19 results on '"Kusumoto, G."'
Search Results
2. Neuromuscular Blockade by Vecuronium during Induction with 5% Sevoflurane or Propofol
- Author
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Nitahara, K, primary, Sugi, Y, additional, Kusumoto, G, additional, Shono, S, additional, Iwashita, K, additional, and Higa, K, additional
- Published
- 2010
- Full Text
- View/download PDF
3. Hepatic circulation and oxygen metabolism during sevoflurane, isoflurane or halothane anesthesia with hypoxemia in the dogs
- Author
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Matsumoto, N., primary, Abe, T., additional, Narita, Y., additional, Kusumoto, G., additional, Tsuchiya, M., additional, and Mizukami, S., additional
- Published
- 2004
- Full Text
- View/download PDF
4. Third-Generation Hydroxyethyl Starch Causes Dose-Dependent Coagulopathy in Patients Undergoing Off-Pump Coronary Artery Bypass with Continuation of Preoperative Aspirin.
- Author
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Kusumoto GO, Higashi M, Shigematsu K, and Yamaura K
- Subjects
- Aged, Blood Coagulation Disorders diagnosis, Coronary Artery Disease blood, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Hydroxyethyl Starch Derivatives administration & dosage, Male, Platelet Aggregation Inhibitors administration & dosage, Retrospective Studies, Thrombelastography, Aspirin administration & dosage, Blood Coagulation drug effects, Blood Coagulation Disorders chemically induced, Coronary Artery Bypass, Off-Pump methods, Coronary Artery Disease therapy, Hydroxyethyl Starch Derivatives adverse effects, Preoperative Care methods
- Abstract
Background: We aimed to evaluate the effect of third-generation hydroxyethyl starch (6% HES 130/0.4) on hemostasis and perioperative blood loss in patients undergoing off-pump coronary artery bypass (OPCAB) with continuation of preoperative aspirin., Methods: Forty-nine consecutive patients, who underwent OPCAB at a single institution between November 1, 2014 and March 31, 2016, were included. Coagulation tests, including thromboelastometry and clinical data of all patients, retrospectively were collected from anesthesia and medical records., Results: The total amount of intraoperative crystalloid and HES was 2057.5 ± 771.6 mL (N = 32) and 1090.6 ± 645.0 mL (N = 32), respectively. In the coagulation pathway, the change ratio of fibrinogen concentration, prothrombin time, and fibrinogen thromboelastometry-maximum clot firmness (FIBTEM-MCF) significantly correlated with HES (P < 0.001, P = 0.00131, and P < 0.001, respectively), but not with crystalloid. In the coagulation pathway concerning interaction with platelets, the change ratio of platelet count, extrinsic thromboelastometry-clotting formation time (EXTEM-CFT), and EXTEM-MCF significantly were correlated with HES (P < 0.001, P < 0.001, and P < 0.001, respectively), but not with crystalloid. At chest closure, the hematocrit decreased in a dose-dependent manner with HES (P < 0.001), but not with crystalloid administration. There was an association between the change ratio of hematocrit and EXTEM-MCF (P = 0.00122). However, intra-postoperative blood loss was not correlated with HES 130/0.4 or crystalloid administration., Conclusion: We found that 6% HES 130/0.4 prolonged coagulation testing in a dose-dependent manner due to hemodilution but did not increase blood loss in patients undergoing OPCAB with continuation of preoperative aspirin.
- Published
- 2021
- Full Text
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5. Association between Preoperative Cardiac Left Ventricular Dysfunction and Perioperative Intraaortic Balloon Pump in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery.
