40 results on '"Hyub Huh"'
Search Results
2. Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia
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Hye Won Shin, Hyun Jung Kim, Yoo Kyung Jang, Hae Sun You, Hyub Huh, Yoon Ji Choi, Seung Uk Choi, and Ji Su Hong
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Anesthetic depth monitoring ,Bispectral index ,Phase lag entropy ,Propofol ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Background Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth monitoring using PLE and to evaluate the correlation between PLE and bispectral index (BIS) values during propofol anesthesia. Methods In thirty-five adult patients undergoing elective surgery, anesthesia was induced with propofol using target-controlled infusion (the Schneider model). We recorded the PLE value, raw EEG, BIS value, and hemodynamic data when the target effect-site concentration (Ce) of propofol reached 2, 3, 4, 5, and 6 μg/ml before intubation and 6, 5, 4, 3, 2 μg/ml after intubation and injection of muscle relaxant. We analyzed whether PLE and raw EEG data from the PLE monitor reflected the anesthetic depth as the Ce of propofol changed, and whether PLE values were comparable to BIS values. Results PLE values were inversely correlated to changes in propofol Ce (propofol Ce from 0 to 6.0 μg/ml, r2 = − 0.83; propofol Ce from 6.0 to 2.0 μg/ml, r2 = − 0.46). In the spectral analysis of EEG acquired from the PLE monitor, the persistence spectrogram revealed a wide distribution of power at loss of consciousness (LOC) and recovery of consciousness (ROC), with a narrow distribution during unconsciousness. The power spectrogram showed the typical pattern seen in propofol anesthesia with slow alpha frequency band oscillation. The PLE value demonstrated a strong correlation with the BIS value during the change in propofol Ce from 0 to 6.0 μg/ml (r2 = 0.84). PLE and BIS values were similar at LOC (62.3 vs. 61.8) (P > 0.05), but PLE values were smaller than BIS values at ROC (64.4 vs 75.7) (P
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- 2020
- Full Text
- View/download PDF
3. Influence of two-handed jaw thrust during tracheal intubation on postoperative sore throat: a prospective randomised study
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Hyub Huh, Doo Yeon Go, Jang Eun Cho, Jihoon Park, Jiwon Lee, and Hyun-Chang Kim
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Medicine (General) ,R5-920 - Abstract
Objective General anaesthesia with tracheal intubation results in sore throat. We evaluated the influence of the two-handed jaw thrust on postoperative sore throat in patients who require tracheal intubation. Methods In this prospective, double-blind, single-centre, parallel-arm, and randomised trial, 92 patients who were scheduled for general anaesthesia for total hip arthroplasty were allocated to one of two groups. In the jaw thrust group (n = 46), the two-handed jaw thrust manoeuvre was applied at intubation. In the control group (n = 46), conventional intubation with sham jaw thrust was performed. Incidences of airway morbidities including sore throat, hoarseness, and cough at 2, 4, and 24 hours postoperatively were compared. Results During the postoperative 24 hours, the incidence of sore throat (8 [17%] vs. 20 [44%]) and hoarseness were lower in the jaw thrust group (8 [17%] vs. 18 [39%]) compared with the control group. The incidence of cough during the postoperative 24 hours was similar between the groups. Conclusions The jaw thrust manoeuvre significantly reduced sore throat and hoarseness in patients after general anaesthesia using tracheal intubation. Clinical trial registration: NCT 03568279.
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- 2021
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4. Successful early application of extracorporeal membrane oxygenation to support cardiopulmonary resuscitation for a patient suffering from severe malignant hyperthermia and cardiac arrest: a case report
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Hyub Huh, Jae Seung Jung, Sang Jae Park, Min Kyung Park, Choon Hak Lim, and Seung Zhoo Yoon
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dantrolene ,desflurane ,extracorporeal membrane oxygenation ,malignant hyperthermia ,Anesthesiology ,RD78.3-87.3 - Abstract
Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants. MH is a rare and a potentially lethal disease, which can lead to cardiac arrest. We report a case of severe MH, in which the rapidly evolving signs of hypermetabolism eventually resulted in cardiac arrest. Despite conventional treatments following cardiopulmonary resuscitation, the patient's vital signs did not improve. Therefore, we applied extracorporeal membrane oxygenation for providing hemodynamic support.
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- 2017
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5. Anesthetic management of penetrating neck injury patient with embedded knife -A case report
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Hyub Huh, Jin Hee Han, Jun-Young Chung, Jae-Woo Yi, Bong Jae Lee, Dong Ok Kim, and Keon-Sik Kim
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fiberoptic bronchoscopy ,monitored anesthesia care ,penetrating neck injury ,tracheal injury ,Anesthesiology ,RD78.3-87.3 - Abstract
Penetrating neck injuries can be a fatal event and they are difficult to manage for both surgeons and anesthesiologists. So, adequate preoperative evaluation is important to improve the patients' outcomes, but this can not be done for hemodynamically unstable or uncooperative patient. Here we present our clinical experience with a patient with a penetrating neck injury and who was hemodynamically stable, but she was uncooperative and the knife was still embedded in her neck. The surgical exploration and bronchoscopic examination were successfully done under monitored anesthesia care.
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- 2012
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6. Automated artifact elimination of physiological signals using a deep belief network: An application for continuously measured arterial blood pressure waveforms.
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Yunsik Son 0001, Seung-Bo Lee, Hakseung Kim, Eun-Suk Song, Hyub Huh, Marek Czosnyka, and Dong-Joo Kim
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- 2018
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7. Bilateral superficial cervical plexus block for parathyroidectomy during pregnancy: A case report
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Jun-Young Chung, Yo Seob Lee, Seung Yeon Pyeon, Sang-Ah Han, and Hyub Huh
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General Medicine - Published
- 2022
8. Analysis of EEG to quantify depth of anesthesia using Hidden Markov Model.
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Junbeom Kim, Hyub Huh, Seung Zhoo Yoon, Ho-Jin Choi, Kwang Moo Kim, and Sang-Hyun Park
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- 2014
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9. Comparison between pressure-controlled and manual ventilation during anesthetic induction in patients with expected difficult airway: A prospective randomized controlled trial.
