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401 results on '"Langholz, E."'

1. OC.04.7: A ONE-YEAR FOLLOW-UP STUDY ON CHECKPOINT INHIBITORINDUCED COLITIS: RESULTS FROM A EUROPEAN CONSORTIUM

Author

Lenti, M.V., primary, Broglio, G., additional, Ribaldone, D.G., additional, Schiepatti, A., additional, Vernero, M., additional, Cosentino, F., additional, Blesl, A., additional, Buda, A., additional, Croitoru, A., additional, Del Buono, A., additional, Aranzazu Jaurgeu, A., additional, Lasagna, A., additional, Carvalho, D., additional, Pugliese, D., additional, Langholz, E., additional, Dahl, E., additional, Savarino, E.V., additional, Agustoni, F., additional, De Andreis, F. Borrelli, additional, Caprioli, F., additional, Schaik, F., additional, Sottotetti, F., additional, Cammarota, G., additional, Ianiro, G., additional, Gröchenig, H.P., additional, Koutroubakis, I., additional, Geldolf, J., additional, Argyriou, K., additional, Foteinogiannopolou, K., additional, Bertani, L., additional, Lobaton Ortega, T., additional, Cappello, M., additional, Delliponti, M., additional, Demarzo, M.G., additional, Truyens, M., additional, Silvestris, N., additional, Ellul, J., additional, Cannizzaro, R., additional, Gabbiadini, R., additional, Pedrazzoli, P., additional, Spagnuolo, R., additional, Saglio, S., additional, Stroie, T.G., additional, Natalello, G., additional, Varallo, M., additional, La Torre, M.A., additional, Petrucci, C., additional, Klersey, C., additional, Corazza, G.R., additional, and Di Sabatino, A., additional

Published
2024
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2. Disease course of Crohn's disease during the first ten years following diagnosis in a prospective European population-based inception cohort - the Epi-IBD cohort

Author

Wewer, M. D., Salupere, R., Kievit, H. A. L., Nielsen, K. R., Midjord, J., Domislovic, V., Krznarić, Ž., Pedersen, N., Kjeldsen, J., Eriksson, Carl, Halfvarson, Jonas, Talbot, A., Sebastian, S., Goldis, A., Misra, R., Arebi, N., Ilus, T., Oksanen, P., Neuman, A., Andersen, V., Skamnelos, A., Katsanos, K. H., Platon, V., Turcan, S., Borg, B., Ellul, P., Kupcinskas, J., Kiudelis, G., Yzet, C., Fumery, M., Kaimakliotis, I. P., Lorenzon, G., D'Inca, R., Hernandez, V., Fernandez, A., Langholz, E., Munkholm, P., Burisch, J., Wewer, M. D., Salupere, R., Kievit, H. A. L., Nielsen, K. R., Midjord, J., Domislovic, V., Krznarić, Ž., Pedersen, N., Kjeldsen, J., Eriksson, Carl, Halfvarson, Jonas, Talbot, A., Sebastian, S., Goldis, A., Misra, R., Arebi, N., Ilus, T., Oksanen, P., Neuman, A., Andersen, V., Skamnelos, A., Katsanos, K. H., Platon, V., Turcan, S., Borg, B., Ellul, P., Kupcinskas, J., Kiudelis, G., Yzet, C., Fumery, M., Kaimakliotis, I. P., Lorenzon, G., D'Inca, R., Hernandez, V., Fernandez, A., Langholz, E., Munkholm, P., and Burisch, J.

Published
2023
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3. Disease course of Ulcerative Colitis during the first ten years following diagnosis in a prospective European population-based inception cohort - the Epi-IBD cohort

Author

Wewer, M. D., Salupere, R., Kievit, H. A. L., Nielsen, K. R., Midjord, J., Domislovic, V., Krznarić, Ž., Pedersen, N., Jens, K., Eriksson, Carl, Halfvarson, Jonas, Talbot, A., Sebastian, S., Goldis, A., Misra, R., Arebi, N., Ilus, T., Oksanen, P., Neuman, A., Andersen, V., Skamnelos, A., Katsanos, K. H., Negru, I., Turcan, S., Borg, B., Ellul, P., Kupcinskas, J., Kiudelis, G., Yzet, C., Fumery, M., Kaimakliotis, I. P., Lorenzon, G., D'Inca, R., Hernandez, V., Fernandez, A., Langholz, E., Munkholm, P., Burisch, J., Wewer, M. D., Salupere, R., Kievit, H. A. L., Nielsen, K. R., Midjord, J., Domislovic, V., Krznarić, Ž., Pedersen, N., Jens, K., Eriksson, Carl, Halfvarson, Jonas, Talbot, A., Sebastian, S., Goldis, A., Misra, R., Arebi, N., Ilus, T., Oksanen, P., Neuman, A., Andersen, V., Skamnelos, A., Katsanos, K. H., Negru, I., Turcan, S., Borg, B., Ellul, P., Kupcinskas, J., Kiudelis, G., Yzet, C., Fumery, M., Kaimakliotis, I. P., Lorenzon, G., D'Inca, R., Hernandez, V., Fernandez, A., Langholz, E., Munkholm, P., and Burisch, J.

