Search

Your search keyword '"MUNTEAN, DANINA MIRELA"' showing total 24 results
Start Over Author "MUNTEAN, DANINA MIRELA" Publication Year Range Last 50 years
24 results on '"MUNTEAN, DANINA MIRELA"'

2. Mitochondrial DNA and Inflammation Are Associated with Cerebral Vessel Remodeling and Early Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus.

Author

Petrica, Ligia, Gadalean, Florica, Muntean, Danina Mirela, Jianu, Dragos Catalin, Vlad, Daliborca, Dumitrascu, Victor, Bob, Flaviu, Milas, Oana, Suteanu-Simulescu, Anca, Glavan, Mihaela, Ursoniu, Sorin, Balint, Lavinia, Mogos-Stefan, Maria, Ienciu, Silvia, Cretu, Octavian Marius, Popescu, Roxana, Gluhovschi, Cristina, Iancu, Lavinia, and Vlad, Adrian

Subjects
DIABETIC nephropathies, MITOCHONDRIAL DNA, TYPE 2 diabetes, CD54 antigen, NADH dehydrogenase, INTERNAL carotid artery, TUMOR necrosis factors
Abstract

Cerebrovascular disease accounts for major neurologic disabilities in patients with type 2 diabetes mellitus (DM). A potential association of mitochondrial DNA (mtDNA) and inflammation with cerebral vessel remodeling in patients with type 2 DM was evaluated. A cohort of 150 patients and 30 healthy controls were assessed concerning urinary albumin/creatinine ratio (UACR), synaptopodin, podocalyxin, kidney injury molecule-1 (KIM-1), N-acetyl-β-(D)-glucosaminidase (NAG), interleukins IL-17A, IL-18, IL-10, tumor necrosis factor-alpha (TNFα), intercellular adhesion molecule-1 (ICAM-1). MtDNA-CN and nuclear DNA (nDNA) were quantified in peripheral blood and urine by qRT-PCR. Cytochrome b (CYTB) gene, subunit 2 of NADH dehydrogenase (ND2), and beta 2 microglobulin nuclear gene (B2M) were assessed by TaqMan assays. mtDNA-CN was defined as the ratio of the number of mtDNA/nDNA copies, through analysis of the CYTB/B2M and ND2/B2M ratio; cerebral Doppler ultrasound: intima-media thickness (IMT)—the common carotid arteries (CCAs), the pulsatility index (PI) and resistivity index (RI)- the internal carotid arteries (ICAs) and middle cerebral arteries (MCAs), the breath-holding index (BHI). The results showed direct correlations of CCAs-IMT, PI-ICAs, PI-MCAs, RI-ICAs, RI-MCAs with urinary mtDNA, IL-17A, IL-18, TNFα, ICAM-1, UACR, synaptopodin, podocalyxin, KIM-1, NAG, and indirect correlations with serum mtDNA, IL-10. BHI correlated directly with serum IL-10, and serum mtDNA, and negatively with serum IL-17A, serum ICAM-1, and NAG. In neurologically asymptomatic patients with type 2 DM cerebrovascular remodeling and impaired cerebrovascular reactivity may be associated with mtDNA variations and inflammation from the early stages of diabetic kidney disease. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Mitochondrial DNA Changes in Blood and Urine Display a Specific Signature in Relation to Inflammation in Normoalbuminuric Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Author

Petrica, Ligia, primary, Vlad, Adrian, additional, Gadalean, Florica, additional, Muntean, Danina Mirela, additional, Vlad, Daliborca, additional, Dumitrascu, Victor, additional, Bob, Flaviu, additional, Milas, Oana, additional, Suteanu-Simulescu, Anca, additional, Glavan, Mihaela, additional, Jianu, Dragos Catalin, additional, Ursoniu, Sorin, additional, Balint, Lavinia, additional, Mogos-Stefan, Maria, additional, Ienciu, Silvia, additional, Cretu, Octavian Marius, additional, and Popescu, Roxana, additional

