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151 results on '"Lin, Mingyan"'

1. Quantum Q-systems and fermionic sums -- the non-simply laced case

Author

Lin, Mingyan Simon

Subjects
Mathematics - Quantum Algebra, Mathematics - Combinatorics, Mathematics - Representation Theory, 17B37, 13F60
Abstract

In this paper, we seek to prove the equality of the $q$-graded fermionic sums conjectured by Hatayama et al. in its full generality, by extending the results of Di Francesco and Kedem to the non-simply laced case. To this end, we will derive explicit expressions for the quantum $Q$-system relations, which are quantum cluster mutations that correspond to the classical $Q$-system relations, and write the identity of the $q$-graded fermionic sums as a constant term identity. As an application, we will show that these quantum $Q$-system relations are consistent with the short exact sequence of the Feigin-Loktev fusion product of Kirillov-Reshetikhin modules obtained by Chari and Venkatesh., Comment: 43 pages. Typographical errors are corrected, and the references are clarified

Published
2019

5. Investigating Properties of a Family of Quantum Renyi Divergences

Author

Lin, Mingyan Simon and Tomamichel, Marco

Subjects
Quantum Physics, Mathematical Physics
Abstract

Audenaert and Datta recently introduced a two-parameter family of relative R\'{e}nyi entropies, known as the $\alpha$-$z$-relative R\'{e}nyi entropies. The definition of the $\alpha$-$z$-relative R\'{e}nyi entropy unifies all previously proposed definitions of the quantum R\'{e}nyi divergence of order $\alpha$ under a common framework. Here we will prove that the $\alpha$-$z$-relative R\'{e}nyi entropies are a proper generalization of the quantum relative entropy by computing the limit of the $\alpha$-$z$ divergence as $\alpha$ approaches one and $z$ is an arbitrary function of $\alpha$. We also show that certain operationally relevant families of R\'enyi divergences are differentiable at $\alpha = 1$. Finally, our analysis reveals that the derivative at $\alpha = 1$ evaluates to half the relative entropy variance, a quantity that has attained operational significance in second-order quantum hypothesis testing., Comment: 15 pages, v2: journal version

Published
2014
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7. DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome

Author

Tang, Xiao-Yan, Xu, Lei, Wang, Jingshen, Hong, Yuan, Wang, Yuanyuan, Zhu, Qian, Wang, Da, Zhang, Xin-Yue, Liu, Chun-Yue, Fang, Kai-Heng, Han, Xiao, Wang, Shihua, Wang, Xin, Xu, Min, Bhattacharyya, Anita, Guo, Xing, Lin, Mingyan, and Liu, Yan

Subjects
Cerebral cortex -- Genetic aspects -- Health aspects, Organs, Culture of -- Usage, Stem cells -- Genetic aspects -- Health aspects, Down syndrome -- Complications and side effects, Brain -- Abnormalities, Neurological research, Protein kinases -- Genetic aspects -- Health aspects, Neurogenesis -- Research, Cell adhesion molecules -- Genetic aspects -- Health aspects, Cellular signal transduction -- Research, Health care industry
Abstract

Down syndrome (DS), caused by trisomy of chromosome 21, occurs in 1 of every 800 live births. Early defects in cortical development likely account for the cognitive impairments in DS, although the underlying molecular mechanism remains elusive. Here, we performed histological assays and unbiased single-cell RNA-Seq (scRNA-Seq) analysis on cerebral organoids derived from 4 euploid cell lines and from induced pluripotent stem cells (iPSCs) from 3 individuals with trisomy 21 to explore cell-type-specific abnormalities associated with DS during early brain development. We found that neurogenesis was significantly affected, given the diminished proliferation and decreased expression of layer II and IV markers in cortical neurons in the subcortical regions; this may have been responsible for the reduced size of the organoids. Furthermore, suppression of the DSCAM/PAK1 pathway, which showed enhanced activity in DS, using CRISPR/Cas9, CRISPR interference (CRISPRi), or small-molecule inhibitor treatment reversed abnormal neurogenesis, thereby increasing the size of organoids derived from DS iPSCs. Our study demonstrates that 3D cortical organoids developed in vitro are a valuable model of DS and provide a direct link between dysregulation of the DSCAM/PAK1 pathway and developmental brain defects in DS., Introduction Down syndrome (DS), caused by trisomy of chromosome 21, is the most frequent genetic cause of birth defects and cognitive abnormalities, with an occurrence of 1 of 800 live [...]

