Author: "Kung, Pei-Pei" / Publication Year Range: Last 50 years - Searchworks@Jio Institute Digital Library Search Results

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166 results on '"Kung, Pei-Pei"'

1. Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

Author: Sharma, Shikhar, Chung, Chi-Yeh, Uryu, Sean, Petrovic, Jelena, Cao, Joan, Rickard, Amanda, Nady, Nataliya, Greasley, Samantha, Johnson, Eric, Brodsky, Oleg, Khan, Showkhin, Wang, Hui, Wang, Zhenxiong, Zhang, Yong, Tsaparikos, Konstantinos, Chen, Lei, Mazurek, Anthony, Lapek, John, Kung, Pei-Pei, Sutton, Scott, Richardson, Paul F., Greenwald, Eric C., Yamazaki, Shinji, Jones, Rhys, Maegley, Karen A., Bingham, Patrick, Lam, Hieu, Stupple, Alexandra E., Kamal, Aileen, Chueh, Anderly, Cuzzupe, Anthony, Morrow, Benjamin J., Ren, Bin, Carrasco-Pozo, Catalina, Tan, Chin Wee, Bhuva, Dharmesh D., Allan, Elizabeth, Surgenor, Elliot, Vaillant, François, Pehlivanoglu, Havva, Falk, Hendrik, Whittle, James R., Newman, Janet, Cursons, Joseph, Doherty, Judy P., White, Karen L., MacPherson, Laura, Devlin, Mark, Dennis, Matthew L., Hattarki, Meghan K., De Silva, Melanie, Camerino, Michelle A., Butler, Miriam S., Dolezal, Olan, Pilling, Patricia, Foitzik, Richard, Stupple, Paul A., Lagiakos, H. Rachel, Walker, Scott R., Hediyeh-Zadeh, Soroor, Nuttall, Stewart, Spall, Sukhdeep K., Charman, Susan A., Connor, Theresa, Peat, Thomas S., Avery, Vicky M., Bozikis, Ylva E., Yang, Yuqing, Zhang, Ming, Monahan, Brendon J., Voss, Anne K., Thomas, Tim, Street, Ian P., Dawson, Sarah-Jane, Dawson, Mark A., Lindeman, Geoffrey J., Davis, Melissa J., Visvader, Jane E., and Paul, Thomas A.
Published: 2023
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2. To Market, to Market—2020: Macromolecular Therapeutics

Author: Agard, Nicholas J., primary, Dragovich, Peter S., additional, Kelly, Ryan L., additional, Lim, Shion A., additional, Beal, Allison M., additional, Moench, Ian, additional, Gram, Anna M., additional, Kung, Pei-Pei, additional, and Lipovšek, Daša, additional
Published: 2021
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3. Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)

Author: Wang, Jocelyn, primary, Nakafuku, Kohki M., additional, Ziff, Jeannie, additional, Gelin, Christine F., additional, Gholami, Hadi, additional, Thompson, Aaron A., additional, Karpowich, Nathan K., additional, Limon, Luis, additional, Coate, Heather R., additional, Damm-Ganamet, Kelly L., additional, Shih, Amy Y., additional, Grant, Joanna C., additional, Côte, Marjorie, additional, Mak, Puiying A., additional, Pascual, Heather A., additional, Rives, Marie-Laure, additional, Edwards, James P., additional, Venable, Jennifer D., additional, Venkatesan, Hariharan, additional, Shi, Zhicai, additional, Allen, Samantha J., additional, Sharma, Sujata, additional, Kung, Pei-Pei, additional, and Shireman, Brock T., additional
Published: 2023
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4. Identification of small-molecule protein–protein interaction inhibitors for NKG2D

