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335 results on '"Iwamoto, Kunihiro"'

6. Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder

Author

Kushima, Itaru, Nakatochi, Masahiro, Aleksic, Branko, Okada, Takashi, Kimura, Hiroki, Kato, Hidekazu, Morikawa, Mako, Inada, Toshiya, Ishizuka, Kanako, Torii, Youta, Nakamura, Yukako, Tanaka, Satoshi, Imaeda, Miho, Takahashi, Nagahide, Yamamoto, Maeri, Iwamoto, Kunihiro, Nawa, Yoshihiro, Ogawa, Nanayo, Iritani, Shuji, Hayashi, Yu, Lo, Tzuyao, Otgonbayar, Gantsooj, Furuta, Sho, Iwata, Nakao, Ikeda, Masashi, Saito, Takeo, Ninomiya, Kohei, Okochi, Tomo, Hashimoto, Ryota, Yamamori, Hidenaga, Yasuda, Yuka, Fujimoto, Michiko, Miura, Kenichiro, Itokawa, Masanari, Arai, Makoto, Miyashita, Mitsuhiro, Toriumi, Kazuya, Ohi, Kazutaka, Shioiri, Toshiki, Kitaichi, Kiyoyuki, Someya, Toshiyuki, Watanabe, Yuichiro, Egawa, Jun, Takahashi, Tsutomu, Suzuki, Michio, Sasaki, Tsukasa, Tochigi, Mamoru, Nishimura, Fumichika, Yamasue, Hidenori, Kuwabara, Hitoshi, Wakuda, Tomoyasu, Kato, Takahiro A., Kanba, Shigenobu, Horikawa, Hideki, Usami, Masahide, Kodaira, Masaki, Watanabe, Kyota, Yoshikawa, Takeo, Toyota, Tomoko, Yokoyama, Shigeru, Munesue, Toshio, Kimura, Ryo, Funabiki, Yasuko, Kosaka, Hirotaka, Jung, Minyoung, Kasai, Kiyoto, Ikegame, Tempei, Jinde, Seiichiro, Numata, Shusuke, Kinoshita, Makoto, Kato, Tadafumi, Kakiuchi, Chihiro, Yamakawa, Kazuhiro, Suzuki, Toshimitsu, Hashimoto, Naoki, Ishikawa, Shuhei, Yamagata, Bun, Nio, Shintaro, Murai, Toshiya, Son, Shuraku, Kunii, Yasuto, Yabe, Hirooki, Inagaki, Masumi, Goto, Yu-ichi, Okumura, Yuto, Ito, Tomoya, Arioka, Yuko, Mori, Daisuke, and Ozaki, Norio

Published
2022
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8. Copy number variations in RNF216 and postsynaptic membrane–associated genes are associated with bipolar disorder: a case‐control study in the Japanese population.

Author

Nakatochi, Masahiro, Kushima, Itaru, Aleksic, Branko, Kimura, Hiroki, Kato, Hidekazu, Inada, Toshiya, Torii, Youta, Takahashi, Nagahide, Yamamoto, Maeri, Iwamoto, Kunihiro, Nawa, Yoshihiro, Iritani, Shuji, Iwata, Nakao, Saito, Takeo, Ninomiya, Kohei, Okochi, Tomo, Hashimoto, Ryota, Yamamori, Hidenaga, Yasuda, Yuka, and Fujimoto, Michiko

Subjects
JAPANESE people, BIPOLAR disorder, GENE ontology, ODDS ratio, DATABASES
Abstract

Aim: Bipolar disorder (BD) is a common psychiatric disorder characterized by alterations between manic/hypomanic and depressive states. Rare pathogenic copy number variations (CNVs) that overlap with exons of synaptic genes have been associated with BD. However, no study has comprehensively explored CNVs in synaptic genes associated with BD. Here, we evaluated the relationship between BD and rare CNVs that overlap with synaptic genes, not limited to exons, in the Japanese population. Methods: Using array comparative genome hybridization, we detected CNVs in 1839 patients with BD and 2760 controls. We used the Synaptic Gene Ontology database to identify rare CNVs that overlap with synaptic genes. Using gene‐based analysis, we compared their frequencies between the BD and control groups. We also searched for synaptic gene sets related to BD. The significance level was set to a false discovery rate of 10%. Results: The RNF216 gene was significantly associated with BD (odds ratio, 4.51 [95% confidence interval, 1.66–14.89], false discovery rate < 10%). The BD‐associated CNV that corresponded with RNF216 also partially overlapped with the minimal critical region of the 7p22.1 microduplication syndrome. The integral component of the postsynaptic membrane (Gene Ontology:0099055) was significantly associated with BD. The CNV overlapping with the intron region of GRM5 in this gene set showed a nominal significant association between cases and controls (P < 0.05). Conclusion: We provide evidence that CNVs in RNF216 and postsynaptic membrane–related genes confer a risk of BD, contributing to a better understanding of the pathogenesis of BD. [ABSTRACT FROM AUTHOR]

