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377 results on '"Kuniss, Malte"'

1. Correction: Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study

Author

Metzner, Andreas, Straube, Florian, Tilz, Roland R., Kuniss, Malte, Noelker, Georg, Tebbenjohanns, Juergen, Andresen, Dietrich, Wieneke, Heinrich, Stellbrink, Christoph, Franke, Jennifer, Dorwarth, Uwe, Carion, Phuong Lien, Holbrook, Reece, Hochadel, Matthias, Senges, Jochen, Hoffmann, Ellen, and Kuck, Karl-Heinz

Published
2023
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2. Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study

Author

Metzner, Andreas, Straube, Florian, Tilz, Roland R., Kuniss, Malte, Noelker, Georg, Tebbenjohanns, Juergen, Andresen, Dietrich, Wieneke, Heinrich, Stellbrink, Christoph, Franke, Jennifer, Dorwarth, Uwe, Carion, Phuong Lien, Holbrook, Reece, Hochadel, Matthias, Senges, Jochen, Hoffmann, Ellen, and Kuck, Karl-Heinz

Published
2023
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5. Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Author

Abban, Dzifa Wosornu, Abdul, Nasser, Abud, Atilio Marcelo, Adams, Fran, Addala, Srinivas, Adragão, Pedro, Ageno, Walter, Aggarwal, Rajesh, Agosti, Sergio, Agostoni, Piergiuseppe, Aguilar, Francisco, Linares, Julio Aguilar, Aguinaga, Luis, Ahmed, Jameel, Aiello, Allessandro, Ainsworth, Paul, Aiub, Jorge Roberto, Al-Dallow, Raed, Alderson, Lisa, Aldrete Velasco, Jorge Antonio, Alexopoulos, Dimitrios, Manterola, Fernando Alfonso, Aliyar, Pareed, Alonso, David, Alves da Costa, Fernando Augusto, Amado, José, Amara, Walid, Amelot, Mathieu, Amjadi, Nima, Ammirati, Fabrizio, Andrade, Marianna, Andrawis, Nabil, Annoni, Giorgio, Ansalone, Gerardo, Ariani, M.Kevin, Arias, Juan Carlos, Armero, Sébastien, Arora, Chander, Aslam, Muhammad Shakil, Asselman, M., Audouin, Philippe, Augenbraun, Charles, Aydin, S., Ayryanova, Ivaneta, Aziz, Emad, Backes, Luciano Marcelo, Badings, E., Bagni, Ermentina, Baker, Seth H., Bala, Richard, Baldi, Antonio, Bando, Shigenobu, Banerjee, Subhash, Bank, Alan, Esquivias, Gonzalo Barón, Barr, Craig, Bartlett, Maria, Kes, Vanja Basic, Baula, Giovanni, Behrens, Steffen, Bell, Alan, Benedetti, Raffaella, Mazuecos, Juan Benezet, Benhalima, Bouziane, Bergler-Klein, Jutta, Berneau, Jean-Baptiste, Bernstein, Richard A., Berrospi, Percy, Berti, Sergio, Berz, Andrea, Best, Elizabeth, Bettencourt, Paulo, Betzu, Robert, Bhagwat, Ravi, Bhatta, Luna, Biscione, Francesco, Bisignani, Giovanni, Black, Toby, Bloch, Michael J., Bloom, Stephen, Blumberg, Edwin, Bo, Mario, Bøhmer, Ellen, Bollmann, Andreas, Bongiorni, Maria Grazia, Boriani, Giuseppe, Boswijk, D.J., Bott, Jochen, Bottacchi, Edo, Kalan, Marica Bracic, Bradman, Drew, Brautigam, Donald, Breton, Nicolas, Brouwers, P.J.A.M., Browne, Kevin, Cortada, Jordi Bruguera, Bruni, A., Brunschwig, Claude, Buathier, Hervé, Buhl, Aurélie, Bullinga, John, Cabrera, Jose Walter, Caccavo, Alberto, Cai, Shanglang, Caine, Sarah, Calò, Leonardo, Calvi, Valeria, Sánchez, Mauricio Camarillo, Candeias, Rui, Capuano, Vincenzo, Capucci, Alessandro, Caputo, Ronald, Rizo, Tatiana Cárdenas, Cardona, Francisco, Carlos da Costa Darrieux, Francisco, Duarte Vera, Yan Carlos, Carolei, Antonio, Carreño, Susana, Carvalho, Paula, Cary, Susanna, Casu, Gavino, Cavallini, Claudio, Cayla, Guillaume, Celentano, Aldo, Cha, Tae-Joon, Cha, Kwang Soo, Chae, Jei Keon, Chalamidas, Kathrine, Challappa, Krishnan, Chand, Sunil Prakash, Chandrashekar, Harinath, Chartier, Ludovic, Chatterjee, Kausik, Chavez Ayala, Carlos Antero, Cheema, Aamir, Cheema, Amjad, Chen, Lin, Chen, Shih-Ann, Chen, Jyh Hong, Chiang, Fu-Tien, Chiarella, Francesco, Chih-Chan, Lin, Cho, Yong Keun, Choi, Jong-Il, Choi, Dong Ju, Chouinard, Guy, Hoi-Fan Chow, Danny, Chrysos, Dimitrios, Chumakova, Galina, José Roberto, Eduardo Julián, Valenzuela, Chuquiure, Nica, Nicoleta Cindea, Cislowski, David J., Clay, Anthony, Clifford, Piers, Cohen, Andrew, Cohen, Michael, Cohen, Serge, Colivicchi, Furio, Collins, Ronan, Colonna, Paolo, Compton, Steve, Connolly, Derek, Conti, Alberto, Buenostro, Gabriel Contreras, Coodley, Gregg, Cooper, Martin, Coronel, Julian, Corso, Giovanni, Sales, Juan Cosín, Cottin, Yves, Covalesky, John, Cracan, Aurel, Crea, Filippo, Crean, Peter, Crenshaw, James, Cullen, Tina, Darius, Harald, Dary, Patrick, Dascotte, Olivier, Dauber, Ira, Davalos, Vicente, Davies, Ruth, Davis, Gershan, Davy, Jean-Marc, Dayer, Mark, De Biasio, Marzia, De Bonis, Silvana, De Caterina, Raffaele, De Franceschi, Teresiano, de Groot, J.R., De Horta, José, De La Briolle, Axel, Topete, Gilberto de la Pena, Vicenzo de Paola, Angelo Amato, de Souza, Weimar, de Veer, A., De Wolf, Luc, Decoulx, Eric, Deepak, Sasalu, Defaye, Pascal, Del-Carpio Munoz, Freddy, Brkljacic, Diana Delic, Deumite, N. Joseph, Di Legge, Silvia, Diemberger, Igor, Dietz, Denise, Dionísio, Pedro, Dong, Qiang, Rossi dos Santos, Fabio, Dotcheva, Elena, Doukky, Rami, D'Souza, Anthony, Dubrey, Simon, Ducrocq, Xavier, Dupljakov, Dmitry, Duque, Mauricio, Dutta, Dipankar, Duvilla, Nathalie, Duygun, A., Dziewas, Rainer, Eaton, Charles B., Eaves, William, Ebels-Tuinbeek; Clifford Ehrlich, L.A., Eichinger-Hasenauer, Sabine, Eisenberg, Steven J., El Jabali, Adnan, El Shahawy, Mahfouz, Hernandes, Mauro Esteves, Izal, Ana Etxeberria, Evonich, Rudolph, III, Evseeva, Oksana, Ezhov, Andrey, Fahmy, Raed, Fang, Quan, Farsad, Ramin, Fauchier, Laurent, Favale, Stefano, Fayard, Maxime, Fedele, Jose Luis, Fedele, Francesco, Fedorishina, Olga, Fera, Steven R., Gomes Ferreira, Luis Gustavo, Ferreira, Jorge, Ferri, Claudio, Ferrier, Anna, Ferro, Hugo, Finsen, Alexandra, First, Brian, Fischer, Stuart, Fonseca, Catarina, Almeida, Luísa Fonseca, Forman, Steven, Frandsen, Brad, French, William, Friedman, Keith, Friese, Athena, Fruntelata, Ana