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Your search keyword '"Hernaez, Diana Canals"' showing total 9 results
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9 results on '"Hernaez, Diana Canals"'

2. A tumor-restricted glycoform of podocalyxin is a highly selective marker of immunologically cold high-grade serous ovarian carcinoma

Author

Brassard, Julyanne, primary, Hughes, Michael R., additional, Dean, Pamela, additional, Hernaez, Diana Canals, additional, Thornton, Shelby, additional, Banville, Allyson C., additional, Smazynski, Julian, additional, Warren, Mary, additional, Zhang, Kevin, additional, Milne, Katy, additional, Gilks, C. Blake, additional, Mes-Masson, Anne-Marie, additional, Huntsman, David G., additional, Nelson, Brad H., additional, Roskelley, Calvin D., additional, and McNagny, Kelly M., additional

Published
2023
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5. A tumor-restricted glycoepitope of podocalyxin correlates with immune evasion in high-grade serous ovarian carcinoma.

Author

Brassard, Julyanne, primary, Hernaez, Diana Canals, additional, Hughes, Michael R, additional, Milne, Katy, additional, Dean, Pamela, additional, Warren, Mary, additional, Zhang, Kevin, additional, Banville, Allyson C, additional, Smazynski, Julian, additional, Bond, David, additional, Nelson, Brad H, additional, Roskelley, Calvin D, additional, and McNagny, Kelly M, additional

Published
2022
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7. Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

Author

Snyder, Kimberly A, primary, Hughes, Michael R, additional, Hedberg, Bradley, additional, Brandon, Jill, additional, Hernaez, Diana Canals, additional, Bergqvist, Peter, additional, Cruz, Frederic, additional, Po, Kelvin, additional, Graves, Marcia L, additional, Turvey, Michelle E, additional, Nielsen, Julie S, additional, Wilkins, John A, additional, McColl, Shaun R, additional, Babcook, John S, additional, Roskelley, Calvin D, additional, and McNagny, Kelly M, additional

Published
2015
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8. Declined presentation

Author

Hughes, Michael, primary, Lo, Bernard, additional, Antignano, Frann, additional, Nielsen, Julie, additional, Cait, Jessie, additional, Hernaez, Diana Canals, additional, Tan, Poh, additional, and McNagny, Kelly, additional

Published
2013
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9. IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection.

Author

Lo, Bernard C., Shin, Samuel B., Hernaez, Diana Canals, Refaeli, Ido, Yu, Hong B., Goebeler, Verena, Cait, Alissa, Mohn, William W., Vallance, Bruce A., and McNagny, Kelly M.

Subjects
*SALMONELLA diseases, *DISEASE remission, *INTEGRITY
Abstract

The cytokine IL-22 is rapidly induced at barrier surfaces where it regulates host-protective antimicrobial immunity and tissue repair but can also enhance disease severity in some chronic inflammatory settings. Using the chronic Salmonella gastroenteritis model, Ab-mediated neutralization of IL-22 impaired intestinal epithelial barrier integrity and, consequently, exaggerated expression of proinflammatory cytokines. As disease normally resolved, neutralization of IL-22 caused luminal narrowing of the cecum-a feature reminiscent of fibrotic strictures seen in Crohn disease patients. Corresponding to the exaggerated immunopathology caused by IL-22 suppression, Salmonella burdens in the gut were reduced. This enhanced inflammation and pathogen clearance was associated with alterations in gut microbiome composition, including the overgrowth of Bacteroides acidifaciens. Our findings thus indicate that IL-22 plays a protective role by limiting infection-induced gut immunopathology but can also lead to persistent pathogen colonization. [ABSTRACT FROM AUTHOR]

Published
2019
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