Published
2025
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9. Effects of frequently prescribed antiseizure medications on motor vehicle driving performance: Narrative review based on a tiered approach for the assessment of clinically meaningful driving impairment in the Ministry of Health, Labour, and Welfare guideline

Author

Iwamoto, Kunihiro, Nakabayashi, Tetsuo, Yamaguchi, Akiko, Konishi, Yuki, Saji, Momoe, Yoshimura, Reiji, Kanemoto, Kousuke, Aoki, Hirofumi, Ando, Masahiko, and Ozaki, Norio

Subjects
*PSYCHOPHARMACOLOGY, *TRAFFIC safety, *DRUG administration, *TRAFFIC accidents, *VALPROIC acid
Abstract

Patients with epilepsy often require long‐term treatment with antiseizure medications, and their impact on daily activities, particularly driving, is of significant concern. The recently published "Guideline for Evaluating Effects of Psychotropic Drugs on the Performance to Drive a Motor Vehicle" in Japan provides a framework that can be referred to for not only the evaluation of new drugs but also the reevaluation of approved drugs. This study conducted a literature review regarding the effects of carbamazepine, valproate, lamotrigine, lacosamide, and levetiracetam, which are frequently prescribed for epilepsy, on driving performance following the guideline's tiered evaluation approach. Analyses of pharmacological, pharmacodynamic, and adverse events suggested that these drugs primarily affect arousal function. Driving studies showed that acute administration of carbamazepine, but not chronic monotherapy with carbamazepine, valproate, lamotrigine, and levetiracetam, significantly impairs driving performance. Epidemiological studies have not identified a definitive association between these drugs and traffic accidents. Initial administration of these five antiseizure medications may affect driving performance, warranting special attention, but the influence appears to diminish with continued use. Nevertheless, while long‐term administration of these five drugs may not have a clinically meaningful effect on driving performance, safe driving is not guaranteed for each individual patient, and appropriate individualized guidance is important in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Guideline for evaluating the effects of psychotropic drugs on motor vehicle driving performance in Japan: A tiered approach for the assessment of clinically meaningful driving impairment

Author

Nakabayashi, Tetsuo, primary, Iwamoto, Kunihiro, additional, Yamaguchi, Akiko, additional, Konishi, Yuki, additional, Saji, Momoe, additional, Yoshimura, Reiji, additional, Kanemoto, Kousuke, additional, Aoki, Hirofumi, additional, Ando, Masahiko, additional, and Ozaki, Norio, additional

Published
2024
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13. Assessing the Real-World, Long-Term Impact of Lemborexant on Sleep Quality in a Home-Based Clinical Study

Author

Miyata, Seiko, primary, Iwamoto, Kunihiro, additional, Okada, Ippei, additional, Fujimoto, Akihiro, additional, Kogo, Yuki, additional, Mori, Daisuke, additional, Amano, Manabu, additional, Matsuyama, Nao, additional, Nishida, Kazuki, additional, Ando, Masahiko, additional, Taoka, Toshiaki, additional, Naganawa, Shinji, additional, and Ozaki, Norio, additional

Published
2024
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15. Assessing the Real-World, Long-Term Impact of Lemborexant on Sleep Quality in a Home-Based Clinical Study

Author

Miyata,Seiko, Iwamoto,Kunihiro, Okada,Ippei, Fujimoto,Akihiro, Kogo,Yuki, Mori,Daisuke, Amano,Manabu, Matsuyama,Nao, Nishida,Kazuki, Ando,Masahiko, Taoka,Toshiaki, Naganawa,Shinji, Ozaki,Norio, Miyata,Seiko, Iwamoto,Kunihiro, Okada,Ippei, Fujimoto,Akihiro, Kogo,Yuki, Mori,Daisuke, Amano,Manabu, Matsuyama,Nao, Nishida,Kazuki, Ando,Masahiko, Taoka,Toshiaki, Naganawa,Shinji, and Ozaki,Norio