Gabriela, Fujii, Shigeru, Fumagalli, Stefano, Fundamenski, Marta, Furukawa, Yutaka, Gabelmann, Matthias, Gabra, Nashwa, Gadsbøll, Niels, Galinier, Michel, Gammelgaard, Anders, Ganeshkumar, Priya, Gans, Christopher, Quintana, Antonio Garcia, Gartenlaub, Olivier, Gaspardone, Achille, Genz, Conrad, Georger, Frédéric, Georges, Jean-Louis, Georgeson, Steven, Giedrimas, Evaldas, Gierba, Mariusz, Ortega, Ignacio Gil, Gillespie, Eve, Giniger, Alberto, Giudici, Michael C., Gkotsis, Alexandros, Glotzer, Taya V., Gmehling, Joachim, Gniot, Jacek, Goethals, Peter, Goldbarg, Seth, Goldberg, Ronald, Goldmann, Britta, Golitsyn, Sergey, Gómez, Silvia, Mesa, Juan Gomez, Gonzalez, Vicente Bertomeu, Gonzalez Hermosillo, Jesus Antonio, González López, Víctor Manuel, Gorka, Hervé, Gornick, Charles, Gorog, Diana, Gottipaty, Venkat, Goube, Pascal, Goudevenos, Ioannis, Graham, Brett, Greer, G. Stephen, Gremmler, Uwe, Grena, Paul G., Grond, Martin, Gronda, Edoardo, Grönefeld, Gerian, Gu, Xiang, Torres Torres, Ivett Guadalupe, Guardigli, Gabriele, Guevara, Carolina, Guignier, Alexandre, Gulizia, Michele, Gumbley, Michael, Günther, Albrecht, Ha, Andrew, Hahalis, Georgios, Hakas, Joseph, Hall, Christian, Han, Bing, Han, Seongwook, Hargrove, Joe, Hargroves, David, Harris, Kenneth B., Haruna, Tetsuya, Hayek, Emil, Healey, Jeff, Hearne, Steven, Heffernan, Michael, Heggelund, Geir, Heijmeriks, J.A., Hemels, Maarten, Hendriks, I., Henein, Sam, Her, Sung-Ho, Hermany, Paul, Hernández Del Río, Jorge Eduardo, Higashino, Yorihiko, Hill, Michael, Hisadome, Tetsuo, Hishida, Eiji, Hoffer, Etienne, Hoghton, Matthew, Hong, Kui, Hong, Suk keun, Horbach, Stevie, Horiuchi, Masataka, Hou, Yinglong, Hsing, Jeff, Huang, Chi-Hung, Huckins, David, Hughes, kathy, Huizinga, A., Hulsman, E.L., Hung, Kuo-Chun, Hwang, Gyo-Seung, Ikpoh, Margaret, Imberti, Davide, Ince, Hüseyin, Indolfi, Ciro, Inoue, Shujiro, Irles, Didier, Iseki, Harukazu, Israel, C. Noah, Iteld, Bruce, Iyer, Venkat, Jackson-Voyzey, Ewart, Jaffrani, Naseem, Jäger, Frank, James, Martin, Jang, Sung-Won, Jaramillo, Nicolas, Jarmukli, Nabil, Jeanfreau, Robert J., Jenkins, Ronald D., Sánchez, Carlos Jerjes, Jimenez, Javier, Jobe, Robert, Joen-Jakobsen, Tomas, Jones, Nicholas, Moura Jorge, Jose Carlos, Jouve, Bernard, Jung, Byung Chun, Jung, Kyung Tae, Jung, Werner, Kachkovskiy, Mikhail, Kafkala, Krystallenia, Kalinina, Larisa, Kallmünzer, Bernd, Kamali, Farzan, Kamo, Takehiro, Kampus, Priit, Kashou, Hisham, Kastrup, Andreas, Katsivas, Apostolos, Kaufman, Elizabeth, Kawai, Kazuya, Kawajiri, Kenji, Kazmierski, John F., Keeling, P., Kerr Saraiva, José Francisco, Ketova, Galina, Khaira, Ajit Singh, Khripun, Aleksey, Kim, Doo-Il, Kim, Young Hoon, Kim, Nam Ho, Kim, Dae Kyeong, Kim, Jeong Su, Kim, June Soo, Kim, Ki Seok, Kim, Jin bae, Kinova, Elena, Klein, Alexander, Kmetzo, James J., Kneller, G. Larsen, Knezevic, Aleksandar, Angela Koh, Su Mei, Koide, Shunichi, Kollias, Anastasios, Kooistra, J.A., Koons, Jay, Koschutnik, Martin, Kostis, William J., Kovacic, Dragan, Kowalczyk, Jacek, Koziolova, Natalya, Kraft, Peter, Kragten, Johannes A., Krantz, Mori, Krause, Lars, Krenning, B.J., Krikke, F., Kromhout, Z., Krysiak, Waldemar, Kumar, Priya, Kümler, Thomas, Kuniss, Malte, Kuo, Jen-Yuan, Küppers, Achim, Karla Kurrelmeyer, Kwak, Choong Hwan, Laboulle, Bénédicte, Labovitz, Arthur, Lai, Wen Ter, Lam, Andy, Lam, Yat Yin, Zanetti, Fernando Lanas, Landau, Charles, Landini, Giancarlo, Figueiredo, Estêvão Lanna, Larsen, Torben, Lavandier, Karine, LeBlanc, Jessica, Lee, Moon Hyoung, Lee, Chang-Hoon, Lehman, John, Leitão, Ana, Lellouche, Nicolas, Lelonek, Malgorzata, Lenarczyk, Radoslaw, Lenderink, T., González, Salvador León, Leong-Sit, Peter, Leschke, Matthias, Ley, Nicolas, Li, Zhanquan, Li, Xiaodong, Li, Weihua, Li, Xiaoming, Lichy, Christhoh, Lieber, Ira, Limon Rodriguez, Ramon Horacio, Lin, Hailong, Lip, Gregory Y.H., Liu, Feng, Liu, Hengliang, Esperon, Guillermo Llamas, Navarro, Nassip Llerena, Lo, Eric, Lokshyn, Sergiy, López, Amador, López-Sendón, José Luís, Lorga Filho, Adalberto Menezes, Lorraine, Richard S., Luengas, Carlos Alberto, Luke, Robert, Luo, Ming, Lupovitch, Steven, Lyrer, Philippe, Ma, Changsheng, Ma, Genshan, Madariaga, Irene, Maeno, Koji, Magnin, Dominique, Maid, Gustavo, Mainigi, Sumeet K., Makaritsis, Konstantinos, Malhotra, Rohit, Manning, Rickey, Manolis, Athanasios, Manrique Hurtado, Helard Andres, Mantas, Ioannis, Jattin, Fernando Manzur, Maqueda, Vicky, Marchionni, Niccolo, Ortuno, Francisco Marin, Santana, Antonio Martín, Martinez, Jorge, Maskova, Petra, Hernandez, Norberto Matadamas, Matsuda, Katsuhiro, Maurer, Tillmann, Mauro, Ciro, May, Erik, Mayer, Nolan, McClure, John, McCormack, Terry, McGarity, William, McIntyre, Hugh, McLaurin, Brent, Medina Palomino, Feliz Alvaro, Melandri, Francesco, Meno, Hiroshi, Menzies, Dhananjai, Mercader, Marco, Meyer, Christian, Meyer, Beat J., Miarka, Jacek, Mibach, Frank, Michalski, Dominik, Michel, Patrik, Chreih, Rami Mihail, Mikdadi, Ghiath, Mikus, Milan, Milicic, Davor, Militaru, Constantin, Minaie, Sedi, Minescu, Bogdan, Mintale, Iveta, Mirault, Tristan, Mirro, Michael J., Mistry, Dinesh, Miu, Nicoleta Violeta, Miyamoto, Naomasa, Moccetti, Tiziano, Mohammed, Akber, Nor, Azlisham Mohd, Mollerus, Michael, Molon, Giulio, Mondillo, Sergio, Moniz, Patrícia, Mont, Lluis, Montagud, Vicente, Montaña, Oscar, Monti, Cristina, Moretti, Luciano, Mori, Kiyoo, Moriarty, Andrew, Morka, Jacek, Moschini, Luigi, Moschos, Nikitas, Mügge, Andreas, Mulhearn, Thomas J., Muresan, Carmen, Muriago, Michela, Musial, Wlodzimierz, Musser, Carl W., Musumeci, Francesco, Nageh, Thuraia, Nakagawa, Hidemitsu, Nakamura, Yuichiro, Nakayama, Toru, Nam, Gi-Byoung, Nanna, Michele, Natarajan, Indira, Nayak, Hemal M., Naydenov, Stefan, Nazlić, Jurica, Cristian