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1. Defining the Time-limited Trial for Patients with Critical Illness: An Official American Thoracic Society Workshop Report.

Author

Rubin, Eileen, Schenker, Yael, Sullivan, Donald, Thornton, J, Viglianti, Elizabeth, Costa, Deena, Creutzfeldt, Claire, Detsky, Michael, Engel, Heidi, Grover, Neera, Hope, Aluko, Katz, Jason, Kohn, Rachel, Miller, Andrew, Nabozny, Michael, Nelson, Judith, Shanawani, Hasan, Stevens, Jennifer, Turnbull, Alison, Weiss, Curtis, Wirpsa, M, Cox, Christopher, Kruser, Jacqueline, Ashana, Deepshikha, Courtright, Katherine, Kross, Erin, and Neville, Thanh

Subjects
critical care, life-sustaining therapy, palliative care, shared decision making, Humans, United States, Decision Making, Critical Illness, Critical Care, Consensus, Patients
Abstract

In critical care, the specific, structured approach to patient care known as a time-limited trial has been promoted in the literature to help patients, surrogate decision makers, and clinicians navigate consequential decisions about life-sustaining therapy in the face of uncertainty. Despite promotion of the time-limited trial approach, a lack of consensus about its definition and essential elements prevents optimal clinical use and rigorous evaluation of its impact. The objectives of this American Thoracic Society Workshop Committee were to establish a consensus definition of a time-limited trial in critical care, identify the essential elements for conducting a time-limited trial, and prioritize directions for future work. We achieved these objectives through a structured search of the literature, a modified Delphi process with 100 interdisciplinary and interprofessional stakeholders, and iterative committee discussions. We conclude that a time-limited trial for patients with critical illness is a collaborative plan among clinicians and a patient and/or their surrogate decision makers to use life-sustaining therapy for a defined duration, after which the patients response to therapy informs the decision to continue care directed toward recovery, transition to care focused exclusively on comfort, or extend the trials duration. The plans 16 essential elements follow four sequential phases: consider, plan, support, and reassess. We acknowledge considerable gaps in evidence about the impact of time-limited trials and highlight a concern that if inadequately implemented, time-limited trials may perpetuate unintended harm. Future work is needed to better implement this defined, specific approach to care in practice through a person-centered equity lens and to evaluate its impact on patients, surrogates, and clinicians.

Published
2024

3. Thoracic Ultrasound in COVID-19: Use of Lung and Diaphragm Ultrasound in Evaluating Dyspnea in Survivors of Acute Respiratory Distress Syndrome from COVID-19 Pneumonia in a Post-ICU Clinic

Author

Eman, Gerardo, Synn, Shwe, Galen, Benjamin, Shah, Roshni, Nauka, Peter, Hope, Aluko A., and Congdon, Seth

Subjects
Lung diseases -- Usage, Clinics -- Usage, Medical colleges -- Usage, Health
Abstract

Introduction Dyspnea is a common symptom in survivors of severe COVID-19 pneumonia. While frequently employed in hospital settings, the use of point-of-care ultrasound in ambulatory clinics for dyspnea evaluation has rarely been explored. We aimed to determine how lung ultrasound score (LUS) and inspiratory diaphragm excursion (DE) correlate with patient-reported dyspnea during a 6-min walk test (6MWT) in survivors of COVID-19 acute respiratory distress syndrome (ARDS). We hypothesize higher LUS and lower DE will correlate with dyspnea severity. Study Design and Methods Single-center cross-sectional study of survivors of critically ill COVID-19 pneumonia (requiring high-flow nasal cannula, invasive, or non-invasive mechanical ventilation) seen in our Post-ICU clinic. All patients underwent standardized scanning protocols to compute LUS and DE. Pearson correlations were performed to detect an association between LUS and DE with dyspnea at rest and exertion during 6MWT. Results We enrolled 45 patients. Average age was 61.5 years (57.7% male), with average BMI of 32.3 Higher LUS correlated significantly with dyspnea, at rest (r = + 0.41, p = < 0.01) and at exertion (r = + 0.40, p = < 0.01). Higher LUS correlated significantly with lower oxygen saturation during 6MWT (r = -0.55, p = < 0.01) and lower 6MWT distance (r = -0.44, p = < 0.01). DE correlated significantly with 6MWT distance but did not correlate with dyspnea at rest or exertion. Conclusion Higher LUS correlated significantly with patient-reported dyspnea at rest and exertion. Higher LUS significantly correlated with more exertional oxygen desaturation during 6MWT and lower 6MWT distance. DE did not correlate with dyspnea., Author(s): Gerardo Eman [sup.1] [sup.4], Shwe Synn [sup.2], Benjamin Galen [sup.2], Roshni Shah [sup.2], Peter Nauka [sup.2], Aluko A. Hope [sup.3], Seth Congdon [sup.2], Marjan Islam [sup.1] Author Affiliations: (1) [...]

