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354 results on '"Kasuga, Kensaku"'

1. CSF proteomics identifies early changes in autosomal dominant Alzheimer’s disease

Author

Noble, James M., Day, Gregory S., Graff-Radford, Neill R., Voglein, Jonathan, Allegri, Ricardo, Mendez, Patricio Chrem, Surace, Ezequiel, Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh, Lopera, Francisco, Ramirez, Laura, Aguillon, David, Leon, Yudy, Ramos, Claudia, Alzate, Diana, Baena, Ana, Londono, Natalia, Mathias Jucker, Sonia Moreno, Laske, Christoph, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Preische, Oliver, Hofmann, Anna, Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Ishii, Kenji, Senda, Michio, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Fox, Nick, Cash, Dave, Lee, Jae-Hong, Roh, Jee Hoon, Riddle, Meghan, Menard, William, Bodge, Courtney, Surti, Mustafa, Takada, Leonel Tadao, Farlow, Martin, Chhatwal, Jasmeer P., Sanchez-Gonzalez, V.J., Orozco-Barajas, Maribel, Goate, Alison, Renton, Alan, Esposito, Bianca, Karch, Celeste M., Marsh, Jacob, Cruchaga, Carlos, Fernandez, Victoria, Gordon, Brian A., Fagan, Anne M., Jerome, Gina, Herries, Elizabeth, Llibre-Guerra, Jorge, Levey, Allan I., Johnson, Erik C.B., Seyfried, Nicholas T., Schofield, Peter R., Brooks, William, Bechara, Jacob, Bateman, Randall J., McDade, Eric, Hassenstab, Jason, Perrin, Richard J., Franklin, Erin, Benzinger, Tammie L.S., Chen, Allison, Chen, Charles, Flores, Shaney, Friedrichsen, Nelly, Hantler, Nancy, Hornbeck, Russ, Jarman, Steve, Keefe, Sarah, Koudelis, Deborah, Massoumzadeh, Parinaz, McCullough, Austin, McKay, Nicole, Nicklaus, Joyce, Pulizos, Christine, Wang, Qing, Mishall, Sheetal, Sabaredzovic, Edita, Deng, Emily, Candela, Madison, Smith, Hunter, Hobbs, Diana, Scott, Jalen, Levin, Johannes, Xiong, Chengjie, Wang, Peter, Xu, Xiong, Li, Yan, Gremminger, Emily, Ma, Yinjiao, Bui, Ryan, Lu, Ruijin, Martins, Ralph, Sosa Ortiz, Ana Luisa, Daniels, Alisha, Courtney, Laura, Mori, Hiroshi, Supnet-Bell, Charlene, Xu, Jinbin, Ringman, John, Shen, Yuanyuan, Timsina, Jigyasha, Heo, Gyujin, Beric, Aleksandra, Ali, Muhammad, Wang, Ciyang, Yang, Chengran, Wang, Yueyao, Western, Daniel, Liu, Menghan, Gorijala, Priyanka, Budde, John, Do, Anh, Liu, Haiyan, Gordon, Brian, Llibre-Guerra, Jorge J., Joseph-Mathurin, Nelly, Maschi, Dario, Wyss-Coray, Tony, Pastor, Pau, Renton, Alan E., Surace, Ezequiel I., Alvarez, Ignacio, Ringman, John M., Allegri, Ricardo Francisco, Seyfried, Nicholas, Day, Gregg S., Wu, Qisi, Fernández, M. Victoria, Tarawneh, Rawan, Morris, John C., Ibanez, Laura, and Sung, Yun Ju

Published
2024
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2. γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)

Author

Aguillon, David, Allegri, Ricardo F., Aschenbrenner, Andrew J., Baker, Bryce, Barthelemy, Nicolas, Bechara, Jacob A., Berman, Sarah B., Brooks, William S., Cash, David M., Chen, Allison, Chrem Mendez, Patricio, Courtney, Laura, Cruchaga, Carlos, Daniels, Alisha J., Fagan, Anne M., Flores, Shaney, Fox, Nick C., Franklin, Erin, Goate, Alison M., Graber-Sultan, Susanne, Graff-Radford, Neill R., Gremminger, Emily, Herries, Elizabeth, Hofmann, Anna, Holtzman, David M., Hornbeck, Russ, Huey, Edward D., Ibanez, Laura, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jackson, Kelley, Jarman, Steve, Jerome, Gina, Johnson, Erik C.B, Kasuga, Kensaku, Keefe, Sarah, Koudelis, Deborah, Kuder-Buletta, Elke, Laske, Christoph, Leon, Yudy Milena, Levey, Allan I., Li, Yan, Llibre-Guerra, Jorge J., Lopera, Francisco, Lu, Ruijin, Marsh, Jacob, Martins, Ralph, Massoumzadeh, Parinaz, Masters, Colin, McCullough, Austin, McKay, Nicole, Minton, Matthew, Mori, Hiroshi, Morris, John C., Nadkarni, Neelesh K., Nicklaus, Joyce, Niimi, Yoshiki, Noble, James M., Obermueller, Ulrike, Picarello, Danielle M., Pulizos, Christine, Ramirez, Laura, Renton, Alan E., Ringman, John, Rizzo, Jacqueline, Roedenbeck, Yvonne, Roh, Jee Hoon, Rosa-Neto, Pedro, Ryan, Natalie S., Sabaredzovic, Edita, Salloway, Stephen, Sanchez-Valle, Raquel, Scott, Jalen, Seyfried, Nicholas T., Simmons, Ashlee, Smith, Jennifer, Smith, Hunter, Stauber, Jennifer, Stout, Sarah, Supnet-Bell, Charlene, Surace, Ezequiel, Vazquez, Silvia, Vöglein, Jonathan, Wang, Guoqiao, Wang, Qing, Xu, Xiong, Xu, Jinbin, Schultz, Stephanie A, Liu, Lei, Schultz, Aaron P, Fitzpatrick, Colleen D, Levin, Raina, Bellier, Jean-Pierre, Shirzadi, Zahra, Joseph-Mathurin, Nelly, Chen, Charles D, Benzinger, Tammie L S, Day, Gregory S, Farlow, Martin R, Gordon, Brian A, Hassenstab, Jason J, Jack, Clifford R, Jr, Jucker, Mathias, Karch, Celeste M, Lee, Jae-Hong, Levin, Johannes, Perrin, Richard J, Schofield, Peter R, Xiong, Chengjie, Johnson, Keith A, McDade, Eric, Bateman, Randall J, Sperling, Reisa A, Selkoe, Dennis J, and Chhatwal, Jasmeer P

Published
2024
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4. Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

Author

Kommaddi, Reddy Peera, Verma, Aditi, Muniz-Terrera, Graciela, Tiwari, Vivek, Chithanathan, Keerthana, Diwakar, Latha, Gowaikar, Ruturaj, Karunakaran, Smitha, Malo, Palash Kumar, Graff-Radford, Neill R., Day, Gregory S., Laske, Christoph, Vöglein, Jonathan, Nübling, Georg, Ikeuchi, Takeshi, Kasuga, Kensaku, and Ravindranath, Vijayalakshmi

Published
2023
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5. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

