Dubey, Manisha, Duken, Eyasu Ejeta, Edessa, Dumessa, Endres, Matthias, FARAON, EMERITO JOSE A, Farzadfar, Farshad, Fernandes, Eduarda, Fischer, Florian, Flor, Luisa Sorio, Ganji, Morsaleh, Gebre, Abadi Kahsu, Gebremichael, Teklu Gebrehiwo, Geta, Birhanu, Gezae, Kebede Embaye, Gill, Paramjit Singh, Gnedovskaya, Elena V., Gómez-Dantés, Hector, Goulart, Alessandra C, Grosso, Giuseppe, Guo, Yuming, Gupta, Rajeev, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamidi, Samer, Hankey, Graeme J., Hassen, Hamid Yimam, Hay, Simon I., Hegazy, Mohamed I, Heidari, Behnam, Herial, Nabeel A, Hosseini, Mohammad Ali, Hostiuc, Sorin, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jahanmehr, Nader, Javanbakht, Mehdi, Jha, Ravi Prakash, Jonas, Jost B., Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kahsay, Amaha, Kalani, Rizwan, Kalkonde, Yogeshwar, Kamil, Teshome Abegaz, Kanchan, Tanuj, Karch, André, Karimi, Narges, Karimi-Sari, Hamidreza, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kazemeini, Hossein, Kefale, Adane Teshome, Khader, Yousef Saleh, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khang, Young-Ho, Khubchandani, Jagdish, Kim, Daniel, Kim, Yun Jin, Kisa, Adnan, Kivimäki, Mika, Koyanagi, Ai, Krishnamurthi, Rita K, Kumar, G Anil, Lafranconi, Alessandra, Lewington, Sarah, Li, Shanshan, Lo, Warren David, Lopez, Alan D, Lorkowski, Stefan, Lotufo, Paulo A., Mackay, Mark T, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Manafi, Navid, Mansournia, Mohammad Ali, Mehndiratta, Man Mohan, Mehta, Varshil, Mengistu, Getnet, Meretoja, Atte, Meretoja, Tuomo J, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Mirrakhimov, Erkin M, Mohajer, Bahram, Mohammad, Yousef, Mohammadoo-khorasani, Milad, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Mokhayeri, Yaser, Moradi, Ghobad, Morawska, Lidia, Moreno Velásquez, Ilais, Mousavi, Seyyed Meysam, Muhammed, Oumer Sada S, Muruet, Walter, Naderi, Mehdi, Naghavi, Mohsen, Naik, Gurudatta, Nascimento, Bruno Ramos, Negoi, Ruxandra Irina, Nguyen, Cuong Tat, Nguyen, Long Hoang, Nirayo, Yirga Legesse, Norrving, Bo, Noubiap, Jean Jacques, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Olagunju, Andrew T, Olagunju, Tinuke O, Owolabi, Mayowa Ojo, Pandian, Jeyaraj Durai, Patel, Shanti, Perico, Norberto, Piradov, Michael A, Polinder, Suzanne, Postma, Maarten J, Poustchi, Hossein, Prakash, V, Qorbani, Mostafa, Rafiei, Alireza, Rahim, Fakher, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Muhammad Aziz, Reis, Cesar, Remuzzi, Giuseppe, Renzaho, Andre M.N., Ricci, Stefano, Roberts, Nicholas L S, Robinson, Stephen R, Roever, Leonardo, Roshandel, Gholamreza, Sabbagh, Parisa, Safari, Hosein, Safari, Saeed, Safiri, Saeid, Sahebkar, Amirhossein, Salehi Zahabi, Saleh, Samy, Abdallah M., Santalucia, Paola, Santos, Itamar S, Santos, João Vasco, Santric Milicevic, Milena M, Sartorius, Benn, Sawant, Arundhati R, Schutte, Aletta Elisabeth, Sepanlou, Sadaf G., Shafieesabet, Azadeh, Shaikh, Masood Ali, Shams-Beyranvand, Mehran, Sheikh, Aziz, Sheth, Kevin N., Shibuya, Kenji, Shigematsu, Mika, Shin, Min-Jeong, Shiue, Ivy, Siabani, Soraya, Sobaih, Badr Hasan, Sposato, Luciano A., Sutradhar, Ipsita, Sylaja, PN, Szoeke, Cassandra E I, Te Ao, Braden James, Temsah, Mohamad-Hani, Temsah, Omar, Thrift, Amanda G, Tonelli, Marcello, Topor-Madry, Roman, Tran, Bach Xuan, Tran, Khanh Bao, Truelsen, Thomas Clement, Tsadik, Afewerki Gebremeskel, Ullah, Irfan, Uthman, Olalekan A, Vaduganathan, Muthiah, Valdez, Pascual R, Vasankari, Tommi Juhani, Vasanthan, Rajagopalan, Venketasubramanian, Narayanaswamy, Vosoughi, Kia, Vu, Giang Thu, Waheed, Yasir, Weiderpass, Elisabete, Weldegwergs, Kidu Gidey, Westerman, Ronny, Wolfe, Charles D A, Wondafrash, Dawit Zewdu, Xu, Gelin, Yadollahpour, Ali, Yamada, Tomohide, Yatsuya, Hiroshi, Yimer, Ebrahim M, Yonemoto, Naohiro, Yousefifard, Mahmoud, Yu, Chuanhua, Zaidi, Zoubida, Zamani, Mohammad, Zarghi, Afshin, Zhang, Yunquan, Zodpey, Sanjay, Feigin, Valery L., Vos, Theo, and Murray, Christopher J L

