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Androgen receptor (AR) drives prostate cancer (PC) growth and progression, and targeting AR signaling is the mainstay of pharmacological therapies for PC. Resistance develops relatively fast as a result of refueled AR activity. A major gap in the field is the lack of understanding of targetable mechanisms that induce persistent AR expression in castrate-resistant PC (CRPC). This study uncovers an unexpected function of active Stat5 signaling, a known promoter of PC growth and clinical progression, as a potent inducer of AR gene transcription. Stat5 suppression inhibited AR gene transcription in preclinical PC models and reduced the levels of wild-type, mutated, and truncated AR proteins. Pharmacological Stat5 inhibition by a specific small-molecule Stat5 inhibitor down-regulated Stat5-inducible genes as well as AR and AR-regulated genes and suppressed PC growth. This work introduces the concept of Stat5 as an inducer of AR gene transcription in PC. Pharmacological Stat5 inhibitors may represent a new strategy for suppressing AR and CRPC growth.

Visual exploration paradigms involving object arrays have been used to examine salience of social stimuli such as faces in ASD. Recent work suggests performance on these paradigms may associate with clinical features of ASD. We evaluate metrics from a visual exploration paradigm in 4-to-11-year-old children with ASD (n = 23; 18 males) and typical development (TD; n = 23; 13 males). Presented with arrays containing faces and nonsocial stimuli, children with ASD looked less at (p = 0.002) and showed fewer fixations to (p = 0.022) faces than TD children, and spent less time looking at each object on average (p = 0.004). Attention to the screen and faces correlated positively with social and cognitive skills in the ASD group (ps < 0.05). This work furthers our understanding of objective measures of visual exploration in ASD and its potential for quantifying features of ASD.

We examined development of 5- and 10.5-month-old infants' face representations, focusing on infants' discrimination and categorization of female and male faces. We tested for gender-based preferences and categorization of female and male faces by presenting infants with pairs of faces and then habituating them to a series of majority female or male face ensembles. We then tested for gender preferences with new face pairs (one female and one male; Study 1) or new face ensembles (majority female and majority male; Study 2). We found that both 5- and 10.5-month-old infants discriminated female from male faces in face pairs, and both age groups looked more at female faces during habituation. Neither age group, however, provided evidence of gender-based categorization. We interpret these findings within a theoretical framework that stresses environmental exposure to different social categories, and infants' ability to detect commonalities of features within categories. We conclude that infants' gender-based categorization of faces is constrained by the set of features available in the input.

Mental rotation (MR) is the ability to transform a mental representation of an object so as to accurately predict how the object would look from a different angle (Sci 171:701-703, 1971), and it is involved in a number of important cognitive and behavioral activities. In this review we discuss recent studies that have examined MR in infants and the development of MR across the first year after birth. These studies have produced many conflicting results, yet several tentative conclusions can be reached. First, MR may be operational in infants as young as 3 months of age. Second, there may be sex differences in MR performance in infancy, in general favoring males, as there are in children and in adults. Third, there appear to be multiple influences on infants' MR performance, including infants' motor activity, stimulus or task complexity, hormones, and parental attitudes. We conclude by calling for additional research to examine more carefully the causes and consequences of MR abilities early in life.

Academic buoyancy (AB) is the ability to overcome minor academic setbacks. However, although it seems as though teachers would be well placed to comment on this characteristic in students, no teacher-report measure of AB exists. This study evaluates a teacher-report version of the widely used, student-report, Academic Buoyancy Scale (ABS). Confirmatory factor analysis supported the unifactorial nature of the Teacher Academic Buoyancy Scale (TABS), and the scale showed excellent internal reliability. However, while there was some evidence for the criterion-related validity of the TABS, it showed very poor convergent validity with the ABS. It also correlated better with academic achievement than should theoretically be the case for a measure of AB. Further, AB estimates from the two measures were moderated by demographic characteristics: teachers rated girls and those not facing adversity as more buoyant, but the opposite was the case for self-reports. In sum, this study suggests a significant disjunction between teacher- and self-reports of AB, and that teacher estimates of AB are likely to be affected by salient, non-AB-related, student characteristics.

Psychological scientists have become increasingly concerned with issues related to methodology and replicability, and infancy researchers in particular face specific challenges related to replicability: For example, high-powered studies are difficult to conduct, testing conditions vary across labs, and different labs have access to different infant populations. Addressing these concerns, we report on a large-scale, multisite study aimed at (a) assessing the overall replicability of a single theoretically important phenomenon and (b) examining methodological, cultural, and developmental moderators. We focus on infants’ preference for infant-directed speech (IDS) over adult-directed speech (ADS). Stimuli of mothers speaking to their infants and to an adult in North American English were created using seminaturalistic laboratory-based audio recordings. Infants’ relative preference for IDS and ADS was assessed across 67 laboratories in North America, Europe, Australia, and Asia using the three common methods for measuring infants’ discrimination (head-turn preference, central fixation, and eye tracking). The overall meta-analytic effect size (Cohen’s d) was 0.35, 95% confidence interval = [0.29, 0.42], which was reliably above zero but smaller than the meta-analytic mean computed from previous literature (0.67). The IDS preference was significantly stronger in older children, in those children for whom the stimuli matched their native language and dialect, and in data from labs using the head-turn preference procedure. Together, these findings replicate the IDS preference but suggest that its magnitude is modulated by development, native-language experience, and testing procedure.

