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Your search keyword '"Holder, Thomas M."' showing total 266 results
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266 results on '"Holder, Thomas M."'

1. Isolation of prion with BSE properties from farmed goat

Author

Spiropoulos, John, Lockey, Richard, Sallis, Rosemary E., Terry, Linda A., Thorne, Leigh, Holder, Thomas M., Beck, Katy E., and Simmons, Marion M.

Subjects
Prions -- Health aspects, Goats -- Health aspects, Public health -- Health aspects, Bovine spongiform encephalopathy -- Health aspects, Disease susceptibility -- Health aspects, Creutzfeldt-Jakob disease -- Health aspects, Health
Abstract

Transmissible spongiform encephalopathies (TSEs) are fatal diseases characterized by neurodegenerative changes in the central nervous system that include vacuolation, gliosis, and accumulation of an abnormal isoform ([PrP.sup.Sc]) of a naturally [...]

Published
2011
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2. Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile

Author

Beck, Katy E., Sallis, Rosemary E., Lockey, Richard, Vickery, Christopher M., Béringue, Vincent, Laude, Hubert, Holder, Thomas M., Thorne, Leigh, Terry, Linda A., Tout, Anna C., Jayasena, Dhanushka, Griffiths, Peter C., Cawthraw, Saira, Ellis, Richard, Balkema-Buschmann, Anne, Groschup, Martin H., Simmons, Marion M., and Spiropoulos, John

Published
2012
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6. Assessing the Susceptibility of Transgenic Mice Overexpressing Deer Prion Protein to Bovine Spongiform Encephalopathy

Author

Vickery, Christopher M., primary, Lockey, Richard, additional, Holder, Thomas M., additional, Thorne, Leigh, additional, Beck, Katy E., additional, Wilson, Christina, additional, Denyer, Margaret, additional, Sheehan, John, additional, Marsh, Sarah, additional, Webb, Paul R., additional, Dexter, Ian, additional, Norman, Angela, additional, Popescu, Emma, additional, Schneider, Amanda, additional, Holden, Paul, additional, Griffiths, Peter C., additional, Plater, Jane M., additional, Dagleish, Mark P., additional, Martin, Stuart, additional, Telling, Glenn C., additional, Simmons, Marion M., additional, and Spiropoulos, John, additional

Published
2014
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7. Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile

Author

Beck, Katy E., primary, Sallis, Rosemary E., additional, Lockey, Richard, additional, Vickery, Christopher M., additional, Béringue, Vincent, additional, Laude, Hubert, additional, Holder, Thomas M., additional, Thorne, Leigh, additional, Terry, Linda A., additional, Tout, Anna C., additional, Jayasena, Dhanushka, additional, Griffiths, Peter C., additional, Cawthraw, Saira, additional, Ellis, Richard, additional, Balkema‐Buschmann, Anne, additional, Groschup, Martin H., additional, Simmons, Marion M., additional, and Spiropoulos, John, additional

Published
2011
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17. Scrotal Ecchymosis.

Author

AMOURY, RAYMOND A., BARTH, GARY W., HALL, ROBERT T., RHODES, PHILIP G., HOLDER, THOMAS M., and ASHCRAFT, KEITH W.

Published
1982

19. Isolated, unruptured sinus of Valsalva aneurysm

Author

Mayer, John H., Holder, Thomas M., and Canent, Ramon V.

Abstract

Resection of an isolated, unruptured sinus of Valsalva aneurysm is described. Detection was serendipitous in a patient with previous surgical resection and grafting of significant aortic coarctation. The philosophy and importance of proceeding with elective resection in these progressive lesions is emphasized.

Published
1975
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20. Esophageal Atresia and Tracheoesophageal Fistula Malformations

Author

Ashcraft, Keith W. and Holder, Thomas M.

Abstract

The actual incidence of esophageal atresia and tracheoesophageal fistula abnormalities is difficult to assess. It is probably near 1 in 3000 births. This makes it one of the most frequent anomalies which, if not treated, will be uniformly fatal in the neonatal period.

Published
1976
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21. Abdominal Ultrasonography in Pediatrics

Author

Stuber, Jack L., Leonidas, John C., and Holder, Thomas M.

Abstract

• Ultrasonography has become an accepted diagnostic procedure, particularly in cardiology and obstetrics. It is also quite valuable in the evaluation of abdominal and retroperitoneal masses, with the unique ability to distinguish between cysts and solid tumors. The noninvasive and nonradiation-emitting features of ultrasound make it especially attractive for pediatric patients.(Am J Dis Child 129:1096-1101)

Published
1975
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22. Treatment of gastroesophageal reflux in children by Thal fundoplication

Author

Ashcraft, Keith W., Holder, Thomas M., and Amoury, Raymond A.

