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Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma characterized by distinct subtypes and heterogeneous treatment outcomes. Oxidative stress and the dysregulation of related regulatory genes are prevalent in DLBCL, prompting an investigation into the nuclear factor erythroid 2-related factor 2 (Nrf2)-kelch-like ECH-associated protein 1 (Keap1) signaling pathway and associated genes. The present study assessed pathological specimens and clinical data from 43 newly diagnosed patients with DLBCL, comparing the associations and correlations between the expression of Nrf2, Keap1, microtubule-associated protein 1 light chain 3β (LC3B) and nitrotyrosine and the activated B-cell (ABC) and germinal center B-cell (GCB) subtypes of DLBCL using immunohistochemistry and digital image analysis software. Nuclear Nrf2 activation was observed in 33.3% of patients with DLBCL ABC, demonstrating a higher prevalence of hepatitis B surface antigen positivity, calcium ions and significant body weight loss (P<0.05). Total Nrf2 expression was associated with the DLBCL GCB subtype and inversely correlated with Keap1 expression in the DLBCL ABC subtype. Furthermore, a positive correlation was demonstrated between Nrf2 and LC3, indicating that total Nrf2 is inhibited by Keap1 and regulates LC3 expression. The ABC subtype was also associated with lower white blood cell counts and more frequent chemotherapy courses than the GCB subtype. These findings suggest that nuclear Nrf2 could be a biomarker for DLBCL clinical diagnosis. [ABSTRACT FROM AUTHOR]

The purpose of this study was to explore the information literacy and its related factors of clinical nurses. It's a cross-sectional study design. Using the web survey, the sample of 384 clinical nurses was obtained from 754 eligible subjects who work in one of medical center located in south part of Taiwan. Data collection was using an investigator-developed structural questionnaire. Data analysis methods include independent t-test, one-way ANOVA, Sperman, Person and the multiple regressions. The outcome showed: (1) the average score of information literacy was 184. The information literacy composed 3 dimensions; the average score from high to low by order was information attitude, computer literacy, and internet literacy. (2) Information literacy and subject's age, marriage, educations, total years of nursing service, years of working with the hospital, length of the staying with the unit, clinical ladder, network, resources, login time to the XMS website, frequencies, time to use computer each week, time to accesses the net each week, studying courses, studying time were significant correlated. (3) The frequencies of use computer can contributes to 30.3% variations, is the number one predictor. According to this study findings, Informatics related curriculums should be designed systematically and integrity at on job training in service education. Increasing the application of web survey technology was discussed. [ABSTRACT FROM AUTHOR]