- Author
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Kusumoto G, Shigematsu K, Iwashita K, Tominaga K, Totoki T, and Yamaura K
- Subjects
- Aged, Coronary Angiography, Coronary Artery Disease complications, Diastole, Echocardiography, Female, Heart Ventricles physiopathology, Hospital Mortality trends, Humans, Japan epidemiology, Male, Postoperative Period, Retrospective Studies, Risk Factors, Systole, Ventricular Dysfunction, Left complications, Ventricular Dysfunction, Left mortality, Coronary Artery Bypass, Off-Pump methods, Coronary Artery Disease surgery, Coronary Vessels diagnostic imaging, Heart Ventricles diagnostic imaging, Intra-Aortic Balloon Pumping methods, Preoperative Care methods, Ventricular Dysfunction, Left surgery
- Abstract
Background: Prophylactic use of intraaortic balloon pump (IABP) reduces hospital mortality in patients with left ventricular (LV) systolic dysfunction undergoing coronary artery bypass surgery (CABG); however, its association in patients with LV diastolic dysfunction is unclear. This retrospective study investigated the association between preoperative LV function and perioperative use of IABP in patients undergoing off-pump CABG (OPCAB) at a university hospital., Methods: 100 consecutive patients who underwent OPCAB between January 1, 2011 and August 31, 2014 were studied. Preoperative LV function was categorized into four groups based on LV systolic and diastolic function determined with preoperative transthoracic echocardiography. The use of IABP was reviewed from medical records. The Mann-Whitney test, Pearson chi-square test, or Fisher exact test were used., Results: Patients were categorized into the following groups: normal LV function (n = 43), isolated LV systolic dysfunction (n = 13), isolated LV diastolic dysfunction (n = 21), and combined LV systolic and diastolic dysfunction (n = 14). Intraoperative IABP use was significantly more frequent in patients with isolated LV systolic dysfunction, isolated LV diastolic dysfunction, and combined LV systolic and diastolic dysfunction than in those with normal LV function (P < .05). Furthermore, IABP was used more frequently in patients who developed combined LV systolic and diastolic dysfunction postoperatively (P < .05). Conclusion: Not only the presence of preoperative systolic dysfunction but also LV diastolic dysfunction in the presence of normal LV systolic function were associated with increased use of IABP during and after OPCAB.
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- 2017
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- View/download PDF
6. Neurally Mediated Syncope During Cesarean Delivery: A Case Report.
- Author
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Sato S, Nakamori E, Kusumoto G, Shigematsu K, and Yamaura K
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- Adult, Anesthesia, Obstetrical, Anesthesia, Spinal, Cardiopulmonary Resuscitation, Female, Heart Arrest therapy, Humans, Nitroglycerin therapeutic use, Pregnancy, Risk Factors, Bradycardia etiology, Cesarean Section, Heart Arrest etiology, Intraoperative Complications, Pre-Eclampsia surgery, Pressure, Syncope, Vasovagal complications
- Abstract
A 28-year-old woman with preeclampsia at 32 weeks of gestation underwent a cesarean delivery under spinal anesthesia. Administration of nitroglycerin at 200 μg to relax uterine smooth muscles and the application of fundal pressure led to severe bradycardia and loss of consciousness, followed by cardiac arrest. Delivery was completed immediately and recovery was achieved 10 seconds later following cardiopulmonary resuscitation. Neurally mediated syncope was considered the cause of cardiac arrest. Anesthetists should be aware of the potential risk during cesarean delivery following the administration of nitroglycerin, fundal pressure, regional anesthesia, and hypovolemia because of preeclampsia.
- Published
- 2017
- Full Text
- View/download PDF
7. [Cardiac asystole in the postanesthetic care unit: a case report].
- Author
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Sugi Y, Kusumoto G, Higa K, Nitahara K, Shono S, and Katori K
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- Anesthesia, Epidural, Female, Heart Massage, Humans, Recovery Room, Young Adult, Heart Arrest therapy, Postoperative Complications
- Abstract
We report a patient without apparent heart disease who developed asystole postoperatively. A 24-year-old woman was scheduled for acetabulectomy under lumbar epidural anesthesia with intravenous propofol infusion. There was no profound hypotension or arrhythmia during anesthesia and surgery. She complained of nausea 50 minutes after the operation. The ECG showed an abrupt decrease in the heart rate followed by cardiac asystole 30 seconds after the onset of nausea. Prompt cardiac massage resumed the heart beats in eight seconds. There was no neurological deficit.
