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118 results on '"Knezevic, Vladimir"'

3. Quality of Life in Patients after Stroke.

Author

Jovanovic, Aleksandar, Dickov, Aleksandra, Knezevic, Vladimir, Pejin, Radoslav, and Nikovic, Jelena

Subjects
QUALITY of life, CEREBROVASCULAR disease, BRAIN diseases, MENTAL health, MENTAL depression
Abstract

The goal of all medical treatments is a better quality of life for patients. Post-stroke rehabilitation is a long process with uncertain result. The aim of this study was to explore the factors which affect the quality of life of patients recovering from a cerebrovascular disease. This is a prospective study evaluating the quality of life of one hundred patients one month and six months after a stroke, and patients also answered questions retrospectively, of how they felt before the stroke. As assessment tools we used a questionnaire on general and clinical data and Medical Outcomes Study Short Form (SF-36) questionnaire. Physical functioning and Physical role domains of SF-36 show significant differences in both measured periods (p<0.001). Emotional role, Social functioning, Mental health, Vitality and General health domains show a statistically significant change during first six months, while Bodily pain domain did not change (p>0.05). Physical summary score has changed significantly during 6 months (p <0.001). Mental summary score showed no significant difference in both periods (p <0.687; p <0.958). The brain localization is important factor (p<0.0002). Gender, age, education, employment status and previous strokes did not have a statistically significant influence (p> 0.05). Post-stroke physical impairment is not always accompanied by emotional impairment. Emotional functioning impairments generally return to the premorbid level during the period of six months, while physical impairments continue to occur. Further research is needed for better understanding of these relationships. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Rates of Vaccination against COVID-19 in Psychiatric Outpatients.

Author

Bosnjak, Mina Cvjetkovic, Kuljancic, Dusan, Vejnovic, Ana-Marija, Hinic, Darko, Knezevic, Vladimir, Ratkovic, Dragana, Bosic, Vanja, Vasic, Vesna, Sakic, Branislav, Segan, Darja, Savic, Predrag, Abazovic, Minja, Comic, Masa, Siladji, Djendji, Simic-Panic, Dusica, and Ivetic Poledica, Olga

Subjects
INFORMED consent (Medical law), MENTAL illness, PEOPLE with mental illness, COVID-19, COVID-19 vaccines
Abstract

Background: The aim of this study was to compare the rates of vaccination against COVID-19 infection in psychiatric outpatients and the general population, as well as rates of infected patients. In addition, the level and type of anxiety due to the pandemic were observed in patients with psychotic, anxiety, and depressive disorders. Materials and Methods: In the present study, 171 patients with pre-existing mental disorders completed the questionnaire about the doses and types of vaccination against COVID-19. During 2021–2023, patients with different mental disorders, aged from 18 to 80, were included. All patients filled in a self-reported questionnaire including general information (age, sex, marriage, education, working status, comorbid conditions) as well as questions about mental health, receiving vaccination, and the course of COVID-19 infection if it was present. All patients gave informed consent for the interview. Results: Patients with pre-existing mental disorders were more likely to be vaccinated against COVID-19 compared with the general population. The Sinopharm vaccine was most frequently applied. In the observed patients, 46.8% were infected, but just 7% had a medium or serious form of infection and were not vaccinated. Conclusions: In our study, the percentage of vaccinated psychiatric patients was greater than that in the general population, except in psychotic patients, who were mostly limited by fear. Such results can be explained by the high percentage of somatic comorbidities in this population and perhaps insufficient information about the positive effects of vaccination. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Methods of Microdissection and New Technologies

Author

Tangrea, Michael A., Gillespie, John W., Flaig, Michael J., Gannot, Gallya, Knezevic, Vladimir, Emmert-Buck, Michael R., Chuaqui, Rodrigo F., Emmert-Buck, Michael R., editor, Gillespie, John W., editor, and Chuaqui, Rodrigo F., editor

Published
2005
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19. The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid

Author

Knezevic, Vladimir, Ranson, Marie, and Mackem, Susan

Subjects
Homeobox genes -- Physiological aspects, Chick embryo -- Observations, Gastrulation -- Genetic aspects, Biological sciences
Abstract

The chick Gnot1 homeobox gene, a member of the Not gene family, is involved in the formation of the anteroposterior axis and gastrulation process. The epiblast expressing Gnot1 during blastulation is replaced by a localized region in the Hensen's node during gastrulation. The regressing primitive streak, tail bud and notochord express Gnot1 but the neural tube floorplate does not. The increase in expression of Gnot1 in the presence of both activin and retinoic acid is more than that if they are present alone. Cycloheximide also increases the expression of Gnot1.