Nechita, Alexandru, Nechvatal, Libor, Negron, Sandra Adela, Neiman, James, Neuenschwander, Fernando Carvalho, Neves, David, Neykova, Anna, Miguel, Ricardo Nicolás, Nijmeh, George, Nizov, Alexey, Campos, Rodrigo Noronha, Nossan, Janko, Novikova, Tatiana, Nowalany-Kozielska, Ewa, Nsah, Emmanuel, Nunez Fragoso, Juan Carlos, Nurgalieva, Svetlana, Nuyens, Dieter, Nyvad, Ole, Odin de Los Rios Ibarra, Manuel, O'Donnell, Philip, O'Donnell, Martin, Oh, Seil, Oh, Yong Seog, Oh, Dongjin, O'Hara, Gilles, Oikonomou, Kostas, Olivares, Claudia, Oliver, Richard, Ruiz, Rafael Olvera, Olympios, Christoforos, omaszuk-Kazberuk, Anna, Asensi, Joaquín Osca, Jose, eena Padayattil, Padilla Padilla, Francisco Gerardo, Rios, Victoria Padilla, Pajes, Giuseppe, Pandey, Shekhar, Paparella, Gaetano, Paris, F., Park, Hyung Wook, Park, Jong Sung, Parthenakis, Fragkiskos, Passamonti, Enrico, Patel, Rajesh J., Patel, Jaydutt, Patel, Mehool, Patrick, Janice, Jimenez, Ricardo Pavón, Paz, Analía, Pengo, Vittorio, Pentz, William, Pérez, Beatriz, Pérez Ríos, Alma Minerva, Pérez-Cabezas, Alejandro, Perlman, Richard, Persic, Viktor, Perticone, Francesco, Peters, Terri K., Petkar, Sanjiv, Pezo, Luis Felipe, Pflücke, Christian, Pham, David N., Phillips, Roland T., Phlaum, Stephen, Pieters, Denis, Pineau, Julien, Pinter, Arnold, Pinto, Fausto, Pisters, R., Pivac, Nediljko, Pocanic, Darko, Podoleanu, Cristian, Politano, Alessandro, Poljakovic, Zdravka, Pollock, Stewart, Garcéa, Jose Polo, Poppert, Holger, Porcu, Maurizio, Reino, Antonio Pose, Prasad, Neeraj, Précoma, Dalton Bertolim, Prelle, Alessandro, Prodafikas, John, Protasov, Konstantin, Pye, Maurice, Qiu, Zhaohui, Quedillac, Jean-Michel, Raev, Dimitar, Raffo Grado, Carlos Antonio, Rahimi, Sidiqullah, Raisaro, Arturo, Rama, Bhola, Ramos, Ricardo, Ranieri, Maria, Raposo, Nuno, Rashba, Eric, Rauch-Kroehnert, Ursula, Reddy, Ramakota, Renda, Giulia, Reza, Shabbir, Ria, Luigi, Richter, Dimitrios, Rickli, Hans, Rieker, Werner, Vera, Tomas Ripolil, Ritt, Luiz Eduardo, Roberts, Douglas, Briones, Ignacio Rodriguez, Rodriguez Escudero, Aldo Edwin, Pascual, Carlos Rodríguez, Roman, Mark, Romeo, Francesco, Ronner, E., Roux, Jean-Francois, Rozkova, Nadezda, Rubacek, Miroslav, Rubalcava, Frank, Russo, Andrea M., Rutgers, Matthieu Pierre, Rybak, Karin, Said, Samir, Sakamoto, Tamotsu, Salacata, Abraham, Salem, Adrien, Bodes, Rafael Salguero, Saltzman, Marco A., Salvioni, Alessandro, Vallejo, Gregorio Sanchez, Fernández, Marcelo Sanmartín, Saporito, Wladmir Faustino, Sarikonda, Kesari, Sasaoka, Taishi, Sati, Hamdi, Savelieva, Irina, Scala, Pierre-Jean, Schellinger, Peter, Scherr, Carlos, Schmitz, Lisa, Schmitz, Karl-Heinz, Schmitz, Bettina, Schnabel, Teresa, Schnupp, Steffen, Schoeniger, Peter, Schön, Norbert, Schwimmbeck, Peter, Seamark, Clare, Searles, Greg, Seidl, Karl-Heinz, Seidman, Barry, Sek, Jaroslaw, Sekaran, Lakshmanan, Serrati, Carlo, Shah, Neerav, Shah, Vinay, Shah, Anil, Shah, Shujahat, Sharma, Vijay Kumar, Shaw, Louise, Sheikh, Khalid H., Shimizu, Naruhito, Shimomura, Hideki, Shin, Dong-Gu, Shin, Eun-Seok, Shite, Junya, Sibilio, Gerolamo, Silver, Frank, Sime, Iveta, Simmers, Tim A., Singh, Narendra, Siostrzonek, Peter, Smadja, Didier, Smith, David W., Snitman, Marcelo, Filho, Dario Sobral, Soda, Hassan, Sofley, Carl, Sokal, Adam, Oi Yan, Yannie Soo, Sotolongo, Rodolfo, Ferreira de Souza, Olga, Sparby, Jon Arne, Spinar, Jindrich, Sprigings, David, Spyropoulos, Alex C., Stakos, Dimitrios, Steinwender, Clemens, Stergiou, Georgios, Stiell, Ian, Stoddard, Marcus, Stoikov, Anastas, Streb, Witold, Styliadis, Ioannis, Su, Guohai, Su, Xi, Sudnik, Wanda, Sukles, Kai, Sun, Xiaofei, Swart, H., Szavits-Nossan, Janko, Taggeselle, Jens, Takagi, Yuichiro, Singh Takhar, Amrit Pal, Tamm, Angelika, Tanaka, Katsumi, Tanawuttiwat, Tanyanan, Tang, Sherman, Tang, Aylmer, Tarsi, Giovanni, Tassinari, Tiziana, Tayal, Ashis, Tayebjee, Muzahir, Berg, J.M. ten, Tesloianu, Dan, The, Salem H.K., Thomas, Dierk, Timsit, Serge, Tobaru, Tetsuya, Tomasik, Andrzej R., Torosoff, Mikhail, Touze, Emmanuel, Trendafilova, Elina, Tsai, W. Kevin, Tse, Hung Fat, Tsutsui, Hiroshi, Tu, Tian Ming, Tuininga, Ype, Turakhia, Minang, Turk, Samir, Turner, Wayne, Tveit, Arnljot, Tytus, Richard, Valadão, C., van Bergen, P.F.M.M., van de Borne, Philippe, van den Berg, B.J., van der Zwaan, C., Van Eck, M., Vanacker, Peter, Vasilev, Dimo, Vasilikos, Vasileios, Vasilyev, Maxim, Veerareddy, Srikar, Miño; Asok Venkataraman, Mario Vega, Verdecchia, Paolo, Versaci, Francesco, Vester, Ernst Günter, Vial, Hubert, Victory, Jason, Villamil, Alejandro, Vincent, Marc, Vlastaris, Anthony, Dahl, Jürgen vom, Vora, Kishor, Vranian, Robert B., Wakefield, Paul, Wang, Ningfu, Wang, Mingsheng, Wang, Xinhua, Wang, Feng, Wang, Tian, Warner, Alberta L., Watanabe, Kouki, Wei, Jeanne, Weimar, Christian, Weiner, Stanislav, Weinrich, Renate, Wen, Ming-Shien, Wiemer, Marcus, Wiggers, Preben, Wilke, Andreas, Williams, David, Williams, Marcus L., Witzenbichler, Bernhard, Wong, Brian, Lawrence Wong, Ka Sing, Wozakowska-Kaplon, Beata, Wu, Shulin, Wu, Richard C., Wunderlich, Silke, Wyatt, Nell, Wylie, John (Jack), Xu, Yong, Xu, Xiangdong, Yamanoue, Hiroki, Yamashita, Takeshi, Bryan Yan, Ping Yen, Yang, Tianlun, Yao, Jing, Yeh, Kuo-Ho, Yin, Wei Hsian, Yotov, Yoto, Zahn, Ralf, Zarich, Stuart, Zenin, Sergei, Zeuthen, Elisabeth Louise, Zhang, Huanyi, Zhang, Donghui, Zhang, Xingwei, Zhang, Ping, Zhang, Jun, Zhao, Shui Ping, Zhao, Yujie, Zhao, Zhichen, Zheng, Yang, Zhou, Jing, Zimmermann, Sergio, Zini, Andrea, Zizzo, Steven, Zong, Wenxia, Zukerman, L. Steven, Romiti, Giulio Francesco, Corica, Bernadette, Proietti, Marco, Mei, Davide Antonio, Frydenlund, Juliane, Bisson, Arnaud, Olshansky, Brian, Chan, Yi-Hsin, Huisman, Menno V., and Chao, Tze-Fan