Published
2023
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4. The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data

Author

Bruno, Raphael Romano, Wernly, Bernhard, Bagshaw, Sean M., van den Boogaard, Mark, Darvall, Jai N., De Geer, Lina, de Gopegui Miguelena, Pablo Ruiz, Heyland, Daren K., Hewitt, David, Hope, Aluko A., Langlais, Emilie, Le Maguet, Pascale, Montgomery, Carmel L., Papageorgiou, Dimitrios, Seguin, Philippe, Geense, Wytske W., Silva-Obregón, J. Alberto, Wolff, Georg, Polzin, Amin, Dannenberg, Lisa, Kelm, Malte, Flaatten, Hans, Beil, Michael, Franz, Marcus, Sviri, Sigal, Leaver, Susannah, Guidet, Bertrand, Boumendil, Ariane, and Jung, Christian

Published
2023
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5. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Author

Goligher, Ewan C, Bradbury, Charlotte A, McVerry, Bryan J, Lawler, Patrick R, Berger, Jeffrey S, Gong, Michelle N, Carrier, Marc, Reynolds, Harmony R, Kumar, Anand, Turgeon, Alexis F, Kornblith, Lucy Z, Kahn, Susan R, Marshall, John C, Kim, Keri S, Houston, Brett L, Derde, Lennie PG, Cushman, Mary, Tritschler, Tobias, Angus, Derek C, Godoy, Lucas C, McQuilten, Zoe, Kirwan, Bridget-Anne, Farkouh, Michael E, Brooks, Maria M, Lewis, Roger J, Berry, Lindsay R, Lorenzi, Elizabeth, Gordon, Anthony C, Ahuja, Tania, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Contreras, Aira, Costantini, Todd W, de Brouwer, Sophie, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Eng, Heather F, Escobedo, Jorge, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Froess, Joshua D, Fu, Zhuxuan, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, Girard, Timothy D, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Haniffa, Rashan, Hegde, Sheila M, Hendrickson, Carolyn M, Higgins, Alisa M, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Huang, David T, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei, King, Andrew J, Knudson, M Margaret, Kornblith, Aaron E, Kutcher, Matthew E, Laffan, Michael A, Lamontagne, Francois, and Le Gal, Grégoire

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Comparative Effectiveness Research, Cardiovascular, Good Health and Well Being, Aged, Anticoagulants, COVID-19, Critical Illness, Female, Hemorrhage, Heparin, Hospital Mortality, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Respiration, Artificial, Thrombosis, Treatment Failure, COVID-19 Drug Treatment, REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundThrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.MethodsIn an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined regimen of either therapeutic-dose anticoagulation with heparin or pharmacologic thromboprophylaxis in accordance with local usual care. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge.ResultsThe trial was stopped when the prespecified criterion for futility was met for therapeutic-dose anticoagulation. Data on the primary outcome were available for 1098 patients (534 assigned to therapeutic-dose anticoagulation and 564 assigned to usual-care thromboprophylaxis). The median value for organ support-free days was 1 (interquartile range, -1 to 16) among the patients assigned to therapeutic-dose anticoagulation and was 4 (interquartile range, -1 to 16) among the patients assigned to usual-care thromboprophylaxis (adjusted proportional odds ratio, 0.83; 95% credible interval, 0.67 to 1.03; posterior probability of futility [defined as an odds ratio

Published
2021

6. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

Author

Lawler, Patrick R, Goligher, Ewan C, Berger, Jeffrey S, Neal, Matthew D, McVerry, Bryan J, Nicolau, Jose C, Gong, Michelle N, Carrier, Marc, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Escobedo, Jorge, Huang, David T, Bradbury, Charlotte A, Houston, Brett L, Kornblith, Lucy Z, Kumar, Anand, Kahn, Susan R, Cushman, Mary, McQuilten, Zoe, Slutsky, Arthur S, Kim, Keri S, Gordon, Anthony C, Kirwan, Bridget-Anne, Brooks, Maria M, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Aday, Aaron W, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Costantini, Todd W, de Brouwer, Sophie, Derde, Lennie PG, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, García-Madrona, Sebastian, Girard, Timothy D, Godoy, Lucas C, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Hamburg, Naomi M, Haniffa, Rashan, Hanna, George, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Iyer, Vivek N, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei L, King, Andrew J, Knudson, M Margaret, Kornblith, Aaron E, and Krishnan, Vidya

Subjects
Cardiovascular, Clinical Trials and Supportive Activities, Clinical Research, Hematology, Transplantation, Good Health and Well Being, Adult, Aged, Anticoagulants, COVID-19, Female, Hemorrhage, Heparin, Heparin, Low-Molecular-Weight, Hospital Mortality, Humans, Male, Middle Aged, Survival Analysis, Thrombosis, COVID-19 Drug Treatment, ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundThrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.MethodsIn this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care-level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge. This outcome was evaluated with the use of a Bayesian statistical model for all patients and according to the baseline d-dimer level.ResultsThe trial was stopped when prespecified criteria for the superiority of therapeutic-dose anticoagulation were met. Among 2219 patients in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support-free days as compared with usual-care thromboprophylaxis was 98.6% (adjusted odds ratio, 1.27; 95% credible interval, 1.03 to 1.58). The adjusted absolute between-group difference in survival until hospital discharge without organ support favoring therapeutic-dose anticoagulation was 4.0 percentage points (95% credible interval, 0.5 to 7.2). The final probability of the superiority of therapeutic-dose anticoagulation over usual-care thromboprophylaxis was 97.3% in the high d-dimer cohort, 92.9% in the low d-dimer cohort, and 97.3% in the unknown d-dimer cohort. Major bleeding occurred in 1.9% of the patients receiving therapeutic-dose anticoagulation and in 0.9% of those receiving thromboprophylaxis.ConclusionsIn noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589, NCT04505774, NCT04359277, and NCT02735707.).

