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Your search keyword '"Jo, Il-Joo"' showing total 114 results
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114 results on '"Jo, Il-Joo"'

7. Poria cocos Extract from Mushrooms Stimulates Aquaporin-3 via the PI3K/Akt/mTOR Signaling Pathway

Author

Park,Sung-Gu, Jo,Il-Joo, Park,Seol-A, Park,Min-Cheol, Mun,Yeun-Ja, Park,Sung-Gu, Jo,Il-Joo, Park,Seol-A, Park,Min-Cheol, and Mun,Yeun-Ja

Abstract

Sung-Gu Park,1,* Il-Joo Jo,2,* Seol-A Park,3 Min-Cheol Park,1 Yeun-Ja Mun4 1Department of Oriental Medical Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Wonkwang University, Iksan, South Korea; 2Central Stroke Center of Korean medicine, College of Korean Medicine, Wonkwang University, Iksan, South Korea; 3Department of Beauty Design Graduate School, Wonkwang University, Iksan, South Korea; 4Department of Anatomy, College of Korean Medicine, Wonkwang University, Iksan, South Korea*These authors contributed equally to this workCorrespondence: Yeun-Ja Mun, Department of Anatomy, College of Korean Medicine, Wonkwang University, Iksan, South Korea, Tel +82-63-850-6942, Email yjmun@wku.ac.krBackground: Poria cocos (PC), a fungus, has been used for more than 2000 years as a food and medicine in China. PC and its components have various pharmacological effects on the skin, including immunomodulatory activities, barrier function improvement, and anti-tumor effects. However, the effect of PC in aquaporin-3 (AQP3) expression, which is essential for epidermal water permeability barrier maintenance, was not reported.Methods: This study examined the mechanism through which the ethanol extract of the sclerotium of PC (EPC) promoted the expression of AQP3 in cultured human keratinocytes. Western blotting was used to investigate the expression of AQPs and the activation of phosphoinositide 3-kinase (PI3K)/Akt-related signaling molecules in HaCaT cells. Cells were treated with inhibitors of PI3K/Akt and mechanistic target of rapamycin (mTOR) prior to EPC treatment.Results: EPC promoted the expression of AQP3 in HaCaT cells without affecting AQP1 and AQP2 expression. Phosphorylated Akt levels were increased by EPC treatment, and the inhibition of PI3K by LY2940002 resulted in a reduction in EPC-induced AQP3 expression. Furthermore, EPC stimulated the phosphorylation of p70S6K and AktSer473, which are downstream targets of mTO

Published
2022

26. Berberine ameliorates lipopolysaccharide-induced inflammatory responses in mouse inner medullary collecting duct-3 cells by downregulation of NF-κB pathway.

Author

Kim, Dong-Gu, Choi, Ji-Won, Jo, Il-Joo, Kim, Myoung-Jin, Lee, Ho-Sub, Hong, Seung-Heon, Song, Ho-Joon, Bae, Gi-Sang, and Park, Sung-Joo

Subjects
BERBERINE, DOWNREGULATION, WESTERN immunoblotting, CELLS
Abstract

The major role of inner medullary collecting duct (IMCD) cells is to maintain water and sodium homeostasis. In addition to the major role, it also participates in the protection of renal and systemic inflammation. Although IMCD cells could take part in renal and systemic inflammation, investigations on renal inflammation in IMCD cells have rarely been reported. Although berberine (BBR) has been reported to show diverse pharmacological effects, its anti-inflammatory and protective effects on IMCD cells have not been studied. Therefore, in the present study, we examined the anti-inflammatory and protective effects of BBR in mouse IMCD-3 (mIMCD-3) cells against lipopolysaccharide (LPS). An MTT assay was carried out to investigate the toxicity of BBR on mIMCD-3 cells. Reverse transcription quantitative-PCR and western blotting were performed to analysis pro-inflammatory molecules and cytokines. Mechanisms of BBR were examined by western blotting and immunocytochemistry. According to previous studies, pro-inflammatory molecules, such as inducible nitric oxide synthase and cyclooxygenase-2, and pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6 and tumor necrosis factor-α are increased in LPS-exposed mIMCD-3 cells. However, the production of these pro-inflammatory molecules is significantly inhibited by treatment with BBR. In addition, BBR inhibited translocation of nuclear factor (NF)-κB p65 from the cytosol to the nucleus, and degradation of inhibitory κ-Bα in LPS-exposed mIMCD-3 cells. In conclusion, BBR could inhibit renal inflammatory responses via inhibition of NF-κB signaling and ultimately contribute to amelioration of renal injury during systemic inflammation. [ABSTRACT FROM AUTHOR]

