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3. Impact of the COVID-19 pandemic on uveitis patient care

Author

Vu, Alexander F, Kodati, Shilpa, Lin, Phoebe, Bodaghi, Bahram, and Emami-Naeini, Parisa

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Vaccine Related, Clinical Research, Immunization, Infection, Good Health and Well Being, Humans, COVID-19, COVID-19 Vaccines, Pandemics, Cross-Sectional Studies, Uveitis, Patient Care, inflammation, eye, COVID-19 Practice Patterns Study Group, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Clinical sciences, Ophthalmology and optometry
Abstract

BackgroundThe COVID-19 pandemic has significantly changed practice of medicine and patient care worldwide. The impact of the pandemic on patients with uveitis is unknown. We developed the COVID-19 Practice Patterns Study Group to evaluate the effect of the pandemic on uveitis patient care.MethodsThis is a multicentre, cross-sectional survey of uveitis specialists practising worldwide. A web-based survey was distributed through the mailing lists of international uveitis societies to assess modifications in patient care, and use of immunomodulatory therapies (IMTs),aswell as considerations regarding COVID-19 vaccination.ResultsA diverse group consisting of 187 uveitis specialists from six continents participated in this survey. Most of these experts noted a disruption in clinical management of patients, including clinic closures or decrease in volume, patients missing in-person visits due to the fear of infection and difficulties obtaining laboratory testing. Most participants initiated (66.8%) and continued (93.3%) IMTs based on clinical presentation and did not modify their use of immunosuppressives. In cases of reported exposure to COVID-19 infection, most participants (65.3%) recommended no change in IMTs. However, 73.0% of the respondents did recommend holding all or select IMTs in case of COVID-19 infection. COVID-19 vaccine was recommended universally by almost all the specialists and 52% stated that they would counsel patients regarding the decreased immunogenicity and effectiveness of the vaccine in immunocompromised patients.ConclusionsUveitis patient care has changed significantly since the beginning of the pandemic. The recommendations will continue to evolve as new data on IMTs and vaccination become available.

Published
2023

9. Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies

Author

Stein, Sydney R., Ramelli, Sabrina C., Ramos-Benitez, Marcos J., Platt, Andrew P., Dickey, James M., Curran, Shelly J., Babyak, Ashley L., Valencia, Luis Perez, Richert, Mary E., Vannella, Kevin M., Chertow, Daniel S., Kleiner, David E., Hewitt, Stephen M., Young, Willie J., Young, Sarah P., Gasmi, Billel, De Melo, Michelly Sampaio, Desar, Sabina, Tadros, Saber, Nasir, Nadia, Jin, Xueting, Rajan, Sharika, Dikoglu, Esra, Ozkaya, Neval, Ylaya, Kris, Chung, Joon-Yong, Pittaluga, Stefania, Smith, Grace, Emanuel, Elizabeth R., Kelsall, Brian, Olivera, Justin A., Blawas, Megan, Grazioli, Alison, Hays, Nicole, Purcell, Madeleine, Singireddy, Shreya, Wu, Jocelyn, Raja, Katherine, Curto, Ryan, Chung, Jean, Borth, Amy, Bowers, Kimberly, Weichold, Anne, Minor, Paula, Moshref, Mirahmad, Kelly, Emily, Sajadi, Mohammad M., Scalea, Thomas M., Tran, Douglas, Madathil, Ronson J., Dahi, Siamak, Deatrick, Kristopher B., Krause, Eric M., Rabin, Joseph, Herrold, Joseph A., Tabatabai, Ali, Hochberg, Eric, Cornachione, Christopher, Levine, Andrea R., Saharia, Kapil K., Richards, Justin E., Elder, John, Burke, Allen, Mazzeffi, Michael A., Christenson, Robert, Chancer, Zackary, Abdulmahdi, Mustafa, Sopha, Sabrina, Goldberg, Tyler, Soherwardi, Shahabuddin, Sangwan, Yashvir, McCurdy, Michael T., Sudano, Kristen, Blume, Diane, Radin, Bethany, Arnouk, Madhat, Eagan, James W., Jr., Herr, Daniel L., Zerbe, Christa, Sen, H. Nida, Wang, Yujuan, Kodati, Shilpa, Lee, Jung Wha, Perez, Paola, Singh, Manmeet, Yinda, Kwe Claude, Platt, Andrew, Munster, Vincent J., de Wit, Emmie, Warner, Blake M., and Chan, Chi-Chao