Published
2023
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5. Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: Results of the 2011 ECCO-EpiCom inception cohort

Author

Vegh, Z., Burisch, J., Pedersen, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Avnstrøm, S., Vinding, K. Kofod, Olsen, J., Nielsen, K.R., Katsanos, K.H., Tsianos, E.V., Lakatos, L., Schwartz, D., Odes, S., Lupinacci, G., De Padova, A., Jonaitis, L., Kupcinskas, L., Turcan, S., Tighineanu, O., Mihu, I., Barros, L.F., Magro, F., Lazar, D., Goldis, A., Fernandez, A., Hernandez, V., Niewiadomski, O., Bell, S., Langholz, E., Munkholm, P., and Lakatos, P.L.

Published
2014
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6. Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease — An ECCO-EpiCom study

Author

Burisch, J., Weimers, P., Pedersen, N., Cukovic-Cavka, S., Vucelic, B., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J.F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K.R., Manninen, P., Collin, P., Katsanos, K.H., Tsianos, E.V., Ladefoged, K., Lakatos, L., Ragnarsson, G., Björnsson, E., Bailey, Y., O'Morain, C., Schwartz, D., Odes, S., Valpiani, D., Boni, M.C., Jonaitis, L., Kupcinskas, L., Turcan, S., Barros, L., Magro, F., Lazar, D., Goldis, A., Nikulina, I., Belousova, E., Fernandez, A., Sanroman, L., Almer, S., Zhulina, Y., Halfvarson, J., Arebi, N., Diggory, T., Sebastian, S., Lakatos, P.L., Langholz, E., and Munkholm, P.

Published
2014
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7. Health care and patients' education in a European inflammatory bowel disease inception cohort: An ECCO-EpiCom study

Author

Burisch, J., Vegh, Z., Pedersen, N., Čuković-Čavka, S., Turk, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J.F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K.R., Manninen, P., Collin, P., Katsanos, K.H., Tsianos, E.V., Ladefoged, K., Ragnarsson, G., Björnsson, E., Bailey, Y., O'Morain, C., Schwartz, D., Odes, S., Politi, P., Santini, A., Kiudelis, G., Kupcinskas, L., Turcan, S., Magro, F., Barros, L., Lazar, D., Goldis, A., Nikulina, I., Belousova, E., Sanromán, L., Martinez-Ares, D., Almer, S., Zhulina, Y., Halfvarson, J., Arebi, N., Houston, Y., Sebastian, S., Langholz, E., Lakatos, P.L., and Munkholm, P.

Published
2014
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8. Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe — An ECCO-EpiCom study

Author

Burisch, J., Pedersen, N., Cukovic-Cavka, S., Turk, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J.F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K.R., Manninen, P., Collin, P., Katsanos, K.H., Tsianos, E.V., Ladefoged, K., Lakatos, L., Ragnarsson, G., Björnsson, E., Bailey, Y., O'Morain, C., Schwartz, D., Odes, S., Giannotta, M., Girardin, G., Kiudelis, G., Kupcinskas, L., Turcan, S., Barros, L., Magro, F., Lazar, D., Goldis, A., Nikulina, I., Belousova, E., Martinez-Ares, D., Hernandez, V., Almer, S., Zhulina, Y., Halfvarson, J., Arebi, N., Tsai, H.H., Sebastian, S., Lakatos, P.L., Langholz, E., and Munkholm, P.

Published
2014
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9. DOP019 Immunomodulators reduce the risk of surgery and hospitalisation in Crohn’s disease in a prospective European population-based inception cohort: the Epi-IBD cohort

Author

Burisch, J, Andersen, V, Čuković-Čavka, S, Lakatos, P L, DʼInca, R, Magro, F, Arebi, N, Kievit, L, Kaimakliotis, I, Valpiani, D, Katsanos, K H, Vegh, Z, Dahlerup, J F, Fumery, M, Pedersen, N, Halfvarson, J, Belousova, E, Nielsen, K R, Turcan, S, Ellul, P, Kupcinskas, L, Oksanen, P, Duricova, D, Giannotta, M, Goldis, A, Hernandez, V, Salupere, R, Odes, S, Langholz, E, and Munkholm, P

Published
2018
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10. P695 The risk of proximal disease extension in patients with limited ulcerative colitis in a prospective European population-based inception cohort – the ECCO-EpiCom cohort

Author

Burisch, J., Halfvarson, J., Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J.F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K.R., Giannotta, M., Oksanen, P., Katsanos, K.H., Vegh, Z., Ellul, P., Schwartz, D., Čuković-Čavka, S., DʼIncà, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P.L., and Munkholm, P.

Published
2017
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11. P727 Change in Crohnʼs disease behavior in a prospective European population-based inception cohort – the ECCO-EpiCom cohort

Author

Burisch, J., Halfvarson, J., Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J.F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K.R., Giannotta, M., Oksanen, P., Katsanos, K.H., Vegh, Z., Ellul, P., Schwartz, D., Čuković-Čavka, S., DʼIncà, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P.L., and Munkholm, P.