- Published
- 2013
8. [Surgical treatment of acute cholecystitis].
- Author
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Yamashita Y, Noritomi T, Matsuoka N, Sinya T, Sugi Y, Higa K, Kusumoto G, and Nitahara K
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- Analgesia, Patient-Controlled, Anesthesia, Cholecystectomy, Cholecystectomy, Laparoscopic, Cholecystitis, Acute classification, Cholecystitis, Acute diagnosis, Cholecystitis, Acute pathology, Diagnostic Imaging, Humans, Pain, Postoperative prevention & control, Perioperative Care, Practice Guidelines as Topic, Severity of Illness Index, Time Factors, Cholecystitis, Acute surgery, Emergency Medical Services
- Abstract
Fundamental treatment for acute cholecystitis is cholecystectomy. However, the adoption of a treatment is dependend on degree of a severity of acute cholecystitis in each patient because its degree is influenced by factors such as duration from the onset of symptoms to medical examination. Early laparoscopic cholecystectomy is the preferred procedure for mild acute cholecystitis. Early cholecystectomy is also performed for moderately acute cholecystitis. However, if patients have severe local inflammation (gangrenous and purulent cholecystitis) early gallbladder drainage or open cholecystectomy is indicated. Emergency operation under adequate medical treatment is indicated for a patient with severe local inflammation of the gallbladder, torsion of the gallbladder, emphysematous cholecystitis, gangrenous cholecystitis, and purulent cholecystitis. Pericholecystic abscess, necrosis of the gallbladder wall, and perforation of the gallbladder can be diagnosed accurately by use of imaging diagnosis. The optimal surgical treatment for acute cholecystitis according to grade of severity should be performed referring to imaging findings.
- Published
- 2012
9. [Landmark method and ultrasound-guided method of internal jugular vein puncture: comparison of residents with staffs].
- Author
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Kusumoto G, Sugi Y, Higa K, Shono S, Katori K, and Nitahara K
- Subjects
- Adult, Anesthesia, General, Humans, Ultrasonography, Young Adult, Anesthesiology education, Catheterization methods, Education, Medical, Continuing, Education, Medical, Graduate, Internship and Residency, Jugular Veins
- Abstract
Background: We compared landmark with ultrasound-guided methods of internal jugular vein puncture in residents and staffs., Methods: Seven residents and five staffs practiced internal jugular vein puncture with landmark and ultrasound-guided methods on a manikin for internal jugular vein cannulation. Thereafter, they performed internal jugular vein cannulation on 42 patients., Results: Number of attempts of internal jugular vein cannulation by the residents was significantly lower with ultrasound-guided method than with landmark method. Three internal jugular veins could not be cannulated by residents with landmark method. The common carotid artery was punctured in one case with either method by residents., Conclusions: Residents need more practice of internal jugular vein puncture on a manikin before clinical practice.
- Published
- 2010
10. [Complications of internal jugular vein cannulation under ultrasound guidance: report of three].
- Author
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Kusumoto G, Iwashita K, Higa Y, Katori K, Nitahara K, and Higa K
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- Adult, Aged, 80 and over, Female, Humans, Male, Middle Aged, Ultrasonography, Carotid Artery Injuries etiology, Carotid Artery, Common, Catheterization adverse effects, Catheterization methods, Jugular Veins diagnostic imaging, Wounds, Penetrating etiology
- Abstract
Internal jugular cannulation with ultrasound guidance has been advocated to decrease its complications. However, there can be serious complications by in-experienced physicians in even ultrasound-guided internal jugular vein cannulation. We report three cases of complications associated with ultrasound-guided internal jugular vein cannulation: puncture of the common carotid artery in two patients and pneumothorax in one.
