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240 results on '"Jahnsen, Frode L"'

2. A Roadmap for the Human Gut Cell Atlas

Author

Zilbauer, Matthias, James, Kylie R., Kaur, Mandeep, Pott, Sebastian, Li, Zhixin, Burger, Albert, Thiagarajah, Jay R., Burclaff, Joseph, Jahnsen, Frode L., Perrone, Francesca, Ross, Alexander D., Matteoli, Gianluca, Stakenborg, Nathalie, Sujino, Tomohisa, Moor, Andreas, Bartolome-Casado, Raquel, Bækkevold, Espen S., Zhou, Ran, Xie, Bingqing, Lau, Ken S., Din, Shahida, Magness, Scott T., Yao, Qiuming, Beyaz, Semir, Arends, Mark, Denadai-Souza, Alexandre, Coburn, Lori A., Gaublomme, Jellert T., Baldock, Richard, Papatheodorou, Irene, Ordovas-Montanes, Jose, Boeckxstaens, Guy, Hupalowska, Anna, Teichmann, Sarah A., Regev, Aviv, Xavier, Ramnik J., Simmons, Alison, Snyder, Michael P., and Wilson, Keith T.

Published
2023
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6. Bin2cell reconstructs cells from high resolution Visium HD data.

Author

Polański, Krzysztof, Bartolomé-Casado, Raquel, Sarropoulos, Ioannis, Xu, Chuan, England, Nick, Jahnsen, Frode L, Teichmann, Sarah A, and Yayon, Nadav

Subjects
IMAGE segmentation, GENE expression, TRANSCRIPTOMES, COLORECTAL cancer, GENOMICS
Abstract

Summary Visium HD by 10X Genomics is the first commercially available platform capable of capturing full scale transcriptomic data paired with a reference morphology image from archived FFPE blocks at sub-cellular resolution. However, aggregation of capture regions to single cells poses challenges. Bin2cell reconstructs cells from the highest resolution data (2 μm bins) by leveraging morphology image segmentation and gene expression information. It is compatible with established Python single cell and spatial transcriptomics software, and operates efficiently in a matter of minutes without requiring a GPU. We demonstrate improvements in downstream analysis when using the reconstructed cells over default 8 μm bins on mouse brain and human colorectal cancer data. Availability and implementation Bin2cell is available at https://github.com/Teichlab/bin2cell , along with documentation and usage examples, and can be installed from pip. Probe design functionality is available at https://github.com/Teichlab/gene2probe. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease

Author

Divito, Sherrie J., Aasebo, Anders T., Matos, Tiago R., Hsieh, Pei-Chen, Collin, Matthew, Elco, Christopher P., O'Malley, John T., Baekkevold, Espen S., Reims, Henrik, Gedde-Dahl, Tobias, Hagerstrom, Michael, Hilaire, Jude, Lian, John W., Milford, Edgar L., Pinkus, Geraldine S., Ho, Vincent T., Soiffer, Robert J., Kim, Haesook T., Mihm, Martin C., Ritz, Jerome, Guleria, Indira, Cutler, Corey S., Clark, Rachael A., Jahnsen, Frode L., and Kupper, Thomas S.

Subjects
Thermo Fisher Scientific Inc., Medical research -- Health aspects, Skin -- Health aspects, Hematopoietic stem cell transplantation -- Health aspects, Stem cells -- Health aspects, Scientific equipment industry -- Health aspects, T cells -- Health aspects, Health care industry
Abstract

Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in hematopoietic stem cell transplantation (HSCT). Donor T cells are key mediators in pathogenesis, but a contribution from host T cells has not been explored, as conditioning regimens are believed to deplete host T cells. To evaluate a potential role for host T cells in GVHD, the origin of skin and blood T cells was assessed prospectively in patients after HSCT in the absence of GVHD. While blood contained primarily donor-derived T cells, most T cells in the skin were host derived. We next examined patient skin, colon, and blood during acute GVHD. Host T cells were present in all skin and colon acute GVHD specimens studied, yet were largely absent in blood. We observed acute skin GVHD in the presence of 100% host T cells. Analysis demonstrated that a subset of host T cells in peripheral tissues were proliferating ([Ki67.sup.+]) and producing the proinflammatory cytokines IFN-[gamma] and IL-17 in situ. Comparatively, the majority of antigen-presenting cells (APCs) in tissue in acute GVHD were donor derived, and donor-derived APCs were observed directly adjacent to host T cells. A humanized mouse model demonstrated that host skin-resident T cells could be activated by donor monocytes to generate a GVHD-like dermatitis. Thus, host tissue-resident T cells may play a previously unappreciated pathogenic role in acute GVHD., Introduction Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in hematopoietic stem cell transplantation (HSCT) (1-6). Current dogma holds that donor T cells, either transferred with or [...]

