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112 results on '"Kotte, A N T J"'

1. Free-Form Registration Involving Disappearing Structures: Application to Brachytherapy MRI

Author

Berendsen, Floris F., Kotte, Alexis N. T. J., de Leeuw, Astrid A. C., Viergever, Max A., Pluim, Josien P. W., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yoshida, Hiroyuki, editor, Warfield, Simon, editor, and Vannier, Michael W., editor

Published
2013
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2. Segmentation of Cervical Images by Inter-subject Registration with a Statistical Organ Model

Author

Berendsen, Floris F., van der Heide, Uulke A., Langerak, Thomas R., Kotte, Alexis N. T. J., Pluim, Josien P. W., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yoshida, Hiroyuki, editor, Sakas, Georgios, editor, and Linguraru, Marius George, editor

Published
2012
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3. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, Jürgenliemk-Schulz, Ina M, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, and Jürgenliemk-Schulz, Ina M

Published
2022

6. CTV-to-PTV margin assessment for esophageal cancer radiotherapy based on an accumulated dose analysis

Author

Fysica Radiotherapie Research, Cancer, MS CGO, Klinische Fysica RT, Onderzoek Beeld, MS Radiotherapie, Boekhoff, M R, Defize, I L, Borggreve, A S, van Hillegersberg, R, Kotte, A N T J, Lagendijk, J J W, van Lier, A L H M W, Ruurda, J P, Takahashi, N, Mook, S, Meijer, G J, Fysica Radiotherapie Research, Cancer, MS CGO, Klinische Fysica RT, Onderzoek Beeld, MS Radiotherapie, Boekhoff, M R, Defize, I L, Borggreve, A S, van Hillegersberg, R, Kotte, A N T J, Lagendijk, J J W, van Lier, A L H M W, Ruurda, J P, Takahashi, N, Mook, S, and Meijer, G J

Published
2021

9. Knowledge-Based Assessment of Focal Dose Escalation Treatment Plans in Prostate Cancer

Author

MS Radiotherapie, Klinische Fysica RT, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, van Schie, Marcel A, Janssen, Tomas M, Eekhout, Dave, Walraven, Iris, Pos, Floris J, de Ruiter, Peter, Kotte, Alexis N T J, Monninkhof, Evelyn M, Kerkmeijer, Linda G W, Draulans, Cédric, de Roover, Robin, Haustermans, Karin, Kunze-Busch, Martina, Smeenk, Robert Jan, van der Heide, Uulke A, MS Radiotherapie, Klinische Fysica RT, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, van Schie, Marcel A, Janssen, Tomas M, Eekhout, Dave, Walraven, Iris, Pos, Floris J, de Ruiter, Peter, Kotte, Alexis N T J, Monninkhof, Evelyn M, Kerkmeijer, Linda G W, Draulans, Cédric, de Roover, Robin, Haustermans, Karin, Kunze-Busch, Martina, Smeenk, Robert Jan, and van der Heide, Uulke A

Published
2020

10. Consensus on Contouring Primary Breast Tumors on MRI in the Setting of Neoadjuvant Partial Breast Irradiation in Trials

Author

Trialbureau Beeld, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Vasmel, Jeanine E, Groot Koerkamp, Maureen L, Kirby, Anna M, Russell, Nicola S, Shaitelman, Simona F, Vesprini, Danny, Anandadas, Carmel N, Currey, Adam, Keller, Brian M, Braunstein, Lior Z, Han, Kathy, Kotte, Alexis N T J, de Waard, Stephanie N, Philippens, Marielle E P, Houweling, Antonetta C, Verkooijen, Helena M, van den Bongard, H J G Desiree, Trialbureau Beeld, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Vasmel, Jeanine E, Groot Koerkamp, Maureen L, Kirby, Anna M, Russell, Nicola S, Shaitelman, Simona F, Vesprini, Danny, Anandadas, Carmel N, Currey, Adam, Keller, Brian M, Braunstein, Lior Z, Han, Kathy, Kotte, Alexis N T J, de Waard, Stephanie N, Philippens, Marielle E P, Houweling, Antonetta C, Verkooijen, Helena M, and van den Bongard, H J G Desiree

Published
2020

12. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, Nijkamp, Jasper, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, and Nijkamp, Jasper

Published
2019

13. Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

Author

Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., Spruit, P. H., Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., and Spruit, P. H.