Published
2020
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35. Opuntia humifusa Ameliorated Cerulein-Induced Acute Pancreatitis

Author

Choi, Sun Bok, primary, Bae, Gi-Sang, additional, Park, Kyoung-Chel, additional, Jo, Il-Joo, additional, Seo, Seung-Hee, additional, Song, Kyung, additional, Lee, Dong-Sung, additional, Oh, Hyuncheol, additional, Kim, Youn-Chul, additional, Kim, Jong-Jin, additional, Shin, Yong Kook, additional, Park, Jin-Han, additional, Seo, Min-Jun, additional, Song, Ho-Joon, additional, and Park, Sung-Joo, additional

Published
2014
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36. Beneficial Effects of Fractions ofNardostachys jatamansion Lipopolysaccharide-Induced Inflammatory Response

Author

Bae, Gi-Sang, primary, Heo, Kwang-Ho, additional, Choi, Sun Bok, additional, Jo, Il-Joo, additional, Kim, Dong-Goo, additional, Shin, Joon-Yeon, additional, Seo, Seung-Hee, additional, Park, Kyoung-Chel, additional, Lee, Dong-Sung, additional, Oh, Hyuncheol, additional, Kim, Youn-Chul, additional, Song, Ho-Joon, additional, Shin, Byung-Cheul, additional, and Park, Sung-Joo, additional

Published
2014
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38. The anti-inflammatory effect of Lithospermum Erythrorhizon on lipopolysaccharide - induced inflammatory response in RAW 264.7 cells

Author

Choi, Sun-Bok, primary, Bae, Gi-Sang, additional, Jo, Il-Joo, additional, Park, Kyoung-Chel, additional, Seo, Seung-Hee, additional, Kim, Dong-Goo, additional, Shin, Joon-Yeon, additional, Gwak, Tae-Sin, additional, Lee, Jung-Hyun, additional, Lee, Guem-San, additional, Park, Sung-Joo, additional, and Song, Ho-Joon, additional

Published
2013
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39. The Beneficial Effects of Nardostachys jatamansi Extract on Diet-Induced Severe Acute Pancreatitis

Author

Bae, Gi-Sang, primary, Park, Kyoung-Chel, additional, Koo, Bon Soon, additional, Jo, Il-Joo, additional, Choi, Sun Bok, additional, Lee, Dong-Sung, additional, Kim, Youn-Chul, additional, Kim, Jong-Jin, additional, Shin, Yong Kook, additional, Hong, Seung-Heon, additional, Kim, Tae-Hyeon, additional, Song, Ho-Joon, additional, and Park, Sung-Joo, additional

Published
2013
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41. Effects of OMC-2010 constituents on cytokine productions in mouse spleen cells

Author

Bae, Gi-Sang, primary, Kim, Hyun Sik, additional, Park, Kyoung-Chel, additional, Choi, Sun-Bok, additional, Jo, Il-Joo, additional, Lee, Chang-Hyuk, additional, Seo, Sang-Wan, additional, Kim, Jong-Jin, additional, Shin, Yong-Kook, additional, Kim, Min Sun, additional, Park, Kyu Hwan, additional, Song, Ho-Joon, additional, and Park, Sung-Joo, additional

Published
2012
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42. Effects of OMC-2010 extracts on cytokine productions in mouse spleen cells

Author

Bae, Gi-Sang, primary, Park, Kyoung-Chel, additional, Choi, Sun-Bok, additional, Jo, Il-Joo, additional, Seo, Sang-Wan, additional, Kim, Jong-Jin, additional, Shin, Yong-Kook, additional, Kim, Min-Sun, additional, Park, Kyu-Hwan, additional, Kim, Hyun-Sik, additional, Song, Ho-Joon, additional, and Park, Sung-Joo, additional

Published
2012
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47. Opuntia humifusaAmeliorated Cerulein-Induced Acute Pancreatitis

Author

Choi, Sun Bok, Bae, Gi-Sang, Park, Kyoung-Chel, Jo, Il-Joo, Seo, Seung-Hee, Song, Kyung, Lee, Dong-Sung, Oh, Hyuncheol, Kim, Youn-Chul, Kim, Jong-Jin, Shin, Yong Kook, Park, Jin-Han, Seo, Min-Jun, Song, Ho-Joon, and Park, Sung-Joo

Abstract

The aim of this study was to evaluate the effects of Opuntia humifusa(OH) on cerulein-induced acute pancreatitis (AP).

