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Your search keyword '"Lieb, Michele"' showing total 11 results
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11 results on '"Lieb, Michele"'

7. Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains

Author

Hemar, Agnes, Subtil, Agathe, Lieb, Michele, Morelon, Emmanuel, Hellio, Raymond, and Dautry-Varsat, Alice

Subjects
Interleukin-2 -- Receptors, T cells -- Physiological aspects, Biological sciences
Abstract

Analysis of the intracellular pathway followed by the interleukin-receptor complex in a human T lymphocytic cell line shows that the receptor subunits end up in different cellular compartments. Following endocytosis of the complex, the alpha subunit is present in the early endocytic compartment while the beta and gamma subunits are present in the late endocytic compartment. The beta and gamma subunits have a half-life of 1 hour and are degraded whereas the alpha subunit has a half-life of 48 hours and is recycled to the plasma membrane.

Published
1995

8. Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold

Author

Martinez, Claudio, Lieb, Michele, Rodriguez-Barrios, Fatima, Alvarez, Rosana, Khanwalkar, H., Gronemeyer, Hinrich, and de Lera, Angel R.

Subjects
organic chemicals, embryonic structures
Abstract

Arotinoids containing a C5,C8-diphenylnaphthalene-2-yl ring linked to a (C3-halogenated) benzoic acid via an ethenyl connector (but not the corresponding naphthamides), which are prepared by Horner-Wadsworth-Emmons reaction of naphthaldehydes and benzylphosphonates, display the rather unusual property of being RXR agonists (15-fold induction of the RXR reporter cell line was achieved at 3- to 10-fold lower concentration than 9-cis-retinoic acid) and RAR antagonists as shown by transient transactivation studies. The binding of such bulky ligands suggests that the RXR ligand-binding domain is endowed with some degree of structural elasticity.

Published
2014

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