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16 results on '"Machicote, Andres"'

2. IL-22 promotes liver regeneration after portal vein ligation

Author

Zhang, Tao, Seeger, Philipp, Simsek, Yashin, Sabihi, Morsal, Lücke, Jöran, Zazara, Dimitra E., Shiri, Ahmad Mustafa, Kempski, Jan, Blankenburg, Tom, Zhao, Lilan, Belios, Ioannis, Machicote, Andres, Mercanoglu, Baris, Fard-Aghaie, Mohammad, Notz, Sara, Lykoudis, Panagis M., Kemper, Marius, Ghadban, Tarik, Mann, Oliver, Hackert, Thilo, Izbicki, Jakob R., Renné, Thomas, Huber, Samuel, Giannou, Anastasios D., and Li, Jun

Published
2024
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3. X‑ray-Based Techniques to Study the Nano–Bio Interface

Author

Sanchez-Cano, Carlos, Alvarez-Puebla, Ramon A, Abendroth, John M, Beck, Tobias, Blick, Robert, Cao, Yuan, Caruso, Frank, Chakraborty, Indranath, Chapman, Henry N, Chen, Chunying, Cohen, Bruce E, Conceição, Andre LC, Cormode, David P, Cui, Daxiang, Dawson, Kenneth A, Falkenberg, Gerald, Fan, Chunhai, Feliu, Neus, Gao, Mingyuan, Gargioni, Elisabetta, Glüer, Claus-C, Grüner, Florian, Hassan, Moustapha, Hu, Yong, Huang, Yalan, Huber, Samuel, Huse, Nils, Kang, Yanan, Khademhosseini, Ali, Keller, Thomas F, Körnig, Christian, Kotov, Nicholas A, Koziej, Dorota, Liang, Xing-Jie, Liu, Beibei, Liu, Sijin, Liu, Yang, Liu, Ziyao, Liz-Marzán, Luis M, Ma, Xiaowei, Machicote, Andres, Maison, Wolfgang, Mancuso, Adrian P, Megahed, Saad, Nickel, Bert, Otto, Ferdinand, Palencia, Cristina, Pascarelli, Sakura, Pearson, Arwen, Peñate-Medina, Oula, Qi, Bing, Rädler, Joachim, Richardson, Joseph J, Rosenhahn, Axel, Rothkamm, Kai, Rübhausen, Michael, Sanyal, Milan K, Schaak, Raymond E, Schlemmer, Heinz-Peter, Schmidt, Marius, Schmutzler, Oliver, Schotten, Theo, Schulz, Florian, Sood, AK, Spiers, Kathryn M, Staufer, Theresa, Stemer, Dominik M, Stierle, Andreas, Sun, Xing, Tsakanova, Gohar, Weiss, Paul S, Weller, Horst, Westermeier, Fabian, Xu, Ming, Yan, Huijie, Zeng, Yuan, Zhao, Ying, Zhao, Yuliang, Zhu, Dingcheng, Zhu, Ying, and Parak, Wolfgang J

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Physical Sciences, Bioengineering, Nanotechnology, Generic health relevance, Lasers, Nanoparticles, Radiography, Synchrotrons, X-Rays, nano-bio interface, X-ray techniques, synchrotron radiation, imaging, nanoparticles, delivery, degradation, spectroscopy, nano−bio interface, Nanoscience & Nanotechnology
Abstract

X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploited. We highlight current and upcoming advances in this direction. We describe different X-ray-based methodologies (including those performed at synchrotron light sources and X-ray free-electron lasers) and their potentials for application to investigate the nano-bio interface. The discussion is predominantly guided by asking how such methods could better help to understand and to improve nanoparticle-based drug delivery, though the concepts also apply to nano-bio interactions in general. We discuss current limitations and how they might be overcome, particularly for future use in vivo.