Published
2020
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9. Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease

Author

Høydahl, Lene Støkken, Richter, Lisa, Frick, Rahel, Snir, Omri, Gunnarsen, Kristin Støen, Landsverk, Ole J.B., Iversen, Rasmus, Jeliazkov, Jeliazko R., Gray, Jeffrey J., Bergseng, Elin, Foss, Stian, Qiao, Shuo-Wang, Lundin, Knut E.A., Jahnsen, Jørgen, Jahnsen, Frode L., Sandlie, Inger, Sollid, Ludvig M., and Løset, Geir Åge

Published
2019
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13. Separate Gut Plasma Cell Populations Produce Auto‐Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis

Author

Das, Saykat, primary, Stamnaes, Jorunn, additional, Kemppainen, Esko, additional, Hervonen, Kaisa, additional, Lundin, Knut E. A., additional, Parmar, Naveen, additional, Jahnsen, Frode L., additional, Jahnsen, Jørgen, additional, Lindfors, Katri, additional, Salmi, Teea, additional, Iversen, Rasmus, additional, and Sollid, Ludvig M., additional

Published
2023
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17. Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease

Author

Atlasy, N., Bujko, Anna, Baekkevold, Espen S., Brazda, Peter, Janssen-Megens, E.M., Lundin, Knut E.A., Jahnsen, Frode L., Stunnenberg, Hendrik G., Atlasy, N., Bujko, Anna, Baekkevold, Espen S., Brazda, Peter, Janssen-Megens, E.M., Lundin, Knut E.A., Jahnsen, Frode L., and Stunnenberg, Hendrik G.

Abstract

Contains fulltext : 253569.pdf (Publisher’s version ) (Open Access)

Published
2022

19. Allogeneic Bone Marrow Transplantation for Patients with Treatment-Refractory Crohn's Disease

Author

McDonald, George B. Bernard, primary, Landsverk, Ole J.B., additional, McGovern, Dermot, additional, Aasebø, Anders, additional, Paulsen, Vemund, additional, Haritunians, Talin, additional, Reims, Henrik M., additional, McLaughlin, Bernadette M., additional, Zisman, Timothy, additional, Li, Dalin, additional, Elholm, Elisabeth T.M.M., additional, Jahnsen, Frode L., additional, Georges, George E., additional, and Gedde-Dahl, Tobias, additional

Published
2022
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26. Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ

Author

Sikkeland, Liv I.B., primary, Qiao, Shuo-Wang, additional, Ueland, Thor, additional, Myrdal, Ole, additional, Wyrożemski, Łukasz, additional, Aukrust, Pål, additional, Jahnsen, Frode L., additional, Sjåheim, Tone, additional, Kongerud, Johny, additional, Molberg, Øyvind, additional, Lund, May Brit, additional, and Bækkevold, Espen S., additional

Published
2020
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27. The human small intestine contains two subsets of regulatory Foxp3+ CD4+ T cells with very different life span and functional properties

Author

Chauhan, Sudhir Kumar, primary, Casado, Raquel Bartolomé, additional, Landsverk, Ole J.B., additional, Johannessen, Hanna, additional, Phung, Danh, additional, Sætre, Frank, additional, Jahnsen, Jørgen, additional, Horneland, Rune, additional, Yaqub, Sheraz, additional, Aandahl, Einar Martin, additional, Lundin, Knut E.A., additional, Bækkevold, Espen S., additional, and Jahnsen, Frode L., additional

Published
2020
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28. CD4+ T cells persist for years in the human small intestine and mediate robust TH1 immunity