Published
2017
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12. P694 Disease course during the first five years following diagnosis in a prospective European population-based inception cohort – the ECCO-EpiCom cohort

Author

Burisch, J., Halfvarson, J., Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J.F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K.R., Giannotta, M., Oksanen, P., Katsanos, K.H., Vegh, Z., Ellul, P., Schwartz, D., Čuković-Čavka, S., DʼIncà, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P.L., and Munkholm, P.

Published
2017
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16. East–West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort

Author

Burisch, J, Pedersen, N, Čuković-Čavka, S, Brinar, M, Kaimakliotis, I, Duricova, D, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Andersen, V, Krabbe, S, Dahlerup, J F, Salupere, R, Nielsen, K R, Olsen, J, Manninen, P, Collin, P, Tsianos, E V, Katsanos, K H, Ladefoged, K, Lakatos, L, Björnsson, E, Ragnarsson, G, Bailey, Y, Odes, S, Schwartz, D, Martinato, M, Lupinacci, G, Milla, M, De Padova, A, DʼIncà, R, Beltrami, M, Kupcinskas, L, Kiudelis, G, Turcan, S, Tighineanu, O, Mihu, I, Magro, F, Barros, L F, Goldis, A, Lazar, D, Belousova, E, Nikulina, I, Hernandez, V, Martinez-Ares, D, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Sebastian, S, Lakatos, P L, Langholz, E, and Munkholm, P

Published
2014
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22. Phenotype at diagnosis predicts recurrence rates in Crohn's disease

Author

Wolters, F.L., Russel, M.G., Sijbrandij, J., Ambergen, T., Odes, S., Riis, L., Langholz, E., Politi, P., Qasim, A., Koutroubakis, I., Tsianos, E., Vermeire, S., Freitas, J., van Zeijl, G., Hoie, O., Bernklev, T., Beltrami, M., Rodriguez, D., Stockbrugger, R.W., and Moum, B.

Subjects
Crohn's disease -- Research, Crohn's disease -- Diagnosis, Crohn's disease -- Risk factors, Phenotype -- Research, Phenotype -- Physiological aspects, Health
Published
2006

24. OP35 Treatment outcomes of inflammatory bowel disease in the biological era—a nationwide retrospective cohort study in three Nordic countries: Results from the TRINordic study

Author

Zhao, M, primary, Lördal, M, additional, Langholz, E, additional, Knudsen, T, additional, Voutilainen, M, additional, Høivik, M L, additional, Moum, B, additional, Saebo, B, additional, Haiko, P, additional, Malmgren, C, additional, Coskun, M, additional, Melberg, H O, additional, and Burisch, J, additional

Published
2020
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25. P243 Changes in the therapeutic management of inflammatory bowel disease in the biological era – a nationwide retrospective cohort study in three Nordic countries: Results from the TRINordic study

Author

Zhao, M, primary, Lördal, M, additional, Langholz, E, additional, Knudsen, T, additional, Voutilainen, M, additional, Høivik, M L, additional, Moum, B, additional, Saebo, B, additional, Haiko, P, additional, Malmgren, C, additional, Coskun, M, additional, Melberg, H O, additional, and Burisch, J, additional

Published
2020
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26. DOP21 Time to first treatment with biologic agents for ulcerative colitis and Crohn’s disease across four Nordic countries: Results from the TRINordic study

Author

Høivik, M, primary, Lördal, M, additional, Burisch, J, additional, Langholz, E, additional, Knudsen, T, additional, Voutilainen, M, additional, Moum, B, additional, Anisdahl, K, additional, Saebo, B, additional, Haiko, P, additional, Malmgren, C, additional, Coskun, M, additional, and Melberg, H O, additional

Published
2020
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31. Cost analysis in a prospective European population-based inception cohort : is there a cost-saving effect of biological therapy?

Author

Burisch, J., Vardi, H., Schwartz, D., Krznaric, Z., Lakatos, P. L., Fumery, M., Kupcinskas, L., Magro, F., Belousova, E., Oksanen, P., Arebi, N., Langholz, E., Turcan, S., D'Inca, R., Hernandez, V., Valpiani, D., Vegh, Z., Giannotta, M., Katsanos, K. H., Duricova, D., Nielsen, K. R., Kievit, H. A. L., Ellul, P., Salupere, R., Goldis, A., Kaimakliotis, I., Pedersen, N., Andersen, V., Halfvarson, Jonas, Sebastian, S., Dahlerup, J. F., Munkholm, P., Odes, S., Burisch, J., Vardi, H., Schwartz, D., Krznaric, Z., Lakatos, P. L., Fumery, M., Kupcinskas, L., Magro, F., Belousova, E., Oksanen, P., Arebi, N., Langholz, E., Turcan, S., D'Inca, R., Hernandez, V., Valpiani, D., Vegh, Z., Giannotta, M., Katsanos, K. H., Duricova, D., Nielsen, K. R., Kievit, H. A. L., Ellul, P., Salupere, R., Goldis, A., Kaimakliotis, I., Pedersen, N., Andersen, V., Halfvarson, Jonas, Sebastian, S., Dahlerup, J. F., Munkholm, P., and Odes, S.