- Published
- 2009
11. [Monitoring of muscle relaxation at the corrugator supercilli muscle in a patient with atrophied upper limbs].
- Author
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Kusumoto G, Nitahara K, Higa K, Sugi Y, Hamada T, and Haraga I
- Subjects
- Arm, Atrophy, Female, Humans, Middle Aged, Facial Muscles physiology, Monitoring, Physiologic methods, Muscle Relaxation physiology
- Abstract
We report a patient whose muscle relaxation was monitored at the corrugator supercilli muscle. In a 51-year-old woman with markedly atrophied upper limbs, anesthesia was induced with propofol and fentanyl. Muscle relaxation was monitored at the adductor pollicis and corrugator supercilli muscles with accelomyography. Train-of-four ratio (TOFR) could be evaluated at the corrugator supercilli muscle; however, it could not be evaluated at the adductor pollicis muscle. The trachea was intubated when the TOFR was 0.09 at the corrugator supercilli muscle after intravenous vecuronium. As the TOFR was 1.44 when the surgery completed, the trachea was extubated without giving neostigmine to antagonize the effect of vecuronium. There was no recurarization after extubation. We conclude that evaluation of TOFR at the corrugator supercilli muscle is useful in some patients who have atrophied adductor pollicis muscle.
- Published
- 2008
12. [Training of internal jugular vein cannulation: comparison of landmark method with ultrasound-guided method].
- Author
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Kusumoto G, Sugi Y, Higa K, Shono S, and Nitahara K
- Subjects
- Manikins, Ultrasonography, Catheterization methods, Jugular Veins diagnostic imaging
- Abstract
We compared training of internal jugular vein cannulation with ultrasound-guided method and that with landmark method in a group of 10 residents and that of 10 staffs. Cannulation was increasingly successful with both methods as the training proceeded, and with increasingly less time and fewer number of punctures. There was no statistically significant difference in time or in number of punctures with ultrasound-guided method between the groups. Ultrasound-guided method needed fewer number of punctures than those with landmark method in both groups.
- Published
- 2008
13. [Pulmonary edema due to upper airway obstruction after extubation].
- Author
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Kusumoto G, Shono S, Nitahara K, Iwakiri S, and Higa K
- Subjects
- Adult, Airway Obstruction therapy, Furosemide administration & dosage, Humans, Infusions, Intravenous, Male, Oxygen Inhalation Therapy, Pulmonary Edema diagnosis, Pulmonary Edema therapy, Airway Obstruction etiology, Intubation, Intratracheal adverse effects, Pulmonary Edema etiology
- Abstract
We report a patient who developed pulmonary edema due to airway obstruction after extubation. A 22-year-old man underwent removal of the nails for thoracoplasty under general anesthesia combined with epidural anesthesia. Upper airway obstruction occurred after extubation. SpO2 decreased to 70%. Insertion of an oral airway relieved the airway obstruction. However, inspiratory wheezing was heard over both lung fields. Chest X-ray taken 90 minutes after the event revealed pulmonary edema. Pulmonary edema gradually resolved after intravenous furosemide and oxygen inhalation by mask.
- Published
- 2006
14. [Anesthetic management of a patient with hepatocellular carcinoma with tumor thrombosis extending into the right atrium].
- Author
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Kusumoto G, Mizukami S, and Higa K
- Subjects
- Carcinoma, Hepatocellular pathology, Cardiopulmonary Bypass, Heart Atria pathology, Hepatectomy, Humans, Liver Neoplasms pathology, Male, Middle Aged, Vena Cava, Inferior pathology, Anesthesia, General methods, Carcinoma, Hepatocellular surgery, Heart Neoplasms pathology, Liver Neoplasms surgery, Neoplastic Cells, Circulating pathology
- Abstract
We report a patient with hepatocellular carcinoma whose tumor thrombus was extending into the right atrium. A 55-year-old man underwent extended anterior segmental hepatectomy and removal of the tumor thrombus in the right atrium under cardiopulmonary bypass and general anesthesia using sevoflurane, nitrous oxide and oxygen. End-tidal carbon dioxide was closely monitored to detect pulmonary tumor emboli during the surgery. Intravenous fluid and blood transfusion in large volumes were necessary to avoid circulatory derangement.
