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Brain function connectivity, derived from functional magnetic resonance imaging (fMRI), has enjoyed high popularity in studies of Autism Spectrum Disorder (ASD) diagnosis. Albeit rapid progress has been made, most studies still suffer from several knotty issues: (1) the hardship of effectively modeling the sophisticated brain neuronal connectivity;(2) the dimensionality explosion resulted from excessive voxels in each fMRI sample; (3) the poor interpretability giving rise to unpersuasive diagnosis. To ameliorate these issues, we propose a GCN-based model, namely ConResNet. Specifically, a convolutional restructuring attention is designed for efficiently ROI-interaction feature extraction. Besides, we embed a salient graph pooling method to sift salient nodes. Extensive experiments conducted on ABIDE dataset demonstrate ConResNet achieves state-of-the-art performance. Moreover, the most salient brain regions predicted by ConResNet are closely consistent with theoretical knowledge in the medical domain, providing potential biomarkers for ASD clinical diagnosis.

Community structure is ubiquitous in various complex networks in nature and is one of the important characteristics of network structure.Community detection can identify useful information in the network,and help to analyze the structure and function of the network.It is widely used in social networks,biology,medicine and other fields.Aiming at the low accuracy of the current community detection algorithm based on local similarity in complex networks,a community detection algorithm based on Markov similarity enhancement and network embedding is proposed.Firstly,inspired by the idea of Markov chain,a Markov similarity enhancement method is proposed,which obtains the steady-state Markov similarity enhancement matrix through the Mar-kov iterative state transition of the initial network.According to the Markov similarity index,the network is divided into initial community structure.Then,a new community similarity index is proposed by combining the network topology and network embedding.The small community in the initial community structure is merged with its closely connected community to obtain the network community structure.On 7 real networks and artificial networks with variable parameters,compared with other 5 well-known community detection algorithms,it is proved that the proposed algorithm has a good community detection effect.

In this study, from the perspective of image processing, we propose the iDNA-ITLM model, using a novel data enhance strategy by continuously self-replicating a short DNA sequence into a longer DNA sequence and then embedding it into a high-dimensional matrix to enlarge the receptive field, for identifying DNA methylation sites. Our model consistently outperforms the current state-of-the-art sequence-based DNA methylation site recognition methods when evaluated on 17 benchmark datasets that cover multiple species and include three DNA methylation modifications (4mC, 5hmC, and 6mA). The experimental results demonstrate the robustness and superior performance of our model across these datasets. In addition, our model can transfer learning to RNA methylation sequences and produce good results without modifying the hyperparameters in the model. The proposed iDNA-ITLM model can be considered a universal predictor across DNA and RNA methylation species. [ABSTRACT FROM AUTHOR]

In recent years, with the application of Internet of Things (IoT) and cloud technology in smart industrialization, Industrial Internet of Things (IIoT) has become an emerging hot topic. The increasing amount of data and device numbers in IIoT poses significant challenges to its security issues, making anomaly detection particularly important. Existing methods for anomaly detection in the IIoT often fall short when dealing with data imbalance, and the huge amount of IIoT data makes feature selection challenging and computationally intensive. In this paper, we propose an optimal deep learning model for anomaly detection in IIoT. Firstly, by setting different thresholds of eXtreme Gradient Boosting (XGBoost) for feature selection, features with importance above the given threshold are retained, while those below are ignored. Different thresholds yield different numbers of features. This approach not only secures effective features but also reduces the feature dimensionality, thereby decreasing the consumption of computational resources. Secondly, an optimized loss function is designed to study its impact on model performance in terms of handling imbalanced data, highly similar categories, and model training. We select the optimal threshold and loss function, which are part of our optimal model, by comparing metrics such as accuracy, precision, recall, False Alarm Rate (FAR), Area Under the Receiver Operating Characteristic Curve (AUC-ROC), and Area Under the Precision–Recall Curve (AUC-PR) values. Finally, combining the optimal threshold and loss function, we propose a model named MIX_LSTM for anomaly detection in IIoT. Experiments are conducted using the UNSW-NB15 and NSL-KDD datasets. The proposed MIX_LSTM model can achieve 0.084 FAR, 0.984 AUC-ROC, and 0.988 AUC-PR values in the binary anomaly detection experiment on the UNSW-NB15 dataset. In the NSL-KDD dataset, it can achieve 0.028 FAR, 0.967 AUC-ROC, and 0.962 AUC-PR values. By comparing the evaluation indicators, the model shows good performance in detecting abnormal attacks in the Industrial Internet of Things compared with traditional deep learning models, machine learning models and existing technologies. [ABSTRACT FROM AUTHOR]

Data categorization is a top concern in medical data to predict and detect illnesses; thus, it is applied in modern healthcare informatics. In modern informatics, machine learning and deep learning models have enjoyed great attention for categorizing medical data and improving illness detection. However, the existing techniques, such as features with high dimensionality, computational complexity, and long-term execution duration, raise fundamental problems. This study presents a novel classification model employing metaheuristic methods to maximize efficient positives on Chronic Kidney Disease diagnosis. The medical data is initially massively pre-processed, where the data is purified with various mechanisms, including missing values resolution, data transformation, and the employment of normalization procedures. The focus of such processes is to leverage the handling of the missing values and prepare the data for deep analysis. We adopt the Binary Grey Wolf Optimization method, a reliable subset selection feature using metaheuristics. This operation is aimed at improving illness prediction accuracy. In the classification step, the model adopts the Extreme Learning Machine with hidden nodes through data optimization to predict the presence of CKD. The complete classifier evaluation employs established measures, including recall, specificity, kappa, F-score, and accuracy, in addition to the feature selection. Data related to the study show that the proposed approach records high levels of accuracy, which is better than the existing models. [ABSTRACT FROM AUTHOR]

With the emergence of blockchain technology, the cryptocurrency market has experienced significant growth in recent years, simultaneously fostering environments conducive to cybercrimes such as phishing scams. Phishing scams on blockchain platforms like Ethereum have become a grave economic threat. Consequently, there is a pressing demand for effective detection mechanisms for these phishing activities to establish a secure financial transaction environment. However, existing methods typically utilize only the most recent transaction record when constructing features, resulting in the loss of vast amounts of transaction data and failing to adequately reflect the characteristics of nodes. Addressing this need, this study introduces a multiscale feature fusion approach integrated with a graph convolutional network model to detect phishing scams on Ethereum. A node basic feature set comprising 12 features is initially designed based on the Ethereum transaction dataset in the basic feature module. Subsequently, in the edge embedding representation module, all transaction times and amounts between two nodes are sorted, and a gate recurrent unit (GRU) neural network is employed to capture the temporal features within this transaction sequence, generating a fixed-length edge embedding representation from variable-length input. In the time trading feature module, attention weights are allocated to all embedding representations surrounding a node, aggregating the edge embedding representations and structural relationships into the node. Finally, combining basic and time trading features of the node, graph convolutional networks (GCNs), SAGEConv, and graph attention networks (GATs) are utilized to classify phishing nodes. The performance of these three graph convolution-based deep learning models is validated on a real Ethereum phishing scam dataset, demonstrating commendable efficiency. Among these, SAGEConv achieves an F1-score of 0.958, an AUC-ROC value of 0.956, and an AUC-PR value of 0.949, outperforming existing methods and baseline models. [ABSTRACT FROM AUTHOR]