Published
2021

5. CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis

Author

Zhang, Tao, primary, Wahib, Ramez, additional, Zazara, Dimitra E., additional, Lücke, Jöran, additional, Shiri, Ahmad Mustafa, additional, Kempski, Jan, additional, Zhao, Lilan, additional, Agalioti, Theodora, additional, Machicote, Andres Pablo, additional, Giannou, Olympia, additional, Belios, Ioannis, additional, Jia, Rongrong, additional, Zhang, Siwen, additional, Tintelnot, Joseph, additional, Seese, Hannes, additional, Grass, Julia Kristin, additional, Mercanoglu, Baris, additional, Stern, Louisa, additional, Scognamiglio, Pasquale, additional, Fard-Aghaie, Mohammad, additional, Seeger, Philipp, additional, Wakker, Jonas, additional, Kemper, Marius, additional, Brunswig, Benjamin, additional, Duprée, Anna, additional, Lykoudis, Panagis M., additional, Pikouli, Anastasia, additional, Giorgakis, Emmanouil, additional, Stringa, Pablo, additional, Lausada, Natalia, additional, Gentilini, Maria Virginia, additional, Gondolesi, Gabriel E., additional, Bachmann, Kai, additional, Busch, Philipp, additional, Grotelüschen, Rainer, additional, Maroulis, Ioannis C., additional, Arck, Petra C., additional, Nakano, Ryosuke, additional, Thomson, Angus W., additional, Ghadban, Tarik, additional, Tachezy, Michael, additional, Melling, Nathaniel, additional, Achilles, Eike-Gert, additional, Puelles, Victor G., additional, Nickel, Felix, additional, Hackert, Thilo, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Li, Jun, additional, Gagliani, Nicola, additional, Huber, Samuel, additional, and Giannou, Anastasios D., additional

Published
2023
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6. Tr1 Cells Emerge and Suppress Effector Th17 Cells in Glomerulonephritis

Author

Soukou-Wargalla, Shiwa, primary, Kilian, Christoph, additional, Velasquez, Lis N., additional, Machicote, Andres, additional, Letz, Philine, additional, Tran, Huu Ban, additional, Domanig, Saskia, additional, Bertram, Franziska, additional, Stumme, Friederike, additional, Bedke, Tanja, additional, Giannou, Anastasios, additional, Kempski, Jan, additional, Sabihi, Morsal, additional, Song, Ning, additional, Paust, Hans-Joachim, additional, Borchers, Alina, additional, Garcia Perez, Laura, additional, Pelczar, Penelope, additional, Liu, Beibei, additional, Ergen, Can, additional, Steglich, Babett, additional, Muscate, Franziska, additional, Huber, Tobias B., additional, Panzer, Ulf, additional, Gagliani, Nicola, additional, Krebs, Christian F., additional, and Huber, Samuel, additional

Published
2023
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7. 27: INTESTINAL TRANSPLANT REJECTION IS DRIVEN BY A DISBALANCE BETWEEN REGULATORY AND INFLAMMATORY IMMUNE STATUS IN THE ALLOGRAFT

Author

Benítez, Constanza Arriola, primary, Machicote, Andres, additional, Illidge, Luis Perez, additional, Castro, Technician Araceli, additional, Fernandez, Maria Florencia, additional, Fuxman, Claudia, additional, Ramisch, Diego, additional, Rumbo, Carolina, additional, Rumbo, Martin, additional, Fainboim, Leonardo, additional, Gondolesi, Gabriel, additional, and Gentilini, María Virginia, additional

Published
2023
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8. IL-22BP controls the progression of liver metastasis in colorectal cancer

Author

Giannou, Anastasios D., primary, Kempski, Jan, additional, Zhang, Tao, additional, Lücke, Jöran, additional, Shiri, Ahmad Mustafa, additional, Zazara, Dimitra E., additional, Belios, Ioannis, additional, Machicote, Andres, additional, Seeger, Philipp, additional, Agalioti, Theodora, additional, Tintelnot, Joseph, additional, Sagebiel, Adrian, additional, Tomczak, Miriam, additional, Bauditz, Lennart, additional, Bedke, Tanja, additional, Kocheise, Lorenz, additional, Mercanoglu, Baris, additional, Fard-Aghaie, Mohammad, additional, Giorgakis, Emmanouil, additional, Lykoudis, Panagis M., additional, Pikouli, Anastasia, additional, Grass, Julia-Kristin, additional, Wahib, Ramez, additional, Bardenhagen, Jan, additional, Brunswig, Benjamin, additional, Heumann, Asmus, additional, Ghadban, Tarik, additional, Duprée, Anna, additional, Tachezy, Michael, additional, Melling, Nathaniel, additional, Arck, Petra C., additional, Stringa, Pablo, additional, Gentilini, Maria Virginia, additional, Gondolesi, Gabriel E., additional, Nakano, Ryosuke, additional, Thomson, Angus W., additional, Perez, Daniel, additional, Li, Jun, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Gagliani, Nicola, additional, Maroulis, Ioannis C., additional, and Huber, Samuel, additional