Published
2019

14. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Klinische Fysica RT, Cancer, MS CGO, Arts-assistenten Radiotherapie, MS Radiologie, MS Radiotherapie, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, Nijkamp, Jasper, Klinische Fysica RT, Cancer, MS CGO, Arts-assistenten Radiotherapie, MS Radiologie, MS Radiotherapie, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, and Nijkamp, Jasper

Published
2019

15. Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

Author

Arts-assistenten Radiotherapie, Klinische Fysica RT, Cancer, Onderzoek Radiotherapie, MS Verloskunde, MS Mondziekten/Kaakchirurgie, MS Radiotherapie, Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., Spruit, P. H., Arts-assistenten Radiotherapie, Klinische Fysica RT, Cancer, Onderzoek Radiotherapie, MS Verloskunde, MS Mondziekten/Kaakchirurgie, MS Radiotherapie, Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., and Spruit, P. H.

Published
2019

16. Contouring of prostate tumors on multiparametric MRI : Evaluation of clinical delineations in a multicenter radiotherapy trial

Author

van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, van der Heide, Uulke A, van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, and van der Heide, Uulke A

Published
2018

17. Contouring of prostate tumors on multiparametric MRI: Evaluation of clinical delineations in a multicenter radiotherapy trial

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, van der Heide, Uulke A, MS Radiotherapie, Cancer, Klinische Fysica RT, van Schie, Marcel A, Dinh, Cuong V, Houdt, Petra J van, Pos, Floris J, Heijmink, Stijn W T J P, Kerkmeijer, Linda G W, Kotte, Alexis N T J, Oyen, Raymond, Haustermans, Karin, and van der Heide, Uulke A

Published
2018

19. First patients treated with a 1.5 T MRI-Linac: clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment

Author

Raaymakers, B W, primary, Jürgenliemk-Schulz, I M, additional, Bol, G H, additional, Glitzner, M, additional, Kotte, A N T J, additional, van Asselen, B, additional, de Boer, J C J, additional, Bluemink, J J, additional, Hackett, S L, additional, Moerland, M A, additional, Woodings, S J, additional, Wolthaus, J W H, additional, van Zijp, H M, additional, Philippens, M E P, additional, Tijssen, R, additional, Kok, J G M, additional, de Groot-van Breugel, E N, additional, Kiekebosch, I, additional, Meijers, L T C, additional, Nomden, C N, additional, Sikkes, G G, additional, Doornaert, P A H, additional, Eppinga, W S C, additional, Kasperts, N, additional, Kerkmeijer, L G W, additional, Tersteeg, J H A, additional, Brown, K J, additional, Pais, B, additional, Woodhead, P, additional, and Lagendijk, J J W, additional

Published
2017
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21. First patients treated with a 1.5 T MRI-Linac : Clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment

Author

Raaymakers, B W, Jürgenliemk-Schulz, I M, Bol, G H, Glitzner, M, Kotte, A N T J, van Asselen, B, de Boer, J C J, Bluemink, J J, Hackett, S L, Moerland, M A, Woodings, S J, Wolthaus, J W H, van Zijp, H M, Philippens, M E P, Tijssen, R, Kok, J G M, de Groot-van Breugel, E N, Kiekebosch, I, Meijers, L T C, Nomden, C.N., Sikkes, Gonda G, Doornaert, P A H, Eppinga, W S C, Kasperts, N, Kerkmeijer, L G W, Tersteeg, J H A, Brown, Kristy J., Pais, B, Woodhead, P, Lagendijk, J J W, Raaymakers, B W, Jürgenliemk-Schulz, I M, Bol, G H, Glitzner, M, Kotte, A N T J, van Asselen, B, de Boer, J C J, Bluemink, J J, Hackett, S L, Moerland, M A, Woodings, S J, Wolthaus, J W H, van Zijp, H M, Philippens, M E P, Tijssen, R, Kok, J G M, de Groot-van Breugel, E N, Kiekebosch, I, Meijers, L T C, Nomden, C.N., Sikkes, Gonda G, Doornaert, P A H, Eppinga, W S C, Kasperts, N, Kerkmeijer, L G W, Tersteeg, J H A, Brown, Kristy J., Pais, B, Woodhead, P, and Lagendijk, J J W

