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Your search keyword '"Loussouarn, Delphine"' showing total 287 results
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287 results on '"Loussouarn, Delphine"'

2. Deep Learning for Detecting BRCA Mutations in High-Grade Ovarian Cancer Based on an Innovative Tumor Segmentation Method From Whole Slide Images

Author

Bourgade, Raphaël, Rabilloud, Noémie, Perennec, Tanguy, Pécot, Thierry, Garrec, Céline, Guédon, Alexis F., Delnatte, Capucine, Bézieau, Stéphane, Lespagnol, Alexandra, de Tayrac, Marie, Henno, Sébastien, Sagan, Christine, Toquet, Claire, Mosnier, Jean-François, Kammerer-Jacquet, Solène-Florence, and Loussouarn, Delphine

Published
2023
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3. Diagnostic des sarcomes utérins et tumeurs mésenchymateuses utérines rares à potentiel de malignité. Référentiels du Groupe Sarcome Français et des Tumeurs Rares Gynécologiques

Author

Croce, Sabrina, Devouassoux-Shisheboran, Mojgan, Pautier, Patricia, Ray-Coquard, Isabelle, Treilleux, Isabelle, Neuville, Agnès, Arnould, Laurent, Just, Pierre-Alexandre, Le frere Belda, Marie Aude, Averous, Gerlinde, Leroux, Agnès, Bataillon, Guillaume, Mery, Eliane, Loussouarn, Delphine, Weinbreck, Nicolas, Le Guellec, Sophie, Mishellany, Florence, Morice, Philippe, Guyon, Frédéric, and Genestie, Catherine

Published
2023
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6. Phenotypic discordance between primary and metastatic breast cancer in the large-scale real-life multicenter French ESME cohort

Author

Grinda, Thomas, Joyon, Natacha, Lusque, Amélie, Lefèvre, Sarah, Arnould, Laurent, Penault-Llorca, Frédérique, Macgrogan, Gaëtan, Treilleux, Isabelle, Vincent-Salomon, Anne, Haudebourg, Juliette, Maran-Gonzalez, Aurélie, Charafe-Jauffret, Emmanuelle, Courtinard, Coralie, Franchet, Camille, Verriele, Véronique, Brain, Etienne, Tas, Patrick, Blanc-Fournier, Cécile, Leroux, Agnès, Loussouarn, Delphine, Berghian, Anca, Brabencova, Eva, Ghnassia, Jean Pierre, Scoazec, Jean-Yves, Delaloge, Suzette, Filleron, Thomas, and Lacroix-Triki, Magali

Published
2021
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7. Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study

Author

Li, Bryan K., Vasiljevic, Alexandre, Dufour, Christelle, Yao, Fupan, Ho, Ben L. B., Lu, Mei, Hwang, Eugene I., Gururangan, Sridharan, Hansford, Jordan R., Fouladi, Maryam, Nobusawa, Sumihito, Laquerriere, Annie, Delisle, Marie-Bernadette, Fangusaro, Jason, Forest, Fabien, Toledano, Helen, Solano-Paez, Palma, Leary, Sarah, Birks, Diane, Hoffman, Lindsey M., Szathmari, Alexandru, Faure-Conter, Cécile, Fan, Xing, Catchpoole, Daniel, Zhou, Li, Schultz, Kris Ann P., Ichimura, Koichi, Gauchotte, Guillaume, Jabado, Nada, Jones, Chris, Loussouarn, Delphine, Mokhtari, Karima, Rousseau, Audrey, Ziegler, David S., Tanaka, Shinya, Pomeroy, Scott L., Gajjar, Amar, Ramaswamy, Vijay, Hawkins, Cynthia, Grundy, Richard G., Hill, D. Ashley, Bouffet, Eric, Huang, Annie, and Jouvet, Anne

Published
2020
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8. Deep Learning Methodologies Applied to Digital Pathology in Prostate Cancer: A Systematic Review

Author

Rabilloud, Noémie, primary, Allaume, Pierre, additional, Acosta, Oscar, additional, De Crevoisier, Renaud, additional, Bourgade, Raphael, additional, Loussouarn, Delphine, additional, Rioux-Leclercq, Nathalie, additional, Khene, Zine-eddine, additional, Mathieu, Romain, additional, Bensalah, Karim, additional, Pecot, Thierry, additional, and Kammerer-Jacquet, Solene-Florence, additional

Published
2023
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10. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Author