Published
2021

7. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

Author

REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher, Ewan C, Bradbury, Charlotte A, McVerry, Bryan J, Lawler, Patrick R, Berger, Jeffrey S, Gong, Michelle N, Carrier, Marc, Reynolds, Harmony R, Kumar, Anand, Turgeon, Alexis F, Kornblith, Lucy Z, Kahn, Susan R, Marshall, John C, Kim, Keri S, Houston, Brett L, Derde, Lennie PG, Cushman, Mary, Tritschler, Tobias, Angus, Derek C, Godoy, Lucas C, McQuilten, Zoe, Kirwan, Bridget-Anne, Farkouh, Michael E, Brooks, Maria M, Lewis, Roger J, Berry, Lindsay R, Lorenzi, Elizabeth, Gordon, Anthony C, Ahuja, Tania, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Contreras, Aira, Costantini, Todd W, de Brouwer, Sophie, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Eng, Heather F, Escobedo, Jorge, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Froess, Joshua D, Fu, Zhuxuan, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, Girard, Timothy D, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Haniffa, Rashan, Hegde, Sheila M, Hendrickson, Carolyn M, Higgins, Alisa M, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Huang, David T, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei, King, Andrew J, Knudson, M Margaret, Kornblith, Aaron E, and Kutcher, Matthew E

Subjects
REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Humans, Thrombosis, Critical Illness, Hemorrhage, Heparin, Anticoagulants, Treatment Failure, Respiration, Artificial, Hospital Mortality, Logistic Models, Odds Ratio, Aged, Middle Aged, Female, Male, COVID-19, Clinical Research, Cardiovascular, Clinical Trials and Supportive Activities, Comparative Effectiveness Research, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.MethodsIn an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined regimen of either therapeutic-dose anticoagulation with heparin or pharmacologic thromboprophylaxis in accordance with local usual care. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge.ResultsThe trial was stopped when the prespecified criterion for futility was met for therapeutic-dose anticoagulation. Data on the primary outcome were available for 1098 patients (534 assigned to therapeutic-dose anticoagulation and 564 assigned to usual-care thromboprophylaxis). The median value for organ support-free days was 1 (interquartile range, -1 to 16) among the patients assigned to therapeutic-dose anticoagulation and was 4 (interquartile range, -1 to 16) among the patients assigned to usual-care thromboprophylaxis (adjusted proportional odds ratio, 0.83; 95% credible interval, 0.67 to 1.03; posterior probability of futility [defined as an odds ratio

Published
2021

8. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

Author

ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, Patrick R, Goligher, Ewan C, Berger, Jeffrey S, Neal, Matthew D, McVerry, Bryan J, Nicolau, Jose C, Gong, Michelle N, Carrier, Marc, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Escobedo, Jorge, Huang, David T, Bradbury, Charlotte A, Houston, Brett L, Kornblith, Lucy Z, Kumar, Anand, Kahn, Susan R, Cushman, Mary, McQuilten, Zoe, Slutsky, Arthur S, Kim, Keri S, Gordon, Anthony C, Kirwan, Bridget-Anne, Brooks, Maria M, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Aday, Aaron W, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Costantini, Todd W, de Brouwer, Sophie, Derde, Lennie PG, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, García-Madrona, Sebastian, Girard, Timothy D, Godoy, Lucas C, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Hamburg, Naomi M, Haniffa, Rashan, Hanna, George, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Iyer, Vivek N, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei L, and King, Andrew J

Subjects
ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Humans, Thrombosis, Hemorrhage, Heparin, Heparin, Low-Molecular-Weight, Anticoagulants, Hospital Mortality, Survival Analysis, Adult, Aged, Middle Aged, Female, Male, COVID-19, Hematology, Clinical Trials and Supportive Activities, Transplantation, Clinical Research, Cardiovascular, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.MethodsIn this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an absence of critical care-level organ support at enrollment) to receive pragmatically defined regimens of either therapeutic-dose anticoagulation with heparin or usual-care pharmacologic thromboprophylaxis. The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death (assigned a value of -1) and the number of days free of cardiovascular or respiratory organ support up to day 21 among patients who survived to hospital discharge. This outcome was evaluated with the use of a Bayesian statistical model for all patients and according to the baseline d-dimer level.ResultsThe trial was stopped when prespecified criteria for the superiority of therapeutic-dose anticoagulation were met. Among 2219 patients in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support-free days as compared with usual-care thromboprophylaxis was 98.6% (adjusted odds ratio, 1.27; 95% credible interval, 1.03 to 1.58). The adjusted absolute between-group difference in survival until hospital discharge without organ support favoring therapeutic-dose anticoagulation was 4.0 percentage points (95% credible interval, 0.5 to 7.2). The final probability of the superiority of therapeutic-dose anticoagulation over usual-care thromboprophylaxis was 97.3% in the high d-dimer cohort, 92.9% in the low d-dimer cohort, and 97.3% in the unknown d-dimer cohort. Major bleeding occurred in 1.9% of the patients receiving therapeutic-dose anticoagulation and in 0.9% of those receiving thromboprophylaxis.ConclusionsIn noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589, NCT04505774, NCT04359277, and NCT02735707.).

Published
2021

10. Functional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational study

Author

Mayer, Kirby P., Palakshappa, Jessica A., Peltan, Ithan Daniel, Andrew, James S., Gundel, Stephanie J., Ringwood, Nancy J., Mckeehan, Jeffrey, Hope, Aluko A., Rogers, Angela J., Biehl, Michelle, Hayden, Douglas L., Caldwell, Ellen, Mehkri, Omar, Lynch, David J., Burham, Ellen L., Hough, Catherine L., and Jolley, Sarah E.

Published
2022
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11. Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults

Author

Han, Jin H., Ginde, Adit A., Brown, Samuel M., Baughman, Adrienne, Collar, Erin M., Ely, E. Wesley, Gong, Michelle N., Hope, Aluko A., Hou, Peter C., Hough, Catherine L., Iwashyna, Theodore J., Jackson, James C., Khan, Akram, Orun, Onur M., Patel, Mayur B., Raman, Rameela, Rice, Todd W., Ringwood, Nancy, Semler, Matthew W., Shapiro, Nathan I., Talmor, Daniel S., and Self, Wesley H.

