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This dissertation illuminates students’ experiences of “soul healing” through the cultivation of spirituality, self-love/ self-knowledge, mentorship, and community in the context of two UCLA courses: the Music and Dance of Ghana World Music Performance Ensemble, taught by master drummer Kobla Ladzekpo of the Anlo-Ewe ethnic group in Ghana, West Africa, and “Advanced Hip Hop,” taught by “street dance” pioneer and choreographer Rennie Harris, of Philadelphia, PA. My definition of soul healing is inspired by historian Bernice Johnson Reagon’s conviction that many African American music traditions were conceived and carried out for the purpose of treating the wounds left by “soul murder,” a phenomenon that historian Nell Irvin Painter characterizes as the collective trauma that resulted from the trans-Atlantic slave trade and its aftermath. Drawing upon philosopher Arnold Van Gennep’s theory of rites of passage and anthropologist Victor Turner’s ensuing conceptualization of liminality, I conclude that the courses explored in this dissertation create the circumstance for a transitioning into adulthood that empowers students to healthfully matriculate through the university while they heal mentally and physically from challenges faced before and during college. My qualitative research, based upon five years of participant observation, advances our understanding of the significance of ethnomusicology pioneer Mantle Hood’s theory of bi-musicality and the role of performance ensembles in current world music pedagogy, while also prompting a renewed appreciation for the presence of African and “African descended” music and dance instruction in higher education. This study contributes to the disciplines of African American studies, African musicology, dance studies, dance and movement therapy, education, and anthropology, while adding more specifically to the fields of cultural studies and ethnomusicology.

CNS relapse is reported in 2–5% of diffuse large B‐cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to treat given their commonly associated comorbidities. A retrospective analysis was performed of 270 DLBCL patients >80 years treated between 2004 and 2013 in two multicentre phase II LYSA trials (LNH03‐7B, LNH09‐7B) evaluating the addition of rituximab or ofatumumab to mini‐CHOP as front‐line therapy. No patients received CNS prophylaxis. CNS relapse was evaluated according to cumulative incidence, patient characteristics, risk factors, and survival. Median age was 83 years (range: 79–95). After a median follow‐up of 28.7 months, eight patients had CNS relapse (3.0%). Median time between inclusion and CNS relapse was 19.2 months (range: 3.2–32.6). Patients survived a median of 1.5 months after CNS relapse (range: 0.4–4.1). Median OS from relapse was significantly lower in CNS relapse patients (1.5 months, 95% CI: 0.4–3.5) compared to patients with non‐CNS relapse (6.6 months; 95% CI: 4.6–11.9). No baseline characteristics were associated with CNS relapse. The proportion of patients with CNS disease did not differ significantly between patients with low‐intermediate risk according to CNS‐IPI and patients with high risk (3% vs. 2.8%, P = 1.00). CNS relapse cumulative incidence in very elderly treatment‐naive patients is 1.8% at 2 years and is associated with poor survival. This population had a long median time to CNS relapse. Absence of prophylaxis did not strongly impact CNS relapse incidence.

Les lymphomes T périphériques sans autre précision (PTCL NOS) forment un groupe hétérogène de lymphomes. Leur diagnostic est difficile, leur pronostic péjoratif et les traitements actuels sont relativement peu efficaces. Afin d’avancer dans l’identification de nouveaux sous-groupes au sein de cette entité hétérogène, nous avons repris des prélèvements ganglionnaires afin de réaliser un état des lieux descriptif des caractéristiques au diagnostic d’une cohorte de PTCL NOS ganglionnaires exprimant des molécules de cytotoxicité (Perforine, Granzyme B et TIA-1). Les données cliniques, biologiques et anatomopathologiques de 39 patients ont été colligées et analysées. Nous confirmons l’existence d’un groupe particulier par sa présentation clinique sévère et son pronostic très sombre. Dans cette série, les patients étaient souvent des hommes jeunes, avec un lymphome disséminé et des scores pronostiques élevés. La perte du CD5 ou CD7 était fréquente et la moitié des prélèvements exprimait le CD8 et le TCRβ. L’expression du CD30 et un phénotype cytotoxique activé étaient très fréquents. Plus de la moitié des cas présentait un réarrangement clonal du gène codant pour les chaînes du TCR. Les scores IPI et PIT, l’expression du CD30 et un traitement intensif suivi d’autogreffe sont des facteurs prédictifs de survie. Un sous-groupe associé à l’EBV semble se distinguer, par un contexte particulier suggérant le rôle d’une stimulation antigénique et/ou d’un contexte d’immunomodulation sous-jacent. Cette base peut être utile afin de mieux caractériser ces lymphomes. Elle gagnerait à être enrichie dans le cadre du programme TENOMIC.