Published
2019
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36. Immunomodulators reduce the risk of surgery and hospitalisation in Crohn’s disease in a prospective European population-based inception cohort: the Epi-IBD cohort

Author

Burisch, J., Andersen, V., Cukovic-Cavka, S., Lakatos, P. L., D Inca, R., Magro, F., Arebi, N., Kievit, L., Kaimakliotis, I., Valpiani, D., Katsanos, K. H., Vegh, Z., Dahlerup, J. F., Fumery, M., Pedersen, N., Halfvarson, J., Belousova, E., Nielsen, K. R., Turcan, S., Ellul, P., Kupcinskas, L., Oksanen, P., Duricova, D., Giannotta, M., Goldis, A., Vicent Hernandez, Salupere, R., Odes, S., Langholz, E., and Munkholm, P.

Subjects
616.344-002-031.84 [udc], Crohn disease, diagnosis, therapy, Biological therapy, methods, Immunologic factors, therapeutic use, Cohort studies, Regression analysis, Europe
Abstract

Background: Immunomodulators have both been shown to improve the disease course in IBD patients: however, the literature remains inconsistent. The aim of the study was to investigate the impact of treatment with immunomodulators and biological therapy on disease course and prognosis of patients diagnosed with Crohn’s disease (CD) from diagnosis and during the first 5 years of follow-up. Methods: The Epi-IBD cohort is a prospective population-based cohort of 1289 unselected, uniformly diagnosed patients with IBD diagnosed in 2010 in centres from Western and Eastern European countries. Clinical data were captured prospectively throughout the follow-up period. Associations between primary endpoints (surgery and hospitalisation) and covariates were analysed by stepwise Cox regression analysis using the proportional hazards assumption. The use of immunomodulators and biologics were included as time-dependent variables with an initial lag time of 3 months and 2 months, respectively. Results: A total of 488 (38%) patients were diagnosed with CD and included in the study. Patient characteristics are shown in Table 1. Prevalence of treatments on any given day during follow-up is shown in Figure 1. In total, 107 CD patients (22%) had a resection, while 176 (36%) patients were hospitalised because of CD. Treatment with immunomodulators was associated with a reduced risk of surgery (HR: 0.4 CI95% 0.2–0.6) as well as needing hospitalisation (HR: 0.3 CI95% 0.2–0.5) (Figure 2), while biological therapy was not (HR: 0.8 (0.4–1.3) and HR: 0.7 (0.5–1.2)). Other factors included in the regression analusis are shown in Table 2 [...].

Published
2018

37. Natural disease course of inflammatory bowel disease unclassified in a prospective European population-based inception cohort-the Epi-IBD cohort

Author

Burisch, J., Ellul, P., Arebi, N., Kaimakliotis, I., D'Inca, R., Andersen, V., Belousova, E., Hernandez, V., Vegh, Z., Turcan, S., Magro, F., Kupcinskas, L., Halfvarson, Jonas, Lakatos, P. L., Duricova, D., Kievit, L., Goldis, A., Dahlerup, J. F., Oksanen, P., Cukovic-Cavka, S., Fumery, M., Odes, S., Nielsen, K. R., Valpiani, D., Pedersen, N., Giannotta, M., Salupere, R., Katsanos, K. H., Langholz, E., Munkholm, P., Burisch, J., Ellul, P., Arebi, N., Kaimakliotis, I., D'Inca, R., Andersen, V., Belousova, E., Hernandez, V., Vegh, Z., Turcan, S., Magro, F., Kupcinskas, L., Halfvarson, Jonas, Lakatos, P. L., Duricova, D., Kievit, L., Goldis, A., Dahlerup, J. F., Oksanen, P., Cukovic-Cavka, S., Fumery, M., Odes, S., Nielsen, K. R., Valpiani, D., Pedersen, N., Giannotta, M., Salupere, R., Katsanos, K. H., Langholz, E., and Munkholm, P.

Published
2018

38. Validation of the 'United Registries for Clinical Assessment and Research' [UR-CARE], a European online registry for clinical care and research in inflammatory bowel disease

Author

Burisch, J., Gisbert, J.P., Siegmund, B., Bettenworth, D., Thomsen, S.B., Cleynen, Isabelle, Cremer, Anneline, Sheng Ding, N.J., Furfaro, F., Galanopoulos, M., Grunert, P.C., Hanzel, J., Ivanovski, T.K., Krustins, E., Noor, N., O'Morain, N., Rodríguez-Lago, I., Scharl, M., Tua, J., Uzzan, M., Yassin, N.A., Baert, Filip, Langholz, E., Burisch, J., Gisbert, J.P., Siegmund, B., Bettenworth, D., Thomsen, S.B., Cleynen, Isabelle, Cremer, Anneline, Sheng Ding, N.J., Furfaro, F., Galanopoulos, M., Grunert, P.C., Hanzel, J., Ivanovski, T.K., Krustins, E., Noor, N., O'Morain, N., Rodríguez-Lago, I., Scharl, M., Tua, J., Uzzan, M., Yassin, N.A., Baert, Filip, and Langholz, E.