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Jeong Jun Park, Hyunyoung Seong, Hyub Huh, Ji Soo Kwak, Heechan Park, Seung Zhoo Yoon, and Jang Eun Cho
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- 2023
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10. Impact of the Deep Neuromuscular Block on Oncologic Quality of Laparoscopic Surgery in Obese Gastric Cancer Patients: A Randomized Clinical Trial
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Shin-Hoo, Park, Hyub, Huh, Sung Il, Choi, Jong-Han, Kim, You-Jin, Jang, Joong-Min, Park, Oh Kyoung, Kwon, Mi Ran, Jung, Oh, Jeong, Chang Min, Lee, Jae Seok, Min, Jin-Jo, Kim, Liang, An, Kyung Sook, Yang, Sungsoo, Park, Il Ok, Lee, and Seung Zhoo, Yoon
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Stomach Neoplasms ,Neuromuscular Blockade ,Humans ,Surgery ,Laparoscopy ,Obesity ,Rocuronium - Abstract
Obesity can hinder laparoscopic procedures and impede oncological safety during laparoscopic cancer surgery. Deep neuromuscular block (NMB) reportedly improves laparoscopic surgical conditions, but its oncological benefits are unclear. We aimed to evaluate whether deep NMB improves the oncologic quality of laparoscopic cancer surgery in obese patients.We conducted a double-blinded, parallel-group, randomized, phase 3 trial at 9 institutions in Korea. Clinical stage I and II gastric cancer patients with a BMI at or above 25 kg m -2 were eligible and randomized 1:1 ratio to the deep or moderate NMB groups, with continuous infusion of rocuronium (0.5-1.0 and 0.1-0.5 mg kg -1 h -1, respectively). The primary endpoint was the number of retrieved lymph nodes (LNs). The secondary endpoints included the surgeon's surgical rating score (SRS) and interrupted events.Between August 2017 and July 2020, 196 patients were enrolled. Fifteen patients were excluded, and 181 patients were finally included in the study. There was no significant difference in the number of retrieved LNs between the deep (N = 88) and moderate NMB groups (N = 93; 44.6 ± 17.5 vs 41.5 ± 16.9, p = 0.239). However, deep NMB enabled retrieving more LNs in patients with a BMI at or above 28 kg/m2 than moderate NMB (49.2 ± 18.6 vs 39.2 ± 13.3, p = 0.026). Interrupted events during surgery were lower in the deep NMB group than in the moderate NMB group (21.6% vs 36.6%; p = 0.034). The SRS was not influenced by NMB depth.Deep NMB provides potential oncologic benefits by retrieving more LNs in patients with BMI at or above 28 kg/m2 during laparoscopic gastrectomy.
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- 2022
11. Effectiveness Comparison of Dexmedetomidine and Remifentanil for Perioperative Management in Patients Undergoing Endoscopic Sinus Surgery
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Jang Eun Cho, Hyub Huh, Seung Zhoo Yoon, Hyun Young Seong, Sang Hag Lee, and Jeong Jun Park
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Remifentanil ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Piperidines ,Heart rate ,medicine ,Humans ,Hypnotics and Sedatives ,Immunology and Allergy ,In patient ,Dexmedetomidine ,030223 otorhinolaryngology ,Perioperative management ,business.industry ,General Medicine ,Endoscopic sinus surgery ,Epinephrine ,Otorhinolaryngology ,Anesthesia ,Nasal administration ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background For patients undergoing endoscopic sinus surgery, intranasal injection of epinephrine can cause acute increases in heart rate and blood pressure. Objective Among the drugs for reducing hyperdynamic effects, dexmedetomidine and remifentanil are expected to blunt the acute hemodynamic responses after intranasal injection of epinephrine. Our study compared a difference in the 2 drugs in their abilities to blunt the hemodynamic responses in intraoperative period and postoperative profile. Methods In this study, the patients were randomly divided into the dexmedetomidine and remifentanil groups. During the intraoperative period, the hemodynamic values were recorded. The surgical condition was assessed by a single surgeon. During the postoperative period, hemodynamic values, sedation scale score, and pain score were recorded. Result No significant differences in hemodynamic variables were found between the groups before and after intranasal injection of epinephrine. Comparison of the group mean values before endotracheal intubation revealed that the blood pressure values in the remifentanil group were significantly lower than those in the dexmedetomidine group. At 2 minutes after endotracheal intubation, blood pressure and heart rate values in the remifentanil group were significantly lower than those in the dexmedetomidine group. The sedation score was significantly lower in the dexmedetomidine group on arrival and at 30 minutes after arrival at the postanesthetic care unit ( P Conclusion Dexmedetomidine had better postoperative sedative and analgesic effects than remifentanil for patients undergoing endoscopic sinus surgery in this study. Remifentanil and dexmedetomidine attenuated acute hemodynamic responses to be within normal ranges after intranasal injection of epinephrine, and no significant differences in terms of hemodynamic variables. Remifentanil was superior to dexmedetomidine in inducing hypotension during endotracheal intubation.
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- 2020
12. The effects of two-handed jaw thrust on i-gel™ placement in anesthetized non-paralyzed patients
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Hyub Huh, Suk Woo Lee, Hyun-Chang Kim, and Jang Eun Cho
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Adult ,business.industry ,medicine.medical_treatment ,Pharyngitis ,Anesthesia, General ,Laryngeal Masks ,Confidence interval ,stomatognathic diseases ,Anesthesiology and Pain Medicine ,Insertion time ,Interquartile range ,Anesthesia ,Cuff ,Intubation, Intratracheal ,Sore throat ,Humans ,Medicine ,Intubation ,Prospective Studies ,medicine.symptom ,business ,Prospective cohort study - Abstract
BACKGROUND I-gelTM is a second-generation supraglottic airway device with a non-inflatable cuff. In this prospective randomized investigation, we evaluated the effects of two-handed jaw thrust technique on i-gel insertion in anesthetized non-paralyzed patients. METHODS Seventy-four adult patients were allocated to two groups (N.=37 each). In the jaw thrust group, two-handed jaw thrust technique was applied to facilitate i-gel insertion. In the control group, conventional i-gel insertion was performed. The success rate at the first attempt, air leakage pressure, insertion time, and postoperative sore throat incidence were recorded. RESULTS The success rate at the first attempt was higher in the jaw thrust group (37 [100%] vs. 31 [84%], difference of 16%, 95% confidence interval for the difference: 1 to 33%, P=0.03). The median air leakage pressure was higher in the jaw thrust group than in the control group (20 [interquartile range 13] vs. 17 [interquartile range 3] cmH 2 O, difference: 6, 95% confidence interval of the difference: 3 to 8, P
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- 2021
13. Influence of two-handed jaw thrust during tracheal intubation on postoperative sore throat: a prospective randomised study
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Hyun-Chang Kim, Ji-Hoon Park, Jang Eun Cho, Ji Won Lee, Doo Yeon Go, and Hyub Huh
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Prospective Clinical Research Report ,Medicine (General) ,genetic structures ,medicine.medical_treatment ,Jaw thrust ,Airway management ,Biochemistry ,intubation ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,R5-920 ,stomatognathic system ,030202 anesthesiology ,medicine ,Sore throat ,Intubation, Intratracheal ,otorhinolaryngologic diseases ,Intubation ,Humans ,In patient ,Prospective Studies ,Hoarseness ,business.industry ,Biochemistry (medical) ,Tracheal intubation ,pharyngitis ,030208 emergency & critical care medicine ,Cell Biology ,General Medicine ,anaesthesia ,Pharyngitis ,sore throat ,intratracheal ,stomatognathic diseases ,general ,Anesthesia ,medicine.symptom ,business - Abstract
ObjectiveGeneral anaesthesia with tracheal intubation results in sore throat. We evaluated the influence of the two-handed jaw thrust on postoperative sore throat in patients who require tracheal intubation.MethodsIn this prospective, double-blind, single-centre, parallel-arm, and randomised trial, 92 patients who were scheduled for general anaesthesia for total hip arthroplasty were allocated to one of two groups. In the jaw thrust group (n = 46), the two-handed jaw thrust manoeuvre was applied at intubation. In the control group (n = 46), conventional intubation with sham jaw thrust was performed. Incidences of airway morbidities including sore throat, hoarseness, and cough at 2, 4, and 24 hours postoperatively were compared.ResultsDuring the postoperative 24 hours, the incidence of sore throat (8 [17%] vs. 20 [44%]) and hoarseness were lower in the jaw thrust group (8 [17%] vs. 18 [39%]) compared with the control group. The incidence of cough during the postoperative 24 hours was similar between the groups.ConclusionsThe jaw thrust manoeuvre significantly reduced sore throat and hoarseness in patients after general anaesthesia using tracheal intubation. Clinical trial registration: NCT 03568279.