Published
2023
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10. Ophthalmic Manifestations of ROSAH (Retinal Dystrophy, Optic Nerve Edema, Splenomegaly, Anhidrosis, and Headache) Syndrome, an Inherited NF κB–Mediated Autoinflammatory Disease with Retinal Dystrophy

Author

Huryn, Laryssa A., Kozycki, Christina Torres, Serpen, Jasmine Y., Zein, Wadih M., Ullah, Ehsan, Iannaccone, Alessandro, Williams, Lloyd B., Sobrin, Lucia, Brooks, Brian P., Sen, H. Nida, Hufnagel, Robert B., Kastner, Daniel L., and Kodati, Shilpa

Published
2023
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14. Bilateral Exudative Retinal Detachments and Panuveitis in a Patient with Multiple Myeloma.

Author

Nguyen, Nam V., Konstantinou, Eleni K., Sherif, Noha, Soifer, Matias, Patronas, Marena, Allen, Joshua, Bellur, Sunil S., and Kodati, Shilpa

Subjects
RETINAL detachment, OPTICAL coherence tomography, MULTIPLE myeloma, VISUAL acuity, SYMPTOMS, DIABETIC retinopathy
Abstract

Purpose: To report a case of bilateral exudative retinal detachments and panuveitis in a patient with multiple myeloma (MM). Case Report: A 54-year-old patient with non-proliferative diabetic retinopathy was referred with blurred vision and scotomas in both eyes (OU). Three months prior to the onset of ocular symptoms, he was diagnosed with systemic MM and was receiving chemotherapy. Clinical examination revealed best-corrected visual acuities of 20/80 OU, rare anterior chamber cell, 2+ vitreous cell, diffuse intraretinal hemorrhages, and exudative retinal detachments (RD). Optical coherence tomography of the macula showed central subretinal fluid with cystic intraretinal fluid OU. The findings were consistent with panuveitis and exudative RD in the setting of MM. He reported symptomatic improvement after plasmapheresis and oral prednisone initiation. Conclusion: Extensive, bilateral exudative RD and panuveitis are rare but potentially sight-threatening findings in patients with MM. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy

Author

Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Nath, Pulak R., Maclean, Mary, Nagarajan, Vijay, Lee, Jung Wha, Yakin, Mehmet, Kumar, Aman, Nadali, Hadi, Schmidt, Brian, Kaya, Koray D., Kodati, Shilpa, Young, Alice, Caspi, Rachel R., Kuiper, Jonas J.W., Sen, H. Nida, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Nath, Pulak R., Maclean, Mary, Nagarajan, Vijay, Lee, Jung Wha, Yakin, Mehmet, Kumar, Aman, Nadali, Hadi, Schmidt, Brian, Kaya, Koray D., Kodati, Shilpa, Young, Alice, Caspi, Rachel R., Kuiper, Jonas J.W., and Sen, H. Nida

Published
2024

18. Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.

Author

Nath, Pulak R., Maclean, Mary, Nagarajan, Vijay, Lee, Jung Wha, Yakin, Mehmet, Kumar, Aman, Nadali, Hadi, Schmidt, Brian, Kaya, Koray D., Kodati, Shilpa, Young, Alice, Caspi, Rachel R., Kuiper, Jonas J. W., and Sen, H. Nida

Subjects
KILLER cells, T cells, CELL receptors, CELLULAR recognition, CELL populations
Abstract