Author: Thompson, Aaron A., primary, Harbut, Michael B., additional, Kung, Pei-Pei, additional, Karpowich, Nathan K., additional, Branson, Jeffrey D., additional, Grant, Joanna C., additional, Hagan, Deborah, additional, Pascual, Heather A., additional, Bai, Guoyun, additional, Zavareh, Reza Beheshti, additional, Coate, Heather R., additional, Collins, Bernard C., additional, Côte, Marjorie, additional, Gelin, Christine F., additional, Damm-Ganamet, Kelly L., additional, Gholami, Hadi, additional, Huff, Adam R., additional, Limon, Luis, additional, Lumb, Kevin J., additional, Mak, Puiying A., additional, Nakafuku, Kohki M., additional, Price, Edmund V., additional, Shih, Amy Y., additional, Tootoonchi, Mandana, additional, Vellore, Nadeem A., additional, Wang, Jocelyn, additional, Wei, Na, additional, Ziff, Jeannie, additional, Berger, Scott B., additional, Edwards, James P., additional, Gardet, Agnès, additional, Sun, Siquan, additional, Towne, Jennifer E., additional, Venable, Jennifer D., additional, Shi, Zhicai, additional, Venkatesan, Hariharan, additional, Rives, Marie-Laure, additional, Sharma, Sujata, additional, Shireman, Brock T., additional, and Allen, Samantha J., additional
Published: 2023
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5. Supplementary Table 3 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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6. Supplementary Figure 3 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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7. Supplementary Figure 1 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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8. Supplementary Figure 2 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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9. Supplementary Figure 4 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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10. Supplementary Materials and Methods from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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11. Supplementary Table 2 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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12. Supplementary Table 1 from Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, primary, Zhu, Zhou, primary, Zager, Michael, primary, Blasina, Alessandra, primary, Rymer, Isha, primary, Hallin, Jill, primary, Xu, Meirong, primary, Carroll, Christopher, primary, Chionis, John, primary, Wells, Peter, primary, Kozminski, Kirk, primary, Fan, Jeffery, primary, Guicherit, Oivin, primary, Huang, Buwen, primary, Cui, Mei, primary, Liu, Chaoting, primary, Huang, Zhongdong, primary, Sistla, Anand, primary, Yang, Jennifer, primary, and Murray, Brion W., primary
Published: 2023
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13. Supplementary Table 1 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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14. Supplementary Figure 4 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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15. Supplementary Table 2 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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16. Supplementary Figure 2 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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17. Supplementary Figure 3 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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18. Data from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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19. Supplementary Legends for Figures 1-4, and Tables 1-2 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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20. Supplementary Table 3 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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21. Supplementary Figure 1 from Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90

Author: Mehta, Pramod P., primary, Whalen, Pamela, primary, Baxi, Sangita M., primary, Kung, Pei-Pei, primary, Yamazaki, Shinji, primary, and Yin, Min-Jean, primary
Published: 2023
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22. Data from An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Author: Zou, Helen Y., primary, Li, Qiuhua, primary, Lee, Joseph H., primary, Arango, Maria E., primary, McDonnell, Scott R., primary, Yamazaki, Shinji, primary, Koudriakova, Tatiana B., primary, Alton, Gordon, primary, Cui, Jingrong J., primary, Kung, Pei-Pei, primary, Nambu, Mitchell D., primary, Los, Gerrit, primary, Bender, Steven L., primary, Mroczkowski, Barbara, primary, and Christensen, James G., primary
Published: 2023
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23. Supplementary Tables 1-2, Figures 1-3 from An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Author: Zou, Helen Y., primary, Li, Qiuhua, primary, Lee, Joseph H., primary, Arango, Maria E., primary, McDonnell, Scott R., primary, Yamazaki, Shinji, primary, Koudriakova, Tatiana B., primary, Alton, Gordon, primary, Cui, Jingrong J., primary, Kung, Pei-Pei, primary, Nambu, Mitchell D., primary, Los, Gerrit, primary, Bender, Steven L., primary, Mroczkowski, Barbara, primary, and Christensen, James G., primary
Published: 2023
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24. Harnessing Ionic Selectivity in Acetyltransferase Chemoproteomic Probes