Author

Casado, Raquel Bartolomé, primary, Landsverk, Ole J.B., additional, Chauhan, Sudhir Kumar, additional, Sætre, Frank, additional, Hagen, Kjersti Thorvaldsen, additional, Yaqub, Sheraz, additional, Øyen, Ole, additional, Horneland, Rune, additional, Aandahl, Einar Martin, additional, Aabakken, Lars, additional, Bækkevold, Espen S., additional, and Jahnsen, Frode L., additional

Published
2019
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29. Characterisation of the endocrine pancreas in type 1 diabetes : islet size is maintained but islet number is markedly reduced

Author

Seiron, Peter, Wiberg, Anna, Kuric, Enida, Krogvold, Lars, Jahnsen, Frode L., Dahl-Jorgensen, Knut, Skog, Oskar, Korsgren, Olle, Seiron, Peter, Wiberg, Anna, Kuric, Enida, Krogvold, Lars, Jahnsen, Frode L., Dahl-Jorgensen, Knut, Skog, Oskar, and Korsgren, Olle

Abstract

Insulin deficiency in type 1 diabetes (T1D) is generally considered a consequence of immune-mediated specific beta-cell loss. Since healthy pancreatic islets consist of similar to 65% beta cells, this would lead to reduced islet size, while the number of islets per pancreas volume (islet density) would not be affected. In this study, we compared the islet density, size, and size distribution in biopsies from subjects with recent-onset or long-standing T1D, with that in matched non-diabetic subjects. The results presented show preserved islet size and islet size distribution, but a marked reduction in islet density in subjects with recent onset T1D compared with non-diabetic subjects. No further reduction in islet density occurred with increased disease duration. Insulin-negative islets in T1D subjects were dominated by glucagon-positive cells that often had lost the alpha-cell transcription factor ARX while instead expressing PDX1, normally only expressed in beta cells within the islets. Based on our findings, we propose that failure to establish a sufficient islet number to reach the beta-cell mass needed to cope with episodes of increased insulin demand contributes to T1D susceptibility. Exhaustion induced by relative lack of beta cells could then potentially drive beta-cell dedifferentiation to alpha-cells, explaining the preserved islet size observed in T1D compared to controls., Knut Dahl‐Jørgensen, Oskar Skog and Olle Korsgren share senior authorship. Peter Seiron and Anna Wiberg contributed equally to this work.

Published
2019
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33. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

Papadopoulos Nikolaos G, Agache Ioana, Bavbek Sevim, Bilo Beatrice M, Braido Fulvio, Cardona Victoria, Custovic Adnan, deMonchy Jan, Demoly Pascal, Eigenmann Philippe, Gayraud Jacques, Grattan Clive, Heffler Enrico, Hellings Peter W, Jutel Marek, Knol Edward, Lötvall Jan, Muraro Antonella, Poulsen Lars K, Roberts Graham, Schmid-Grendelmeier Peter, Skevaki Chrysanthi, Triggiani Massimo, vanRee Ronald, Werfel Thomas, Flood Breda, Palkonen Susanna, Savli Roberta, Allegri Pia, Annesi-Maesano Isabella, Annunziato Francesco, Antolin-Amerigo Dario, Apfelbacher Christian, Blanca Miguel, Bogacka Ewa, Bonadonna Patrizia, Bonini Matteo, Boyman Onur, Brockow Knut, Burney Peter, Buters Jeroen, Butiene Indre, Calderon Moises, Cardell Lars, Caubet Jean-Christoph, Celenk Sevcan, Cichocka-Jarosz Ewa, Cingi Cemal, Couto Mariana, deJong Nicolette, Del Giacco Stefano, Douladiris Nikolaos, Fassio Filippo, Fauquert Jean-Luc, Fernandez Javier, Rivas Montserrat, Ferrer Marta, Flohr Carsten, Gardner James, Genuneit Jon, Gevaert Philippe, Groblewska Anna, Hamelmann Eckard, Hoffmann Hans, Hoffmann-Sommergruber Karin, Hovhannisyan Lilit, Hox Valérie, Jahnsen Frode L, Kalayci Ömer, Kalpaklioglu Ayse, Kleine-Tebbe Jörg, Konstantinou George, Kurowski Marcin, Lau Susanne, Lauener Roger, Lauerma Antti, Logan Kirsty, Magnan Antoine, Makowska Joanna, Makrinioti Heidi, Mangina Paraskevi, Manole Felicia, Mari Adriano, Mazon Angel, Mills Clare, Mingomataj ErvinÇ, Niggemann Bodo, Nilsson Gunnar, Ollert Markus, O'Mahony Liam, O'Neil Serena, Pala Gianni, Papi Alberto, Passalacqua Gianni, Perkin Michael, Pfaar Oliver, Pitsios Constantinos, Quirce Santiago, Raap Ulrike, Raulf-Heimsoth Monika, Rhyner Claudio, Robson-Ansley Paula, Alves Rodrigo, Roje Zeljka, Rondon Carmen, Rudzeviciene Odilija, Ruëff Franziska, Rukhadze Maia, Rumi Gabriele, Sackesen Cansin, Santos Alexandra F, Santucci Annalisa, Scharf Christian, Schmidt-Weber Carsten, Schnyder Benno, Schwarze Jürgen, Senna Gianenrico, Sergejeva Svetlana, Seys Sven, Siracusa Andrea, Skypala Isabel, Sokolowska Milena, Spertini Francois, Spiewak Radoslaw, Sprikkelman Aline, Sturm Gunter, Swoboda Ines, Terreehorst Ingrid, Toskala Elina, Traidl-Hoffmann Claudia, Venter Carina, Vlieg-Boerstra Berber, Whitacker Paul, Worm Margitta, Xepapadaki Paraskevi, and Akdis Cezmi A

