Search

Your search keyword '"Kobayashi, Sayo"' showing total 50 results
Start Over Author "Kobayashi, Sayo" Publication Year Range Last 50 years
50 results on '"Kobayashi, Sayo"'

1. Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, Matsueda, Kazuhiro, Yoshioka, Masao, Miyahara, Koji, Sakaguchi, Chihiro, Nishimura, Mamoru, Nagahara, Teruya, Mannami, Tomohiko, Takenaka, Ryuta, Oka, Shohei, Inoue, Masafumi, Takimoto, Hidetaka, Inaba, Tomoki, Kobayashi, Sayo, Toyokawa, Tatsuya, Tsugeno, Hirofumi, Suzuki, Seiyuu, Sawada, Sachiko, Tanaka, Shouichi, Tsuzuki, Takao, and Okada, Hiroyuki

Published
2023
Full Text
View/download PDF

5. Lesion size, elevated morphology, and non or closed-type atrophy are predictive factors for gastric adenocarcinoma of the fundic gland type rather than oxyntic gland adenoma

Author

Iwamuro, Masaya, Kusumoto, Chiaki, Nakagawa, Masahiro, Matsueda, Kazuhiro, Kobayashi, Sayo, Yoshioka, Masao, Inaba, Tomoki, Toyokawa, Tatsuya, Sakaguchi, Chihiro, Tanaka, Shouichi, Tanaka, Takehiro, and Okada, Hiroyuki

Subjects
oxyntic gland adenoma, Gastric adenocarcinoma of the fundic gland type (GA-FG), Oncology, gastric neoplasms, submucosal invasion, Gastroenterology
Abstract

Background: An oxyntic gland neoplasm confined to the mucosal layer (T1a) is classified as an oxyntic gland adenoma, whereas that with submucosal invasion (T1b) is defined as gastric adenocarcinoma of the fundic gland type (GA-FG). Methods: To reveal the differences in clinical features between them, we retrospectively investigated 136 patients with 150 oxyntic gland adenoma and GA-FG lesions. Results: The univariate analysis revealed that the mean size (GA-FG vs. oxyntic gland adenoma, 7.7±5.4 vs. 5.5±3.1 mm), the prevalence of elevated morphology (79.1% vs. 51.8%), black pigmentation within the lesion (23.9% vs. 9.6%), and non or closed-type atrophy (81.2% vs. 65.1%) were different between the two groups. A multivariate logistic regression analysis revealed that ≥5 mm lesion size (odds ratio, 2.96; 95% confidence interval: 1.21–7.23), elevated morphology (odds ratio, 2.40; 95% confidence interval: 1.06–5.45), and no or closed-type atrophy (odds ratio, 2.49; 95% confidence interval: 1.07–5.80) were factors in distinguishing GA-FG from oxyntic gland adenoma. When oxyntic gland neoplasms with no or one feature were judged as oxyntic gland adenomas and those with two or three features were judged as GA-FG, the sensitivity and specificity were 85.1% and 43.4% for GA-FG, respectively. Conclusions: We identified three possible distinctive features of GA-FG compared to oxyntic gland adenoma: lesion size ≥5 mm, elevated morphology, and no or closed-type atrophy.

Published
2023

6. Current prognostic factors of advanced gastric cancer patients treated with chemotherapy: real world data from a Japanese 12 institutions

Author

Yamamoto, Shumpei, primary, Kanzaki, Hiromitsu, additional, Sakaguchi, Chihiro, additional, Mouri, Hirokazu, additional, Tsuzuki, Takao, additional, Nasu, Junichiro, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Obayashi, Yuka, additional, Inoue, Masafumi, additional, Kato, Ryo, additional, Matsubara, Minoru, additional, Kita, Masahide, additional, and Okada, Hiroyuki, additional

Published
2023
Full Text
View/download PDF

7. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

9. Pancreatic Exocrine Insufficiency in Intraductal Papillary Mucinous Carcinoma Presenting with Leg Edema Treated with Pancreatic Exocrine Replacement Therapy