Abstract

Background: The 'United Registries for Clinical Assessment and Research' [UR-CARE] database is an initiative of the European Crohn's and Colitis Organisation [ECCO] to facilitate daily patient care and research studies in inflammatory bowel disease [IBD]. Herein, we sought to validate the database by using fictional case histories of patients with IBD that were to be entered by observers of varying experience in IBD. Methods: Nineteen observers entered five patient case histories into the database. After 6 weeks, all observers entered the same case histories again. For each case history, 20 key variables were selected to calculate the accuracy for each observer. We assumed that the database was such that = 90% of the entered data would be correct. The overall proportion of correctly entered data was calculated using a beta-binomial regression model to account for inter-observer variation and compared to the expected level of validity. Re-test reliability was assessed using McNemar's test. Results: For all case histories, the overall proportion of correctly entered items and their confidence intervals included the target of 90% (Case 1: 92% [88-94%]; Case 2: 87% [83-91%]; Case 3: 93% [90-95%]; Case 4: 97% [94-99%]; Case 5: 91% [87-93%]). These numbers did not differ significantly from those found 6 weeks later [NcNemar's test p > 0.05]. Conclusion: The UR-CARE database appears to be feasible, valid and reliable as a tool and easy to use regardless of prior user experience and level of clinical IBD experience. UR-CARE has the potential to enhance future European collaborations regarding clinical research in IBD., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

39. Disease course during the first five years following diagnosis in a prospective European population-based inception cohort - the ECCO-EpiCom cohort

Author

Burisch, J., Halfvarson, Jonas, Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J. F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K. R., Giannotta, M., Oksanen, P., Katsanos, K. H., Vegh, Z., Ellul, P., Schwartz, D., Cukovic-Cavka, S., D'Inca, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P. L., Munkholm, P., Burisch, J., Halfvarson, Jonas, Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J. F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K. R., Giannotta, M., Oksanen, P., Katsanos, K. H., Vegh, Z., Ellul, P., Schwartz, D., Cukovic-Cavka, S., D'Inca, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P. L., and Munkholm, P.

Published
2017
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40. Change in Crohn's disease behavior in a prospective European population-based inception cohort - the ECCO-EpiCom cohort

Author

Burisch, J., Halfvarson, Jonas, Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J. F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K. R., Giannotta, M., Oksanen, P., Katsanos, K. H., Vegh, Z., Ellul, P., Schwartz, D., Cukovic-Cavka, S., D'Inca, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P. L., Munkholm, P., Burisch, J., Halfvarson, Jonas, Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J. F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K. R., Giannotta, M., Oksanen, P., Katsanos, K. H., Vegh, Z., Ellul, P., Schwartz, D., Cukovic-Cavka, S., D'Inca, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P. L., and Munkholm, P.

Published
2017
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41. The risk of proximal disease extension in patients with limited ulcerative colitis in a prospective European population-based inception cohort - the ECCO-EpiCom cohort

Author

Burisch, J., Halfvarson, Jonas, Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J. F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K. R., Giannotta, M., Oksanen, P., Katsanos, K. H., Vegh, Z., Ellul, P., Schwartz, D., Cukovic-Cavka, S., D'Inca, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P. L., Munkholm, P., Burisch, J., Halfvarson, Jonas, Kupcinskas, L., Hernandez, V., Kaimakliotis, I., Valpiani, D., Pedersen, N., Duricova, D., Kievit, L., Dahlerup, J. F., Fumery, M., Salupere, R., Arebi, N., Nielsen, K. R., Giannotta, M., Oksanen, P., Katsanos, K. H., Vegh, Z., Ellul, P., Schwartz, D., Cukovic-Cavka, S., D'Inca, R., Turcan, S., Magro, F., Goldis, A., Langholz, E., Lakatos, P. L., and Munkholm, P.

Published
2017
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43. Frequency of anaemia and anaemia subtypes in east-west European inception cohort : an ECCO-EpiCom cohort study

Author

Burisch, J., Gerdes, U., Almer, S., Cukovic-Cavka, S., Sebastian, S., Kaimakliotis, I., Duricova, D., Pedersen, N., Salupere, R., Nielsen, K. R., Manninen, P., Katsanos, K. H., Odes, S., Andersen, V., D'Inca, R., Kupcinskas, L., Turcan, S., Magro, F., Goldis, A., Vinding, K. Kofod, Belousova, E., Ladefoged, K., Bailey, Y., Hernandez, V., Halfvarson, Jonas, Arebi, N., Shonova, O., Hoivik, M. L., Moum, B., Langholz, E., Lakatos, P. L., Munkholm, P., Dahlerup, J. F., Burisch, J., Gerdes, U., Almer, S., Cukovic-Cavka, S., Sebastian, S., Kaimakliotis, I., Duricova, D., Pedersen, N., Salupere, R., Nielsen, K. R., Manninen, P., Katsanos, K. H., Odes, S., Andersen, V., D'Inca, R., Kupcinskas, L., Turcan, S., Magro, F., Goldis, A., Vinding, K. Kofod, Belousova, E., Ladefoged, K., Bailey, Y., Hernandez, V., Halfvarson, Jonas, Arebi, N., Shonova, O., Hoivik, M. L., Moum, B., Langholz, E., Lakatos, P. L., Munkholm, P., and Dahlerup, J. F.