Subjects
Allergy, Allergic diseases, Policy, Research needs, Research funding, Europe, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients’ Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients’ organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

Published
2012
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36. Resident memory CD8 T cells persist for years in human small intestine

Author

Bartolomé-Casado, Raquel, primary, Landsverk, Ole J.B., additional, Chauhan, Sudhir Kumar, additional, Richter, Lisa, additional, Phung, Danh, additional, Greiff, Victor, additional, Risnes, Louise F., additional, Yao, Ying, additional, Neumann, Ralf S., additional, Yaqub, Sheraz, additional, Øyen, Ole, additional, Horneland, Rune, additional, Aandahl, Einar Martin, additional, Paulsen, Vemund, additional, Sollid, Ludvig M., additional, Qiao, Shuo-Wang, additional, Baekkevold, Espen S., additional, and Jahnsen, Frode L., additional

Published
2019
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37. Resident memory CD8 T cells persist for years in human small intestine

Author

Bartolomé Casado, Raquel, primary, Landsverk, Ole J.B., additional, Chauhan, Sudhir Kumar, additional, Richter, Lisa, additional, Phung, Dang, additional, Greiff, Victor, additional, Risnes, Louise Fremgaard, additional, Yao, Ying, additional, Neumann, Ralf Stefan, additional, Yaqub, Sheraz, additional, Øyen, Ole, additional, Horneland, Rune, additional, Aandahl, Einar Martin, additional, Paulsen, Vemund, additional, Sollid, Ludvig M., additional, Qiao, Shuo-Wang, additional, Bækkevold, Espen S., additional, and Jahnsen, Frode L., additional

Published
2019
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41. Transcriptional and functional profiling defines human small intestinal macrophage subsets

Author

Bujko, Anna, Atlasy, N., Landsverk, Ole J.B., Richter, L., Yaqub, Sheraz, Horneland, Rune, Stunnenberg, Hendrik G., Baekkevold, Espen S., Jahnsen, Frode L., Bujko, Anna, Atlasy, N., Landsverk, Ole J.B., Richter, L., Yaqub, Sheraz, Horneland, Rune, Stunnenberg, Hendrik G., Baekkevold, Espen S., and Jahnsen, Frode L.