Abstract

Seiko Miyata,1,&ast; Kunihiro Iwamoto,1,&ast; Ippei Okada,1,&ast; Akihiro Fujimoto,2 Yuki Kogo,2 Daisuke Mori,1,3,4 Manabu Amano,5 Nao Matsuyama,5 Kazuki Nishida,5 Masahiko Ando,5 Toshiaki Taoka,6 Shinji Naganawa,7 Norio Ozaki1,4 1Department of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Japan; 2Medical Headquarters, Eisai Co., Ltd., Tokyo, Japan; 3Brain and Mind Research Center, Nagoya University, Nagoya, Japan; 4Pathophysiology of Mental Disorders, Nagoya University, Graduate School of Medicine, Nagoya, Japan; 5Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan; 6Department of Innovative Biomedical Visualization (Ibmv), Nagoya University, Graduate School of Medicine, Nagoya, Japan; 7Department of Radiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan&ast;These authors contributed equally to this workCorrespondence: Seiko Miyata, Department of Psychiatry, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan, Tel +81 52 744 2282, Fax +81 52 744 2293, Email miyata.seiko.v4@f.mail.nagoya-u.ac.jpPurpose: Both subjective and objective evaluations are essential for the treatment of insomnia. Lemborexant has been shown to be effective in the long-term based solely on a subjective basis, and no long-term objective measures have been evaluated under natural sleep conditions. Small, lightweight sleep electroencephalogram (EEG) monitor was used, instead of polysomnography, to objectively evaluate sleep at home 4 and 12 weeks after lemborexant treatment.Patients and Methods: Adults and elderly subjects with insomnia disorder, per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, were enrolled in this open-label, single-arm, single-center trial. Objective and subjective measures of sleep were prospectively assessed. Sleep disturbance, excessive sleepiness, and depressive symptoms were assessed using questionnaires.Results: A tot

Published
2024

17. Human Support Robot as Research Platform of Domestic Mobile Manipulator

Author

Yamamoto, Takashi, Takagi, Yutaro, Ochiai, Akiyoshi, Iwamoto, Kunihiro, Itozawa, Yuta, Asahara, Yoshiaki, Yokochi, Yasukata, Ikeda, Koichi, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Chalup, Stephan, editor, Niemueller, Tim, editor, Suthakorn, Jackrit, editor, and Williams, Mary-Anne, editor

Published
2019
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19. Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein

Author

Nakamura, Mariko, primary, Yoshimi, Akira, additional, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Kishi, Shinichi, additional, Miyauchi, Tomoya, additional, Iwamoto, Kunihiro, additional, Ito, Mikiko, additional, Sato-Boku, Aiji, additional, Mouri, Akihiro, additional, Nabeshima, Toshitaka, additional, Ozaki, Norio, additional, and Noda, Yukihiro, additional

Published
2024
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25. Feasibility of a wrist-worn wearable device for estimating mental health status in patients with mental illness

Author

Nakagome, Kazuyuki, primary, Makinodan, Manabu, additional, Uratani, Mitsuhiro, additional, Kato, Masaki, additional, Ozaki, Norio, additional, Miyata, Seiko, additional, Iwamoto, Kunihiro, additional, Hashimoto, Naoki, additional, Toyomaki, Atsuhito, additional, Mishima, Kazuo, additional, Ogasawara, Masaya, additional, Takeshima, Masahiro, additional, Minato, Kazumichi, additional, Fukami, Toshikazu, additional, Oba, Mari, additional, Takeda, Kazuyoshi, additional, and Oi, Hideki, additional

Published
2023
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38. A Study of Factors Causing Sleep State Misperception in Patients with Depression

Author

Kawai,Keita, Iwamoto,Kunihiro, Miyata,Seiko, Okada,Ippei, Ando,Motoo, Fujishiro,Hiroshige, Noda,Akiko, Ozaki,Norio, Kawai,Keita, Iwamoto,Kunihiro, Miyata,Seiko, Okada,Ippei, Ando,Motoo, Fujishiro,Hiroshige, Noda,Akiko, and Ozaki,Norio