Lohard, Steven, Bourgeois, Nathalie, Maillet, Laurent, Gautier, Fabien, Fétiveau, Aurélie, Lasla, Hamza, Nguyen, Frédérique, Vuillier, Céline, Dumont, Alison, Moreau-Aubry, Agnès, Frapin, Morgane, David, Laurent, Loussouarn, Delphine, Kerdraon, Olivier, Campone, Mario, Jézéquel, Pascal, Juin, Philippe P., and Barillé-Nion, Sophie

Published
2020
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12. CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

Author

Gross, Catharina C., Meyer, Céline, Bhatia, Urvashi, Yshii, Lidia, Kleffner, Ilka, Bauer, Jan, Tröscher, Anna R., Schulte-Mecklenbeck, Andreas, Herich, Sebastian, Schneider-Hohendorf, Tilman, Plate, Henrike, Kuhlmann, Tanja, Schwaninger, Markus, Brück, Wolfgang, Pawlitzki, Marc, Laplaud, David-Axel, Loussouarn, Delphine, Parratt, John, Barnett, Michael, Buckland, Michael E., Hardy, Todd A., Reddel, Stephen W., Ringelstein, Marius, Dörr, Jan, Wildemann, Brigitte, Kraemer, Markus, Lassmann, Hans, Höftberger, Romana, Beltrán, Eduardo, Dornmair, Klaus, Schwab, Nicholas, Klotz, Luisa, Meuth, Sven G., Martin-Blondel, Guillaume, Wiendl, Heinz, and Liblau, Roland

Published
2019
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14. Figure S6 from Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity

Author

Oizel, Kristell, primary, Chauvin, Cynthia, primary, Oliver, Lisa, primary, Gratas, Catherine, primary, Geraldo, Fanny, primary, Jarry, Ulrich, primary, Scotet, Emmanuel, primary, Rabe, Marion, primary, Alves-Guerra, Marie-Clotilde, primary, Teusan, Raluca, primary, Gautier, Fabien, primary, Loussouarn, Delphine, primary, Compan, Vincent, primary, Martinou, Jean-Claude, primary, Vallette, François M., primary, and Pecqueur, Claire, primary

Published
2023
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15. Supplementary Tables from Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity

Author

Oizel, Kristell, primary, Chauvin, Cynthia, primary, Oliver, Lisa, primary, Gratas, Catherine, primary, Geraldo, Fanny, primary, Jarry, Ulrich, primary, Scotet, Emmanuel, primary, Rabe, Marion, primary, Alves-Guerra, Marie-Clotilde, primary, Teusan, Raluca, primary, Gautier, Fabien, primary, Loussouarn, Delphine, primary, Compan, Vincent, primary, Martinou, Jean-Claude, primary, Vallette, François M., primary, and Pecqueur, Claire, primary

Published
2023
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17. Diagnostic des sarcomes utérins et tumeurs mésenchymateuses utérines rares à potentiel de malignité. Référentiels du Groupe Sarcome Français et des Tumeurs Rares Gynécologiques

Author

Croce, Sabrina, Devouassoux-Shisheboran, Mojgan, Pautier, Patricia, Ray-Coquard, Isabelle, Treilleux, Isabelle, Neuville, Agnès, Arnould, Laurent, Just, Pierre-Alexandre, Le frere Belda, Marie Aude, Averous, Gerlinde, Leroux, Agnès, Bataillon, Guillaume, Mery, Eliane, Loussouarn, Delphine, Weinbreck, Nicolas, Le Guellec, Sophie, Mishellany, Florence, Morice, Philippe, Guyon, Frédéric, and Genestie, Catherine