Author: Yihang Jing, Laurence Florens, Michael P. Washburn, Jose L Montano, Paul F. Richardson, Krzysztof Krajewski, Jordan L. Meier, Michaella J. Levy, Kung Pei-Pei, and Jeffrey E. Lopez
Subjects: Proteomics, Coenzyme A, Quantitative proteomics, Computational biology, Biochemistry, Article, Cofactor, Substrate Specificity, Sepharose, chemistry.chemical_compound, Acetyltransferases, Tandem Mass Spectrometry, Amino Acid Sequence, Chromatography, High Pressure Liquid, biology, Chemistry, Reproducibility of Results, General Medicine, Small molecule, Molecular Probes, Acetyltransferase, biology.protein, Molecular Medicine, Electrophoresis, Polyacrylamide Gel, Selectivity
Abstract: Chemical proteomics provides a powerful strategy for the high-throughput assignment of enzyme function or inhibitor selectivity. However, identifying optimized probes for an enzyme family member of interest and differentiating signal from background remain persistent challenges in the field. To address this obstacle, here we report a physiochemical discernment strategy for optimizing chemical proteomics based on the Coenzyme A (CoA) cofactor. First, we synthesize a pair of CoA-based Sepharose pulldown resins differentiated by a single negatively charged residue, and find this change alters their capture properties in gel-based profiling experiments. Next, we integrate these probes with quantitative proteomics and benchmark analysis of ‘probe selectivity’ versus traditional ‘competitive chemical proteomics’. This reveals the former is well-suited for the identification of optimized pulldown probes for specific enzyme family members, while the latter may have advantages in discovery applications. Finally, we apply our anionic CoA pulldown probe to evaluate the selectivity of a recently reported small molecule N-terminal acetyltransferase inhibitor. These studies further validate the use of physical discriminant strategies in chemoproteomic hit identification and demonstrate how CoA-based chemoproteomic probes can be used to evaluate the selectivity of small molecule protein acetyltransferase inhibitors, an emerging class of pre-clinical therapeutic agents.
Published: 2020
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25. Biotransformation-mediated synthesis of (1 S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form

Author: Martinez, Carlos A., Keller, Eric, Meijer, Renzo, Metselaar, Gerard, Kruithof, Gerlof, Moore, Curtis, and Kung, Pei-Pei
Published: 2010
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26. Abstract 1130: First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER+ breast cancer with KAT6A dysregulation

Author: Sharma, Shikhar, primary, Chung, Jay, additional, Uryu, Sean, additional, Rickard, Amanda, additional, Nady, Natalie, additional, Khan, Showkhin, additional, Wang, Zhenxiong, additional, Zhang, Yong, additional, Zhang, Haikuo, additional, Kung, Pei-Pei, additional, Greenwald, Eric, additional, Maegley, Karen, additional, Bingham, Patrick, additional, Lam, Hieu, additional, Bozikis, Ylva E., additional, Falk, Hendrik, additional, Allan, Elizabeth, additional, Avery, Vicky M., additional, Butler, Miriam S., additional, Camerino, Michelle A., additional, Carrasco-Pozo, Catalina, additional, Charman, Susan A., additional, Davis, Melissa J., additional, Dawson, Mark A., additional, Sarah-Jane, Dawson, additional, de Silva, Melanie, additional, Dennis, Matthew L., additional, Dolezal, Olan, additional, Lagiakos, Rachel, additional, Lindeman, Geoffrey J., additional, MacPherson, Laura, additional, Nuttall, Stewart, additional, Peat, Thomas S., additional, Ren, Bin, additional, Stupple, Alexandra E., additional, Surgenor, Elliot, additional, Tan, Chin Wee, additional, Thomas, Tim, additional, Visvader, Jane E., additional, Voss, Anne K., additional, Vaillant, Francois, additional, White, Karen L., additional, Whittle, James, additional, Yang, Yuqing, additional, Hediyeh-Zadeh, Soroor, additional, Stupple, Paul A., additional, Street, Ian P., additional, Monahan, Brendon J., additional, and Paul, Thomas, additional
Published: 2021
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27. Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug

Author: Kung, Pei-Pei, primary, Fan, Connie, additional, Gukasyan, Hovhannes J., additional, Huang, Buwen, additional, Kephart, Susan, additional, Kraus, Manfred, additional, Lee, Joseph H., additional, Sutton, Scott C., additional, Yamazaki, Shinji, additional, and Zehnder, Luke, additional
Published: 2021
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28. Harnessing Ionic Selectivity in Acetyltransferase Chemoproteomic Probes