Diminished attention to socially relevant information appears to be an early emerging risk factor associated with autism spectrum disorders (ASD). However, inconsistencies across studies suggest that atypicalities in visual social attention in infants at high-risk for ASD during the first postnatal year may be subtle and more apparent under certain contexts. Here we explore factors that may moderate developmental trajectories in attention to faces, including the social complexity of the dynamic visual stimuli used to measure visual social attention and the early social environment of the infant as indexed by parental affectedness of ASD-related traits. Across infants at both high (HR) and low risk for ASD, attention to faces increased during the first postnatal year, with overall greater attention being allocated to schematic faces in the simpler video stimulus. Moreover, greater parental affectedness of ASD-related traits was associated with reduced developmental gains in attention to faces. For HR infants, greater attention to faces was positively associated with social communicative competence, including better joint attention skills and lower social impairments. Altogether, our findings highlight the importance of considering developmental level when selecting stimuli to longitudinally examine visual social attention, and the clinical relevance of including measures of infant's social environment in understanding early markers of ASD risk. Autism Res 2019, 12: 445-457 © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Attention to faces is an important means for infants to learn about the social world. The complexity of the social scene and an infant's early social environment both affect the amount of time infants at high- and low-risk for ASD look at faces during the first postnatal year. For infants at high-risk for ASD, greater attention to faces was associated with better social skills. Understanding an infant's social environment may have a positive impact on social communicative development.

Mental rotation (MR) is an important feature of spatial cognition invoking mental imagery of an object's appearance when viewed from a new orientation. Prior studies have revealed evidence of MR in infants, including a sex difference similar to that detected in older populations. Some of these studies used visual habituation methods whereby infants were familiarized with an object rotating through a 240° angle, followed by test trials showing either the habituation object or a mirror image object rotating through the previously unseen 120° angle. Significantly longer looking at either of these objects was taken to reflect infants' ability to recognize the habituation object even when seen from a novel viewpoint, suggesting the capacity for MR. However, these infants' responses could, in theory, be explained with reference to perceptual discrimination rather than MR, because the views of the habituation and test objects were very similar in some video frames. In the current study, we observed a diverse population of 5-month-olds (24 females, 24 males) for evidence of MR through 30° of arc. In this more challenging test, our stimuli left a 30° gap angle between critical video frames representing the habituation and test objects. Consistent with earlier reports, we found that relative to female infants, male infants looked significantly longer at the mirror image test stimulus immediately following habituation. These results add to an emerging consensus that some young infants are capable of MR, and that male and female infants on average behave differently in this type of MR task. [ABSTRACT FROM AUTHOR]

We asked whether 11- and 14- month-old infants' abstract rule learning, an early form of analogical reasoning, is susceptible to processing constraints imposed by limits in attention and memory for sequence position. We examined 11- and 14- month-old infants' learning and generalization of abstract repetition rules ("repetition anywhere," Experiment 1 or "medial repetition," Experiment 2) and ordering of specific items (edge positions, Experiment 3) in 4-item sequences. Infants were habituated to sequences containing repetition- and/or position-based structure and then tested with "familiar" vs. "novel" (random) sequences composed of new items. Eleven-month-olds (N = 40) failed to learn abstract repetition rules, but 14-month-olds (N = 40) learned rules under both conditions. In Experiment 3, 11-month-olds (N = 20) learned item edge positions in sequences identical to those in Experiment 2. We conclude that infant sequence learning is constrained by item position in similar ways as in adults.

We examined mechanisms underlying infants' ability to categorize human biological motion stimuli from sex-typed walk motions, focusing on how visual attention to dynamic information in point-light displays (PLDs) contributes to infants' social category formation. We tested for categorization of PLDs produced by women and men by habituating infants to a series of female or male walk motions and then recording posthabituation preferences for new PLDs from the familiar or novel category (Experiment 1). We also tested for intrinsic preferences for female or male walk motions (Experiment 2). We found that infant boys were better able to categorize PLDs than were girls and that male PLDs were preferred overall. Neither of these effects was found to change with development across the observed age range (∼4-18 months). We conclude that infants' categorization of walk motions in PLDs is constrained by intrinsic preferences for higher motion speeds and higher spans of motion and, relatedly, by differences in walk motions produced by men and women.