Abstract

Le panorama des sarcomes utérins se complexifie de plus en plus avec la description de nouvelles entités associées à des altérations moléculaires récurrentes. Les léiomyosarcomes et les sarcomes utérins indifférenciés sont des sarcomes à génomique complexe. Les sarcomes du stroma endométrial de bas grade et de haut grade, d’autres sarcomes associés aux transcrits de fusion (tels que NTRK, PDGFB, ALK, RET ROS1) et le sarcome utérin déficient en SMARCA4 sont des sarcomes à génomique simple. Le léiomyosarcome est le sarcome utérin le plus fréquent suivi par les sarcomes du stroma endométrial. Il existe trois différents sous-types histologiques de léiomyosarcome (fusiforme, myxoïde, épithélioïde), les léiomyosarcomes myxoïde et épithélioïde étant plus agressifs que le léiomyosarcome fusiforme. La distinction entre un sarcome du stroma endométrial de bas grade et de haut grade est tout d’abord morphologique et immunohistochimique. La mise en évidence des transcrits de fusions aide au diagnostic. Définitivement reconnu comme entité distincte parmi les tumeurs mésenchymateuses gynécologiques, le PECome utérin fait partie des tumeurs rares. Grâce à des algorithmes d’évaluation du risque, les PEComes utérins sont différentiés en borderlineet en malins. Le rhabdomyosarcome embryonnaire du col utérin survient typiquement chez l’enfant, mais peut s’observer également chez la femme adulte. Le rhabdomyosarcome embryonnaire du col utérin est presque toujours DICER1 muté, à la différence de celui du vagin qui est DICER1 sauvage, et de l’adénosarcome qui peut être DICER1 muté mais en moindre fréquence. Parmi les entités émergentes, les sarcomes associés aux transcrits de fusion impliquant les gènes NTRK, ALK, PDGFBbénéficient d’une thérapeutique ciblée. L’intégration des données moléculaires avec l’histologie et la clinique permet de mieux identifier les sarcomes utérins afin de mieux les traiter.

Published
2024
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21. Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group

Author

Croce, Sabrina, primary, Devouassoux-Shisheboran, Mojgan, additional, Pautier, Patricia, additional, Ray-Coquard, Isabelle, additional, Treilleux, Isabelle, additional, Neuville, Agnès, additional, Arnould, Laurent, additional, Just, Pierre-Alexandre, additional, Belda, Marie Aude Le Frere, additional, Averous, Gerlinde, additional, Leroux, Agnès, additional, Mery, Eliane, additional, Loussouarn, Delphine, additional, Weinbreck, Nicolas, additional, Le Guellec, Sophie, additional, Mishellany, Florence, additional, Morice, Philippe, additional, Guyon, Frédéric, additional, and Genestie, Catherine, additional

Published
2022
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22. Mise à jour 2014 des recommandations du GEFPICS pour l’évaluation du statut HER2 dans les cancers du sein en France

Author

Penault-Llorca, Frédérique, Vincent-Salomon, Anne, MacGrogan, Gaëtan, Roger, Pascal, Treilleux, Isabelle, Valent, Alexander, Mathieu, Marie-Christine, Antoine, Martine, Becette, Véronique, Bor, Catherine, Brabencova, Eva, Charafe-Jauffret, Emmanuelle, Chenard, Marie-Pierre, Dauplat, Marie-Mélanie, Delrée, Paul, Devouassoux, Mojgan, Fiche, Maryse, Fondrevelle, Marie-Eve, Fridman, Viviana, Garbar, Christian, Genin, Pascal, Ghnassia, Jean-Pierre, Haudebourg, Juliette, Laberge-Le Couteulx, Sophie, Loussouarn, Delphine, Maran-Gonzalez, Aurélie, Marcy, Myriam, Michenet, Patrick, Poulet, Bruno, Sagan, Christine, Trassard, Martine, Verriele, Véronique, Arnould, Laurent, and Lacroix-Triki, Magali

Published
2014
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23. Recommandations du GEFPICS concernant la phase pré-analytique pour l’évaluation de HER2 et des récepteurs hormonaux dans le cancer du sein : mise à jour 2014

Author

MacGrogan, Gaëtan, Mathieu, Marie-Christine, Poulet, Bruno, Penault-Llorca, Frédérique, Vincent-Salomon, Anne, Roger, Pascal, Treilleux, Isabelle, Valent, Alexander, Antoine, Martine, Becette, Véronique, Bor, Catherine, Brabencova, Eva, Charafe-Jauffret, Emmanuelle, Chenard, Marie-Pierre, Dauplat, Marie-Mélanie, Delrée, Paul, Devouassoux, Mojgan, Fiche, Maryse, Fondrevelle, Marie-Eve, Fridman, Viviana, Garbar, Christian, Genin, Pascal, Ghnassia, Jean-Pierre, Haudebourg, Juliette, Laberge-Le Couteulx, Sophie, Loussouarn, Delphine, Maran-Gonzalez, Aurélie, Marcy, Myriam, Michenet, Patrick, Sagan, Christine, Trassard, Martine, Verriele, Véronique, Arnould, Laurent, and Lacroix-Triki, Magali

Published
2014
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24. A Multigene Signature Associated with Progression-Free Survival after Treatment for IDH Mutant and 1p/19q Codeleted Oligodendrogliomas.