Published
2023
Full Text
View/download PDF

13. IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action

Author

Lecour, Sandrine, Andreadou, Ioanna, Bøtker, Hans Erik, Davidson, Sean M., Heusch, Gerd, Ruiz-Meana, Marisol, Schulz, Rainer, Zuurbier, Coert J., Ferdinandy, Péter, Hausenloy, Derek J., Adamovski, Pavle, Batirel, Saime, Barteková, Monika, Bertrand, Luc, Beauloye, Christophe, Biedermann, David, Borutaite, Vilmante, Chlopicki, Stefan, Dambrova, Maija, Devaux, Yvan, Di Lisa, Fabio, Djuric, Dragan, Erlinge, David, Falcao-Pires, Ines, Galatou, Eleftheria, Garcia-Sosa, Alfonso, Girao, Henrique, Giricz, Zoltan, Gyongyosi, Mariann, Healy, Donagh, Jakovljevic, Vladimir, Jovanic, Jelena, Kararigas, George, Kerkal, Risto, Kolar, Frantisek, Kwak, Brenda, Leszek, Przemysław, Liepinsh, Edgars, Lonborg, Jacob, Longnus, Sarah, Marinovic, Jasna, Muntean, Danina Mirela, Nezic, Lana, Ovize, Michel, Pagliaro, Pasquale, Da Costa Gomes, Clarissa Pedrosa, Pernow, John, Persidis, Andreas, Pischke, Søren Erik, Podesser, Bruno, Potočnjak, Ines, Prunier, Fabrice, Ravingerova, Tanya, Serban, Alina, Slagsvold, Katrine, van Royen, Niels, Turan, Belma, Vendelin, Marko, Walsh, Stewart, Zidar, Nace, Yellon, Derek, Institut Català de la Salut, [Lecour S] Department of Medicine, Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa. [Andreadou I] Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece. [Bøtker HE] Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark. [Davidson SM] The Hatter Cardiovascular Institute, University College London, London, UK. [Heusch G] Institute for Pathophysiology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany. [Ruiz-Meana M] Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores], medicine.medical_specialty, enfermedades cardiovasculares::enfermedades vasculares::daño por reperfusión [ENFERMEDADES], genetic structures, Physiology, Medizin, Myocardial Infarction, Ischemia, Psychological intervention, Infarction, 610 Medicine & health, Drug development, Cardioprotection, Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial Infarction [DISEASES], Reperfusion, Other subheadings::Other subheadings::/prevention & control [Other subheadings], Physiology (medical), medicine, Animals, Humans, Myocardial infarction, Cardiovascular Diseases::Vascular Diseases::Reperfusion Injury [DISEASES], Intensive care medicine, Practical Guideline, Heart Failure, business.industry, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Reperfusió miocardíaca, Cor - Malalties - Prevenció, medicine.disease, enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::infarto de miocardio [ENFERMEDADES], Cor - Malalties - Tractament, Reperfusion Injury, Heart failure, Cardiology and Cardiovascular Medicine, business, Reperfusion injury
Abstract

Cardioprotection; Drug development; Infarction Cardioprotección; Desarrollo de fármacos; Infarto Cardioprotecció; Desenvolupament de fàrmacs; Infart Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against acute ischemia/reperfusion injury to reduce myocardial infarct size and prevent the onset of HF in patients presenting with AMI. However, the clinical translation of cardioprotective interventions that have proven to be beneficial in preclinical animal studies, has been challenging. One likely major reason for this failure to translate cardioprotection into patient benefit is the lack of rigorous and systematic in vivo preclinical assessment of the efficacy of promising cardioprotective interventions prior to their clinical evaluation. To address this, we propose an in vivo set of step-by-step criteria for IMproving Preclinical Assessment of Cardioprotective Therapies (‘IMPACT’), for investigators to consider adopting before embarking on clinical studies, the aim of which is to improve the likelihood of translating novel cardioprotective interventions into the clinical setting for patient benefit. This article is based on the work from COST Action EU-CARDIOPROTECTION CA16225 supported by COST (European Cooperation in Science and Technology). DJH is supported by the Duke-National University Singapore Medical School, Singapore Ministry of Health’s National Medical Research Council under its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/CGAug16C006). SL is supported by grants from the South African Department of Science and Technology and the South African National Research Foundation. SMD is supported by grants from the British Heart Foundation (PG/19/51/34493 and PG/16/85/32471). GH is supported by the German Research Foundation (SFB 1116 B8). MRM is supported by the Spanish Institute of Health Carlos III (FIS PI19/01196 and CIBER-CV). RS is supported by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [Project number 268555672—SFB 1213, Project B05]. PF is supported by the National Research, Development and Innovation Office of Hungary (Research Excellence Program—TKP, National Heart Program NVKP 16-1-2016-0017) and by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the Therapeutic Development thematic program of the Semmelweis University.

