68 results on '"J. R. Bartlett"'
Search Results
2. Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia.
- Author
-
Michael J J Chu, Anthony J R Hickey, Sherry Tagaloa, Linda Zhang, Anna J Dare, Julia R MacDonald, Mee-Ling Yeong, Adam S J R Bartlett, and Anthony R J Phillips
- Subjects
Medicine ,Science - Abstract
BACKGROUND: Hepatic steatosis is a major risk factor for graft failure in liver transplantation. Hepatic steatosis shows a greater negative influence on graft function following prolonged cold ischaemia. As the impact of steatosis on hepatocyte metabolism during extended cold ischaemia is not well-described, we compared markers of metabolic capacity and mitochondrial function in steatotic and lean livers following clinically relevant durations of cold preservation. METHODS: Livers from 10-week old leptin-deficient obese (ob/ob, n = 9) and lean C57 mice (n = 9) were preserved in ice-cold University of Wisconsin solution. Liver mitochondrial function was then assessed using high resolution respirometry after 1.5, 3, 5, 8, 12, 16 and 24 hours of storage. Metabolic marker enzymes for anaerobiosis and mitochondrial mass were also measured in conjunction with non-bicarbonate tissue pH buffering capacity. RESULTS: Ob/ob and lean mice livers showed severe (>60%) macrovesicular and mild (
- Published
- 2014
- Full Text
- View/download PDF
3. Hepatic mitochondrial function analysis using needle liver biopsy samples.
- Author
-
Michael J J Chu, Anthony R J Phillips, Alexander W G Hosking, Julia R MacDonald, Adam S J R Bartlett, and Anthony J R Hickey
- Subjects
Medicine ,Science - Abstract
Backgrounds and aimCurrent assessment of pre-operative liver function relies upon biochemical blood tests and histology but these only indirectly measure liver function. Mitochondrial function (MF) analysis allows direct measurement of cellular metabolic function and may provide an additional index of hepatic health. Conventional MF analysis requires substantial tissue samples (>100 mg) obtained at open surgery. Here we report a method to assess MF using MethodsAn 18G Bard® Max-core® biopsy instrument was used to collect samples. The optimal Tru-cut® sample weight, stability in ice-cold University of Wisconsin solution, reproducibility and protocol utility was initially evaluated in Wistar rat livers then confirmed in human samples. MF was measured in saponin-permeabilized samples using high-resolution respirometry.ResultsThe average mass of a single rat and human liver Tru-cut® biopsy was 5.60±0.30 and 5.16±0.15 mg, respectively (mean; standard error of mean). Two milligram of sample was found the lowest feasible mass for the MF assay. Tissue MF declined after 1 hour of cold storage. Six replicate measurements within rats and humans (n = 6 each) showed low coefficient of variation (ConclusionConsistent measurement of liver MF and detection of derangement in a disease state was successfully demonstrated using less than half the tissue from a single Tru-cut® biopsy. Using this technique outpatient assessment of liver MF is now feasible, providing a new assay for the evaluation of hepatic function.
- Published
- 2013
- Full Text
- View/download PDF
4. Texture and acceptability of goat meat frankfurters processed with 3 different sources of fat
- Author
-
Christy L. Bratcher, Norma L Dawkins, Chris R. Kerth, J R Bartlett, and S.G. Solaiman
- Subjects
Male ,Random allocation ,Chemistry ,Goats ,General Medicine ,Sensory analysis ,Fats ,Meat Products ,Random Allocation ,Taste ,Chewiness ,Texture profile analysis ,Genetics ,Animals ,Humans ,Female ,Animal Science and Zoology ,Texture (crystalline) ,Food science ,Least-Squares Analysis ,Flavor ,Food Science - Abstract
The objective of this research was to evaluate the texture and consumer acceptability of goat meat frankfurter formulations with no added fat (NAF), beef fat (BF), or canola oil (CO). Consumer sensory evaluation, fat, and moisture and texture profile analyses were performed on goat meat frankfurters produced with the fat sources BF, CO, and NAF. For sensory evaluations, NAF was less tender (P = 0.007; 4.90 vs. 4.11 and 4.35 for BF and CO, respectively) and the flavor was liked less (P = 0.004; 4.59 vs. 3.83 and 4.30 for BF and CO, respectively); BF was scored as the juiciest (P = 0.003; 3.86 vs. 4.49 and 4.58 for CO and NAF, respectively); and CO had the least amount of flavor (P = 0.029; 3.65 vs. 3.12 and 3.10 for BF and NAF, respectively). Moisture was least (P < 0.001) in CO (46.59%), followed by BF (48.57%) and NAF (55.80%). The amount of fat was not different (P = 0.761) in BF (24.36%) or CO (24.43%) but was less (P < 0.001) in NAF (9.06%), as expected. The NAF had the most protein (P < 0.001; 34.14%), followed by CO (27.98%) and BF (26.07%). For texture profile analyses, NAF had the least hardness value (P = 0.008; 3.92 vs. 4.48 and 4.40 for BF and CO, respectively) and least chewiness value (P = 0.026; 2.89 vs. 3.39 and 3.29 for BF and CO, respectively). Beef fat and CO were not different for hardness (P = 0.596) or chewiness (P = 0.530). No differences were observed in springiness (P = 0.954) or resilience (P = 0.561). The sensory panelists tended to prefer BF for overall acceptability. Results from these data revealed that value-added goat meat products received acceptable sensory scores; therefore, continued research and development will greatly expand the knowledge of goat meat and increase the acceptance of value-added products.
