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611 results on '"Lazcano, Antonio"'

2. Two short low complexity regions (LCRs) are hallmark sequences of the Delta SARS-CoV-2 variant spike protein

Author

Becerra, Arturo, Muñoz-Velasco, Israel, Aguilar-Cámara, Abelardo, Cottom-Salas, Wolfgang, Cruz-González, Adrián, Vázquez-Salazar, Alberto, Hernández-Morales, Ricardo, Jácome, Rodrigo, Campillo-Balderas, José Alberto, and Lazcano, Antonio

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Biodefense, Emerging Infectious Diseases, Vaccine Related, Prevention, Aetiology, 2.1 Biological and endogenous factors, Amino Acid Substitution, COVID-19, Humans, Mutation, Missense, Proteome, SARS-CoV-2, Spike Glycoprotein, Coronavirus
Abstract

Low complexity regions (LCRs) are protein sequences formed by a set of compositionally biased residues. LCRs are extremely abundant in cellular proteins and have also been reported in viruses, where they may partake in evasion of the host immune system. Analyses of 28,231 SARS-CoV-2 whole proteomes and of 261,051 spike protein sequences revealed the presence of four extremely conserved LCRs in the spike protein of several SARS-CoV-2 variants. With the exception of Iota, where it is absent, the Spike LCR-1 is present in the signal peptide of 80.57% of the Delta variant sequences, and in other variants of concern and interest. The Spike LCR-2 is highly prevalent (79.87%) in Iota. Two distinctive LCRs are present in the Delta spike protein. The Delta Spike LCR-3 is present in 99.19% of the analyzed sequences, and the Delta Spike LCR-4 in 98.3% of the same set of proteins. These two LCRs are located in the furin cleavage site and HR1 domain, respectively, and may be considered hallmark traits of the Delta variant. The presence of the medically-important point mutations P681R and D950N in these LCRs, combined with the ubiquity of these regions in the highly contagious Delta variant opens the possibility that they may play a role in its rapid spread.

Published
2022

3. Primordial Soup

Author

Lazcano, Antonio, Gargaud, Muriel, editor, Irvine, William M., editor, Amils, Ricardo, editor, Claeys, Philippe, editor, Cleaves, Henderson James, editor, Gerin, Maryvonne, editor, Rouan, Daniel, editor, Spohn, Tilman, editor, Tirard, Stéphane, editor, and Viso, Michel, editor

Published
2023
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4. Origin of Life

Author

Lazcano, Antonio, Gargaud, Muriel, editor, Irvine, William M., editor, Amils, Ricardo, editor, Claeys, Philippe, editor, Cleaves, Henderson James, editor, Gerin, Maryvonne, editor, Rouan, Daniel, editor, Spohn, Tilman, editor, Tirard, Stéphane, editor, and Viso, Michel, editor

Published
2023
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5. Structural analysis of viral ExoN domains reveals polyphyletic hijacking events

Author

Cruz-González, Adrián, Muñoz-Velasco, Israel, Cottom-Salas, Wolfgang, Becerra, Arturo, Campillo-Balderas, José A, Hernández-Morales, Ricardo, Vázquez-Salazar, Alberto, Jácome, Rodrigo, and Lazcano, Antonio

Subjects
Biochemistry and Cell Biology, Bioinformatics and Computational Biology, Biological Sciences, Genetics, Prevention, Biodefense, Vaccine Related, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Infection, Amino Acid Sequence, Arenavirus, COVID-19, Exonucleases, Humans, Immunity, Innate, Nidovirales, Protein Domains, RNA Viruses, RNA, Viral, RNA-Dependent RNA Polymerase, SARS-CoV-2, Viral Proteins, Zinc Fingers, General Science & Technology
Abstract

Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5' exonuclease domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the growth of nidoviral genomes, while in arenaviruses this domain partakes in the suppression of the host innate immune signaling. Sequence and structural homology analyses suggest that these proteins have been hijacked from cellular hosts many times. Analysis of the available nidoviral ExoN sequences reveals a high conservation level comparable to that of the viral RNA-dependent RNA polymerases (RdRp), which are the most conserved viral proteins. Two highly preserved zinc fingers are present in all nidoviral exonucleases, while in the arenaviral protein only one zinc finger can be identified. This is in sharp contrast with the reported lack of zinc fingers in cellular ExoNs, and opens the possibility of therapeutic strategies in the struggle against COVID-19.