Author

Aizenstein, Howard J., Andrews, Howard F., Bell, Karen, Birn, Rasmus M., Bulova, Peter, Cheema, Amrita, Chen, Kewei, Clare, Isabel, Clark, Lorraine, Cohen, Ann D., Constantino, John N., Doran, Eric W., Feingold, Eleanor, Foroud, Tatiana M., Hartley, Sigan L., Hom, Christy, Honig, Lawrence, Ikonomovic, Milos D., Johnson, Sterling C., Jordan, Courtney, Kamboh, M. Ilyas, Keator, David, Klunk, William E., Kofler, Julia K., Kreisl, William C., Krinsky-McHale, Sharon J., Lao, Patrick, Laymon, Charles, Lott, Ira T., Lupson, Victoria, Mathis, Chester A., Minhas, Davneet S., Nadkarni, Neelesh, Pang, Deborah, Petersen, Melissa, Price, Julie C., Pulsifer, Margaret, Reiman, Eric, Rizvi, Batool, Sabbagh, Marwan N., Schupf, Nicole, Tudorascu, Dana L., Tumuluru, Rameshwari, Tycko, Benjamin, Varadarajan, Badri, White, Desiree A., Yassa, Michael A., Zaman, Shahid, Zhang, Fan, Bateman, Randall, Daniels, Alisha J., Courtney, Laura, McDade, Eric, Llibre-Guerra, Jorge J., Supnet-Bell, Charlene, Xiong, Chengie, Xu, Xiong, Lu, Ruijin, Wang, Guoqiao, Li, Yan, Gremminger, Emily, Perrin, Richard J., Franklin, Erin, Ibanez, Laura, Jerome, Gina, Herries, Elizabeth, Stauber, Jennifer, Baker, Bryce, Minton, Matthew, Cruchaga, Carlos, Goate, Alison M., Renton, Alan E., Picarello, Danielle M., Benzinger, Tammie, Gordon, Brian A., Hornbeck, Russall, Hassenstab, Jason, Smith, Jennifer, Stout, Sarah, Aschenbrenner, Andrew J., Karch, Celeste M., Marsh, Jacob, Morris, John C., Holtzman, David M., Barthelemy, Nicolas, Xu, Jinbin, Noble, James M., Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh K., Day, Gregory, Graff-Radford, Neill R., Farlow, Martin, Chhatwal, Jasmeer P., Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Huey, Edward D., Salloway, Stephen, Schofield, Peter R., Brooks, William S., Bechara, Jacob A., Martins, Ralph, Fox, Nick C., Cash, David M., Ryan, Natalie S., Jucker, Mathias, Laske, Christoph, Hofmann, Anna, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Obermueller, Ulrike, Levin, Johannes, Roedenbeck, Yvonne, Vöglein, Jonathan, Lee, Jae-Hong, Roh, Jee Hoon, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Allegri, Ricardo F., Chrem Mendez, Patricio, Surace, Ezequiel, Vazquez, Silvia, Lopera, Francisco, Leon, Yudy Milena, Ramirez, Laura, Aguillon, David, Levey, Allan I., Johnson, Erik C.B, Seyfried, Nicholas T., Ringman, John, Mori, Hiroshi, Wisch, Julie K, McKay, Nicole S, Boerwinkle, Anna H, Kennedy, James, Flores, Shaney, Handen, Benjamin L, Christian, Bradley T, Head, Elizabeth, Mapstone, Mark, Rafii, Michael S, O’Bryant, Sid E, Price, Julie C, Laymon, Charles M, Krinsky-McHale, Sharon J, Lai, Florence, Rosas, H Diana, Hartley, Sigan L, Lott, Ira T, Tudorascu, Dana, Zammit, Matthew, Brickman, Adam M, Lee, Joseph H, Bird, Thomas D, Cohen, Annie, Chrem, Patricio, Daniels, Alisha, Chhatwal, Jasmeer P, Karch, Celeste M, Day, Gregory S, Llibre-Guerra, Jorge, Ringman, John M, van Dyck, Christopher H, Xiong, Chengjie, Morris, John C, Bateman, Randall J, Benzinger, Tammie L S, Gordon, Brian A, and Ances, Beau M

Published
2024
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6. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

Author

Noble, James M., Day, Gregory S., Graff-Radford, Neill R., Voglein, Jonathan, Levin, Johannes, Allegri, Ricardo F., Mendez, Patricio Chrem, Surace, Ezequiel, Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh K., Lopera, Francisco, Ramirez, Laura, Aguillon, David, Leon, Yudy, Ramos, Claudia, Alzate, Diana, Baena, Ana, Londono, Natalia, Moreno, Sonia, Jucker, Mathias, Laske, Christoph, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Preische, Oliver, Hofmann, Anna, Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Ishii, Kenji, Senda, Michio, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Fox, Nick C., Cash, Dave, Lee, Jae-Hong, Roh, Jee Hoon, Salloway, Stephen, Riddle, Meghan C., Menard, William, Bodge, Courtney, Surti, Mustafa, Takada, Leonel Tadao, Farlow, Martin, Chhatwal, Jasmeer P., Sanchez-Gonzalez, V.J., Orozco-Barajas, Maribel, Goate, Alison M., Renton, Alan E., Esposito, Bianca T., Karch, Celeste M., Marsh, Jacob, Cruchaga, Carlos, Fernanadez, Victoria, Gordon, Brian A., Fagan, Anne M., Jerome, Gina, Herries, Elizabeth, Llibre-Guerra, Jorge, Levey, Allan I., Johnson, Erik C.B., Seyfried, Nicholas T., Schofield, Peter R., Brooks, William S., Bechara, Jacob A., Bateman, Randall, McDade, Eric, Hassenstab, Jason, Perrin, Richard J., Franklin, Erin E., Benzinger, Tammie, Chen, Allison, Chen, Charles, Flores, Shaney, Friedrichsen, Nelly, Gordon, Brian, Hantler, Nancy, Hornbeck, Russ, Jarman, Steve, Keefe, Sarah, Koudelis, Deborah, Massoumzadeh, Parinaz, McCullough, Austin, McKay, Nicole, Nicklaus, Joyce, Pulizos, Christine, Wang, Qing, Mishall, Sheetal, Sabaredzovic, Edita, Deng, Emily, Candela, Madison, Smith, Hunter, Hobbs, Diana, Scott, Jalen, Xiong, Chengjie, Wang, Peter, Xu, Xiong, Li, Yan, Gremminger, Emily, Ma, Yinjiao, Bui, Ryan, Lu, Ruijin, Martins, Ralph, Sosa Ortiz, Ana Luisa, Daniels, Alisha, Courtney, Laura, Mori, Hiroshi, Supnet-Bell, Charlene, Xu, Jinbin, Ringman, John, Barthelemy, Nicolas, Morris, John, Smith, Jennifer, Doering, Stephanie, Chen, Charles D., Jarman, Stephen, Jackson, Kelley, Hornbeck, Russ C., Ances, Beau M., Aschenbrenner, Andrew J., Bateman, Randall J., Morris, John C., and Benzinger, Tammie L.S.

Published
2024
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7. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Author

Abdi, Zeinab, Agosta, Federica, Ahmed, Samrah, Alcolea, Daniel, Allen, Isabel Elaine, Allinson, Kieren S.J., Apostolova, Liana G., Arighi, Andrea, Balasa, Mircea, Barkhof, Frederik, Best, John, Boon, Baayla D., Brandt, Katherine D., Brosch, Jared, Burrell, James, Butler, Christopher R., Calandri, Ismael, Caminiti, Silvia Paola, Canu, Elisa, Carrillo, Maria C., Caso, Francesca, Chapleau, Marianne, Chrem Mendez, Patricio, Chu, Min, Crutch, Sebastian, Cordato, Nicholas, Costa, Ana Sofia, Cui, Yue, Dickerson, Bradford, Dickson, Dennis W., Duara, Ranjan, Dubois, Bruno, Eldaief, Mark, Farlow, Martin, Fenoglio, Chiara, Filippi, Massimo, Fliessbach, Klaus, Formaglio, Maïté, Fortea, Juan, Fox, Nick, Foxe, David, Tilikete, Caroline Froment, Frosch, Matthew P., Fumagalli, Giorgio Giulio, Galasko, Douglas, Galimberti, Daniela, Garat, Oscar, Giardinieri, Giulia, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grinberg, Lea, Groot, Colin, Hake, Ann Marie, Hansson, Oskar, Headley, Alison, Hernandez, Micaela, Hochberg, Daisy, Hodges, John R., Hof, Patrick R., Holton, Janice, Hromas, Gabrielle, Gala, Ignacio Illán, Irwin, David J., Jaunmuktane, Zane, Jing, Donglai, Josephs, Keith, Kagerer, Sonja M., Kasuga, Kensaku, Kong, Yu, Kövari, Enikö, Lacombe-Thibault, Mégane, Lleó, Alberto, Laforce, Robert, La Joie, Renaud, Lashley, Tammaryn, Leger, Gabriel, Levin, Netta, Levy, Richard, Liu, Yang, Liu, Li, Lladó Plarrumaní, Albert, Lucente, Diane E., Machulda, Mary M., Magnani, Giuseppe, Magnin, Eloi, Malpetti, Maura, Matthews, Brandy, McGinnis, Scott, Mendez, Mario F., Mesulam, Marsel, Migliaccio, Raffaella, Miklitz, Carolin, Miller, Zachary A., Montembeault, Maxime, Murray, Melissa E., Mundada, Nidhi, Nemes, Sara, Nestor, Peter J., Ocal, Dilek, Ossenkoppele, Rik, Paterson, Ross, Pelak, Victoria, Perani, Daniela, Phillips, Jeffrey, Piguet, Olivier, Pijnenburg, Yolande, Putcha, Deepti, Quimby, Megan, Rabinovici, Gil D., Reetz, Kathrin, Rein, Netaniel, Revesz, Tamas, Rezaii, Neguine, Rodriguez-Porcel, Federico, Rogalski, Emily, Rowe, James B., Ryan, Natalie, Sanchez-Valle, Raquel, Sacchi, Luca, Santos-Santos, Miguel Ángel, Schott, Jonathan M., Seeley, William, Sherman, Janet, Spina, Salvatore, Stomrud, Erik, Sullivan, A. Campbell, Tanner, Jeremy, Tideman, Pontus, Tokutake, Takayoshi, Tondo, Giacomo, Touroutoglou, Alexandra, Tousi, Babak, Vandenberghe, Rik, van der Flier, Wiesje, Walker, Jamie M., Weintraub, Sandra, Whitwell, Jennifer L., Wolk, David A., Wong, Bonnie, Wu, Liyong, Xie, Kexin, Yong, Keir, Apostolova, Liana, Boon, Baayla D C, Grinberg, Lea T, Irwin, David J, Josephs, Keith A, Mendez, Mario F, Mendez, Patricio Chrem, Miller, Zachary A, Murray, Melissa E, Nemes, Sára, Schott, Jonathan M, Sullivan, A Campbell, Walker, Jamie, Whitwell, Jennifer L, Wolk, David A, and Rabinovici, Gil D