Abstract

Contains fulltext : 189872.pdf (publisher's version ) (Open Access)

Published
2018

42. Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow's milk allergy in mice

Author

Afd Pharmacology, Pharmacology, van Bergenhenegouwen, Jeroen, Braber, Saskia, Loonstra, Reinilde, Buurman, Nicole, Rutten, Lieke, Knipping, Karen, Savelkoul, Paul J, Harthoorn, Lucien F, Jahnsen, Frode L, Garssen, Johan, Hartog, Anita, Afd Pharmacology, Pharmacology, van Bergenhenegouwen, Jeroen, Braber, Saskia, Loonstra, Reinilde, Buurman, Nicole, Rutten, Lieke, Knipping, Karen, Savelkoul, Paul J, Harthoorn, Lucien F, Jahnsen, Frode L, Garssen, Johan, and Hartog, Anita

Published
2018

43. Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow's milk allergy in mice

Author

Pharmacology, Afd Pharmacology, van Bergenhenegouwen, Jeroen, Braber, Saskia, Loonstra, Reinilde, Buurman, Nicole, Rutten, Lieke, Knipping, Karen, Savelkoul, Paul J, Harthoorn, Lucien F, Jahnsen, Frode L, Garssen, Johan, Hartog, Anita, Pharmacology, Afd Pharmacology, van Bergenhenegouwen, Jeroen, Braber, Saskia, Loonstra, Reinilde, Buurman, Nicole, Rutten, Lieke, Knipping, Karen, Savelkoul, Paul J, Harthoorn, Lucien F, Jahnsen, Frode L, Garssen, Johan, and Hartog, Anita

Published
2018

45. Cover Image

Author

Eguíluz‐Gracia, Ibon, primary, Malmstrom, Kristiina, additional, Dheyauldeen, Sinan Ahmed, additional, Lohi, Jouko, additional, Sajantila, Antti, additional, Aaløkken, Ragnhild, additional, Sundaram, Arvind Y. M., additional, Gilfillan, Gregor D., additional, Makela, Mika, additional, Baekkevold, Espen S., additional, and Jahnsen, Frode L., additional

Published
2018
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46. Monocytes accumulate in the airways of children with fatal asthma

Author

Eguíluz‐Gracia, Ibon, primary, Malmstrom, Kristiina, additional, Dheyauldeen, Sinan Ahmed, additional, Lohi, Jouko, additional, Sajantila, Antti, additional, Aaløkken, Ragnhild, additional, Sundaram, Arvind Y. M., additional, Gilfillan, Gregor D., additional, Makela, Mika, additional, Baekkevold, Espen S., additional, and Jahnsen, Frode L., additional

Published
2018
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48. Transcriptional and functional profiling defines human small intestinal macrophage subsets

Author

Bujko, Anna, primary, Atlasy, Nader, additional, Landsverk, Ole J.B., additional, Richter, Lisa, additional, Yaqub, Sheraz, additional, Horneland, Rune, additional, Øyen, Ole, additional, Aandahl, Einar Martin, additional, Aabakken, Lars, additional, Stunnenberg, Hendrik G., additional, Bækkevold, Espen S., additional, and Jahnsen, Frode L., additional

Published
2017
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50. CD4+T cells persist for years in the human small intestine and display a TH1 cytokine profile

Author

Bartolomé-Casado, Raquel, Landsverk, Ole J. B., Chauhan, Sudhir Kumar, Sætre, Frank, Hagen, Kjersti Thorvaldsen, Yaqub, Sheraz, Øyen, Ole, Horneland, Rune, Aandahl, Einar Martin, Aabakken, Lars, Bækkevold, Espen S., and Jahnsen, Frode L.

Abstract

Studies in mice and humans have shown that CD8+T cell immunosurveillance in non-lymphoid tissues is dominated by resident populations. Whether CD4+T cells use the same strategies to survey peripheral tissues is less clear. Here, examining the turnover of CD4+T cells in transplanted duodenum in humans, we demonstrate that the majority of CD4+T cells were still donor-derived one year after transplantation. In contrast to memory CD4+T cells in peripheral blood, intestinal CD4+TRMcells expressed CD69 and CD161, but only a minor fraction expressed CD103. Functionally, intestinal CD4+TRMcells were very potent cytokine producers; the vast majority being polyfunctional TH1 cells, whereas a minor fraction produced IL-17. Interestingly, a fraction of intestinal CD4+T cells produced granzyme-B and perforin after activation. Together, we show that the intestinal CD4+T-cell compartment is dominated by resident populations that survive for more than 1 year. This finding is of high relevance for the development of oral vaccines and therapies for diseases in the gut.

Published
2021
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