Published
2019
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44. Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Beghi, Ettore, Giussani, Giorgia, Nichols, Emma, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abraha, Haftom Niguse, Adib, Mina G., Agrawal, Sutapa, Alahdab, Fares, Awasthi, Ashish, Ayele, Yohanes, Barboza, Miguel A, Belachew, Abate Bekele, Biadgo, Belete, Bijani, Ali, Bitew, Helen, Carvalho, Félix, Chaiah, Yazan, Daryani, Ahmad, Do, Huyen Phuc, Dubey, Manisha, Endries, Aman Yesuf Yesuf, Eskandarieh, Sharareh, Faro, Andre, Farzadfar, Farshad, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fijabi, Daniel Obadare, Filip, Irina, Fischer, Florian, Gebre, Abadi Kahsu, Tsadik, Afewerki Gebremeskel, Gebremichael, Teklu Gebrehiwo, Gezae, Kebede Embaye, Ghasemi-Kasman, Maryam, Weldegwergs, Kidu Gidey, Degefa, Meaza Girma, Gnedovskaya, Elena V., Hagos, Tekleberhan B, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hassen, Hamid Yimam, Hay, Simon I, Jakovljevic, Mihajlo, Kasaeian, Amir, Kassa, Tesfaye Dessale, Khader, Yousef Saleh, Khalil, Ibrahim, Khan, Ejaz Ahmad, Khubchandani, Jagdish, Kisa, Adnan, Krohn, Kristopher J, Kulkarni, Chanda, Nirayo, Yirga Legesse, Mackay, Mark T, Majdan, Marek, Majeed, Azeem, Manhertz, Treh, Mehndiratta, Man Mohan, Mekonen, Tesfa, Meles, Hagazi Gebre, Mengistu, Getnet, Mohammed, Shafiu, Naghavi, Mohsen, Mokdad, Ali H, Mustafa, Ghulam, Irvani, Seyed Sina Naghibi, Nguyen, Long Hoang, Nixon, Molly R, Ogbo, Felix Akpojene, Olagunju, Andrew T, Olagunju, Tinuke O, Owolabi, Mayowa Ojo, Phillips, Michael R, Pinilla-Monsalve, Gabriel David, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Reinig, Nickolas, Sachdev, Perminder S, Safari, Hosein, Safari, Saeed, Safiri, Saeid, Sahraian, Mohammad Ali, Samy, Abdallah M., Sarvi, Shahabeddin, Sawhney, Monika, Shaikh, Masood A, Sharif, Mehdi, Singh, Gagandeep, Smith, Mari, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Temsah, Mohamad-Hani, Temsah, Omar, Tortajada-Girbés, Miguel, Tran, Bach Xuan, Tsegay, Amanuel Amanuel Tesfay, Ullah, Irfan, Venketasubramanian, Narayanaswamy, Westerman, Ronny, Winkler, Andrea Sylvia, Yimer, Ebrahim M, Yonemoto, Naohiro, Feigin, Valery L., Vos, Theo, and Murray, Christopher J L

Published
2019
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46. Pain in children with Bell's palsy: secondary analysis of a randomised controlled trial.

Author

Babl, Franz E., Eapen, Nitaa, Herd, David, Borland, Meredith L., Kochar, Amit, Lawton, Ben, Hort, Jason, West, Adam, George, Shane, Davidson, Andrew, Cheek, John A., Oakley, Ed, Hopper, Sandy M., Berkowitz, Robert G., Wilson, Catherine L., Williams, Amanda, MacKay, Mark T., Lee, Katherine J., Hearps, Stephen, and Dalziel, Stuart R.

Subjects
BELL'S palsy, FACIAL paralysis, RANDOMIZED controlled trials, SECONDARY analysis, LATENT tuberculosis, JUVENILE idiopathic arthritis
Abstract

This article provides a secondary analysis of a clinical trial on children with Bell's palsy, focusing on the prevalence and severity of pain in these patients. The study found that pain is not common in children with Bell's palsy and is more likely to occur early in the disease and in severe cases. The intensity of pain, if present, is generally low throughout the course of the illness. It is important for clinicians to assess for pain at the initial presentation and reassure patients and parents that it is unlikely to persist. However, persistent or high levels of pain may warrant consideration of alternative diagnoses. It is worth noting that the study did not include children with vesicles or possible Ramsay Hunt syndrome, so the findings may not apply to those conditions. [Extracted from the article]

Published
2024
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