Published
2021

14. Charles Darwin and the Origin of Life

Author

Peretó, Juli, Bada, Jeffrey L., and Lazcano, Antonio

Subjects
Life Sciences, Biochemistry, general, Astronomy, Observations and Techniques, Earth Sciences, general, Astrophysics and Astroparticles, Life Sciences, general, Darwin, Warm little pond, Origin of life, Spontaneous generation
Abstract

When Charles Darwin published The Origin of Species 150 years ago he consciously avoided discussing the origin of life. However, analysis of some other texts written by Darwin, and of the correspondence he exchanged with friends and colleagues demonstrates that he took for granted the possibility of a natural emergence of the first life forms. As shown by notes from the pages he excised from his private notebooks, as early as 1837 Darwin was convinced that “the intimate relation of Life with laws of chemical combination, & the universality of latter render spontaneous generation not improbable”. Like many of his contemporaries, Darwin rejected the idea that putrefaction of preexisting organic compounds could lead to the appearance of organisms. Although he favored the possibility that life could appear by natural processes from simple inorganic compounds, his reluctance to discuss the issue resulted from his recognition that at the time it was possible to undertake the experimental study of the emergence of life.

Published
2009

17. PLASMOGENY, A NEW SCIENCE OF THE ORIGIN OF LIFE

Author

Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, Silva, Ervin, Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, and Silva, Ervin

Published
2014
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18. CONCEPTS IN BIOLOGY

Author

Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, Silva, Ervin, Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, and Silva, Ervin

Published
2014
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19. Introduction

Author

Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, Silva, Ervin, Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, and Silva, Ervin

Published
2014
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20. Plasmogeny

Author

Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, Silva, Ervin, Cleaves, Henderson James, Lazcano, Antonio, Ledesma Mateos, Ismael, Negrón-Mendoza, Alicia, Peretó, Juli, and Silva, Ervin

Published
2014
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24. Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico

Author

Castelán-Sánchez, Hugo G, primary, Delaye, Luis, primary, Inward, Rhys PD, primary, Dellicour, Simon, primary, Gutierrez, Bernardo, primary, Martinez de la Vina, Natalia, additional, Boukadida, Celia, additional, Pybus, Oliver G, additional, de Anda Jáuregui, Guillermo, additional, Guzmán, Plinio, additional, Flores-Garrido, Marisol, additional, Fontanelli, Óscar, additional, Hernández Rosales, Maribel, additional, Meneses, Amilcar, additional, Olmedo-Alvarez, Gabriela, additional, Herrera-Estrella, Alfredo Heriberto, additional, Sánchez-Flores, Alejandro, additional, Muñoz-Medina, José Esteban, additional, Comas-García, Andreu, additional, Gómez-Gil, Bruno, additional, Zárate, Selene, additional, Taboada, Blanca, additional, López, Susana, additional, Arias, Carlos F, additional, Kraemer, Moritz UG, additional, Lazcano, Antonio, additional, and Escalera Zamudio, Marina, additional

Published
2023
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25. Primordial Soup

Author

Lazcano, Antonio, Gargaud, Muriel, editor, Irvine, William M., editor, Amils, Ricardo, editor, Cleaves, Henderson James (Jim), II, editor, Pinti, Daniele L., editor, Quintanilla, José Cernicharo, editor, Rouan, Daniel, editor, Spohn, Tilman, editor, Tirard, Stéphane, editor, and Viso, Michel, editor

Published
2015
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26. Origin of Life

Author

Lazcano, Antonio, Gargaud, Muriel, editor, Irvine, William M., editor, Amils, Ricardo, editor, Cleaves, Henderson James (Jim), II, editor, Pinti, Daniele L., editor, Quintanilla, José Cernicharo, editor, Rouan, Daniel, editor, Spohn, Tilman, editor, Tirard, Stéphane, editor, and Viso, Michel, editor

Published
2015
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28. Future Perspectives and Strategies in Astrobiology

