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Background: In 2016-2017, 68 women in Southern Vietnam had RT-PCR confirmed Zika virus (ZIKV) infection during pregnancy. We report here the outcomes of the pregnancies and the virological analyses related to this outbreak. Methods: We collected clinical and epidemiological information from the women who were enrolled in the study. Medical records related to the pregnancy in 2016–2017 were retrieved for those who were not able to be enrolled in the study. Children born to women with ZIKV infection during pregnancy were also enrolled. Serum samples were evaluated for presence of ZIKV antibodies. Phylogenetic analyses were performed on Zika virus genomes sequenced from the 2016–2017 serum samples. Findings: Of the 68 pregnancies, 58 were livebirths and 10 were medically terminated. Four of the medical records from cases of fetal demise were able to be retrieved, of which one was consistent with congenital ZIKV infection. Of the 58 women with a livebirth, 21 participated in the follow-up investigation. All but two women had serologic evidence of ZIKV infection. Of the 21 children included in the study (mean age: 30.3 months), 3 had microcephaly at birth. No other clinical abnormalities were reported and no differences in neurodevelopment were observed compared to a control group. Phylogenetic analysis revealed a clade within the ZIKV Asian lineage and branch at the root of samples from the 2013–2014 French Polynesian outbreak. The prM S139N mutation was not observed. Interpretation: We have been able to demonstrate a clade within the ZIKV Asian lineage implicated in adverse pregnancy outcomes in Southern Vietnam. Funding: INCEPTION project (PIA/ANR-16-CONV-0005) and a grant received from BNP Paribas Simplidon.

Background: Dengue has spread rapidly in all regions during recent years and the epidemiological features of the disease have changed considerably despite many advances in epidemic prevention. Children and young adults have been the populations most at risk of dengue fever and severe complications. Objectives: Evaluate epidemiological characteristics and the severity of dengue among children in the 2017 dengue outbreak. Results: A review of 1446 paediatric cases with dengue in 2017 showed that male occupied predominantly for 56.9% of the total patients. Patients ≤ 1 year old, 2-5 years old, 6-12 years old and 13-18 years old accounted for 5.2%, 13.8%, 36.6% and 44.4% of the study sample, respectively. The major age group at the Children's Hospital 1 was from 6-12 years old (44.4%) while at the National Hospital for Tropical Diseases, it was from 13-18 years old (61.6%). Dengue outbreak happens widely across Vietnam. In the Southern region, dengue occurs all year round and peaks in the rainy season from June to October, after that, the infection decreases at the end of the year but still maintaining until the beginning of next year. In comparison, dengue transmission in the Northern region had suddenly increased since June 2017, then hit a peak in August 2017 and declined in the remaining months until the end of the year. Speciality, the infection is highly endemic in the Southwest region. It also expanded to the Southeast provinces such as Dong Nai and Binh Duong where emerging industrial zones located. The number of patients with dengue fever in Hanoi in 2017 was not only the greatest in the Northern region but also in the whole country. Comorbidities reported in children were rare with the most frequent diseases being respiratory diseases, gastroenteritis or infections. The incidence of dengue fever, dengue haemorrhagic fever and dengue shock syndrome made up 42%, 35.5% and 22.4%, respectively. Conclusions: Our findings potentially develop a strategy for early detection, prognosis and proactive prevention of dengue in order to reduce the number of cases as well as the fatality rates. [ABSTRACT FROM AUTHOR]