Author: Jing, Yihang, primary, Montano, Jose L., additional, Levy, Michaella, additional, Lopez, Jeffrey E., additional, Kung, Pei-Pei, additional, Richardson, Paul, additional, Krajewski, Krzysztof, additional, Florens, Laurence, additional, Washburn, Michael P., additional, and Meier, Jordan L., additional
Published: 2020
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29. Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

Author: Kung, Pei-Pei, primary, Bingham, Patrick, additional, Burke, Benjamin J., additional, Chen, Qiuxia, additional, Cheng, Xuemin, additional, Deng, Ya-Li, additional, Dou, Dengfeng, additional, Feng, Junli, additional, Gallego, Gary M., additional, Gehring, Michael R., additional, Grant, Stephan K., additional, Greasley, Samantha, additional, Harris, Anthony R., additional, Maegley, Karen A., additional, Meier, Jordan, additional, Meng, Xiaoyun, additional, Montano, Jose L., additional, Morgan, Barry A., additional, Naughton, Brigitte S., additional, Palde, Prakash B., additional, Paul, Thomas A., additional, Richardson, Paul, additional, Sakata, Sylvie, additional, Shaginian, Alex, additional, Sonnenburg, William K., additional, Subramanyam, Chakrapani, additional, Timofeevski, Sergei, additional, Wan, Jinqiao, additional, Yan, Wen, additional, and Stewart, Albert E., additional
Published: 2020
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30. Solution-phase synthesis of novel linear oxyamine combinatorial libraries with antibacterial activity

Author: Kung, Pei-Pei, Bharadwaj, Ramesh, Fraser, Allister S., Cook, Daniel R., Kawasaki, Andrew M., and Cook, P. Dan
Subjects: Antibacterial agents -- Research, Organic compounds -- Synthesis, Biological sciences, Chemistry
Abstract: A new class of oxyamine-containing antibacterial compounds was discovered with the use of solution phase combinatorial library synthesis. These combinatorial libraries were based on novel structures, instead of known pharmacophore structures usually employed in combinatorial chemistry. With an oxyamino-containing linear scaffold, control of product distribution was achieved through reaction with both acylating and alkylating agents. Reductive cleavage of the oxyamine moiety allowed library structure-activity relationship analysis.
Published: 1998

31. 6-O-(pentafluorophenyl)-2'-deoxyguanosine: a versatile synthon for nucleoside and oligonucleotide synthesis

Author: Gao, Hetian, Fathi, Reza, Gaffney, Barbara L., Goswami, Bhaswati, Kung, Pei-Pei, Rhee, Youngsook, Jin, Renzhe, and Jones, Roger A.
Subjects: Guanosine -- Research, Nucleotides -- Research, Guanine -- Research, Biological sciences, Chemistry
Abstract: The syntheses of 6-O-methyl-2'-deoguanosine, 2,6-diamino-9-(2-deoxy-beta-D- erythro-pentofuranosyl)purine and their derivatives from 6-O- (pentafluorophenyl)-2'-deoguanosine derivative (1) were reported. The introduction of 1 in oligonucleotides for postsynthetic modification led to the formation of molecules containing 2,6-diaminopurine residues and their 6-aminoalkyl derivative or guanine-DMAP adducts.
Published: 1992

32. Harnessing Ionic Selectivity in Acetyltransferase Chemoproteomic Probes.

Author: Jing, Yihang, Montano, Jose L., Levy, Michaella, Lopez, Jeffrey E., Kung, Pei-Pei, Richardson, Paul, Krajewski, Krzysztof, Florens, Laurence, Washburn, Michael P., and Meier, Jordan L.
Published: 2021
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33. Retraction notice to “A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells”

Author: Mehta, Pramod P., primary, Kung, Pei-Pei, additional, Yamazaki, Shinji, additional, Walls, Marlena, additional, Shen, Andrea, additional, Nguyen, Leslie, additional, Gehring, Michael R., additional, Los, Gerrit, additional, Smeal, Tod, additional, and Yin, Min-Jean, additional
Published: 2018
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34. Use of 15N NMR to probe Hoogsteen hydrogen bonding at guanine and adenine N7 atoms of a DNA triplex