Published
2016
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44. Unchanged surgery and hospitalization rates in an East-West European inception cohort despite differences in use of biologicals-3-year follow-up of the ECCO-EpiCom cohort

Author

Burisch, J., Kaimakliotis, I., Duricova, D., Kievit, L., Dahlerup, J. F., Salupere, R., Nielsen, K. R., Manninen, P., Tsianos, E. V., Vegh, Z., Odes, S., D'Inca, R., Kupcinskas, L., Turcan, S., Magro, F., Goldis, A., Hernandez, V., Halfvarson, Jonas, Arebi, N., Langholz, E., Lakatos, P. L., Munkholm, P., EpiCom Northern Italy, Group author, Burisch, J., Kaimakliotis, I., Duricova, D., Kievit, L., Dahlerup, J. F., Salupere, R., Nielsen, K. R., Manninen, P., Tsianos, E. V., Vegh, Z., Odes, S., D'Inca, R., Kupcinskas, L., Turcan, S., Magro, F., Goldis, A., Hernandez, V., Halfvarson, Jonas, Arebi, N., Langholz, E., Lakatos, P. L., Munkholm, P., and EpiCom Northern Italy, Group author

Abstract

Note: D'Inca R., On behalf of the EpiCom Northern Italy, Florence, Forlì, and Padova, Italy

Published
2015
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45. Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort

Author

Vegh, Z, Burisch, J, Pedersen, N., Kaimakliotis, I, Duricova, D, Bortlik, M, Vinding, K Kofod, Avnstrøm, S, Olsen, J., Nielsen, K R, Katsanos, K H, Tsianos, E V, Lakatos, L, Schwartz, D, Odes, S, D'Incà, R, Beltrami, M, Kiudelis, G, Kupcinskap, L, Jucov, A, Turcan, S, Barros, L F, Magro, F, Lazar, D, Goldis, A, de Castro, L, Hernandez, V, Niewiadomski, O, Bell, S, Langholz, E, Munkholm, P, Lakatos, P L, Vegh, Z, Burisch, J, Pedersen, N., Kaimakliotis, I, Duricova, D, Bortlik, M, Vinding, K Kofod, Avnstrøm, S, Olsen, J., Nielsen, K R, Katsanos, K H, Tsianos, E V, Lakatos, L, Schwartz, D, Odes, S, D'Incà, R, Beltrami, M, Kiudelis, G, Kupcinskap, L, Jucov, A, Turcan, S, Barros, L F, Magro, F, Lazar, D, Goldis, A, de Castro, L, Hernandez, V, Niewiadomski, O, Bell, S, Langholz, E, Munkholm, P, and Lakatos, P L

Abstract

Background and Aims: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis. Methods: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn’s disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients’ data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu]. Results: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93]. Conclusions: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres., BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu].RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93].CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.

Published
2015

46. East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort

Author

Burisch, J., Pedersen, N., Cukovic-Cavka, S., Brinar, M., Kaimakliotis, I., Duricova, D., Shonova, O., Vind, I., Avnstrom, S., Thorsgaard, N., Andersen, V., Krabbe, S., Dahlerup, J.F., Salupere, R., Nielsen, K.R., Olsen, J., Manninen, P., Collin, P., Tsianos, E.V., Katsanos, K.H., Ladefoged, K., Lakatos, L., Bjornsson, E., Ragnarsson, G., Bailey, Y., Odes, S., Schwartz, D., Martinato, M., Lupinacci, G., Milla, M., De Padova, A., D'lnca, R., Beltrami, M., Kupcinskas, L., Kiudelis, G., Turcan, S., Tighineanu, O., Mihu, I., Magro, F., Barros, L.F., Goldis, A., Lazar, D., Belousova, E., Nikulina, I., Hernandez, V., Martinez-Ares, D., Almer, Sven, Zhulina, Y., Halfvarson, J., Arebi, N., Sebastian, S., Lakatos, P.L., Langholz, E., Munkholm, P., Burisch, J., Pedersen, N., Cukovic-Cavka, S., Brinar, M., Kaimakliotis, I., Duricova, D., Shonova, O., Vind, I., Avnstrom, S., Thorsgaard, N., Andersen, V., Krabbe, S., Dahlerup, J.F., Salupere, R., Nielsen, K.R., Olsen, J., Manninen, P., Collin, P., Tsianos, E.V., Katsanos, K.H., Ladefoged, K., Lakatos, L., Bjornsson, E., Ragnarsson, G., Bailey, Y., Odes, S., Schwartz, D., Martinato, M., Lupinacci, G., Milla, M., De Padova, A., D'lnca, R., Beltrami, M., Kupcinskas, L., Kiudelis, G., Turcan, S., Tighineanu, O., Mihu, I., Magro, F., Barros, L.F., Goldis, A., Lazar, D., Belousova, E., Nikulina, I., Hernandez, V., Martinez-Ares, D., Almer, Sven, Zhulina, Y., Halfvarson, J., Arebi, N., Sebastian, S., Lakatos, P.L., Langholz, E., and Munkholm, P.