Author

Tanaka, Emi, Ogawa, Tsuneyoshi, Tsutsumi, Koichiro, Kobayashi, Sayo, Nawa, Toru, Ueki, Toru, Okada, Hiroyuki, Tanaka, Emi, Ogawa, Tsuneyoshi, Tsutsumi, Koichiro, Kobayashi, Sayo, Nawa, Toru, Ueki, Toru, and Okada, Hiroyuki

Abstract

An 89-year-old woman underwent examinations for leg edema. Blood tests indicated low nutrition and low pancreatic enzymes, and a stool examination indicated fatty stool. Computed tomography showed pleural effusion, ascites, and cystic lesions in the pancreatic head and mural nodules within the cysts. Pancreatic juice cytology revealed adenocarcinoma. The diagnosis was pancreatic exocrine insufficiency caused by intraductal papillary mucinous carcinoma. The patient did not wish to undergo surgery. Therefore, diuretics, component nutrients, and pancreatic exocrine replacement therapy using pancrelipase were initiated. After starting treatment, her leg edema, pleural effusion, and ascites disappeared, and her activities of daily living improved markedly.

Published
2022

11. Additional file 1 of Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type differ between patients with and without Helicobacter pylori infection: a retrospective observational study

Author

Iwamuro, Masaya, Kusumoto, Chiaki, Nakagawa, Masahiro, Matsueda, Kazuhiro, Kobayashi, Sayo, Yoshioka, Masao, Inaba, Tomoki, Toyokawa, Tatsuya, Sakaguchi, Chihiro, Tanaka, Shouichi, Tanaka, Takehiro, and Okada, Hiroyuki

Abstract

Additional file 1. Table S1. Comparison of the active and inactive gastritis groups.

Published
2022
Full Text
View/download PDF

12. Endoscopic Features of Oxyntic Gland Adenoma and Gastric Adenocarcinoma of the Fundic Gland Type Differ Between Patients with and Without Helicobacter pylori Infection: A Retrospective Observational Study

Author

Iwamuro, Masaya, primary, Kusumoto, Chiaki, additional, Nakagawa, Masahiro, additional, Matsueda, Kazuhiro, additional, Kobayashi, Sayo, additional, Yoshioka, Masao, additional, Inaba, Tomoki, additional, Toyokawa, Tatsuya, additional, Sakaguchi, Chihiro, additional, Tanaka, Shouichi, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2022
Full Text
View/download PDF

15. Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer

Author

Nouso, Kazuhiro, Amano, Maho, Ito, Yoichi M., Miyahara, Koji, Morimoto, Yuki, Kato, Hironari, Tsutsumi, Koichiro, Tomoda, Takeshi, Yamamoto, Naoki, Nakamura, Shinichiro, Kobayashi, Sayo, Kuwaki, Kenji, Hagihara, Hiroaki, Onishi, Hideki, Miyake, Yasuhiro, Ikeda, Fusao, Shiraha, Hidenori, Takaki, Akinobu, Nakahara, Taku, Nishimura, Shin-Ichiro, and Yamamoto, Kazuhide

Published
2013
Full Text
View/download PDF

16. A prospective multicenter study of the magnifying endoscopic evaluation of the invasion depth of superficial esophageal cancers

Author

Gotoda, Tatsuhiro, primary, Hori, Keisuke, additional, Nakagawa, Masahiro, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Ishiyama, Shuhei, additional, Imagawa, Atsushi, additional, Abe, Makoto, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, and Okada, Hiroyuki, additional

Published
2021
Full Text
View/download PDF

17. Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer: A multicenter retrospective study