Author: Gaffney, Barbara L., Kung, Pei-Pei, Wang, Chuan, and Jones, Roger A.
Subjects: Oligodeoxynucleotides -- Research, Hydrogen bonding -- Research, DNA -- Research, Chemistry
Abstract: The nitrogen-15-labeled deoxyguanosine and deoxyadenosine probe the Hoogsteen hydrogen bonding to the purine N7 atoms in C+.GC and T.AT DNA triplexes. A 21 base pair duplex and a third 15 base strand make up the triplex. The chemical shift changes depend on the hydrogen bond stability formed between the donor and acceptor groups.
Published: 1995

35. Solid phase synthesis of tetrahydropyrazine-2-ones by intramolecular Mitsunobu reactions

Author: Kung, Pei-Pei and Swayze, Eric
Published: 1999
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36. SAH derived potent and selective EZH2 inhibitors

Author: Kung, Pei-Pei, Huang, Buwen, Zehnder, Luke, Tatlock, John, Bingham, Patrick, Krivacic, Cody, Gajiwala, Ketan, Diehl, Wade, Yu, Xiu, and Maegley, Karen A.
Published: 2015
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37. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

Author: Kung, Pei-Pei, primary, Bingham, Patrick, additional, Brooun, Alexei, additional, Collins, Michael, additional, Deng, Ya-Li, additional, Dinh, Dac, additional, Fan, Connie, additional, Gajiwala, Ketan S., additional, Grantner, Rita, additional, Gukasyan, Hovhannes J., additional, Hu, Wenyue, additional, Huang, Buwen, additional, Kania, Robert, additional, Kephart, Susan E., additional, Krivacic, Cody, additional, Kumpf, Robert A., additional, Khamphavong, Penney, additional, Kraus, Manfred, additional, Liu, Wei, additional, Maegley, Karen A., additional, Nguyen, Lisa, additional, Ren, Shijian, additional, Richter, Dan, additional, Rollins, Robert A., additional, Sach, Neal, additional, Sharma, Shikhar, additional, Sherrill, John, additional, Spangler, Jillian, additional, Stewart, Albert E., additional, Sutton, Scott, additional, Uryu, Sean, additional, Verhelle, Dominique, additional, Wang, Hui, additional, Wang, Shuiwang, additional, Wythes, Martin, additional, Xin, Shuibo, additional, Yamazaki, Shinji, additional, Zhu, Huichun, additional, Zhu, JinJiang, additional, Zehnder, Luke, additional, and Edwards, Martin, additional
Published: 2017
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38. Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

Author: Zehnder, Luke, Bennett, Michael, Meng, Jerry, Huang, Buwen, Ninkovic, Sacha, Wang, Fen, Braganza, John, Tatlock, John, Jewell, Tanya, Zhou, Joe Zhongxiang, Burke, Ben, Wang, Jeff, Maegley, Karen, Mehta, Pramod P., Yin, Min-Jean, Gajiwala, Ketan S., Hickey, Michael J., Yamazaki, Shinji, Smith, Evan, Kang, Ping, Sistla, Anand, Dovalsantos, Elena, Gehring, Michael R., Kania, Robert, Wythes, Martin, and Kung, Pei-Pei
Abstract: A novel class of heat shock protein 90 (Hsp90) inhibitors was discovered by high-throughput screening and was subsequently optimized using a combination of structure-based design, parallel synthesis, and the application of medicinal chemistry principles. Through this process, the biochemical and cell-based potency of the original HTS lead were substantially improved along with the corresponding metabolic stability properties. These efforts culminated with the identification of a development candidate (compound 42) which displayed desired PK/PD relationships, significant efficacy in a melanoma A2058 xenograft tumor model, and attractive DMPK profiles.
Published: 2024
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39. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