- Published
- 2021
14. sj-pdf-1-imr-10.1177_0300060520961237 - Supplemental material for Influence of two-handed jaw thrust during tracheal intubation on postoperative sore throat: a prospective randomised study
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Hyub Huh, Go, Doo Yeon, Cho, Jang Eun, Jihoon Park, Jiwon Lee, and Hyun-Chang Kim
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111199 Nutrition and Dietetics not elsewhere classified ,Cardiology ,170199 Psychology not elsewhere classified ,111799 Public Health and Health Services not elsewhere classified ,110604 Sports Medicine ,FOS: Health sciences ,110306 Endocrinology ,110308 Geriatrics and Gerontology ,111099 Nursing not elsewhere classified ,111708 Health and Community Services ,160807 Sociological Methodology and Research Methods ,111702 Aged Health Care ,111403 Paediatrics ,110904 Neurology and Neuromuscular Diseases ,110203 Respiratory Diseases ,110315 Otorhinolaryngology ,FOS: Clinical medicine ,110319 Psychiatry (incl. Psychotherapy) ,FOS: Sociology ,FOS: Psychology ,stomatognathic diseases ,110599 Dentistry not elsewhere classified ,110323 Surgery ,110305 Emergency Medicine ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,111299 Oncology and Carcinogenesis not elsewhere classified ,110314 Orthopaedics - Abstract
Supplemental material, sj-pdf-1-imr-10.1177_0300060520961237 for Influence of two-handed jaw thrust during tracheal intubation on postoperative sore throat: a prospective randomised study by Hyub Huh, Doo Yeon Go, Jang Eun Cho, Jihoon Park, Jiwon Lee and Hyun-Chang Kim in Journal of International Medical Research
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- 2021
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15. Effect of chlorpheniramine administration on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of bladder tumor: a prospective randomized study
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Jang Eun Cho, Hyun-Chang Kim, Suk Woo Lee, and Hyub Huh
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medicine.medical_specialty ,Chlorpheniramine ,Pain, Postoperative ,business.industry ,Nausea ,Incidence (epidemiology) ,medicine.medical_treatment ,Urinary Catheters ,Confidence interval ,Catheter ,Anesthesiology and Pain Medicine ,Double-Blind Method ,Urinary Bladder Neoplasms ,Anesthesia ,Anesthesiology ,Post-hoc analysis ,medicine ,Vomiting ,Humans ,Prospective Studies ,medicine.symptom ,business ,Urinary Catheterization ,Saline - Abstract
Catheter-related bladder discomfort (CRBD) is postoperative distress caused by a urinary catheter. CRBD is related to muscarinic receptor activation. Chlorpheniramine has antimuscarinic properties. Hence, this investigation was undertaken to evaluate the efficacy of chlorpheniramine in preventing CRBD in patients undergoing transurethral resection of bladder tumor (TURBT). Seventy-six patients scheduled for TURBT under general anesthesia were assigned into two groups. In the chlorpheniramine group (n = 38), 100 ml normal saline containing 0.1 mg/kg chlorpheniramine was infused after general anesthesia induction. In the control group (n = 38), 100 ml normal saline alone was infused. The incidence and severity of CRBD were assessed at 1, 6, and 24 h postoperatively. The 1-h postoperative incidence of CRBD was lower in the chlorpheniramine group based on the unadjusted analysis [16 (42%) vs. 28 (74%), risk difference 32%, 95% confidence interval 8–51, p = 0.005]. After adjusting the size of the urinary catheter, post hoc analysis showed that the 1-h postoperative incidence of CRBD was lower in the chlorpheniramine group (p = 0.004). The CRBD severity score was lower in the chlorpheniramine group at 1 and 6 h after operation based on the unadjusted analysis (p = 0.012 and p = 0.007, respectively). After adjusting the urinary catheter size, post hoc analysis showed that 1- and 6-h CRBD severity score was lower in the chlorpheniramine group (p = 0.012 and p = 0.008, respectively). The incidence of rescue medication was lower in the chlorpheniramine group [10 (26%) vs. 20 (53%), risk difference 26%, 95% confidence interval 3–47, p = 0.019]. The overall incidence of complications such as nausea, vomiting, dry mouth, flushing, dizziness, and blurred vision was comparable between the two groups. Chlorpheniramine administration significantly reduces the incidence and severity of CRBD in the patients undergoing TURBT. KCT0004880 ( https://cris.nih.go.kr/ )
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- 2020
16. Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia
- Author
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Ji Su Hong, Yoo Kyung Jang, Hye Won Shin, Hyub Huh, Hae Sun You, Seung Uk Choi, Yoon Ji Choi, and Hyun Jung Kim
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Adult ,Male ,medicine.medical_specialty ,Entropy ,medicine.medical_treatment ,Electroencephalography ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,Consciousness Monitors ,0302 clinical medicine ,030202 anesthesiology ,Anesthesiology ,Republic of Korea ,medicine ,Humans ,Intubation ,Propofol anesthesia ,Prospective Studies ,Propofol ,medicine.diagnostic_test ,business.industry ,Phase lag entropy ,Brain ,Phase lag ,Anesthetic depth monitoring ,Anesthesiology and Pain Medicine ,Bispectral index ,lcsh:Anesthesiology ,Anesthesia ,Anesthetic ,Female ,business ,Anesthetics, Intravenous ,030217 neurology & neurosurgery ,Research Article ,medicine.drug - Abstract
Background Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth monitoring using PLE and to evaluate the correlation between PLE and bispectral index (BIS) values during propofol anesthesia. Methods In thirty-five adult patients undergoing elective surgery, anesthesia was induced with propofol using target-controlled infusion (the Schneider model). We recorded the PLE value, raw EEG, BIS value, and hemodynamic data when the target effect-site concentration (Ce) of propofol reached 2, 3, 4, 5, and 6 μg/ml before intubation and 6, 5, 4, 3, 2 μg/ml after intubation and injection of muscle relaxant. We analyzed whether PLE and raw EEG data from the PLE monitor reflected the anesthetic depth as the Ce of propofol changed, and whether PLE values were comparable to BIS values. Results PLE values were inversely correlated to changes in propofol Ce (propofol Ce from 0 to 6.0 μg/ml, r2 = − 0.83; propofol Ce from 6.0 to 2.0 μg/ml, r2 = − 0.46). In the spectral analysis of EEG acquired from the PLE monitor, the persistence spectrogram revealed a wide distribution of power at loss of consciousness (LOC) and recovery of consciousness (ROC), with a narrow distribution during unconsciousness. The power spectrogram showed the typical pattern seen in propofol anesthesia with slow alpha frequency band oscillation. The PLE value demonstrated a strong correlation with the BIS value during the change in propofol Ce from 0 to 6.0 μg/ml (r2 = 0.84). PLE and BIS values were similar at LOC (62.3 vs. 61.8) (P > 0.05), but PLE values were smaller than BIS values at ROC (64.4 vs 75.7) (P Conclusions The PLE value is a useful anesthetic depth indicator, similar to the BIS value, during propofol anesthesia. Spectral analysis of EEG acquired from the PLE monitor demonstrated the typical patterns seen in propofol anesthesia. Trial registration This clinical trial was retrospectively registered at ClinicalTrials.gov at October 2017 (NCT03299621).