Author

Gilhodes, Julia, Meola, Adèle, Cabarrou, Bastien, Peyraga, Guillaume, Dehais, Caroline, Figarella-Branger, Dominique, Ducray, François, Maurage, Claude-Alain, Loussouarn, Delphine, Uro-Coste, Emmanuelle, and Cohen-Jonathan Moyal, Elizabeth

Subjects
CANCER chemotherapy, MULTIVARIATE analysis, GLIOMAS, GENE expression, TREATMENT effectiveness, GENES, SURVIVAL analysis (Biometry), PROGRESSION-free survival, OXIDOREDUCTASES, RADIOTHERAPY, LONGITUDINAL method
Abstract

Simple Summary: Since the publication in 2016 of the WHO's classification of primary brain tumors according to their histopathology but also their molecular status (IDH, 1p/19q codeletion), oligodendrogliomas defined by the presence of the 1p/19q codeletion have been clearly identified as having a better prognosis. However, the response to treatment of 1p/19q codeleted gliomas remains heterogeneous. Very few studies have investigated the genetic profiles of these tumors, particularly with regard to their response to treatment (radiotherapy and chemotherapy). Our analyses revealed a gene signature composed of eight genes involved in metabolism, immunity, and extracellular matrix organization pathways that were associated with a poor response to treatment for 1p/19q codeleted tumors. This signature could be used in the future to identify patients who need more intensive treatment, potentially with inhibitors of these pathways. Background. IDH mutant and 1p/19q codeleted oligodendrogliomas are the gliomas associated with the best prognosis. However, despite their sensitivity to treatment, patient survival remains heterogeneous. We aimed to identify gene expressions associated with response to treatment from a national cohort of patients with oligodendrogliomas, all treated with radiotherapy +/− chemotherapy. Methods. We extracted total RNA from frozen tumor samples and investigated enriched pathways using KEGG and Reactome databases. We applied a stability selection approach based on subsampling combined with the lasso-pcvl algorithm to identify genes associated with progression-free survival and calculate a risk score. Results. We included 68 patients with oligodendrogliomas treated with radiotherapy +/− chemotherapy. After filtering, 1697 genes were obtained, including 134 associated with progression-free survival: 35 with a better prognosis and 99 with a poorer one. Eight genes (ST3GAL6, QPCT, NQO1, EPHX1, CST3, S100A8, CHI3L1, and OSBPL3) whose risk score remained statistically significant after adjustment for prognostic factors in multivariate analysis were selected in more than 60% of cases were associated with shorter progression-free survival. Conclusions. We found an eight-gene signature associated with a higher risk of rapid relapse after treatment in patients with oligodendrogliomas. This finding could help clinicians identify patients who need more intensive treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Prognostic value of hPG80 (circulating progastrin) in IDH-wild type glioblastoma treated with radio-chemotherapy.

Author

Doucet, Ludovic, primary, Cailleteau, Axel, additional, Vaugier, Loig, additional, Gourmelon, Carole, additional, Bureau, Mathilde, additional, Salaud, Celine, additional, Roualdes, Vincent, additional, Samarut, Edouard, additional, Aumont, Maud, additional, Zenatri, Morgan, additional, Loussouarn, Delphine, additional, Quillien, Veronique, additional, Bocquet, Francois, additional, Payen-Gay, Lea, additional, Mahi, Younes, additional, Prieur, Alexandre, additional, Robert, Marie, additional, and Frenel, Jean-Sebastien, additional

Published
2022
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26. Pharmacological targeting of apelin impairs glioblastoma growth

Author

Harford-Wright, Elizabeth, Andre-Gregoire, Gwennan, Jacobs, Kathryn A, Treps, Lucas, Le Gonidec, Sophie, Leclair, Heloise M, Gonzalez-Diest, Sara, Roux, Quentin, Guillonneau, François, Loussouarn, Delphine, Oliver, Lisa, Vallette, François M, Foufelle, Fabienne, Valet, Philippe, Davenport, Anthony P, Glen, Robert C, Bidere, Nicolas, and Gavard, Julie

Published
2017
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27. Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co‐deleted anaplastic gliomas

