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253 results on '"Heidary, Mohsen"'

1. Trends in multidrug-resistant tuberculosis in Tehran, Iran: an analysis of published data

Author

Nasiri, Mohammad Javad, Heidary, Mohsen, Goudarzi, Hossein, and Tabarsi, Payam

Subjects
tuberculosis, MDR-TB, Tehran, Iran, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502
Abstract

Introduction: Multidrug-resistant tuberculosis (MDR-TB) is one of the major public health threats especially in developing countries. In Iran, the emergence and spread of MDR-TB are likely to pose a significant problem for the National Tubeculosis Control Program (NTP). In this study, to determine the trend of MDR-TB in Tehran, the results of published studies were analyzed.Methods: Several databases were searched, including Medline, Embase, Web of Science and Iranian databases. Studies which report the preva of MDR-TB by World Health Organization (WHO)-endorsed drug susceptibility testing (DST) methods were included in the study. Data were analyzed with SPSS 20 (SPSS, Chicago, Illinois, USA).Results: Analysis of the MDR-TB trend did not show any increase among new TB cases, but the trend of MDR-TB was significantly increased among previously treated cases. The prevalence of MDR-TB from 48.0% in 1996 reached 58.0% in 2004 (P

Published
2019
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12. The immunopathogenesis of Helicobacter pylori-induced gastric cancer: a narrative review.

Author

Shirani, Maryam, Shariati, Saeedeh, Bazdar, Monireh, Ghamnak, Faezeh Sojoudi, Moradi, Melika, Khozani, Reyhane Shams, Taki, Elahe, Arabsorkhi, Zahra, Heidary, Mohsen, and Eskandari, Dorsa Bahrami

Subjects
HELICOBACTER pylori, STOMACH cancer, HELICOBACTER pylori infections, HELICOBACTER, BLOOD groups, TOLL-like receptors
Abstract

Helicobacter pylori infection is a well-established risk factor for the development of gastric cancer (GC). Understanding the immunopathogenesis underlying this association is crucial for developing effective preventive and therapeutic strategies. This narrative review comprehensively explores the immunopathogenesis of H. pylori-induced GC by delving into several key aspects, emphasizing the pivotal roles played by H. pylori virulence factors, including cytotoxin-associated gene A (cagA) and vacuolating cytotoxin A (vacA), blood group antigen-binding adhesin (babA), and sialic acid binding adhesin (sabA). Moreover, the review focuses on the role of toll-like receptors (TLRs) and cytokines in the complex interplay between chronic infection and gastric carcinogenesis. Finally, the study examines the association between H. pylori evasion of the innate and adaptive immune response and development of GC. A comprehensive understanding of the immunopathogenesis of H. pylori-induced GC is essential for designing targeted interventions to prevent and manage this disease. Further research is warranted to elucidate the intricate immune responses involved and identify potential therapeutic targets to improve patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Evaluating the incidence of ampC-lactamase genes, biofilm formation, and antibiotic resistance among hypervirulent and classical Klebsiella pneumoniae strains

Author

Haddadi, Mohammad Hossein, primary, Khoshnood, Saeed, additional, Koupaei, Maryam, additional, Heidary, Mohsen, additional, Moradi, Melika, additional, Jamshidi, Ali, additional, Behrouj, Hamid, additional, Movahedpour, Ahmad, additional, Maleki, Mohammad Hassan, additional, and Ghanavati, Roya, additional

Published
2023
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25. Epidemiology of HBV-HCV Coinfection Among Iranian Patients: a Systematic Review and Meta-Analysis.

Author

Anvari, Hamed Z., Binabaj, Maryam M., Asadi, Arezoo, Abdi, Milad, Shakiba, Abolfazl, Heidary, Mohsen, and Sholeh, Mohammad

Subjects
IRANIANS, HEPATITIS C virus, HEPATITIS B virus, MIXED infections, SCIENCE databases
Abstract

Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causes of hepatitis, an important disease affecting millions of people worldwide. The present study aimed to estimate the prevalence of HBV-HCV coinfection in Iran and evaluate the demographic and behavioral factors associated with a heterogeneity of results. Methods: We used MEDLINE/PubMed, Web of Science, SCOPUS, Google Scholar, and 1 Persian database (Scientific Information Database) for a systematic search from January 1, 2005 to February 26, 2022. Data were analyzed based on the city, publication time, enrollment time, number of patients, gender, mean age, and HBV/HCV diagnosis method. The analysis was carried out using R (version 4.2.1) and the metafor package (version 3.8.1). Results: In total, 2,072 studies were found through databases: PubMed/Medline (n = 224), Scopus (n = 1,092), Web of Science (n = 394), Google Scholar (n = 272), and Scientific Information Database (n = 90). Overall, nine studies with 1,964 male and 1,909 female patients (age average = 38.1) were included in the analysis. The observed proportion ranged from 0.004 to 0.273. The estimated average proportion was μ = 0.040 (95% CI: 0.016 to 0.101). Therefore, the average outcome differed significantly from zero (z = -6.330, p < 0.001). Conclusions: HBV/HCV coinfection is a challenging and crucial medical condition because of its variable clinical manifestations, increased risk of cirrhosis and HCC, and unpredictable treatment response. There is a heterogeneous distribution pattern of HBV/HCV infection between Iran's provinces, indicating the necessity of continuous prevention and control measurements and the implementation of further epidemiologic studies for collecting reliable data on HBV/HCV prevalence in different parts of Iran. [ABSTRACT FROM AUTHOR]

Published
2023
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26. The prevalence of clarithromycin-resistant Helicobacter pylori isolates: a systematic review and meta-analysis

Author

Sholeh, Mohammad, primary, Khoshnood, Saeed, additional, Azimi, Taher, additional, Mohamadi, Jasem, additional, Kaviar, Vahab Hassan, additional, Hashemian, Marzieh, additional, Karamollahi, Somayeh, additional, Sadeghifard, Nourkhoda, additional, Heidarizadeh, Hedayat, additional, Heidary, Mohsen, additional, and Saki, Morteza, additional

Published
2023
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32. Molecular typing and antibiotic resistance patterns among clinical isolates of Acinetobacter baumannii recovered from burn patients in Tehran, Iran

Author

Maleki, Abbas, Kaviar, Vahab Hassan, Koupaei, Maryam, Haddadi, Mohammad Hossein, Kalani, Behrooz Sadeghi, Valadbeigi, Hassan, Karamolahi, Somayeh, Omidi, Nazanin, Hashemian, Marziyeh, Sadeghifard, Nourkhoda, Mohamadi, Jasem, Heidary, Mohsen, and Khoshnood, Saeed

Subjects
Microbiology (medical), Microbiology
Abstract

Acinetobacter baumannii (A. baumannii) is now considered a highly resistant pathogen to various types of antibiotics. Therefore, tracking the source of its prevalence and continuous control is crucial. This study aimed to determine antibiotic resistance and perform various molecular typing methods on clinical isolates of A. baumannii isolated from hospitalized burn patients in Shahid Motahari Burn Hospital, Tehran, Iran. Hospital isolates were confirmed by phenotypic and molecular methods. Then the sensitivity to different antibiotics was determined using the minimum inhibitory concentration (MIC) method. In order to perform molecular typing, three-locus dual assay multiplex polymerase chain reaction (PCR), multiple-locus variable-number tandem repeat analysis (MLVA), and multilocus sequence typing (MLST) methods were used. Among the 60 isolates collected, the frequencies of multidrug-resistant (MDR) and extensively drug-resistant (XDR) isolates were 90 and 10%, respectively. The most effective antibiotics were colistin with 100% and tigecycline with 83.33% sensitivity. Isolates were 100% resistant to piperacillin/tazobactam and cephalosporins, and 68.3% were resistant to carbapenem. The results of multiplex PCR showed five groups that international clone I (IC I) and IC II were the most common. The MLVA method identified 34 MLVA types (MTs), 5 clusters, and 25 singletons. Multilocus sequence typing results for tigecycline-resistant isolates showed seven different sequence types (STs). Increasing antibiotic resistance in A. baumannii isolates requires careful management to control and prevent the occurrence of the pre-antibiotic era. The results of this study confirm that the population structure of A. baumannii isolates has a high diversity. More extensive studies are needed in Iran to better understand the epidemiology of A. baumannii.