Author

Satomi, Takuya, Kawano, Seiji, Inaba, Tomoki, Nakagawa, Masahiro, Mouri, Hirokazu, Yoshioka, Masao, Tanaka, Shoichi, Toyokawa, Tatsuya, Kobayashi, Sayo, Tanaka, Takehiro, Kanzaki, Hiromitsu, Iwamuro, Masaya, Kawahara, Yoshiro, Okada, Hiroyuki, Satomi, Takuya, Kawano, Seiji, Inaba, Tomoki, Nakagawa, Masahiro, Mouri, Hirokazu, Yoshioka, Masao, Tanaka, Shoichi, Toyokawa, Tatsuya, Kobayashi, Sayo, Tanaka, Takehiro, Kanzaki, Hiromitsu, Iwamuro, Masaya, Kawahara, Yoshiro, and Okada, Hiroyuki

Abstract

BACKGROUND Recent improvements in the prognosis of patients with esophageal cancer have led to the increased occurrence of gastric tube cancer (GTC) in the reconstructed gastric tube. However, there are few reports on the treatment results of endoscopic submucosal dissection (ESD) for GTC. AIM To evaluate the efficacy and safety of ESD for GTC after esophagectomy in a multicenter trial. METHODS We retrospectively investigated 48 GTC lesions in 38 consecutive patients with GTC in the reconstructed gastric tube after esophagectomy who had undergone ESD between January 2005 and December 2019 at 8 institutions participating in the Okayama Gut Study group. The clinical indications of ESD for early gastric cancer were similarly applied for GTC after esophagectomy. ESD specimens were evaluated in 2-mm slices according to the Japanese Classification of Gastric Carcinoma with curability assessments divided into curative and non-curative resection based on the Gastric Cancer Treatment Guidelines. Patient characteristics, treatment results, clinical course, and treatment outcomes were analyzed. RESULTS The median age of patients was 71.5 years (range, 57-84years), and there were 34 men and 4 women. The median observation period after ESD was 884 d (range, 8-4040 d). The median procedure time was 81 min (range, 29-334 min), the en bloc resection rate was 91.7% (44/48), and the curative resection rate was 79% (38/48). Complications during ESD were seen in 4% (2/48) of case, and those after ESD were seen in 10% (5/48) of case. The survival rate at 5 years was 59.5%. During the observation period after ESD, 10 patients died of other diseases. Although there were differences in the procedure time between institutions, a multivariate analysis showed that tumor size was the only factor associated with prolonged procedure time. CONCLUSION ESD for GTC after esophagectomy was shown to be safe and effective.

Published
2021

18. Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer: A multicenter retrospective study

Author

Satomi, Takuya, primary, Kawano, Seiji, additional, Inaba, Tomoki, additional, Nakagawa, Masahiro, additional, Mouri, Hirokazu, additional, Yoshioka, Masao, additional, Tanaka, Shoichi, additional, Toyokawa, Tatsuya, additional, Kobayashi, Sayo, additional, Tanaka, Takehiro, additional, Kanzaki, Hiromitsu, additional, Iwamuro, Masaya, additional, Kawahara, Yoshiro, additional, and Okada, Hiroyuki, additional

Published
2021
Full Text
View/download PDF

19. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, Okada, Hiroyuki, Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, and Okada, Hiroyuki

Abstract

Objective Gastric endoscopic submucosal dissection (ESD) under heparin replacement (HR) of warfarin reportedly has a high risk of delayed bleeding (24-57%). It is possible that the delayed bleeding risk may have changed over the years. We evaluated the current risk of delayed bleeding after gastric ESD under HR of anticoagulant agents. Methods We retrospectively reviewed the delayed bleeding rate and analyzed the risk factors for delayed bleeding. Patients Consecutive patients who underwent gastric ESD under HR of anticoagulant agents from July 2015 to June 2017. Results A total of 32 patients with a solitary early gastric cancer and taking anticoagulant agents were analyzed, including 24 patients on warfarin (the warfarin group) and 8 patients on direct oral anticoagulants (the DOAC group). Three (9.4%) patients experienced delayed bleeding: three (12.5%) patients in the warfarin group and no patients in the DOAC group. Continued aspirin treatment was identified to be a risk factor of delayed bleeding (p=0.01). Conclusion Careful management may be required for patients undergoing gastric ESD under continued aspirin treatment in addition to HR of anticoagulant agents; although the delayed bleeding risk after gastric ESD under HR of anticoagulant agents might have decreased over the years.