Published
2023
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6. Expert opinion on design and endpoints for studies on catheter ablation of atrial fibrillation.

Author

Lewalter, Thorsten, Blomström‐Lundqvist, Carina, Lakkireddy, Dhanunjaya, Packer, Douglas, Meyer, Ralf, Kuniss, Malte, Ladwig, Karl‐H., Jilek, Clemens, Diener, Hans‐C., Boriani, Giuseppe, Turakhia, Mintu P., Schneider, Steffen, Svennberg, Emma, Albers, Bert, Andrade, Jason G., de Melis, Mirko, and Brachmann, Johannes

Subjects
MEDICAL protocols, DOCUMENTATION, PATIENT selection, RESEARCH funding, MEDICAL personnel, ABLATION techniques, CLINICAL trials, RESEARCH evaluation, EXPERIMENTAL design, ARRHYTHMIA, DISCUSSION, ATRIAL fibrillation, RESEARCH methodology, CATHETER ablation, EXPERTISE
Abstract

Introduction: Catheter ablation of atrial fibrillation (AF) is frequently studied in randomized trials, observational and registry studies. The aim of this expert opinion is to provide guidance for clinicians and industry regarding the development of future clinical studies on catheter ablation of AF, implement lessons learned from previous studies, and promote a higher degree of consistency across studies. Background: Studies on catheter ablation of AF may benefit from well‐described definitions of endpoints and consistent methodology and documentation of outcomes related to efficacy, safety and cost‐effectiveness. The availably of new, innovative technologies warrants further consideration about their application and impact on study design and the choice of endpoints. Moreover, recent insights gained from AF ablation studies suggest a reconsideration of some methodological aspects. Methods: A panel of clinical experts on catheter ablation of AF and designing and conducting clinical studies developed an expert opinion on the design and endpoints for studies on catheter ablation of AF. Discussions within the expert panel with the aim to reach consensus on predefined topics were based on outcomes reported in the literature and experiences from recent clinical trials. Results: A comprehensive set of recommendations is presented. Key elements include the documentation of clinical AF, medication during the study, repeated ablations and their effect on endpoint assessments, postablation blanking and the choice of rhythm‐related and other endpoints. Conclusion: This expert opinion provides guidance and promotes consistency regarding design of AF catheter ablation studies and identified aspects requiring further research to optimize study design and methodology. Recent insights from studies on catheter ablation of atrial fibrillation (AF) and the availability of new innovative technologies warrant reconsideration of methodological aspects related to study design and the choice and assessment of endpoints. This expert opinion, developed by clinical experts on catheter ablation of AF provides a comprehensive set of recommendations related to these methodological aspects. The aim of this expert opinion is to provide guidance for clinicians and industry regarding the development of clinical studies, implement lessons learned from previous studies, and promote a higher degree of consistency across studies. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Initial rhythm control with cryoballoon ablation vs drug therapy: Impact on quality of life and symptoms

Author

Pavlovic, Nikola, Chierchia, Gian-Battista, Velagic, Vedran, Hermida, Jean Sylvain, Healey, Stewart, Arena, Giuseppe, Badenco, Nicolas, Meyer, Christian, Chen, Jian, Iacopino, Saverio, Anselme, Frédéric, Dekker, Lukas, Scazzuso, Fernando, Packer, Douglas L, de Asmundis, Carlo, Pitschner, Heinz-Friedrich, Piazza, Fabio Di, Kaplon, Rachelle E, and Kuniss, Malte

Published
2021
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10. A danish healthcare-focused economic evaluation of first-line cryoballoon ablation versus antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation.

Author

Hansen, Morten Lock, Moss, Joe W. E., Tønnesen, Jacob, Johansen, Mette Lundsby, Kuniss, Malte, Ismyrloglou, Eleni, Andrade, Jason, Wazni, Oussama, Mealing, Stuart, Sale, Alicia, Afonso, Daniela, Bromilow, Tom, Lane, Emily, and Chierchia, Gian Battista

Subjects
ATRIAL fibrillation, MYOCARDIAL depressants, DRUG therapy, QUALITY-adjusted life years, QUALITY of life
Abstract

Introduction: Three randomised controlled trials (RCTs) have demonstrated that first-line cryoballoon pulmonary vein isolation decreases atrial tachycardia in patients with symptomatic paroxysmal atrial fibrillation (PAF) compared with antiarrhythmic drugs (AADs). The aim of this study was to develop a cost-effectiveness model (CEM) for first-line cryoablation compared with first-line AADs for the treatment of PAF. The model used a Danish healthcare perspective. Methods: Individual patient-level data from the Cryo-FIRST, STOP AF and EARLY-AF RCTs were used to parameterise the CEM. The model structure consisted of a hybrid decision tree (one-year time horizon) and a Markov model (40-year time horizon, with a three-month cycle length). Health-related quality of life was expressed in quality-adjusted life years (QALYs). Costs and benefits were discounted at 3% per year. Model outcomes were produced using probabilistic sensitivity analysis. Results: First-line cryoablation is dominant, meaning it results in lower costs (-€2,663) and more QALYs (0.18) when compared to first-line AADs. First-line cryoablation also has a 99.96% probability of being cost-effective, at a cost-effectiveness threshold of €23,200 per QALY gained. Regardless of initial treatment, patients were expected to receive ∼ 1.2 ablation procedures over a lifetime horizon. Conclusion: First-line cryoablation is both more effective and less costly (i.e. dominant), when compared with AADs for patients with symptomatic PAF in a Danish healthcare system. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Pulmonary Vein Isolation Followed by Biatrial Ablation of Rotational Activity in Patients with Persistent Atrial Fibrillation: Results of the Cryo-Vest Study

Author

Weipert, Kay Felix, primary, Hutter, Julie, additional, Kuniss, Malte, additional, Kahle, Patrick, additional, Yogarajah, Joerg, additional, Hain, Andreas, additional, Sperzel, Johannes, additional, Berkowitsch, Alexander, additional, Hamm, Christian W., additional, and Neumann, Thomas, additional

Published
2024
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14. Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry

Author

Heeger, Christian-H., Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R., El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M., Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K.R., Aytemir, Kudret, Jędrzejczyk-Patej, Ewa, Kuck, Karl-Heinz, Dahme, Tillman, Steven, Daniel, Sommer, Philipp, and Richard Tilz, Roland

Published
2022
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15. The Cost-Effectiveness of First-Line Cryoablation versus First-Line Antiarrhythmic Drugs in Canadian Patients with Paroxysmal Atrial Fibrillation

Author

Andrade, Jason G., primary, Moss, Joe W.E., additional, Kuniss, Malte, additional, Sadri, Hamid, additional, Wazni, D. Oussama, additional, Sale, Alicia, additional, Ismyrloglou, Eleni, additional, Chierchia, Gian Battista, additional, Kaplon, Rachelle, additional, Mealing, Stuart, additional, Bainbridge, Jamie, additional, Bromilow, Tom, additional, Lane, Emily, additional, and Khaykin, Yaariv, additional

Published
2023
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24. A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study