- Published
- 2020
17. Two-handed jaw thrust decreases postoperative sore throat in patients undergoing double-lumen endobronchial intubation: A randomised study
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Jang Eun Cho, Jeong J. Park, Doo Yeon Go, Hye Ja Lim, Jiwon Lee, Seung Zhoo Yoon, Ji-Hoon Park, Hyun Chang Kim, and Hyub Huh
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medicine.medical_specialty ,medicine.medical_treatment ,Jaw thrust ,Lumen (anatomy) ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,stomatognathic system ,030202 anesthesiology ,otorhinolaryngologic diseases ,medicine ,Sore throat ,Intubation, Intratracheal ,Intubation ,Humans ,In patient ,Postoperative Period ,business.industry ,Incidence ,Tracheal intubation ,030208 emergency & critical care medicine ,Pharyngitis ,Confidence interval ,Surgery ,stomatognathic diseases ,Anesthesiology and Pain Medicine ,Relative risk ,medicine.symptom ,business - Abstract
BACKGROUND Tracheal intubation using a double-lumen endobronchial tube (DLT) causes postoperative sore throat. OBJECTIVE To determine the effect of two-handed jaw thrust on postoperative sore throat in patients requiring insertion of a DLT. DESIGN A randomised study. SETTING A tertiary teaching hospital from December 2017 to May 2018. PATIENTS One-hundred and six patients undergoing one-lung anaesthesia. INTERVENTIONS Patients were allocated to one of two groups (n=53 each). In the jaw thrust group, the two-handed jaw thrust manoeuvre was applied at intubation and advancement of the DLT. In the control group, conventional intubation with a sham jaw thrust was performed. MAIN OUTCOME MEASURES Incidence of sore throat at 1, 6 and 24 h postoperatively. RESULTS The incidence of sore throat at 6 h postoperatively was higher in the control group than in the jaw thrust group [31 (59%) vs. 14 (26%), risk ratio (95% confidence interval) 0.45 (0.27 to 0.75), P
- Published
- 2019
18. Automated artifact elimination of physiological signals using a deep belief network: An application for continuously measured arterial blood pressure waveforms
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Hyub Huh, Marek Czosnyka, Yunsik Son, Eun Suk Song, Hakseung Kim, Seung Bo Lee, and Dong Ju Kim
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Normalization (statistics) ,Signal processing ,Artifact (error) ,Information Systems and Management ,genetic structures ,Computer science ,business.industry ,0206 medical engineering ,Pattern recognition ,02 engineering and technology ,020601 biomedical engineering ,Signal ,Computer Science Applications ,Theoretical Computer Science ,03 medical and health sciences ,Deep belief network ,0302 clinical medicine ,Artificial Intelligence ,Control and Systems Engineering ,Intensive care ,Artificial intelligence ,business ,030217 neurology & neurosurgery ,Software - Abstract
Artifacts in physiological signals acquired during intensive care have the potential to be recognized as critical pathological events and lead to misdiagnosis or mismanagement. Manual artifact removal necessitates significant labor-time intensity and is subject to inter- and intra-observer variability. Various methods have been proposed to automate the task; however, the methods are yet to be validated, possibly due to the diversity of artifact types. Deep belief networks (DBNs) have been shown to be capable of learning generative and discriminative feature extraction models, hence suitable for classifying signals with multiple features. This study proposed a DBN-based model for artifact elimination in pulse waveform signals, which incorporates pulse segmentation, pressure normalization and decision models using DBN, and applied the model to artifact removal in monitoring arterial blood pressure (ABP). When compared with a widely used ABP artifact removal algorithm (signal abnormality index; SAI), the DBN model exhibited significantly higher classification performance (net prediction of optimal DBN = 95.9%, SAI = 84.7%). In particular, DBN exhibited greater sensitivity than SAI for identifying various types of artifacts (motion = 93.6%, biological = 95.4%, cuff inflation = 89.1%, transducer flushing = 97%). The proposed model could significantly enhance the quality of signal analysis, hence may be beneficial for use in continuous patient monitoring in clinical practice.
- Published
- 2018
19. Dantrolene treatment in a patient with uncontrolled hyperthemia after general anesthesia: a case report of suspected malignant hyperthermia - A case report
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Kyung Hee Koh, Choon Hak Lim, Sung Uk Choi, Min Kyung Park, Seung Zhoo Yoon, and Hyub Huh
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03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,business.industry ,Anesthesia ,Malignant hyperthermia ,medicine ,030212 general & internal medicine ,General Medicine ,medicine.disease ,business ,Dantrolene ,medicine.drug - Published
- 2018
20. Optimal dose of rocuronium bromide undergoing adenotonsillectomy under 5% sevoflurane with fentanyl
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Jang Eun Cho, Seung Zhoo Yoon, Tae Hoon Kim, Ji Yeong Kim, Hye-Ja Lim, Hye Won Shin, Jeong Jun Park, Hye Won Lee, and Hyub Huh
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Male ,Methyl Ethers ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Sevoflurane ,Fentanyl ,Adenoidectomy ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,Intubation, Intratracheal ,medicine ,Humans ,Intubation ,General anaesthesia ,Androstanols ,Postoperative Period ,Rocuronium ,Child ,Propofol ,Tonsillectomy ,Rocuronium Bromide ,business.industry ,Tracheal intubation ,030208 emergency & critical care medicine ,General Medicine ,Surgery ,Otorhinolaryngology ,Child, Preschool ,Anesthesia ,Anesthetics, Inhalation ,Pediatrics, Perinatology and Child Health ,Airway Extubation ,Female ,business ,Anesthetics, Intravenous ,Neuromuscular Nondepolarizing Agents ,medicine.drug - Abstract
Adenotonsillectomy is a short surgical procedure under general anaesthesia in children. An ideal muscle relaxant for adenotonsillectomy would create an intense neuromuscular block while having a quick recovery time without postoperative morbidity. We compared the effect of different doses of rocuronium for the tracheal intubation in children under 5% sevoflurane and fentanyl.75 children (aged 3-10 years, ASA I) scheduled for adenotonsillectomy were enrolled. Anaesthesia was induced with propofol 2.5 mg/kg, followed by fentanyl 2 μg/kg. After mask ventilation with 5 vol% sevoflurane in 100% oxygen for 2 min, 2 ml of study drug was administered intravenously, i.e., either normal saline (S Group) or one of two doses (0.15 or 0.3 mg/kg) of rocuronium. We assessed conditions during tracheal intubation and also recorded the surgical condition, the time from discontinuation of sevoflurane to extubation and PAED scale, pain scores in PACU.Rocuronium groups (96% and 100%, respectively; P 0.01) showed statistically superior clinically acceptable intubating conditions than the saline group (72%). The 0.3 mg/kg rocuronium (80%) treatment clearly resulted in excellent intubating conditions compared with the 0.15 mg/kg group (44%; p = 0.028). There was no significant difference in the time to extubation and surgical condition, and in the postoperative measures of emergence delirium, pain, and recovery time among the three groups.A dose of 0.3 mg/kg rocuronium may provide optimal intubating conditions without delayed recovery in 5% sevoflurane anaesthesia with fentanyl in children undergoing adenotonsillectomy.NCT02467595.