Published
2023
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9. Emergence and suppressive function of Tr1 cells in glomerulonephritis

Author

Soukou-Wargalla, Shiwa, primary, Kilian, Christoph, additional, Velasquez, Lis, additional, Machicote, Andres, additional, Bertram, Franziska, additional, Stumme, Friederike, additional, Bedke, Tanja, additional, Giannou, Anastasios, additional, Kempski, Jan, additional, Sabihi, Morsal, additional, Song, Ning, additional, Paust, Hans-Joachim, additional, Borchers, Alina, additional, Perez, Laura Garcia, additional, Pelczar, Penelope, additional, Liu, Beibei, additional, Ergen, Can, additional, Steglich, Babett, additional, Muscate, Franziska, additional, Huber, Tobias B., additional, Panzer, Ulf, additional, Gagliani, Nicola, additional, Krebs, Christian F., additional, and Huber, Samuel, additional

Published
2023
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10. Il-22 Promotes Liver Regeneration after Portal Vein Ligation

Author

Zhang, Tao, primary, Seeger, Philipp, additional, Simsek, Yashin, additional, Sabihi, Morsal, additional, Lücke, Jöran, additional, Zazara, Dimitra E., additional, Shiri, Ahmad Mustafa, additional, Kempski, Jan, additional, Blankenburg, Tom, additional, Zhao, Lilan, additional, Belios, Ioannis, additional, Machicote, Andres, additional, Mercanoglu, Baris, additional, Fard-Aghaie, Mohammad, additional, Notz, Sara, additional, Lykoudis, Panagis M., additional, Kemper, Marius, additional, Ghadban, Tarik, additional, Mann, Oliver, additional, Hackert, Thilo, additional, Izbicki, Jakob R., additional, Renné, Thomas, additional, Huber, Samuel, additional, Giannou, Anastasios D., additional, and Li, Jun, additional

Published
2023
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11. A Critical Role of the IL-22–IL-22 Binding Protein Axis in Hepatocellular Carcinoma

Author

Giannou, Anastasios D., primary, Lücke, Jöran, additional, Kleinschmidt, Dörte, additional, Shiri, Ahmad Mustafa, additional, Steglich, Babett, additional, Nawrocki, Mikolaj, additional, Zhang, Tao, additional, Zazara, Dimitra E., additional, Kempski, Jan, additional, Zhao, Lilan, additional, Giannou, Olympia, additional, Agalioti, Theodora, additional, Brockmann, Leonie, additional, Bertram, Franziska, additional, Sabihi, Morsal, additional, Böttcher, Marius, additional, Ewald, Florian, additional, Schulze, Kornelius, additional, von Felden, Johann, additional, Machicote, Andres, additional, Maroulis, Ioannis C., additional, Arck, Petra C., additional, Graß, Julia-Kristin, additional, Mercanoglu, Baris, additional, Reeh, Matthias, additional, Wolter, Stefan, additional, Tachezy, Michael, additional, Seese, Hannes, additional, Theodorakopoulou, Myrto, additional, Lykoudis, Panagis M., additional, Heumann, Asmus, additional, Uzunoglu, Faik G., additional, Ghadban, Tarik, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Li, Jun, additional, Duprée, Anna, additional, Melling, Nathaniel, additional, Gagliani, Nicola, additional, and Huber, Samuel, additional

Published
2022
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12. X-ray-Based Techniques to Study the Nano-Bio Interface