Published
1995

20. Expression of TGF-beta-S and their receptors during implantation and organogenesis of the mouse embryo

Author

Roelen, Bernard A.J., Lin, Herbert Y., Knezevic, Vladimir, Freund, Eric, and Mummery, Christine L.

Subjects
Transforming growth factors -- Research, Embryology -- Research, Biological sciences
Abstract

In site hybridization, reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry help study the temporal and spatial expression of the types I, II and III receptors of transforming growth factor beta (TGF-beta) and their TGF-beta1 and TGF-beta2 ligands in mouse growth after implantation. RT-PCR reveals the lack of signaling type II and ALK-5 type I receptors in the germ layers and the differential expression of the type III and Tsk 7L type I receptors in 6.0 to 7.5 days postcoitum (dpc) embryos. TGF-beta type II receptor is expressed during late developmental stages in all differentiating tissues and organs except the brain and neural tube.

Published
1994

24. Quality of Life in Patients after Stroke

Author

Jovanovic, Aleksandar, Dickov, Aleksandra, Knezevic, Vladimir, Pejin, Radoslav, and Nikovic, Jelena

Abstract

The goal of all medical treatments is a better quality of life for patients. Post-stroke rehabilitation is a long process with uncertain result. The aim of this study was to explore the factors which affect the quality of life of patients recovering from a cerebrovascular disease. This is a prospective study evaluating the quality of life of one hundred patients one month and six months after a stroke, and patients also answered questions retrospectively, of how they felt before the stroke. As assessment tools we used a questionnaire on general and clinical data and Medical Outcomes Study Short Form (SF-36) questionnaire. Physical functioning and Physical role domains of SF-36 show significant differences in both measured periods (p<0.001). Emotional role, Social functioning, Mental health, Vitality and General health domains show a statistically significant change during first six months, while Bodily pain domain did not change (p>0.05). Physical summary score has changed significantly during 6 months (p <0.001). Mental summary score showed no significant difference in both periods (p <0.687; p <0.958). The brain localization is important factor (p<0.0002). Gender, age, education, employment status and previous strokes did not have a statistically significant influence (p> 0.05). Post-stroke physical impairment is not always accompanied by emotional impairment. Emotional functioning impairments generally return to the premorbid level during the period of six months, while physical impairments continue to occur. Further research is needed for better understanding of these relationships.

Published
2021
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25. A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay

Author

Kohn Elise, Knezevic Vladimir, Lorang Dominique, Baibakov Galina, Vu Huan, He Mei, O'Connor Sarah, Patton Angela, Kayton Mark L, Miller Walter J, Alexander H Richard, Stirling David, Payvandi Faribourz, Muller George W, and Libutti Steven K

Subjects
Angiogenesis, Chorioallantoic membrane (CAM), Confocal microscopy, XTT assay, Layered Expression Scanning (LES), Medicine
Abstract

Abstract Reliable quantitative evaluation of molecular pathways is critical for both drug discovery and treatment monitoring. We have modified the CAM assay to quantitatively measure vascular density, endothelial proliferation, and changes in protein expression in response to anti-angiogenic and pro-angiogenic agents. This improved CAM assay can correlate changes in vascular density with changes seen on a molecular level. We expect that these described modifications will result in a single in vivo assay system, which will improve the ability to investigate molecular mechanisms underlying the angiogenic response.

Published
2004
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29. Psychological medicine

Author

Knezevic, Vladimir, primary, Ratkovic, Dragana, additional, Knezevic, Jelena, additional, Ivanovic-Kovacevic, Svetlana, additional, Okanovic, Milana, additional, and Pavlovic, Sanja, additional

Published
2019
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35. Prevalence and Correlates of Aggression and Hostility in Hospitalized Schizophrenic Patients.