- Published
- 2017
21. Reply to: two-handed jaw thrust in patients undergoing intubation with a double-lumen endobronchial tube
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Hyun-Chang Kim, Hyub Huh, Hye-Ja Lim, and Seung Zhoo Yoon
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medicine.medical_specialty ,Anesthesiology and Pain Medicine ,business.industry ,medicine.medical_treatment ,Jaw thrust ,Medicine ,Intubation ,In patient ,business ,Double-lumen endobronchial tube ,Surgery - Published
- 2021
22. Chlorhexidine and silver sulfadiazine coating on central venous catheters is not sufficient for protection against catheter-related infection: Simulation-based laboratory research with clinical validation
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Hyub Huh, Yoon Ji Choi, Chang-Hoon Gong, Jae Kwan Lim, Dong-Joo Kim, Seung Zhoo Yoon, and Jeong Jun Park
- Subjects
0301 basic medicine ,Staphylococcus aureus ,medicine.medical_specialty ,medicine.medical_treatment ,030106 microbiology ,engineering.material ,Silver sulfadiazine ,medicine.disease_cause ,Biochemistry ,Silver nanoparticle ,03 medical and health sciences ,central line infections ,0302 clinical medicine ,Coating ,otorhinolaryngologic diseases ,medicine ,Central Venous Catheters ,Humans ,030212 general & internal medicine ,bloodstream model ,Laboratory research ,Saline ,business.industry ,Chlorhexidine ,Biochemistry (medical) ,Spectrometry, X-Ray Emission ,Research Reports ,Cell Biology ,General Medicine ,Silver Sulfadiazine ,Catheter-Related Infections ,Surgery ,Anesthesia ,Anti-Infective Agents, Local ,engineering ,Antibacterial activity ,business ,medicine.drug - Abstract
Objective The efficacy of chlorhexidine- and silver sulfadiazine-coated central venous catheters (CSS-CVC) against catheter-related infection remains controversial. We hypothesized that the loss of silver nanoparticles may reduce the antibacterial efficacy of CSS-CVCs and that this loss could be due to the frictional force between the surface of the CVC and the bloodstream. The objective of this study was to investigate whether the antimicrobial effect of CSS-CVCs decreases with increasing exposure time in a bloodstream model and quantitatively assay the antimicrobial effect of CSS-CVCs compared with polyurethane and antiseptic-impregnated CVCs. Methods Each CVC was subjected to 120 hours of saline flow and analyzed at intervals over 24 hours. The analyses included energy-dispersive X-ray spectroscopy, scanning electron microscopy, and optical density after a Staphylococcus aureus incubation test. Results The weight percentage of silver in the CSS-CVCs significantly decreased to 56.18% (44.10% ± 3.32%) with 48-hour catheterization and to 18.88% (14.82% ± 1.33%) with 120-hour catheterization compared with the initial weight percentage (78.50% ± 6.32%). In the S. aureus incubation test, the antibacterial function of CSS-CVCs was lost after 48 hours [3 (N/D) of OD]. Similar results were observed in a pilot clinical study using 18 CSS-CVCs. Conclusions We found that the efficacy of CSS-CVCs decreased over time and that the antibacterial function was lost after 48 hours of simulated wear-out. Therefore, antibiotic-impregnated CVCs may be a better option when longer (>48 hours) indwelling is needed.
- Published
- 2017
23. Comparison of oncological benefits of deep neuromuscular block in obese patients with gastric cancer (DEBLOQS_GC study): A study protocol for a double-blind, randomized controlled trial
- Author
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Joong-Min Park, Dal Ah Kim, Donghwan Ha, Il Ok Lee, Hyub Huh, Liang An, Yeon Hee Kim, Jae Seok Min, Sungsoo Park, Sung Il Choi, Jin Jo Kim, Eun Jin Kim, Mi Ran Jung, Kyung Hwa Kwak, You Jin Jang, Yong Hoon Jung, Jae Woo Yi, Hong Bum Bae, Jong Han Kim, Oh Kyoung Kwon, Young Jae Mok, Yoontaek Lee, Seong Heum Park, Oh Jeong, and Chang Min Lee
- Subjects
Adult ,medicine.medical_treatment ,Sugammadex ,law.invention ,Double blind ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Randomized controlled trial ,Double-Blind Method ,Study Protocol Clinical Trial ,030202 anesthesiology ,law ,Gastrectomy ,Stomach Neoplasms ,Medicine ,Humans ,gastric neoplasm ,Obesity ,Laparoscopy ,Aged ,Neoplasm Staging ,medicine.diagnostic_test ,business.industry ,Patient Selection ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Muscle relaxation ,Treatment Outcome ,030220 oncology & carcinogenesis ,Anesthesia ,lymphadenectomy ,neuromuscular block ,Neuromuscular Blockade ,Lymphadenectomy ,Erratum ,business ,Research Article ,medicine.drug - Abstract
Purpose: Many studies have demonstrated the advantage of maintaining intraoperative deep neuromuscular block (NMB) with sugammadex. This trial is designed to evaluate the impact of muscle relaxation during laparoscopic subtotal gastrectomy on the oncological benefits, particularly in obese patients with gastric cancer. Materials and methods: This is a double-blind, randomized controlled multicenter prospective trial. Patients with clinical stage I–II gastric cancer with a body mass index of 25 and over, who undergo laparoscopic subtotal gastrectomy will be eligible for trial inclusion. The patients will be randomized into a deep NMB group or a moderate NMB group with a 1:1 ratio. A total of 196 patients (98 per group) are required. The primary endpoint is the number of harvested lymph nodes, which is a critical index of the quality of surgery in gastric cancer treatment. The secondary endpoints are surgeon's surgical condition score, patient's sedation score, and surgical outcomes including peak inspiratory pressure, operation time, postoperative pain, and morbidity. Discussion: This is the first study that compares deep NMB with moderate NMB during laparoscopic gastrectomy in obese patients with gastric cancer. We hope to show the oncologic benefits of deep NMB compared with moderate NMB during subtotal gastrectomy. Trial registration number: ClinicalTrials.gov (NCT03196791), date of registration: October 10, 2017.