Author

Tilz, Roland Richard, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe, Chun, Kr Julian, Martinek, Martin, Sohns, Christian, Schmidt, Boris, Mandel, Franck, Gandjbakhch, Estelle, Laredo, Mikael, Gunawardene, Melanie Anuscha, Willems, Stephan, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Grosse Meininghaus, Dirk, Foresti, Mike, Bonsels, Marc, Reek, David, Wiegand, Uwe, Bauer, Alexander, Metzner, Andreas, Eckardt, Lars, Popescu, Sorin Ștefan, Krahnefeld, Olaf, Sticherling, Christian, Kühne, Michael, Nguyen, Dinh Quang, Roten, Laurent, Saguner, Ardan M, Linz, Dominik, van der Voort, Pepijn, Mulder, Bart A, Vijgen, Johan, Almorad, Alexandre, Guenancia, Charles, Fauchier, Laurent, Boveda, Serge, De Greef, Y, Da Costa, Antoine, Jais, Pierre, Derval, Nicolas, Milhem, Antoine, Jesel, Laurence, Garcia, Rodrigue, Poty, Hervé, Khoueiry, Ziad, Seitz, Julien, Laborderie, Julien, Mechulan, Alexis, Brigadeau, Francois, Zhao, Alexandre, Saludas, Yannick, Piot, Olivier, Ahluwalia, Nikhil, Martin, Claire, Chen, Jian, Antolic, Bor, Leventopoulos, Georgios, Özcan, Emin Evren, Yorgun, Hikmet, Cay, Serkan, Yalin, Kivanc, Botros, Maichel Sobhy, Mahmoud, Ahmed Taher, Jędrzejczyk-Patej, Ewa, Inaba, Osamu, Okumura, Ken, Ejima, Koichiro, Khakpour, Houman, Boyle, Noel, Catanzaro, J N, Reddy, Vivek, Mohanty, Sanghamitra, Natale, Andrea, Blessberger, Hermann, Yang, Bing, Stevens, Irene, Sommer, Philipp, Veltmann, Christian, Steven, Daniel, Vogler, Julia, Kuck, Karl-Heinz, Merino, José Luis, Keelani, Ahmad, and Heeger, Christian-H

Subjects
610 Medicine & health, ddc:610, Cardiology and Cardiovascular Medicine
Abstract

Aims Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. Methods and results This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 centres 138 patients [0.025%, radiofrequency: 0.038%, cryoballoon: 0.0015% (P < 0.0001)] were diagnosed with an oesophageal fistula. Peri-procedural data were available for 118 patients (85.5%). Following catheter ablation, the median time to symptoms and the median time to diagnosis were 18 (7.75, 25; range: 0–60) days and 21 (15, 29.5; range: 2–63) days, respectively. The median time from symptom onset to oesophageal fistula diagnosis was 3 (1, 9; range: 0–42) days. The most common initial symptom was fever (59.3%). The diagnosis was established by chest computed tomography in 80.2% of patients. Oesophageal surgery was performed in 47.4% and direct endoscopic treatment in 19.8% and conservative treatment in 32.8% of patients. The overall mortality was 65.8%. Mortality following surgical (51.9%) or endoscopic treatment (56.5%) was significantly lower as compared to conservative management (89.5%) [odds ratio 7.463 (2.414, 23.072) P < 0.001]. Conclusion Oesophageal fistula after catheter ablation of atrial fibrillation is rare and occurs mostly with the use of radiofrequency energy rather than cryoenergy. Mortality without surgical or endoscopic intervention is exceedingly high.

Published
2023

26. PO-02-006 AN ECONOMIC EVALUATION OF FIRST-LINE CRYOBALLOON ABLATION VERSUS ANTIARRHYTHMIC DRUG THERAPY FOR THE TREATMENT OF PAROXYSMAL ATRIAL FIBRILLATION FROM A UNITED STATES MEDICARE PERSPECTIVE

Author

Wazni, Oussama M., primary, Moss, Joe, additional, Kuniss, Malte, additional, Andrade, Jason G., additional, Chierchia, Gian B., additional, Mealing, Stuart, additional, mburu, waruiru, additional, Sale, Alicia, additional, Kaplon, Rachelle, additional, Ismyrloglou, Eleni, additional, Bromilow, Tom, additional, Lane, Emily, additional, Lewis, Damian, additional, and Reynolds, Matthew R., additional

Published
2023
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27. A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study

Author

Tilz, Roland Richard, primary, Schmidt, Vanessa, additional, Pürerfellner, Helmut, additional, Maury, Philippe, additional, Chun, K R J ulian, additional, Martinek, Martin, additional, Sohns, Christian, additional, Schmidt, Boris, additional, Mandel, Franck, additional, Gandjbakhch, Estelle, additional, Laredo, Mikael, additional, Gunawardene, Melanie Anuscha, additional, Willems, Stephan, additional, Beiert, Thomas, additional, Borlich, Martin, additional, Iden, Leon, additional, Füting, Anna, additional, Spittler, Raphael, additional, Gaspar, Thomas, additional, Richter, Sergio, additional, Schade, Anja, additional, Kuniss, Malte, additional, Neumann, Thomas, additional, Francke, Alexander, additional, Wunderlich, Carsten, additional, Shin, Dong-In, additional, Meininghaus, Dirk Grosse, additional, Foresti, Mike, additional, Bonsels, Marc, additional, Reek, David, additional, Wiegand, Uwe, additional, Bauer, Alexander, additional, Metzner, Andreas, additional, Eckardt, Lars, additional, Popescu, Sorin Ștefan, additional, Krahnefeld, Olaf, additional, Sticherling, Christian, additional, Kühne, Michael, additional, Nguyen, Dinh Quang, additional, Roten, Laurent, additional, Saguner, Ardan M, additional, Linz, Dominik, additional, van der Voort, Pepijn, additional, Mulder, Bart A, additional, Vijgen, Johan, additional, Almorad, Alexandre, additional, Guenancia, Charles, additional, Fauchier, Laurent, additional, Boveda, Serge, additional, Greef, Y De, additional, Da Costa, Antoine, additional, Jais, Pierre, additional, Derval, Nicolas, additional, Milhem, Antoine, additional, Jesel, Laurence, additional, Garcia, Rodrigue, additional, Poty, Hervé, additional, Khoueiry, Ziad, additional, Seitz, Julien, additional, Laborderie, Julien, additional, Mechulan, Alexis, additional, Brigadeau, Francois, additional, Zhao, Alexandre, additional, Saludas, Yannick, additional, Piot, Olivier, additional, Ahluwalia, Nikhil, additional, Martin, Claire, additional, Chen, Jian, additional, Antolic, Bor, additional, Leventopoulos, Georgios, additional, Özcan, Emin Evren, additional, Yorgun, Hikmet, additional, Cay, Serkan, additional, Yalin, Kivanc, additional, Botros, Maichel Sobhy, additional, Mahmoud, Ahmed Taher, additional, Jędrzejczyk-Patej, Ewa, additional, Inaba, Osamu, additional, Okumura, Ken, additional, Ejima, Koichiro, additional, Khakpour, Houman, additional, Boyle, Noel, additional, Catanzaro, John N, additional, Reddy, Vivek, additional, Mohanty, Sanghamitra, additional, Natale, Andrea, additional, Blessberger, Hermann, additional, Yang, Bing, additional, Stevens, Irene, additional, Sommer, Philipp, additional, Veltmann, Christian, additional, Steven, Daniel, additional, Vogler, Julia, additional, Kuck, Karl-Heinz, additional, Merino, José Luis, additional, Keelani, Ahmad, additional, and Heeger, Christian-H, additional

Published
2023
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29. Impact of cryoballoon application abortion due to phrenic nerve injury on reconnection rates: a YETI subgroup analysis

Author

Heeger, Christian-H, Popescu, Sorin Stefan, Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R., El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M., Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K. R., Aytemir, Kudret, Jedrzejczyk-Patej, Ewa, Kuck, Karl-Heinz, Dahme, Tillman, Steven, Daniel, Sommer, Philipp, Tilz, Roland Richard, Heeger, Christian-H, Popescu, Sorin Stefan, Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R., El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M., Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K. R., Aytemir, Kudret, Jedrzejczyk-Patej, Ewa, Kuck, Karl-Heinz, Dahme, Tillman, Steven, Daniel, Sommer, Philipp, and Tilz, Roland Richard

Abstract

Aims Cryoballoon (CB)-based pulmonary vein isolation (PVI) is an effective treatment for atrial fibrillation (AF). The most frequent complication during CB-based PVI is right-sided phrenic nerve injury (PNI) which is leading to premature abortion of the freeze cycle. Here, we analysed reconnection rates after CB-based PVI and PNI in a large-scale population during repeat procedures. Methods and results In the YETI registry, a total of 17 356 patients underwent CB-based PVI in 33 centres, and 731 (4.2%) patients experienced PNI. A total of 111/731 (15.2%) patients received a repeat procedure for treatment of recurrent AF. In 94/111 (84.7%) patients data on repeat procedures were available. A total of 89/94 (94.7%) index pulmonary veins (PVs) have been isolated during the initial PVI. During repeat procedures, 22 (24.7%) of initially isolated index PVs showed reconnection. The use of a double stop technique did non influence the PV reconnection rate (P = 0.464). The time to PNI was 140.5 +/- 45.1 s in patients with persistent PVI and 133.5 +/- 53.8 s in patients with reconnection (P = 0.559). No differences were noted between the two populations in terms of CB temperature at the time of PNI (P = 0.362). The only parameter associated with isolation durability was CB temperature after 30 s of freezing. The PV reconnection did not influence the time to AF recurrence. Conclusion In patients with cryoballon application abortion due to PNI, a high rate of persistent PVI rate was found at repeat procedures. Our data may help to identify the optimal dosing protocol in CB-based PVI procedures.

