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371 results on '"Lee, Pei-Lin"'

1. Recommended assessment and management of sleep disordered breathing in patients with atrial fibrillation, hypertension and heart failure: Taiwan Society of Cardiology/Taiwan Society of sleep Medicine/Taiwan Society of pulmonary and Critical Care Medicine joint consensus statement

Author

Lee, Pei-Lin, Wu, Yen-Wen, Cheng, Hao-Min, Wang, Cheng-Yi, Chuang, Li-Pang, Lin, Chou-Han, Hang, Liang-Wen, Yu, Chih-Chieh, Hung, Chung-Lieh, Liu, Ching-Lung, Chou, Kun-Ta, Su, Mao-Chang, Cheng, Kai-Hung, Huang, Chun-Yao, Hou, Charles Jia-Yin, and Chiu, Kuo-Liang

Published
2024
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11. Computational fluid dynamics study in children with obstructive sleep apnea.

Author

Hsu, Wei‐Chung, Kang, Kun‐Tai, Chen, Yunn‐Jy, Weng, Wen‐Chin, Lee, Pei‐Lin, and Hsiao, Hung‐Ta

Subjects
COMPUTATIONAL fluid dynamics, SLEEP apnea syndromes, CONE beam computed tomography, AIRWAY resistance (Respiration), BODY mass index
Abstract

Objectives: This study aims to identify characteristics in image‐based computational fluid dynamics (CFD) in children with obstructive sleep apnea (OSA). Design: Diagnostic study. Setting: Hospital‐based cohort. Participants: Children with symptoms suggestive of OSA were recruited and underwent polysomnography. Main outcome measures: Three‐dimensional models of computational fluid dynamics were derived from cone‐beam computed tomography. Results: A total of 68 children participated in the study (44 boys; mean age: 7.8 years), including 34 participants having moderate‐to‐severe OSA (apnea‐hypopnea index [AHI] greater than 5 events/h), and 34 age, gender, and body mass index percentile matched participants having primary snoring (AHI less than 1). Children with moderate‐to‐severe OSA had a significantly higher total airway pressure (166.3 vs. 39.1 Pa, p =.009), total airway resistance (9851 vs. 2060 Newton‐metre, p =.004) and velocity at a minimal cross‐sectional area (65.7 vs. 8.8 metre per second, p =.017) than those with primary snoring. The optimal cut‐off points for moderate‐to‐severe OSA were 46.2 Pa in the total airway pressure (area under the curve [AUC] = 73.2%), 2373 Newton‐metre in the total airway resistance (AUC = 72.5%) and 12.6 metres per second in the velocity at a minimal cross‐sectional area (AUC = 70.5%). The conditional logistic regression model revealed that total airway pressure, total airway resistance and velocity at minimal cross‐sectional area were significantly associated with an increased risk of moderate‐to‐severe OSA. Conclusions: This study demonstrates that CFD could be a useful tool for evaluating upper airway patency in children with OSA. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Recommended assessment and management of sleep disordered breathing in patients with atrial fibrillation, hypertension and heart failure: Taiwan Society of Cardiology/Taiwan Society of sleep Medicine/Taiwan Society of pulmonary and Critical Care Medicine joint consensus statement

Author

Lee, Pei-Lin, primary, Wu, Yen-Wen, additional, Cheng, Hao-Min, additional, Wang, Cheng-Yi, additional, Chuang, Li-Pang, additional, Lin, Chou-Han, additional, Hang, Liang-Wen, additional, Yu, Chih-Chieh, additional, Hung, Chung-Lieh, additional, Liu, Ching-Lung, additional, Chou, Kun-Ta, additional, Su, Mao-Chang, additional, Cheng, Kai-Hung, additional, Huang, Chun-Yao, additional, Hou, Charles Jia-Yin, additional, and Chiu, Kuo-Liang, additional

Published
2023
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16. 0484 The association between obstructive sleep apnea, energy balance and body composition: a clinical cohort

Author

Lee, Pei-Lin, primary, Lai, Shang-Ru, additional, Gooley, Joshua, additional, Feng, Hsin-Chun, additional, Chen, Shih-Kuo, additional, Chien, Meng-Yueh, additional, Lin, Ming-Tzer, additional, Chen, Yung-Hsuan, additional, Chiu, Hung-Chih, additional, Liu, Po-Kang, additional, Ku, Bo-Wen, additional, Chang, Chin-Hao, additional, Yang, Wei-Shiung, additional, and Yu, Chong-Jen, additional