Published
2021
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12. Patient and Caregiver-Derived Health Service Improvements for Better Critical Care Recovery

Author

Haines, Kimberley J., Leggett, Nina, Hibbert, Elizabeth, Hall, Tarli, Boehm, Leanne M., Bakhru, Rita N., Bastin, Anthony J., Butcher, Brad W., Eaton, Tammy L., Harris, Wendy, Hope, Aluko A., Jackson, James, Johnson, Annie, Kloos, Janet A., Korzick, Karen A., Mactavish, Pamela, Meyer, Joel, Montgomery-Yates, Ashley, Quasim, Tara, Slack, Andrew, Wade, Dorothy, Still, Mary, Netzer, Giora, Hopkins, Ramona O., Mikkelsen, Mark E., Iwashyna, Theodore J., McPeake, Joanne, and Sevin, Carla M.

Published
2022
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14. Defining the Time-limited Trial for Patients with Critical Illness: An Official American Thoracic Society Workshop Report

Author

Kruser, Jacqueline M., primary, Ashana, Deepshikha C., additional, Courtright, Katherine R., additional, Kross, Erin K., additional, Neville, Thanh H., additional, Rubin, Eileen, additional, Schenker, Yael, additional, Sullivan, Donald R., additional, Thornton, J. Daryl, additional, Viglianti, Elizabeth M., additional, Costa, Deena Kelly, additional, Creutzfeldt, Claire J., additional, Detsky, Michael E., additional, Engel, Heidi J., additional, Grover, Neera, additional, Hope, Aluko A., additional, Katz, Jason N., additional, Kohn, Rachel, additional, Miller, Andrew G., additional, Nabozny, Michael J., additional, Nelson, Judith E., additional, Shanawani, Hasan, additional, Stevens, Jennifer P., additional, Turnbull, Alison E., additional, Weiss, Curtis H., additional, Wirpsa, M. Jeanne, additional, and Cox, Christopher E., additional

Published
2024
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15. Transitions of Care After Critical Illness—Challenges to Recovery and Adaptive Problem Solving*

Author

Haines, Kimberley J., Hibbert, Elizabeth, Leggett, Nina, Boehm, Leanne M., Hall, Tarli, Bakhru, Rita N., Bastin, Anthony J., Butcher, Brad W., Eaton, Tammy L., Harris, Wendy, Hope, Aluko A., Jackson, James, Johnson, Annie, Kloos, Janet A., Korzick, Karen A., Mactavish, Pamela, Meyer, Joel, Montgomery-Yates, Ashley, Quasim, Tara, Slack, Andrew, Wade, Dorothy, Still, Mary, Netzer, Giora, Hopkins, Ramona O., Iwashyna, Theodore J., Mikkelsen, Mark E., McPeake, Joanne, and Sevin, Carla M.

Published
2021
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19. Society of Critical Care Medicine’s International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness

Author

Mikkelsen, Mark E., Still, Mary, Anderson, Brian J., Bienvenu, O. Joseph, Brodsky, Martin B., Brummel, Nathan, Butcher, Brad, Clay, Alison S., Felt, Hali, Ferrante, Lauren E., Haines, Kimberley J., Harhay, Michael O., Hope, Aluko A., Hopkins, Ramona O., Hosey, Megan, Hough, Catherine “Terri” L., Jackson, James C., Johnson, Annie, Khan, Babar, Lone, Nazir I., MacTavish, Pamela, McPeake, Joanne, Montgomery-Yates, Ashley, Needham, Dale M., Netzer, Giora, Schorr, Christa, Skidmore, Becky, Stollings, Joanna L., Umberger, Reba, Andrews, Adair, Iwashyna, Theodore J., and Sevin, Carla M.

Published
2020
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21. Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives

Author

Haines, Kimberley J., Sevin, Carla M., Hibbert, Elizabeth, Boehm, Leanne M., Aparanji, Krishna, Bakhru, Rita N., Bastin, Anthony J., Beesley, Sarah J., Butcher, Brad W., Drumright, Kelly, Eaton, Tammy L., Farley, Thomas, Firshman, Penelope, Fritschle, Andrew, Holdsworth, Clare, Hope, Aluko A., Johnson, Annie, Kenes, Michael T., Khan, Babar A., Kloos, Janet A., Kross, Erin K., MacLeod-Smith, Belinda J., Mactavish, Pamela, Meyer, Joel, Montgomery-Yates, Ashley, Quasim, Tara, Saft, Howard L., Slack, Andrew, Stollings, Joanna, Weinhouse, Gerald, Whitten, Jessica, Netzer, Giora, Hopkins, Ramona O., Mikkelsen, Mark E., Iwashyna, Theodore J., and McPeake, Joanne

Published
2019
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23. Importance of Reconnection With ICU Survivors to ICU Recovery Program Clinicians