Published
2017

22. First patients treated with a 1.5 T MRI-Linac: Clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment

Author

Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Fysica Radiotherapie Research, Raaymakers, B W, Jürgenliemk-Schulz, I M, Bol, G H, Glitzner, M, Kotte, A N T J, van Asselen, B, de Boer, J C J, Bluemink, J J, Hackett, S L, Moerland, M A, Woodings, S J, Wolthaus, J W H, van Zijp, H M, Philippens, M E P, Tijssen, R, Kok, J G M, de Groot-van Breugel, E N, Kiekebosch, I, Meijers, L T C, Nomden, C.N., Sikkes, Gonda G, Doornaert, P A H, Eppinga, W S C, Kasperts, N, Kerkmeijer, L G W, Tersteeg, J H A, Brown, Kristy J., Pais, B, Woodhead, P, Lagendijk, J J W, Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Fysica Radiotherapie Research, Raaymakers, B W, Jürgenliemk-Schulz, I M, Bol, G H, Glitzner, M, Kotte, A N T J, van Asselen, B, de Boer, J C J, Bluemink, J J, Hackett, S L, Moerland, M A, Woodings, S J, Wolthaus, J W H, van Zijp, H M, Philippens, M E P, Tijssen, R, Kok, J G M, de Groot-van Breugel, E N, Kiekebosch, I, Meijers, L T C, Nomden, C.N., Sikkes, Gonda G, Doornaert, P A H, Eppinga, W S C, Kasperts, N, Kerkmeijer, L G W, Tersteeg, J H A, Brown, Kristy J., Pais, B, Woodhead, P, and Lagendijk, J J W

Published
2017

26. Patient position verification using small IMRT fields

Author

Bol, G. H., van der Heide, U. A., Nederveen, A. J., Kotte, A. N. T. J., Lagendijk, J. J. W., Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, and Radiology and Nuclear Medicine

Abstract

A commonly used approach to quantify and minimize patient setup errors is by using electronic portal imaging devices (EPIDs). The position of the tumor can be verified indirectly by matching the bony anatomy to a reference image containing the same structures. In this paper we present two off-line methods for detecting the position of the bony anatomy automatically, even if every single portal image of each segment of an IMRT treatment beam contains insufficient matching information. Extra position verification fields will no longer be necessary, which reduces the total dose to the patient. The first method, the stack matching method (SMM), stacks the portal image of each segment of a beam to a three dimensional (3D) volume, and this volume is subsequently used during the matching phase. The second method [the averaged projection matching method (APMM)], is a simplification of the first one, since the initially created volume is reduced again to a 2D artificial image, which speeds up the matching procedure considerably, without a significant loss of accuracy. Matching is based on normalized mutual information. We demonstrate our methods by comparing them to existing matching routines, such as matching based on the largest segment. Both phantom and patient experiments show that our methods are comparable with the results obtained from standard position verification methods. The matches are verified by means of visual inspection. Furthermore, we show that when a distinct area of 40-60 cm2 of the EPID is exposed during one treatment beam, both SMM and APMM are able to deliver a good matching result

Published
2006

27. Probabilistic treatment planning for pancreatic cancer treatment: prospective incorporation of respiratory motion shows only limited dosimetric benefit.

Author

Lens, Eelco, Kotte, Alexis N. T. J., Patel, Ajay, Heerkens, Hanne D., Bal, Matthieu, van Tienhoven, Geertjan, Bel, Arjan, van der Horst, Astrid, and Meijer, Gert J.

Subjects
*COMPUTED tomography, *DUODENUM, *LONGITUDINAL method, *MEDICAL protocols, *MOTION, *PANCREATIC tumors, *PROBABILITY theory, *RADIATION doses, *RADIATION measurements, *RADIATION dosimetry, *RESPIRATION, *RETROSPECTIVE studies, *DESCRIPTIVE statistics
Abstract