Published
2022
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33. Efficacy of drug regimen with and without oseltamivir in hospitalized patients with COVID-19: A retrospective study

Author

Shokri, Fazlollah, primary, Rezapoor, Saeed, additional, Najafi, Masoud, additional, Asadi, Mohsen, additional, alavije, Mohammad Karimi, additional, Abolhassani, Moussa, additional, Moieneddin, Mohammad Hossein, additional, Ashrafi, Amir Muhammad, additional, Gholipour, Narges, additional, Naderi, Parisa, additional, Charati, Jamshid Yazdani, additional, Alizadeh-Navaei, Reza, additional, Saeedi, Majid, additional, Heidary, Mohsen, additional, and Rostamnezhad, Mostafa, additional

Published
2022
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37. Natural Compounds: A Hopeful Promise as an Antibiofilm Agent Against Candida Species

Author

Shariati, Aref, Didehdar, Mojtaba, Razavi, Shabnam, Heidary, Mohsen, Soroush, Fatemeh, and Chegini, Zahra

Subjects
Pharmacology, Pharmacology (medical)
Abstract

The biofilm communities of Candida are resistant to various antifungal treatments. The ability of Candida to form biofilms on abiotic and biotic surfaces is considered one of the most important virulence factors of these fungi. Extracellular DNA and exopolysaccharides can lower the antifungal penetration to the deeper layers of the biofilms, which is a serious concern supported by the emergence of azole-resistant isolates and Candida strains with decreased antifungal susceptibility. Since the biofilms’ resistance to common antifungal drugs has become more widespread in recent years, more investigations should be performed to develop novel, inexpensive, non-toxic, and effective treatment approaches for controlling biofilm-associated infections. Scientists have used various natural compounds for inhibiting and degrading Candida biofilms. Curcumin, cinnamaldehyde, eugenol, carvacrol, thymol, terpinen-4-ol, linalool, geraniol, cineole, saponin, camphor, borneol, camphene, carnosol, citronellol, coumarin, epigallocatechin gallate, eucalyptol, limonene, menthol, piperine, saponin, α-terpineol, β–pinene, and citral are the major natural compounds that have been used widely for the inhibition and destruction of Candida biofilms. These compounds suppress not only fungal adhesion and biofilm formation but also destroy mature biofilm communities of Candida. Additionally, these natural compounds interact with various cellular processes of Candida, such as ABC-transported mediated drug transport, cell cycle progression, mitochondrial activity, and ergosterol, chitin, and glucan biosynthesis. The use of various drug delivery platforms can enhance the antibiofilm efficacy of natural compounds. Therefore, these drug delivery platforms should be considered as potential candidates for coating catheters and other medical material surfaces. A future goal will be to develop natural compounds as antibiofilm agents that can be used to treat infections by multi-drug-resistant Candida biofilms. Since exact interactions of natural compounds and biofilm structures have not been elucidated, further in vitro toxicology and animal experiments are required. In this article, we have discussed various aspects of natural compound usage for inhibition and destruction of Candida biofilms, along with the methods and procedures that have been used for improving the efficacy of these compounds.

Published
2022
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38. Global Estimate of Clarithromycin Resistance in Clinical Isolates of Helicobacter pylori: a Systematic Review and Meta-Analysis.

Author

Khoshnood, Saeed, Pakzad, Reza, Kaviar, Vahab Hassan, Hashemian, Marzieh, Karamollahi, Somayeh, Sadeghifard, Nourkhoda, Heidarizadeh, Hedayat, Moradi, Melika, Maleki, Abbas, Heidary, Mohsen, and Abdi, Milad

Subjects
HELICOBACTER pylori, CLARITHROMYCIN, DRUG resistance in bacteria, CLINICAL trials
Abstract

Background: A high resistance rate to clarithromycin usually leads to failure to eradicate Helicobacter pylori. The aim of the present study was to review recent data on H. pylori resistance towards clarithromycin in clinical studies worldwide. Methods: PubMed/Medline, Web of Science, and Embase were used for a systematic review from 1 January 2011 to 13 April 2021 to retrieve the clinical trial studies. Data were analyzed according to publication year, age, geographic area, and minimum inhibitory concentration (MIC). Statistical analysis was done by STATA version 14.0 (College Station, Texas). Results: From a total of 4,304 articles, 89 articles related to clinical studies were selected for analysis. The overall H. pylori clarithromycin resistance rate was 34.95%. Based on continents, the highest and lowest pooled estimate of the bacterial resistance rates were observed in Asia (35.97%) and North America (7.02%), respectively. The highest and the lowest pooled estimate of H. pylori resistance rate to clarithromycin based on country were obtained in Australia (93.4%) and USA (7%), respectively. Conclusions: H. pylori resistance to clarithromycin in most parts of the world is more than 15%, so it is recommended that each country, after estimating the rate of resistance to clarithromycin, determine the treatment/eradication pattern for H. pylori infection. [ABSTRACT FROM AUTHOR]

Published
2023
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