- Published
- 2006
15. [Propofol suppresses the responses in hypoglossal nerve activity to hypercapnic-hypoxic stimulation].
- Author
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Nakamura S, Ohno R, Suzuki M, Abe T, Narita Y, Kusumoto G, Tsuchiya M, Mizumoto H, Murakami Y, Nagasaka H, and Miyata Y
- Subjects
- Animals, Male, Rabbits, Respiration, Anesthetics, Intravenous pharmacology, Hypercapnia physiopathology, Hypoglossal Nerve physiology, Hypoxia physiopathology, Phrenic Nerve physiology, Propofol pharmacology
- Abstract
Background: Upper airway obstruction and inadequate ventilation often arise during sedation and anesthesia by propofol. To estimate the influence of propofol (PP) on respiratory control, we studied its effect on the neural activity and the respiratory response caused by a brief (60 sec) respiratory arrest (RA) manifesting in the hypoglossal nerve (HG) and the phrenic nerve (PN) in rabbits., Methods: Experiments were performed on adult rabbits vagotomized, paralyzed and ventilated artificially with 50% N2O, 50% oxygen and 0.5% sevoflurane. We evaluated and compared the effects of PP on the peak amplitude (AMP) and the root mean square (RMS) of HG and PH, and respiratory cycle (Tc)., Results: PP depressed HG activity more than PH activity, and increased Tc in a dose related manner, with 0.25 mg x kg(-1) x min(-1) continuous infusion, propofol soon began to reduce both AMPs without any remarkable changing in Tc. AMP&RMS-HG were reduced to about 35% and AMP&RMS-PN to 80% of control. Administration of propofol 1.5 mg x kg(-1) x min(-1) vanished the activity of HG in all animals. RA made a mixed hypercapnic and hypoxic condition and induced RA response which was characterized by raised AMPs, augmented RMSs (deltaAMPs, deltaRMSs) in activity of both nerves activity and lengthened Tc (deltaTc). PP depressed RA response in HG dose-dependently, but did not do so in PN. Significant depressions in cardiovascular effects with tested dosage of PP occurred, but the values were kept in physiological ranges., Conclusions: These results suggest that propofol induces respiratory depression by its inhibitory effect on the neural regulation of respiration, especially on the maintenance system of upper airway patency and the reflex related to the chemosensitive upper airway patency control.
- Published
- 2004
16. [Effect of flumazenil on hypoglossal and phrenic nerves activities in rabbits].
- Author
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Nakamura S, Sakamaki H, Suzuki M, Ohno R, Kusumoto G, Terayama K, Nishida M, Hayashi T, Murakami Y, Nagasaka H, and Miyata Y
- Subjects
- Action Potentials drug effects, Animals, Benzodiazepines antagonists & inhibitors, Diazepam pharmacology, Male, Rabbits, Flumazenil pharmacology, Hypoglossal Nerve drug effects, Phrenic Nerve drug effects, Respiration drug effects
- Abstract
Background: Upper airway obstruction and inadequate ventilation often arise during sedation and anesthesia by benzodiazepines (Bz). Flumazenil antagonizes these effects of active benzodiazepines on the central nervous system. To estimate the influence of flumazenil on the endogenous Bz system related respiratory control, we studied the effect of flumazenil and diazepam on the neural activity and the respiratory response caused by a brief (60 sec) respiratory arrest (RA) manifested in the hypoglossal nerve (HG) and the phrenic nerve (PH) activities in rabbits., Methods: Experiments were performed on adult rabbits which were vagotomized, paralyzed and artificially ventilated with 50% N2O, 50% oxygen and 0.5% sevoflurane. We evaluated and compared the effects of the sequential administrations of flumazenil and diazepam on the peak amplitude (AMP) as well as the root mean square (RMS) of HG and PH, and respiratory cycle (Tc)., Results: Flumazenil by itself increased