Background:We introduced a probabilistic treatment planning approach that prospectively incorporates respiratory-induced motion in the treatment plan optimization. The aim of this study was to determine the potential dosimetric benefit by comparing this approach to the use of an internal target volume (ITV). Material and method:We retrospectively compared the probabilistic respiratory motion-incorporated (RMI) approach to the ITV approach for 18 pancreatic cancer patients, for seven simulated respiratory amplitudes from 5 to 50 mm in the superior-inferior (SI) direction. For each plan, we assessed the target coverage (required: D98%≥95% of 50 Gy prescribed dose). For the RMI plans, we investigated whether target coverage was robust against daily variations in respiratory amplitude. We determined the distance between the clinical target volume and the 30 Gy isodose line (i.e. dose gradient steepness) in the SI direction. To investigate the clinical benefit of the RMI approach, we created for each patient an ITV and RMI treatment plan for the three-dimensional (3D) respiratory amplitudes observed on their pretreatment 4D computed tomography (4DCT). We determined Dmean, V30Gy, V40Gyand V50Gyfor the duodenum. Results:All treatment plans yielded good target coverage. The RMI plans were robust against respiratory amplitude variations up to 10 mm, as D98%remained ≥95%. We observed steeper dose gradients compared to the ITV approach, with a mean decrease from 25.9 to 19.2 mm for a motion amplitude of 50 mm. For the 4DCT motion amplitudes, the RMI approach resulted in a mean decrease of 0.43 Gy, 1.1 cm3, 1.4 cm3and 0.9 cm3for the Dmean, V30Gy, V40Gyand V50Gyof the duodenum, respectively. Conclusion:The probabilistic treatment planning approach yielded significantly steeper dose gradients and therefore significantly lower dose to surrounding healthy tissues than the ITV approach. However, the observed dosimetric gain for clinically observed respiratory motion amplitudes for this patient group was limited. [ABSTRACT FROM PUBLISHER]

Published
2017
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28. MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

Author

den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, van den Bongard, Hjg Desirée, den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, and van den Bongard, Hjg Desirée

Published
2014

29. MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

Author

Arts-assistenten Radiotherapie, Cancer, MS Radiotherapie, Other research (not in main researchprogram), MS Radiologie, Klinische Fysica RT, Trialbureau Beeld, Circulatory Health, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Divisie Beeld & Oncologie, Radiotherapie, den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, van den Bongard, Hjg Desirée, Arts-assistenten Radiotherapie, Cancer, MS Radiotherapie, Other research (not in main researchprogram), MS Radiologie, Klinische Fysica RT, Trialbureau Beeld, Circulatory Health, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Divisie Beeld & Oncologie, Radiotherapie, den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, and van den Bongard, Hjg Desirée

Published
2014

36. Post-lumpectomy CT-guided tumor bed delineation for breast boost and partial breast irradiation: Can additional pre- and postoperative imaging reduce interobserver variability?

Author

HARTOGH, MARISKA D. DEN, PHILIPPENS, MARIELLE E. P., VAN DAM, IRIS E., KLEYNEN, CATHARINA E., TERSTEEG, ROBBERT J.H.A., KOTTE, ALEXIS N. T. J., VAN VULPEN, MARCO, VAN ASSELEN, BRAM, and VAN DEN BONGARD, DESIRÉE H. J. G.

Subjects
LUMPECTOMY, LARGE-breasted women, MAMMOGRAMS, IRRADIATED foods, FOOD irradiation
Abstract

For breast boost radiotherapy or accelerated partial breast irradiation, the tumor bed (TB) is delineated by the radiation oncologist on a planning computed tomography (CT) scan. The aim of the present study was to investigate whether the interobserver variability (IOV) of the TB delineation is reduced by providing the radiation oncologist with additional magnetic resonance imaging (MRI) or CT scans. A total of 14 T1-T2 breast cancer patients underwent a standard planning CT in the supine treatment position following lumpectomy, as well as additional pre- and postoperative imaging in the same position. Post-lumpectomy TBs were independently delineated by four breast radiation oncologists on standard postoperative CT and on CT registered to an additional imaging modality. The additional imaging modalities used were postoperative MRI, preoperative contrast-enhanced (CE)-CT and preoperative CE-MRI. A cavity visualization score (CVS) was assigned to each standard postoperative CT by each observer. In addition, the conformity index (CI), volume and distance between centers of mass (dCOM) of the TB delineations were calculated. On CT, the median CI was 0.57, with a median volume of 22 cm3 and dCOM of 5.1 mm. The addition of postoperative MRI increased the median TB volume significantly to 28 cm3 (P<0.001), while the CI (P=0.176) and dCOM (P=0.110) were not affected. The addition of preoperative CT or MRI increased the TB volume to 26 and 25 cm3, respectively (both P<0.001), while the CI increased to 0.58 and 0.59 (both P<0.001) and the dCOM decreased to 4.7 mm (P=0.004) and 4.6 mm (P=0.001), respectively. In patients with CVS=3, the median CI was 0.40 on CT, which was significantly increased by all additional imaging modalities, up to 0.52, and was accompanied by a median volume increase up to 6 cm3. In conclusion, the addition of postoperative MRI, preoperative CE-CT or preoperative CE-MRI did not result in a considerable reduction in the IOV in postoperative CT-guided TB delineation, while target volumes marginally increased. The value of additional imaging may be dependent on CVS. [ABSTRACT FROM AUTHOR]

Published
2015
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43. Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy: analysis of a randomized clinical trial.