Author

Eaton, Tammy L., primary, Danesh, Valerie, additional, Sevin, Carla M., additional, Potter, Kelly, additional, Su, Han, additional, Iwashyna, Theodore J., additional, Boehm, Leanne M., additional, McPeake, Joanne, additional, Bernstein, Taylor, additional, Bakhru, Rita N., additional, Baram, Michael, additional, Biehl, Michelle, additional, Bellinghausen, Amy L., additional, Boyd, J. Gordon, additional, Butcher, Brad W., additional, Dalton, Melanie, additional, Dangayach, Neha S., additional, Enfield, Kyle B., additional, Hoehn, K. Sarah, additional, Hope, Aluko A., additional, Hornstein, David, additional, Jagpal, Sugeet, additional, Jolley, Sarah E., additional, Khan, Babar A., additional, Kenes, Michael T., additional, Kloos, Janet, additional, Korzick, Karen A., additional, Lief, Lindsay, additional, Mahoney, Eric, additional, Maley, Jason H., additional, Mayer, Kirby P., additional, McNeal, Tresa, additional, McSparron, Jakob I., additional, Meyer, Joel, additional, Mohammad, Rima A., additional, Montgomery-Yates, Ashley, additional, Nomellini, Vanessa, additional, Parker, Ann M., additional, Popovich, Kehllee, additional, Poyant, Janelle, additional, Quasim, Tara, additional, Saft, Howard, additional, Santhosh, Lekshmi, additional, Schwab, Kristin, additional, Slack, Andrew, additional, Stollings, Joanna L., additional, Sousa, David, additional, Torbic, Heather, additional, Valley, Thomas S., additional, and Villalba, Dario, additional

Published
2023
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26. Key Components of ICU Recovery Programs: What Did Patients Report Provided Benefit?

Author

McPeake, Joanne, Boehm, Leanne M., Hibbert, Elizabeth, Bakhru, Rita N., Bastin, Anthony J., Butcher, Brad W., Eaton, Tammy L., Harris, Wendy, Hope, Aluko A., Jackson, James, Johnson, Annie, Kloos, Janet A., Korzick, Karen A., MacTavish, Pamela, Meyer, Joel, Montgomery-Yates, Ashley, Quasim, Tara, Slack, Andrew, Wade, Dorothy, Still, Mary, Netzer, Giora, Hopkins, Ramona O., Mikkelsen, Mark E., Iwashyna, Theodore J., Haines, Kimberley J., and Sevin, Carla M.

Published
2020
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30. Models of Peer Support to Remediate Post-Intensive Care Syndrome: A Report Developed by the Society of Critical Care Medicine Thrive International Peer Support Collaborative*

Author

McPeake, Joanne, Hirshberg, Eliotte L., Christie, Leeann M., Drumright, Kelly, Haines, Kimberley, Hough, Catherine L., Meyer, Joel, Wade, Dorothy, Andrews, Adair, Bakhru, Rita, Bates, Samantha, Barwise, John A., Bastarache, Julie, Beesley, Sarah J., Boehm, Leanne M., Brown, Sheryl, Clay, Alison S., Firshman, Penelope, Greenberg, Steven, Harris, Wendy, Hill, Christopher, Hodgson, Carol, Holdsworth, Clare, Hope, Aluko A., Hopkins, Ramona O., Howell, David C. J., Janssen, Anna, Jackson, James C., Johnson, Annie, Kross, Erin K., Lamas, Daniela, MacLeod-Smith, Belinda, Mandel, Ruth, Marshall, John, Mikkelsen, Mark E., Nackino, Megan, Quasim, Tara, Sevin, Carla M., Slack, Andrew, Spurr, Rachel, Still, Mary, Thompson, Carol, Weinhouse, Gerald, Wilcox, M. Elizabeth, and Iwashyna, Theodore J.

Published
2019
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33. Importance of Reconnection With ICU Survivors to ICU Recovery Program Clinicians

Author

Bernstein, Taylor, Bakhru, Rita N., Baram, Michael, Biehl, Michelle, Bellinghausen, Amy L., Boyd, J. Gordon, Butcher, Brad W., Dalton, Melanie, Dangayach, Neha S., Enfield, Kyle B., Hoehn, K. Sarah, Hope, Aluko A., Hornstein, David, Jagpal, Sugeet, Jolley, Sarah E., Khan, Babar A., Kenes, Michael T., Kloos, Janet, Korzick, Karen A., Lief, Lindsay, Mahoney, Eric, Maley, Jason H., Mayer, Kirby P., McNeal, Tresa, McSparron, Jakob I., Meyer, Joel, Mohammad, Rima A., Montgomery-Yates, Ashley, Nomellini, Vanessa, Parker, Ann M., Popovich, Kehllee, Poyant, Janelle, Quasim, Tara, Saft, Howard, Santhosh, Lekshmi, Schwab, Kristin, Slack, Andrew, Stollings, Joanna L., Sousa, David, Torbic, Heather, Valley, Thomas S., Villalba, Dario, Eaton, Tammy L., Danesh, Valerie, Sevin, Carla M., Potter, Kelly, Su, Han, Iwashyna, Theodore J., Boehm, Leanne M., and McPeake, Joanne

Published
2023
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35. Modification of social determinants of health by critical illness and consequences of that modification for recovery: an international qualitative study

Author

McPeake, Joanne M., Boehm, Leanne M., Hibbert, Elizabeth, Hauschildt, Katrina, Bakhru, Rita N., Bastin, Anthony J., Butcher, Brad W., Eaton, Tammy L., Harris, Wendy, Hope, Aluko A., Jackson, James, Johnson, Annie, Kloos, Janet A., Korzick, Karen A., McCartney, Judith, Meyer, Joel, Montgomery-Yates, Ashley, Quasim, Tara, Slack, Andrew, Wade, Dorothy, Still, Mary, Netzer, Giora, Hopkins, Ramona O., Mikkelsen, Mark E., Iwashyna, Theodore J., Haines, Kimberley J., Sevin, Carla M., McPeake, Joanne [0000-0001-8206-6801], Haines, Kimberley [0000-0002-2882-1594], and Apollo - University of Cambridge Repository