Published
2020

27. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, primary, Kanzaki, Hiromitsu, additional, Inoue, Masafumi, additional, Ishiyama, Shuhei, additional, Yamauchi, Kenji, additional, Miyahara, Koji, additional, Toyokawa, Tatsuya, additional, Tsuzuki, Takao, additional, Miyaike, Jiro, additional, Matsubara, Minoru, additional, Takahashi, Sakuma, additional, Nishimura, Mamoru, additional, Takenaka, Ryuta, additional, Yunoki, Naoko, additional, Hori, Shinichiro, additional, Kobayashi, Sayo, additional, Yamasaki, Yasushi, additional, Kawahara, Yoshiro, additional, Ishikawa, Hideki, additional, and Okada, Hiroyuki, additional

Published
2020
Full Text
View/download PDF

28. Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors

Author

Iwamuro, Masaya, primary, Miyahara, Koji, additional, Sakaguchi, Chihiro, additional, Takenaka, Ryuta, additional, Kobayashi, Sayo, additional, Mouri, Hirokazu, additional, Tanaka, Shigetomi, additional, Toyokawa, Tatsuya, additional, Tanaka, Shouichi, additional, Nishimura, Mamoru, additional, Yamauchi, Kenji, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2020
Full Text
View/download PDF

29. Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp

Author

Iwamuro, Masaya, primary, Aoyama, Yuki, additional, Suzuki, Seiyuu, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Moritou, Yuki, additional, Hori, Shinichiro, additional, Matsueda, Kazuhiro, additional, Yoshioka, Masao, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2019
Full Text
View/download PDF

30. Mo1174 CLINICOPATHOLOGICAL CHARACTERISTICS AND RISK FACTORS FOR METASTASIS OF SUPERFICIAL BARRETT'S ADENOCARCINOMA:A MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY

Author

Mouri, Hirokazu, primary, Mizuno, Motowo, additional, Hamada, Kenta, additional, Kanzaki, Hiromitsu, additional, Okada, Hiroyuki, additional, Takahashi, Sakuma, additional, Nasu, Junichiro, additional, Miyaike, Jiro, additional, Yamauchi, Kenji, additional, Takenaka, Ryuta, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Inoue, Masafumi, additional, Nishimura, Mamoru, additional, Matubara, Minoru, additional, and Tomoda, Jun, additional

Published
2019
Full Text
View/download PDF

31. Adenocarcinoma In Situ Arising from Brunner’s Gland Treated by Endoscopic Mucosal Resection

Author

Iwamuro, Masaya, Kobayashi, Sayo, Ohara, Nobuya, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Subjects
Article Subject, digestive system, digestive system diseases
Abstract

An 86-year-old Japanese man was presented to our hospital for further investigation of duodenal adenocarcinoma. The tumor was endoscopically resected. Pathological analysis revealed coexistence of gastric foveolar metaplasia and a surrounding hyperplastic Brunner’s gland, in addition to an adenocarcinoma component. Immunostaining for MUC5AC and MUC6 confirmed the diagnosis of adenocarcinoma in situ arising from Brunner’s gland hyperplasia. This case suggests that although detailed preoperative evaluation is required to determine the depth of tumor invasion, endoscopic resection may be a promising option for the treatment of adenocarcinomas arising from Brunner’s gland hyperplasia.