Author

den Harder, Annemarie M, van Gils, Carla H, Kotte, Alexis N T J, van Vulpen, Marco, and Lips, Irene M

Abstract

Purpose: To investigate whether magnesium oxide reduces the interfraction motion of the prostate and the amount of rectal filling and rectal gas, which influences prostate position during radiotherapy for prostate cancer.Patients and Methods: From December 2008 to February 2010, 92 prostate cancer patients scheduled for intensity-modulated radiotherapy (77 Gy in 35 fractions) using fiducial marker-based position verification were randomly assigned to receive magnesium oxide (500 mg twice a day) or placebo during radiotherapy. In a previous study, we investigated the effect on intrafraction motion and did not find a difference between the treatment arms. Here, we compared the interfraction prostate motion between the two treatment arms as well as the amount of rectal filling and rectal air pockets using pretreatment planning computed tomography and magnetic resonance imagingscans.Results: There was no statistically significant difference between the treatment arms in translation and rotation of the prostate between treatment fractions, except for the rotation around the cranial caudal axis. However, the difference was less than 1° and therefore considered not clinically relevant. There was no significant difference in the amount of rectal filling and rectal air pockets between the treatment arms.Conclusion: Magnesium oxide is not effective in reducing the interfraction prostate motion or the amount of rectal filling and rectal gas during external-beam radiotherapy. Therefore, magnesium oxide is not recommended in clinical practice for these purposes. [ABSTRACT FROM AUTHOR]

Published
2014
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44. MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy.

Author

den Hartogh, Mariska D., Philippens, Marielle E. P., van Dam, Iris E., Kleynen, Catharina E., Tersteeg, Robbert J. H. A., Pijnappel, Ruud M., Kotte, Alexis N. T. J., Verkooijen, Helena M., van den Bosch, Maurice A. A. J., van Vulpen, Marco, van Asselen, Bram, and van den Bongard, H. J. G. Desirée

Subjects
MAGNETIC resonance imaging, LUMPECTOMY, RADIOTHERAPY treatment planning, COMPUTED tomography, ONCOLOGISTS, TUMORS, PHYSIOLOGY
Abstract

Background Accurate tumor bed delineation after breast-conserving surgery is important. However, consistency among observers on standard postoperative radiotherapy planning CT is low and volumes can be large due to seroma formation. A preoperative delineation of the tumor might be more consistent. Therefore, the purpose of this study was to determine the consistency of preoperative target volume delineation on CT and MRI for breast-conserving radiotherapy. Methods Tumors were delineated on preoperative contrast-enhanced (CE) CT and newly developed 3D CE-MR images, by four breast radiation oncologists. Clinical target volumes (CTVs) were created by addition of a 1.5 cm margin around the tumor, excluding skin and chest wall. Consistency in target volume delineation was expressed by the interobserver variability. Therefore, the conformity index (CI), centre of mass distance (dCOM) and volumes were calculated. Tumor characteristics on CT and MRI were scored by an experienced breast radiologist. Results Preoperative tumor delineation resulted in a high interobserver agreement with a high median CI for the CTV, for both CT (0.80) and MRI (0.84). The tumor was missed on CT in 2/14 patients (14%). Leaving these 2 patients out of the analysis, CI was higher on MRI compared to CT for the GTV (p < 0.001) while not for the CTV (CT (0.82) versus MRI (0.84), p = 0.123). The dCOM did not differ between CT and MRI. The median CTV was 48 cm³ (range 28-137 cm³) on CT and 59 cm³ (range 30-153 cm³) on MRI (p < 0.001). Tumor shapes and margins were rated as more irregular and spiculated on CE-MRI. Conclusions This study showed that preoperative target volume delineation resulted in small target volumes with a high consistency among observers. MRI appeared to be necessary for tumor detection and the visualization of irregularities and spiculations. Regarding the tumor delineation itself, no clinically relevant differences in interobserver variability were observed. These results will be used to study the potential for future MRI-guided and neoadjuvant radiotherapy. Trial registration International Clinical Trials Registry Platform NTR3198 [ABSTRACT FROM AUTHOR]

Published
2014
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