Subjects
Caregivers, Social Determinants of Health, Critical Illness, public health, Humans, General Medicine, Survivors, adult intensive & critical care, Qualitative Research
Abstract

ObjectivesSocial determinants of health (SDoH) contribute to health outcomes. We identified SDoH that were modified by critical illness, and the effect of such modifications on recovery from critical illness.DesignIn-depth semistructured interviews following hospital discharge. Interview transcripts were mapped against a pre-existing social policy framework: money and work; skills and education; housing, transport and neighbourhoods; and family, friends and social connections.Setting14 hospital sites in the USA, UK and Australia.ParticipantsPatients and caregivers, who had been admitted to critical care from three continents.Results86 interviews were analysed (66 patients and 20 caregivers). SDoH, both financial and non-financial in nature, could be negatively influenced by exposure to critical illness, with a direct impact on health-related outcomes at an individual level. Financial modifications included changes to employment status due to critical illness-related disability, alongside changes to income and insurance status. Negative health impacts included the inability to access essential healthcare and an increase in mental health problems.ConclusionsCritical illness appears to modify SDoH for survivors and their family members, potentially impacting recovery and health. Our findings suggest that increased attention to issues such as one’s social network, economic security and access to healthcare is required following discharge from critical care.

Published
2022
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39. Frailty, Acute Brain Dysfunction, and Posthospitalization Disability Outcomes in Critically Ill Older Adults.

Author

Caldwell, Corrielle, Verghese, Joe, Gong, Michelle N., Kim, Mimi, and Hope, Aluko A.

Subjects
INTENSIVE care units, FRAIL elderly, CONFIDENCE intervals, CRITICALLY ill, PATIENTS, HEALTH outcome assessment, ACTIVITIES of daily living, TREATMENT effectiveness, COMPARATIVE studies, DELIRIUM, DESCRIPTIVE statistics, DISABILITIES, COMA, PEOPLE with disabilities, ODDS ratio, PREDICTION models, DISCHARGE planning, LONGITUDINAL method, DISEASE complications, OLD age
Abstract

Background: Identifying potentially modifiable factors that mediate adverse outcomes in frail adults with critical illness may facilitate development of interventions to improve intensive care unit (ICU) survivorship. Objectives: To estimate the relationship between frailty, acute brain dysfunction (as reflected by delirium or persistent coma), and 6-month disability outcomes. Methods: Older adults (aged ≥50 years) admitted to the ICU were enrolled prospectively. Frailty was identified with the Clinical Frailty Scale. Delirium and coma were assessed daily with the Confusion Assessment Method for the ICU and the Richmond Agitation-Sedation Scale, respectively. Disability outcomes (death and severe physical disability [defined as new dependence in 5 or more activities of daily living]) were assessed by telephone within 6 months after discharge. Results: In 302 older adults (mean [SD] age, 67.2 [10.8] y), both frail and vulnerable patients had a higher risk for acute brain dysfunction (adjusted odds ratio [AOR], 2.9 [95% CI, 1.5-5.6], and 2.0 [95% CI, 1.0-4.1], respectively) compared with fit patients. Both frailty and acute brain dysfunction were independently associated with death or severe disability at 6 months (AOR, 3.3 [95% CI, 1.6-6.5] and 2.4 [95% CI, 1.4 -4.0], respectively). The average proportion of the frailty effect mediated by acute brain dysfunction was estimated to be 12.6% (95% CI, 2.1%-23.1%; P =.02). Conclusion: Frailty and acute brain dysfunction were important independent predictors of disability outcomes in older adults with critical illness. Acute brain dysfunction may be an important mediator of increased risk for physical disability outcomes after critical illness. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Healthcare delivery and recovery after critical illness

Author

Hope, Aluko A. and McPeake, Joanne

Subjects
Adult, Intensive Care Units, Critical Illness, Quality of Life, Humans, Survivors, Critical Care and Intensive Care Medicine, Delivery of Health Care
Abstract

Purpose of review: \ud \ud To summarize improvements and innovations in healthcare delivery which could be implemented to improve the recovery experience after critical illness for adult survivors and their families.\ud \ud Recent findings: \ud \ud For survivors of critical illness, the transitions in care during their recovery journey are points of heightened vulnerability associated with adverse events. Survivors of critical illness often have errors in the management of their medications during the recovery period. A multicomponent intervention delivered for 30 days that focused on four key principles of improved recovery care after sepsis care was associated with a durable effect on 12-month rehospitalization and mortality compared with usual care. A recent multicentre study which piloted integrating health and social care for critical care survivors demonstrated improvements in health-related quality of life and self-efficacy at 12 months. Multiple qualitative studies provide insights into how peer support programmes could potentially benefit survivors of critical illness by providing them mechanism to share their experiences, to give back to other patients, and to set more realistic expectations for recovery.\ud \ud Summary: \ud \ud Future research could focus on exploring safety outcomes as primary endpoints and finding ways to develop and test implementation strategies to improve the recovery after critical illness.