Published
2017
Full Text
View/download PDF

33. Serum Glycan Markers for Evaluation of Disease Activity and Prediction of Clinical Course in Patients with Ulcerative Colitis

Author

Miyahara, Koji, primary, Nouso, Kazuhiro, additional, Saito, Shunsuke, additional, Hiraoka, Sakiko, additional, Harada, Keita, additional, Takahashi, Sakuma, additional, Morimoto, Yuki, additional, Kobayashi, Sayo, additional, Ikeda, Fusao, additional, Miyake, Yasuhiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Okada, Hiroyuki, additional, Amano, Maho, additional, Hirose, Kazuko, additional, Nishimura, Shin-Ichiro, additional, and Yamamoto, Kazuhide, additional

Published
2013
Full Text
View/download PDF

35. Tu1101 Stage I and II Follicular Lymphoma With Gastrointestinal Involvement: Long-Term Follow-up of No Initial Therapy

Author

Okada, Hiroyuki, primary, Takata, Katsuyoshi, additional, Kawahara, Yoshiro, additional, Nasu, Junichiro, additional, Kawano, Seiji, additional, Kita, Masahide, additional, Tsuzuki, Takao, additional, Matubara, Minoru, additional, Hori, Keisuke, additional, Kanzaki, Hiromitu, additional, Kobayashi, Sayo, additional, Yoshino, Tadashi, additional, and Yamamoto, Kazuhide, additional

Published
2013
Full Text
View/download PDF

36. Sa1096 Efficacy and Long-Term Follow-up of Helicobacter pylori Eradication Therapy and Radiation Therapy as a Secondary Treatment for Localized Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Author

Okada, Hiroyuki, primary, Kawahara, Yoshiro, additional, Nasu, Junichiro, additional, Kawano, Seiji, additional, Tsuzuki, Takao, additional, Kita, Masahide, additional, Matubara, Minoru, additional, Hori, Keisuke, additional, Kobayashi, Sayo, additional, Kawai, Daisuke, additional, Tanaka, Takehiro, additional, Yoshino, Tadashi, additional, and Yamamoto, Kazuhide, additional

Published
2012
Full Text
View/download PDF

38. Stage I and II Follicular Lymphoma With Gastrointestinal Involvement: Long-Term Follow-up of No Initial Therapy

Author

Okada, Hiroyuki, primary, Takata, Katsuyoshi, additional, Kawahara, Yoshiro, additional, Inoue, Masahumi, additional, Kawano, Seiji, additional, Tsuzuki, Takao, additional, Kita, Masahide, additional, Hori, Keisuke, additional, Kawai, Daisuke, additional, Kobayashi, Sayo, additional, Nasu, Junichiro, additional, Yoshino, Tadashi, additional, and Yamamoto, Kazuhide, additional

Published
2011
Full Text
View/download PDF

40. Mo1570 Endoscopic and Histopathological Changes After Helicobacter Pylori Eradication Therapy in Patients With Gastric MALT Lymphoma

Author

Okada, Hiroyuki, primary, Kawahara, Yoshiro, additional, Kawano, Seiji, additional, Inoue, Masahumi, additional, Nasu, Junichiro, additional, Tsuzuki, Takao, additional, Kita, Masahide, additional, Hori, Keisuke, additional, Kawai, Daisuke, additional, Kobayashi, Sayo, additional, and Yamamoto, Kazuhide, additional

Published
2011
Full Text
View/download PDF

42. A case of hepatocellular carcinoma with skin injury of the upper abdominal wall after transcatheter arterial chemoembolization: a case report

Author

Kanzaki, Hiromitsu, primary, Nouso, Kazuhiro, additional, Miyahara, Koji, additional, Kajikawa, Naoko, additional, Kobayashi, Sayo, additional, Sakakihara, Ichiro, additional, Iwadow, Shota, additional, Uematsu, Shuji, additional, Okamoto, Ryoichi, additional, Shiraga, Kunihiro, additional, Mizuno, Motowo, additional, and Araki, Yasuyuki, additional

Published
2009
Full Text
View/download PDF

44. Rates and risk factors of bleeding after gastric endoscopic submucosal dissection with continuous warfarin or 1‐day withdrawal of direct oral anticoagulants.