Published
2014
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49. Beneficial Effects of Fractions of Nardostachys jatamansi on Lipopolysaccharide-Induced Inflammatory Response.

Author

Bae GS, Heo KH, Choi SB, Jo IJ, Kim DG, Shin JY, Seo SH, Park KC, Lee DS, Oh H, Kim YC, Song HJ, Shin BC, and Park SJ

Abstract

It has been previously shown that Nardostachys jatamansi (NJ) exhibits anti-inflammatory properties against lipopolysaccharide (LPS) challenges. However, the potency of NJ constituents against LPS-induced inflammatory responses has not been examined. In this present study, we determined which NJ extract fractions exhibit inhibitory effects against LPS-induced inflammatory responses. Among the NJ fractions, NJ-1, NJ-3, NJ-4, and NJ-6 inhibited LPS-induced production of NO. The NJ-3, NJ-4, and NJ-6 fractions also inhibited the production of cytokines, such as IL-1 β , IL-6, and TNF- α . However, NJ-1, NJ-3, NJ-4, and NJ-6 showed differential inhibitory mechanisms against LPS-induced inflammatory responses. NJ-1, NJ-3, and NJ-4 inhibited LPS-induced activation of c-jun NH2-terminal kinase (JNK) and p38 but did not affect activation of extracellular signal-regulated kinase (ERK) or NF- κ B. On the other hand, NJ-6 inhibited activation of MAPKs and NF- κ B. In addition, in vivo experiments revealed that administration of NJ-1, NJ-3, NJ-4, and NJ-6 reduced LPS-induced endotoxin shock, with NJ-6 especially showing a marked protective effect. Taken together, these results provide the evidence for the potential of selective NJ fractions against LPS-induced inflammation. Thus, it will be advantageous to further isolate and determine single effective compounds from these potent fractions.

Published
2014
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50. Scolopendra subspinipes mutilans protected the cerulein-induced acute pancreatitis by inhibiting high-mobility group box protein-1.

Author

Jo IJ, Bae GS, Park KC, Choi SB, Jung WS, Jung SY, Cho JH, Choi MO, Song HJ, and Park SJ

Subjects
Acute Disease, Acute Lung Injury blood, Acute Lung Injury etiology, Acute Lung Injury prevention & control, Amylases blood, Animals, Cell Survival drug effects, Cells, Cultured, Ceruletide, Cytokines blood, Disease Models, Animal, Enzyme Activation, HMGB1 Protein metabolism, Inflammation Mediators blood, JNK Mitogen-Activated Protein Kinases metabolism, Lipase blood, Mice, Mice, Inbred C57BL, NF-kappa B metabolism, Pancreas metabolism, Pancreas pathology, Pancreatitis blood, Pancreatitis chemically induced, Pancreatitis genetics, Pancreatitis pathology, Signal Transduction drug effects, Time Factors, p38 Mitogen-Activated Protein Kinases metabolism, Anti-Inflammatory Agents pharmacology, Arthropod Venoms pharmacology, HMGB1 Protein antagonists & inhibitors, Pancreas drug effects, Pancreatitis prevention & control
Abstract

Aim: To evaluate the inhibitory effects of Scolopendra subspinipes mutilans (SSM) on cerulein-induced acute pancreatitis (AP) in a mouse model., Methods: SSM water extract (0.1, 0.5, or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of cerulein. Once AP developed, the stable cholecystokinin analogue, cerulein was injected hourly, over a 6 h period. Blood samples were taken 6 h later to determine serum amylase, lipase, and cytokine levels. The pancreas and lungs were rapidly removed for morphological examination, myeloperoxidase assay, and real-time reverse transcription polymerase chain reaction. To specify the role of SSM in pancreatitis, the pancreatic acinar cells were isolated using collagenase method. Then the cells were pre-treated with SSM, then stimulated with cerulein. The cell viability, cytokine productions and high-mobility group box protein-1 (HMGB-1) were measured. Furthermore, the regulating mechanisms of SSM action were evaluated., Results: The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury, as was shown by the reduction in pancreatic edema, neutrophil infiltration, vacuolization and necrosis. SSM treatment also reduced pancreatic weight/body weight ratio, serum amylase, lipase and cytokine levels, and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β. In addition, treatment with SSM inhibited HMGB-1 expression in the pancreas during AP. In accordance with in vivo data, SSM inhibited the cerulein-induced acinar cell death, cytokine, and HMGB-1 release. SSM also inhibited the activation of c-Jun NH2-terminal kinase, p38 and nuclear factor (NF)-κB., Conclusion: These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase, p38 and NF-κB.

Published
2013
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