- Published
- 2018
24. Effects of blood flow on the antibacterial efficacy of chlorhexidine and silver sulfadiazine coated central venous catheter
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Eung Hwi Kim, Hyun Young Seong, Yong Huan Cui, Hyub Huh, Seung Zhoo Yoon, Joon Ho Yu, Yoon Ji Choi, and Sung Uk Choi
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business.industry ,medicine.medical_treatment ,Chlorhexidine ,General Medicine ,Blood flow ,Antibacterial efficacy ,equipment and supplies ,Silver sulfadiazine ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Staphylococcus aureus ,030220 oncology & carcinogenesis ,Anesthesia ,medicine ,030212 general & internal medicine ,business ,Catheter placement ,Simulation based ,Central venous catheter ,medicine.drug - Abstract
BACKGROUND Chlorhexidine and silver sulfadiazine coated central venous catheters (CSS-CVC) may cause loss of antimicrobial efficacy due to friction between the CVC surface and sheer stress caused by the blood flow. Therefore, the aim of this study was to investigate the antibacterial efficacy of CSS-CVC at various flow rates using a bloodstream model. METHODS Each CVC was subjected to various flow rates (0.5, 1, 2, and 4 L/min) and wear-out times (0, 24, 48, 72, 96, and 120 hours), and the optical density (OD) 600 after a Staphylococcus aureus incubation test was used to determine the antibacterial effect of CSS-CVC. RESULTS In the 0.5 L/min group, there was no significant change in the OD600 value up to 120 hours compared with the baseline OD600 value for CSS-CVC (P > .467). However, the OD600 values of CSS-CVC in the 1 L/min (P
- Published
- 2020
25. Quantifying the depth of anesthesia based on brain activity signal modeling
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Joon Ho Yu, Jang Eun Cho, Jun Beom Kim, Mee Ju Lee, Sang-Hyun Park, Jisu Hong, Hyub Huh, Hye Won Lee, Kyung Sook Yang, Choon Hak Lim, and Seung Zhoo Yoon
- Subjects
Adult ,Male ,genetic structures ,Brain activity and meditation ,Observational Study ,anesthesia ,Electroencephalography ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,anesthetic depth ,bispectral index ,Humans ,Medicine ,Waveform ,cortical activity index ,030212 general & internal medicine ,Semiparametric regression ,Anesthetics ,Cerebral Cortex ,medicine.diagnostic_test ,business.industry ,spectral entropy ,Pattern recognition ,General Medicine ,electroencephalogram ,Middle Aged ,Pearson product-moment correlation coefficient ,Cholecystectomy, Laparoscopic ,Signal modeling ,030220 oncology & carcinogenesis ,Bispectral index ,symbols ,Female ,sense organs ,Artificial intelligence ,business ,Algorithms ,Depth of anesthesia ,Research Article - Abstract
Various methods of assessing the depth of anesthesia (DoA) and reducing intraoperative awareness during general anesthesia have been extensively studied in anesthesiology. However, most of the DoA monitors do not include brain activity signal modeling. Here, we propose a new algorithm termed the cortical activity index (CAI) based on the brain activity signals. In this study, we enrolled 32 patients who underwent laparoscopic cholecystectomy. Raw electroencephalography (EEG) signals were acquired at a sampling rate of 128 Hz using BIS-VISTATM with standard bispectral index (BIS) sensors. All data were stored on a computer for further analysis. The similarities and difference among spectral entropy, the BIS, and CAI were analyzed. Pearson correlation coefficient between the BIS and CAI was 0.825. The result of fitting the semiparametric regression models is the method CAI estimate (−0.00995; P = .0341). It is the estimated difference in the mean of the dependent variable between method BIS and CAI. The CAI algorithm, a simple and intuitive algorithm based on brain activity signal modeling, suggests an intrinsic relationship between the DoA and the EEG waveform. We suggest that the CAI algorithm might be used to quantify the DoA.
- Published
- 2020
26. Effect of varying external pneumatic pressure on hemolysis and red blood cell elongation index in fresh and aged blood: Randomized laboratory research
- Author
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Go Eun Bae, Seung Zhoo Yoon, Sang-Hyun Park, Hyub Huh, Yoon Ji Choi, Hye Won Shin, Choon Hak Lim, Hye Won Lee, Eun Ji Ko, and Sung Uk Choi
- Subjects
Erythrocyte Indices ,Erythrocytes ,030204 cardiovascular system & hematology ,Hemolysis ,External pressure ,Andrology ,03 medical and health sciences ,pressure ,0302 clinical medicine ,030202 anesthesiology ,blood ,Erythrocyte Deformability ,Medicine ,Humans ,Laboratory research ,transfusion ,business.industry ,elongation indices ,Pneumatic pressure ,General Medicine ,Venous blood ,Clinical Trial/Experimental Study ,medicine.disease ,Decreased rbc ,Healthy Volunteers ,Red blood cell ,medicine.anatomical_structure ,Stress, Mechanical ,Elongation ,business ,Erythrocyte Transfusion ,Research Article ,red blood cells - Abstract
Background: External applied pneumatic pressure is usually used for rapid transfusion of red blood cells (RBCs). However, increased shear stress can cause increased hemolysis and decreased RBC elongation indices. Therefore, the purpose of this study was to measure the degree of hemolysis and the alteration of RBC elongation indices under varying external pressure in fresh and aged blood. Methods: Venous blood samples were obtained from 20 healthy human volunteers. Each blood bag was divided into 2 subgroups (5 or 35 days of storage), and 5 levels of pressure were applied: 0, 150, 200, 250, and 300 mmHg. After infusion, a laboratory study was conducted. The percentages of irreversibly changed cells were evaluated using Bessis classification. RBC elongation indices were measured using a microfluidic ektacytometer. Results: There were no significant differences in the percentage of irreversibly changed RBCs between the pressures of 0 and 300 mmHg. Moreover, there were no significant differences in laboratory test results or elongation indices among all levels of pressure. Irreversibly changed RBCs and hemolysis were increased depending on the storage period. Conclusion: Irreversible changes in RBCs did not occur as a result of external pressure. The hemolysis and elongation indices of fresh RBCs were not influenced by external pneumatic pressure up to 300 mmHg. Only the storage period affected the irreversible changes in RBCs and hemolysis. Therefore, the application of external pressure to RBCs in variously aged blood is likely to be a safe procedure.
- Published
- 2018
27. A Novel and Simple Method for Tracheal Intubation in a Swine Model: Preparing for the Era of Xenotransplantation
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Hyub, Huh, Hyong Hwan, Lim, Ji Yeong, Kim, Hye Won, Shin, Hae Ja, Lim, Suk Min, Yoon, Seung Zhoo, Yoon, and Hye Won, Lee
- Subjects
Male ,Time Factors ,Vecuronium Bromide ,Sus scrofa ,Transplantation, Heterologous ,Anesthesia, General ,Laryngeal Masks ,Injections, Intravenous ,Models, Animal ,Intubation, Intratracheal ,Animals ,Female ,Neuromuscular Blocking Agents ,Learning Curve - Abstract
Organ transplant in humans is an established therapy for a variety of end-stage organ diseases. However, due to organ shortages and lack of donors, the need for xenotransplant has gradually increased. Xenotransplantation has great potential to solve many of the problems facing organ transplantation. Pigs are being developed as xenogeneic organ donors for use in humans. In this study, we propose a novel and simple method for tracheal intubation in a swine model using neuromuscular blocking agents and laryngeal mask airway.Eight Yorkshire pigs were used for the 2 separate experiments, which were conducted 1 week apart. In the first experiment, an anesthesiologist with no previous comparable experience performed endotracheal intubation of pigs. One week later, using the same pig, a second experiment was performed by an experienced anesthesiologist. Anesthesia was induced with intramuscular injection of a mixture of 1 mg/kg xylazine (Rompun, Bayer Korea Ltd., Seoul, Korea) and 7 mg/kg Zoletil (a mixture of tiletamine hydrochloride and zolazepam hydro-chloride, Virbac Laboratory, Carros, France). The laryngeal mask was then placed, and 0.15 mg/kg vecuronium bromide was injected intravenously. Tracheal intubation was attempted after mask removal. The duration and number of intubation attempts were recorded, and the degree of intubation difficulty was scored.In all cases, the laryngeal mask was easily inserted, and endotracheal intubation was successfully completed. Oxygen saturation did not fall below 95%, and there were no hypoxemia episodes. Degree of intubation difficulty and duration were not significantly different between the 2 anesthesiologists.Tracheal intubation in our swine model was successfully performed using neuromuscular blocking agents and laryngeal masks without resulting in hypoxemia, with even anesthesiologists who are unfamiliar with endotracheal intubation of pigs easily able to do so using our protocol. Therefore, our protocol will enable all investigators to perform successful tracheal intubation in swine models.