Author

Universitat Rovira i Virgili, Sanchez-Cano, Carlos; Alvarez-Puebla, Ramon A.; Abendroth, John M.; Beck, Tobias; Blick, Robert; Cao, Yuan; Caruso, Frank; Chakraborty, Indranath; Chapman, Henry N.; Chen, Chunying; Cohen, Bruce E.; Conceicao, Andre L. C.; Cormode, David P.; Cui, Daxiang; Dawson, Kenneth A.; Falkenberg, Gerald; Fan, Chunhai; Feliu, Neus; Gao, Mingyuan; Gargioni, Elisabetta; Glueer, Claus-C; Gruener, Florian; Hassan, Moustapha; Hu, Yong; Huang, Yalan; Huber, Samuel; Huse, Nils; Kang, Yanan; Khademhosseini, Ali; Keller, Thomas F.; Koernig, Christian; Kotov, Nicholas A.; Koziej, Dorota; Liang, Xing-Jie; Liu, Beibei; Liu, Sijin; Liu, Yang; Liu, Ziyao; Liz-Marzan, Luis M.; Ma, Xiaowei; Machicote, Andres; Maison, Wolfgang; Mancuso, Adrian P.; Megahed, Saad; Nickel, Bert; Otto, Ferdinand; Palencia, Cristina; Pascarelli, Sakura; Pearson, Arwen; Penate-Medina, Oula; Qi, Bing; Raedler, Joachim; Richardson, Joseph J.; Rosenhahn, Axel; Rothkamm, Kai; Rubhausen, Michael; Sanyal, Milan K.; Schaak, Raymond E.; Schlemmer, Heinz-Peter; Schmidt, Marius; Schmutzler, Oliver; Schotten, Theo; Schulz, Florian; Sood, A. K.; Spiers, Kathryn M.; Staufer, Theresa; Stemer, Dominik M.; Stierle, Andreas; Sun, Xing; Tsakanova, Gohar; Weiss, Paul S.; Weller, Horst; Westermeier, Fabian; Xu, Ming; Yan, Huijie; Zeng, Yuan; Zhao, Ying; Zhao, Yuliang; Zhu, Dingcheng; Zhu, Ying; Parak, Wolfgang J., Universitat Rovira i Virgili, and Sanchez-Cano, Carlos; Alvarez-Puebla, Ramon A.; Abendroth, John M.; Beck, Tobias; Blick, Robert; Cao, Yuan; Caruso, Frank; Chakraborty, Indranath; Chapman, Henry N.; Chen, Chunying; Cohen, Bruce E.; Conceicao, Andre L. C.; Cormode, David P.; Cui, Daxiang; Dawson, Kenneth A.; Falkenberg, Gerald; Fan, Chunhai; Feliu, Neus; Gao, Mingyuan; Gargioni, Elisabetta; Glueer, Claus-C; Gruener, Florian; Hassan, Moustapha; Hu, Yong; Huang, Yalan; Huber, Samuel; Huse, Nils; Kang, Yanan; Khademhosseini, Ali; Keller, Thomas F.; Koernig, Christian; Kotov, Nicholas A.; Koziej, Dorota; Liang, Xing-Jie; Liu, Beibei; Liu, Sijin; Liu, Yang; Liu, Ziyao; Liz-Marzan, Luis M.; Ma, Xiaowei; Machicote, Andres; Maison, Wolfgang; Mancuso, Adrian P.; Megahed, Saad; Nickel, Bert; Otto, Ferdinand; Palencia, Cristina; Pascarelli, Sakura; Pearson, Arwen; Penate-Medina, Oula; Qi, Bing; Raedler, Joachim; Richardson, Joseph J.; Rosenhahn, Axel; Rothkamm, Kai; Rubhausen, Michael; Sanyal, Milan K.; Schaak, Raymond E.; Schlemmer, Heinz-Peter; Schmidt, Marius; Schmutzler, Oliver; Schotten, Theo; Schulz, Florian; Sood, A. K.; Spiers, Kathryn M.; Staufer, Theresa; Stemer, Dominik M.; Stierle, Andreas; Sun, Xing; Tsakanova, Gohar; Weiss, Paul S.; Weller, Horst; Westermeier, Fabian; Xu, Ming; Yan, Huijie; Zeng, Yuan; Zhao, Ying; Zhao, Yuliang; Zhu, Dingcheng; Zhu, Ying; Parak, Wolfgang J.

Abstract

X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploited. We highlight current and upcoming advances in this direction. We describe different X-ray-based methodologies (including those performed at synchrotron light sources and X-ray free-electron lasers) and their potentials for application to investigate the nano–bio interface. The discussion is predominantly guided by asking how such methods could better help to understand and to improve nanoparticle-based drug delivery, though the concepts also apply to nano–bio interactions in general. We discuss current limitations and how they might be overcome, particularly for future use in vivo.