Published
2023
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30. Obstructive sleep apnea and its management in patients with atrial fibrillation: An International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT) global survey of practicing cardiologists

Author

Faulx, Michael D., primary, Mehra, Reena, additional, Reis Geovanini, Glaucylara, additional, Ando, Shin-ichi, additional, Arzt, Michael, additional, Drager, Luciano, additional, Fu, Michael, additional, Hoyos, Camilla, additional, Hai, Jo, additional, Hwang, Juey-Jen, additional, Karaoguz, Remzi, additional, Kimoff, John, additional, Lee, Pei-Lin, additional, Mediano, Olga, additional, Patel, Sanjay R., additional, Peker, Yüksel, additional, Louis Pepin, Jean, additional, Sanchez-de-la-Torre, Manuel, additional, Sériès, Frédéric, additional, Stadler, Stefan, additional, Strollo, Patrick, additional, Tahrani, A.A., additional, Thunström, Erik, additional, Yamauchi, Motoo, additional, Redline, Susan, additional, and Phillips, Craig L., additional

Published
2022
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36. Objective and subjective measures of sleep in men with Muscular Dystrophy

Author

Lee, Pei-Lin, Morse, Christopher I, Onambele-Pearson, Gladys, Edwards, Bryn, Wong, Sze Choong, Jacques, Matthew F, Lee, Pei-Lin, Morse, Christopher I, Onambele-Pearson, Gladys, Edwards, Bryn, Wong, Sze Choong, and Jacques, Matthew F

Abstract

Purpose Despite poor sleep quality being recognised in Duchenne Muscular Dystrophy, reports from milder forms of Muscular Dystrophy (MD), and accompanied associations with quality of life (QoL), pain and fatigue, remain limited however. Methods Adult males (n = 15 Beckers MD (BMD), n = 12 Limb-Girdle MD (LGMD), n = 12 Fascioscapulohumeral (FSHD), n = 14 non-MD (CTRL)) completed assessments of body composition (Bio-electrical impedance), sleep (7-day 24-hour tri-axial accelerometer, Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index, QoL (SF36-v2), pain (Visual analogue scale), fatigue (Modified Fatigue Index Scale) and functional assessments (Brookes and Vignos). Results FSHD and BMD reported worse sleep than CTRL on the PSQI. FSHD scored worse than CTRL on the Insomnia Severity Index (P<0.05). 25–63% and 50–81% of adults with MD reported poor sleep quality using the Insomnia Severity Index and PSQI, respectively. Accelerometery identified no difference in sleep quality between groups. Associations were identified between sleep measures (PSQI global and insomnia severity) with mental or physical QoL in LGMD, BMD and FSHD. Multiple regression identified associations between sleep impairment and fatigue severity (all MDs), body composition (BMD & LGMD), upper and lower limb function (LGMD, FSHD) and age (FSHD). Conclusions 25–81% of men with MD, depending on classification, experience sleep impairment, using self-report sleep measures. Whilst BMD and FSHD showed worse sleep outcomes than CTRL, no group difference was observed between LGMD and CTRL, however all groups showed associations with sleep impairment and higher levels of fatigue. These findings, and associations with measures of health and wellbeing, highlight an area for further research which could impact QoL in adults with MD.

Published
2022

37. Prediction of Mandibular Advancement Device Response Using CPAP Pressure in Different Polysomnographic Phenotypes

Author

Lee,Chien-Feng, Chen,Yunn-Jy, Huang,Wen-Chi, Hou,Jen-Wen, Liu,Yu-Ting, Shih,Tiffany Ting-Fang, Lee,Pei-Lin, Yu,Chong-Jen, Lee,Chien-Feng, Chen,Yunn-Jy, Huang,Wen-Chi, Hou,Jen-Wen, Liu,Yu-Ting, Shih,Tiffany Ting-Fang, Lee,Pei-Lin, and Yu,Chong-Jen

