236 results on '"Küpper, Jan-Heiner"'
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2. OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects
3. Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery
4. Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells
5. Synthesis of mono Cytochrome P450 in a modified CHO-CPR cell-free protein production platform
6. Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells
7. Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells
8. Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4
9. In vitro simulation of the liver first-pass effect with biotransformation-competent HepG2 cells to study effects of MG-132 on liver and cancer cells.
10. Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies
11. The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells
12. Anti-Cancer Prodrug Cyclophosphamide Exerts Thrombogenic Effects on Human Venous Endothelial Cells Independent of CYP450 Activation—Relevance to Thrombosis
13. Real time monitoring of oxygen uptake of hepatocytes in a microreactor using optical microsensors
14. Synthesis of cyclophosphamide metabolites by a peroxygenase from Marasmius rotula for toxicological studies on human cancer cells
15. Light-induced changes in the morphology and fluorescence of Arthrospira platensis
16. Lipophilic and Hydrophilic Compounds from Arthrospira platensis and Its Effects on Tissue and Blood Cells—An Overview
17. Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines
18. Influence of Different Light-Emitting Diode Colors on Growth and Phycobiliprotein Generation of Arthrospira platensis
19. The chemical structure impairs the intensity of genotoxic effects promoted by 1,2-unsaturated pyrrolizidine alkaloids in vitro
20. Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells
21. Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter
22. Modeling atrial fibrosis in vitro—Generation and characterization of a novel human atrial fibroblast cell line
23. Angewandte Tumorvirologie
24. Applied Tumor Virology
25. Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo
26. Inhibition of phase-1 biotransformation and cytostatic effects of diphenyleneiodonium on hepatoblastoma cell line HepG2 and a CYP3A4-overexpressing HepG2 cell clone
27. Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation
28. Poly(ADP-ribose) polymerase activity in intact or permeabilized leukocytes from mammalian species of different longevity
29. Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity
30. Expression of the DNA-Binding Domain of Human Poly(ADP-Ribose) Polymerase as a Trans-Dominant Inhibitor of Poly(ADP-Ribosyl)ation in Transfected Eucaryotic Cell Lines
31. List of Contributors
32. Tumor-Associated Autoantibodies
33. Morphology and Growth of Arthrospira platensis during Cultivation in a Flat-Type Bioreactor
34. Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells
35. Metabolic Pattern of Hepatotoxic Pyrrolizidine Alkaloids in Liver Cells
36. Namibian algae species: A review of their distribution, medicinal uses and chemical constituents
37. Potential Effects of Nonadherent on Adherent Human Umbilical Venous Endothelial Cells in Cell Culture
38. Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies
39. Effect of Prostanoids on Human Platelet Function: An Overview
40. Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: Evidence for increased tumor cell apoptosis in vivo
41. Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme
42. HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells
43. Factors influencing the growth of Spirulina platensis in closed photobioreactors under CO2 – O2 conversion
44. NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies
45. Brivanib Exhibits Potential for Pharmacokinetic Drug–Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes
46. Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry
47. Improved protocols for the isolation and in-situ cryopreservation of cell colonies
48. Comparative analysis of inducible expression systems in transient transfection studies
49. Glucocorticoid Hormone Stimulates Mitochondrial Biogenesis Specifically in Skeletal Muscle
50. Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro
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