- Published
- 2011
5. Review: What did the Biblical Writers Know and When Did They Know it? What Archaeology Can Tell Us about the Reality of Ancient Israel
- Author
-
J. R. Bartlett
- Subjects
Literature ,History ,business.industry ,Religious studies ,business ,Archaeology ,Classics - Published
- 2002
6. Improved Breast Cytology Results with Near Patient FNA Diagnosis
- Author
-
Adam St. J. R. Bartlett, Ian Campbell, Ann Darlington, James Hamill, and Frederick George Mayall
- Subjects
Adult ,medicine.medical_specialty ,Histology ,Mammary gland ,Breast Neoplasms ,Sensitivity and Specificity ,Pathology and Forensic Medicine ,Predictive Value of Tests ,Cytology ,medicine ,Humans ,skin and connective tissue diseases ,Breast cytology ,medicine.diagnostic_test ,business.industry ,Biopsy, Needle ,Breast lumps ,General Medicine ,Middle Aged ,Surgery ,Fine-needle aspiration ,medicine.anatomical_structure ,Cytopathology ,Radiology ,medicine.symptom ,business - Abstract
OBJECTIVE: To examine the impact of a cytopathologist using near patient fine needle aspiration diagnosis (NPFD) for breast diagnosis. STUDY DESIGN: The cytology results of all palpable solid breast lesions undergoing fine needle aspiration (FNA) during a two-year period were prospectively audited and categorized as definitely benign or malignant (definite), probably benign, indeterminate or suspicious (indefinite) or unsatisfactory. The final diagnosis (benign or malignant) was determined from a review of patients' charts and a survey of patients' family physicians. Aspirates were performed by surgical staff and reported either later (non-NPFD) or by NPFD. RESULTS: Of 720 FNAs, 230 were by NPFD and 490 by non-NPFD. NPFD was associated with a significantly greater proportion of definite reports (91.9% versus 82.4%). NPFD of discrete breast lumps was associated with higher specificity (89.1% versus 67.5%) and a lower unsatisfactory rate (9.4% versus 19.6%) than non-NPFD. NPFD did not improve the unsatisfactory rate of FNAs from diffuse breast thickenings. CONCLUSION: FNA by a dedicated specialist and immediate reporting should be an integral part of a breast diagnostic service.
- Published
- 2002
7. REVIEWS
- Author
-
J. R. BARTLETT
- Subjects
Religious studies - Published
- 2001
8. Performance and adipose cellularity of female progeny of White Plymouth Rock dams and commercial broiler breeder sires
- Author
-
S. L. Louis, J. R. Bartlett, Samuel N. Nahashon, and C. O. Briles
- Subjects
business.industry ,Broiler ,Adipose tissue ,Biology ,Broiler breeder ,Body weight ,Crossbreed ,Biotechnology ,Carcass weight ,Animal science ,medicine ,Abdominal fat ,Animal Science and Zoology ,medicine.symptom ,business ,Weight gain ,Food Science - Published
- 2000
9. Depression: a role for neurosurgery?
- Author
-
G. S. Malhi and J. R. Bartlett
- Subjects
Male ,Depressive Disorder ,Obsessive-Compulsive Disorder ,medicine.medical_specialty ,business.industry ,Neuropsychology ,General Medicine ,Frontal Lobe ,Psychosurgery ,Stereotaxic Techniques ,Mood ,Neuroimaging ,Stereotaxic technique ,medicine ,Humans ,Female ,Surgery ,Neurology (clinical) ,Neurosurgery ,Prefrontal cortex ,business ,Psychiatry ,Neuroscience ,Depression (differential diagnoses) - Abstract
After providing an overview of depression this article briefly reviews the development of psychosurgery and outlines the current procedures in use world wide. Stereotactic subcaudate tractotomy (SST) is described in particular detail, and the rationale for its use in the treatment of resistant depression is then discussed by considering the findings of neuropsychological, neurophysiological and neuroimaging studies. The emerging evidence suggests that the prefrontal cortex subserves an essential function in emotion and that disruption of its connections modifies mood.
- Published
- 2000
10. The Maccabean Martyrs as Saviours of the Jewish People. A Study of 2 and 4 Maccabees. By Jan van Henten. Pp. xi + 346. (Supplements to the Journal for the Study of Judaism, 57.) Leiden: Brill, 1997. ISBN 90 04 10976 5. Gld. 195/$115
- Author
-
J. R. Bartlett
- Subjects
History ,biology ,Judaism ,Religious studies ,Brill ,Theology ,biology.organism_classification - Published
- 1999
11. Spinal meningiomas: a 20-year review
- Author
-
R. W. Gullan, Andrew T. King, M. M. Sharr, and J. R. Bartlett
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Tumor resection ,Central nervous system disease ,Meningioma ,Meningeal Neoplasms ,medicine ,Humans ,Aged ,Aged, 80 and over ,Postoperative Care ,Movement Disorders ,Surgical approach ,business.industry ,Spinal Meningiomas ,Urinary Bladder Diseases ,Laminectomy ,Diathermy ,General Medicine ,Middle Aged ,medicine.disease ,Spinal cord ,Magnetic Resonance Imaging ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Female ,Neurology (clinical) ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
The long-term outcome of 78 patients with spinal meningiomas operated on over 20 years at a single neurosurgical unit was analysed. Age, sex and tumour location were similar to those reported by others. Overall, 95% of our patents were independently mobile postoperatively, despite 25% of the group being unable to walk before operation, including four paraplegic patients. Only two tumours were entirely extradural, and a further two were both intra- and extradural. In all cases, tumour exposure was by posterior laminectomy, without recourse to more complex approaches. Complete tumour resection was achieved in 77 (98%) of cases. The dural attachment was excised in 20 cases and diathermy was applied in 58. There was one recurrence, 14 years after the original surgery. Complex and technically challenging surgical approaches are unnecessary to obtain complete removal even for anteriorly placed tumours. Excision of the dural base would seem unnecessary to attain a low recurrence rate.