Published
2023

30. A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study

Author

Tilz, Roland Richard; https://orcid.org/0000-0002-0122-7130, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe; https://orcid.org/0000-0002-4800-1841, Chun, K R Julian, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Schmidt, Boris; https://orcid.org/0000-0001-5347-9906, Mandel, Franck, Gandjbakhch, Estelle; https://orcid.org/0000-0002-4846-5021, Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Gunawardene, Melanie Anuscha, Willems, Stephan; https://orcid.org/0000-0002-8890-5749, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Meininghaus, Dirk Grosse; https://orcid.org/0000-0003-1532-1934, Foresti, Mike, Bonsels, Marc, Reek, David, et al, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Tilz, Roland Richard; https://orcid.org/0000-0002-0122-7130, Schmidt, Vanessa, Pürerfellner, Helmut, Maury, Philippe; https://orcid.org/0000-0002-4800-1841, Chun, K R Julian, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Schmidt, Boris; https://orcid.org/0000-0001-5347-9906, Mandel, Franck, Gandjbakhch, Estelle; https://orcid.org/0000-0002-4846-5021, Laredo, Mikael; https://orcid.org/0000-0002-7326-2656, Gunawardene, Melanie Anuscha, Willems, Stephan; https://orcid.org/0000-0002-8890-5749, Beiert, Thomas, Borlich, Martin, Iden, Leon, Füting, Anna, Spittler, Raphael, Gaspar, Thomas, Richter, Sergio, Schade, Anja, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Neumann, Thomas, Francke, Alexander, Wunderlich, Carsten, Shin, Dong-In, Meininghaus, Dirk Grosse; https://orcid.org/0000-0003-1532-1934, Foresti, Mike, Bonsels, Marc, Reek, David, et al, and Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803

Abstract

AIMS Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. METHODS AND RESULTS This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 centres 138 patients [0.025%, radiofrequency: 0.038%, cryoballoon: 0.0015% (P < 0.0001)] were diagnosed with an oesophageal fistula. Peri-procedural data were available for 118 patients (85.5%). Following catheter ablation, the median time to symptoms and the median time to diagnosis were 18 (7.75, 25; range: 0-60) days and 21 (15, 29.5; range: 2-63) days, respectively. The median time from symptom onset to oesophageal fistula diagnosis was 3 (1, 9; range: 0-42) days. The most common initial symptom was fever (59.3%). The diagnosis was established by chest computed tomography in 80.2% of patients. Oesophageal surgery was performed in 47.4% and direct endoscopic treatment in 19.8% and conservative treatment in 32.8% of patients. The overall mortality was 65.8%. Mortality following surgical (51.9%) or endoscopic treatment (56.5%) was significantly lower as compared to conservative management (89.5%) [odds ratio 7.463 (2.414, 23.072) P < 0.001]. CONCLUSION Oesophageal fistula after catheter ablation of atrial fibrillation is rare and occurs mostly with the use of radiofrequency energy rather than cryoenergy. Mortality without surgical or endoscopic intervention is exceedingly high.

Published
2023

31. Impact of intracardiac echocardiography usage on the safety of cryoballoon atrial fibrillation ablation: Subanalysis of the prospective FREEZE cluster cohort study.

Author

Pongratz, Janis, Kuniss, Malte, Wu, Liqun, Tebbenjohanns, Jürgen, Nölker, Georg, Dorwarth, Uwe, Kuck, Karl‐Heinz, Jochen, Senges, Hoffmann, Ellen, and Straube, Florian

Subjects
*SURGICAL therapeutics, *CARDIAC surgery, *RELATIVE medical risk, *ATRIAL arrhythmias, *CONFIDENCE intervals, *TRANSESOPHAGEAL echocardiography, *MAJOR adverse cardiovascular events, *ATRIAL fibrillation, *CRYOSURGERY, *CATHETER ablation, *SURGICAL complications, *MANN Whitney U Test, *PATIENT readmissions, *DISEASE incidence, *RISK assessment, *CARDIAC tamponade, *COMPARATIVE studies, *FLUOROSCOPY, *SEX distribution, *DISEASE relapse, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *CHI-squared test, *PULMONARY veins, *ODDS ratio, *STATISTICAL models, *DATA analysis software, *LOGISTIC regression analysis, *SECONDARY analysis, *LEFT heart atrium, *LONGITUDINAL method, *DISEASE risk factors
Abstract

Introduction: Cryoballoon ablation (CBA) aiming at pulmonary vein isolation (PVI) became a standardized atrial fibrillation (AF) ablation procedure. Life‐threatening complications like cardiac tamponade exist. Intracardiac echocardiography (ICE) usage is associated with superior safety in radiofrequency ablation. It is unclear if ICE has an impact on safety of CBA. Methods: The FREEZE Cohort (NCT01360008) subanalysis included patients undergoing "PVI only" CBA. Patients with intraprocedural transesophageal echocardiography were excluded. Group A comprises conventional, group B ICE‐guided CBA. Periprocedural results were compared. Results: From 2011 to 2016, a total of 4189 patients were enrolled, and 1906 (45.5%) were included in this subanalysis, split up in two groups (A: 1066 [55.9%], B: 840 [44.1%]). Group A was younger (60.6 ± 10.8 vs. 62.4 ± 10.5 years, p <.001), with smaller left atria (41 vs. 43 mm, p <.001), and less persistent AF (23.1 vs. 38.1%, p <.001). Procedure, left atrial, and fluoroscopy times were shorter in group A as compared to group B. Dose area product was significantly higher in group A (2911 vs. 2072 cGyxcm2, p <.001). In‐hospital major adverse cerebrovascular and cardiac event rates including two deaths in group A were not different between groups (0.5% vs. 0.1%, p =.18). The rate of total procedural (10.4% vs. 5.1%, p <.001) and major complications (3.2% vs. 1.3%, p <.001) was significantly higher in group A. Cardiac tamponade occurred significantly more frequently in group A (8 [0.8%] vs. 1 [0.1%], p =.046). Independent predictors for major complications were female sex (odds ratio [OR] 2.03, p =.03) and non‐ICE usage (OR 2.38, p =.02). No differences were observed for persistent phrenic nerve palsy, nor for groin complications. Conclusion: CBA was significantly safer and required less radiation if ICE was used, although the procedures were more complex. The risk of groin complications was not increased with ICE usage. Non‐ICE usage was the only modifiable independent predictor of major complications. [ABSTRACT FROM AUTHOR]

Published
2023
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32. A rare case of right heart failure with the necessity for veno‐arterial extracorporeal membrane oxygenation following pulmonary vein stenosis after radiofrequency ablation for atrial fibrillation

Author

Kopp, Sabrina, primary, Tilch, Marie‐Kristin, additional, Sagoschen, Ingo, additional, Kaes, Joachim, additional, Kuniss, Malte, additional, Neumann, Thomas, additional, Yang, Yang, additional, Schnitzler, Katharina, additional, Schmidt, Kai‐Helge, additional, Rostock, Thomas, additional, Münzel, Thomas, additional, Konstantinides, Stavros, additional, Wild, Johannes, additional, and Hobohm, Lukas, additional

Published
2023
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33. Impact of cryoballoon application abortion due to phrenic nerve injury on reconnection rates: a YETI subgroup analysis

Author

Heeger, Christian-H, primary, Popescu, Sorin Ștefan, additional, Sohns, Christian, additional, Pott, Alexander, additional, Metzner, Andreas, additional, Inaba, Osamu, additional, Straube, Florian, additional, Kuniss, Malte, additional, Aryana, Arash, additional, Miyazaki, Shinsuke, additional, Cay, Serkan, additional, Ehrlich, Joachim R, additional, El-Battrawy, Ibrahim, additional, Martinek, Martin, additional, Saguner, Ardan M, additional, Tscholl, Verena, additional, Yalin, Kivanc, additional, Lyan, Evgeny, additional, Su, Wilber, additional, Papiashvili, Giorgi, additional, Botros, Maichel Sobhy Naguib, additional, Gasperetti, Alessio, additional, Proietti, Riccardo, additional, Wissner, Erik, additional, Scherr, Daniel, additional, Kamioka, Masashi, additional, Makimoto, Hisaki, additional, Urushida, Tsuyoshi, additional, Aksu, Tolga, additional, Chun, Julian K R, additional, Aytemir, Kudret, additional, Jędrzejczyk-Patej, Ewa, additional, Kuck, Karl-Heinz, additional, Dahme, Tillman, additional, Steven, Daniel, additional, Sommer, Philipp, additional, and Tilz, Roland Richard, additional