Abstract

Keita Kawai,1 Kunihiro Iwamoto,1 Seiko Miyata,1 Ippei Okada,1 Motoo Ando,1 Hiroshige Fujishiro,1 Akiko Noda,2 Norio Ozaki1 1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan; 2Department of Biomedical Sciences, Chubu University Graduate School of Life and Health Sciences, Kasugai, JapanCorrespondence: Kunihiro Iwamoto, Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan, Tel +81-52-744-2282, Fax +81-52-744-2293, Email iwamoto@med.nagoya-u.ac.jpPurpose: Sleep state misperception, which is the discrepancy between subjective and objective sleep, is often observed in patients with depression. This phenomenon may delay the remission of depression. Previous studies have focused on the total sleep time (TST) misperception, with many of these studies using actigraphy. Thus, our study investigated depressed patients with the exploratory aim of clarifying factors associated with the sleep state misperception including the wake after sleep onset (WASO) misperception, with their objective sleep additionally evaluated by polysomnography (PSG).Patients and Methods: We conducted a cross-sectional study. Before undergoing overnight PSG monitoring, 40 patients with depression completed questionnaires that included the Beck Depression Inventory (BDI), Epworth sleepiness scale, Temperament and Character Inventory, and the Pittsburgh sleep quality index. Patients were also asked to estimate their subjective sleep duration after they woke up in the morning. Based on this data, we calculated the misperception using the following formula: subjective sleep duration minus objective sleep duration. We compared each factor between negative and positive misperception groups and the multiple regression analysis was performed for TST and WASO misperception, respectively.Results: Although sleep architectures, age, severity of depression and obstructive sleep apnea (OSA) exhibited differenc

Published
2022

44. Association between effect of duloxetine on chronic orofacial pain and expression of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia

Author

Mariko, Nakamura, primary, Yoshimi, Akira, additional, Mouri, Akihiro, additional, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Kishi, Shinichi, additional, Miyauchi, Tomoya, additional, Iwamoto, Kunihiro, additional, Ito, Mikiko, additional, Sato, Aiji, additional, Ozaki, Norio, additional, Nabeshima, Toshitaka, additional, and Noda, Yukihiro, additional

Published
2022
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45. Unmet needs of patients with major depressive disorder – Findings from the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ project: A nationwide dissemination, education, and evaluation study

Author

Iida, Hitoshi, Iga, Junichi, Hasegawa, Naomi, Yasuda, Yuka, Yamamoto, Tomoya, Miura, Kenichiro, Matsumoto, Junya, Murata, Atsunobu, Ogasawara, Kazuyoshi, Yamada, Hisashi, Hori, Hikaru, Ichihashi, Kayo, Hashimoto, Naoki, Ohi, Kazutaka, Yasui‐Furukori, Norio, Tsuboi, Takashi, Nakamura, Toshinori, Usami, Masahide, Furihata, Ryuji, Takaesu, Yoshikazu, Iwamoto, Kunihiro, Sugiyama, Nobuhiro, Kishimoto, Taishiro, Tsujino, Naohisa, Yamada, Hiroki, Hishimoto, Akitoyo, Nemoto, Kiyotaka, Atake, Kiyokazu, Muraoka, Hiroyuki, Katsumoto, Eiichi, Oishi, Satoru, Inagaki, Takahiko, Ito, Fumiaki, Imamura, Yayoi, Kido, Mikio, Nagasawa, Tatsuya, Numata, Shusuke, Ochi, Shinichiro, Iwata, Masaaki, Yamamori, Hidenaga, Fujita, Junichi, Onitsuka, Toshiaki, Yamamura, Satoshi, Makinodan, Manabu, Fujimoto, Michiko, Takayanagi, Yoichiro, Takezawa, Kenji, Komatsu, Hiroshi, Fukumoto, Kentaro, Tamai, Shinichiro, Yamagata, Hirotaka, Kubota, Chika, Horai, Tadasu, Inada, Ken, Watanabe, Koichiro, Kawasaki, Hiroaki, and Hashimoto, Ryota

Subjects
Letters to the Editor, Letter to the Editor
Published
2020

46. Improvement of psychiatrists’ clinical knowledge of the treatment guidelines for schizophrenia and major depressive disorders using the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ project : A nationwide dissemination, education, and evaluation study