HG activity more than PH activity with no influence on Tc. But it was not dose-related. Previous administration of flumazenil in total dose of 0.25 mg x kg(-1) could not prevent the anticipated respiratory depression caused by diazepam 2.0 mg x kg(-1). These depressions are greater in HG activity than in PH activity. Additional flumazenil 0.15 mg x kg(-1) following the administration of diazepam promptly reversed these inhibitory effects on HG activity beyond the control level. The same dose of flumazenil, however, did not reverse PH activity sufficiently. RA response was characterized by raised AMPs and augmented RMSs (deltaAMPs, deltaRMSs) with marked prolongation in Tc (deltaTc). Flumazenil and diazepam did not seem to have any influence upon these RA responses. There was a significant change in cardiovascular parameters with the tested dosages of flumazenil and diazepam, but the change was in the normal physiological range., Conclusions: These results suggest the possibility that the endogenous benzodiazepine system is likely to play an inhibitory role in the regulation of respiration, especially in the maintenance of upper airway patency but the system is unrelated to the chemosensitive-respiratory control.
- Published
- 2004
17. [How do diazepam and flumazenil influence respiratory control by the activities of both hypoglossal and phrenic nerves in rabbits?].
- Author
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Hayashi T, Nakamura S, Ohno R, Kusumoto G, Terayama K, Murakami Y, Suzuki M, Nagasaka H, Miyata Y, and Matsumoto I
- Subjects
- Action Potentials drug effects, Animals, Diazepam adverse effects, Diazepam antagonists & inhibitors, Rabbits, Receptors, GABA-A physiology, Diazepam pharmacology, Flumazenil pharmacology, Hypoglossal Nerve drug effects, Phrenic Nerve drug effects, Respiration drug effects
- Abstract
Background: Upper airway obstruction and inadequate ventilation often arise during sedation and anesthesia by benzodiazepines. To estimate the influence of benzodiazepines on the respiratory control, we studied the effect of diazepam and flumazenil on the neural activity and the respiratory response caused by a brief (60 sec) respiratory arrest (RA) observed in the hypoglossal nerve (HG) and phrenic nerve (PH) in rabbits., Methods: Experiments were preformed on adult rabbits vagotomized, paralyzed and ventilated artificially with 50% N2O, 50% oxygen and 0.3-0.5% sevoflurane. We evaluated and compared the effects of diazepam and flumazenil on the peak amplitude (AMP-HG&PH) and the root mean square (RMS-HG&PH) of HG and PH, and respiratory cycle (Tc)., Results: Diazepam depressed HG activity more than PH activity with no influence on Tc. But it did not cause dose-related depression. Flumazenil 0.2 mg.kg-1 completely reversed the respiratory depressions caused by diazepam with the increased Tc. In addition to augmentation of the hypoglossal activity in inspiration, flumazenil caused a rise in its activity in pan-expiratory period in some cases. Additional administration of diazepam 6 mg.kg-1 following flumazenil depressed PH activity again, but did not affect HG activity any more. There was no significant depression in cardiovascular parameters with tested dosages of diazepam and flumazenil. RA response was characterized by raised AMPs and augmented RMSs (delta AMPs, delta RMSs) with marked prolongation in Tc (delta Tc). Diazepam depressed RA response dose dependently, but flumazenil did not seem to antagonize this depression., Conclusions: These results suggest that 1) flumazenil is not only a specific antagonist of benzodiazepines but also a potential excitatory agent of hypoglossal nerve activity, and that 2) there is some functional diversity in disposition of benzodiazepine-receptor binding GABAA-receptor responsible for neural respiratory control system.