Published
2024
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11. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Author

Aizenstein, Howard J, Andrews, Howard F, Bell, Karen, Birn, Rasmus M, Bulova, Peter, Cheema, Amrita, Chen, Kewei, Clare, Isabel, Clark, Lorraine, Cohen, Ann D, Constantino, John N, Doran, Eric W, Feingold, Eleanor, Foroud, Tatiana M, Hartley, Sigan L, Hom, Christy, Honig, Lawrence, Ikonomovic, Milos D, Johnson, Sterling C, Jordan, Courtney, Kamboh, M Ilyas, Keator, David, Klunk MD, William E, Kofler, Julia K, Kreisl, William C, Krinsky- McHale, Sharon J, Lao, Patrick, Laymon, Charles, Lott, Ira T, Lupson, Victoria, Mathis, Chester A, Minhas, Davneet S, Nadkarni, Neelesh, Pang, Deborah, Petersen, Melissa, Price, Julie C, Pulsifer, Margaret, Reiman, Eric, Rizvi, Batool, Sabbagh, Marwan N, Schupf, Nicole, Tudorascu, Dana L, Tumuluru, Rameshwari, Tycko, Benjamin, Varadarajan, Badri, White, Desiree A, Yassa, Michael A, Zaman, Shahid, Zhang, Fan, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Mendez, Patricio C, Chua, Jasmin, Chui, Helena, Courtney, Laura, Day, Gregory, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häslerc, Lisa, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal S, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John C, Mountz, James, Mummery, Catherine, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Boerwinkle, Anna H, Gordon, Brian A, Wisch, Julie, Flores, Shaney, Henson, Rachel L, Butt, Omar H, McKay, Nicole, Chen, Charles D, Benzinger, Tammie L S, Fagan, Anne M, Handen, Benjamin L, Christian, Bradley T, Head, Elizabeth, Mapstone, Mark, Rafii, Michael S, O'Bryant, Sid, Lai, Florence, Rosas, H Diana, Lee, Joseph H, Silverman, Wayne, Brickman, Adam M, Chhatwal, Jasmeer P, Cruchaga, Carlos, Perrin, Richard J, Xiong, Chengjie, Hassenstab, Jason, McDade, Eric, Bateman, Randall J, and Ances, Beau M

Published
2023
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12. Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide

Author

Hata, Saori, Saito, Haruka, Kakiuchi, Takeharu, Fukumoto, Dai, Yamamoto, Shigeyuki, Kasuga, Kensaku, Kimura, Ayano, Moteki, Koichi, Abe, Ruriko, Adachi, Shungo, Kinoshita, Shoich, Yoshizawa‐Kumagaye, Kumiko, Nishio, Hideki, Saito, Takashi, Saido, Takaomi C, Yamamoto, Tohru, Nishimura, Masaki, Taru, Hidenori, Sobu, Yuriko, Ohba, Hiroyuki, Nishiyama, Shingo, Harada, Norihiro, Ikeuchi, Takeshi, Tsukada, Hideo, Ouchi, Yasuomi, and Suzuki, Toshiharu

Published
2023
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14. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease

Author

Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Mendez, Patricio Chrem, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häsler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, N eelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Millar, Peter R., Luckett, Patrick H., Gordon, Brian A., Benzinger, Tammie L.S., Schindler, Suzanne E., Fagan, Anne M., Bateman, Randall J., Lee, Jae-Hong, Mori, Hiroshi, Salloway, Stephen P, Yakushev, Igor, Morris, John C., and Ances, Beau M.

Published
2022
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15. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

Author

Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem, Patricio, Chua, Jasmin, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Häsler, Lisa, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William (Bill), Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Lopez, Oscar, Marsh, Jacob, Martinez, Rita, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, Mejia, Arlene, MountzMD, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nick, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Morenas-Rodríguez, Estrella, Li, Yan, Franzmeier, Nicolai, Xiong, Chengjie, Suárez-Calvet, Marc, Fagan, Anne M, Schultz, Stephanie, Gordon, Brian A, Benzinger, Tammie L S, Hassenstab, Jason, McDade, Eric, Feederle, Regina, Karch, Celeste M, Schlepckow, Kai, Morris, John C, Kleinberger, Gernot, Nellgard, Bengt, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Levin, Johannes, Bateman, Randall J, and Haass, Christian

Published
2022
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16. Public perceptions related to healthcare preparedness to anti-amyloid therapies for Alzheimer's Disease in Japan.

Author

Sato, Kenichiro, Niimi, Yoshiki, Ihara, Ryoko, Iwata, Atsushi, Suzuki, Kazushi, Nemoto, Kiyotaka, Arai, Tetsuaki, Higashi, Shinji, Igarashi, Ataru, Kasuga, Kensaku, Awata, Shuichi, and Iwatsubo, Takeshi

Subjects
ALZHEIMER'S disease, PUBLIC opinion, MEDICAL personnel, SIMILARITY (Psychology), PATIENTS' attitudes
Abstract

Background: The approval of lecanemab, an anti-amyloid therapy for Alzheimer's disease (AD), necessitates addressing healthcare preparedness for disease-modifying treatment (DMT) to ensure appropriate, safe, and sustainable drug administration. Understanding public perceptions on this matter is crucial. We aimed to assess discrepancies and similarities in the perceptions of Japanese trial-ready cohort study ('J-TRC webstudy') participants and clinical specialists in the fields of dementia treatment and radiology, concerning affairs related to challenges in DMT preparedness. Methods: This was a cross-sectional prospective observational study conducted in November–December 2023. The J-TRC webstudy participants were invited to participate in an online survey using Google Forms, and clinical specialists were invited to complete a mail-based survey. Main questionnaire items had been designed to be common in both surveys, and their responses were analyzed for participant attributes, interests, attitudes, expectations, and concerns about DMTs without specifying lecanemab. Results: Responses were obtained from n = 2,050 J-TRC webstudy participants and n = 1,518 clinical specialists. Compared to specialists, more J-TRC respondents perceived the eligible proportion for DMT as smaller (59.1% versus 30.7%), perceived the eligible severity for DMT as more limited (58.0% versus 24.5%), and perceived the efficacy of DMT as slightly more encouraging (29.3% versus 34.8%). In terms of treatment prioritization, both J-TRC respondents and specialist respondents exhibited similar levels of acceptance for prioritizing patients to treat: e.g., approximately two-thirds endorsed patient prioritization under hypothetical resource constraints or other reasons. A medical rationale emerged as the most compelling reason for acceptance of patient prioritization across the surveys. In contrast, the need to address vulnerable populations was the reason that led to the least acceptance of prioritization, followed by economic considerations. Conclusions: Our findings offer valuable insights into the discrepancies in knowledge and perception between patients and healthcare providers. This could enhance the delivery of patient information in clinical settings and inform the discussion surrounding patient prioritization strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Alzheimer's Disease-Related Cerebrospinal Fluid Biomarkers in Progressive Supranuclear Palsy.

Author

Ishiguro, Takanobu and Kasuga, Kensaku

Subjects
*ALZHEIMER'S disease, *TAU proteins, *TAUOPATHIES, *CEREBROSPINAL fluid, *NEURODEGENERATION
Abstract

Highlights: Progressive Supranuclear Palsy (PSP) presents with various clinical phenotypes, making accurate diagnosis difficult. No biomarker systems, such as the AT(N) system for Alzheimer's Disease (AD), have been established yet. In PSP, core AD cerebrospinal fluid biomarkers show a unique pattern, where Aβ42, Aβ40, p-tau, and t-tau levels are decreased while NfL levels are remarkably increased. Progressive Supranuclear Palsy (PSP) is the most common four-repeat tauopathy. PSP cases are typically characterized by vertical gaze palsy and postural instability; however, various phenotypes have been reported, making antemortem diagnosis based on clinical symptoms challenging. The development of biomarkers reflecting brain pathology and the ability to diagnose patients based on these biomarkers are essential for developing future intervention strategies, including disease-modifying therapies. However, despite many dedicated efforts, no highly specific fluid biomarker for PSP has yet been established. Conversely, several cerebrospinal fluid (CSF) biomarkers of Alzheimer's Disease (AD) have been established, and an AT(N) classification system has been proposed. Typically, among patients with AD, CSF amyloid β42 (Aβ42), but not Aβ40, is decreased, resulting in a reduction in the Aβ42/Aβ40 ratio, while tau phosphorylated at threonine 181 (p-tau181) and total tau (t-tau) are increased. Interestingly, the core CSF AD biomarkers show unique patterns in patients with PSP. Furthermore, reports have indicated that the CSF levels of both Aβ42 and Aβ40 are decreased independently of Aβ accumulation in PSP. Therefore, the Aβ42/Aβ40 ratio could potentially be used to differentiate PSP from AD. Additionally, studies have reported that CSF p-tau and t-tau are reduced in PSP, and that the neurofilament light chain is remarkably increased compared to healthy controls and patients with AD, even though PSP is a neurodegenerative disease associated with tau accumulation. These PSP-specific changes in AD-related core biomarkers may reflect the pathology of PSP and contribute to its diagnosis. As such, elucidating the mechanisms underlying the observed decreases in Aβ and tau levels could facilitate a better understanding of the pathogenesis of PSP. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly

Author

Niimi, Yoshiki, primary, Janelidze, Shorena, additional, Sato, Kenichiro, additional, Tomita, Naoki, additional, Tsukamoto, Tadashi, additional, Kato, Takashi, additional, Yoshiyama, Kenji, additional, Kowa, Hisatomo, additional, Iwata, Atsushi, additional, Ihara, Ryoko, additional, Suzuki, Kazushi, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, Ishii, Kenji, additional, Ito, Kengo, additional, Nakamura, Akinori, additional, Senda, Michio, additional, Day, Theresa A., additional, Burnham, Samantha C., additional, Iaccarino, Leonardo, additional, Pontecorvo, Michael J., additional, Hansson, Oskar, additional, and Iwatsubo, Takeshi, additional

Published
2024
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20. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

Author

Doering, Stephanie, primary, McCullough, Austin, additional, Gordon, Brian A., additional, Chen, Charles D., additional, McKay, Nicole, additional, Hobbs, Diana, additional, Keefe, Sarah, additional, Flores, Shaney, additional, Scott, Jalen, additional, Smith, Hunter, additional, Jarman, Stephen, additional, Jackson, Kelley, additional, Hornbeck, Russ C., additional, Ances, Beau M., additional, Xiong, Chengjie, additional, Aschenbrenner, Andrew J., additional, Hassenstab, Jason, additional, Cruchaga, Carlos, additional, Daniels, Alisha, additional, Bateman, Randall J., additional, Noble, James M., additional, Day, Gregory S., additional, Graff-Radford, Neill R., additional, Voglein, Jonathan, additional, Levin, Johannes, additional, Allegri, Ricardo F., additional, Mendez, Patricio Chrem, additional, Surace, Ezequiel, additional, Berman, Sarah B., additional, Ikonomovic, Snezana, additional, Nadkarni, Neelesh K., additional, Lopera, Francisco, additional, Ramirez, Laura, additional, Aguillon, David, additional, Leon, Yudy, additional, Ramos, Claudia, additional, Alzate, Diana, additional, Baena, Ana, additional, Londono, Natalia, additional, Moreno, Sonia, additional, Jucker, Mathias, additional, Laske, Christoph, additional, Kuder-Buletta, Elke, additional, Graber-Sultan, Susanne, additional, Preische, Oliver, additional, Hofmann, Anna, additional, Ikeuchi, Takeshi, additional, Kasuga, Kensaku, additional, Niimi, Yoshiki, additional, Ishii, Kenji, additional, Senda, Michio, additional, Sanchez-Valle, Raquel, additional, Rosa-Neto, Pedro, additional, Fox, Nick C., additional, Cash, Dave, additional, Lee, Jae-Hong, additional, Roh, Jee Hoon, additional, Salloway, Stephen, additional, Riddle, Meghan C., additional, Menard, William, additional, Bodge, Courtney, additional, Surti, Mustafa, additional, Takada, Leonel Tadao, additional, Farlow, Martin, additional, Chhatwal, Jasmeer P., additional, Sanchez-Gonzalez, V.J., additional, Orozco-Barajas, Maribel, additional, Goate, Alison M., additional, Renton, Alan E., additional, Esposito, Bianca T., additional, Karch, Celeste M., additional, Marsh, Jacob, additional, Fernanadez, Victoria, additional, Fagan, Anne M., additional, Jerome, Gina, additional, Herries, Elizabeth, additional, Llibre-Guerra, Jorge, additional, Levey, Allan I., additional, Johnson, Erik C.B., additional, Seyfried, Nicholas T., additional, Schofield, Peter R., additional, Brooks, William S., additional, Bechara, Jacob A., additional, Bateman, Randall, additional, McDade, Eric, additional, Perrin, Richard J., additional, Franklin, Erin E., additional, Benzinger, Tammie, additional, Chen, Allison, additional, Chen, Charles, additional, Friedrichsen, Nelly, additional, Gordon, Brian, additional, Hantler, Nancy, additional, Hornbeck, Russ, additional, Jarman, Steve, additional, Koudelis, Deborah, additional, Massoumzadeh, Parinaz, additional, Nicklaus, Joyce, additional, Pulizos, Christine, additional, Wang, Qing, additional, Mishall, Sheetal, additional, Sabaredzovic, Edita, additional, Deng, Emily, additional, Candela, Madison, additional, Wang, Peter, additional, Xu, Xiong, additional, Li, Yan, additional, Gremminger, Emily, additional, Ma, Yinjiao, additional, Bui, Ryan, additional, Lu, Ruijin, additional, Martins, Ralph, additional, Sosa Ortiz, Ana Luisa, additional, Courtney, Laura, additional, Mori, Hiroshi, additional, Supnet-Bell, Charlene, additional, Xu, Jinbin, additional, Ringman, John, additional, Barthelemy, Nicolas, additional, Morris, John, additional, Smith, Jennifer, additional, Morris, John C., additional, and Benzinger, Tammie L.S., additional

Published
2024
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23. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Author

Chapleau, Marianne, primary, La Joie, Renaud, additional, Yong, Keir, additional, Agosta, Federica, additional, Allen, Isabel Elaine, additional, Apostolova, Liana, additional, Best, John, additional, Boon, Baayla D C, additional, Crutch, Sebastian, additional, Filippi, Massimo, additional, Fumagalli, Giorgio Giulio, additional, Galimberti, Daniela, additional, Graff-Radford, Jonathan, additional, Grinberg, Lea T, additional, Irwin, David J, additional, Josephs, Keith A, additional, Mendez, Mario F, additional, Mendez, Patricio Chrem, additional, Migliaccio, Raffaella, additional, Miller, Zachary A, additional, Montembeault, Maxime, additional, Murray, Melissa E, additional, Nemes, Sára, additional, Pelak, Victoria, additional, Perani, Daniela, additional, Phillips, Jeffrey, additional, Pijnenburg, Yolande, additional, Rogalski, Emily, additional, Schott, Jonathan M, additional, Seeley, William, additional, Sullivan, A Campbell, additional, Spina, Salvatore, additional, Tanner, Jeremy, additional, Walker, Jamie, additional, Whitwell, Jennifer L, additional, Wolk, David A, additional, Ossenkoppele, Rik, additional, Rabinovici, Gil D, additional, Abdi, Zeinab, additional, Ahmed, Samrah, additional, Alcolea, Daniel, additional, Allinson, Kieren S.J., additional, Arighi, Andrea, additional, Balasa, Mircea, additional, Barkhof, Frederik, additional, Brandt, Katherine D., additional, Brosch, Jared, additional, Burrell, James, additional, Butler, Christopher R., additional, Calandri, Ismael, additional, Caminiti, Silvia Paola, additional, Canu, Elisa, additional, Carrillo, Maria C., additional, Caso, Francesca, additional, Chu, Min, additional, Cordato, Nicholas, additional, Costa, Ana Sofia, additional, Cui, Yue, additional, Dickerson, Bradford, additional, Dickson, Dennis W., additional, Duara, Ranjan, additional, Dubois, Bruno, additional, Eldaief, Mark, additional, Farlow, Martin, additional, Feneglio, Chiara, additional, Fliessbach, Klaus, additional, Formaglio, Maïté, additional, Fortea, Juan, additional, Fox, Nick, additional, Foxe, David, additional, Tilikete, Caroline Froment, additional, Frosch, Matthew P., additional, Galasko, Douglas, additional, Garat, Oscar, additional, Giardinieri, Giulia, additional, Graff-Radford, Neill R., additional, Groot, Colin, additional, Hake, Ann Marie, additional, Hansson, Oskar, additional, Headley, Alison, additional, Hernandez, Micaela, additional, Hochberg, Daisy, additional, Hodges, John R., additional, Hof, Patrick R., additional, Holton, Janice, additional, Hromas, Gabrielle, additional, Illán Gala, Ignacio, additional, Jaunmuktane, Zane, additional, Jing, Donglai, additional, Kagerer, Sonja M., additional, Kasuga, Kensaku, additional, Kong, Yu, additional, Kövari, Enikö, additional, Lacombe-Thibault, Mégane, additional, Lleó Plarrumaní, Alberto, additional, Lucente, Diane E., additional, Machulda, Mary M., additional, Magnani, Giuseppe, additional, Magnin, Eloi, additional, Malpetti, Maura, additional, Matthews, Brandy, additional, McGinnis, Scott, additional, Mesulam, Marsel, additional, Miklitz, Carolin, additional, Mundada, Nidhi, additional, Nestor, Peter J., additional, Ocal, Dilek, additional, Paterson, Ross, additional, Piguet, Olivier, additional, Putcha, Deepti, additional, Quimby, Megan, additional, Reetz, Kathrin, additional, Rein, Netaniel, additional, Revesz, Tamas, additional, Rezaii, Neguine, additional, Rodriguez-Porcel, Federico, additional, Rowe, James B., additional, Ryan, Natalie, additional, Sanchez-Valle, Raquel, additional, Sacchi, Luca, additional, Santos-Santos, Miguel Ángel, additional, Sherman, Janet, additional, Stomrud, Erik, additional, Tideman, Pontus, additional, Tokutake, Takayoshi, additional, Tondo, Giacomo, additional, Touroutoglou, Alexandra, additional, Tousi, Babak, additional, Vandenberghe, Rik, additional, van der Flier, Wiesje, additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, Wu, Liyong, additional, and Xie, Kexin, additional