Birdshot chorioretinopathy is an inflammatory eye condition strongly associated with MHC-I allele HLA-A29. The striking association with MHC-I suggests involvement of T cells, whereas natural killer (NK) cell involvement remains largely unstudied. Here we show that HLA-A29-positive birdshot chorioretinopathy patients have a skewed NK cell pool containing expanded CD16 positive NK cells which produce more proinflammatory cytokines. These NK cells contain populations that express CD8A which is involved in MHC-I recognition on target cells, display gene signatures indicative of high cytotoxic activity (GZMB, PRF1 and ISG15), and signaling through NK cell receptor CD244 (SH2D1B). Long-term monitoring of a cohort of birdshot chorioretinopathy patients with active disease identifies a population of CD8bright CD244bright NK cells, which rapidly declines to normal levels upon clinical remission following successful treatment. Collectively, these studies implicate CD8bright CD244bright NK cells in birdshot chorioretinopathy. Birdshot chorioretinopathy is an inflammatory eye condition strongly associated with HLA-A29. Here the authors use a single cell RNA sequencing approach to characterise NK cell involvement in this disease and show that CD8bright CD244bright NK cells are associated with active disease. [ABSTRACT FROM AUTHOR]

Published
2024
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25. ROLE OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN DETECTING AND MONITORING INFLAMMATORY CHOROIDAL NEOVASCULARIZATION

Author

Kongwattananon, Wijak, Grasic, David, Lin, Henry, Oyeniran, Enny, Sen, H Nida, and Kodati, Shilpa

Subjects
Ophthalmology, Choroid, Visual Acuity, Humans, General Medicine, Fluorescein Angiography, Article, Choroidal Neovascularization, Tomography, Optical Coherence
Abstract

To investigate the utility of optical coherence tomography angiography (OCTA) for the detection of inflammatory choroidal neovascularization (iCNV) and monitoring their response to treatment.A retrospective review of patients with a diagnosis of uveitis and associated iCNV with active exudation was performed. Active iCNV was determined by spectral domain OCT and/or fluorescein angiogram. Spectral domain OCTA outer retina to choriocapillaris slabs was evaluated for the presence of iCNV. Follow-up OCTA images were qualitatively assessed to determine whether regression of iCNV occurred after treatment.Thirteen eyes of 12 patients were included. The etiologies of uveitis include punctate inner choroidopathy (n = 4), multifocal choroiditis (n = 2), presumed sarcoid uveitis (n = 2), tuberculous choroiditis (n = 1), birdshot chorioretinopathy (n = 1), syphilitic uveitis (n = 1), serpiginous choroiditis (n = 1), and idiopathic panuveitis (n = 1). Inflammatory choroidal neovascularization was detected on en face OCTA in 10 of 13 eyes (76.9%). After iCNV treatment, en face OCTA demonstrated complete regression of iCNV in 5 of 10 eyes (50%), partial regression in 2 of 10 eyes (20%), and no regression in 3 of 10 eyes (30%).Optical coherence tomography angiography is an effective modality for detecting iCNV and could provide detailed visualization regarding location, morphologic structure, and flow of the iCNV and its response to therapy.

Published
2022
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27. Histopathology and SARS-CoV-2 cellular localization in eye tissues of COVID-19 autopsies