- Published
- 2017
28. The effect of fresh gas flow rate and type of anesthesia machine on time to reach target sevoflurane concentration
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Hye Won Shin, Hyub Huh, Ji Yong Park, Hae Na Yu, Go Eun Bae, and Ji Young Kim
- Subjects
Methyl Ethers ,Time Factors ,In Vitro Techniques ,Sevoflurane ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Inhalation anesthetics ,030202 anesthesiology ,law ,medicine ,Lung ,Anesthesia machines ,Fresh gas flow rate ,business.industry ,Ventilation ,Fresh gas flow ,Anesthesiology and Pain Medicine ,Volume (thermodynamics) ,Anesthesia ,Anesthetic ,Ventilation (architecture) ,Equipment design ,Vaporizer ,business ,Anesthesia, Inhalation ,030217 neurology & neurosurgery ,medicine.drug ,Research Article - Abstract
Background Anesthesia machines have been developed by the application of new technology for rapid and easier control of anesthetic concentration. In this study, we used a test lung to investigate whether the time taken to reach the target sevoflurane concentration varies with the rate of fresh gas flow (FGF) and type of anesthesia machine (AM). Methods We measured the times taken to reach the target sevoflurane concentration (2 minimum alveolar concentration = 4%) at variable rates of FGF (0.5, 1, or 3 L/min) and different types of AM (Primus®, Perseus®, and Zeus® [Zeus®-F; Zeus® fresh gas mode, Zeus®-A; Zeus® auto-mode]). Concomitant ventilation was supplied using 100% O2. The AMs were connected to a test lung. A sevoflurane vaporizer setting of 6% was used in Primus®, Perseus®, and Zeus®-F; a target end-tidal setting of 4% was used in Zeus®-A (from a vaporizer setting of 0%). The time taken to reach the target concentration was measured in every group. Results When the same AM was used (Primus®, Perseus®, or Zeus®-F), the times to target concentration shortened as the FGF rate increased (P
- Published
- 2017
29. Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency
- Author
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Na Young Kim, Hyub Huh, Jang Eun Cho, and Seol Ju Park
- Subjects
Male ,medicine.medical_specialty ,Laparoscopic radical prostatectomy ,medicine.medical_treatment ,Nicardipine ,Renal function ,Kidney ,Kidney Function Tests ,Biochemistry ,Pneumoperitoneum ,medicine ,Humans ,In patient ,Prospective Studies ,Renal Insufficiency ,Antihypertensive Agents ,Aged ,Aged, 80 and over ,Prostatectomy ,business.industry ,Biochemistry (medical) ,Prostate ,Robotics ,Cell Biology ,General Medicine ,Middle Aged ,Calcium Channel Blockers ,Surgery ,Creatinine ,Robot assisted laparoscopic radical prostatectomy ,Laparoscopy ,business ,Glomerular Filtration Rate ,medicine.drug - Abstract
Objective To investigate the renoprotective effect of nicardipine in patients with pre-existing renal insufficiency undergoing robot-assisted laparoscopic radical prostatectomy (RALRP). Methods Men with preoperative renal insufficiency (estimated glomerular filtration rate [eGFR] 2) were enrolled and randomized to receive either 0.5 µg/kg per min nicardipine continuous infusion (nicardipine group) or normal saline (control group) during RALRP. Renal function was determined by eGFR and serum creatinine concentration. Results Serum creatinine levels on postoperative days (POD) 1 and 3 were significantly lower than baseline values in the nicardipine group ( n = 50). In the control group ( n = 50), eGFR was significantly higher on POD 3 than baseline, and was significantly higher than baseline on POD 1 and 3 in the nicardipine group. The change in eGFR from baseline to POD 1 was significantly higher in the nicardipine group than the control group. Conclusion Continuous infusion of nicardipine during RALRP improved postoperative renal function on POD 1 in patients with pre-existing renal insufficiency.
- Published
- 2014
30. Effects of blood flow on the antibacterial efficacy of chlorhexidine and silver sulfadiazine coated central venous catheter: A simulation-based pilot study.
- Author
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Yong Huan Cui, Yoon Ji Choi, Eung Hwi Kim, Joon Ho Yu, Hyun Young Seong, Sung-uk Choi, Seung Zhoo Yoon, Hyub Huh, Cui, Yong Huan, Choi, Yoon Ji, Kim, Eung Hwi, Yu, Joon Ho, Seong, Hyun Young, Choi, Sung-Uk, Yoon, Seung Zhoo, and Huh, Hyub
- Published
- 2020
- Full Text
- View/download PDF
31. Quantifying the depth of anesthesia based on brain activity signal modeling.
- Author
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Hyub Huh, Sang-Hyun Park, Joon Ho Yu, Jisu Hong, Mee Ju Lee, Jang Eun Cho, Choon Hak Lim, Hye Won Lee, Jun Beom Kim, Kyung-Sook Yang, Seung Zhoo Yoon, Huh, Hyub, Park, Sang-Hyun, Yu, Joon Ho, Hong, Jisu, Lee, Mee Ju, Cho, Jang Eun, Lim, Choon Hak, Lee, Hye Won, and Kim, Jun Beom
- Published
- 2020
- Full Text
- View/download PDF
32. Successful early application of extracorporeal membrane oxygenation to support cardiopulmonary resuscitation for a patient suffering from severe malignant hyperthermia and cardiac arrest: a case report
- Author
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Hyub Huh, Jae Seung Jung, Sang Jae Park, Seung Zhoo Yoon, Choon Hak Lim, and Min Kyung Park
- Subjects
medicine.medical_treatment ,Vital signs ,Case Report ,030204 cardiovascular system & hematology ,Dantrolene ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,Desflurane ,Malignant hyperthermia ,0302 clinical medicine ,030202 anesthesiology ,medicine ,Extracorporeal membrane oxygenation ,Cardiopulmonary resuscitation ,business.industry ,Skeletal muscle ,medicine.disease ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,lcsh:Anesthesiology ,Anesthesia ,Hypermetabolism ,business ,medicine.drug - Abstract
Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants. MH is a rare and a potentially lethal disease, which can lead to cardiac arrest. We report a case of severe MH, in which the rapidly evolving signs of hypermetabolism eventually resulted in cardiac arrest. Despite conventional treatments following cardiopulmonary resuscitation, the patient's vital signs did not improve. Therefore, we applied extracorporeal membrane oxygenation for providing hemodynamic support.