Published
2021
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13. Additional file 5 of Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD

Author

Huang, Qiqing, Wang, Yuanyuan, Zhang, Lili, Qian, Wei, Shen, Shaoran, Wang, Jingshen, Wu, Shuangshuang, Xu, Wei, Chen, Bo, Lin, Mingyan, and Wu, Jianqing

Abstract

Additional file 5: Dataset 3. Lists of markers in 3 sub-clusters of monocytes, namely CD14+ classical monocytes, CD14+ intermediate monocytes, and CD16+ non-classical monocytes, related to Fig. S3B–S3D. The resulting sub-cluster markers were identified by the seurat FindAllMarkers, including the p-value, the average log2(fold change) of the gene in the sub-cluster compared to all other sub-clusters, the percent of cells expressing the gene in the sub-cluster (pct.1), the percent of cells expressing the gene in all other sub-clusters (pct.2), and the adjusted p-value.

Published
2023
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15. RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis

Author

Qian, Baomei, primary, Li, Yang, additional, Yan, Ruoyu, additional, Han, Shenglin, additional, Bu, Zhiwen, additional, Gong, Jie, additional, Zheng, Bangjin, additional, Yuan, Zihan, additional, Ren, Sen, additional, He, Qing, additional, Zhang, Jinwen, additional, Xu, Chen, additional, Wang, Ruilin, additional, Sun, Zheng, additional, Lin, Mingyan, additional, Zhou, Jian, additional, and Ye, Lan, additional

Published
2022
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16. Sexual Reproduction Is Not Responsible for Caragana Shrub Encroachment in Grasslands.

Author

Xie, Lina, Li, Yuchen, Lin, Mingyan, Guo, Hongyu, Wang, Yue, Wang, Lihong, and Ma, Chengcang

Subjects
GRASSLANDS, SHRUBS, ARID regions, FIELD research, GRAZING
Abstract

Shrubs tended to increase their abundance as climatic aridity and grazing intensity increased in the Inner Mongolian grassland. Increasing shrub abundance was believed to be due to enhanced reproduction. However, the effects of climatic aridity and grazing on the sexual reproduction of shrubs in grassland remain largely unclear. In this study, we conducted field experiments with Caragana microphylla to examine the variation of sexual reproduction aspects (seed production, seed vigor, and sapling establishment) along a climatic aridity gradient (subhumid, semiarid, arid, and dry arid zones) and a grazing intensity gradient (fenced, mildly grazed, and severely grazed). We then quantified the population growth rate based on seed production and sapling establishment rates. Our objective was to evaluate whether sexual reproduction is the main mechanism for Caragana encroachment into grasslands. We found that climatic aridity decreased seed quantity and seed vigor but increased the sapling establishment rate of Caragana shrubs. Under ungrazed conditions, climatic aridity did not affect population growth rates, while under grazing conditions, increased aridity stresses reduced population growth rates. Grazing reduced seed production, sapling establishment, and population growth rates. Climatic aridity enhanced the negative effects of grazing on sexual reproduction, while grazing intensified the negative effects of aridity on the population growth of Caragana shrubs. In conclusion, climatic aridity, grazing, and their combined effects had negative effects on the sexual reproduction of Caragana shrubs. Therefore, sexual reproduction could not fully explain the increased abundance of shrubs with increasing aridity and grazing. Clonal reproduction might be of considerable importance for understanding the mechanism of shrub encroachment in grasslands. [ABSTRACT FROM AUTHOR]

Published
2023
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21. HDAC3 controls male fertility through enzyme-independent transcriptional regulation at the meiotic exit of spermatogenesis