- Published
- 1998
12. Counter-ion adsorption and homogeneity of TiO2/ZrO2 nanoparticles from SANS contrast variation
- Author
-
J. R. Bartlett, D. Gazeau, Th. Zemb, and J. L. Woolfrey
- Subjects
Colloid and Surface Chemistry ,Polymers and Plastics ,Organic Chemistry ,Materials Chemistry ,Physical and Theoretical Chemistry - Published
- 1997
13. Reviews
- Author
-
J. R. Bartlett
- Subjects
Archeology ,History - Published
- 1997
14. Additive effect of pretransplant obesity, diabetes, and cardiovascular risk factors on outcomes after liver transplantation
- Author
-
Anna J, Dare, Lindsay D, Plank, Anthony R J, Phillips, Edward J, Gane, Barry, Harrison, David, Orr, Yannan, Jiang, and Adam S J R, Bartlett
- Subjects
Adult ,Male ,Length of Stay ,Middle Aged ,Fibrosis ,Hepatitis C ,Body Mass Index ,Liver Transplantation ,Diabetes Complications ,End Stage Liver Disease ,Young Adult ,Treatment Outcome ,Cardiovascular Diseases ,Risk Factors ,Humans ,Female ,Obesity ,Aged ,New Zealand ,Retrospective Studies - Abstract
The effects of pretransplant obesity, diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HTN) on outcomes after liver transplantation (LT) are controversial. Questions have also been raised about the appropriateness of the body mass index (BMI) for assessing obesity in patients with end-stage liver disease. Both issues have implications for organ allocation in LT. To address these questions, we undertook a cohort study of 202 consecutive patients (2000-2010) undergoing LT at a national center in New Zealand. BMI and body fat percentage (%BF) values (dual-energy X-ray absorptiometry) were measured before transplantation, and the methods were compared. The influence of pretransplant risk variables (including obesity, DM, CAD, and HTN) on the 30-day postoperative event rate, length of hospital stay, and survival were analyzed. There was agreement between the calculated BMI and the measured %BF for 86.0% of the study population (κ coefficient = 0.73, 95% confidence interval = 0.61-0.85), and this was maintained across increasing Model for End-Stage Liver Disease scores. Obesity was an independent risk factor for the postoperative event rate [count ratio (CR) = 1.03, P0.001], as was DM (CR = 1.4, P0.001). Obesity with concomitant DM was the strongest predictor of the postoperative event rate (CR = 1.75, P0.001) and a longer hospital stay (5.81 days, P0.01). Independent metabolic risk factors had no effect on 30-day, 1-year, or 5-year patient survival. In conclusion, BMI is an adequate tool for assessing obesity-associated risk in LT. Early post-LT morbidity is highest for patients with concomitant obesity and DM, although these factors do not appear to influence recipient survival.
- Published
- 2013
15. Linkage Analysis of Endogenous Viral Element 1, Blue Eggshell, and Pea Comb Loci in Chickens
- Author
-
J. R. Bartlett, C. P. Jones, E. J. Smith, and L. Crittenden
- Subjects
Genetics ,Genetic linkage ,Biology ,Eggshell ,Molecular Biology ,Genetics (clinical) ,Biotechnology ,Endogenous viral element - Published
- 1996
16. Prediction of outcome in severe head injury based on recognition of sleep related activity in the polygraphic electroencephalogram
- Author
-
J R Bartlett and B M Evans
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Polysomnography ,Poison control ,Brain damage ,Electroencephalography ,Audiology ,Arousal ,Predictive Value of Tests ,medicine ,Humans ,Disabled Persons ,Glasgow Coma Scale ,Child ,Aged ,medicine.diagnostic_test ,Head injury ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Surgery ,Psychiatry and Mental health ,Alertness ,Brain Injuries ,Child, Preschool ,Female ,Neurology (clinical) ,medicine.symptom ,Sleep ,Psychology ,Research Article ,Follow-Up Studies - Abstract
This study shows that the continuing presence of activity similar to normal sleep in the EEG in conjunction with the EEG polygraph (EEGP) can be used to determine the severity of brain damage after head injury. Recordings were taken within seven days of head injury from 154 unselected patients after resuscitation and emergency surgery. Sixteen patients with ongoing seizures were excluded. In the remaining 138 patients the presence of activity in the EEG, EEGP, or both, which can also be recognised in normal alertness and sleep, was noted. Particular attention was paid to the presence or absence of arousal related phasic activity involving EEG, motor, and autonomic changes. The traces were allocated to one of five groups: group 1, wakeful traces with normal alpha in at least one hemisphere; group 2, sleep-like traces with K complexes responsive to stimulation; group 3, traces with phasic activity related to abnormal spontaneous arousal including EEG changes; group 4, traces with abnormal spontaneous arousal activity without EEG changes; group 5, traces with no spontaneous arousal activity. The mean follow up was 21.5 months. Groups 2 and 3 were significantly associated with a good outcome and group 5 with death or a vegetative state. Comparison between the EEG/EEGP findings and the Glasgow coma scale at the time of the recording showed the EEG/EEGP to be the better predictor of outcome, particularly for individual patients.
- Published
- 1995
17. Edom (Place)
- Author
-
J. R. Bartlett and Burton MacDonald
- Published
- 1992
18. The Flourishing of Jewish Sects in the Maccabean Era: An Interpretation. By Albert I. Baumgarten. Pp. xiii + 240. (Supplements to the Journal for the Study of Judaism, 55.) Leiden: Brill, 1997. ISBN 90 04 10751 7. N.p
- Author
-
J. R. Bartlett
- Subjects
History ,biology ,Flourishing ,Judaism ,Interpretation (philosophy) ,Religious studies ,Brill ,Theology ,biology.organism_classification - Published
- 1999
19. Photovoltaic Coatings
- Author
-
C. J. Barbé and J. R. Bartlett
- Published
- 2004
20. 3 Maccabees. By N. CLAYTON CROY
- Author
-
J. R. Bartlett
- Subjects
Religious studies - Published
- 2005
21. Psychosurgery: stereotactic subcaudate tractomy. An indispensable treatment
- Author
-
A. S. Hale, J R Bartlett, Hodgkiss Ad, Andrea Malizia, Amanda Poynton, and P K Bridges
- Subjects
Adult ,Male ,medicine.medical_specialty ,MEDLINE ,Stereotaxic surgery ,Suicide rates ,law.invention ,Stereotaxic Techniques ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,030212 general & internal medicine ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Brain Mapping ,business.industry ,Mental Disorders ,Middle Aged ,030227 psychiatry ,Surgery ,Psychosurgery ,Psychiatry and Mental health ,Treatment Outcome ,Female ,Caudate Nucleus ,business - Abstract
BackgroundStereotactic subcaudate tractotomy (SST) is the only type of psychosurgery performed at the Geoffrey Knight Unit, London, where nearly 1300 operations have been done since 1961. Statistically reliable data are not available to prove the effectiveness of SST. A detailed statement about contemporary psychosurgery is given.MethodRelevant publications from the Unit and via Medline are discussed. The outcome figures are reviewed. The outcome is assessed at the Unit in global and clinical terms, associated with results of self-completed questionnaires.ResultsST allows 40–60% of patients to live normal or near-normal lives, perhaps with continuation of medication. A reduction in suicide rate to 1% postoperatively, from 15% in cases of uncontrolled affective disorders is seen.ConclusionAs a treatment of last resort, no controlled trial against a comparable treatment is possible. It appears reasonable to offer SST to patients with suicidal and deluded depression or with frequently swinging moods, not responding to other treatments.