Published
2021
Full Text
View/download PDF

16. Identification of Resveratrol as Bioactive Compound of Propolis from Western Romania and Characterization of Phenolic Profile and Antioxidant Activity of Ethanolic Extracts

Author

Duca, Alexandra, primary, Sturza, Adrian, additional, Moacă, Elena-Alina, additional, Negrea, Monica, additional, Lalescu, Virgil-Dacian, additional, Lungeanu, Diana, additional, Dehelean, Cristina-Adriana, additional, Muntean, Danina-Mirela, additional, and Alexa, Ersilia, additional

Published
2019
Full Text
View/download PDF

17. Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride

Author

Pavel, Ioana Zinuca, primary, Csuk, Rene, additional, Danciu, Corina, additional, Avram, Stefana, additional, Baderca, Flavia, additional, Cioca, Andreea, additional, Moacă, Elena-Alina, additional, Mihali, Ciprian-Valentin, additional, Pinzaru, Iulia, additional, Muntean, Danina Mirela, additional, and Dehelean, Cristina Adriana, additional

Published
2019
Full Text
View/download PDF

21. ASSESSMENT OF LIPID PROFILE OF EIGHT PROPOLIS SAMPLES FROM WESTERN ROMANIA.

Author

DUCA, ALEXANDRA, ALEXA, ERSILIA, DEHELEAN, CRISTINA ADRIANA, ŞOICA, CODRUŢA, DANCIU, CORINA, POPESCU, IULIANA, COCAN, ILEANA, LALESCU, DACIAN, and MUNTEAN, DANINA MIRELA

Subjects
ESSENTIAL fatty acids, UNSATURATED fatty acids, LIPIDS, FATTY acids, PROPOLIS, LIPID analysis
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
Full Text
View/download PDF

23. ASSESSMENT OF THE ANTIOXIDANT EFFECT OF A MASLINIC ACID DERIVATIVE IN AN EXPERIMENTAL MODEL OF ACUTE INFLAMMATION.

Author

PAVEL, IOANA ZINUCA, PÂRVU, ALINA ELENA, DEHELEAN, CRISTINA ADRIANA, VLASE, LAURIAN, CSUK, RENÉ, and MUNTEAN, DANINA MIRELA

Subjects
INFLAMMATION treatment, ANTIOXIDANTS, ACID derivatives, TREATMENT effectiveness, ANTIVIRAL agents
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

24. BIOENERGETIC CHARACTERIZATION OF H9C2 CELLS USING THE EXTRACELLULAR FLUX ANALYZER.

Author

Scurtu I, Sturza A, Pavel IZ, Popescu R, Privistirescu A, Duicu OM, and Muntean DM

Subjects
Animals, Cell Line, Rats, Reference Standards, Energy Metabolism, Glycolysis, Metabolic Flux Analysis instrumentation, Metabolic Flux Analysis methods, Mitochondria metabolism, Myoblasts, Cardiac metabolism
Abstract

Unlabelled: The aim of the present work was to standardize the working methodology for assessing the bioenergetic profile of H9c2 cardiomyoblasts cells, with reference to the optimization of cell seeding number and the establishment of favorable concentrations for the classic modulators of mitochondrial respiratory function, in particular the one of a classical uncoupler, FCCP., Material and Methods: The extracellular flux analyzer (XF, Seahorse Bioscience) is a novel high-throughput instrument able to monitor the metabolism of living cells by simultaneously measuring mitochondrial respiration and glycolysis. The in vitro platform will be further used to better understand the pathophysiology and the unrecognized side effects of drugs currently used in the therapy of major cardiovascular diseases., Conclusions: In the long run, characterization of novel pharmacological agents' effects on other cell lines, including tumoral ones, will be also considered.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results