Published
2021

14. Human CD8+HLA-DR+ Regulatory T Cells, Similarly to Classical CD4+Foxp3+ Cells, Suppress Immune Responses via PD-1/PD-L1 Axis.

Author

Machicote, Andres, Belén, Santiago, Baz, Placida, Billordo, Luis A., and Fainboim, Leonardo

Abstract

We have previously identified a human CD8+HLA-DR+ regulatory T cell subset with the ability to suppress proliferation of autologous PBMCs responder cells through cell contact and CTLA-4 co-inhibitory molecule. The present study characterizes the complete phenotype of CD8+HLA-DR+ Treg cells which showed great similarities with classical CD4+ cells expressing forkhead box P3 (FOXP3). The shared features included the expression of programmed cell death protein 1 (PD-1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), C-C chemokine receptor type 4 and 5 (CCR4 and CCR5), low expression of CD127, and a memory and effector-like phenotype. CD8+HLA-DR+ Treg-induced suppression on CD8+ responder T cells was abrogated by an anti-PD1 neutralizing antibody. Anti-PD-1 did not abrogate the suppressor effect induced on responder CD4+ T cells. In addition, CD8+HLA-DR+ Treg induced a preferential death on responder CD8+ T cells. This effect was not reversed by PD-1 neutralization. After activation, most CD8+HLA-DR+ Treg acquire programmed death-ligand 1 (PD-L1) expression. Interestingly, PD-L1 may induce apoptosis through CD80 expressed on activated CD8+ responder T cells. After PBMCs stimulation, CD8+HLA-DR+ Treg cells showed an increased frequency of IFN-γ and TNFα positive cells and higher degranulation. These data strongly argue against CD8+HLA-DR+ Treg being exhausted cells. Overall, the data presented in this study indicate that CD8+HLA-DR+ Treg and CD4+FOXP3+ Treg share phenotypic and functional features, which may provide cues to similar involvements in the control of antitumor immune responses and autoimmunity. [ABSTRACT FROM AUTHOR]

Published
2018
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16. Human CD8 + HLA-DR + Regulatory T Cells, Similarly to Classical CD4 + Foxp3 + Cells, Suppress Immune Responses via PD-1/PD-L1 Axis.

Author

Machicote A, Belén S, Baz P, Billordo LA, and Fainboim L

Subjects
CD8-Positive T-Lymphocytes cytology, Female, HLA-DR Antigens immunology, Humans, Interferon-gamma immunology, Male, T-Lymphocytes, Regulatory cytology, Tumor Necrosis Factor-alpha immunology, Apoptosis immunology, B7-H1 Antigen immunology, CD8-Positive T-Lymphocytes immunology, Programmed Cell Death 1 Receptor immunology, T-Lymphocytes, Regulatory immunology
Abstract

We have previously identified a human CD8 + HLA-DR + regulatory T cell subset with the ability to suppress proliferation of autologous PBMCs responder cells through cell contact and CTLA-4 co-inhibitory molecule. The present study characterizes the complete phenotype of CD8 + HLA-DR + Treg cells which showed great similarities with classical CD4 + cells expressing forkhead box P3 (FOXP3). The shared features included the expression of programmed cell death protein 1 (PD-1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), C-C chemokine receptor type 4 and 5 (CCR4 and CCR5), low expression of CD127, and a memory and effector-like phenotype. CD8 + HLA-DR + Treg-induced suppression on CD8 + responder T cells was abrogated by an anti-PD1 neutralizing antibody. Anti-PD-1 did not abrogate the suppressor effect induced on responder CD4 + T cells. In addition, CD8 + HLA-DR + Treg induced a preferential death on responder CD8 + T cells. This effect was not reversed by PD-1 neutralization. After activation, most CD8 + HLA-DR + Treg acquire programmed death-ligand 1 (PD-L1) expression. Interestingly, PD-L1 may induce apoptosis through CD80 expressed on activated CD8 + responder T cells. After PBMCs stimulation, CD8 + HLA-DR + Treg cells showed an increased frequency of IFN-γ and TNFα positive cells and higher degranulation. These data strongly argue against CD8 + HLA-DR + Treg being exhausted cells. Overall, the data presented in this study indicate that CD8 + HLA-DR + Treg and CD4 + FOXP3 + Treg share phenotypic and functional features, which may provide cues to similar involvements in the control of antitumor immune responses and autoimmunity.

Published
2018
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