- Published
- 1994
22. Cerebral Effects of Stereotactic Subcaudate Tractotomy
- Author
-
J R Bartlett, Andrea Malizia, P K Bridges, J. B. Bingham, and M. G. Graves
- Subjects
Lesion ,Quadrant (abdomen) ,Electroconvulsive therapy ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,medicine ,Magnetic resonance imaging ,medicine.symptom ,Time optimal ,Nuclear medicine ,business ,Treatment resistant - Abstract
The psychosurgical operation of stereotactic subcaudate tractotomy (SST) is performed for patients who have treatment resistant affective illness refractory to electroconvulsive therapy (ECT) and vigorous pharmacotherapy (Bartlett et al. 1981). The operation consists of placing ten yttrium-90 rods, 7mm long by 1 mm in diameter, in the ventroposterior quadrant of the frontal lobes. They are placed stereotactically using a Macaul frame by taking repeat anteroposterior and lateral air ventriculograms and hence calculating the siting. Some 60% of patients get well either on or off medication; the response is slow, requiring 3–12 months. Some 20 patients from the whole UK are operated on every year. There are no major adverse personality changes (Goktepe et al. 1975). This pilot study was undertaken to determine the precise siting of the lesion, the effects of the operation on the brain at various postoperative times and the optimal time intervals for magnetic resonance imaging (MRI) of the patients postoperatively.
- Published
- 1993
23. Antemortem measurements of neurotransmission: possible implications for pharmacotherapy of Alzheimer's disease and depression
- Author
-
J R Bartlett, Andrew W. Procter, D. J. Thomas, M. N. Pangalos, P K Bridges, Andrea Malizia, Paul T. Francis, P H Stephens, David M. Bowen, and David Neary
- Subjects
Adult ,Male ,medicine.medical_specialty ,Serotonergic ,Synaptic Transmission ,Ventriculoperitoneal Shunt ,Cerebral Ventricles ,Glutamatergic ,chemistry.chemical_compound ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,Neocortex ,Mental Disorders ,Homovanillic acid ,Homovanillic Acid ,Hydroxyindoleacetic Acid ,Middle Aged ,medicine.disease ,Antidepressive Agents ,Psychiatry and Mental health ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Surgery ,Female ,Neurology (clinical) ,Serotonin ,Alzheimer's disease ,Psychology ,Homovanillate ,Acetylcholine ,medicine.drug ,Antipsychotic Agents ,Research Article - Abstract
Aspartic acid, 5-hydroxyindoleacetic acid, glutamic acid, homovanillic acid and 3-methoxy-4-hydroxyphenylethylene glycol was determined in samples of ventricular fluid from 82 subjects. Laminar distribution of the total number (Bmax value) of serotonin 1A receptors was determined on seven neurosurgical samples of neocortex. Apart from an association in a small subgroup of subjects between homovanillate concentration and corticosteroid medication, no complicating influences of treatment preceding operation were found. The content of the serotonin metabolite alone was significantly reduced in intractable depressive illness (bipolar and major depressive disorders) compared with neurological conditions subdivided into Alzheimer's disease, other dementias and other conditions. There was no other significant difference between these groups for the compounds measured. The total number of serotonin 1A receptors was highest in the superficial layers, being considerably higher than in the rat, irrespective of cortical layer. This part of the study indicated that these receptors are important for regulating activity of human corticocortical glutamatergic neurons. The results are discussed in relation to treating depression with serotonergic agents and targeting corticocortical glutamatergic neurons as well as acetylcholine in Alzheimer's disease.
- Published
- 1993
24. Effect of psychotropic drugs on excitatory amino acids in patients undergoing psychosurgery for depression
- Author
-
Andrea Malizia, Paulo Henrique Ferreira Bertolucci, Paul T. Francis, M. N. Pangalos, J R Bartlett, P K Bridges, David M. Bowen, Andrew W. Procter, and S. L. Lowe
- Subjects
Adult ,Male ,Bipolar Disorder ,Brain damage ,Pharmacology ,Receptors, N-Methyl-D-Aspartate ,Serine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Asparagine ,Amino Acids ,Electroconvulsive Therapy ,Psychiatric Status Rating Scales ,Depressive Disorder ,Neurotransmitter Agents ,Psychotropic Drugs ,business.industry ,Glutamate receptor ,Glutamic acid ,Middle Aged ,Combined Modality Therapy ,030227 psychiatry ,Psychosurgery ,Glutamine ,Psychiatry and Mental health ,Psychotropic drug ,Anesthesia ,Female ,medicine.symptom ,Caudate Nucleus ,business ,Follow-Up Studies - Abstract
Samples of ventricular CSF were taken from 52 consecutive patients admitted for psychosurgery for intractable depression. Concentrations of asparagine, aspartate, glutamine, glutamic acid, and serine were determined. Glutamate and aspartate concentrations, implicated in excitotoxic brain damage, were not affected by various types of psychotropic drug treatment. Serine, a modulator of glutamate responses, was significantly elevated in samples from subjects receiving antidepressants. These subjects responded poorly to the operation. Psychotropic drugs are unlikely to be neurotoxic. Nevertheless, antidepressants may influence excitatory neurotransmission.
- Published
- 1992
25. REVIEWS
- Author
-
J. R. BARTLETT
- Subjects
Religious studies - Published
- 2000
26. Depression: a role for neurosurgery?
- Author
-
S. Malhi, J. R. Bartlett, G., primary
- Published
- 2000
- Full Text
- View/download PDF
27. Chronic subdural haematoma
- Author
-
J R Bartlett and Paul Byrne
- Subjects
medicine.medical_specialty ,business.industry ,General Medicine ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Chronic subdural haematoma ,Hematoma, Subdural ,Hematoma ,Text mining ,Chronic Disease ,Trephining ,medicine ,Humans ,Neurology (clinical) ,Tomography, X-Ray Computed ,business - Published
- 1991
28. Neurosurgery for obsessive-compulsive disorder
- Author
-
J R Bartlett and G S Malhi
- Subjects
Psychiatry and Mental health ,medicine.medical_specialty ,Obsessive compulsive ,business.industry ,medicine.medical_treatment ,Stereotaxic technique ,medicine ,Neurosurgery ,Psychiatry ,business ,Electrocoagulation - Published