Author

Takaesu, Yoshikazu, Watanabe, Koichiro, Numata, Shusuke, Iwata, Masaaki, Kudo, Noriko, Oishi, Satoru, Takizawa, Takeya, Nemoto, Kiyotaka, Yasuda, Yuka, Tagata, Hiromi, Tsuboi, Takashi, Tsujino, Naohisa, Hashimoto, Naoki, Matsui, Yuki, Hori, Hikaru, Yamamori, Hidenaga, Sugiyama, Nobuhiro, Suwa, Taro, Kishimoto, Taishiro, Hishimoto, Akitoyo, Usami, Masahide, Furihata, Ryuji, Iwamoto, Kunihiro, Fujishiro, Hiroshige, Nakamura, Toshinori, Mizuno, Kentaro, Inagaki, Takahiko, Katsumoto, Eiichi, Tomita, Hiroaki, Ohi, Kazutaka, Muraoka, Hiroyuki, Atake, Kiyokazu, Iida, Hitoshi, Nagasawa, Tatsuya, Fujita, Junichi, Yamamura, Satoshi, Onitsuka, Toshiaki, Murata, Atsunobu, Takayanagi, Yoichiro, Noda, Hokuto, Matsumura, Yukiko, Takezawa, Kenji, Iga, Jun‐ichi, Ichihashi, Kayo, Ogasawara, Kazuyoshi, Yamada, Hisashi, Inada, Ken, and Hashimoto, Ryota

Subjects
schizophrenia, major depressive disorder, treatment guideline, EGUIDE project, mental disorders, educational program
Abstract

Aim: Although treatment guidelines for pharmacological therapy for schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology and Mood Disorders, these guidelines have not been well applied by psychiatrists throughout the nation. To address this issue, we developed the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ integrated education programs for psychiatrists to disseminate the clinical guidelines. Additionally, we conducted a systematic efficacy evaluation of the programs. Methods: Four hundred thirteen out of 461 psychiatrists attended two 1‐day educational programs based on the treatment guidelines for schizophrenia and major depressive disorder from October 2016 to March 2018. We measured the participants’ clinical knowledge of the treatment guidelines using self‐completed questionnaires administered before and after the program to assess the effectiveness of the programs for improving knowledge. We also examined the relation between the participants’ demographics and their clinical knowledge scores. Results: The clinical knowledge scores for both guidelines were significantly improved after the program. There was no correlation between clinical knowledge and participant demographics for the program on schizophrenia; however, a weak positive correlation was found between clinical knowledge and the years of professional experience for the program on major depressive disorder. Conclusion: Our results provide evidence that educational programs on the clinical practices recommended in guidelines for schizophrenia and major depressive disorder might effectively improve participants’ clinical knowledge of the guidelines. These data are encouraging to facilitate the standardization of clinical practices for psychiatric disorders.

Published
2019

47. Temporal trajectories of proposed biomarkers in psychiatric‐onset prodromal dementia with Lewy bodies: a case report.

Author

Fujishiro, Hiroshige, Arafuka, Shusei, Ogasawara, Kazuyoshi, Iwamoto, Kunihiro, Miyata, Seiko, Torii, Youta, Iritani, Shuji, and Ozaki, Norio

Subjects
BIOMARKERS, APATHY, LEWY body dementia, AGITATION (Psychology), ACTIVITIES of daily living, MAGNETIC resonance imaging, POLYSOMNOGRAPHY, RAPID eye movement sleep, DYSPNEA, NEUROPSYCHOLOGICAL tests, DISEASE relapse, RADIONUCLIDE imaging, MENTAL depression, ATTENTION, SINGLE-photon emission computed tomography, DISEASE duration, ANOREXIA nervosa, INSOMNIA, FATIGUE (Physiology), ELECTROMYOGRAPHY, DISEASE risk factors, SYMPTOMS, OLD age
Abstract

A case study of a 69-year-old woman developed depressive mood with appetite loss, apathy, insomnia, agitation, decreased ability of concentration, fatigue, dyspnea, and thoughts of suicide, is presented. Topics include clinical profiles during two depressive episodes at hospitalization and discuss the potential predictors of higher risk of developing dementia with Lewy bodies (DLB); and dimer brain perfusion single-photon emission computed tomography showed localised occipital hypoperfusion.

Published
2023
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49. FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 years and older with Insomnia Disorder

Author

Okada, Ippei, primary, Iwamoto, Kunihiro, additional, Miyata, Seiko, additional, Fujimoto, Akihiro, additional, Tanaka, Masaki, additional, Amano, Manabu, additional, Matsuyama, Nao, additional, Taoka, Toshiaki, additional, Naganawa, Shinji, additional, and Ozaki, Norio, additional

Published
2021
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50. Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia

Author

Nakamura, Mariko, primary, Yoshimi, Akira, additional, Mouri, Akihiro, additional, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Kishi, Shinichi, additional, Miyauchi, Tomoya, additional, Iwamoto, Kunihiro, additional, Ito, Mikiko, additional, Sato‐Boku, Aiji, additional, Ozaki, Norio, additional, Nabeshima, Toshitaka, additional, and Noda, Yukihiro, additional

Published
2021
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