Author

Hirata, Shoichiro, Hamada, Kenta, Iwamuro, Masaya, Mouri, Hirokazu, Miyahara, Koji, Tsuzuki, Takao, Yamauchi, Kenji, Kobayashi, Sayo, Takahashi, Sakuma, Takenaka, Ryuta, Hori, Shinichiro, Inoue, Masafumi, Toyokawa, Tatsuya, Nishimura, Mamoru, Ishiyama, Shuhei, Miyaike, Jiro, Kato, Ryo, Matsubara, Minoru, Yunoki, Naoko, and Kanzaki, Hiromitsu

Subjects
*ORAL medication, *PLATELET aggregation inhibitors, *WARFARIN, *ANTICOAGULANTS, *STOMACH cancer
Abstract

Background and Aim Methods Results Conclusions The 2017 Japanese guidelines recommend continuing warfarin therapy during the perioperative period or discontinuing direct oral anticoagulants (DOACs) only on the day of endoscopic submucosal dissection for early gastric cancer. However, their safety has not been sufficiently explored. This study aimed to validate this management method.This retrospective, multicenter study analyzed the characteristics and outcomes of patients who underwent gastric endoscopic submucosal dissection between July 2017 and June 2019. The patients were categorized according to the use of warfarin or DOACs.Among the 62 eligible patients, 53 (85%) were male (median age, 76 years). Warfarin was used in 10 patients (16%) and DOACs in 52 patients (84%). Fourteen patients taking DOACs (27%) used concomitant antiplatelet agents, with seven patients (13%) continuing treatment at the time of the endoscopic procedure. No postprocedural bleeding occurred in patients receiving warfarin (0%), whereas 10 cases (19%) of bleeding occurred in patients receiving DOACs: rivaroxaban, 0% (0/22); dabigatran, 0% (0/2); edoxaban, 43% (6/14); and apixaban, 29% (4/14). The type of anticoagulant (P < 0.01) and continuation of antiplatelet therapy (P = 0.02) were risk factors for postprocedural bleeding in patients receiving DOACs. Intraprocedural bleeding requiring transfusion or symptomatic thromboembolic events were not reported.Continuous warfarin therapy is preferred. DOAC withdrawal 1 day before a procedure is associated with a high bleeding rate, which may differ for different types of anticoagulants. The continuation of antiplatelet medications in patients receiving DOACs carries a high risk of bleeding and is a future challenge. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

45. Pancreatic Exocrine Insufficiency in Intraductal Papillary Mucinous Carcinoma Presenting with Leg Edema Treated with Pancreatic Exocrine Replacement Therapy.

Author

Tanaka E, Ogawa T, Tsutsumi K, Kobayashi S, Nawa T, Ueki T, and Okada H

Subjects
Activities of Daily Living, Aged, 80 and over, Ascites, Edema etiology, Female, Humans, Leg pathology, Adenocarcinoma, Mucinous pathology, Adenocarcinoma, Papillary, Carcinoma, Pancreatic Ductal pathology, Exocrine Pancreatic Insufficiency, Pancreatic Neoplasms pathology, Pleural Effusion
Abstract

An 89-year-old woman underwent examinations for leg edema. Blood tests indicated low nutrition and low pancreatic enzymes, and a stool examination indicated fatty stool. Computed tomography showed pleural effusion, ascites, and cystic lesions in the pancreatic head and mural nodules within the cysts. Pancreatic juice cytology revealed adenocarcinoma. The diagnosis was pancreatic exocrine insufficiency caused by intraductal papillary mucinous carcinoma. The patient did not wish to undergo surgery. Therefore, diuretics, component nutrients, and pancreatic exocrine replacement therapy using pancrelipase were initiated. After starting treatment, her leg edema, pleural effusion, and ascites disappeared, and her activities of daily living improved markedly.