- 1998
29. Effect of SolGel Encapsulation on Lipase Structure and Function: A Small Angle Neutron Scattering Study.
- Author
-
L. E. Rodgers, P. J. Holden, R. B. Knott, K. S. Finnie, J. R. Bartlett, and L. J. R. Foster
- Subjects
NEUTRONS ,ATOMS ,BARYONS ,CONSTITUTION of matter - Abstract
Abstract The application of small angle neutron scattering (SANS) to the characterisation of solgel hosts containing biomolecules offers the opportunity to explore the relationship between gel structure and catalyst. A model system involving the immobilisation of Candida antarctica lipase B (CALB) was investigated. [ABSTRACT FROM AUTHOR]
- Published
- 2005
30. Edom and the Edomites
- Author
-
J. A. Emerton and J. R. Bartlett
- Subjects
Linguistics and Language ,History ,Literature and Literary Theory ,Religious studies ,Language and Linguistics - Published
- 1990
31. The use of analysis of covariance in the back-calculation of growth in fish
- Author
-
J. R. Bartlett, D. M. Ellis, Peter Frederick Randerson, and R. Williams
- Subjects
Analysis of covariance ,Linear regression ,Statistics ,%22">Fish ,Aquatic Science ,Biology ,Covariance ,Ecology, Evolution, Behavior and Systematics ,Back calculation - Published
- 1984
32. Psychosurgery: Yesterday and Today
- Author
-
P K Bridges and J R Bartlett
- Subjects
History ,Mental Disorders ,Art history ,History, 19th Century ,History, 20th Century ,Amygdala ,Yesterday ,Frontal Lobe ,Psychosurgery ,030227 psychiatry ,Stereotaxic Techniques ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Humans ,Ethics, Medical ,030212 general & internal medicine ,Orbit - Published
- 1977
33. Ventricular Size and CSF Transmitter Metabolite Concentrations in Severe Endogenous Depression
- Author
-
P K Bridges, A. S. Hale, H. M. A. S. Standish-Barry, Nick Bouras, and J. R. Bartlett
- Subjects
Adult ,Male ,medicine.medical_specialty ,Metabolite ,Cerebral Ventricles ,Ventricular CSF ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,cardiovascular diseases ,030212 general & internal medicine ,Neurotransmitter ,Aged ,Depressive Disorder ,Neurotransmitter Agents ,Ventricular size ,business.industry ,Tryptophan ,Hydroxyindoleacetic Acid ,Middle Aged ,030227 psychiatry ,Psychiatry and Mental health ,Endocrinology ,chemistry ,Free tryptophan ,Ventricular enlargement ,Endogenous depression ,cardiovascular system ,Female ,business - Abstract
The relationship between neurotransmitter metabolite concentrations and measurements of ventricular size on CAT scans and pneumoencephalographs was investigated in 15 patients with severe affective disorder. An association was identified between reduced levels of plasma free tryptophan and ventricular enlargement and also between raised ventricular CSF levels of 5 HIAA and ventricular enlargement.
- Published
- 1986
34. Evaluating cost-effectiveness of diagnostic equipment: the brain scanner case
- Author
-
D G Cruickshank, J R Bartlett, J M Banham, and G Neil-Dwyer
- Subjects
Scanner ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,Cat scanning ,Diagnostic equipment ,Craniocerebral Trauma ,Humans ,Medicine ,Medical physics ,Computerised axial tomography ,Health Services Administration ,Simulation ,General Environmental Science ,Health Services Needs and Demand ,business.industry ,General Engineering ,Brain ,General Medicine ,Craniocerebral trauma ,Tomography x ray computed ,England ,Evaluation Studies as Topic ,Costs and Cost Analysis ,General Earth and Planetary Sciences ,Air Encephalography ,Tomography, X-Ray Computed ,business ,Research Article - Abstract
An approach to evaluating the cost-effectiveness of high-technology diagnostic equipment has been devised, using the introduction of computerised axial tomography (CAT) as a model. With the advent of CAT scanning, angiography and air encephalography have a reduced, though important, role in investigating intracranial disease, and the efficient use of conventional equipment requires the centralisation of neuroradiological services, which would result in major cash savings. In contrast, the pattern of demand for CAT scanning, in addition to the acknowledged clinical efficiency of the scanner and its unique role in the head-injured patient, ephasies the need for improved access to scanners. In the interest of the patients the pattern of service must change.
- Published
- 1978
35. Geochronology of the Belmont Lake Metavolcanic Complex and implications for crustal development in the Central Metasedimentary Belt, Grenville Province, Ontario
- Author
-
J. R. Bartlett and D. W. Davis
- Subjects
geography ,geography.geographical_feature_category ,Geochemistry ,Metamorphism ,engineering.material ,Dacite ,Sequence (geology) ,Volcano ,Titanite ,Rhyolite ,Geochronology ,engineering ,General Earth and Planetary Sciences ,Geology ,Zircon - Abstract
U–Pb analyses of zircon and titanite were carried out on eight rocks from the Belmont Lake Metavolcanic Complex, a volcano-sedimentary sequence in the Central Metasedimentary Belt of the Grenville Province of southeastern Ontario. The ages of concordant supracrustal rocks within the complex do not accord with stratigraphic position.The youngest volcanic age is [Formula: see text] from a rhyolite near the base of the sequence. The oldest age, [Formula: see text], is from a dacite in the middle. This is overlain by a rhyolite [Formula: see text] in age. A rhyolite at the top of the sequence appears to contain zircon inherited from a source about 1870 Ma old. The complex is therefore interpreted as comprising a lithotectonic sequence composed of structurally interleaved segments of contrasting age. Tectonic emplacement of these segments was most likely along previously unrecognized thrust faults.The supracrustal rocks were subjected to at least two major deformational events as well as a late metamorphism. The earliest event was probably associated with thrusting. The age of the youngest volcanic unit, [Formula: see text], is an upper age estimate for this event. A lower estimate is probably given by the age of the Cordova Gabbro, 1242 ± 3 Ma. The later event, including peak regional metamorphism, should be younger than [Formula: see text], the age of a sheared, recrystallized felsic sill intruded into the supracrustal rocks, and older than [Formula: see text], the age of the undeformed and unmetamorphosed Belmont Granite.Titanite fractions in the Belmont Granite and a volcanic andesite both give an age of 1071 ± 5 Ma. The age from titanite in the Belmont Granite may be due to thermal resetting during slow cooling. Titanite in the andesite is secondary and may have grown as a result of late metamorphic reactions.The youngest age measured, 1039 ± 5 Ma, is from a concordant analysis of a single zircon grain found within the oldest rhyolite. This may be an example of zircon growth from low-temperature, late-metamorphic fluids.