Published
2024
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28. Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease

Author

Hata, Saori, Omori, Chiori, Kimura, Ayano, Saito, Haruka, Kimura, Nobuyuki, Gupta, Veer, Pedrini, Steve, Hone, Eugene, Chatterjee, Pratishtha, Taddei, Kevin, Kasuga, Kensaku, Ikeuchi, Takeshi, Waragai, Masaaki, Nishimura, Masaki, Hu, Anqi, Nakaya, Tadashi, Meijer, Laurent, Maeda, Masahiro, Yamamoto, Tohru, Masters, Colin L., Rowe, Chris C., Ames, David, Yamamoto, Kazuo, Martins, Ralph N., Gandy, Sam, and Suzuki, Toshiharu

Published
2019
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29. Polygenic effects on the risk of Alzheimer′s disease in the Japanese population

Author

Kikuchi, Masataka, primary, Miyashita, Akinori, additional, Hara, Norikazu, additional, Kasuga, Kensaku, additional, Saito, Yuko, additional, Murayama, Shigeo, additional, Kakita, Akiyoshi, additional, Akatsu, Hiroyasu, additional, Ozaki, Kouichi, additional, Niida, Shumpei, additional, Kuwano, Ryozo, additional, Iwatsubo, Takeshi, additional, Nakaya, Akihiro, additional, and Ikeuchi, Takeshi, additional

Published
2023
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30. Heterogenous Genetic, Clinical, and Imaging Features in Patients with Neuronal Intranuclear Inclusion Disease Carrying NOTCH2NLC Repeat Expansion

Author

Fitrah, Yusran Ady, primary, Higuchi, Yo, additional, Hara, Norikazu, additional, Tokutake, Takayoshi, additional, Kanazawa, Masato, additional, Sanpei, Kazuhiro, additional, Taneda, Tomone, additional, Nakajima, Akihiko, additional, Koide, Shin, additional, Tsuboguchi, Shintaro, additional, Watanabe, Midori, additional, Fukumoto, Junki, additional, Ando, Shoichiro, additional, Sato, Tomoe, additional, Iwafuchi, Yohei, additional, Sato, Aki, additional, Hayashi, Hideki, additional, Ishiguro, Takanobu, additional, Takeda, Hayato, additional, Takahashi, Toshiaki, additional, Fukuhara, Nobuyoshi, additional, Kasuga, Kensaku, additional, Miyashita, Akinori, additional, Onodera, Osamu, additional, and Ikeuchi, Takeshi, additional

Published
2023
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31. Polygenic effects on the risk of Alzheimer's disease in the Japanese population.

Author

Kikuchi, Masataka, Miyashita, Akinori, Hara, Norikazu, Kasuga, Kensaku, Saito, Yuko, Murayama, Shigeo, Kakita, Akiyoshi, Akatsu, Hiroyasu, Ozaki, Kouichi, Niida, Shumpei, Kuwano, Ryozo, Iwatsubo, Takeshi, Nakaya, Akihiro, Ikeuchi, Takeshi, the Alzheimer's Disease Neuroimaging Initiative, Weiner, Michael W., Mason, Sara S., Albers, Colleen S., Knopman, David, and Johnson, Kris

Subjects
DISEASE risk factors, GENETIC risk score, JAPANESE people, MONOGENIC & polygenic inheritance (Genetics), GENOME-wide association studies
Abstract

Background: Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer's disease (AD)-related phenotypes, such as biomarker abnormalities and brain atrophy, and is associated with conversion from mild cognitive impairment (MCI) to AD. However, the AD PRS has been examined mainly in Europeans, and owing to differences in genetic structure and lifestyle, it is unclear whether the same relationships between the PRS and AD-related phenotypes exist in non-European populations. In this study, we calculated and evaluated the AD PRS in Japanese individuals using genome-wide association study (GWAS) statistics from Europeans. Methods: In this study, we calculated the AD PRS in 504 Japanese participants (145 cognitively unimpaired (CU) participants, 220 participants with late mild cognitive impairment (MCI), and 139 patients with mild AD dementia) enrolled in the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) project. In order to evaluate the clinical value of this score, we (1) determined the polygenic effects on AD in the J-ADNI and validated it using two independent cohorts (a Japanese neuropathology (NP) cohort (n = 565) and the North American ADNI (NA-ADNI) cohort (n = 617)), (2) examined the AD-related phenotypes associated with the PRS, and (3) tested whether the PRS helps predict the conversion of MCI to AD. Results: The PRS using 131 SNPs had an effect independent of APOE. The PRS differentiated between CU participants and AD patients with an area under the curve (AUC) of 0.755 when combined with the APOE variants. Similar AUC was obtained when PRS calculated by the NP and NA-ADNI cohorts was applied. In MCI patients, the PRS was associated with cerebrospinal fluid phosphorylated-tau levels (β estimate = 0.235, p value = 0.026). MCI with a high PRS showed a significantly increased conversion to AD in APOE ε4 noncarriers with a hazard rate of 2.22. In addition, we also developed a PRS model adjusted for LD and observed similar results. Conclusions: We showed that the AD PRS is useful in the Japanese population, whose genetic structure is different from that of the European population. These findings suggest that the polygenicity of AD is partially common across ethnic differences. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Identification and functional characterization of novel mutations including frameshift mutation in exon 4 of CSF1R in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia

Author

Miura, Takeshi, Mezaki, Naomi, Konno, Takuya, Iwasaki, Akio, Hara, Naoyuki, Miura, Masatomo, Funayama, Michitaka, Unai, Yuki, Tashiro, Yuichi, Okita, Kenji, Kihara, Takeshi, Ito, Nobuo, Kanatsuka, Yoichi, Jones, David T., Hara, Norikazu, Ishiguro, Takanobu, Tokutake, Takayoshi, Kasuga, Kensaku, Nozaki, Hiroaki, Dickson, Dennis W., Onodera, Osamu, Wszolek, Zbigniew K., and Ikeuchi, Takeshi

Published
2018
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34. Novel Partial Deletions, Frameshift and Missense Mutations ofCSF1Rin Patents withCSF1R ‐RelatedLeukoencephalopathy

Author

Ishiguro, Takanobu, primary, Konno, Takuya, additional, Hara, Norikazu, additional, Zhu, Bin, additional, Okada, Satoshi, additional, Shibata, Mamoru, additional, Saika, Reiko, additional, Kitano, Takaya, additional, Toko, Megumi, additional, Nezu, Tomohisa, additional, Hama, Yuka, additional, Kawazoe, Tomoya, additional, Takahashi‐Iwata, Ikuko, additional, Yabe, Ichiro, additional, Sato, Kota, additional, Takeda, Hayato, additional, Toda, Shintaro, additional, Nishimiya, Jin, additional, Teduka, Toshiyuki, additional, Nozaki, Hiroaki, additional, Kasuga, Kensaku, additional, Miyashita, Akinori, additional, Onodera, Osamu, additional, and Ikeuchi, Takeshi, additional

Published
2023
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36. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

Author

Morenas-Rodríguez, Estrella, Li, Yan, Hassenstab, Jason, Laske, Christoph, Levey, Allan, Lopez, Oscar, Marsh, Jacob, Martinez, Rita, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, MountzMD, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Feederle, Regina, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Karch, Celeste M, Senda, Michio, Seyfried, Nick, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Schlepckow, Kai, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Morris, John C, Kleinberger, Gernot, Nellgard, Bengt, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Levin, Johannes, Bateman, Randall J, Haass, Christian, Network, Dominantly Inherited Alzheimer, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Franzmeier, Nicolai, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William Bill, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Xiong, Chengjie, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem, Patricio, Chua, Jasmin, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Suarez-Calvet, Marc, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Fagan, Anne M, Flores, Shaney, Fox, Nick, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Schultz, Stephanie, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Häsler, Lisa, Hellm, Cortaiga, Gordon, Brian A, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Benzinger, Tammie L S, Jack, Clifford, Jerome, Gina, Johnson, Erik, Kaeser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William Bill, Koeppe, Robert, Koudelis, Deb, and Kuder-Buletta, Elke

Subjects
Adult, Amyloid beta-Peptides, Membrane Glycoproteins, TREM2 protein, human, physiology [Cognition], diagnostic imaging [Cognitive Dysfunction], genetics [Cognitive Dysfunction], genetics [Alzheimer Disease], Middle Aged, United States, Cognition, genetics [Membrane Glycoproteins], Alzheimer Disease, Humans, genetics [Receptors, Immunologic], Cognitive Dysfunction, ddc:610, Neurology (clinical), cerebrospinal fluid [Membrane Glycoproteins], Receptors, Immunologic, diagnostic imaging [Alzheimer Disease], Biomarkers
Abstract

Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with Alzheimer's disease is still unclear. Our aim was to study associations between the dynamics of soluble TREM2, as a biomarker of TREM2 signalling, and amyloid β (Aβ) deposition, tau-related pathology, neuroimaging markers, and cognitive decline, during the progression of autosomal dominant Alzheimer's disease.We did a longitudinal analysis of data from the Dominantly Inherited Alzheimer Network (DIAN) observational study, which includes families with a history of autosomal dominant Alzheimer's disease. Participants aged over 18 years who were enrolled in DIAN between Jan 1, 2009, and July 31, 2019, were categorised as either carriers of pathogenic variants in PSEN1, PSEN2, and APP genes (n=155) or non-carriers (n=93). We measured amounts of cleaved soluble TREM2 using a novel immunoassay in CSF samples obtained every 2 years from participants who were asymptomatic (Clinical Dementia Rating [CDR]=0) and annually for those who were symptomatic (CDR>0). CSF concentrations of Aβ40, Aβ42, total tau (t-tau), and tau phosphorylated on threonine 181 (p-tau) were measured by validated immunoassays. Predefined neuroimaging measurements were total cortical uptake of Pittsburgh compound B PET (PiB-PET), cortical thickness in the precuneus ascertained by MRI, and hippocampal volume determined by MRI. Cognition was measured using a validated cognitive composite (including DIAN word list test, logical memory delayed recall, digit symbol coding test [total score], and minimental status examination). We based our statistical analysis on univariate and bivariate linear mixed effects models.In carriers of pathogenic variants, a high amyloid burden at baseline, represented by low CSF Aβ42 (β=-4·28 × 10-2 [SE 0·013], p=0·0012), but not high cortical uptake in PiB-PET (β=-5·51 × 10-3 [0·011], p=0·63), was the only predictor of an augmented annual rate of subsequent increase in soluble TREM2. Augmented annual rates of increase in soluble TREM2 were associated with a diminished rate of decrease in amyloid deposition, as measured by Aβ42 in CSF (r=0·56 [0·22], p=0·011), in presymptomatic carriers of pathogenic variants, and with diminished annual rate of increase in PiB-PET (r=-0·67 [0·25], p=0·0060) in symptomatic carriers of pathogenic variants. Presymptomatic carriers of pathogenic variants with annual rates of increase in soluble TREM2 lower than the median showed a correlation between enhanced annual rates of increase in p-tau in CSF and augmented annual rates of increase in PiB-PET signal (r=0·45 [0·21], p=0·035), that was not observed in those with rates of increase in soluble TREM2 higher than the median. Furthermore, presymptomatic carriers of pathogenic variants with rates of increase in soluble TREM2 above or below the median had opposite associations between Aβ42 in CSF and PiB-PET uptake when assessed longitudinally. Augmented annual rates of increase in soluble TREM2 in presymptomatic carriers of pathogenic variants correlated with decreased cortical shrinkage in the precuneus (r=0·46 [0·22]), p=0·040) and diminished cognitive decline (r=0·67 [0·22], p=0·0020).Our findings in autosomal dominant Alzheimer's disease position the TREM2 response within the amyloid cascade immediately after the first pathological changes in Aβ aggregation and further support the role of TREM2 on Aβ plaque deposition and compaction. Furthermore, these findings underpin a beneficial effect of TREM2 on Aβ deposition, Aβ-dependent tau pathology, cortical shrinkage, and cognitive decline. Soluble TREM2 could, therefore, be a key marker for clinical trial design and interpretation. Efforts to develop TREM2-boosting therapies are ongoing.German Research Foundation, US National Institutes of Health.

Published
2022

37. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Author

Boerwinkle, Anna H, primary, Gordon, Brian A, additional, Wisch, Julie, additional, Flores, Shaney, additional, Henson, Rachel L, additional, Butt, Omar H, additional, McKay, Nicole, additional, Chen, Charles D, additional, Benzinger, Tammie L S, additional, Fagan, Anne M, additional, Handen, Benjamin L, additional, Christian, Bradley T, additional, Head, Elizabeth, additional, Mapstone, Mark, additional, Rafii, Michael S, additional, O'Bryant, Sid, additional, Lai, Florence, additional, Rosas, H Diana, additional, Lee, Joseph H, additional, Silverman, Wayne, additional, Brickman, Adam M, additional, Chhatwal, Jasmeer P, additional, Cruchaga, Carlos, additional, Perrin, Richard J, additional, Xiong, Chengjie, additional, Hassenstab, Jason, additional, McDade, Eric, additional, Bateman, Randall J, additional, Ances, Beau M, additional, Aizenstein, Howard J, additional, Andrews, Howard F, additional, Bell, Karen, additional, Birn, Rasmus M, additional, Bulova, Peter, additional, Cheema, Amrita, additional, Chen, Kewei, additional, Clare, Isabel, additional, Clark, Lorraine, additional, Cohen, Ann D, additional, Constantino, John N, additional, Doran, Eric W, additional, Feingold, Eleanor, additional, Foroud, Tatiana M, additional, Hartley, Sigan L, additional, Hom, Christy, additional, Honig, Lawrence, additional, Ikonomovic, Milos D, additional, Johnson, Sterling C, additional, Jordan, Courtney, additional, Kamboh, M Ilyas, additional, Keator, David, additional, Klunk MD, William E, additional, Kofler, Julia K, additional, Kreisl, William C, additional, Krinsky- McHale, Sharon J, additional, Lao, Patrick, additional, Laymon, Charles, additional, Lott, Ira T, additional, Lupson, Victoria, additional, Mathis, Chester A, additional, Minhas, Davneet S, additional, Nadkarni, Neelesh, additional, Pang, Deborah, additional, Petersen, Melissa, additional, Price, Julie C, additional, Pulsifer, Margaret, additional, Reiman, Eric, additional, Rizvi, Batool, additional, Sabbagh, Marwan N, additional, Schupf, Nicole, additional, Tudorascu, Dana L, additional, Tumuluru, Rameshwari, additional, Tycko, Benjamin, additional, Varadarajan, Badri, additional, White, Desiree A, additional, Yassa, Michael A, additional, Zaman, Shahid, additional, Zhang, Fan, additional, Adams, Sarah, additional, Allegri, Ricardo, additional, Araki, Aki, additional, Barthelemy, Nicolas, additional, Bechara, Jacob, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William, additional, Brosch, Jared, additional, Buck, Jill, additional, Buckles, Virginia, additional, Carter, Kathleen, additional, Cash, Lisa, additional, Mendez, Patricio C, additional, Chua, Jasmin, additional, Chui, Helena, additional, Courtney, Laura, additional, Day, Gregory, additional, DeLaCruz, Chrismary, additional, Denner, Darcy, additional, Diffenbacher, Anna, additional, Dincer, Aylin, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Duong, Duc, additional, Egido, Noelia, additional, Esposito, Bianca, additional, Farlow, Marty, additional, Feldman, Becca, additional, Fitzpatrick, Colleen, additional, Fox, Nick, additional, Franklin, Erin, additional, Joseph-Mathurin, Nelly, additional, Fujii, Hisako, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldberg, Sarah, additional, Goldman, Jill, additional, Gonzalez, Alyssa, additional, Gräber-Sultan, Susanne, additional, Graff-Radford, Neill, additional, Graham, Morgan, additional, Gray, Julia, additional, Gremminger, Emily, additional, Grilo, Miguel, additional, Groves, Alex, additional, Haass, Christian, additional, Häslerc, Lisa, additional, Hellm, Cortaiga, additional, Herries, Elizabeth, additional, Hoechst-Swisher, Laura, additional, Hofmann, Anna, additional, Holtzman, David, additional, Hornbeck, Russ, additional, Igor, Yakushev, additional, Ihara, Ryoko, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Ishii, Kenji, additional, Jack, Clifford, additional, Jerome, Gina, additional, Johnson, Erik, additional, Jucker, Mathias, additional, Karch, Celeste, additional, Käser, Stephan, additional, Kasuga, Kensaku, additional, Keefe, Sarah, additional, Klunk, William, additional, Koeppe, Robert, additional, Koudelis, Deb, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Levey, Allan, additional, Levin, Johannes, additional, Li, Yan, additional, Lopez, Oscar, additional, Marsh, Jacob, additional, Martins, Ralph, additional, Mason, Neal S, additional, Masters, Colin, additional, Mawuenyega, Kwasi, additional, McCullough, Austin, additional, Mejia, Arlene, additional, Morenas-Rodriguez, Estrella, additional, Morris, John C, additional, Mountz, James, additional, Mummery, Catherine, additional, Nagamatsu, Akemi, additional, Neimeyer, Katie, additional, Niimi, Yoshiki, additional, Noble, James, additional, Norton, Joanne, additional, Nuscher, Brigitte, additional, Obermüller, Ulricke, additional, O'Connor, Antoinette, additional, Patira, Riddhi, additional, Ping, Lingyan, additional, Preische, Oliver, additional, Renton, Alan, additional, Ringman, John, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Senda, Michio, additional, Seyfried, Nicholas T, additional, Shady, Kristine, additional, Shimada, Hiroyuki, additional, Sigurdson, Wendy, additional, Smith, Jennifer, additional, Smith, Lori, additional, Snitz, Beth, additional, Sohrabi, Hamid, additional, Stephens, Sochenda, additional, Taddei, Kevin, additional, Thompson, Sarah, additional, Vöglein, Jonathan, additional, Wang, Peter, additional, Wang, Qing, additional, Weamer, Elise, additional, Xu, Jinbin, additional, and Xu, Xiong, additional