Compared to monolinguals, bilingual children attend more to pragmatic cues, especially when they conflict with perceptualcues (Brojde et al., 2012). This longitudinal eye-tracking study investigated monolingual and bilingual two-year-olds (T1M age=24.3 months; T2 M age=27.6 months) visual attention in a word learning paradigm containing a conflict betweeneye gaze (pragmatic cue) and object salience (perceptual cue). Participants saw videos of a model looked looking at andlabeling either a salient or a nonsalient object. Next, participants saw the objects from the videos side-by-side onscreen, andheard either the target label or a novel distracter label. At T1, monolinguals (N=14) and bilinguals (N=10) showed similarlooking patterns during learning; at test, bilinguals modulated their looking to target and distracter objects differently thanmonolinguals. At T2, monolinguals and bilinguals showed similar looking patterns during all trials. These results suggestthat language background may differentially influence word learning and visual attention across development.

We recorded visual attention to same- and other-race faces in Hispanic and White 11-month-old infants, an age at which face processing is presumably biased by an own-race recognition advantage. Infants viewed pairs of faces differing in race or ethnicity as their eye movements were recorded. We discovered consistently greater attention to Black over Hispanic faces, to Black faces over White faces, and to Hispanic over White faces. Inversion of face stimuli, and infant ethnicity, had little effect on performance. Infants' social environments, however, differed sharply according to ethnicity: Hispanic infants are almost exclusively exposed to Hispanic family members, and White infants to White family members. Moreover, Hispanic infants inhabit communities that are more racially and ethnically diverse. These results imply that race-based visual attention in infancy is closely aligned with the larger society's racial and ethnic composition, as opposed to race-based recognition, which is more closely aligned with infants' immediate social environments.

We examined mechanisms underlying infants’ ability todetect, extract, and generalize sequential patterns, focusing onhow saliency and consistency of distributional informationguide infant learning of the most “likely” pattern inaudiovisual sequences. In Experiment 1, we asked if 11- and14-month-old infants could learn a “repetition anywhere” rule(e.g., ABBC, AABC, ABCC). In Experiment 2 we asked if11- and 14-month-olds could generalize a “medial repetition”rule when its position is consistent in sequence, and inExperiment 3 we asked if 11-month-olds could identify anonadjacent dependency occurring at edge positions. Infantswere first habituated to 4-item sequences (shapes + syllables)containing repetition- and/or position-based structure, andwere then tested with “familiar” structure instantiated acrossnew items or combinations of items vs. “novel” (random)sequences. We found that 11-month-olds failed to learn therepetition rule both when the structure appeared in initial,medial, or final position (Experiment 1) and when it wasrestricted to the medial position (Experiment 2). Fourteen-month-olds learned repetition rules under both conditions.Finally, in Experiment 3 11-month-olds succeeded in learninga nonadjacent dependency in sequences identical to thoseused to test repetition learning in Experiment 2. Our resultssuggest that infants at 11 months, like adults, are relativelyinsensitive to patterns in the middle of sequences.

Developing understanding of fractions involves connections between nonsymbolic visual representations and symbolic representations. Initially, teachers introduce fraction concepts with visual representations before moving to symbolic representations. Once the focus is shifted to symbolic representations, the connections between visual representations and symbolic notation are considered to be less useful, and students are rarely asked to connect symbolic notation back to visual representations. In 2 experiments, we ask whether visual representations affect understanding of symbolic notation for adults who understand symbolic notation. In a conceptual fraction comparison task (e.g., Which is larger, 5 / a or 8 / a?), participants were given comparisons paired with accurate, helpful visual representations, misleading visual representations, or no visual representations. The results show that even college students perform significantly better when accurate visuals are provided over misleading or no visuals. Further, eye-tracking data suggest that these visual representations may affect performance even when only briefly looked at. Implications for theories of fraction understanding and education are discussed.

Studies of infants at risk for autism spectrum disorder (ASD) have proliferated, but few of these samples have been followed longer-term. We conducted a follow-up study, at age 5.5-9 years, of younger siblings of children with ASD (high-risk group, n = 79) or typical development (low-risk group, n = 60), originally recruited as infants. Children with ASD were excluded because of the focus on understanding the range of non-ASD outcomes among high-risk siblings. Using examiner ratings, parent ratings, and standardized assessments, we evaluated differences in clinical outcomes, psychopathology symptoms, autism symptoms, language skills, and nonverbal cognitive abilities. After adjusting for covariates, the high-risk group had increased odds of any clinically elevated/impaired score across measures relative to the low-risk group (43% vs. 12%, respectively). The high-risk group also had increased odds of examiner-rated Clinical Concerns (CC) outcomes (e.g., ADHD concerns, broader autism phenotype, speech-language difficulties, anxiety/mood problems, learning problems) relative to the low-risk group (38% vs. 13%, respectively). The high-risk group with CC outcomes had higher parent-reported psychopathology and autism symptoms, and lower directly-assessed language skills, than the Low-Risk Typically Developing (TD) and High-Risk TD groups, which did not differ. There were no differences in nonverbal cognitive skills. For some in the high-risk group, clinical concerns persisted from early childhood, whereas for others clinical concerns were first evident at school-age. Results suggest continued vulnerability in at least a subgroup of school-age children with a family history of ASD and suggest that this population may benefit from continued screening and monitoring into the school-age years. Autism Res 2016, 9: 632-642. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.