- Published
- 2016
33. Composition of the Extracellular Matrix of Lymphatic Novel Threadlike Structures: Is It Keratin?
- Author
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Soo Jae Lee, Byung Cheon Lee, Sang-Hyun Park, Seung Zhoo Yoon, Ji Woong Yoon, Hyub Huh, and Eun Jung Cho
- Subjects
chemistry.chemical_classification ,Pathology ,medicine.medical_specialty ,education.field_of_study ,Article Subject ,Acridine orange ,lcsh:Other systems of medicine ,Soluble adenylyl cyclase ,lcsh:RZ201-999 ,Molecular biology ,Staining ,Extracellular matrix ,Cytokeratin ,chemistry.chemical_compound ,Lymphatic system ,Complementary and alternative medicine ,chemistry ,Keratin ,medicine ,Lymph ,education ,Research Article - Abstract
Background. The lumen of novel threadlike structures (NTSs) is enclosed by a single layer of endothelial cells surrounded by extracellular matrix (ECM). We hypothesized that collagen may be a component of the ECM associated with lymphatic NTSs.Methods. Six female New Zealand white rabbits were anesthetized, and the NTS structures within lymphatic vessels were identified by contrast-enhanced stereomicroscopy or alcian blue staining. Isolated NTS specimens were stained with acridine orange, YOYO-1, and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI). The structural and molecular composition of the ECM was investigated using transmission electron microscopy (TEM), electrospray ionization-mass spectrometry, and proteomic analysis.Results. The lymph vessel wall was stained red by DiI, and rod-shaped nuclei were stained green by YOYO-1. The area surrounding the NTS was also stained red and contained green rod-shaped nuclei. TEM images showed that the NTS consisted of many ECM fibers and the ECM fibers appeared to be ~100 nm in diameter and had narrowly spaced striated bands. Proteomic analysis of the lymphatic NTS-associated ECM identified 4 proteins: keratin 10, cytokeratin 3, cytokeratin 12, and soluble adenylyl cyclase.Conclusion. The TEM study suggested that the lymphatic NTS-associated ECM did not contain collagen. This was confirmed by proteomic analysis, which showed that keratin was the major component of the ECM.
- Published
- 2013
34. Effect of varying external pneumatic pressure on hemolysis and red blood cell elongation index in fresh and aged blood: Randomized laboratory research.
- Author
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Yoon Ji Choi, Hyub Huh, Go Eun Bae, Eun Ji Ko, Sung-uk Choi, Sang-Hyun Park, Choon Hak Lim, Hye Won Shin, Hye-won Lee, and Seung Zhoo Yoon
- Published
- 2018
- Full Text
- View/download PDF
35. Chlorhexidine and silver sulfadiazine coating on central venous catheters is not sufficient for protection against catheter-related infection: Simulation-based laboratory research with clinical validation.
- Author
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Yoon Ji Choi, Jae Kwan Lim, Jeong Jun Park, Hyub Huh, Dong-Joo Kim, Chang-Hoon Gong, and Seung Zhoo Yoon
- Published
- 2017
- Full Text
- View/download PDF
36. Analysis of EEG to quantify depth of anesthesia using Hidden Markov Model.
- Author
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Kim, Junbeom, Hyub, Huh, Yoon, Seung Zhoo, Choi, Ho-Jin, Kim, Kwang Moo, and Park, Sang-Hyun
- Published
- 2014
- Full Text
- View/download PDF
37. Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency.
- Author
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Hyub Huh, Na Young Kim, Seol Ju Park, and Jang Eun Cho
- Published
- 2014
- Full Text
- View/download PDF
38. Composition of the Extracellular Matrix of Lymphatic Novel Threadlike Structures: Is It Keratin?
- Author
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Hyub Huh, Byung-Cheon Lee, Sang-Hyun Park, Ji Woong Yoon, Soo Jae Lee, Eun Jung Cho, and Seung Zhoo Yoon
- Subjects
- *
LYMPH node physiology , *ANIMAL experimentation , *BIOLOGICAL models , *ELECTRON microscopy , *EXTRACELLULAR space , *KERATINOCYTES , *RABBITS , *RESEARCH funding , *STAINS & staining (Microscopy) - Abstract
Background. The lumen of novel threadlike structures (NTSs) is enclosed by a single layer of endothelial cells surrounded by extracellular matrix (ECM). We hypothesized that collagen may be a component of the ECM associated with lymphatic NTSs. Methods. Six female New Zealand white rabbits were anesthetized, and the NTS structures within lymphatic vessels were identified by contrast-enhanced stereomicroscopy or alcian blue staining. Isolated NTS specimens were stained with acridine orange, YOYO-1, and 1,1 -dioctadecyl-3,3,3' ,3' -tetramethylindocarbocyanine Perchlorate (Dil). The structural and molecular composition of the ECM was investigated using transmission electron microscopy (TEM), electrospray ionization-mass spectrometry, and proteomic analysis. Results. The lymph vessel wall was stained red by Dil, and rod-shaped nuclei were stained green by YOYO-1. The area surrounding the NTS was also stained red and contained green rod-shaped nuclei. TEM images showed that the NTS consisted of many ECM fibers and the ECM fibers appeared to be -100 nm in diameter and had narrowly spaced striated bands. Proteomic analysis of the lymphatic NTS-associated ECM identified 4 proteins: keratin 10, cytokeratin 3, cytokeratin 12, and soluble adenylyl cyclase. Conclusion. The TEM study suggested that the lymphatic NTS-associated ECM did not contain collagen. This was confirmed by proteomic analysis, which showed that keratin was the major component of the ECM. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
39. The Effect of Various External Pressure on Blood (EPB)
- Author
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Hyub Huh, M.D.
- Published
- 2015
40. Analysis of EEG to quantify depth of anesthesia using Hidden Markov Model.
- Author
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Kim J, Hyub H, Yoon SZ, Choi HJ, Kim KM, and Park SH
- Subjects
- Adult, Anesthesia, Humans, Intraoperative Neurophysiological Monitoring methods, Markov Chains, Middle Aged, Electroencephalography methods, Signal Processing, Computer-Assisted
- Abstract
Real-time quantification of the patient's consciousness level during anesthesia is an important issue to avoid intraoperative awareness and post-operative side effects. A depth-of-anesthesia (DoA) monitoring method called Bispectral Index (BIS) is generally used for this purpose. However, BIS is known to be inaccurate at the transitory state, and also shows a critical time delay in quantifying the patient's consciousness level. This paper introduces a novel method to reduce the response time in the quantification process. This thesis develops a new index called HDoA by analyzing EEG using Hidden Markov Model. The proposed approach is composed by two steps, training and testing. In the training step, two HMM, awakened and anesthetized model are learned based on each training set. In the testing step, by evaluating the probability of producing the testing EEG from two models respectively, the index HDoA is derived. Since the evaluation of DoA using HMM is training based method, it have better performance with more training process. Experiments show that HDoA has a high correlation with BIS at a steady state, and outperforms BIS in two ways: (1) shorter delay time in transition state, and (2) higher Fisher Score. The validity of HDoA has been tested by 8 real clinical data.
- Published
- 2014
- Full Text
- View/download PDF
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