Abstract

The anterior fundoplication described by Thal has been used in treating gastroesophageal reflux surgically in 362 children at The Children's Mercy Hospital and at St. Luke's Hospital in Kansas City, Missouri, because medical therapy had failed or was inappropriate. Long-term results have been evaluated in regard to relief of reflux and relief of symptoms attributed to reflux. Of the 335 patients followed from 1 to 8 years, 90% had a satisfactory initial result. Five percent required reoperation for a recurrence of reflux due to failure of the fundoplication or development of a hiatus hernia. All recurrences developed within 5 months of the initial operation. Fifteen of 335 patients (4.5%) had persistent symptoms despite correction of the gastroesophageal reflux; in these patients, attributing the symptoms to reflux was incorrect. There were no deaths in this series of patients as a result of operation. The success rate of the Thal fundoplication in children compares favorably with that of the Nissen fundoplication.

Published
1981
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23. Developments in the Care of Patients with Esophageal Atresia and Tracheoesophageal Fistula

Author

Holder, Thomas M. and Ashcraft, Keith W.

Abstract

Both the mortality and morbidity associated with esophageal atresia and tracheoesophageal fistula have improved over the years. The treatment of patients with long-gap esophageal atresia by circular myotomy to the upper pouch with or without preoperative stretching has improved the care of patients with this problem.

Published
1981
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24. Care of infants with esophageal atresia, tracheoesophageal fistula, and associated anomalies

Author

Holder, Thomas M., Ashcraft, Keith W., Sharp, Ronald J., and Amoury, Raymond A.

Abstract

One hundred consecutive patients with esophageal atresia or tracheoesophageal fistula, or both, were treated at The Children’s Mercy Hospital during the past 14 years. Each patient was evaluated and a plan for therapy was formulated depending on the type and urgency of concomitant disease. Healthy patients were treated by primary repair. Those with respiratory disease were treated before repair by gastrostomy, upper pouch suction, and antibiotics. In the small premature infant and the patient with major associated anomalies, repair of the esophageal atresia and tracheoesophageal fistula was postponed by gastrostomy, upper pouch suction, and parenteral nutrition while the concomitant disease was treated. Fifteen patients with life-threatening associated anomalies required operation before esophageal repair and 13 of them survived. During the initial hospitalization two deaths related to esophageal atresia occurred, whereas three prerepair and two late (2½ and 3 months) postrepair deaths related to associated anomalies occurred. Thus, 93 of the 100 patients left the hospital alive. The increased survival is due not only to improved care of esophageal atresia and tracheoesophageal fistula, but also to a more aggressive approach to the treatment of the serious associated anomalies.

Published
1987
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25. Transannular GORE-TEX Patch with Pericardial Unicusp for Total Correction of Tetralogy of Fallot

Author

Canent, Ramon V., Anthony, Pam J., Holder, Thomas M., and Ashcraft, Keith W.

Subjects
Statistical Analysis, cardiovascular system, cardiovascular diseases
Abstract

When corrective surgery for tetralogy of Fallot was accomplished through the use of a transannular GORE-TEX patch with a pericardial unicusp, the right-ventricular end-diastolic volumes of all patients studied within a year of the surgery were within the normal ranges because of decreased pulmonary valve regurgitation. The right-ventricular ejection fraction was also only slightly depressed, indicating preservation of right-ventricular function. All patients were noted to maintain normal stroke volumes and normal systolic indices. In contrast, the patients who had transannular patches placed without unicusps showed significantly elevated right-ventricular end-diastolic volumes and lower right-ventricular ejection fractions. These resulted from markedly dilated right-ventricular outflow regions in conjunction with enlarged right-ventricular chambers, which manifested as large dyskinetic areas in the anterior right-ventricular walls.

Published
1987

26. Neonatal Intussusception Associated with Neonatal Small Left Colon Syndrome.

Author

Hall, Sue L., Murphy, J. Patrick, Holder, Thomas M., and Segal, Arlene E.

Subjects
BOWEL obstructions, GENETIC disorder diagnosis, CYSTIC fibrosis, HIRSCHSPRUNG'S disease, GENETIC disorders, CLINICAL medicine
Abstract

A newborn infant with intestinal obstruction resulting from intussusception associated with neonatal small left colon syndrome is described. Differences between neonatal and infantile intussusception are detailed. Chronic loose intussusception in utero is proposed as one cause of the neonatal small left colon syndrome. Consideration should be given to doing a rectal biopsy and a sweat chloride test to differentiate neonatal small left colon syndrome from Hirschsprung's disease and cystic fibrosis, respectively, when the clinical diagnosis is not readily apparent. [ABSTRACT FROM AUTHOR]

Published
1987
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