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Your search keyword '"Huang, Ying-Zu"' showing total 397 results
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397 results on '"Huang, Ying-Zu"'

1. Changes in TMS Measures Induced by Repetitive TMS

Author

Classen, Joseph, Huang, Ying-Zu, Zrenner, Christoph, Wassermann, Eric M., book editor, Peterchev, Angel V., book editor, Ziemann, Ulf, book editor, Lisanby, Sarah H., book editor, Siebner, Hartwig R., book editor, and Walsh, Vincent, book editor

Published
2024
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2. Intermittent Theta Burst Stimulation over the Posterior Superior Temporal Sulcus for Children with Autism Spectrum Disorder: A 4-Week Randomized Blinded Controlled Trial Followed by Another 4-Week Open-Label Intervention

Author

Ni, Hsing-Chang, Chen, Yi-Lung, Chao, Yi-Ping, Wu, Chen-Te, Wu, Yu-Yu, Liang, Sophie Hsin-Yi, Chin, Wei-Chih, Chou, Tai-Li, Gau, Susan Shur-Fen, Huang, Ying-Zu, and Lin, Hsiang-Yuan

Abstract

The posterior superior temporal sulcus is a potential therapeutic target of brain stimulation for autism spectrum disorder. We conducted a 4-week randomized, single-blind parallel sham-controlled trial, followed by additional 4-week open-label intervention to evaluate the feasibility and efficacy regarding intermittent theta burst stimulation over the bilateral posterior superior temporal sulcus in autism spectrum disorder. In total, 78 intellectually able children and adolescents were randomized to the active (n = 40) and sham groups (n = 38). During the first 4 weeks, the active group received two-session/week intermittent theta burst stimulation, whereas the sham group received the same number of sham stimulation. After unblinding, both groups received eight-session real stimulation over the additional 4 weeks. In total, 91% participants completed the protocol with mild and transitory side-effects. There was no significant group-by-time interaction for active versus sham group on clinical symptoms and social cognitive performances in the first 4 weeks. The within-group analysis revealed 8 weeks (including a 4-week blind trial and a 4-week open-label intervention) of intermittent theta burst stimulation achieved greater efficacy than 4-week interventions. Participants with higher intelligence, better social cognitive performances, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. Our study demonstrated the feasibility of long-term intermittent theta burst stimulation over the posterior superior temporal sulcus in children and adolescents with autism spectrum disorder. However, the findings from the first 4-week blind trial do not support the therapeutic efficacy of intermittent theta burst stimulation over the posterior superior temporal sulcus on the clinical symptoms and cognitive performance of social impairment, given the current stimulation protocol. The exploratory analyses suggest that the therapeutic efficacy might be moderated by several individual characteristics and more intermittent theta burst stimulation sessions.

Published
2021
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21. PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model

Author

Chiu, Ching-Chi, Lu, Chin-Song, Weng, Yi-Hsin, Chen, Ying-Ling, Huang, Ying-Zu, Chen, Rou-Shayn, Cheng, Yi-Chuan, Huang, Yin-Cheng, Liu, Yu-Chuan, Lai, Szu-Chia, Lin, Kun-Jun, Lin, Yan-Wei, Chen, Yu-Jie, Chen, Chao-Lang, Yeh, Tu-Hsueh, and Wang, Hung-Li

Published
2019
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22. Theta burst stimulation of human cortex

Author

Huang, Ying-Zu

Subjects
616.8106845
Abstract

It has proved possible in experimental animals to manipulate synaptic efficiency using direct electrical stimulation of central nervous pathways. The introduction of transcranial methods of non-invasively stimulating the human brain raised hopes that similar effects could be produced in humans, with the potential for eventual therapeutic application in disease states. However, largely due to safety limitations, human subjects often require lengthy conditioning with repetitive transcranial magnetic stimulation (rTMS), and even then effects are often weak, variable and not beneficial in the therapeutic setting. In view of the difficulties, I have explored novel methods of conditioning the brain in conscious humans using rTMS which can swiftly produce powerful and controllable long-term changes in the excitability of cortical circuits.

Published
2005

30. Abnormal Bidirectional Plasticity-Like Effects in Parkinson's Disease

Author

Huang, Ying-Zu, Rothwell, John C., and Lu, Chin-Song

Abstract

Levodopa-induced dyskinesia is a major complication of long-term dopamine replacement therapy for Parkinson's disease that becomes increasingly problematic in advanced Parkinson's disease. Although the cause of levodopa-induced dyskinesias is still unclear, recent work in animal models of the corticostriatal system has suggested that levodopa-induced dyskinesias might result from abnormal control of synaptic plasticity. In the present study, we aimed to explore control of plasticity in patients with Parkinson's disease with and without levodopa-induced dyskinesias by taking advantage of a newly developed protocol that tests depotentiation of pre-existing long-term potentiation-like synaptic facilitation. Long-term potentiation-like plasticity and its reversibility were studied in the motor cortex of 10 healthy subjects, 10 patients with Parkinson's disease and levodopa-induced dyskinesias, who took half of the regular dose of levodopa and 10 patients with Parkinson's disease without levodopa-induced dyskinesias, who took either half or the full dose of levodopa. Patients with Parkinson's disease without levodopa-induced dyskinesias had normal long-term potentiation- and depotentiation-like effects when they took their full dose of levodopa, but there was no long-term potentiation-like effect when they were on half dose of levodopa. In contrast, patients with levodopa-induced dyskinesias could be successfully potentiated when they were on half their usual dose of levodopa; however, they were unresponsive to the depotentiation protocol. The results suggest that depotentiation is abnormal in the motor cortex of patients with Parkinson's disease with levodopa-induced dyskinesias and that their long-term potentiation-like plasticity is more readily affected by administration of levodopa than their clinical symptoms.

Published
2011
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48. Sonogenetic-Based Neuromodulation for the Amelioration of Parkinson’s Disease

Author

Fan, Ching-Hsiang, primary, Wei, Kuo-Chen, additional, Chiu, Nai-Hua, additional, Liao, En-Chi, additional, Wang, Hsien-Chu, additional, Wu, Ruo-Yu, additional, Ho, Yi-Ju, additional, Chan, Hong-Lin, additional, Wang, Tsung-Shing Andrew, additional, Huang, Ying-Zu, additional, Hsieh, Tsung-Hsun, additional, Lin, Chin-Hsien, additional, Lin, Yu-Chun, additional, and Yeh, Chih-Kuang, additional

Published
2021
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