Author

Bielle, Franck, Ducray, François, Mokhtari, Karima, Dehais, Caroline, Adle‐Biassette, Homa, Carpentier, Catherine, Chanut, Anaïs, Polivka, Marc, Poggioli, Sylvie, Rosenberg, Shai, Giry, Marine, Marie, Yannick, Duyckaerts, Charles, Sanson, Marc, Figarella‐Branger, Dominique, Idbaih, Ahmed, Desenclos, Christine, Sevestre, Henri, Menei, Philippe, Rousseau, Audrey, Godard, Joel, Viennet, Gabriel, Carpentier, Antoine, Eimer, Sandrine, Loiseau, Hugues, Dam‐Hieu, Phong, Quintin‐Roué, Isabelle, Guillamo, Jean‐Sebastien, Lechapt‐Zalcman, Emmanuelle, Kemeny, Jean‐Louis, Khallil, Toufik, Cazals‐Hatem, Dominique, Faillot, Thierry, Carpiuc, Ioana, Richard, Pomone, Le Guerinel, Caroline, Gaultier, Claude, Tortel, Marie‐Christine, Aubriot‐Lorton, Marie‐Hélène, Ghiringhelli, François, Adam, Clovis, Parker, Fabrice, Maurage, Claude‐Alain, Ramirez, Carole, Marcel Gueye, Edouard, Labrousse, François, Jouvet, Anne, Chinot, Olivier, Bauchet, Luc, Rigau, Valérie, Beauchesne, Patrick, Gauchotte, Guillaume, Campone, Mario, Loussouarn, Delphine, Fontaine, Denys, Vandenbos, Fanny, Blechet, Claire, Fesneau, Mélanie, Yves Delattre, Jean, Elouadhani‐Hamdi, Selma, Ricard, Damien, Larrieu‐Ciron, Delphine, Levillain, Pierre‐Marie, Colin, Philippe, Diebold, Marie‐Danièle, Chiforeanu, Danchristian, Vauléon, Elodie, Langlois, Olivier, Laquerrière, Annie, Motsuo Fotso, Marie Janette, Peocʼh, Michel, Andraud, Marie, Runavot, Gwenaelle, Chenard, Marie‐Pierre, Noel, Georges, Gaillard, Stéphane, Villa, Chiara, Desse, Nicolas, Cohen‐Moyal, Elisabeth, Uro‐Coste, Emmanuelle, and Dhermain, Frédéric

Published
2017
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29. A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Author

Croce, Sabrina, Devouassoux-Shisheboran, Mojgan, Pautier, Patricia, Ray-Coquard, Isabelle, Treilleux, Isabelle, Neuville, Agnès, Arnould, Laurent, Just, Pierre-Alexandre, Belda, Marie Aude Le Frere, Averous, Gerlinde, Leroux, Agnès, Mery, Eliane, Loussouarn, Delphine, Weinbreck, Nicolas, Le Guellec, Sophie, Mishellany, Florence, Morice, Philippe, Guyon, Frédéric, Genestie, Catherine, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)

Subjects
radioiodination, radiofluorination, tyrosine analogs, TIC(OH), PET/SPECT imaging, [SDV]Life Sciences [q-bio], Drug Discovery, Pharmaceutical Science, Molecular Medicine
Abstract

The use of radiolabeled non-natural amino acids can provide high contrast SPECT/PET metabolic imaging of solid tumors. Among them, radiohalogenated tyrosine analogs (i.e., [123I]IMT, [18F]FET, [18F]FDOPA, [123I]8-iodo-L-TIC(OH), etc.) are of particular interest. While radioiodinated derivatives, such as [123I]IMT, are easily available via electrophilic aromatic substitutions, the production of radiofluorinated aryl tyrosine analogs was a long-standing challenge for radiochemists before the development of innovative radiofluorination processes using arylboronate, arylstannane or iodoniums salts as precursors. Surprisingly, despite these methodological advances, no radiofluorinated analogs have been reported for [123I]8-iodo-L-TIC(OH), a very promising radiotracer for SPECT imaging of prostatic tumors. This work describes a convenient synthetic pathway to obtain new radioiodinated and radiofluorinated derivatives of TIC(OH), as well as their non-radiolabeled counterparts. Using organotin compounds as key intermediates, [125I]5-iodo-L-TIC(OH), [125I]6-iodo-L-TIC(OH) and [125I]8-iodo-L-TIC(OH) were efficiently prepared with good radiochemical yield (RCY, 51–78%), high radiochemical purity (RCP, >98%), molar activity (Am, >1.5–2.9 GBq/µmol) and enantiomeric excess (e.e. >99%). The corresponding [18F]fluoro-L-TIC(OH) derivatives were also successfully obtained by radiofluorination of the organotin precursors in the presence of tetrakis(pyridine)copper(II) triflate and nucleophilic [18F]F− with 19–28% RCY d.c., high RCP (>98.9%), Am (20–107 GBq/µmol) and e.e. (>99%).