Published
2022
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34. Guideline Directed Medical Therapy at Discharge and Further Uptitration Leading to Reduction in Indication for Prophylactic ICD Implantation during Protected Waiting Period

Author

Waezsada, Elias, primary, Hutter, Julie, additional, Kahle, Patrick, additional, Yogarajah, Joerg, additional, Sperzel, Johannes, additional, Kuniss, Malte, additional, Neumann, Thomas, additional, Esser, Horst, additional, Hamm, Christian, additional, and Hain, Andreas, additional

Published
2022
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39. AV-Knoten-Reentrytachykardie: Diagnostik und Therapie

Author

von Bary, Christian, Eckardt, Lars, Steven, Daniel, Neuberger, Hans-Ruprecht, Tilz, Roland Richard, Bonnemeier, Hendrik, Thomas, Dierck, Deneke, Thomas, Estner, Heidi L., Kuniss, Malte, Luik, Armin, Sommer, Philipp, Voss, Frederik, Meyer, Christian, Shin, D.I., and Kriatselis, Charalampos

Published
2015
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41. Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry (Clinical Research in Cardiology, (2022), 111, 5, (560-573), 10.1007/s00392-022-01996-2)

Author

Lip, Gregory Y. H., Kotalczyk, Agnieszka, Teutsch, Christine, Diener, Hans-Christoph, Dubner, Sergio J., Halperin, Jonathan L., Ma, Chang-Sheng, Rothman, Kenneth J., Marler, Sabrina, Gurusamy, Venkatesh Kumar, Huisman, Menno V., Abban, Dzifa Wosornu, Aziz, Emad, Kalan, Marica Bracic, Abdul, Nasser, Backes, Luciano Marcelo, Bradman, Drew, Abud, Atilio Marcelo, Badings, E., Brautigam, Donald, Adams, Fran, Bagni, Ermentina, Breton, Nicolas, Addala, Srinivas, Baker, Seth H., Brouwers, P. J. A. M., Adragão, Pedro, Bala, Richard, Browne, Kevin, Ageno, Walter, Baldi, Antonio, Cortada, Jordi Bruguera, Aggarwal, Rajesh, Bando, Shigenobu, Bruni, A., Agosti, Sergio, Banerjee, Subhash, Brunschwig, Claude, Agostoni, Piergiuseppe, Bank, Alan, Buathier, Hervé, Aguilar, Francisco, Esquivias, Gonzalo Barón, Buhl, Aurélie, Linares, Julio Aguilar, Barr, Craig, Bullinga, John, Aguinaga, Luis, Bartlett, Maria, Cabrera, Jose Walter, Ahmed, Jameel, Basic Kes, Vanja, Caccavo, Alberto, Aiello, Allessandro, Baula, Giovanni, Cai, Shanglang, Ainsworth, Paul, Behrens, Steffen, Caine, Sarah, Aiub, Jorge Roberto, Bell, Alan, Calò, Leonardo, Al-Dallow, Raed, Benedetti, Raffaella, Calvi, Valeria, Alderson, Lisa, Mazuecos, Juan Benezet, Sánchez, Mauricio Camarillo, Velasco, Jorge Antonio Aldrete, Benhalima, Bouziane, Candeias, Rui, Alexopoulos, Dimitrios, Bergler-Klein, Jutta, Capuano, Vincenzo, Manterola, Fernando Alfonso, Berneau, Jean-Baptiste, Capucci, Alessandro, Aliyar, Pareed, Bernstein, Richard A., Caputo, Ronald, Alonso, David, Berrospi, Percy, Rizo, Tatiana C. rdenas, da Costa, Fernando Augusto Alves, Berti, Sergio, Cardona, Francisco, Amado, José, Berz, Andrea, da Costa Darrieux, Francisco Carlos, Amara, Walid, Best, Elizabeth, Vera, Yan Carlos Duarte, Amelot, Mathieu, Bettencourt, Paulo, Carolei, Antonio, Amjadi, Nima, Betzu, Robert, Carreño, Susana, Ammirati, Fabrizio, Bhagwat, Ravi, Carvalho, Paula, Andrade, Marianna, Bhatta, Luna, Cary, Susanna, Andrawis, Nabil, Biscione, Francesco, Casu, Gavino, Annoni, Giorgio, Bisignani, Giovanni, Cavallini, Claudio, Ansalone, Gerardo, Black, Toby, Cayla, Guillaume, Ariani, M. Kevin, Bloch, Michael J., Celentano, Aldo, Arias, Juan Carlos, Bloom, Stephen, Cha, Tae-Joon, Armero, S. bastien, Blumberg, Edwin, Cha, Kwang Soo, Arora, Chander, Bo, Mario, Chae, Jei Keon, Aslam, Muhammad Shakil, Bøhmer, Ellen, Chalamidas, Kathrine, Asselman, M., Bollmann, Andreas, Challappa, Krishnan, Audouin, Philippe, Bongiorni, Maria Grazia, Chand, Sunil Prakash, Augenbraun, Charles, Boriani, Giuseppe, Chandrashekar, Harinath, Aydin, S., Boswijk, D. J., Chartier, Ludovic, Bott, Jochen, Chatterjee, Kausik, Ayryanova, Ivaneta, Bottacchi, Edo, Ayala, Carlos Antero Chavez, Cheema, Aamir, Davis, Gershan, Evonich, Rudolph, Cheema, Amjad, Davy, Jean-Marc, Evseeva, Oksana, Chen, Lin, Dayer, Mark, Ezhov, Andrey, Chen, Shih-Ann, de Biasio, Marzia, Fahmy, Raed, Chen, Jyh Hong, de Bonis, Silvana, Fang, Quan, Chiang, Fu-Tien, de Caterina, Raffaele, Farsad, Ramin, Chiarella, Francesco, de Franceschi, Teresiano, Fauchier, Laurent, Chih-Chan, Lin, de Groot, J. 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Abstract

In this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected.

Published
2022

42. Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry

Author

Heeger, Christian-H, Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R., El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M., Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K. R., Aytemir, Kudret, Jedrzejczyk-Patej, Ewa, Kuck, Karl-Heinz, Dahme, Tillman, Steven, Daniel, Sommer, Philipp, Tilz, Roland Richard, Heeger, Christian-H, Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R., El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M., Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K. R., Aytemir, Kudret, Jedrzejczyk-Patej, Ewa, Kuck, Karl-Heinz, Dahme, Tillman, Steven, Daniel, Sommer, Philipp, and Tilz, Roland Richard

Abstract

Background: Cryoballoon-based pulmonary vein isolation (PVI) has emerged as an effective treatment for atrial fibrillation. The most frequent complication during cryoballoon-based PVI is phrenic nerve injury (PNI). However, data on PNI are scarce. Methods: The YETI registry is a retrospective, multicenter, and multinational registry evaluating the incidence, characteristics, prognostic factors for PNI recovery and follow-up data of patients with PNI during cryoballoon-based PVI. Experienced electrophysiological centers were invited to participate. All patients with PNI during CB2 or third (CB3) and fourth-generation cryoballoon (CB4)-based PVI were eligible. Results: A total of 17 356 patients underwent cryoballoon-based PVI in 33 centers from 10 countries. A total of 731 (4.2%) patients experienced PNI. The mean time to PNI was 127.7 +/- 50.4 seconds, and the mean temperature at the time of PNI was -49 +/- 8 degrees C. At the end of the procedure, PNI recovered in 394/731 patients (53.9%). Recovery of PNI at 12 months of follow-up was found in 97.0% of patients (682/703, with 28 patients lost to follow-up). A total of 16/703 (2.3%) reported symptomatic PNI. Only 0.06% of the overall population showed symptomatic and permanent PNI. Prognostic factors improving PNI recovery are immediate stop at PNI by double-stop technique and utilization of a bonus-freeze protocol. Age, cryoballoon temperature at PNI, and compound motor action potential amplitude loss >30% were identified as factors decreasing PNI recovery. Based on these parameters, a score was calculated. The YETI score has a numerical value that will directly represent the probability of a specific patient of recovering from PNI within 12 months. Conclusions: The incidence of PNI during cryoballoon-based PVI was 4.2%. Overall 97% of PNI recovered within 12 months. Symptomatic and permanent PNI is exceedingly rare in patients after cryoballoon-based PVI. The YETI score estimates the prognosis after iatrogenic cry