Author: Kung, Pei-Pei, Bingham, Patrick, Brooun, Alexei, Collins, Michael, Deng, Ya-Li, Dinh, Dac, Fan, Connie, Gajiwala, Ketan S., Grantner, Rita, Gukasyan, Hovhannes J., Hu, Wenyue, Huang, Buwen, Kania, Robert, Kephart, Susan E., Krivacic, Cody, Kumpf, Robert A., Khamphavong, Penney, Kraus, Manfred, Liu, Wei, Maegley, Karen A., Nguyen, Lisa, Ren, Shijian, Richter, Dan, Rollins, Robert A., Sach, Neal, Sharma, Shikhar, Sherrill, John, Spangler, Jillian, Stewart, Albert E., Sutton, Scott, Uryu, Sean, Verhelle, Dominique, Wang, Hui, Wang, Shuiwang, Wythes, Martin, Xin, Shuibo, Yamazaki, Shinji, Zhu, Huichun, Zhu, JinJiang, Zehnder, Luke, and Edwards, Martin
Abstract: A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors incorporated an sp3hybridized carbon atom at the 7-position of the lactam moiety present in lead compound 1as a replacement for a dimethylisoxazole group. This transformation enabled optimization of the physicochemical properties and potency compared to compound 1. Analysis of relationships between calculated log D(clogD) values and in vitro metabolic stability and permeability parameters identified a clogD range that afforded an increased probability of achieving favorable ADME data in a single molecule. Compound 23aexhibited the best overlap of potency and pharmaceutical properties as well as robust tumor growth inhibition in vivo and was therefore advanced as a development candidate (PF-06821497). A crystal structure of 23ain complex with the three-protein PRC2 complex enabled understanding of the key structural features required for optimal binding.
Published: 2024
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40. Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Author: Kung, Pei-Pei, primary, Rui, Eugene, additional, Bergqvist, Simon, additional, Bingham, Patrick, additional, Braganza, John, additional, Collins, Michael, additional, Cui, Mei, additional, Diehl, Wade, additional, Dinh, Dac, additional, Fan, Connie, additional, Fantin, Valeria R., additional, Gukasyan, Hovhannes J., additional, Hu, Wenyue, additional, Huang, Buwen, additional, Kephart, Susan, additional, Krivacic, Cody, additional, Kumpf, Robert A., additional, Li, Gary, additional, Maegley, Karen A., additional, McAlpine, Indrawan, additional, Nguyen, Lisa, additional, Ninkovic, Sacha, additional, Ornelas, Martha, additional, Ryskin, Michael, additional, Scales, Stephanie, additional, Sutton, Scott, additional, Tatlock, John, additional, Verhelle, Dominique, additional, Wang, Fen, additional, Wells, Peter, additional, Wythes, Martin, additional, Yamazaki, Shinji, additional, Yip, Brian, additional, Yu, Xiu, additional, Zehnder, Luke, additional, Zhang, Wei-Guo, additional, Rollins, Robert A., additional, and Edwards, Martin, additional
Published: 2016
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41. Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Author: Kung, Pei-Pei, primary, Rui, Eugene, additional, Bergqvist, Simon, additional, Bingham, Patrick, additional, Braganza, John, additional, Collins, Michael, additional, Cui, Mei, additional, Diehl, Wade, additional, Dinh, Dac, additional, Fan, Connie, additional, Fantin, Valeria R., additional, Gukasyan, Hovhannes J., additional, Hu, Wenyue, additional, Huang, Buwen, additional, Kephart, Susan, additional, Krivacic, Cody, additional, Kumpf, Robert A., additional, Li, Gary, additional, Maegley, Karen A., additional, McAlpine, Indrawan, additional, Nguyen, Lisa, additional, Ninkovic, Sacha, additional, Ornelas, Martha, additional, Ryskin, Michael, additional, Scales, Stephanie, additional, Sutton, Scott, additional, Tatlock, John, additional, Verhelle, Dominique, additional, Wang, Fen, additional, Wells, Peter, additional, Wythes, Martin, additional, Yamazaki, Shinji, additional, Yip, Brian, additional, Yu, Xiu, additional, Zehnder, Luke, additional, Zhang, Wei-Guo, additional, Rollins, Robert A., additional, and Edwards, Martin, additional
Published: 2016
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42. Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Author: Brooun, Alexei, primary, Gajiwala, Ketan S., additional, Deng, Ya-Li, additional, Liu, Wei, additional, Bolaños, Ben, additional, Bingham, Patrick, additional, He, You-Ai, additional, Diehl, Wade, additional, Grable, Nicole, additional, Kung, Pei-Pei, additional, Sutton, Scott, additional, Maegley, Karen A., additional, Yu, Xiu, additional, and Stewart, Al E., additional
Published: 2016
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43. Crizotinib (Xalkori): The First‐in‐Class ALK/ROS Inhibitor for Non‐small Cell Lung Cancer