Abstract

Objective The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East–West gradient in the incidence of IBD in Europe exists. Design A prospective, uniformly diagnosed, population based inception cohort of IBD patients in 31 centres from 14 Western and eight Eastern European countries covering a total background population of approximately 10.1 million people was created. One-third of the centres had previous experience with inception cohorts. Patients were entered into a low cost, web based epidemiological database, making participation possible regardless of socioeconomic status and prior experience. Results 1515 patients aged 15 years or older were included, of whom 535 (35%) were diagnosed with Crohn's disease (CD), 813 (54%) with ulcerative colitis (UC) and 167 (11%) with IBD unclassified (IBDU). The overall incidence rate ratios in all Western European centres were 1.9 (95% CI 1.5 to 2.4) for CD and 2.1 (95% CI 1.8 to 2.6) for UC compared with Eastern European centres. The median crude annual incidence rates per 100 000 in 2010 for CD were 6.5 (range 0–10.7) in Western European centres and 3.1 (range 0.4–11.5) in Eastern European centres, for UC 10.8 (range 2.9–31.5) and 4.1 (range 2.4–10.3), respectively, and for IBDU 1.9 (range 0–39.4) and 0 (range 0–1.2), respectively. In Western Europe, 92% of CD, 78% of UC and 74% of IBDU patients had a colonoscopy performed as the diagnostic procedure compared with 90%, 100% and 96%, respectively, in Eastern Europe. 8% of CD and 1% of UC patients in both regions underwent surgery within the first 3 months of the onset of disease. 7% of CD patients and 3% of UC patients from Western Europe received biological treatment as rescue therapy. Of all European CD patients, 20% received only 5-aminosalicylates as induction therapy. Conclusions An East–West gradient in IBD incidence exists in Europe. Among

Published
2014
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47. The cost of investigations and medical treatment including biological therapy in a European inception cohort from the biological era : An ECCO-EpiCom study

Author

Burisch, J., Kaimakliotis, I., Duricova, D., Thorsgaard, N., Andersen, V., Nielsen, K. R., Tsianos, E. V., Ladefoged, K., Bailey, Y., D'Inca, R., Kupcinskas, L., Turcan, S., Magro, F., Goldis, A., Belousova, E., Hernandez, V., Almer, S., Halfvarson, Jonas, Sebastian, S., Langholz, E., Odes, S., Munkholm, P., Burisch, J., Kaimakliotis, I., Duricova, D., Thorsgaard, N., Andersen, V., Nielsen, K. R., Tsianos, E. V., Ladefoged, K., Bailey, Y., D'Inca, R., Kupcinskas, L., Turcan, S., Magro, F., Goldis, A., Belousova, E., Hernandez, V., Almer, S., Halfvarson, Jonas, Sebastian, S., Langholz, E., Odes, S., and Munkholm, P.

Published
2014
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48. Health care and patients' education in a European inflammatory bowel disease inception cohort:An ECCO-EpiCom study

Author

Burisch, J, Vegh, Z, Pedersen, Natalia, Cuković-Čavka, S, Turk, N, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, J F, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, K R, Manninen, P, Collin, P, Katsanos, K H, Tsianos, E V, Ladefoged, K, Ragnarsson, G, Björnsson, E, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Politi, P, Santini, A, Kiudelis, G, Kupcinskas, L, Turcan, S, Magro, F, Barros, L, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Sanromán, L, Martinez-Ares, D, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Houston, Y, Sebastian, S, Langholz, E, Lakatos, P L, Munkholm, P, Burisch, J, Vegh, Z, Pedersen, Natalia, Cuković-Čavka, S, Turk, N, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, J F, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, K R, Manninen, P, Collin, P, Katsanos, K H, Tsianos, E V, Ladefoged, K, Ragnarsson, G, Björnsson, E, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Politi, P, Santini, A, Kiudelis, G, Kupcinskas, L, Turcan, S, Magro, F, Barros, L, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Sanromán, L, Martinez-Ares, D, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Houston, Y, Sebastian, S, Langholz, E, Lakatos, P L, and Munkholm, P