Published
2022

41. What the American Journal of Critical Care Junior Peer Reviewers Were Reading During Year 2 of the Program

Author

Smith, L. Douglas, primary, Alne, Thomas, additional, Briere, Heather, additional, Hernandez, Angelica, additional, Freeman, Regi, additional, Gabel, Katie, additional, Berube, Jennifer, additional, Carreon, Christian Justin, additional, Grimshaw, Kelly S., additional, Indar-Maraj, Mintie, additional, Ledford, Lori, additional, Rosier, Patricia, additional, Tyner, Tracy, additional, Walker, Janeane, additional, and Hope, Aluko A., additional

Published
2022
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43. What the American Journal of Critical Care Junior Peer Reviewers Were Reading During the First Year of the Program: Caring for Patients With COVID-19

Author

Smith, L. Douglas, primary, Berube, Jennifer, additional, Indar-Maraj, Mintie, additional, Rosier, Patricia, additional, Walker, Janeane, additional, Carreon, Christian Justin, additional, Freeman, Regi, additional, Gabel, Katie, additional, Hernandez, Angelica, additional, Kolmer, Meghan, additional, Proctor, Tamala, additional, and Hope, Aluko A., additional

Published
2022
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47. Organization of Outpatient Care After COVID-19 Hospitalization

Author

Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Lesley, Baron, Rebecca M., Pinilla-Vera, Mayra, Rubins, David M., Arciniegas, Antonio, Riker, Richard, Lord, Christine, Elie, Marie-Carmelle, Talmor, Daniel, Shapiro, Nathan, Banner-Goodspeed, Valerie, Hibbert, Kathryn A., Brait, Kelsey, Pulido, Natalie, Jones, Alan, Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Davis, Jenna, Prekker, Matthew, Puskarich, Michael, Jones, Seth, Roerhl, Anne, Hendrickson, Audrey, Matthay, Michael, Kangelaris, Kirsten, Liu, Kathleen, Yee, Kimberly, Zhuo, Hanjing, Hendey, Gregory, Chang, Steven, Qadir, Nida, Tam, Andrea, Beutler, Rebecca, Agarwal, Trisha, Levitt, Joseph, Wilson, Jennifer G., Rogers, Angela, Roque, Jonasel, Vojnik, Rosemary, Albertson, Timothy E., Chenoweth, James A., Adams, Jason Y., Morrissey, Brian M., Pearson, Skyler J., Almasri, Eyad, Hughes, Alyssa, Moss, Marc, Ginde, Adit, McKeehan, Jeffrey, Finck, Lani, Howell, Michelle, Higgins, Carrie, Haukoos, Jason, Gravitz, Stephanie, Lyle, Carolynn, Douglas, Ivor S., Hiller, Terra, Goold, Audrey, Finigan, James, Hyzy, Robert, Park, Pauline, Sjoding, Michael, Kay, Stephen, Nelson, Kristine, McDonough, Kelli, Jayaprakash, Namita, Rivers, Emanuel P., Swiderek, Jennifer, Gill, Jasreen Kaur, Day, Jacqueline, Sherwin, Robert, Wooden, James, Mazzoco, Thomas, Gong, Michelle Ng, Aboodi, Michael, Asghar, Ayesha, Amosu, Omowunmi, Tzehaie, Hiwet, Hope, Aluko A., Chen, Jen-Ting, Nair, Rahul, Lopez, Brenda, Offor, Obiageli, Mosier, Jarrod M., Hypes, Cameron D., Salvagio, Elizabeth, Bime, Christian, Cristan, Elaine, Richardson, Lynne D., Mathews, Kusum S., Goel, Neha, Maher, Patrick, Acquah, Samuel, Cardone, Donald, Oldenburg, Gary, Dunn, Andrew, Hite, Duncan, Hudock, Kristin, Arroyo, Jose Gomez, Roads, Tammy, Duggal, Abhijit, Mireles-Cabodevila, Eduardo, Robinson, Bryce R.H., Johnson, Nicholas J., Gundel, Stephanie, Evans, Laura, O'Mahony, D. Shane, Wallick, Julie A., Pedraza, Isabel, Hough, Catherine L., Khan, Akram, Krol, Olivia, Jouzestani, Milad Karami, Vranas, Kelly, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra, Huang, David T., Boeltz-Skrtich, Aimee, Moore, Steven, Isenberg, Derek, Files, D. Clark, Miller, Chadwick, Gibbs, Kevin, Flores, Lori, LaRose, Mary, Koehler, Lauren, Landreth, Leigha, Morris, Peter, Cassity, Evan, Sturgill, Jamie, Mayer, Kirby, Montgomery-Yates, Ashley, de Wit, Marjolein, Mason, Jessica, Goodwin, Andrew, Grady, Abigail, Burch, Patterson, Enfield, Kyle B., Sturek, Jeffrey M., Marshall, Mary, Bledsoe, Joseph R., Brown, Samuel M., Peltan, Ithan D., Grissom, Colin K., Armbruster, Brent, Harris, Estelle, Eppensteiner, John, Hall, Bria Johnston, Hall, Grace L., McGowan, Lauren, Bouffler, Andrew, Walker, Erica, Francis, Samuel, Porter, Tedra, deBoisblanc, Bennett P., Lammi, Matthew R., Janz, David R., Lauto, Paula, Romaine, Connie, Sandi, Marie, Rice, Todd W., Self, Wesley H., Ringwood, Nancy, Nagrebetsky, Alexander, Fitzgerald, Laura, Brower, Roy G., Reineck, Lora A., Aggarwal, Neil R., Bienstock, Karen, Valley, Thomas S., Schutz, Amanda, Vranas, Kelly C., Jolley, Sarah E., and Palakshappa, Jessica A.