Author

Sen, H. Nida, primary, Vannella, Kevin M., additional, Wang, Yujuan, additional, Chung, Joon-Yong, additional, Kodati, Shilpa, additional, Ramelli, Sabrina C., additional, Lee, Jung Wha, additional, Perez, Paola, additional, Stein, Sydney R., additional, Grazioli, Alison, additional, Dickey, James M., additional, Ylaya, Kris, additional, Singh, Manmeet, additional, Yinda, Kwe Claude, additional, Platt, Andrew, additional, Ramos-Benitez, Marcos J., additional, Zerbe, Christa, additional, Munster, Vincent J., additional, de Wit, Emmie, additional, Warner, Blake M, additional, Herr, Daniel L., additional, Rabin, Joseph, additional, Saharia, Kapil K, additional, Kleiner, David E., additional, Hewitt, Stephen M., additional, Chan, Chi-Chao, additional, Chertow, Daniel S., additional, Platt, Andrew P., additional, Curran, Shelly J., additional, Babyak, Ashley L., additional, Valencia, Luis Perez, additional, Richert, Mary E., additional, Young, Willie J., additional, Young, Sarah P., additional, Gasmi, Billel, additional, De Melo, Michelly Sampaio, additional, Desar, Sabina, additional, Tadros, Saber, additional, Nasir, Nadia, additional, Jin, Xueting, additional, Rajan, Sharika, additional, Dikoglu, Esra, additional, Ozkaya, Neval, additional, Pittaluga, Stefania, additional, Smith, Grace, additional, Emanuel, Elizabeth R., additional, Kelsall, Brian, additional, Olivera, Justin A., additional, Blawas, Megan, additional, Hays, Nicole, additional, Purcell, Madeleine, additional, Singireddy, Shreya, additional, Wu, Jocelyn, additional, Raja, Katherine, additional, Curto, Ryan, additional, Chung, Jean, additional, Borth, Amy, additional, Bowers, Kimberly, additional, Weichold, Anne, additional, Minor, Paula, additional, Moshref, Mirahmad, additional, Kelly, Emily, additional, Sajadi, Mohammad M., additional, Scalea, Thomas M., additional, Tran, Douglas, additional, Madathil, Ronson J., additional, Dahi, Siamak, additional, Deatrick, Kristopher B., additional, Krause, Eric M., additional, Herrold, Joseph A., additional, Tabatabai, Ali, additional, Hochberg, Eric, additional, Cornachione, Christopher, additional, Levine, Andrea R., additional, Saharia, Kapil K., additional, Richards, Justin E., additional, Elder, John, additional, Burke, Allen, additional, Mazzeffi, Michael A., additional, Christenson, Robert, additional, Chancer, Zackary, additional, Abdulmahdi, Mustafa, additional, Sopha, Sabrina, additional, Goldberg, Tyler, additional, Soherwardi, Shahabuddin, additional, Sangwan, Yashvir, additional, McCurdy, Michael T., additional, Sudano, Kristen, additional, Blume, Diane, additional, Radin, Bethany, additional, Arnouk, Madhat, additional, and Eagan, James W., additional

Published
2023
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32. Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.

Author

Nath, Pulak, primary, Maclean, Mary, additional, Nagarajan, Vijay, additional, Lee, Jung, additional, Yakin, Mehmet, additional, Kumar, Aman, additional, Nadali, Hadi, additional, Schmidt, Brian, additional, Kaya, Koray Dogan, additional, Kodati, Shilpa, additional, Young, Alice, additional, Caspi, Rachel, additional, Kuiper, Jonas, additional, and Sen, Nida, additional

Published
2022
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35. Single-cell profiling identifies a CD8brightCD244brightNatural Killer cell subset that reflects disease activity in HLA-A29-positivebirdshot chorioretinopathy

Author

Nath, Pulak R., primary, Maclean, Mary, additional, Nagarajan, Vijay, additional, Lee, Jung Wha, additional, Yakin, Mehmet, additional, Kumar, Aman, additional, Nadali, Hadi, additional, Schmidt, Brian, additional, Kaya, Koray D., additional, Kodati, Shilpa, additional, Young, Alice, additional, Caspi, Rachel R., additional, Kuiper, Jonas J. W., additional, and Sen, H. Nida, additional

Published
2022
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36. Bilateral Acute Macular Neuroretinopathy after COVID-19 Vaccination and Infection.

Author

Bellur, Sunil, Zeleny, Alexander, Patronas, Marena, Jiramongkolchai, Kim, and Kodati, Shilpa

Subjects
COVID-19, COVID-19 vaccines, OPTICAL coherence tomography, SYMPTOMS, VISION disorders
Abstract

To describe a case of acute macular neuroretinopathy (AMN) in a patient with recent COVID-19 vaccination and infection who demonstrated atypical features on presentation. A 64-year-old woman presented with central vision loss in both eyes (OU). She had recently received the Moderna COVID-19 vaccine and rapidly developed systemic symptoms. Testing revealed COVID-19 infection. Visual acuities were 20/200 OU and near-infrared reflectance revealed hypo-reflective lesions in the maculae OU, optical coherence tomography (OCT) showed outer nuclear layer thinning and ellipsoid zone disruption OU, and OCT-angiography showed flow voids in the deep capillary plexus and choriocapillaris OU, all consistent with AMN. She was treated with oral prednisone with subsequent mild vision improvement and persistent scotomas. COVID-19 associated AMN can present with a more severe clinical presentation than classically seen in AMN. Ischemic and inflammatory changes due to COVID-19 infection may contribute to this more advanced presentation. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Gain-of-function mutations inALPK1cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome

Author

Kozycki, Christina Torres, primary, Kodati, Shilpa, additional, Huryn, Laryssa, additional, Wang, Hongying, additional, Warner, Blake M, additional, Jani, Priyam, additional, Hammoud, Dima, additional, Abu-Asab, Mones S, additional, Jittayasothorn, Yingyos, additional, Mattapallil, Mary J, additional, Tsai, Wanxia Li, additional, Ullah, Ehsan, additional, Zhou, Ping, additional, Tian, Xiaoying, additional, Soldatos, Ariane, additional, Moutsopoulos, Niki, additional, Kao-Hsieh, Marie, additional, Heller, Theo, additional, Cowen, Edward W, additional, Lee, Chyi-Chia Richard, additional, Toro, Camilo, additional, Kalsi, Shelley, additional, Khavandgar, Zohreh, additional, Baer, Alan, additional, Beach, Margaret, additional, Long Priel, Debra, additional, Nehrebecky, Michele, additional, Rosenzweig, Sofia, additional, Romeo, Tina, additional, Deuitch, Natalie, additional, Brenchley, Laurie, additional, Pelayo, Eileen, additional, Zein, Wadih, additional, Sen, Nida, additional, Yang, Alexander H, additional, Farley, Gary, additional, Sweetser, David A, additional, Briere, Lauren, additional, Yang, Janine, additional, de Oliveira Poswar, Fabiano, additional, Schwartz, Ida Vanessa D, additional, Silva Alves, Tamires, additional, Dusser, Perrine, additional, Koné-Paut, Isabelle, additional, Touitou, Isabelle, additional, Titah, Salah Mohamed, additional, van Hagen, Petrus Martin, additional, van Wijck, Rogier T A, additional, van der Spek, Peter J, additional, Yano, Hiromi, additional, Benneche, Andreas, additional, Apalset, Ellen M, additional, Jansson, Ragnhild Wivestad, additional, Caspi, Rachel R, additional, Kuhns, Douglas Byron, additional, Gadina, Massimo, additional, Takada, Hidetoshi, additional, Ida, Hiroaki, additional, Nishikomori, Ryuta, additional, Verrecchia, Elena, additional, Sangiorgi, Eugenio, additional, Manna, Raffaele, additional, Brooks, Brian P, additional, Sobrin, Lucia, additional, Hufnagel, Robert B, additional, Beck, David, additional, Shao, Feng, additional, Ombrello, Amanda K, additional, Aksentijevich, Ivona, additional, and Kastner, Daniel L, additional

Published
2022
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43. Isolated Optic Disc Granuloma as a Presenting Sign of Sarcoidosis.

Author

Oyeniran, Enny, Katz, David, and Kodati, Shilpa

Subjects
SARCOIDOSIS, OPTIC disc, GRANULOMA, OPTIC disc edema, POSITRON emission tomography, EYE inflammation
Abstract

To report a case of an optic disc granuloma secondary to sarcoidosis in the absence of any systemic symptoms nor evident signs of intraocular inflammation at the time of presentation. Retrospective case report A 59-year-old Caucasian woman with previously unrevealing systemic work up was referred to the uveitis service for persistent optic disc edema of the right eye for over 1 year. Fundoscopic examination revealed an optic disc granuloma with associated hyper-reflectivity on OCT and high surface reflectivity with medium internal reflectivity on B-scan ultrasound. CT chest was negative, however, a PET scan demonstrated extensive FDG activity in the mediastinum and bilateral hilum, consistent with a diagnosis of sarcoidosis. Optic nerve head granulomas can rarely present as the only clinical sign of sarcoidosis. In these cases, additional imaging modalities may be needed to make the appropriate diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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