Author

Knezevic, Vladimir, Mitrovic, Dragan, Drezgic-Vukic, Svetlana, Knezevic, Jelena, Ivezic, Aleksandar, Siladji-Mladenovic, Djendji, and Golubovic, Boris

Subjects
*DIAGNOSIS of schizophrenia, *AGGRESSION (Psychology), *CLASSIFICATION of mental disorders, *RECIDIVISM, *SCHIZOPHRENIA, *SOCIOECONOMIC factors, *DISEASE prevalence, *DISEASE duration
Abstract

This study is aimed at identifying the incidence as well as clinical and socio-demographic correlates of aggression in hospitalized schizophrenic patients. We prospectively recruited participants with Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) diagnosis of schizophrenia presenting to the Clinic for Psychiatry during a 2-year period. We used the Modified Overt Aggression Scale to assess the aggression and Positive and Negative Syndrome Scale (PANSS) to assess the clinical characteristics of participants. One out of three patients with schizophrenia (31%) was aggressive and hostile at the time of presentation. Socio-demographic variables (such as gender, age, duration of illness, and number of hospitalizations) were poor predictors of aggression for schizophrenic patients. The level of aggression was not associated with the clinical characteristics in aggressive and hostile hospitalized schizophrenic patients. However, there was a weak negative association between the level of aggression and the PANSS Negative Scale (p < .01). In conclusion, socio-demographic variables and clinical characteristics seem to be not such good predictors of aggressive behavior in hospitalized schizophrenic patients. Nevertheless, the results of our study contribute to the understanding of the prediction and treatment of aggression in a well-defined cohort of schizophrenic patients. [ABSTRACT FROM AUTHOR]

Published
2017
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40. Layered Peptide Arrays

Author

Gannot, Gallya, primary, Tangrea, Michael A., additional, Gillespie, John W., additional, Erickson, Heidi S., additional, Wallis, Benjamin S., additional, Leakan, Rose Anne, additional, Knezevic, Vladimir, additional, Hartmann, Dan P., additional, Chuaqui, Rodrigo F., additional, and Emmert-Buck, Michael R., additional

Published
2005
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43. Modulation of Tumor-host Interactions, Angiogenesis, and Tumor Growth by Tissue Inhibitor of Metalloproteinase 2 via a Novel Mechanism

Author

Feldman, Andrew L., primary, Stetler-Stevenson, William G., additional, Costouros, Nick G., additional, Knezevic, Vladimir, additional, Baibakov, Galina, additional, Alexander, H. Richard, additional, Lorang, Dominique, additional, Hewitt, Stephen M., additional, Seo, Dong-Wan, additional, Miller, Marshall S., additional, O’Connor, Sarah, additional, and Libutti, Steven K., additional

Published
2004
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47. Layered expression scanning: multiplex analysis of RNA and protein gels

Author

Tangrea, Michael A., primary, Flaig, Michael J., additional, Ramesh, Arun, additional, Best, Carolyn J.M., additional, Baibakov, Galina V., additional, Hewitt, Stephen M., additional, Mitchell, Capre D., additional, Hartmann, Dan-Paul, additional, Knezevic, Vladimir, additional, Emmert-Buck, Michael R., additional, and Chuaqui, Rodrigo F., additional

Published
2003
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49. Post-analysis follow-up and validation of microarray experiments

Author

Chuaqui, Rodrigo F., primary, Bonner, Robert F., additional, Best, Carolyn J.M., additional, Gillespie, John W., additional, Flaig, Michael J., additional, Hewitt, Stephen M., additional, Phillips, John L., additional, Krizman, David B., additional, Tangrea, Michael A., additional, Ahram, Mamoun, additional, Linehan, W. Marston, additional, Knezevic, Vladimir, additional, and Emmert-Buck, Michael R., additional

Published
2002
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50. Proteomic profiling of the cancer microenvironment by antibody arrays

Author

Knezevic, Vladimir, primary, Leethanakul, Chidchanok, additional, Bichsel, Verena E., additional, Worth, Jennifer M., additional, Prabhu, Vinay V., additional, Gutkind, J. Silvio, additional, Liotta, Lance A., additional, Munson, Peter J., additional, Petricoin III, Emanuel F., additional, and Krizman, David B., additional

Published
2001
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