Published
2021

31. A phase II randomised study of preoperative trastuzumab alone or combined with everolimus in patients with early HER2-positive breast cancer and predictive biomarkers (RADHER trial)

Author

Campone, Mario, primary, Bachelot, Thomas, additional, Treilleux, Isabelle, additional, Pistilli, Barbara, additional, Salleron, Julia, additional, Seegers, Valérie, additional, Arnedos, Monica, additional, Loussouarn, Delphine, additional, Wang, Qing, additional, Vanlemmens, Laurence, additional, Jimenez, Marta, additional, Rios, Maria, additional, Diéras, Véronique, additional, Leroux, Agnès, additional, Paintaud, Gilles, additional, Rezai, Keyvan, additional, André, Fabrice, additional, Lion, Maëva, additional, and Merlin, Jean-Louis, additional

Published
2021
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32. Prognostic Relevance of Histomolecular Classification of Diffuse Adult High-Grade Gliomas with Necrosis

Author

Figarella-Branger, Dominique, Mokhtari, Karima, Colin, Carole, Uro-Coste, Emmanuelle, Jouvet, Anne, Dehais, Caroline, Carpentier, Catherine, Villa, Chiara, Maurage, Claude-Alain, Eimer, Sandrine, Polivka, Marc, Vignaud, Jean-Michel, Laquerriere, Annie, Sevestre, Henri, Lechapt-Zalcman, Emmanuelle, Quintin-Roué, Isabelle, Aubriot-Lorton, Marie-Hélène, Diebold, Marie-Danièle, Viennet, Gabriel, Adam, Clovis, Loussouarn, Delphine, Michalak, Sophie, Rigau, Valérie, Heitzmann, Anne, Vandenbos, Fanny, Forest, Fabien, Chiforeanu, Danchristian, Tortel, Marie-Claire, Labrousse, François, Chenard, Marie-Pierre, Nguyen, Anh Tuan, Varlet, Pascale, Kemeny, Jean Louis, Levillain, Pierre-Marie, Cazals-Hatem, Dominique, Richard, Pomone, and Delattre, Jean-Yves

Published
2015
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36. Supplementary_methods_1 – Supplemental material for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer

Author

Dagher, Elie, Simbault, Laura, Abadie, Jérôme, Loussouarn, Delphine, Campone, Mario, and Nguyen, Frédérique

Subjects
FOS: Clinical medicine, Cell Biology, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_methods_1 for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer by Elie Dagher, Laura Simbault, Jérôme Abadie, Delphine Loussouarn, Mario Campone and Frédérique Nguyen in Tumor Biology

Published
2020
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38. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study

Author

Jézéquel, Pascal, Campion, Loïc, Spyratos, Frédérique, Loussouarn, Delphine, Campone, Mario, Guérin-Charbonnel, Catherine, Joalland, Marie-Pierre, André, Jean, Descotes, Françoise, Grenot, Catherine, Roy, Pascal, Carlioz, Antoine, Martin, Pierre-Marie, Chassevent, Agnès, Jourdan, Marie-Lise, and Ricolleau, Gabriel

Published
2012
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41. Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study

Author

Li, Bryan K., primary, Vasiljevic, Alexandre, additional, Dufour, Christelle, additional, Yao, Fupan, additional, Ho, Ben L. B., additional, Lu, Mei, additional, Hwang, Eugene I., additional, Gururangan, Sridharan, additional, Hansford, Jordan R., additional, Fouladi, Maryam, additional, Nobusawa, Sumihito, additional, Laquerriere, Annie, additional, Delisle, Marie-Bernadette, additional, Fangusaro, Jason, additional, Forest, Fabien, additional, Toledano, Helen, additional, Solano-Paez, Palma, additional, Leary, Sarah, additional, Birks, Diane, additional, Hoffman, Lindsey M., additional, Szathmari, Alexandru, additional, Faure-Conter, Cécile, additional, Fan, Xing, additional, Catchpoole, Daniel, additional, Zhou, Li, additional, Schultz, Kris Ann P., additional, Ichimura, Koichi, additional, Gauchotte, Guillaume, additional, Jabado, Nada, additional, Jones, Chris, additional, Loussouarn, Delphine, additional, Mokhtari, Karima, additional, Rousseau, Audrey, additional, Ziegler, David S., additional, Tanaka, Shinya, additional, Pomeroy, Scott L., additional, Gajjar, Amar, additional, Ramaswamy, Vijay, additional, Hawkins, Cynthia, additional, Grundy, Richard G., additional, Hill, D. Ashley, additional, Bouffet, Eric, additional, Huang, Annie, additional, and Jouvet, Anne, additional