Author: Kung, Pei‐Pei, primary, Jones, Ricky Anthony, additional, and Richardson, Paul, additional
Published: 2015
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44. Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone

Author: Kung, Pei-Pei, Sinnema, Piet-Jan, Richardson, Paul, Hickey, Michael J., Gajiwala, Ketan S., Wang, Fen, Huang, Buwen, McClellan, Guy, Wang, Jeff, Maegley, Karen, Bergqvist, Simon, Mehta, Pramod P., and Kania, Robert
Published: 2011
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45. RETRACTED: A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells

Author: Mehta, Pramod P., Kung, Pei-Pei, Yamazaki, Shinji, Walls, Marlena, Shen, Andrea, Nguyen, Leslie, Gehring, Michael R., Los, Gerrit, Smeal, Tod, and Yin, Min-Jean
Published: 2011
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46. Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Author: Kung, Pei-Pei, primary, Martinez, Ricardo, additional, Zhu, Zhou, additional, Zager, Michael, additional, Blasina, Alessandra, additional, Rymer, Isha, additional, Hallin, Jill, additional, Xu, Meirong, additional, Carroll, Christopher, additional, Chionis, John, additional, Wells, Peter, additional, Kozminski, Kirk, additional, Fan, Jeffery, additional, Guicherit, Oivin, additional, Huang, Buwen, additional, Cui, Mei, additional, Liu, Chaoting, additional, Huang, Zhongdong, additional, Sistla, Anand, additional, Yang, Jennifer, additional, and Murray, Brion W., additional
Published: 2014
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47. Rapid, microwave-assisted synthesis of N1-substituted 3-amino-1,2,4-triazoles

Author: Meng, Jerry and Kung, Pei-Pei
Published: 2009
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48. Synthesis of 6-substituted 2′-deoxyguanosine derivatives using trifluoroacetic anhydride in pyridine

Author: Goswami Bhaswati, Barbara L. Gaffney, Fathi Reza, Kung Pei-Pei, and Roger A. Jones
Subjects: Deoxyribonucleoside, chemistry.chemical_compound, Chemistry, Organic Chemistry, Drug Discovery, Pyridine, Deoxyguanosine, Organic chemistry, Trifluoroacetic anhydride, Biochemistry, Medicinal chemistry, Desoxyribonucleoside
Abstract: Trifluoroacetic anhydride at 0° C reacts with a pyridine suspension of deoxyguanosine to generate a polar intermediate, presumably the corresponding 6-pyridyl derivative. The reaction is complete in less than 15 minutes, and is not accompanied by degradation. From this intermediate a variety of 6-substituted deoxyguanosine derivatives can be obtained, some in excellent yields.
Published: 1990
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49. Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone

Author: Kung, Pei-Pei, Funk, Lee, Meng, Jerry, Collins, Michael, Zhou, Joe Zhongxiang, Catherine Johnson, M., Ekker, Anne, Wang, Jeff, Mehta, Pramod, Yin, Min-Jean, Rodgers, Caroline, Davies, Jay F., II, Bayman, Eileen, Smeal, Tod, Maegley, Karen A., and Gehring, Michael R.
Published: 2008
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50. Structure activity relationships of quinoline-containing c-Met inhibitors

Author: Kung, Pei-Pei, Funk, Lee, Meng, Jerry, Alton, Gordon, Padrique, Ellen, and Mroczkowski, Barbara
Published: 2008
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