- Published
- 2003
18. Combination chemotherapy with risk factor-adjusted dose attenuation for high-risk myelodysplastic syndrome and resulting leukemia in the multicenter study of the Japan Adult Leukemia Study Group (JALSG): results of an interim analysis.
- Author
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Okamoto T, Kanamaru A, Shimazaki C, Motoji T, Takemoto Y, Takahashi M, Fukushima T, Takeshita A, Kusumoto GS, Kishimoto Y, Yorimitsu S, Tsukuda K, Uike N, Arima N, and Ohno R
- Subjects
- Acute Disease, Adult, Age Factors, Aged, Antineoplastic Combined Chemotherapy Protocols toxicity, Bone Marrow pathology, Cytarabine administration & dosage, Cytarabine toxicity, Female, Humans, Idarubicin administration & dosage, Idarubicin toxicity, Japan epidemiology, Karyotyping, Leukemia, Myeloid mortality, Male, Middle Aged, Myelodysplastic Syndromes mortality, Remission Induction methods, Risk Factors, Survival Rate, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Leukemia, Myeloid drug therapy, Myelodysplastic Syndromes drug therapy
- Abstract
Forty-nine adult patients with high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia that progressed from MDS were registered for the multicenter study of the Japan Adult Leukemia Study Group. Forty-three patients were evaluable for the analysis. Idarubicin 12 mg/m2 per day for 3 days and continuous cytosine arabinoside 100 mg/m2 per day for 7 days were given as induction therapy, followed by postremission chemotherapy after complete remission (CR). Because elderly patients and those with hypoplastic marrow usually have complications after intensive chemotherapy, often causing early death, the treatment dose was reduced to 60% or 80% according to the presence of 3 risk factors: age 60 years or older, performance status 2 or more, or presence of hypoplastic bone marrow. Of the 43 evaluable patients (median age, 58 years), 26 (60%) achieved CR. Two patients (5%) died within 2 months of completion of induction therapy. The CR rates for patients treated with 100%, 80%, and 60% of the chemotherapy dose were 55% (12 of 22), 63% (10 of 16), and 80% (4 of 5), respectively, indicating that the risk factor-adjusted dose attenuation was appropriately applied to those who might have had problems with the original dose, thus reducing regimen-related mortality rate. The median overall survival of the 43 patients was 8 months.
- Published
- 2000
19. Long-dormant invasive mole associated with multiple malignancies.
- Author
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Sato H, Matsuda M, Ikuta M, Hada Y, Kusumoto G, and Kirimoto K
- Subjects
- Aged, Buttocks, Carcinoma, Squamous Cell radiotherapy, Endometrium pathology, Female, Humans, Pregnancy, Uterine Cervical Neoplasms radiotherapy, Uterus pathology, Adenocarcinoma pathology, Carcinoma, Squamous Cell pathology, Hydatidiform Mole, Invasive pathology, Neoplasms, Multiple Primary pathology, Osteosarcoma pathology, Stomach Neoplasms pathology, Uterine Cervical Neoplasms pathology, Uterine Neoplasms pathology
- Abstract
A 65-year-old previously healthy housewife, gravida 3, para 3, was first diagnosed as Stage Ib carcinoma of the uterine cervix (poorly differentiated squamous cell carcinoma) and admitted. The external radiation of 5400 rad by telecobalt source was performed. No intracavitary radiation was added. After about 7 1/2 years the patient noticed a tumor of fist size on her buttocks, but she did not present in our clinic regularly. Because of enlarging tumor and general malaise she was readmitted a year later. On the fifth hospital day she died with ileus. Autopsy revealed osteosarcoma of buttocks in the radiation field, stomach cancer (tubular adenocarcinoma) with perforated peritonitis, and invasive mole of the uterine corpus. The patient's last pregnancy terminated as a full-term delivery at 26 years of age and she was 43 years at her menopause. The dormant period of invasive mole was 47 years after her last pregnancy, 30 years after her menopause, and at least 8 years after pelvic radiation.
- Published
- 1985
- Full Text
- View/download PDF
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