- Published
- 1988
36. Indolic Substances in Plasma, Cerebrospinal Fluid, and Frontal Cortex of Human Subjects Infused with Saline or Tryptophan
- Author
-
B. D. Kantamaneni, A. J. Patel, P. K. Bridges, P. K. Gillman, Gerald Curzon, A. Hunt, and J. R. Bartlett
- Subjects
Serotonin ,medicine.medical_specialty ,Indoles ,medicine.medical_treatment ,Sodium Chloride ,Blood–brain barrier ,Biochemistry ,Cellular and Molecular Neuroscience ,Cerebrospinal fluid ,Cortex (anatomy) ,Internal medicine ,medicine ,Humans ,Saline ,Tryptophan transport ,Cerebral Cortex ,chemistry.chemical_classification ,Chemistry ,Tryptophan ,Homovanillic Acid ,Hydroxyindoleacetic Acid ,Amino acid ,Kinetics ,medicine.anatomical_structure ,Endocrinology ,Cerebral cortex - Abstract
Psychiatric patients undergoing the psychosurgical operation of stereotactic subcaudate tractotomy were infused intravenously with either saline or L-tryptophan (15 mg/kg/h). Plasma, lumbar cerebrospinal fluid (CSF), ventricular CSF and a specimen of frontal cortex were collected. The relationships of plasma concentrations of substances claimed to influence brain tryptophan concentration (total tryptophan, free tryptophan, large neutral amino acids) with the concentration of tryptophan in the cortex and CSF were investigated. Tryptophan infusion resulted in plasma tryptophan values comparable to those found after oral doses used in treating depression or insomnia, and about sixfold increases of tryptophan in the cerebral cortex. Increased brain 5-hydroxytryptamine synthesis was indicated by significant rises of CSF 5-hydroxyindoleacetic acid. The concentration of plasma free tryptophan was a better predictor than plasma total tryptophan of cortex tryptophan concentration. As all correlation coefficients of plasma versus brain or plasma versus ventricular CSF tryptophan concentrations were decreased when allowance was made for differences of concentration of large neutral amino acids, the results suggest that the role of these substances within their physiological range as inhibitors of tryptophan transport to the brain may previously have been overemphasised.
- Published
- 1981
37. Psychosurgery in Britain Now
- Author
-
J R Bartlett, Amanda Poynton, and P K Bridges
- Subjects
medicine.medical_specialty ,business.industry ,Mental Health Act ,Legislation as Topic ,Late onset ,Psychotic depression ,General Medicine ,medicine.disease ,United Kingdom ,Psychosurgery ,Mood ,Schizophrenia ,Endogenous depression ,medicine ,Humans ,Surgery ,Neurology (clinical) ,medicine.symptom ,Psychiatry ,business ,Mania - Abstract
Between 1979 and 1986 the number of psychosurgical operations carried out in Britain fell from 70 to 15 procedures annually. There are a number of possible reasons for this change of which increased experience with new regimes of psychotropic medication is perhaps the most important. The new Mental Health Act (1983) which brought psychosurgery under the direct jurisdiction of the law was followed by a sudden reduction in the number of patients treated but referals are now increasing. In current psychiatric practice, classification relies largely on description of syndromes, each characterised by a set of core symptoms. Schizophrenia and affective psychoses (endogenous depression, mania and obsessional illness of late onset) are characterised by disturbances of mood, thinking and perception often so profound as to impair the patient's contact with reality. In contrast, neuroses produce symptoms which are quantitatively, rather than qualitatively different from normal experience and psychosurgery has no place in their treatment. Following the introduction of phenothiazines in the early 1950's schizophrenia ceased to be an indication for psychosurgery. For a small group of severely disabled and distressed people suffering from endogenous depressive and obsessional illnesses, when other treatments have failed or ceased to be effective, psychosurgery remains an appropriate treatment. Just over half the patients treated at the Geoffrey Knight Unit are relieved to the extent that they are either free of symptoms or such symptoms that remain do not significantly impair social function. Following operation recovery is slow and progressive and a programme of rehabilitation is usually necessary. Personality which is often severely damaged by the effects of long illness returns towards normal. Neuropsychiatric evaluation has consistently failed to demonstrate adverse cognitive effects. Evaluation and selection of patients for operation should be done by a psychiatrist and neurosurgeon working in partnership. Stereotactic techniques have made it possible to produce precisely located lesions of consistent size, virtually eliminating side effects and reducing the epileptic risk to between two and three percent. The Mental Health Act, contrary to early expectations, has allowed that psychosurgery retains a place in the treatment of a small highly selected group of patients.
- Published
- 1988
38. Contemporary Indications for Psychosurgery
- Author
-
Desmond Kelly, J R Bartlett, and P K Bridges
- Subjects
Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Enthusiasm ,Mood Disorders ,business.industry ,media_common.quotation_subject ,Prognosis ,Psychosurgery ,030227 psychiatry ,Objective assessment ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Schizophrenia ,Humans ,Medicine ,030212 general & internal medicine ,Surgical treatment ,business ,Intensive care medicine ,Period (music) ,Personality ,media_common - Abstract
The initial period of enthusiasm for the surgical treatment of certain psychiatric illnesses, has later given way to increasing rejection of this mode of therapy. But more recently there has been a reappraisal of the therapeutic possibilities of the modern refined operations, which are now receiving more objective assessment.
- Published
- 1981
39. Review Article: Mapping the Bible
- Author
-
J. R. Bartlett
- Subjects
Archeology ,History ,Visual Arts and Performing Arts ,Religious studies ,Art history ,Palestine ,Review article - Abstract
(1982). Review Article: Mapping the Bible. Palestine Exploration Quarterly: Vol. 114, No. 2, pp. 147-153.