Published
2022
Full Text
View/download PDF

46. [Use of a somatostatin analog to improve a patient's condition and the subsequent diagnosis of pancreatic VIPoma:a case report].

Author

Kawahara S, Ueki T, Tsutsumi K, Oda T, Kobayashi S, Fujisawa T, Nawa T, Sadamori H, Ono K, and Omonishi K

Subjects
Aged, Female, Humans, Vasoactive Intestinal Peptide, Achlorhydria, Hormones therapeutic use, Pancreatic Neoplasms, Somatostatin therapeutic use, Vipoma
Abstract

A 68-year-old woman with an 11-day history of sudden abdominal pain and severe watery diarrhea was transferred to our hospital due to an exacerbation of renal function despite hydration. After treatment for dehydration and acidemia was provided in our intensive care unit, patient's renal function improved. Contrast-enhanced abdominal computed tomography was finally performed, revealing a hypervascular pancreatic mass with multiple hepatic masses. This imaging finding along with her clinical symptoms indicated watery diarrhea hypokalemia achlorhydria (WDHA) syndrome caused by a pancreatic VIPoma. Somatostatin analog was administered immediately leading to the improvement of her diarrhea and her general condition. As a result, endoscopic ultrasonography-guided fine-needle aspiration could be performed. Consequently, she was diagnosed with a pancreatic neuroendocrine tumor. She then underwent surgical resection of the pancreatic tumor and liver metastasis. As revealed in the immunohistochemical analysis of the excised tumor tissue, VIP was highly expressed, resulting in the final diagnosis of pancreatic VIPoma. Therefore, the immediate use of a somatostatin analog is crucial for improving the patient's general condition and achieving a definitive diagnosis pathologically when a patient is suspected of having a pancreatic VIPoma.

Published
2020
Full Text
View/download PDF

47. [A case of Hamman's syndrome associated with acute-onset type 1 diabetes mellitus presenting with abdominal pain].

Author

Hamamoto H, Sakaguchi K, Muro S, Sasaki K, Kobayashi S, Fujisawa T, Nawa T, Ueki T, Yabushita K, and Shimoe T

Subjects
Female, Humans, Pulmonary Fibrosis diagnostic imaging, Tomography, X-Ray Computed, Young Adult, Abdominal Pain etiology, Diabetes Mellitus, Type 1 complications, Pulmonary Fibrosis complications
Abstract

A 21-year-old female presented at an emergency department with abdominal pain and nausea. Computed tomography (CT) of the chest and abdomen revealed a small amount of mediastinal emphysema in the precardiac area, but the underlying cause could not be identified. On admission, her plasma glucose was 371 mg/dl, glycated hemoglobin (HbA1c) was 14.0%, and blood pH was 6.91. These findings supported a diagnosis of Hamman's syndrome associated with diabetic ketoacidosis. Her diabetic ketoacidosis was managed with insulin and fluid therapy, and the mediastinal emphysema disappeared spontaneously by the time of discharge. Presence of free air of the chest and abdominal cavity must warrant a differential diagnosis of gastrointestinal perforation; however, when the free air is accompanied by diabetic ketoacidosis, it is not necessary to perform urgent endoscopy.

Published
2015
Full Text
View/download PDF

48. [Classification of the bleeding pattern in colonic diverticulum is useful to predict the risk of bleeding or re-bleeding after endoscopic treatment].