Abstract

BACKGROUND AND AIMS: The EpiCom study and inception cohort was initiated in 2010 in 31 centers from 14 Western and 8 Eastern European countries, covering a 10.1million person background population. Our aim was to investigate whether there is a difference between Eastern and Western Europe in health care and education of patients with inflammatory bowel disease (IBD).METHODS: A quality of care (QoC) questionnaire was developed in the EpiCom group consisting of 16 questions covering 5 items: time interval between the onset of symptoms and diagnosis, information, education, empathy and access to health care providers.RESULTS: Of 1,515 patients, 947 (217 east/730 west) answered the QoC questionnaire. Only 23% of all patients had knowledge about IBD before diagnosis. In Eastern Europe, significantly more patients searched out information about IBD themselves (77% vs. 68%, p<0.05), the main source was the Internet (92% vs. 88% p=0.23). In Western Europe, significantly more patients were educated by nurses (19% vs. 1%, p<0.05), while in Eastern Europe, gastroenterologists were easier to contact (80% vs. 68%, p<0.05).CONCLUSION: Health care differed significantly between Eastern and Western Europe in all items, but satisfaction rates were high in both geographic regions. Because of the low awareness and the rising incidence of IBD, general information should be the focus of patient organizations and medical societies. In Western Europe IBD nurses play a very important role in reducing the burden of patient management.

Published
2014

49. Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe:An ECCO-EpiCom study

Author

Burisch, J, Pedersen, Natalia, Cukovic-Cavka, S, Turk, N, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Vind, Ida, Avnstrøm, S, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, J F, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, K R, Manninen, P, Collin, P, Katsanos, K H, Tsianos, E V, Ladefoged, K, Lakatos, L, Ragnarsson, G, Björnsson, E, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Giannotta, M, Girardin, G, Kiudelis, G, Kupcinskas, L, Turcan, S, Barros, L, Magro, F, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Martinez-Ares, D, Hernandez, V, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Tsai, H H, Langholz, E, Munkholm, P, Burisch, J, Pedersen, Natalia, Cukovic-Cavka, S, Turk, N, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Vind, Ida, Avnstrøm, S, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, J F, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, K R, Manninen, P, Collin, P, Katsanos, K H, Tsianos, E V, Ladefoged, K, Lakatos, L, Ragnarsson, G, Björnsson, E, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Giannotta, M, Girardin, G, Kiudelis, G, Kupcinskas, L, Turcan, S, Barros, L, Magro, F, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Martinez-Ares, D, Hernandez, V, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Tsai, H H, Langholz, E, and Munkholm, P

Abstract

BACKGROUND AND AIMS: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients.METHODS: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1 million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors.RESULTS: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p<0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p<0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p<0.01).CONCLUSIONS: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.

Published
2014

50. Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia:Results of the 2011 ECCO-EpiCom inception cohort

Author

Vegh, Z, Burisch, J., Pedersen, N., Kaimakliotis, I, Duricova, D, Bortlik, M, Avnstrøm, S, Vinding, K Kofod, Olsen, J., Nielsen, K R, Katsanos, K H, Tsianos, E V, Lakatos, L, Schwartz, D, Odes, S, Lupinacci, G, De Padova, A, Jonaitis, L, Kupcinskas, L, Turcan, S, Tighineanu, O, Mihu, I, Barros, L F, Magro, F, Lazar, D, Goldis, A, Fernandez, A, Hernandez, V, Niewiadomski, O, Bell, S, Langholz, E, Munkholm, P, Lakatos, P L, Vegh, Z, Burisch, J., Pedersen, N., Kaimakliotis, I, Duricova, D, Bortlik, M, Avnstrøm, S, Vinding, K Kofod, Olsen, J., Nielsen, K R, Katsanos, K H, Tsianos, E V, Lakatos, L, Schwartz, D, Odes, S, Lupinacci, G, De Padova, A, Jonaitis, L, Kupcinskas, L, Turcan, S, Tighineanu, O, Mihu, I, Barros, L F, Magro, F, Lazar, D, Goldis, A, Fernandez, A, Hernandez, V, Niewiadomski, O, Bell, S, Langholz, E, Munkholm, P, and Lakatos, P L

Abstract

BACKGROUND AND AIMS: The aim of the present study was to validate the IBD (inflammatory bowel diseases) incidence reported in the 2010 ECCO-EpiCom (European Crohn's and Colitis Organization-Epidemiological Committee) inception cohort by including a second independent inception cohort from participating centers in 2011 and an Australian center to investigate whether there is a difference in the incidence of IBD between Eastern and Western European countries and Australia.METHODS: Fourteen centers from 5 Eastern and 9 Western European countries and one center from Australia participated in the ECCO-EpiCom 2011 inception cohort. Patients' data regarding disease type, socio-demographic factors, extraintestinal manifestations and therapy were entered into the Web-based EpiCom database, www.ecco-epicom.eu.RESULTS: A total of 711 adult patients were diagnosed during the inclusion year 2011, 178 (25%) from Eastern, 461 (65%) from Western Europe and 72 (10%) from Australia; 259 (37%) patients were diagnosed with Crohn's disease, 380 (53%) with ulcerative colitis and 72 (10%) with IBD unclassified. The mean annual incidence rate for IBD was 11.3/100,000 in Eastern Europe, 14.0/100,000 in Western Europe and 30.3/100,000 in Australia. Significantly more patients were diagnosed with complicated disease at diagnosis in Eastern Europe compared to Western Europe (43% vs. 27%, p=0.02).CONCLUSION: Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort.

Published
2014

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