- Published
- 1982
40. Correlations between transmitter metabolite concentrations in human ventricular cerebrospinal fluid and pattern visual-evoked potentials
- Author
-
B. D. Kantamaneni, P. K. Bridges, G.E. Holder, Gerald Curzon, and J. R. Bartlett
- Subjects
Adult ,Male ,Metabolite ,chemistry.chemical_compound ,Cerebrospinal fluid ,Dopamine ,medicine ,Humans ,Evoked Potentials ,Molecular Biology ,Phenylacetates ,Cerebral Cortex ,business.industry ,General Neuroscience ,Homovanillic Acid ,Hydroxyindoleacetic Acid ,Middle Aged ,Form Perception ,Pattern Recognition, Visual ,Pattern visual evoked potentials ,chemistry ,Female ,Neurology (clinical) ,business ,Neuroscience ,Photic Stimulation ,Developmental Biology ,medicine.drug - Published
- 1980
41. Amino acid levels in depression: A preliminary investigation
- Author
-
A. Honig, P. K. Bridges, J. R. Bartlett, and Nick Bouras
- Subjects
Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Psychometrics ,chemistry.chemical_compound ,Cerebrospinal fluid ,Internal medicine ,Blood plasma ,medicine ,Humans ,Bipolar disorder ,Amino Acids ,Family history ,Neurotransmitter ,Biological Psychiatry ,Depression (differential diagnoses) ,Depressive Disorder ,Psychological Tests ,Middle Aged ,medicine.disease ,Frontal Lobe ,Psychosurgery ,Psychiatry and Mental health ,Endocrinology ,chemistry ,Frontal lobe ,Blood-Brain Barrier ,Anxiety ,Female ,medicine.symptom ,Psychology - Abstract
Plasma, cerebrospinal fluid and brain tissue amino acid levels were measured in 14 patients with affective illness and generally confirm previous findings. There was no correlation between these values and age, sex, family history and levels of anxiety. GABA levels measured in cortex tissue were negatively correlated with depressive mood (P less than 0.05), supporting a possible involvement of GABA in depressive illness.
- Published
- 1988
42. A Neuroendocrine Study of Stereotactic Sub-Caudate Tractotomy
- Author
-
Chris Thompson, Stuart A. Checkley, P K Bridges, T H Corn, A. Honig, and J. R. Bartlett
- Subjects
Male ,Caudate nucleus ,Blood Pressure ,Neuroendocrinology ,Clonidine ,Stereotaxic Techniques ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,030212 general & internal medicine ,Depression (differential diagnoses) ,Aged ,Depressive Disorder ,business.industry ,Middle Aged ,Receptors, Adrenergic, alpha ,Psychosurgery ,030227 psychiatry ,Psychiatry and Mental health ,Blood pressure ,Growth Hormone ,Anesthesia ,Stereotaxic technique ,Antidepressant ,Female ,Caudate Nucleus ,business ,medicine.drug - Abstract
SummaryThe growth hormone and hypotensive responses to clonidine have been measured in six drug free severely depressed patients before, and at two weeks after, the surgical procedure of stereotactic sub-caudate tractotomy. The responses were unaltered two weeks after operation, by which time a small clinical improvement was evident. These findings are discussed in relation to central a adrenoceptor functions in depression, and the effect upon this of antidepressant treatment.
- Published
- 1984
43. Studies of endocrine activity, plasma tryptophan and catecholamine excretion on psychosurgical patients
- Author
-
P. Sepping, J. R. Bartlett, P. K. Bridges, P. O'Gorman, V. K. Patel, C. Bellamy, and W. Wood
- Subjects
Adult ,Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Epinephrine ,Hydrocortisone ,Personality Inventory ,Urinary system ,Anxiety ,Dexamethasone ,Excretion ,Lesion ,Norepinephrine ,Internal medicine ,medicine ,Humans ,Endocrine system ,Depression (differential diagnoses) ,Clinical Trials as Topic ,Depression ,Tryptophan ,Middle Aged ,Psychosurgery ,Psychiatry and Mental health ,Endocrinology ,Catecholamine ,Female ,medicine.symptom ,Psychology ,medicine.drug - Abstract
The Geoffrey Knight Psychosurgical Unit admits patients on a regular basis and thus offers special opportunities for studying severely ill psychiatric cases, all having one particular treatment under relatively controlled conditions. The opportunity has been taken to repeat various metabolic studies previously reported to be abnormal in some psychiatric illnesses. In the present investigation several measures of endocrinological activity were studied, as was plasma tryptophan, both free and bound. None of these data confirmed reports of abnormalities and neither did the values found at operation help to predict clinical outcome 1 year later, which was another possibility. Urinary catecholamines were also measured before and 2 weeks after operation. Male patients, regardless of diagnosis, showed a mean increase in adrenaline output after operation compared with the pre-operative value and this was significantly different from the females, who showed a small mean decrease. The depressed patients showed a significant reduction in noradrenaline excretion after operation compared with before operation and this trend was enhanced in those of good outcome at 1 year, the difference from those who responded poorly being significant. It could be that the ventromedial lesion that is produced alters noradrenaline metabolism or autonomic activity in depression and this possibility merits further study.
- Published
- 1977
44. Electroencephalographic changes as prognostic indicators after psychosurgery
- Author
-
P K Bridges, J R Bartlett, and Bidi M Evans
- Subjects
Adult ,Male ,Brain Diseases ,medicine.medical_specialty ,medicine.diagnostic_test ,Electroencephalography ,Middle Aged ,Audiology ,Prognosis ,Frontal Lobe ,Psychosurgery ,Psychiatry and Mental health ,Short Reports ,Frontal lobe ,Significant positive correlation ,medicine ,Humans ,Female ,Surgery ,Neurology (clinical) ,Psychology ,Psychiatry ,Aged - Abstract
Thirty-five patients were studied by EEG with recordings taken the day before, two weeks after, and six months after psychosurgery. Most showed a characteristic frontal slow activity of varying degrees after operation with varying enhancement of background activity. The amount and spread of the frontal slow waves two weeks after operation showed a significant positive correlation with the clinical outcome one year later, which suggests a relatively objective and very early indication of the subsequent clinical response to psychosurgery.
- Published
- 1981
45. Computer simulation of a microbial genetics experiment as a learning aid for undergraduate teaching
- Author
-
J. R. Bartlett, Peter Frederick Randerson, and M. J. Day
- Subjects
Background information ,Computer program ,Relation (database) ,business.industry ,Conceptual model (computer science) ,Mathematics education ,General Agricultural and Biological Sciences ,Software engineering ,business ,Science education ,Data treatment ,Education ,Pace - Abstract
This paper reports the design of an interactive computer program in microbial genetics. The computer program is divided into three stages, background information, simulation, and data treatment. The results obtained from the simulation allow four genes to be sequenced along the bacterial chromosome. The simulation mimics experimental errors, the production of exconjugants and backmutants. The data can be analysed using options contained in the program. The simulation is of particular educational value because it allows the student to work at his own pace and to develop his ability to analyse data in relation to a complex conceptual model.