Published
2019
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42. Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo

Author

Joalland, Noémie, Lafrance, Laura, Oullier, Thibauld, Marionneau-Lambot, Severine, Loussouarn, Delphine, Jarry, Ulrich, Scotet, Emmanuel, Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (CRCINA-ÉQUIPE 1), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Cancéropole Nord-Ouest, This study was supported by INSERM, CNRS, Université de Nantes, Association pour la Recherche contre le Cancer (R10139NN), Institut National du Cancer (INCa, PLBio2013-201, PLBio2014-155), Ligue Nationale contre le Cancer (AO InterRegional 2012). This work was realized in the context of the LabEX IGO and the IHU-Cesti programs, supported by the National Research Agency Investissements d’Avenir via the programs ANR-11-LABX-0016-01 and ANR-10-IBHU-005, respectively. The IHU-Cesti project is also supported by Nantes Metropole and the Pays de la Loire Region., Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), and SCOTET, Emmanuel

Subjects
lcsh:Immunologic diseases. Allergy, epithelial ovarian cancer, [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV]Life Sciences [q-bio], Human Vγ9Vδ2 T lymphocytes, zoledronate, [SDV.CAN]Life Sciences [q-bio]/Cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, chemotherapy, lcsh:RC254-282, [SDV] Life Sciences [q-bio], orthotopic xenograft mouse model, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.IMM]Life Sciences [q-bio]/Immunology, immunotherapy, lcsh:RC581-607, Original Research
Abstract

International audience; Epithelial ovarian cancer (EOC) represents 5% of human gynecologic cancers in the world, is hetero- geneous and highly invasive with a dismal prognosis (5 year-survival rate

Published
2019

43. Additional file 18: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

External TNBC cohort’s clinicopathologic characteristics in function of the three clusters (C’1, C’2, and C’3). (PDF 136 kb)

Published
2019
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44. Additional file 29: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Proposed therapeutic strategies in function of GES and robust subtyping results. (PDF 162 kb)

Published
2019
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45. Additional file 5: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Fuzzy clustering of 238 TNBC. Distribution of patients based on probability of belonging to cluster: C1, n = 55 (blue); C2, n = 98 (red) and C3, n = 85 (green). Each vertex of the triangle represents a cluster and each point represents a patient, placed as the barycenter of the triangle, weights being the probabilities of belonging to each of the clusters. The closer a point is to one of the vertices, the greater is the probability of the patient to belong to the corresponding cluster. (PDF 86 kb)

Published
2019
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46. Additional file 3: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Details of antibodies used for immunohistochemistry. (PDF 84 kb)

Published
2019
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47. Additional file 4: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohorts in the first PCA plane. (A) PACS08 patients (n = 131, [orange]) compared to TNBC patients of a previous study (n = 107, [black]). (B) Each color represents a recruitment site, except for grayish pale green color, which represents one or two patients recruited in different sites (n = 36 patients; 28 sites). Total number of recruitment sites was equal to 45. (PDF 95 kb)

Published
2019
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48. Additional file 9: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Categorical GES analyses result in function of internal TNBC clusters (C1, C2, and C3). (PDF 107 kb)

Published
2019
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49. Additional file 6: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Event-free survival analysis of TNBC pooled cohort. This cohort is composed of 427 patients from internal (n = 238) and external (n = 189) cohorts (C1 & C’1 [blue]; C2 & C’2 [red] and C3 & C’3 [green]). (PDF 141 kb)

Published
2019
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50. Additional file 7: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohort in the first PCA plane. (C1, n = 55 [blue]; C2, n = 98 [red]; C3, n = 85 [green]). (PDF 88 kb)

Published
2019
Full Text
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