Published
2022

43. Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry

Author

Heeger, Christian-H; https://orcid.org/0000-0002-9014-8097, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Pott, Alexander, Metzner, Andreas, Inaba, Osamu; https://orcid.org/0000-0003-2179-3786, Straube, Florian; https://orcid.org/0000-0002-4491-5224, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Aryana, Arash; https://orcid.org/0000-0003-0932-8400, Miyazaki, Shinsuke; https://orcid.org/0000-0002-0230-0934, Cay, Serkan; https://orcid.org/0000-0002-5476-1214, Ehrlich, Joachim R; https://orcid.org/0000-0002-5803-9843, El-Battrawy, Ibrahim; https://orcid.org/0000-0002-0139-1045, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Tscholl, Verena; https://orcid.org/0000-0003-2748-2540, Yalin, Kivanc; https://orcid.org/0000-0001-5602-0711, Lyan, Evgeny; https://orcid.org/0000-0001-9696-9227, Su, Wilber; https://orcid.org/0000-0002-0639-6822, Papiashvili, Giorgi; https://orcid.org/0000-0002-6183-6683, Botros, Maichel Sobhy Naguib; https://orcid.org/0000-0003-1521-1495, Gasperetti, Alessio; https://orcid.org/0000-0003-3432-070X, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi; https://orcid.org/0000-0001-6588-0764, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga; https://orcid.org/0000-0001-8061-9660, Chun, Julian K R; https://orcid.org/0000-0002-2355-6015, Aytemir, Kudret; https://orcid.org/0000-0001-9279-8424, et al, Heeger, Christian-H; https://orcid.org/0000-0002-9014-8097, Sohns, Christian; https://orcid.org/0000-0003-0490-5862, Pott, Alexander, Metzner, Andreas, Inaba, Osamu; https://orcid.org/0000-0003-2179-3786, Straube, Florian; https://orcid.org/0000-0002-4491-5224, Kuniss, Malte; https://orcid.org/0000-0002-1593-9657, Aryana, Arash; https://orcid.org/0000-0003-0932-8400, Miyazaki, Shinsuke; https://orcid.org/0000-0002-0230-0934, Cay, Serkan; https://orcid.org/0000-0002-5476-1214, Ehrlich, Joachim R; https://orcid.org/0000-0002-5803-9843, El-Battrawy, Ibrahim; https://orcid.org/0000-0002-0139-1045, Martinek, Martin; https://orcid.org/0000-0002-8895-8488, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Tscholl, Verena; https://orcid.org/0000-0003-2748-2540, Yalin, Kivanc; https://orcid.org/0000-0001-5602-0711, Lyan, Evgeny; https://orcid.org/0000-0001-9696-9227, Su, Wilber; https://orcid.org/0000-0002-0639-6822, Papiashvili, Giorgi; https://orcid.org/0000-0002-6183-6683, Botros, Maichel Sobhy Naguib; https://orcid.org/0000-0003-1521-1495, Gasperetti, Alessio; https://orcid.org/0000-0003-3432-070X, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi; https://orcid.org/0000-0001-6588-0764, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga; https://orcid.org/0000-0001-8061-9660, Chun, Julian K R; https://orcid.org/0000-0002-2355-6015, Aytemir, Kudret; https://orcid.org/0000-0001-9279-8424, and et al

Abstract

BACKGROUND Cryoballoon-based pulmonary vein isolation (PVI) has emerged as an effective treatment for atrial fibrillation. The most frequent complication during cryoballoon-based PVI is phrenic nerve injury (PNI). However, data on PNI are scarce. METHODS The YETI registry is a retrospective, multicenter, and multinational registry evaluating the incidence, characteristics, prognostic factors for PNI recovery and follow-up data of patients with PNI during cryoballoon-based PVI. Experienced electrophysiological centers were invited to participate. All patients with PNI during CB2 or third (CB3) and fourth-generation cryoballoon (CB4)-based PVI were eligible. RESULTS A total of 17 356 patients underwent cryoballoon-based PVI in 33 centers from 10 countries. A total of 731 (4.2%) patients experienced PNI. The mean time to PNI was 127.7±50.4 seconds, and the mean temperature at the time of PNI was -49±8°C. At the end of the procedure, PNI recovered in 394/731 patients (53.9%). Recovery of PNI at 12 months of follow-up was found in 97.0% of patients (682/703, with 28 patients lost to follow-up). A total of 16/703 (2.3%) reported symptomatic PNI. Only 0.06% of the overall population showed symptomatic and permanent PNI. Prognostic factors improving PNI recovery are immediate stop at PNI by double-stop technique and utilization of a bonus-freeze protocol. Age, cryoballoon temperature at PNI, and compound motor action potential amplitude loss >30% were identified as factors decreasing PNI recovery. Based on these parameters, a score was calculated. The YETI score has a numerical value that will directly represent the probability of a specific patient of recovering from PNI within 12 months. CONCLUSIONS The incidence of PNI during cryoballoon-based PVI was 4.2%. Overall 97% of PNI recovered within 12 months. Symptomatic and permanent PNI is exceedingly rare in patients after cryoballoon-based PVI. The YETI score estimates the prognosis after iatrogenic cryoballoon-derived PNI

Published
2022

47. PO-651-01 THE YETI REGISTRY: RESULTS OF A WORLD-WIDE ANALYSIS OF PHRENIC NERVE INJURY DURING CRYOBALOON BASED PULMONARY VEIN ISOLATION

Author

Heeger, Christian H., primary, Sohns, Christian, additional, Pott, Alexander, additional, Metzner, Andreas, additional, Inaba, Osamu, additional, Straube, Florian, additional, Kuniss, Malte, additional, Aryana, Arash, additional, Miyazaki, Shinsuke, additional, CAY, SERKAN, additional, Ehrlich, Joachim R., additional, Martinek, Martin, additional, Saguner, Ardan, additional, Tscholl, Verena, additional, Yalin, Kivanc, additional, Lyan, Evgeny, additional, Su, Wilber W., additional, Papiashvili, Giorgi, additional, Sobhy naguib Botros, MAICHEL, additional, Gasperetti, Alessio, additional, Proietti, Riccardo, additional, Wissner, Erik, additional, Scherr, Daniel, additional, Kamioka, Masashi, additional, Makimoto, Hisaki, additional, Aksu, Tolga, additional, Kyoung-Ryul Chun, Julian, additional, AYTEMIR, KUDRET, additional, Kuck, Karl-Heinz, additional, Dahme, Tillman, additional, Steven, Daniel, additional, Sommer, Philipp, additional, and Tilz, Roland R., additional

Published
2022
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50. Cryoballoon Ablation as Initial Treatment for Atrial Fibrillation

Author

Andrade, Jason G, Wazni, Oussama M, Kuniss, Malte, Hawkins, Nathaniel M, Deyell, Marc W, Chierchia, Gian-Battista, Nissen, Steven, Verma, Atul, Wells, George A, Turgeon, Ricky D, Clinical sciences, and Heartrhythmmanagement

Subjects
Cryotherapy, cryoballoon, Atrial Fibrillation, Catheter Ablation, Ablation, Cardiology and Cardiovascular Medicine, Antiarrhythmic drugs
Abstract

Atrial fibrillation (AF), the most common sustained arrhythmia observed in clinical practice, is a chronic and progressive disorder characterized by exacerbations and remissions. Guidelines recommend antiarrhythmic drugs as the initial therapy for the maintenance of sinus rhythm; however, antiarrhythmic drugs have modest efficacy to maintain sinus rhythm and can be associated with significant adverse effects. An initial treatment strategy of cryoballoon catheter ablation in patients with treatment-naïve AF has been shown to significantly improve arrhythmia outcomes (freedom from any, or symptomatic atrial tachyarrhythmia), produce clinically meaningful improvements in patient-reported outcomes (symptoms and quality of life), and significantly reduce subsequent health care resource use (hospitalization), and it does not increase the risk of serious or any adverse events compared with initial antiarrhythmic drug therapy. These findings are relevant to inform patients, providers, and health care systems regarding the initial choice of rhythm-control therapy in patients with treatment-naïve AF.

Published
2021

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