Author

Kominami Y, Ohe H, Kobayashi S, Higashi R, Uchida D, Morimoto Y, Nakarai A, Numata N, Hirao K, Ogawa T, Ueki T, Nakagawa M, Araki Y, Mizuno M, and Chayama K

Subjects
Aged, Colonoscopy, Diverticulum, Colon pathology, Female, Humans, Male, Recurrence, Diverticulum, Colon complications, Gastrointestinal Hemorrhage pathology, Gastrointestinal Hemorrhage therapy
Abstract

We examined the re-bleeding rate after endoscopic hemostasis according to the bleeding pattern in patients with an acute lower gastrointestinal hemorrhage from colonic diverticula in 34 patients with active bleeding (Type 1) and 49 patients with exposed vessels and/or erosions in the base of diverticulum and no active bleeding (Type 2). Endoscopic hemostasis was performed by clipping the exposed vessel or erosions (direct method) or the entire diverticular orifice (reefing method). The incidence of re-bleeding was significantly higher in the Type 1 group than in the Type 2 group (p=0.002). All Type 1 cases were treated by the reefing method. In contrast, 14 of the 49 Type 2 cases were treated by the direct method, and no re-bleeding was observed in these cases. Of the other 35 Type 2 cases treated by reafing, rebleeding was seen in 5 cases. More effective endoscopic treatment is needed to prevent early re-bleeding, especially for Type 1 patients. The direct method may therefore reduce the rate of re-bleeding in Type 2 patients.

Published
2012

49. [Dynamic computed tomography is useful for the diagnosis and colonoscopic treatment of colonic diverticular bleeding].

Author

Kominami Y, Ohe H, Kobayashi S, Uchida D, Numata N, Matsushita H, Morimoto Y, Nakarai A, Nanba S, Ohta S, Ogawa T, Kurome M, Ueki T, Nakagawa M, Araki Y, and Mizuno M

Subjects
Aged, Diverticulum, Colon surgery, Extravasation of Diagnostic and Therapeutic Materials diagnostic imaging, Female, Gastrointestinal Hemorrhage surgery, Humans, Male, Colonoscopy, Diverticulum, Colon diagnostic imaging, Gastrointestinal Hemorrhage diagnostic imaging, Tomography, X-Ray Computed
Abstract

We investigated whether emergency dynamic computed tomography (CT) is helpful to identify bleeding colonic diverticulum treatable by colonoscopy. We enrolled 95 consecutive patients given diagnoses of colonic diverticular bleeding at Hiroshima City Hospital in the present study, of whom 60 underwent CT before colonoscopy (CT group), and 35 underwent colonoscopy alone (CS group). In the CT group, bleeding diverticula were identified and treated by colonoscopy in 31 of 32 (96.9%) patients in whom extravasation was detected by CT. The interval between bleeding being recognized and CT (median 1.0 hours) in patients in whom extravasation was detected by CT was shorter than that in whom extravasation was not detected (median 5.0 hours). To identify and treat bleeding diverticula by colonoscopy, the use of emergency dynamic CT prior to colonoscopy is recommended.

Published
2011

50. [Case of pseudoaneurysm ruptured into gallbladder and successfully treated with arterial embolization].

Author

Miyahara K, Ueki T, Mizuno M, Kobayashi S, Kajikawa N, Iwado S, Kurome M, Ohe H, Uematsu S, Okamoto R, Shiraga K, Nakagawa M, Nouso K, Araki Y, and Urashima M

Subjects
Aged, Aneurysm, Ruptured complications, Aneurysm, Ruptured diagnosis, Diagnostic Imaging, Gallbladder Diseases etiology, Hematemesis etiology, Hematoma etiology, Humans, Male, Treatment Outcome, Aneurysm, Ruptured therapy, Embolization, Therapeutic methods, Gallbladder blood supply
Abstract

A 79-year-old man was admitted with hematemesis. Emergency upper gastrointestinal tract endoscopy revealed bleeding from the papilla of Vater. Computed tomography showed cholecystitis with a gallstone and a hematoma in the gallbladder. Angiography demonstrated a pseudoaneurysm of the anterior branch of the right hepatic artery. Emergency selective transcatheter arterial embolization (TAE) was performed, with intravascular microcoils, and complete occlusion of the pseudoaneurysm was achieved. This case shows embolization is effective in the treatment of pseudoaneurysm rupturing in the gallbladder.

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results