Published
2023
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38. Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment

Author

Ikeuchi, Takeshi, primary, Kanda, Mayuka, additional, Kitamura, Hitomi, additional, Morikawa, Fumiyoshi, additional, Toru, Shuta, additional, Nishimura, Chika, additional, Kasuga, Kensaku, additional, Tokutake, Takayoshi, additional, Takahashi, Tetsuya, additional, Kuroha, Yasuko, additional, Miyazawa, Nobuhiko, additional, Tanaka, Shin, additional, Utsumi, Kumiko, additional, Ono, Kenjiro, additional, Yano, Satoshi, additional, Hamano, Tadanori, additional, Naruse, Satoshi, additional, Yajima, Ryuji, additional, Kawashima, Noriko, additional, Kaneko, Chikako, additional, Tachibana, Hisatsugu, additional, Yano, Yuki, additional, Kato, Yumiko, additional, Toue, Sakino, additional, Jinzu, Hiroko, additional, Kitamura, Akihiko, additional, Yokoyama, Yuri, additional, Kaneko, Eiji, additional, Yamakado, Minoru, additional, and Nagao, Kenji, additional

Published
2022
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39. Estimation of blood-based biomarkers of glial activation related to neuroinflammation

Author

Yasuno, Fumihiko, primary, Watanabe, Atsushi, additional, Kimura, Yasuyuki, additional, Yamauchi, Yumeka, additional, Ogata, Aya, additional, Ikenuma, Hiroshi, additional, Abe, Junichiro, additional, Minami, Hiroyuki, additional, Nihashi, Takashi, additional, Yokoi, Kastunori, additional, Hattori, Saori, additional, Shimoda, Nobuyoshi, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, Takeda, Akinori, additional, Sakurai, Takashi, additional, Ito, Kengo, additional, and Kato, Takashi, additional

Published
2022
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40. Biomarkers and neuropathology in posterior cortical atrophy: an international, multi‐site study

Author

Chapleau, Marianne, primary, La Joie, Renaud, additional, Mundada, Nidhi S., additional, Fumagalli, Giorgio G, additional, Formaglio, Maïté, additional, Grinberg, Lea Tenenholz, additional, Hromas, Gabrielle, additional, Kasuga, Kensaku, additional, Lacombe‐Thibault, Mégane, additional, Levin, Netta, additional, Lladó, Albert, additional, Miklitz, Carolin, additional, Perani, Daniela, additional, Rodriguez‐Porcel, Federico, additional, Seeley, William W., additional, Spina, Salvatore, additional, Tousi, Babak, additional, Vandenberghe, Rik, additional, Walker, Jamie M., additional, Wu, Liyong, additional, Yong, Keir X X, additional, Pelak, Victoria S, additional, Ossenkoppele, Rik, additional, and Rabinovici, Gil D., additional

Published
2022
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41. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease

Author

Horie, Kanta, Li, Yan, Allegri, Ricardo, Mendez, Patricio Chrem, Ikeuchi, Takeshi, Kasuga, Kensaku, Noble, James, Farlow, Martin, Chhatwal, Jasmeer, Day, Gregory S, Schofield, Peter R, Masters, Colin L, Barthélemy, Nicolas R, Levin, Johannes, Jucker, Mathias, Lee, Jae-Hong, Roh, Jee Hoon, Sato, Chihiro, Sachdev, Pallavi, Koyama, Akihiko, Reyderman, Larisa, Bateman, Randall J, McDade, Eric, Gordon, Brian A, Network, Dominantly Inherited Alzheimer, Hassenstab, Jason, Benzinger, Tammie L S, Fagan, Anne M, Morris, John C, Karch, Celeste M, and Xiong, Chengjie

Subjects
Neurology, Neurology (clinical), ddc:610
Abstract

Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer disease related neurofibrillary tau pathological changes. We examined CSF MTBR-tau species in dominantly inherited Alzheimer disease (DIAD) mutation carriers to assess the association with AD biomarkers and clinical symptoms.Cross-sectional and longitudinal CSF from 229 DIAD mutation and 130 mutation non-carriers had sequential characterization of N-terminal/mid-domain phosphorylated tau (p-tau) followed by MTBR-tau species and tau-PET, other soluble tau and amyloid biomarkers, comprehensive clinical and cognitive assessments, and brain magnetic resonance imaging of atrophy.CSF MTBR-tau species located within the putative 'border' region and one species corresponding to the 'core' region of aggregates in neurofibrillary tangles increased during the presymptomatic stage and decreased during the symptomatic stage. The 'border' MTBR-tau species were associated with amyloid pathology and CSF p-tau; while the 'core' MTBR-tau species were associated stronger with tau-PET and CSF measures of neurodegeneration. The ratio of the border to the core species provided a continuous measure of increasing amounts that tracked clinical progression and NFT.Changes in CSF soluble MTBR-tau species preceded the onset of dementia, tau tangle increase, and atrophy in DIAD. The ratio of 4R-specific MTBR-tau (border) to the NFT (core) MTBR-tau species corresponds to the pathology of NFT in DIAD and change with disease progression. The dynamics between different MTBR-tau species in the CSF may serve as a marker of tau-related disease progression and target engagement of anti-tau therapeutics. This article is protected by copyright. All rights reserved.

Published
2023

43. Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study

Author

Yasuno, Fumihiko, primary, Kimura, Yasuyuki, additional, Ogata, Aya, additional, Ikenuma, Hiroshi, additional, Abe, Junichiro, additional, Minami, Hiroyuki, additional, Nihashi, Takashi, additional, Yokoi, Kastunori, additional, Hattori, Saori, additional, Shimoda, Nobuyoshi, additional, Watanabe, Atsushi, additional, Kasuga, Kensaku, additional, Ikeuchi, Takeshi, additional, Takeda, Akinori, additional, Sakurai, Takashi, additional, Ito, Kengo, additional, and Kato, Takashi, additional

Published
2022
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44. The Clinical Application of Optimized AT(N) Classification in Alzheimer’s Clinical Syndrome (ACS) and non-ACS Conditions

Author

Kasuga, Kensaku, primary, Tsukie, Tamao, additional, Kikuchi, Masataka, additional, Tokutake, Takayoshi, additional, Washiyama, Kazuo, additional, Simizu, Soichiro, additional, Yoshizawa, Hiroshi, additional, Kuroha, Yasuko, additional, Yajima, Ryuji, additional, Mori, Hiroshi, additional, Arakawa, Yasuaki, additional, Onda, Kiyoshi, additional, Miyashita, Akinori, additional, Onodera, Osamu, additional, Iwatsubo, Takeshi, additional, and Ikeuchi, Takeshi, additional

Published
2022
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45. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation

Author

Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Sus, (Bill) Brooks, William, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem Mendez, Patricio, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gr¨aber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, H¨asler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, K¨aser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Scott Mason, Neal, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O’Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, V¨oglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Hernández, Damián, Morgan Schlicht, Stephanie, Elli Clarke, Jordan, Daniszewski, Maciej, Karch, Celeste M., Goate, Alison M., and Pébay, Alice

Published
2024
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46. Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid

Author

Kasuga, Kensaku, primary, Kikuchi, Masataka, additional, Tsukie, Tamao, additional, Suzuki, Kazushi, additional, Ihara, Ryoko, additional, Iwata, Atsushi, additional, Hara, Norikazu, additional, Miyashita, Akinori, additional, Kuwano, Ryozo, additional, Iwatsubo, Takeshi, additional, and Ikeuchi, Takeshi, additional

Published
2022
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47. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease

Author

Millar, Peter R., primary, Luckett, Patrick H., additional, Gordon, Brian A., additional, Benzinger, Tammie L.S., additional, Schindler, Suzanne E., additional, Fagan, Anne M., additional, Cruchaga, Carlos, additional, Bateman, Randall J., additional, Allegri, Ricardo, additional, Jucker, Mathias, additional, Lee, Jae-Hong, additional, Mori, Hiroshi, additional, Salloway, Stephen P, additional, Yakushev, Igor, additional, Morris, John C., additional, Ances, Beau M., additional, Adams, Sarah, additional, Araki, Aki, additional, Barthelemy, Nicolas, additional, Bateman, Randall, additional, Bechara, Jacob, additional, Benzinger, Tammie, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William (Bill), additional, Brosch, Jared, additional, Buck, Jill, additional, Buckles, Virginia, additional, Carter, Kathleen, additional, Cash, Lisa, additional, Chen, Charlie, additional, Chhatwal, Jasmeer, additional, Mendez, Patricio Chrem, additional, Chua, Jasmin, additional, Chui, Helena, additional, Courtney, Laura, additional, Day, Gregory S, additional, DeLaCruz, Chrismary, additional, Denner, Darcy, additional, Diffenbacher, Anna, additional, Dincer, Aylin, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Duong, Duc, additional, Egido, Noelia, additional, Esposito, Bianca, additional, Fagan, Anne, additional, Farlow, Marty, additional, Feldman, Becca, additional, Fitzpatrick, Colleen, additional, Flores, Shaney, additional, Fox, Nick, additional, Franklin, Erin, additional, Joseph-Mathurin, Nelly, additional, Fujii, Hisako, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldberg, Sarah, additional, Goldman, Jill, additional, Gonzalez, Alyssa, additional, Gordon, Brian, additional, Gräber-Sultan, Susanne, additional, Graff-Radford, Neill, additional, Graham, Morgan, additional, Gray, Julia, additional, Gremminger, Emily, additional, Grilo, Miguel, additional, Groves, Alex, additional, Haass, Christian, additional, Häsler, Lisa, additional, Hassenstab, Jason, additional, Hellm, Cortaiga, additional, Herries, Elizabeth, additional, Hoechst-Swisher, Laura, additional, Hofmann, Anna, additional, Holtzman, David, additional, Hornbeck, Russ, additional, Igor, Yakushev, additional, Ihara, Ryoko, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Ishii, Kenji, additional, Jack, Clifford, additional, Jerome, Gina, additional, Johnson, Erik, additional, Karch, Celeste, additional, Käser, Stephan, additional, Kasuga, Kensaku, additional, Keefe, Sarah, additional, Klunk, William, additional, Koeppe, Robert, additional, Koudelis, Deb, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Levey, Allan, additional, Levin, Johannes, additional, Li, Yan, additional, Lopez, Oscar, additional, Marsh, Jacob, additional, Martins, Ralph, additional, Mason, Neal Scott, additional, Masters, Colin, additional, Mawuenyega, Kwasi, additional, McCullough, Austin, additional, McDade, Eric, additional, Mejia, Arlene, additional, Morenas-Rodriguez, Estrella, additional, Morris, John, additional, Mountz, James, additional, Mummery, Cath, additional, Nadkarni, N eelesh, additional, Nagamatsu, Akemi, additional, Neimeyer, Katie, additional, Niimi, Yoshiki, additional, Noble, James, additional, Norton, Joanne, additional, Nuscher, Brigitte, additional, Obermüller, Ulricke, additional, O'Connor, Antoinette, additional, Patira, Riddhi, additional, Perrin, Richard, additional, Ping, Lingyan, additional, Preische, Oliver, additional, Renton, Alan, additional, Ringman, John, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Senda, Michio, additional, Seyfried, Nicholas T, additional, Shady, Kristine, additional, Shimada, Hiroyuki, additional, Sigurdson, Wendy, additional, Smith, Jennifer, additional, Smith, Lori, additional, Snitz, Beth, additional, Sohrabi, Hamid, additional, Stephens, Sochenda, additional, Taddei, Kevin, additional, Thompson, Sarah, additional, Vöglein, Jonathan, additional, Wang, Peter, additional, Wang, Qing, additional, Weamer, Elise, additional, Xiong, Chengjie, additional, Xu, Jinbin, additional, and Xu, Xiong, additional

Published
2022
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48. The role of dyadic cognitive report and subjective cognitive decline in early ADRD clinical research and trials: current knowledge, gaps, and recommendations

Author

Universidade de Santiago de Compostela. Departamento de Psicoloxía Evolutiva e da Educación, Nosheny, Rachel, Amariglio, Rebecca, Sikkes, Sietske, Van Hulle, Carol, Bicalho, Maria Aparecida Camargos, Dowling, N. Maritza, Dozzi Brucki, Sonia Maria, Ismail, Zahinoor, Kasuga, Kensaku, Kuhn, Elizabeth, Numbers, Katya, Aaronson, Anna, Moretti, Davide Vito, Pereiro Rozas, Arturo José, Sánchez-Benavides, Gonzalo, SELLEK RODRIGUEZ, ALLIS FELIPE, Urwyler, Prabitha, Zawaly, Kristina, Dyadic Patterns of Subjective Reportworking group within the Subjective Cognitive Decline Professional Interest Area, Alzheimer’s Association ISTAART, Universidade de Santiago de Compostela. Departamento de Psicoloxía Evolutiva e da Educación, Nosheny, Rachel, Amariglio, Rebecca, Sikkes, Sietske, Van Hulle, Carol, Bicalho, Maria Aparecida Camargos, Dowling, N. Maritza, Dozzi Brucki, Sonia Maria, Ismail, Zahinoor, Kasuga, Kensaku, Kuhn, Elizabeth, Numbers, Katya, Aaronson, Anna, Moretti, Davide Vito, Pereiro Rozas, Arturo José, Sánchez-Benavides, Gonzalo, SELLEK RODRIGUEZ, ALLIS FELIPE, Urwyler, Prabitha, Zawaly, Kristina, and Dyadic Patterns of Subjective Reportworking group within the Subjective Cognitive Decline Professional Interest Area, Alzheimer’s Association ISTAART

Abstract

Efficient identification of cognitive decline and Alzheimer’s disease (AD) risk in early stages of the AD disease continuum is a critical unmet need. Subjective cognitive decline is increasingly recognized as an early symptomatic stage of AD. Dyadic cognitive report, including subjective cognitive complaints (SCC) from a participant and an informant/study partner who knows the participant well, represents an accurate, reliable, and efficient source of data for assessing risk. However, the separate and combined contributions of self- and study partner report, and the dynamic relationship between the two, remains unclear. The Subjective Cognitive Decline Professional Interest Area within the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment convened a working group focused on dyadic patterns of subjective report. Group members identified aspects of dyadic-report information important to the AD research field, gaps in knowledge, and recommendations. By reviewing existing data on this topic, we found evidence that dyadic measures are associated with objective measures of cognition and provide unique information in preclinical and prodromal AD about disease stage and progression and AD biomarker status. External factors including dyad (participant–study partner pair) relationship and sociocultural factors contribute to these associations. We recommend greater dyad report use in research settings to identify AD risk. Priority areas for future research include (1) elucidation of the contributions of demographic and sociocultural factors, dyad type, and dyad relationship to dyad report; (2) exploration of agreement and discordance between self- and study partner report across theADsyndromic and disease continuum; (3) identification of domains (e.g., memory, executive function, neuropsychiatric) that predict AD risk outcomes and differentiate cognitive impairment due to AD from other impairment; (4) development of best practices for

Published
2022

50. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease

Author

Millar, Peter R, Luckett, Patrick H, Lee, Jaehyun, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, Mori, Hiroshi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, N Eelesh, Nagamatsu, Akemi, Neimeyer, Katie, Salloway, Stephen P, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Yakushev, Igor, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Morris, John C, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Ances, Beau M, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Network, Dominantly Inherited Alzheimer, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Gordon, Brian A, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William Bill, Brosch, Jared, Buck, Jill, Benzinger, Tammie L S, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Mendez, Patricio Chrem, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Schindler, Suzanne E, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne M, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Bateman, Randall J, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häsler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Jucker, Mathias, Johnson, Erik, Karch, Celeste, Kaeser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, and Kuder-Buletta, Elke

Subjects
Adult, Aged, 80 and over, Adolescent, Resting-state functional connectivity, Cognitive Neuroscience, fMRI, Brain, Neuroimaging, Middle Aged, Magnetic Resonance Imaging, pathology [Alzheimer Disease], Young Adult, physiology [Brain], methods [Magnetic Resonance Imaging], Neurology, Brain aging, Alzheimer Disease, Machine learning, Humans, ddc:610, Alzheimer disease, Biomarkers, Aged
Abstract

"Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories. Advanced brain-predicted age has been well established in symptomatic Alzheimer disease (AD), but is underexplored in preclinical AD. Prior brain-predicted age studies have typically used structural MRI, but resting-state functional connectivity (FC) remains underexplored. Our model predicted age from FC in 391 cognitively normal, amyloid-negative controls (ages 18-89). We applied the trained model to 145 amyloid-negative, 151 preclinical AD, and 156 symptomatic AD participants to test group differences. The model accurately predicted age in the training set. FC-predicted brain age gaps (FC-BAG) were significantly older in symptomatic AD and significantly younger in preclinical AD compared to controls. There was minimal correspondence between networks predictive of age and AD. Elevated FC-BAG may reflect network disruption during symptomatic AD. Reduced FC-BAG in preclinical AD was opposite to the expected direction, and may reflect a biphasic response to preclinical AD pathology or may be driven by inconsistency between age-related vs. AD-related networks. Overall, FC-predicted brain age may be a sensitive AD biomarker.

Published
2022

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