- Published
- 1983
46. A clinical study of the EMI scanner: implications for provision of neuroradiological services
- Author
-
J R Bartlett and G Neil-Dwyer
- Subjects
Brain Diseases ,medicine.medical_specialty ,Scanner ,education.field_of_study ,business.industry ,Radiography ,Population ,Angiography ,General Engineering ,General Medicine ,Clinical study ,Tomography x ray computed ,EMI ,Costs and Cost Analysis ,Methods ,medicine ,Humans ,General Earth and Planetary Sciences ,Medical physics ,Tomography, X-Ray Computed ,business ,education ,Research Article ,General Environmental Science - Abstract
The records of the first 571 patients to be examined with an EMI brain scanner were assessed. The patients were divided into diagnostic categories according to their clinical presentation. The intracranial investigations that would have been performed had the scanner not been available were compared with the investigations that were actually performed. As expected, the number of contrast investigations fell, but the reduction surpassed expectation. If the full clinical impact of the scanner is to be realised the patient's illness must be defined in detail and strict attention paid to radiographic detail. By reducing the number of special contrast investigations use of the scanner enables existing contrast facilities to serve a wider population; and use of the brain scanner in district general hospitals would improve the service to patients, especially those with head injuries.
- Published
- 1978
47. Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem
- Author
-
A. Najlerahim, P. K. Bridges, Paul T. Francis, Andrew W. Procter, S. L. Lowe, David M. Bowen, A. Poynton, J. R. Bartlett, and C.J. Bruton
- Subjects
Agonist ,Male ,medicine.medical_specialty ,medicine.drug_class ,Glutamic Acid ,Brain tissue ,Biology ,chemistry.chemical_compound ,Glutamates ,Internal medicine ,medicine ,Humans ,Molecular Biology ,Homocysteine ,Depression (differential diagnoses) ,gamma-Aminobutyric Acid ,Aged ,chemistry.chemical_classification ,Aged, 80 and over ,Aspartic Acid ,Depressive Disorder ,General Neuroscience ,Glutamate receptor ,Glutamic acid ,Human brain ,Middle Aged ,Homocysteic acid ,Amino acid ,Frontal Lobe ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Biochemistry ,Calcium ,Female ,Neurology (clinical) ,Developmental Biology - Abstract
The concentrations of 3 putative neurotransmitters (glutamate, aspartate and γ-aminobutyrate), 4 related amino acids and 5 non-transmitter-related amino acids have been measured in neurosurgical samples (frontal cortex) from patients with intractable depression and controls. In addition, the glutamate receptor agonist 2-amino-4-sulpho-butanoic acid (homocysteic acid) has been identified in human brain and measured in these samples. There were no changes in the concentrations of amino acids in depressed patients compared to control with the exception of aspartic and homocysteic acids which were elevated in a sub-group of patients with depression compared to control. The Ca 2+ -dependent release (K + -stimulated) of putative neurotransmitters has been demonstrated for the first time from brain tissue of depressed patients. Glutamate release was unaltered from the control value. Aspartate values showed unexplained variability but it's release and that of γ-aminobutyrate were elevated in some depressed subjects. These results do not support the hypothesis of reduced amino acid function in depressive illness.
- Published
- 1989
48. Pneumo-encephalographic and computerized axial tomography scan changes in affective disorder
- Author
-
P. K. Bridges, H. M. A. S. Standish-Barry, J. R. Bartlett, and Nick Bouras
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cephalometry ,Cerebral Ventricles ,03 medical and health sciences ,0302 clinical medicine ,Axial tomography ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Aged ,Ventricular size ,business.industry ,Mood Disorders ,Brain ,Middle Aged ,030227 psychiatry ,Psychiatry and Mental health ,Ventricular enlargement ,Cardiology ,Female ,business ,Pneumoencephalography ,Tomography, X-Ray Computed - Abstract
SummaryThe pneumo-encephalographs and computerized axial tomography scans of fifty patients with severe affective disorder were studied. Measures of ventricular size were compared with those reported by other workers. Findings suggested that some patients suffering from severe affective illness showed abnormalities of brain structure as demonstrated by ventricular enlargement.
- Published
- 1982
49. Resistant bipolar affective disorder treated by stereotactic subcaudate tractotomy
- Author
-
P K Bridges, J R Bartlett, and Amanda Poynton
- Subjects
Pediatrics ,medicine.medical_specialty ,Bipolar Disorder ,Middle Aged ,medicine.disease ,030227 psychiatry ,Manic depressive psychosis ,Psychosurgery ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,mental disorders ,medicine ,Humans ,Female ,030212 general & internal medicine ,Bipolar disorder ,Psychiatry ,Psychology ,Depression (differential diagnoses) ,Follow-Up Studies - Abstract
The results of stereotactic subcaudate tractotomy in nine patients with resistant bipolar affective disorder are presented in the form of a single case study with a summary of the other eight cases. Follow-up studies at 2–4 years showed substantial improvement in five patients and amelioration of symptoms in a further four patients, with a tendency for a greater improvement in the manic than in the depressive episodes. These preliminary results suggest that there is a place for this operation in the management of severe bipolar affective disorders which are not responding to any other treatment, although decisive recovery occurs less often than with unipolar depression.
- Published
- 1988
50. Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients
- Author
-
J. R. Bartlett, P. Sepping, P. K. Bridges, B. D. Kantamaneni, and Gerald Curzon
- Subjects
Adult ,Male ,medicine.medical_specialty ,Obsessive-Compulsive Disorder ,Metabolite ,Cerebral Ventricles ,chemistry.chemical_compound ,Cerebrospinal fluid ,Dopamine ,medicine ,Humans ,Tyrosine ,Psychiatry ,Applied Psychology ,Aged ,Phenylacetates ,chemistry.chemical_classification ,Brain Diseases ,Chemistry ,Depression ,Mental Disorders ,Homovanillic acid ,Tryptophan ,Homovanillic Acid ,Hydroxyindoleacetic Acid ,Middle Aged ,medicine.disease ,Anxiety Disorders ,Amino acid ,Psychiatry and Mental health ,Schizophrenia ,Female ,medicine.drug - Abstract
SynopsisTryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptaminę) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Results suggest an association between affective state and the above precursor amino acids with lower concentrations in primary depression and higher ones when anxiety or agitation predominate. This leads to lower 5-hydroxyindoleacetic acid concentrations in depression and higher concentrations in anxiety and agitation.
- Published
- 1976
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.