Published
2022
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48. Organization of Outpatient Care After COVID-19 Hospitalization

Author

Valley, Thomas S., primary, Schutz, Amanda, additional, Peltan, Ithan D., additional, Vranas, Kelly C., additional, Mathews, Kusum S., additional, Jolley, Sarah E., additional, Palakshappa, Jessica A., additional, Hough, Catherine L., additional, Steingrub, Jay S., additional, Tidswell, Mark A., additional, Kozikowski, Lori-Ann, additional, Kardos, Cynthia, additional, DeSouza, Lesley, additional, Baron, Rebecca M., additional, Pinilla-Vera, Mayra, additional, Rubins, David M., additional, Arciniegas, Antonio, additional, Riker, Richard, additional, Lord, Christine, additional, Elie, Marie-Carmelle, additional, Talmor, Daniel, additional, Shapiro, Nathan, additional, Banner-Goodspeed, Valerie, additional, Hibbert, Kathryn A., additional, Brait, Kelsey, additional, Pulido, Natalie, additional, Jones, Alan, additional, Galbraith, James, additional, Nandi, Utsav, additional, Peacock, Rebekah, additional, Davis, Jenna, additional, Prekker, Matthew, additional, Puskarich, Michael, additional, Jones, Seth, additional, Roerhl, Anne, additional, Hendrickson, Audrey, additional, Matthay, Michael, additional, Kangelaris, Kirsten, additional, Liu, Kathleen, additional, Yee, Kimberly, additional, Zhuo, Hanjing, additional, Hendey, Gregory, additional, Chang, Steven, additional, Qadir, Nida, additional, Tam, Andrea, additional, Beutler, Rebecca, additional, Agarwal, Trisha, additional, Levitt, Joseph, additional, Wilson, Jennifer G., additional, Rogers, Angela, additional, Roque, Jonasel, additional, Vojnik, Rosemary, additional, Albertson, Timothy E., additional, Chenoweth, James A., additional, Adams, Jason Y., additional, Morrissey, Brian M., additional, Pearson, Skyler J., additional, Almasri, Eyad, additional, Hughes, Alyssa, additional, Moss, Marc, additional, Ginde, Adit, additional, McKeehan, Jeffrey, additional, Finck, Lani, additional, Howell, Michelle, additional, Higgins, Carrie, additional, Haukoos, Jason, additional, Gravitz, Stephanie, additional, Lyle, Carolynn, additional, Douglas, Ivor S., additional, Hiller, Terra, additional, Goold, Audrey, additional, Finigan, James, additional, Hyzy, Robert, additional, Park, Pauline, additional, Sjoding, Michael, additional, Kay, Stephen, additional, Nelson, Kristine, additional, McDonough, Kelli, additional, Jayaprakash, Namita, additional, Rivers, Emanuel P., additional, Swiderek, Jennifer, additional, Gill, Jasreen Kaur, additional, Day, Jacqueline, additional, Sherwin, Robert, additional, Wooden, James, additional, Mazzoco, Thomas, additional, Gong, Michelle Ng, additional, Aboodi, Michael, additional, Asghar, Ayesha, additional, Amosu, Omowunmi, additional, Tzehaie, Hiwet, additional, Hope, Aluko A., additional, Chen, Jen-Ting, additional, Nair, Rahul, additional, Lopez, Brenda, additional, Offor, Obiageli, additional, Mosier, Jarrod M., additional, Hypes, Cameron D., additional, Salvagio, Elizabeth, additional, Bime, Christian, additional, Cristan, Elaine, additional, Richardson, Lynne D., additional, Goel, Neha, additional, Maher, Patrick, additional, Acquah, Samuel, additional, Cardone, Donald, additional, Oldenburg, Gary, additional, Dunn, Andrew, additional, Hite, Duncan, additional, Hudock, Kristin, additional, Arroyo, Jose Gomez, additional, Roads, Tammy, additional, Duggal, Abhijit, additional, Mireles-Cabodevila, Eduardo, additional, Robinson, Bryce R.H., additional, Johnson, Nicholas J., additional, Gundel, Stephanie, additional, Evans, Laura, additional, O'Mahony, D. Shane, additional, Wallick, Julie A., additional, Pedraza, Isabel, additional, Khan, Akram, additional, Krol, Olivia, additional, Jouzestani, Milad Karami, additional, Vranas, Kelly, additional, Yealy, Donald M., additional, Angus, Derek C., additional, Weissman, Alexandra, additional, Huang, David T., additional, Boeltz-Skrtich, Aimee, additional, Moore, Steven, additional, Isenberg, Derek, additional, Files, D. Clark, additional, Miller, Chadwick, additional, Gibbs, Kevin, additional, Flores, Lori, additional, LaRose, Mary, additional, Koehler, Lauren, additional, Landreth, Leigha, additional, Morris, Peter, additional, Cassity, Evan, additional, Sturgill, Jamie, additional, Mayer, Kirby, additional, Montgomery-Yates, Ashley, additional, de Wit, Marjolein, additional, Mason, Jessica, additional, Goodwin, Andrew, additional, Grady, Abigail, additional, Burch, Patterson, additional, Enfield, Kyle B., additional, Sturek, Jeffrey M., additional, Marshall, Mary, additional, Bledsoe, Joseph R., additional, Brown, Samuel M., additional, Grissom, Colin K., additional, Armbruster, Brent, additional, Harris, Estelle, additional, Eppensteiner, John, additional, Hall, Bria Johnston, additional, Hall, Grace L., additional, McGowan, Lauren, additional, Bouffler, Andrew, additional, Walker, Erica, additional, Francis, Samuel, additional, Porter, Tedra, additional, deBoisblanc, Bennett P., additional, Lammi, Matthew R., additional, Janz, David R., additional, Lauto, Paula, additional, Romaine, Connie, additional, Sandi, Marie, additional, Rice, Todd W., additional, Self, Wesley H., additional, Ringwood, Nancy, additional, Nagrebetsky, Alexander, additional, Fitzgerald, Laura, additional, Brower, Roy G., additional, Reineck, Lora A., additional, Aggarwal, Neil R., additional, and Bienstock, Karen, additional

Published
2022
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