Abstract

Chien-Feng Lee,1,* Yunn-Jy Chen,2,* Wen-Chi Huang,3 Jen-Wen Hou,4 Yu-Ting Liu,5 Tiffany Ting-Fang Shih,6 Pei-Lin Lee,7– 10 Chong-Jen Yu1,8,9 1Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan; 2Department of Dentistry, School of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan; 4Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan; 5MediaTek Inc., Hsinchu, Taiwan; 6Department of Radiology and Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; 7Center of Sleep Disorder, National Taiwan University Hospital, Taipei, Taiwan; 8Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 9School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; 10Center for Electronics Technology Integration, National Taiwan University, Taipei, Taiwan*These authors contributed equally to this workCorrespondence: Pei-Lin Lee, Tel +886-2-2356-2755, Fax +886-2-2358-2867, Email leepeilin@ntu.edu.twObjective: Both continuous positive airway pressure (CPAP) pressure and polysomnographic phenotypes have been associated with mandibular advancement device (MAD) treatment response, but the precise relationship has not been fully elucidated. We hypothesized that utilizing CPAP pressure would predict the MAD response in treatment-naïve patients with moderate-severe obstructive sleep apnea (OSA), and the MAD response would be associated with two polysomnographic phenotypes, including sleep stage dependency and positional dependency.Methods: OSA treatment-naïve patients with an apnea-hypopnea index (AHI) ≥ 15/h who declined CPAP treatment and received MAD treatment for 3– 6 months were enrolled. The MAD treatment response was defined as 1) residual AHI under MAD (AHIMAD) < 5

Published
2022

42. Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis.

Author

Shih, Yu-Tsung, Wei, Shu-Yi, Chen, Jin-Hua, Wang, Wei-Li, Wu, Hsin-Yi, Wang, Mei-Cun, Lin, Chia-Yu, Lee, Pei-Lin, Lin, Chih-Yuan, Chiang, Hung-Che, Chen, Yu-Ju, Chien, Shu, and Chiu, Jeng-Jiann

Subjects
VINCULIN, PULSATILE flow, ATHEROSCLEROSIS, VASCULAR endothelium, CORONARY artery disease, ATHEROSCLEROTIC plaque, ENDOTHELIUM diseases
Abstract

Background and aims Atherosclerosis preferentially develops in arterial branches and curvatures where vascular endothelium is exposed to disturbed flow. In this study, the effects of disturbed flow on the regulation of vascular endothelial phosphoproteins and their contribution to therapeutic application in atherogenesis were elucidated. Methods Porcine models, large-scale phosphoproteomics, transgenic mice, and clinical specimens were used to discover novel site-specific phosphorylation alterations induced by disturbed flow in endothelial cells (ECs). Results A large-scale phosphoproteomics analysis of native endothelium from disturbed (athero-susceptible) vs. pulsatile flow (athero-resistant) regions of porcine aortas led to the identification of a novel atherosclerosis-related phosphoprotein vinculin (VCL) with disturbed flow-induced phosphorylation at serine 721 (VCLS721p). The induction of VCLS721p was mediated by G-protein-coupled receptor kinase 2 (GRK2)S29p and resulted in an inactive form of VCL with a closed conformation, leading to the VE-cadherin/catenin complex disruption to enhance endothelial permeability and atherogenesis. The generation of novel apolipoprotein E-deficient (ApoE−/−) mice overexpressing S721-non-phosphorylatable VCL mutant in ECs confirmed the critical role of VCLS721p in promoting atherosclerosis. The administration of a GRK2 inhibitor to ApoE−/− mice suppressed plaque formation by inhibiting endothelial VCLS721p. Studies on clinical specimens from patients with coronary artery disease (CAD) revealed that endothelial VCLS721p is a critical clinicopathological biomarker for atherosclerosis progression and that serum VCLS721p level is a promising biomarker for CAD diagnosis. Conclusions The findings of this study indicate that endothelial VCLS721p is a valuable hemodynamic-based target for clinical assessment and treatment of vascular disorders resulting from atherosclerosis. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Obstructive Sleep Apnea and its Management in Patients with Atrial Fibrillation:&nbsp;An International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT)) Global Survey of Practicing Cardiologists

Author

Faulx, Michael, primary, Mehra, Reena, additional, Geovanini, Glaucylara Reis, additional, Ando, Shin-ichi, additional, Arzt, Michael, additional, Drager, Luciano, additional, Fu, Michael, additional, Hoyos, Camilla M., additional, Hai, Jo, additional, Hwang, Juey-Jen, additional, Karaoguz, Remzi, additional, Kimoff, John, additional, Lee, Pei-Lin, additional, Mediano, Olga, additional, Patel, Sanjay, additional, Peker, Yuksel, additional, Pepin, Jean-Louis, additional, Sanchez-de-la-Torre, Manuel, additional, Series, Frederic, additional, Stadler, Stefan, additional, Strollo, Patrick, additional, Tahrani, Abd A., additional, Thunstrom, Erik, additional, Yamauchi, Motoo, additional, Redline, Susan, additional, and Phillips, Craig L., additional

Published
2022
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