Author

Yin, Huiqi, primary, Kang, Zhenlong, additional, Zhang, Yingwen, additional, Gong, Yingyun, additional, Liu, Mengrou, additional, Xue, Yanfeng, additional, He, Wenxiu, additional, Wang, Yanfeng, additional, Zhang, Shuya, additional, Xu, Qiushi, additional, Fu, Kaiqiang, additional, Zheng, Bangjin, additional, Xie, Jie, additional, Zhang, Jinwen, additional, Wang, Yuanyuan, additional, Lin, Mingyan, additional, Zhang, Yihan, additional, Feng, Hua, additional, Xin, Changpeng, additional, Guan, Yichun, additional, Huang, Chaoyang, additional, Guo, Xuejiang, additional, Wang, P Jeremy, additional, Baur, Joseph A, additional, Zheng, Ke, additional, Sun, Zheng, additional, and Ye, Lan, additional

Published
2021
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26. Klotho antagonizes pulmonary fibrosis through suppressing pulmonary fibroblasts activation, migration, and extracellular matrix production: a therapeutic implication for idiopathic pulmonary fibrosis

Author

Huang, Qiqing, primary, Chen, Yan, additional, Shen, Shaoran, additional, Wang, Yuanyuan, additional, Liu, Liya, additional, Wu, Shuangshuang, additional, Xu, Wei, additional, Zhao, Weihong, additional, Lin, Mingyan, additional, and Wu, Jianqing, additional

Published
2020
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28. Another look at the relation between credit spreads and interest rates

Author

Lin, Mingyan and Curtillet, Jean-Christophe

Subjects
Interest rates -- Analysis, Bonds -- Analysis, Correlation (Statistics) -- Analysis, Default (Finance) -- Analysis, Risk assessment -- Analysis, Banking, finance and accounting industries, Business
Abstract

Empirical research until now has mostly documented a significant negative correlation between movements in interest rates and credit spreads (e.g., Cornell and Green [1991]; Fridson and Kenny [1994]; Longstaff and [...]

Published
2007

29. Correction: Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes (doi:10.1242/dev.164855)

Author

Bai, Shun, primary, Fu, Kaiqiang, additional, Yin, Huiqi, additional, Cui, Yiqiang, additional, Yue, Qiuling, additional, Li, Wenbo, additional, Cheng, Le, additional, Tan, Huanhuan, additional, Liu, Xiaofei, additional, Guo, Yueshuai, additional, Zhang, Yingwen, additional, Xie, Jie, additional, He, Wenxiu, additional, Wang, Yuanyuan, additional, Feng, Hua, additional, Xin, Changpeng, additional, Zhang, Jinwen, additional, Lin, Mingyan, additional, Shen, Bin, additional, Sun, Zheng, additional, Guo, Xuejiang, additional, Zheng, Ke, additional, and Ye, Lan, additional

Published
2019
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30. Biological and RNA regulatory function of MOV10 in mammalian germ cells

Author

Fu, Kaiqiang, primary, Tian, Suwen, additional, Tan, Huanhuan, additional, Wang, Caifeng, additional, Wang, Hanben, additional, Wang, Min, additional, Wang, Yuanyuan, additional, Chen, Zhen, additional, Wang, Yanfeng, additional, Yue, Qiuling, additional, Xu, Qiushi, additional, Zhang, Shuya, additional, Li, Haixin, additional, Xie, Jie, additional, Lin, Mingyan, additional, Luo, Mengcheng, additional, Chen, Feng, additional, Ye, Lan, additional, and Zheng, Ke, additional

Published
2019
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32. Quantum Q-Systems and Fermionic Sums—The Non-Simply Laced Case.

Author

Lin, Mingyan Simon

Subjects
*LACE & lace making, *LOGICAL prediction
Abstract

In this paper, we seek to prove the equality of the |$q$| -graded fermionic sums conjectured by Hatayama et al. [ 14 ] in its full generality, by extending the results of Di Francesco and Kedem [ 9 ] to the non-simply laced case. To this end, we will derive explicit expressions for the quantum |$Q$| -system relations, which are quantum cluster mutations that correspond to the classical |$Q$| -system relations, and write the identity of the |$q$| -graded fermionic sums as a constant term identity. As an application, we will show that these quantum |$Q$| -system relations are consistent with the short exact sequence of the Feigin–Loktev fusion product of Kirillov–Reshetikhin modules obtained by Chari and Venkatesh [ 5 ]. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes

Author

Bai, Shun, primary, Fu, Kaiqiang, additional, Yin, Huiqi, additional, Cui, Yiqiang, additional, Yue, Qiuling, additional, Li, Wenbo, additional, Cheng, Le, additional, Tan, Huanhuan, additional, Liu, Xiaofei, additional, Guo, Yueshuai, additional, Zhang, Yingwen, additional, Xie, Jie, additional, He, Wenxiu, additional, Wang, Yuanyuan, additional, Feng, Hua, additional, Xin, Changpeng, additional, Zhang, Jinwen, additional, Lin, Mingyan, additional, Shen, Bin, additional, Sun, Zheng, additional, Guo, Xuejiang, additional, Zheng, Ke, additional, and Ye, Lan, additional

Published
2018
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39. MYOSLID Is a Novel Serum Response Factor–Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation Program

Author

Zhao, Jinjing, primary, Zhang, Wei, additional, Lin, Mingyan, additional, Wu, Wen, additional, Jiang, Pengtao, additional, Tou, Emiley, additional, Xue, Min, additional, Richards, Angelene, additional, Jourd’heuil, David, additional, Asif, Arif, additional, Zheng, Deyou, additional, Singer, Harold A., additional, Miano, Joseph M., additional, and Long, Xiaochun, additional

Published
2016
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45. Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions

Author

UCL - SSS/DDUV - Institut de Duve, Rockowitz, Shira, Lien, Wen-Hui, Pedrosa, Erika, Wei, Gang, Lin, Mingyan, Zhao, Keji, Lachman, Herbert M., Fuchs, Elaine, Zheng, Deyou, UCL - SSS/DDUV - Institut de Duve, Rockowitz, Shira, Lien, Wen-Hui, Pedrosa, Erika, Wei, Gang, Lin, Mingyan, Zhao, Keji, Lachman, Herbert M., Fuchs, Elaine, and Zheng, Deyou

Abstract

Recent studies have shown that the transcriptional functions of REST are much broader than repressing neuronal genes in non-neuronal systems. Whether REST occupies similar chromatin regions in different cell types and how it interacts with other transcriptional regulators to execute its functions in a context-dependent manner has not been adequately investigated. We have applied ChIP-seq analysis to identify the REST cistrome in human CD4+ T cells and compared it with published data from 15 other cell types. We found that REST cistromes were distinct among cell types, with REST binding to several tumor suppressors specifically in cancer cells, whereas 7% of the REST peaks in non-neuronal cells were ubiquitously called and <25% were identified for ≥5 cell types. Nevertheless, using a quantitative metric directly comparing raw ChIP-seq signals, we found the majority (∼80%) was shared by ≥2 cell types. Integration with RNA-seq data showed that REST binding was generally correlated with low gene expression. Close examination revealed that multiple contexts were correlated with reduced expression of REST targets, e.g., the presence of a cognate RE1 motif and cellular specificity of REST binding. These contexts were shown to play a role in differential corepressor recruitment. Furthermore, transcriptional outcome was highly influenced by REST cofactors, e.g., SIN3 and EZH2 co-occupancy marked higher and lower expression of REST targets, respectively. Unexpectedly, the REST cistrome in differentiated neurons exhibited unique features not observed in non-neuronal cells, e.g., the lack of RE1 motifs and an association with active gene expression. Finally, our analysis demonstrated how REST could differentially regulate a transcription network constituted of miRNAs, REST complex and neuronal factors. Overall, our findings of contexts playing critical roles in REST occupancy and regulatory outcome provide insights into the molecular interactions underlying REST's diverse funct

Published
2014

46. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

Author

Lee, William, primary, Teckie, Sewit, additional, Wiesner, Thomas, additional, Ran, Leili, additional, Prieto Granada, Carlos N, additional, Lin, Mingyan, additional, Zhu, Sinan, additional, Cao, Zhen, additional, Liang, Yupu, additional, Sboner, Andrea, additional, Tap, William D, additional, Fletcher, Jonathan A, additional, Huberman, Kety H, additional, Qin, Li-Xuan, additional, Viale, Agnes, additional, Singer, Samuel, additional, Zheng, Deyou, additional, Berger, Michael F, additional, Chen, Yu, additional, Antonescu, Cristina R, additional, and Chi, Ping, additional

Published
2014
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