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Your search keyword '"Li, Yanlei"' showing total 780 results
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780 results on '"Li, Yanlei"'

11. Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer

Author

Kang Yao, Zhu Xiaojun, Zhao Tingxiao, Liao Shiyao, Ji Lichen, Zhang Wei, Li Yanlei, Tian Jinlong, Ding Xiaoyan, Zhang Jun, Bi Qing, and Lv Jun

Subjects
Breast cancer, Bone metastasis, Prognosis, CAFs, MMP13, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Breast cancer (BC) patients tend to suffer from distant metastasis, especially bone metastasis. Methods All the analysis based on open-accessed data was performed in R software, dependent on multiple algorithms and packages. The RNA levels of specific genes were detected using quantitative Real-time PCR as a method of detecting the RNA levels. To assess the ability of BC cells to proliferate, we utilized the CCK8 test, colony formation, and the 5-Ethynyl-20-deoxyuridine assay. BC cells were evaluated for invasion and migration by using Transwell assays and wound healing assays. Results In our study, we identified the molecules involved in BC bone metastasis based on the data from multiple BC cohorts. Then, we comprehensively investigated the effect pattern and underlying biological role of these molecules. We found that in the identified molecules, the EMP1, ACKR3, ITGA10, MMP13, COL11A1, and THY1 were significantly correlated with patient prognosis and mainly expressed in CAFs. Therefore, we explored the CAFs in the BC microenvironment. Results showed that CAFs could activate multiple carcinogenic pathways and most of these pathways play an important role in cancer metastasis. Meanwhile, we noticed the interaction between CAFs and malignant, endothelial, and M2 macrophage cells. Moreover, we found that CAFs could induce the remodeling of the BC microenvironment and promote the malignant behavior of BC cells. Then, we identified MMP13 for further analysis. It was found that MMP13 can enhance the malignant phenotype of BC cells. Meanwhile, biological enrichment and immune infiltration analysis were conducted to present the effect pattern of MMP13 in BC. Conclusions Our result can improve the understanding of researchers on the underlying mechanisms of BC bone metastasis.

Published
2023
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18. Mesh Total Generalized Variation for Denoising

Author

Liu, Zheng, Li, YanLei, Wang, Weina, Liu, Ligang, and Chen, Renjie

Subjects
Computer Science - Computational Geometry, Computer Science - Graphics
Abstract

Total Generalized Variation (TGV) has recently been proven certainly successful in image processing for preserving sharp features as well as smooth transition variations. However, none of the existing works aims at numerically calculating TGV over triangular meshes. In this paper, we develop a novel numerical framework to discretize the second-order TGV over triangular meshes. Further, we propose a TGV-based variational model to restore the face normal field for mesh denoising. The TGV regularization in the proposed model is represented by a combination of a first- and second-order term, which can be automatically balanced. This TGV regularization is able to locate sharp features and preserve them via the first-order term, while recognize smoothly curved regions and recover them via the second-order term. To solve the optimization problem, we introduce an efficient iterative algorithm based on variable-splitting and augmented Lagrangian method. Extensive results and comparisons on synthetic and real scanning data validate that the proposed method outperforms the state-of-the-art methods visually and numerically.

Published
2021

39. Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis

Author

Li, Yanlei, primary, Deng, Huixiong, additional, Zhang, Hengyao, additional, Yang, Lin, additional, Wang, Shenmiao, additional, Wang, Haoyang, additional, Zhu, Jiacheng, additional, Li, Xiaoning, additional, Chen, Xiaoxuan, additional, Lin, Yinhong, additional, Li, Rui, additional, Wang, Gefei, additional, and Li, Kangsheng, additional

Published
2024
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