Author

Ehrenfreund, Pascale, Irvine, Bill, Owen, Toby, Becker, Luann, Blank, Jennifer, Brucato, John, Colangeli, Luigi, Derenne, Sylvie, Dutrey, Anne, Despois, Didier, Lazcano, Antonio, Robert, Francois, Appenzeller, I., Bahcall, J. N., Bertola, F., Cassinelli, J. P., Cesarsky, C. J., Engvold, O., McCray, R., Murdin, P. G., Pacini, F., Radhakrishnan, V., Sato, K., Shu, F. H., Somov, B. V., Sunyaev, R. A., Tanaka, Y., Tremaine, S., Weiss, N. O., Burton, W.B., editor, Kuijpers, J. M. E., editor, van den Heuvel, E. P. J., editor, van Der Laan, H., editor, Ehrenfreund, Pascale, editor, Irvine, William, editor, Owen, Toby, editor, Becker, Luann, editor, Blank, Jen, editor, Brucato, John, editor, Colangeli, Luigi, editor, Derenne, Sylvie, editor, Dutrey, Anne, editor, Despois, Didier, editor, Lazcano, Antonio, editor, and Robert, Francois, editor

Published
2005
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33. Primordial Soup

Author

Lazcano, Antonio, Gargaud, Muriel, editor, Amils, Ricardo, editor, Quintanilla, José Cernicharo, editor, Cleaves, Henderson James (Jim), II, editor, Irvine, William M., editor, Pinti, Daniele L., editor, and Viso, Michel, editor

Published
2011
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34. Origin of Life

Author

Lazcano, Antonio, Gargaud, Muriel, editor, Amils, Ricardo, editor, Quintanilla, José Cernicharo, editor, Cleaves, Henderson James (Jim), II, editor, Irvine, William M., editor, Pinti, Daniele L., editor, and Viso, Michel, editor

Published
2011
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35. Author response: Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico

Author

Castelán-Sánchez, Hugo G, primary, Delaye, Luis, primary, Inward, Rhys PD, primary, Dellicour, Simon, primary, Gutierrez, Bernardo, primary, Martinez de la Vina, Natalia, additional, Boukadida, Celia, additional, Pybus, Oliver G, additional, de Anda Jáuregui, Guillermo, additional, Guzmán, Plinio, additional, Flores-Garrido, Marisol, additional, Fontanelli, Óscar, additional, Hernández Rosales, Maribel, additional, Meneses, Amilcar, additional, Olmedo-Alvarez, Gabriela, additional, Herrera-Estrella, Alfredo Heriberto, additional, Sánchez-Flores, Alejandro, additional, Muñoz-Medina, José Esteban, additional, Comas-García, Andreu, additional, Gómez-Gil, Bruno, additional, Zárate, Selene, additional, Taboada, Blanca, additional, López, Susana, additional, Arias, Carlos F, additional, Kraemer, Moritz UG, additional, Lazcano, Antonio, additional, and Escalera Zamudio, Marina, additional

Published
2023
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36. Discussing the Origin of Life

Author

Borgeson, Warren, Matlin, Nathaniel A., Wächtershäuser, Günter, Lazcano, Antonio, and Bada, Jeffrey L.

Published
2002

39. Prebiotic Chemistry — Biochemistry — Emergence of Life (4.4-2 Ga)

Author

Pascal, Robert, Boiteau, Laurent, Forterre, Patrick, Gargaud, Muriel, Lazcano, Antonio, López-García, Purificación, Moreira, David, Maurel, Marie-Christine, Peretó, Juli, Prieur, Daniel, Reisse, Jacques, Gargaud, Muriel, editor, Claeys, Philippe, editor, López-García, Purificación, editor, Martin, Hervé, editor, Montmerle, Thierry, editor, Pascal, Robert, editor, and Reisse, Jacques, editor

Published
2006
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50. Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico

Author

Castelán-Sánchez, Hugo, primary, Delaye, Luis, additional, Inward, Rhys, additional, Dellicour, Simon, additional, Gutierrez, Bernardo, additional, Vina, Natalia Martinez de la, additional, Pybus, Oliver, additional, de Anda-Jáuregui, Guillermo, additional, Guzmán, Plinio, additional, Flores-Garrido, Marisol, additional, Fontanelli, Óscar, additional, Hernández-Rosales, Maribel, additional, Meneses, Amilcar, additional, Herrera-Estrella, Alfredo, additional, Olmedo-Alvarez, Gabriela, additional, Boukadida, Celia, additional, Sanchez-Flores, Alejandro, additional, Muñoz-Medina, José Esteban, additional, Comas-García, Andreu, additional, Gómez-Gil, Bruno, additional, Zárate, Selene, additional, Taboada, Blanca, additional, López, Susana, additional, Arias, Carlos, additional, Kraemer, Moritz, additional, Lazcano, Antonio, additional, and Escalera-Zamudio, Marina, additional

Published
2022
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